Harvard Catalyst Profiles

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Craig Palmer Hersh, M.D.

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Harvard College, Cambridge, MAAB06/1993Biochemical Sciences
University of Pennsylvania, Philadelphia, PAMD06/1997Medicine
Harvard School of Public Health, Boston, MAMPH06/2004Quantitative Methods
Hospital of the University of Pennsylvania, Philadelphia, PA06/2000Internal Medicine Residency
Harvard Medical School, Boston, MA06/2004Pulmonary and Critical Care Fellowship
Brigham and Women's Hospital, Boston, MA06/2005Respiratory Epidemiology Fellowship

I am a physician-scientist trained in Pulmonary and Critical Care Medicine and Genetic Epidemiology. I am an Associate Physician in the Channing Division of Network Medicine at Brigham and Women's Hospital (BWH) and an Associate Professor at Harvard Medical School. My research uses the tools of clinical epidemiology, genetics, and genomics to understand chronic obstructive pulmonary disease (COPD) phenotypes and treatment responses, moving towards personalized medicine for this heterogeneous disease. I am the Principal Investigator of several ancillary studies to the COPDGene Study, funded by the National Heart, Lung and Blood Institute (NHLBI), and I am the co-director of the COPDGene Clinical Center at BWH. My clinical practice focuses on COPD and emphysema, including the overlap between COPD and asthma, as well as Alpha-1 Antitrypsin Deficiency, a genetic form of COPD.

Available: 04/05/22, Expires: 06/01/23

My research uses the tools of clinical epidemiology and genetics to understand chronic obstructive pulmonary disease (COPD) phenotypes and treatment responses, moving towards personalized medicine for this heterogeneous disease. We are particularly interested in clinically-relevant COPD subtypes, such as patients with frequent exacerbations, airway disease, and the overlapping diagnoses of asthma and COPD. Most of the research is centered within the COPDGene Study, a multi-center longitudinal study of smokers with and without COPD. We are able to leverage the wealth of clinical information, chest CT scans, genetic and biomarker data within COPDGene to examine multiple research questions.

Available: 12/01/22, Expires: 12/01/24

My lab studies the genetic epidemiology of chronic obstructive pulmonary disease (COPD). Most of my research is within the COPDGene Study, a longitudinal study of over 10,000 current and former smokers followed for more than 10 years. In addition, we utilize other large studies, such as the Lung Tissue Research Consortium. My group's approach to COPD genetic epidemiology is to start with a clinical question, then try to understand the epidemiology, such as disease phenotypes and subtypes. Then we incorporate genomics and biomarkers. There are multiple potential projects analyzing these datasets, which can last a few months to a year or longer. Previous short-term projects included associating vitamin D deficiency with COPD symptoms and chest CT scan findings. A previous medical student completed a cluster analysis of COPD subjects using blood protein biomarkers. There are opportunities for other epidemiology projects, studying COPD exacerbations for example, and analysis of RNA-sequencing and biomarker datasets. The student would be responsible for data analysis, with supervision from the PI and other lab members. Prior experience with statistical programming, particularly using R, is beneficial. The work can be done remotely.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL157879 (BENOS, PANAGIOTIS V) Jul 1, 2021 - Jun 30, 2025
    Role: Co-Principal Investigator
  2. R01HL130512 (HERSH, CRAIG P) Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
  3. R01HL125583 (HERSH, CRAIG P) Sep 1, 2015 - Dec 31, 2020
    Role: Principal Investigator
  4. R01NR013377 (HERSH, CRAIG P) Sep 27, 2011 - Jan 31, 2016
    Role: Principal Investigator
  5. R01HL094635 (HERSH, CRAIG P) Sep 4, 2009 - Jan 31, 2017
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wilson AC, Bon JM, Mason S, Diaz AA, Lutz SM, Estepar RSJ, Kinney GL, Hokanson JE, Rennard SI, Casaburi R, Bhatt SP, Irvin MR, Hersh CP, Dransfield MT, Washko GR, Regan EA, McDonald ML. Increased chest CT derived bone and muscle measures capture markers of improved morbidity and mortality in COPD. Respir Res. 2022 Nov 15; 23(1):311. PMID: 36376854; PMCID: PMC9664607.
    Citations:    Fields:    Translation:Humans
  2. Serban KA, Pratte KA, Strange C, Sandhaus RA, Turner AM, Beiko T, Spittle DA, Maier L, Hamzeh N, Silverman EK, Hobbs BD, Hersh CP, DeMeo DL, Cho MH, Bowler RP. Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease. EBioMedicine. 2022 Oct; 84:104262. PMID: 36155958; PMCID: PMC9507992.
    Citations:    Fields:    Translation:Humans
  3. Zhang W, Wendt C, Bowler R, Hersh CP, Safo SE. Robust integrative biclustering for multi-view data. Stat Methods Med Res. 2022 11; 31(11):2201-2216. PMID: 36113157.
    Citations:    Fields:    
  4. Balasubramanian A, Putcha N, MacIntyre NR, Jensen RL, Kinney G, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Barr RG, Regan E, Make BJ, Hansel NN, Wise RA, McCormack MC. Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2022 Aug 15. PMID: 35969416.
    Citations:    Fields:    
  5. Saferali A, Qiao D, Kim W, Raraigh K, Levy H, Diaz AA, Cutting GR, Cho MH, Hersh CP. CFTR variants are associated with chronic bronchitis in smokers. Eur Respir J. 2022 08; 60(2). PMID: 34996830.
    Citations:    Fields:    
  6. Gregory A, Xu Z, Pratte K, Lee S, Liu C, Chase R, Yun J, Saferali A, Hersh CP, Bowler R, Silverman E, Castaldi PJ, Boueiz A. Clustering-based COPD subtypes have distinct longitudinal outcomes and multi-omics biomarkers. BMJ Open Respir Res. 2022 08; 9(1). PMID: 35999035; PMCID: PMC9403129.
