Harvard Catalyst Profiles

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Andrew C. Keates, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee J, Keates AC, Li CJ. Synthetic Biology Medicine and Bacteria-Based Cancer Therapeutics. Methods Mol Biol. 2021; 2323:267-280. PMID: 34086287.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Ghisolfi L, Keates AC, Hu X, Lee DK, Li CJ. Ionizing radiation induces stemness in cancer cells. PLoS One. 2012; 7(8):e43628. PMID: 22928007.
    Citations: 81     Fields:    Translation:HumansCells
  3. Sperling T, Oldak M, Walch-Rückheim B, Wickenhauser C, Doorbar J, Pfister H, Malejczyk M, Majewski S, Keates AC, Smola S. Human papillomavirus type 8 interferes with a novel C/EBPß-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration. PLoS Pathog. 2012; 8(7):e1002833. PMID: 22911498; PMCID: PMC3406103.
    Citations: 44     Fields:    Translation:HumansCells
  4. Hu X, Ghisolfi L, Keates AC, Zhang J, Xiang S, Lee DK, Li CJ. Induction of cancer cell stemness by chemotherapy. Cell Cycle. 2012 Jul 15; 11(14):2691-8. PMID: 22732500.
    Citations: 46     Fields:    Translation:HumansCells
  5. Li C, Li L, Keates AC. Targeting cancer gene therapy with magnetic nanoparticles. Oncotarget. 2012 Apr; 3(4):365-70. PMID: 22562943.
    Citations: 15     Fields:    Translation:HumansAnimals
  6. Guo H, Zhang J, Inal C, Nguyen T, Fruehauf JH, Keates AC, Li CJ. Targeting tumor gene by shRNA-expressing Salmonella-mediated RNAi. Gene Ther. 2011 Jan; 18(1):95-105. PMID: 20811467.
    Citations: 7     Fields:    Translation:AnimalsCells
  7. Xiang S, Keates AC, Fruehauf J, Yang Y, Guo H, Nguyen T, Li CJ. In vitro and in vivo gene silencing by TransKingdom RNAi (tkRNAi). Methods Mol Biol. 2009; 487:147-60. PMID: 19301646.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Keates AC, Tummala S, Peek RM, Csizmadia E, Kunzli B, Becker K, Correa P, Romero-Gallo J, Piazuelo MB, Sheth S, Kelly CP, Robson SC, Keates S. Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells. Infect Immun. 2008 Sep; 76(9):3992-9. PMID: 18519558.
    Citations: 10     Fields:    Translation:HumansCells
  9. Keates AC, Fruehauf J, Xiang S, Li CJ. TransKingdom RNA interference: a bacterial approach to challenges in RNAi therapy and delivery. Biotechnol Genet Eng Rev. 2008; 25:113-27. PMID: 21412352.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Keates S, Han X, Kelly CP, Keates AC. Macrophage-inflammatory protein-3alpha mediates epidermal growth factor receptor transactivation and ERK1/2 MAPK signaling in Caco-2 colonic epithelial cells via metalloproteinase-dependent release of amphiregulin. J Immunol. 2007 Jun 15; 178(12):8013-21. PMID: 17548638.
    Citations: 13     Fields:    Translation:HumansCells
  11. Keates S, Keates AC, Katchar K, Peek RM, Kelly CP. Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis. 2007 Jul 01; 196(1):95-103. PMID: 17538889.
    Citations: 25     Fields:    Translation:HumansCells
  12. Katchar K, Kelly CP, Keates S, O'brien MJ, Keates AC. MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1263-71. PMID: 17272517.
    Citations: 25     Fields:    Translation:AnimalsCells
  13. Kwon JH, Keates AC, Anton PM, Botero M, Goldsmith JD, Kelly CP. Topical antisense oligonucleotide therapy against LIX, an enterocyte-expressed CXC chemokine, reduces murine colitis. Am J Physiol Gastrointest Liver Physiol. 2005 Dec; 289(6):G1075-83. PMID: 16099872.
