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profileNorbert Perrimon, Ph.D.

TitleJames Stillman Professor of Developmental Biology
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard, FAS Molecular & Cell Biology
200 Longwood Ave
Boston MA 02115
Phone617/432-7672
Fax617/432-7688
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fagegaltier D, Falciatori I, Czech B, Castel S, Perrimon N, Simcox A, Hannon GJ. Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway. Genes Dev. 2016 Jul 15; 30(14):1623-35. PMID: 27474441.
    View in: PubMed
  2. Parkhitko AA, Binari R, Zhang N, Asara JM, Demontis F, Perrimon N. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Genes Dev. 2016 Jun 15; 30(12):1409-22. PMID: 27313316.
    View in: PubMed
  3. Housden BE, Perrimon N. Comparing CRISPR and RNAi-based screening technologies. Nat Biotechnol. 2016 Jun 9; 34(6):621-3. PMID: 27281421.
    View in: PubMed
  4. Hunter GL, Hadjivasiliou Z, Bonin H, He L, Perrimon N, Charras G, Baum B. Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Development. 2016 Jul 1; 143(13):2305-10. PMID: 27226324.
    View in: PubMed
  5. Harris KP, Zhang YV, Piccioli ZD, Perrimon N, Littleton JT. The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling. Elife. 2016; 5. PMID: 27223326.
    View in: PubMed
  6. De Lella Ezcurra AL, Bertolin AP, Kim K, Katz MJ, Gándara L, Misra T, Luschnig S, Perrimon N, Melani M, Wappner P. miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga. PLoS Genet. 2016 May; 12(5):e1006073. PMID: 27223464.
    View in: PubMed
  7. Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJ, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G. Comparison of Cas9 activators in multiple species. Nat Methods. 2016 Jul; 13(7):563-7. PMID: 27214048.
    View in: PubMed
  8. Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y, Kwon Y, Sharma A, Liu YY, Perrimon N, Barabási AL. Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets. Proc Natl Acad Sci U S A. 2016 May 3; 113(18):4976-81. PMID: 27091990.
    View in: PubMed
  9. Perrimon N, Bonini NM, Dhillon P. Fruit flies on the front line: the translational impact of Drosophila. Dis Model Mech. 2016 Mar 1; 9(3):229-31. PMID: 26935101.
    View in: PubMed
  10. Breitkopf SB, Yang X, Begley MJ, Kulkarni M, Chiu YH, Turke AB, Lauriol J, Yuan M, Qi J, Engelman JA, Hong P, Kontaridis MI, Cantley LC, Perrimon N, Asara JM. A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2. Sci Rep. 2016; 6:20471. PMID: 26839216.
    View in: PubMed
  11. Ma M, Zhao H, Zhao H, Binari R, Perrimon N, Li Z. Wildtype adult stem cells, unlike tumor cells, are resistant to cellular damages in Drosophila. Dev Biol. 2016 Mar 15; 411(2):207-16. PMID: 26845534.
    View in: PubMed
  12. Doupé DP, Perrimon N. Toward a Systems Understanding of Signaling Pathway Function. Curr Top Dev Biol. 2016; 117:221-36. PMID: 26969980.
    View in: PubMed
  13. Jodoin JN, Coravos JS, Chanet S, Vasquez CG, Tworoger M, Kingston ER, Perkins LA, Perrimon N, Martin AC. Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Dev Cell. 2015 Dec 21; 35(6):685-97. PMID: 26688336.
    View in: PubMed
  14. Dequéant ML, Fagegaltier D, Hu Y, Spirohn K, Simcox A, Hannon GJ, Perrimon N. Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):12974-9. PMID: 26438832; PMCID: PMC4620889 [Available on 04/20/16].
  15. Kuhn H, Sopko R, Coughlin M, Perrimon N, Mitchison T. The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos. Development. 2015 Nov 15; 142(22):3869-78. PMID: 26395483.
    View in: PubMed
  16. Owusu-Ansah E, Perrimon N. Stress Signaling Between Organs in Metazoa. Annu Rev Cell Dev Biol. 2015 Nov 13; 31:497-522. PMID: 26393775.
    View in: PubMed
  17. Chen CL, Hu Y, Udeshi ND, Lau TY, Wirtz-Peitz F, He L, Ting AY, Carr SA, Perrimon N. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Proc Natl Acad Sci U S A. 2015 Sep 29; 112(39):12093-8. PMID: 26362788; PMCID: PMC4593093 [Available on 03/29/16].
  18. Housden BE, Valvezan AJ, Kelley C, Sopko R, Hu Y, Roesel C, Lin S, Buckner M, Tao R, Yilmazel B, Mohr SE, Manning BD, Perrimon N. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Sci Signal. 2015 Sep 8; 8(393):rs9. PMID: 26350902; PMCID: PMC4642709 [Available on 03/08/16].