    Citations: 1     Translation:HumansCTClinical Trials
  7. Saferali A, Hersh CP. Genetic Determinants in Airways Obstructive Diseases: The Case of Asthma Chronic Obstructive Pulmonary Disease Overlap. Immunol Allergy Clin North Am. 2022 08; 42(3):559-573. PMID: 35965045.
    Citations:    Fields:    Translation:Humans
  8. Gereige JD, Xu H, Ortega VE, Cho MH, Liu M, Sakornsakolpat P, Silverman EK, Beaty TH, Miller BE, Bakke P, Gulsvik A, Hersh CP, Morrow JD, Ampleford EJ, Hawkins GA, Bleecker ER, Meyers DA, Peters SP, Celedón JC, Tantisira K, Li J, Dupuis J, O'Connor GT. A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts. ERJ Open Res. 2022 Apr; 8(2). PMID: 35769418; PMCID: PMC9234425.
  9. Moll M, Hobbs BD, Menon A, Ghosh AJ, Putman RK, Hino T, Hata A, Silverman EK, Quackenbush J, Castaldi PJ, Hersh CP, McGeachie MJ, Sin DD, Tal-Singer R, Nishino M, Hatabu H, Hunninghake GM, Cho MH. Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies. Respir Res. 2022 Jun 17; 23(1):157. PMID: 35715807; PMCID: PMC9204872.
    Citations:    Fields:    Translation:HumansCells
  10. Palzer EF, Wendt CH, Bowler RP, Hersh CP, Safo SE, Lock EF. sJIVE: Supervised Joint and Individual Variation Explained. Comput Stat Data Anal. 2022 Nov; 175. PMID: 36119152; PMCID: PMC9481062.
  11. Yun JH, Lee S, Srinivasa P, Morrow J, Chase R, Saferali A, Xu Z, Cho M, Castaldi P, Hersh CP. An interferon-inducible signature of airway disease from blood gene expression profiling. Eur Respir J. 2022 05; 59(5). PMID: 34649980; PMCID: PMC9245457.
    Citations:    Fields:    Translation:Humans
  12. Ghosh AJ, Hobbs BD, Yun JH, Saferali A, Moll M, Xu Z, Chase RP, Morrow J, Ziniti J, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, McGoldrick D, Cho MH, DeMeo DL, Silverman EK, Castaldi PJ, Hersh CP. Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Respir Res. 2022 Apr 21; 23(1):97. PMID: 35449067; PMCID: PMC9026726.
    Citations:    Fields:    Translation:HumansCells
  13. Tiwari A, Hobbs BD, Li J, Kho AT, Amr S, Celedón JC, Weiss ST, Hersh CP, Tantisira KG, McGeachie MJ. Blood miRNAs Are Linked to Frequent Asthma Exacerbations in Childhood Asthma and Adult COPD. Noncoding RNA. 2022 Apr 03; 8(2). PMID: 35447890; PMCID: PMC9030787.
  14. Ghosh AJ, Hobbs BD, Moll M, Saferali A, Boueiz A, Yun JH, Sciurba F, Barwick L, Limper AH, Flaherty K, Criner G, Brown KK, Wise R, Martinez FJ, Lomas D, Castaldi PJ, Carey VJ, DeMeo DL, Cho MH, Silverman EK, Hersh CP. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323. PMID: 34762809; PMCID: PMC8886988.
    Citations: 3     Fields:    Translation:Humans
  15. John C, Guyatt AL, Shrine N, Packer R, Olafsdottir TA, Liu J, Hayden LP, Chu SH, Koskela JT, Luan J, Li X, Terzikhan N, Xu H, Bartz TM, Petersen H, Leng S, Belinsky SA, Cepelis A, Hernández Cordero AI, Obeidat M, Thorleifsson G, Meyers DA, Bleecker ER, Sakoda LC, Iribarren C, Tesfaigzi Y, Gharib SA, Dupuis J, Brusselle G, Lahousse L, Ortega VE, Jonsdottir I, Sin DD, Bossé Y, van den Berge M, Nickle D, Quint JK, Sayers I, Hall IP, Langenberg C, Ripatti S, Laitinen T, Wu AC, Lasky-Su J, Bakke P, Gulsvik A, Hersh CP, Hayward C, Langhammer A, Brumpton B, Stefansson K, Cho MH, Wain LV, Tobin MD. Genetic Associations and Architecture of Asthma-COPD Overlap. Chest. 2022 05; 161(5):1155-1166. PMID: 35104449; PMCID: PMC9131047.
    Citations: 1     Fields:    Translation:Humans
  16. Moll M, Boueiz A, Ghosh AJ, Saferali A, Lee S, Xu Z, Yun JH, Hobbs BD, Hersh CP, Sin DD, Tal-Singer R, Silverman EK, Cho MH, Castaldi PJ. Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 01 15; 205(2):161-170. PMID: 34739356; PMCID: PMC8787248.
    Citations: 2     Fields:    Translation:Humans
  17. Lackey L, Coria A, Ghosh AJ, Grayeski P, Hatfield A, Shankar V, Platig J, Xu Z, Ramos SBV, Silverman EK, Ortega VE, Cho MH, Hersh CP, Hobbs BD, Castaldi P, Laederach A. Alternative poly-adenylation modulates a1-antitrypsin expression in chronic obstructive pulmonary disease. PLoS Genet. 2021 11; 17(11):e1009912. PMID: 34784346.
    Citations:    Fields:    Translation:HumansCells
  18. Xu Z, Platig J, Lee S, Boueiz A, Chase R, Jain D, Gregory A, Suryadevara R, Berman S, Bowler R, Hersh CP, Laederach A, Castaldi PJ. Cigarette smoking-associated isoform switching and 3' UTR lengthening via alternative polyadenylation. Genomics. 2021 11; 113(6):4184-4195. PMID: 34763026; PMCID: PMC8722433.