    Citations: 18     Fields:    Translation:AnimalsCells
  14. Keates S, Keates AC, Nath S, Peek RM, Kelly CP. Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut. 2005 Oct; 54(10):1363-9. PMID: 15863471; PMCID: PMC1774684.
    Citations: 20     Fields:    Translation:HumansCells
  15. Rhee SH, Keates AC, Moyer MP, Pothoulakis C. MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. J Biol Chem. 2004 Jun 11; 279(24):25179-88. PMID: 15069060.
    Citations: 39     Fields:    Translation:HumansCells
  16. Kwon JH, Keates S, Bassani L, Mayer LF, Keates AC. Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease. Gut. 2002 Dec; 51(6):818-26. PMID: 12427784; PMCID: PMC1773480.
    Citations: 51     Fields:    Translation:HumansCells
  17. Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):875-84. PMID: 12414801.
    Citations: 23     Fields:    Translation:HumansCells
  18. Farrell RJ, Menconi MJ, Keates AC, Kelly CP. P-glycoprotein-170 inhibition significantly reduces cortisol and ciclosporin efflux from human intestinal epithelial cells and T lymphocytes. Aliment Pharmacol Ther. 2002 May; 16(5):1021-31. PMID: 11966513.
    Citations: 14     Fields:    Translation:HumansCells
  19. Castagliuolo I, Morteau O, Keates AC, Valenick L, Wang CC, Zacks J, Lu B, Gerard NP, Pothoulakis C. Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor. Br J Pharmacol. 2002 May; 136(2):271-9. PMID: 12010776; PMCID: PMC1573337.
    Citations: 30     Fields:    Translation:Animals
  20. He D, Sougioultzis S, Hagen S, Liu J, Keates S, Keates AC, Pothoulakis C, Lamont JT. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology. 2002 Apr; 122(4):1048-57. PMID: 11910356.
    Citations: 44     Fields:    Translation:HumansCells
  21. de Jong YP, Abadia-Molina AC, Satoskar AR, Clarke K, Rietdijk ST, Faubion WA, Mizoguchi E, Metz CN, Alsahli M, ten Hove T, Keates AC, Lubetsky JB, Farrell RJ, Michetti P, van Deventer SJ, Lolis E, David JR, Bhan AK, Terhorst C, Sahli MA. Development of chronic colitis is dependent on the cytokine MIF. Nat Immunol. 2001 Nov; 2(11):1061-6. PMID: 11668338.
    Citations: 108     Fields:    Translation:HumansAnimals
  22. Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM, Shaw LM, Kelly CP. cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem. 2001 Dec 21; 276(51):48127-34. PMID: 11604402.
    Citations: 76     Fields:    Translation:HumansCells
  23. Zhao D, Keates AC, Kuhnt-Moore S, Moyer MP, Kelly CP, Pothoulakis C. Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes. J Biol Chem. 2001 Nov 30; 276(48):44464-71. PMID: 11574537.
    Citations: 47     Fields:    Translation:HumansCells
  24. Keates AC, Keates S, Kwon JH, Arseneau KO, Law DJ, Bai L, Merchant JL, Wang TC, Kelly CP. ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2001 Nov 23; 276(47):43713-22. PMID: 11559712.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  25. Keates AC, Castagliuolo I, Cruickshank WW, Qiu B, Arseneau KO, Brazer W, Kelly CP. Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice. Gastroenterology. 2000 Oct; 119(4):972-82. PMID: 11040184.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  26. Warny M, Keates AC, Keates S, Castagliuolo I, Zacks JK, Aboudola S, Qamar A, Pothoulakis C, LaMont JT, Kelly CP. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest. 2000 Apr; 105(8):1147-56. PMID: 10772660; PMCID: PMC300827.
    Citations: 81     Fields:    Translation:AnimalsCells
  27. Keates S, Keates AC, Warny M, Peek RM, Murray PG, Kelly CP. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J Immunol. 1999 Nov 15; 163(10):5552-9. PMID: 10553083.