  19. Yan D, Perrimon N. spenito is required for sex determination in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11606-11. PMID: 26324914; PMCID: PMC4577178 [Available on 03/15/16].
  20. Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Wang X, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, Perrimon N. The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. Genetics. 2015 Nov; 201(3):843-52. PMID: 26320097; PMCID: PMC4649654 [Available on 11/01/16].
  21. Lin S, Ewen-Campen B, Ni X, Housden BE, Perrimon N. In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila. Genetics. 2015 Oct; 201(2):433-42. PMID: 26245833; PMCID: PMC4596659 [Available on 10/01/16].
  22. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. PMID: 26229113.
    View in: PubMed
  23. Mohr SE, Hu Y, Rudd K, Buckner M, Gilly Q, Foster B, Sierzputowska K, Comjean A, Ye B, Perrimon N. Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. G3 (Bethesda). 2015 Sep; 5(9):1919-24. PMID: 26199285; PMCID: PMC4555228.
  24. Hu Y, Comjean A, Perkins LA, Perrimon N, Mohr SE. GLAD: an Online Database of Gene List Annotation for Drosophila. J Genomics. 2015; 3:75-81. PMID: 26157507; PMCID: PMC4495321.
  25. Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, Van Vactor D. A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs. Nat Commun. 2015; 6:7279. PMID: 26081261; PMCID: PMC4471878.
  26. Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SC. Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Dev Cell. 2015 Jun 22; 33(6):729-36. PMID: 26051539; PMCID: PMC4481192 [Available on 06/22/16].
  27. Kwon Y, Song W, Droujinine IA, Hu Y, Asara JM, Perrimon N. Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2. Dev Cell. 2015 Apr 6; 33(1):36-46. PMID: 25850671; PMCID: PMC4437243 [Available on 04/06/16].
  28. Sopko R, Lin YB, Makhijani K, Alexander B, Perrimon N, Brückner K. A systems-level interrogation identifies regulators of Drosophila blood cell number and survival. PLoS Genet. 2015 Mar; 11(3):e1005056. PMID: 25749252; PMCID: PMC4352040.
  29. Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM. Highly efficient Cas9-mediated transcriptional programming. Nat Methods. 2015 Apr; 12(4):326-8. PMID: 25730490; PMCID: PMC4393883.
  30. Zirin J, Nieuwenhuis J, Samsonova A, Tao R, Perrimon N. Regulators of autophagosome formation in Drosophila muscles. PLoS Genet. 2015 Feb; 11(2):e1005006. PMID: 25692684; PMCID: PMC4334200.
  31. Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah K, Godes M, Perrimon N, Walensky LD. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1761-6. PMID: 25624485; PMCID: PMC4330742.
  32. Sopko R, Foos M, Vinayagam A, Zhai B, Binari R, Hu Y, Randklev S, Perkins LA, Gygi SP, Perrimon N. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Dev Cell. 2014 Oct 13; 31(1):114-27. PMID: 25284370; PMCID: PMC4208667.
  33. Droujinine IA, Yan D, Perrimon N. A sharp end to sugary Wingless travels. J Cell Biol. 2014 Sep 29; 206(7):819-21. PMID: 25267292; PMCID: PMC4178964.
  34. Song W, Veenstra JA, Perrimon N. Control of lipid metabolism by tachykinin in Drosophila. Cell Rep. 2014 Oct 9; 9(1):40-7. PMID: 25263556; PMCID: PMC4325997.
  35. Amcheslavsky A, Song W, Li Q, Nie Y, Bragatto I, Ferrandon D, Perrimon N, Ip YT. Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila. Cell Rep. 2014 Oct 9; 9(1):32-9. PMID: 25263551; PMCID: PMC4198943.
  36. Mohr SE, Smith JA, Shamu CE, Neumüller RA, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol. 2014 Sep; 15(9):591-600. PMID: 25145850; PMCID: PMC4204798.
  37. Gerstein MB, Rozowsky J, Yan KK, Wang D, Cheng C, Brown JB, Davis CA, Hillier L, Sisu C, Li JJ, Pei B, Harmanci AO, Duff MO, Djebali S, Alexander RP, Alver BH, Auerbach R, Bell K, Bickel PJ, Boeck ME, Boley NP, Booth BW, Cherbas L, Cherbas P, Di C, Dobin A, Drenkow J, Ewing B, Fang G, Fastuca M, Feingold EA, Frankish A, Gao G, Good PJ, Guigó R, Hammonds A, Harrow J, Hoskins RA, Howald C, Hu L, Huang H, Hubbard TJ, Huynh C, Jha S, Kasper D, Kato M, Kaufman TC, Kitchen RR, Ladewig E, Lagarde J, Lai E, Leng J, Lu Z, MacCoss M, May G, McWhirter R, Merrihew G, Miller DM, Mortazavi A, Murad R, Oliver B, Olson S, Park PJ, Pazin MJ, Perrimon N, Pervouchine D, Reinke V, Reymond A, Robinson G, Samsonova A, Saunders GI, Schlesinger F, Sethi A, Slack FJ, Spencer WC, Stoiber MH, Strasbourger P, Tanzer A, Thompson OA, Wan KH, Wang G, Wang H, Watkins KL, Wen J, Wen K, Xue C, Yang L, Yip K, Zaleski C, Zhang Y, Zheng H, Brenner SE, Graveley BR, Celniker SE, Gingeras TR, Waterston R. Comparative analysis of the transcriptome across distant species. Nature. 2014 Aug 28; 512(7515):445-8. PMID: 25164755; PMCID: PMC4155737.