    Citations:    Fields:    Translation:Cells
  19. Zhuang Y, Hobbs BD, Hersh CP, Kechris K. Identifying miRNA-mRNA Networks Associated With COPD Phenotypes. Front Genet. 2021; 12:748356. PMID: 34777474; PMCID: PMC8581181.
    Citations: 1     
  20. Wang Z, Masoomi A, Xu Z, Boueiz A, Lee S, Zhao T, Bowler R, Cho M, Silverman EK, Hersh C, Dy J, Castaldi PJ. Improved prediction of smoking status via isoform-aware RNA-seq deep learning models. PLoS Comput Biol. 2021 10; 17(10):e1009433. PMID: 34634029; PMCID: PMC8530282.
    Citations:    Fields:    Translation:Humans
  21. Morrow JD, Castaldi PJ, Chase RP, Yun JH, Lee S, Liu YY, Hersh CP. Peripheral blood microbial signatures in current and former smokers. Sci Rep. 2021 10 06; 11(1):19875. PMID: 34615932; PMCID: PMC8494912.
    Citations: 1     Fields:    Translation:Humans
  22. Daya M, Cox C, Acevedo N, Boorgula MP, Campbell M, Chavan S, Cho MH, David GL, Kachroo P, Lasky-Su J, Li X, McHugh CP, Qiao D, Rafaels N, Beck LA, Bleecker ER, Caraballo L, Cupples AL, Figueiredo CA, Gallo RL, Hanifin J, Hansel NN, Hata TR, Hersh CP, Knight-Madden J, Leung DYM, Guttman-Yassky E, Meyers DA, O'Connor G, Ober C, Ong PY, Ortega VE, Paller AS, Putcha N, Reed RM, Schneider LC, Silverman EK, Slifka MK, Spergel JM, Vasan RS, Viaud-Martinez KA, Watson H, Weiss ST, Ruczinski I, Beaty TH, Mathias RA, Barnes KC. Multiethnic genome-wide and HLA association study of total serum IgE level. J Allergy Clin Immunol. 2021 12; 148(6):1589-1595. PMID: 34536413; PMCID: PMC8665111.
    Citations: 1     Fields:    Translation:Humans
  23. Lakshman Kumar P, Wilson AC, Rocco A, Cho MH, Wan E, Hobbs BD, Washko GR, Ortega VE, Christenson SA, Li X, Wells JM, Bhatt SP, DeMeo DL, Lutz SM, Rossiter H, Casaburi R, Rennard SI, Lomas DA, Labaki WW, Tal-Singer R, Bowler RP, Hersh CP, Tiwari HK, Dransfield M, Thalacker-Mercer A, Meyers DA, Silverman EK, McDonald MN. Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease. J Cachexia Sarcopenia Muscle. 2021 12; 12(6):1803-1817. PMID: 34523824; PMCID: PMC8718068.
    Citations: 2     Fields:    Translation:Humans
  24. Polverino F, Wu TD, Rojas-Quintero J, Wang X, Mayo J, Tomchaney M, Tram J, Packard S, Zhang D, Cleveland KH, Cordoba-Lanus E, Owen CA, Fawzy A, Kinney GL, Hersh CP, Hansel NN, Doubleday K, Sauler M, Tesfaigzi Y, Ledford JG, Casanova C, Zmijewski J, Konhilas J, Langlais PR, Schnellmann R, Rahman I, McCormack M, Celli B. Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment. Am J Respir Crit Care Med. 2021 09 15; 204(6):651-666. PMID: 34033525; PMCID: PMC8521702.
    Citations: 10     Fields:    Translation:HumansAnimals
  25. Yun JH, Lee C, Liu T, Liu S, Kim EY, Xu S, Curtis JL, Pinello L, Bowler RP, Silverman EK, Hersh CP, Zhou X. Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice. JCI Insight. 2021 09 08; 6(17). PMID: 34375314; PMCID: PMC8492352.
    Citations: 1     Fields:    Translation:AnimalsCells
  26. Gillenwater LA, Helmi S, Stene E, Pratte KA, Zhuang Y, Schuyler RP, Lange L, Castaldi PJ, Hersh CP, Banaei-Kashani F, Bowler RP, Kechris KJ. Multi-omics subtyping pipeline for chronic obstructive pulmonary disease. PLoS One. 2021; 16(8):e0255337. PMID: 34432807; PMCID: PMC8386883.
    Citations:    Fields:    Translation:Humans
  27. Balasubramanian A, Henderson RJ, Putcha N, Fawzy A, Raju S, Hansel NN, MacIntyre NR, Jensen RL, Kinney GL, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Make BJ, McCormack MC, Wise RA. Haemoglobin as a biomarker for clinical outcomes in chronic obstructive pulmonary disease. ERJ Open Res. 2021 Jul; 7(3). PMID: 34322549.
    Citations: 1     
  28. Ghosh AJ, Saferali A, Lee S, Chase R, Moll M, Morrow J, Yun J, Castaldi PJ, Hersh CP. Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains. Thorax. 2022 02; 77(2):115-122. PMID: 34168019; PMCID: PMC8711128.
    Citations: 3     Fields:    Translation:Humans
  29. Levin JC, Sheils CA, Gaffin JM, Hersh CP, Rhein LM, Hayden LP. Lung function trajectories in children with post-prematurity respiratory disease: identifying risk factors for abnormal growth. Respir Res. 2021 May 10; 22(1):143. PMID: 33971884.
    Citations: 4     Fields:    Translation:Humans
  30. LaBelle J, Bowser M, Brown A, Farnam L, Kho A, Li J, McGeachie M, Chase R, Piehl S, Allen K, Hobbs BD, Weiss ST, Hersh C, Tantisira K, Amr SS. Commercially Available Blocking Oligonucleotides Effectively Suppress Unwanted Hemolysis-Related miRNAs in a Large Whole-Blood RNA Cohort. J Mol Diagn. 2021 06; 23(6):671-682. PMID: 33872788; PMCID: PMC8207476.