    Citations: 82     Fields:    Translation:HumansCells
  28. Offner GD, Nunes DP, Keates AC, Afdhal NH, Troxler RF. The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. Biochem Biophys Res Commun. 1998 Oct 09; 251(1):350-5. PMID: 9790959.
    Citations: 5     Fields:    Translation:HumansCells
  29. Castagliuolo I, Keates AC, Wang CC, Pasha A, Valenick L, Kelly CP, Nikulasson ST, LaMont JT, Pothoulakis C. Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells. J Immunol. 1998 Jun 15; 160(12):6039-45. PMID: 9637520.
    Citations: 38     Fields:    Translation:AnimalsCells
  30. Keates AC, Castagliuolo I, Qiu B, Nikulasson S, Sengupta A, Pothoulakis C. CGRP upregulation in dorsal root ganglia and ileal mucosa during Clostridium difficile toxin A-induced enteritis. Am J Physiol. 1998 01; 274(1):G196-202. PMID: 9458790.
    Citations: 12     Fields:    Translation:AnimalsCells
  31. Linevsky JK, Pothoulakis C, Keates S, Warny M, Keates AC, Lamont JT, Kelly CP. IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. Am J Physiol. 1997 12; 273(6):G1333-40. PMID: 9435559.
    Citations: 34     Fields:    Translation:HumansCells
  32. Keates S, Keates AC, Mizoguchi E, Bhan A, Kelly CP. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol. 1997 Jul; 273(1 Pt 1):G75-82. PMID: 9252512.
    Citations: 31     Fields:    Translation:HumansCells
  33. Keates AC, Nunes DP, Afdhal NH, Troxler RF, Offner GD. Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem J. 1997 May 15; 324 ( Pt 1):295-303. PMID: 9164870; PMCID: PMC1218430.
    Citations: 18     Fields:    Translation:HumansCells
  34. Castagliuolo I, Keates AC, Qiu B, Kelly CP, Nikulasson S, Leeman SE, Pothoulakis C. Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4788-93. PMID: 9114070; PMCID: PMC20803.
    Citations: 49     Fields:    Translation:AnimalsCells
  35. Nunes DP, Keates AC, Afdhal NH, Offner GD. Bovine gall-bladder mucin contains two distinct tandem repeating sequences: evidence for scavenger receptor cysteine-rich repeats. Biochem J. 1995 Aug 15; 310 ( Pt 1):41-8. PMID: 7646470; PMCID: PMC1135851.
    Citations: 5     Fields:    Translation:AnimalsCells
  36. Brown JF, Keates AC, Hanson PJ, Whittle BJ. Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells. Am J Physiol. 1993 Sep; 265(3 Pt 1):G418-22. PMID: 8214062.
    Citations: 42     Fields:    Translation:Animals
  37. Keates AC, Bailey CJ. Metformin does not increase energy expenditure of brown fat. Biochem Pharmacol. 1993 Feb 24; 45(4):971-3. PMID: 8383971.
    Citations: 1     Fields:    Translation:AnimalsCells
  38. Keates AC, Williams JM, Hanson PJ. Activation of intracellular signalling pathways induces secretion of mucin by isolated rat gastric mucosal cells. Biochem Soc Trans. 1992 May; 20(2):183S. PMID: 1327909.
    Citations:    Fields:    Translation:AnimalsCells
  39. Keates AC, Hanson PJ. Assay of mucus secreted from isolated stomach cells by using an enzyme-linked immunosorbent assay. Biochem Soc Trans. 1990 Oct; 18(5):956. PMID: 2083763.
    Citations:    Fields:    Translation:Animals
  40. Keates AC, Hanson PJ. Regulation of mucus secretion by cells isolated from the rat gastric mucosa. J Physiol. 1990 Apr; 423:397-409. PMID: 2388155; PMCID: PMC1189764.
    Citations: 3     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.