    Citations: 4     Fields:    Translation:Humans
  31. R Arnold N, S Wan E, Hersh CP, Schwartz A, Kinney G, Young K, Hokanson J, Regan EA, P Comellas A, Fortis S. Inhaled Medication Use in Smokers With Normal Spirometry. Respir Care. 2021 Apr; 66(4):652-660. PMID: 33563793.
    Citations:    Fields:    Translation:Humans
  32. Saferali A, Yun JH, Lee S, Chase RP, Bowler RP, Castaldi PJ, Hersh CP. Transcriptomic Signature of Asthma-Chronic Obstructive Pulmonary Disease Overlap in Whole Blood. Am J Respir Cell Mol Biol. 2021 02; 64(2):268-271. PMID: 33522883; PMCID: PMC7874396.
    Citations: 1     Fields:    Translation:HumansCells
  33. Saferali A, Xu Z, Sheynkman GM, Hersh CP, Cho MH, Silverman EK, Laederach A, Vollmers C, Castaldi PJ. Characterization of a COPD-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing. medRxiv. 2020 Nov 03. PMID: 33173926.
  34. Moll M, Lutz SM, Ghosh AJ, Sakornsakolpat P, Hersh CP, Beaty TH, Dudbridge F, Tobin MD, Mittleman MA, Silverman EK, Hobbs BD, Cho MH. Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies. BMJ Open Respir Res. 2020 11; 7(1). PMID: 33239407; PMCID: PMC7689586.
    Citations: 3     Translation:Humans
  35. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 11 01; 202(9):1225-1236. PMID: 32551799; PMCID: PMC7605184.
    Citations: 7     Fields:    Translation:HumansCells
  36. Koo HK, Morrow J, Kachroo P, Tantisira K, Weiss ST, Hersh CP, Silverman EK, DeMeo DL. Sex-specific associations with DNA methylation in lung tissue demonstrate smoking interactions. Epigenetics. 2021 06; 16(6):692-703. PMID: 32962511; PMCID: PMC8143227.
    Citations: 4     Fields:    Translation:HumansCells
  37. Divo MJ, Marin Oto M, Casanova Macario C, Cabrera Lopez C, de-Torres JP, Marin Trigo JM, Hersh CP, Ezponda Casajús A, Maguire C, Pinto-Plata VM, Polverino F, Ross JC, DeMeo D, Bastarrika G, Silverman EK, Celli BR. Somatotypes trajectories during adulthood and their association with COPD phenotypes. ERJ Open Res. 2020 Jul; 6(3). PMID: 32963991; PMCID: PMC7487345.
    Citations: 1     
  38. Franciosi AN, Hobbs BD, McElvaney OJ, Molloy K, Hersh C, Clarke L, Gunaratnam C, Silverman EK, Carroll TP, McElvaney NG. Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency. Am J Respir Crit Care Med. 2020 07 01; 202(1):73-82. PMID: 32197047; PMCID: PMC7530947.
    Citations: 6     Fields:    Translation:Humans
  39. Putcha N, Fawzy A, Matsui EC, Liu MC, Bowler RP, Woodruff PG, O'Neal WK, Comellas AP, Han MK, Dransfield MT, Wells JM, Lugogo N, Gao L, Talbot CC, Hoffman EA, Cooper CB, Paulin LM, Kanner RE, Criner G, Ortega VE, Barr RG, Krishnan JA, Martinez FJ, Drummond MB, Wise RA, Diette GB, Hersh CP, Hansel NN. Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-analysis of SPIROMICS and COPDGene. Chest. 2020 12; 158(6):2333-2345. PMID: 32450244; PMCID: PMC7768932.
    Citations: 6     Fields:    Translation:Humans
  40. Ghosh AJ, Moll M, Hayden LP, Bon J, Regan E, Hersh CP. Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study. BMC Pulm Med. 2020 May 04; 20(1):123. PMID: 32366316.
    Citations: 8     Fields:    Translation:Humans
  41. Wilson AC, Kumar PL, Lee S, Parker MM, Arora I, Morrow JD, Wouters EFM, Casaburi R, Rennard SI, Lomas DA, Agusti A, Tal-Singer R, Dransfield MT, Wells JM, Bhatt SP, Washko G, Thannickal VJ, Tiwari HK, Hersh CP, Castaldi PJ, Silverman EK, McDonald MN. Heme metabolism genes Downregulated in COPD Cachexia. Respir Res. 2020 May 01; 21(1):100. PMID: 32354332.
    Citations:    Fields:    Translation:HumansCells
  42. Morrow JD, Make B, Regan E, Han M, Hersh CP, Tal-Singer R, Quackenbush J, Choi AMK, Silverman EK, DeMeo DL. DNA Methylation Is Predictive of Mortality in Current and Former Smokers. Am J Respir Crit Care Med. 2020 05 01; 201(9):1099-1109. PMID: 31995399; PMCID: PMC7193844.
    Citations: 7     Fields:    Translation:HumansCells
  43. Paci P, Fiscon G, Conte F, Licursi V, Morrow J, Hersh C, Cho M, Castaldi P, Glass K, Silverman EK, Farina L. Integrated transcriptomic correlation network analysis identifies COPD molecular determinants. Sci Rep. 2020 02 25; 10(1):3361. PMID: 32099002.
    Citations: 14     Fields:    Translation:HumansCells
  44. Hersh CP, Zacharia S, Prakash Arivu Chelvan R, Hayden LP, Mirtar A, Zarei S, Putcha N. Immunoglobulin E as a Biomarker for the Overlap of Atopic Asthma and Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2020 Jan; 7(1):1-12. PMID: 31999898.
    Citations: 9     
  45. Castaldi PJ, Boueiz A, Yun J, Estepar RSJ, Ross JC, Washko G, Cho MH, Hersh CP, Kinney GL, Young KA, Regan EA, Lynch DA, Criner GJ, Dy JG, Rennard SI, Casaburi R, Make BJ, Crapo J, Silverman EK, Hokanson JE. Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study. Chest. 2020 05; 157(5):1147-1157. PMID: 31887283; PMCID: PMC7242638.
    Citations: 13     Fields:    Translation:Humans
  46. Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ. Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2019 11 18; 12(1):166. PMID: 31739789.
    Citations:    Fields:    
  47. Lowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas Sánchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399. PMID: 31710793; PMCID: PMC7020846.
    Citations: 53     
  48. Shi WJ, Zhuang Y, Russell PH, Hobbs BD, Parker MM, Castaldi PJ, Rudra P, Vestal B, Hersh CP, Saba LM, Kechris K. Unsupervised discovery of phenotype-specific multi-omics networks. Bioinformatics. 2019 11 01; 35(21):4336-4343. PMID: 30957844.
    Citations: 9     Fields:    Translation:HumansCells
  49. Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690. PMID: 30908940; PMCID: PMC6775891.
    Citations: 23     Fields:    Translation:Humans
  50. Yun JH, Chase R, Parker MM, Saferali A, Castaldi PJ, Silverman EK, Hersh CP. Peripheral Blood Gene Expression Signatures of Eosinophilic Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 09; 61(3):398-401. PMID: 31469299; PMCID: PMC6839929.
    Citations: 2     Fields:    Translation:HumansCells
  51. Christenson S, Hersh CP. Found in Translation: Multi-omics Assessment of the Chronic Obstructive Pulmonary Disease-Lung Cancer Interaction. Am J Respir Crit Care Med. 2019 Aug 01; 200(3):276-277. PMID: 30753788; PMCID: PMC6680298.
    Citations: 2     Fields:    Translation:Humans
  52. Regan EA, Hersh CP, Castaldi PJ, DeMeo DL, Silverman EK, Crapo JD, Bowler RP. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 08; 61(2):143-149. PMID: 30874442; PMCID: PMC6670029.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  53. Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San José Estépar R, Zhou X, Castaldi PJ. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 07 25; 8. PMID: 31343404.
    Citations: 13     Fields:    Translation:HumansCells
  54. Balasubramanian A, MacIntyre NR, Henderson RJ, Jensen RL, Kinney G, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Barr RG, Make BJ, Wise RA, McCormack MC. Diffusing Capacity of Carbon Monoxide in Assessment of COPD. Chest. 2019 12; 156(6):1111-1119. PMID: 31352035; PMCID: PMC7242635.
    Citations: 17     Fields:    Translation:Humans
  55. Saferali A, Yun JH, Parker MM, Sakornsakolpat P, Chase RP, Lamb A, Hobbs BD, Boezen MH, Dai X, de Jong K, Beaty TH, Wei W, Zhou X, Silverman EK, Cho MH, Castaldi PJ, Hersh CP. Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. PLoS Genet. 2019 07; 15(7):e1008229. PMID: 31269066.
    Citations: 9     Fields:    Translation:HumansCells
  56. Fortis S, Comellas A, Make BJ, Hersh CP, Bodduluri S, Georgopoulos D, Kim V, Criner GJ, Dransfield MT, Bhatt SP. Combined Forced Expiratory Volume in 1 Second and Forced Vital Capacity Bronchodilator Response, Exacerbations, and Mortality in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2019 07; 16(7):826-835. PMID: 30908927.
    Citations: 13     Fields:    Translation:Humans
  57. Maselli DJ, Bhatt SP, Anzueto A, Bowler RP, DeMeo DL, Diaz AA, Dransfield MT, Fawzy A, Foreman MG, Hanania NA, Hersh CP, Kim V, Kinney GL, Putcha N, Wan ES, Wells JM, Westney GE, Young KA, Silverman EK, Han MK, Make BJ. Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study. Chest. 2019 08; 156(2):228-238. PMID: 31154041; PMCID: PMC7198872.
    Citations: 22     Fields:    Translation:Humans
  58. McDonald MN, Wouters EFM, Rutten E, Casaburi R, Rennard SI, Lomas DA, Bamman M, Celli B, Agusti A, Tal-Singer R, Hersh CP, Dransfield M, Silverman EK. It's more than low BMI: prevalence of cachexia and associated mortality in COPD. Respir Res. 2019 May 22; 20(1):100. PMID: 31118043.
    Citations: 23     Fields:    Translation:Humans
  59. Lutz SM, Frederiksen B, Begum F, McDonald MN, Cho MH, Hobbs BD, Parker MM, DeMeo DL, Hersh CP, Ehringer MA, Young K, Jiang L, Foreman MG, Kinney GL, Make BJ, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, Hokanson JE. Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. Nicotine Tob Res. 2019 05 21; 21(6):714-722. PMID: 29767774; PMCID: PMC6528143.
    Citations: 6     Fields:    Translation:Humans
  60. Hersh CP. Pharmacogenomics of chronic obstructive pulmonary disease. Expert Rev Respir Med. 2019 05; 13(5):459-470. PMID: 30925849.
    Citations:    Fields:    Translation:Humans
  61. Morrow JD, Chase RP, Parker MM, Glass K, Seo M, Divo M, Owen CA, Castaldi P, DeMeo DL, Silverman EK, Hersh CP. RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. Respir Res. 2019 Apr 02; 20(1):65. PMID: 30940135.
    Citations: 21     Fields:    Translation:HumansCells
  62. Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398. PMID: 30335480; PMCID: PMC6444627.
    Citations: 6     Fields:    Translation:HumansCells
  63. Zhang Z, Yu D, Seo M, Hersh CP, Weiss ST, Qiu W. Novel Data Transformations for RNA-seq Differential Expression Analysis. Sci Rep. 2019 03 18; 9(1):4820. PMID: 30886278.
    Citations: 4     Fields:    Translation:Humans
  64. Hersh CP, Campbell EJ, Scott LR, Raby BA. Alpha-1 Antitrypsin Deficiency as an Incidental Finding in Clinical Genetic Testing. Am J Respir Crit Care Med. 2019 01 15; 199(2):246-248. PMID: 30359090; PMCID: PMC6353005.
    Citations: 3     Fields:    Translation:Humans
  65. Faner R, Morrow JD, Casas-Recasens S, Cloonan SM, Noell G, López-Giraldo A, Tal-Singer R, Miller BE, Silverman EK, Agustí A, Hersh CP. Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis. Respir Res. 2019 Jan 08; 20(1):5. PMID: 30621695; PMCID: PMC6325784.
    Citations: 3     Fields:    Translation:HumansCells
  66. Hersh CP, Adcock IM, Celedón JC, Cho MH, Christiani DC, Himes BE, Kaminski N, Mathias RA, Meyers DA, Quackenbush J, Redline S, Steiling KA, Tabor HK, Tobin MD, Wurfel MM, Yang IV, Koppelman GH. High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2019 01; 16(1):1-16. PMID: 30592451.
    Citations: 5     Fields:    Translation:Humans
  67. Jang YJ, Seo M, Hersh CP, Rhee SJ, Kim Y, Lee GP. An evolutionarily conserved non-synonymous SNP in a leucine-rich repeat domain determines anthracnose resistance in watermelon. Theor Appl Genet. 2019 Feb; 132(2):473-488. PMID: 30446794.
    Citations: 4     Fields:    Translation:AnimalsCells
  68. Huang T, Glass K, Zeleznik OA, Kang JH, Ivey KL, Sonawane AR, Birmann BM, Hersh CP, Hu FB, Tworoger SS. A Network Analysis of Biomarkers for Type 2 Diabetes. Diabetes. 2019 02; 68(2):281-290. PMID: 30409783; PMCID: PMC6341308.
    Citations: 12     Fields:    Translation:Humans
  69. Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH. Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812. PMID: 30060175; PMCID: PMC6196654.
    Citations: 12     Fields:    Translation:Humans
  70. Hayden LP, Cho MH, Raby BA, Beaty TH, Silverman EK, Hersh CP. Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study. Respir Res. 2018 Oct 29; 19(1):209. PMID: 30373671; PMCID: PMC6206739.
    Citations: 13     Fields:    Translation:Humans
  71. Seo M, Qiu W, Bailey W, Criner GJ, Dransfield MT, Fuhlbrigge AL, Reilly JJ, Scholand MB, Castaldi P, Chase R, Parker M, Saferali A, Yun JH, Crapo JD, Cho MH, Beaty TH, Silverman EK, Hersh CP. Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease. J Mol Med (Berl). 2018 12; 96(12):1375-1385. PMID: 30353303; PMCID: PMC6240374.
    Citations: 5     Fields:    Translation:Humans
  72. Ross JC, Castaldi PJ, Cho MH, Hersh CP, Rahaghi FN, Sánchez-Ferrero GV, Parker MM, Litonjua AA, Sparrow D, Dy JG, Silverman EK, Washko GR, San José Estépar R. Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 10 15; 198(8):1033-1042. PMID: 29671603; PMCID: PMC6221566.
    Citations: 15     Fields:    Translation:Humans
  73. Yun JH, Hersh CP. Reply. J Allergy Clin Immunol. 2018 12; 142(6):2013-2014. PMID: 30316523.
    Citations:    Fields:    Translation:HumansCells
  74. Maselli DJ, Hardin M, Christenson SA, Hanania NA, Hersh CP, Adams SG, Anzueto A, Peters JI, Han MK, Martinez FJ. Clinical Approach to the Therapy of Asthma-COPD Overlap. Chest. 2019 01; 155(1):168-177. PMID: 30077690; PMCID: PMC6688980.
    Citations: 14     Fields:    Translation:Humans
  75. Morrow JD, Glass K, Cho MH, Hersh CP, Pinto-Plata V, Celli B, Marchetti N, Criner G, Bueno R, Washko G, Choi AMK, Quackenbush J, Silverman EK, DeMeo DL. Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci. Am J Respir Crit Care Med. 2018 05 15; 197(10):1275-1284. PMID: 29313708; PMCID: PMC5955059.
    Citations: 19     Fields:    Translation:HumansCells
  76. Yun JH, Lamb A, Chase R, Singh D, Parker MM, Saferali A, Vestbo J, Tal-Singer R, Castaldi PJ, Silverman EK, Hersh CP. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018 06; 141(6):2037-2047.e10. PMID: 29709670.
    Citations: 58     Fields:    Translation:HumansCells
  77. Sakornsakolpat P, Morrow JD, Castaldi PJ, Hersh CP, Bossé Y, Silverman EK, Manichaikul A, Cho MH. Integrative genomics identifies new genes associated with severe COPD and emphysema. Respir Res. 2018 03 22; 19(1):46. PMID: 29566699; PMCID: PMC5863845.
    Citations: 7     Fields:    Translation:Humans
  78. Carr LL, Jacobson S, Lynch DA, Foreman MG, Flenaugh EL, Hersh CP, Sciurba FC, Wilson DO, Sieren JC, Mulhall P, Kim V, Kinsey CM, Bowler RP. Features of COPD as Predictors of Lung Cancer. Chest. 2018 06; 153(6):1326-1335. PMID: 29452098; PMCID: PMC6026288.
    Citations: 24     Fields:    Translation:Humans
  79. Morrow JD, Cho MH, Platig J, Zhou X, DeMeo DL, Qiu W, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Silverman EK, Hersh CP. Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease. Hum Genomics. 2018 01 15; 12(1):1. PMID: 29335020; PMCID: PMC5769240.
    Citations: 10     Fields:    Translation:Humans
  80. Hayden LP, Hardin ME, Qiu W, Lynch DA, Strand MJ, van Beek EJ, Crapo JD, Silverman EK, Hersh CP. Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study. Chest. 2018 02; 153(2):368-377. PMID: 29248621.
    Citations: 5     Fields:    Translation:Humans
  81. McDonald MN, Diaz AA, Rutten E, Lutz SM, Harmouche R, San Jose Estepar R, Kinney G, Hokanson JE, Gower BA, Wouters EFM, Rennard SI, Hersh CP, Casaburi R, Dransfield MT, Silverman EK, Washko GR. Chest computed tomography-derived low fat-free mass index and mortality in COPD. Eur Respir J. 2017 Dec; 50(6). PMID: 29242259; PMCID: PMC5890424.
    Citations: 18     Fields:    Translation:Humans
  82. Schlauch D, Glass K, Hersh CP, Silverman EK, Quackenbush J. Estimating drivers of cell state transitions using gene regulatory network models. BMC Syst Biol. 2017 Dec 13; 11(1):139. PMID: 29237467.
    Citations: 5     Fields:    Translation:Humans
  83. Hersh CP. Diagnosing alpha-1 antitrypsin deficiency: the first step in precision medicine. F1000Res. 2017; 6:2049. PMID: 29225784.
    Citations: 3     Fields:    
  84. Bradford E, Jacobson S, Varasteh J, Comellas AP, Woodruff P, O'Neal W, DeMeo DL, Li X, Kim V, Cho M, Castaldi PJ, Hersh C, Silverman EK, Crapo JD, Kechris K, Bowler RP. The value of blood cytokines and chemokines in assessing COPD. Respir Res. 2017 10 24; 18(1):180. PMID: 29065892.
    Citations: 41     Fields:    Translation:HumansCTClinical Trials
  85. Reinhold D, Morrow JD, Jacobson S, Hu J, Ringel B, Seibold MA, Hersh CP, Kechris KJ, Bowler RP. Meta-analysis of peripheral blood gene expression modules for COPD phenotypes. PLoS One. 2017; 12(10):e0185682. PMID: 29016655.
    Citations: 11     Fields:    Translation:HumansCells
  86. Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ. RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2017 10 06; 10(1):58. PMID: 28985737.
    Citations: 32     Fields:    Translation:Humans
  87. Foreman MG, Wilson C, DeMeo DL, Hersh CP, Beaty TH, Cho MH, Ziniti J, Curran-Everett D, Criner G, Hokanson JE, Brantly M, Rouhani FN, Sandhaus RA, Crapo JD, Silverman EK. Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups. Ann Am Thorac Soc. 2017 Aug; 14(8):1280-1287. PMID: 28380308; PMCID: PMC5566271.
    Citations: 26     Fields:    Translation:Humans
  88. Hersh CP, Vachani A. Whole-Genome Sequencing in Common Respiratory Diseases. Ready, Set, Go! Am J Respir Crit Care Med. 2017 07 15; 196(2):121-122. PMID: 28707973; PMCID: PMC5519974.
    Citations: 2     Fields:    Translation:Humans
  89. Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP. Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol. 2017 07; 57(1):47-58. PMID: 28248572; PMCID: PMC5516276.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  90. Castaldi PJ, Benet M, Petersen H, Rafaels N, Finigan J, Paoletti M, Marike Boezen H, Vonk JM, Bowler R, Pistolesi M, Puhan MA, Anto J, Wauters E, Lambrechts D, Janssens W, Bigazzi F, Camiciottoli G, Cho MH, Hersh CP, Barnes K, Rennard S, Boorgula MP, Dy J, Hansel NN, Crapo JD, Tesfaigzi Y, Agusti A, Silverman EK, Garcia-Aymerich J. Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts. Thorax. 2017 11; 72(11):998-1006. PMID: 28637835.
    Citations: 26     Fields:    Translation:Humans
  91. Obeidat M, Nie Y, Chen V, Shannon CP, Andiappan AK, Lee B, Rotzschke O, Castaldi PJ, Hersh CP, Fishbane N, Ng RT, McManus B, Miller BE, Rennard S, Paré PD, Sin DD. Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease. Respir Res. 2017 04 24; 18(1):72. PMID: 28438154.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  92. Castaldi PJ, Cho MH, Liang L, Silverman EK, Hersh CP, Rice K, Aschard H. Screening for interaction effects in gene expression data. PLoS One. 2017; 12(3):e0173847. PMID: 28301596.
    Citations: 2     Fields:    
  93. Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771. PMID: 27669027; PMCID: PMC5363968.
    Citations: 23     Fields:    Translation:Humans
  94. Morrow JD, Zhou X, Lao T, Jiang Z, DeMeo DL, Cho MH, Qiu W, Cloonan S, Pinto-Plata V, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Choi AM, Silverman EK, Hersh CP. Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Sci Rep. 2017 03 13; 7:44232. PMID: 28287180.
    Citations: 50     Fields:    Translation:HumansAnimalsCTClinical Trials
  95. Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341. PMID: 27854507.
    Citations: 17     Fields:    Translation:Humans
  96. Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 05; 41(4):309-319. PMID: 28191685; PMCID: PMC5397337.
    Citations: 9     Fields:    Translation:Humans
  97. Zarei S, Mirtar A, Morrow JD, Castaldi PJ, Belloni P, Hersh CP. Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics. Chronic Obstr Pulm Dis. 2017 Feb 08; 4(2):97-108. PMID: 28848918.
    Citations: 1     
  98. McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436. PMID: 28044437.
    Citations: 8     Fields:    Translation:Humans
  99. Hayden LP, Cho MH, McDonald MN, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis. Am J Respir Cell Mol Biol. 2017 01; 56(1):20-28. PMID: 27508494.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  100. Wells JM, Estepar RS, McDonald MN, Bhatt SP, Diaz AA, Bailey WC, Jacobson FL, Dransfield MT, Washko GR, Make BJ, Casaburi R, van Beek EJ, Hoffman EA, Sciurba FC, Crapo JD, Silverman EK, Hersh CP. Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med. 2016 12 01; 16(1):169. PMID: 27903260.
    Citations: 10     Fields:    Translation:Humans
  101. Morrow JD, Cho MH, Hersh CP, Pinto-Plata V, Celli B, Marchetti N, Criner G, Bueno R, Washko G, Glass K, Choi AMK, Quackenbush J, Silverman EK, DeMeo DL. DNA methylation profiling in human lung tissue identifies genes associated with COPD. Epigenetics. 2016 Oct 02; 11(10):730-739. PMID: 27564456.
    Citations: 34     Fields:    
  102. Cosentino J, Zhao H, Hardin M, Hersh CP, Crapo J, Kim V, Criner GJ. Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc. 2016 09; 13(9):1483-9. PMID: 27268723; PMCID: PMC5614769.
    Citations: 23     Fields:    Translation:Humans
  103. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011. PMID: 27532455.
    Citations: 50     Fields:    Translation:Humans
  104. Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agustí A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH. Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 01; 194(1):48-57. PMID: 26771213; PMCID: PMC4960630.
    Citations: 26     Fields:    Translation:Humans
  105. Qiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, Hersh CP, Morrow J, Pinto-Plata VM, Marchetti N, Bueno R, Celli BR, Criner GJ, Silverman EK, Cho MH. Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1353-63. PMID: 26736064; PMCID: PMC4910887.
    Citations: 24     Fields:    Translation:Humans
  106. Busch R, Han MK, Bowler RP, Dransfield MT, Wells JM, Regan EA, Hersh CP. Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med. 2016 Feb 10; 16:28. PMID: 26861867.
    Citations: 10     Fields:    Translation:Humans
  107. Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138. PMID: 26634245; PMCID: PMC4668640.
    Citations: 69     Fields:    Translation:HumansCellsCTClinical Trials
  108. Hardin M, Cho MH, McDonald ML, Wan E, Lomas DA, Coxson HO, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Bhatt SP, Kim V, Ramsdell J, Regan EA, Make BJ, Hokanson JE, Crapo JD, Beaty TH, Hersh CP. A genome-wide analysis of the response to inhaled ß2-agonists in chronic obstructive pulmonary disease. Pharmacogenomics J. 2016 08; 16(4):326-35. PMID: 26503814; PMCID: PMC4848212.
    Citations: 11     Fields:    Translation:Humans
  109. Hayden LP, Hobbs BD, Cohen RT, Wise RA, Checkley W, Crapo JD, Hersh CP. Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study. Respir Res. 2015 Sep 21; 16:115. PMID: 26392057; PMCID: PMC4578796.
    Citations: 26     Fields:    Translation:Humans
  110. Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San José Estépar R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):559-69. PMID: 26030696; PMCID: PMC4595690.
    Citations: 72     Fields:    Translation:Humans
  111. Park SJ, Make B, Hersh CP, Bowler RP. Significance of Medication History at the Time of Entry into the COPDGene Study: Relationship with Exacerbation and CT Metrics. COPD. 2015 Aug; 12(4):366-73. PMID: 25254928.
    Citations: 3     Fields:    Translation:Humans
  112. Lee JH, Cho MH, Hersh CP, McDonald ML, Wells JM, Dransfield MT, Bowler RP, Lynch DA, Lomas DA, Crapo JD, Silverman EK. IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2015 Mar; 52(3):365-76. PMID: 25101718; PMCID: PMC4370263.
    Citations: 14     Fields:    Translation:Humans
  113. Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 2015; 7(1):12. PMID: 25763110; PMCID: PMC4355149.
    Citations: 28     Fields:    
  114. Morrow JD, Qiu W, Chhabra D, Rennard SI, Belloni P, Belousov A, Pillai SG, Hersh CP. Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods. BMC Med Genomics. 2015 Jan 13; 8:1. PMID: 25582225.
    Citations: 31     Fields:    Translation:HumansCells
  115. McDonald ML, Cho MH, Sørheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87. PMID: 24825563; PMCID: PMC4224086.
    Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
  116. Hobbs BD, Foreman MG, Bowler R, Jacobson F, Make BJ, Castaldi PJ, San José Estépar R, Silverman EK, Hersh CP. Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014 Nov; 11(9):1387-94. PMID: 25295410; PMCID: PMC4298989.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  117. Diaz AA, Hardin ME, Come CE, San José Estépar R, Ross JC, Kurugol S, Okajima Y, Han MK, Kim V, Ramsdell J, Silverman EK, Crapo JD, Lynch DA, Make B, Barr RG, Hersh CP, Washko GR. Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. Ann Am Thorac Soc. 2014 Nov; 11(9):1371-8. PMID: 25296268.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  118. Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek E, Silverman EK, Crapo JD. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014 Oct 24; 14:164. PMID: 25341556.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  119. Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10. PMID: 25315895; PMCID: PMC4806382.
    Citations: 24     Fields:    Translation:HumansCells
  120. Carolan BJ, Hughes G, Morrow J, Hersh CP, O'Neal WK, Rennard S, Pillai SG, Belloni P, Cockayne DA, Comellas AP, Han M, Zemans RL, Kechris K, Bowler RP. The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. Respir Res. 2014 Oct 12; 15:127. PMID: 25306249.
    Citations: 36     Fields:    Translation:Humans
  121. Bowler RP, Kim V, Regan E, Williams AAA, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath HP, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJR, Wilson C, Wendt C, Wise RA. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Oct; 146(4):941-950. PMID: 24945159; PMCID: PMC4188150.
    Citations: 50     Fields:    Translation:Humans
  122. Lee JH, Cho MH, Hersh CP, McDonald ML, Crapo JD, Bakke PS, Gulsvik A, Comellas AP, Wendt CH, Lomas DA, Kim V, Silverman EK. Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res. 2014 Sep 21; 15:113. PMID: 25241909; PMCID: PMC4190389.
    Citations: 28     Fields:    Translation:HumansCells