  38. Brown JB, Boley N, Eisman R, May GE, Stoiber MH, Duff MO, Booth BW, Wen J, Park S, Suzuki AM, Wan KH, Yu C, Zhang D, Carlson JW, Cherbas L, Eads BD, Miller D, Mockaitis K, Roberts J, Davis CA, Frise E, Hammonds AS, Olson S, Shenker S, Sturgill D, Samsonova AA, Weiszmann R, Robinson G, Hernandez J, Andrews J, Bickel PJ, Carninci P, Cherbas P, Gingeras TR, Hoskins RA, Kaufman TC, Lai EC, Oliver B, Perrimon N, Graveley BR, Celniker SE. Diversity and dynamics of the Drosophila transcriptome. Nature. 2014 Aug 28; 512(7515):393-9. PMID: 24670639; PMCID: PMC4152413.
  39. Housden BE, Perrimon N. Spatial and temporal organization of signaling pathways. Trends Biochem Sci. 2014 Oct; 39(10):457-64. PMID: 25155749; PMCID: PMC4477539.
  40. Yilmazel B, Hu Y, Sigoillot F, Smith JA, Shamu CE, Perrimon N, Mohr SE. Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformatics. 2014; 15:192. PMID: 24934636; PMCID: PMC4073188.
  41. Perrimon N. Drosophila developmental biology methods. Methods. 2014 Jun 15; 68(1):1. PMID: 24908372.
    View in: PubMed
  42. Kim K, Vinayagam A, Perrimon N. A rapid genome-wide microRNA screen identifies miR-14 as a modulator of Hedgehog signaling. Cell Rep. 2014 Jun 26; 7(6):2066-77. PMID: 24931604; PMCID: PMC4142207.
  43. Demontis F, Patel VK, Swindell WR, Perrimon N. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Cell Rep. 2014 Jun 12; 7(5):1481-94. PMID: 24882005; PMCID: PMC4125979.
  44. Zhou R, Mohr S, Hannon GJ, Perrimon N. Inducing RNAi in Drosophila cells by soaking with dsRNA. Cold Spring Harb Protoc. 2014 May; 2014(5). PMID: 24786505; PMCID: PMC4465107.
  45. Doupé DP, Perrimon N. Visualizing and manipulating temporal signaling dynamics with fluorescence-based tools. Sci Signal. 2014 Apr 1; 7(319):re1. PMID: 24692594; PMCID: PMC4319366.
  46. Mohr SE, Hu Y, Kim K, Housden BE, Perrimon N. Resources for functional genomics studies in Drosophila melanogaster. Genetics. 2014 May; 197(1):1-18. PMID: 24653003; PMCID: PMC4012471.
  47. Griffin R, Binari R, Perrimon N. Genetic odyssey to generate marked clones in Drosophila mosaics. Proc Natl Acad Sci U S A. 2014 Apr 1; 111(13):4756-63. PMID: 24623854; PMCID: PMC3977257.
  48. Markstein M, Dettorre S, Cho J, Neumüller RA, Craig-Müller S, Perrimon N. Systematic screen of chemotherapeutics in Drosophila stem cell tumors. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4530-5. PMID: 24616500; PMCID: PMC3970492.
  49. Owusu-Ansah E, Perrimon N. Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases. Dis Model Mech. 2014 Mar; 7(3):343-50. PMID: 24609035; PMCID: PMC3944494.
  50. Yan D, Neumüller RA, Buckner M, Ayers K, Li H, Hu Y, Yang-Zhou D, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, Perrimon N. A regulatory network of Drosophila germline stem cell self-renewal. Dev Cell. 2014 Feb 24; 28(4):459-73. PMID: 24576427; PMCID: PMC3998650.
  51. Tipping M, Perrimon N. Drosophila as a model for context-dependent tumorigenesis. J Cell Physiol. 2014 Jan; 229(1):27-33. PMID: 23836429; PMCID: PMC4034382.
  52. Housden BE, Lin S, Perrimon N. Cas9-based genome editing in Drosophila. Methods Enzymol. 2014; 546:415-39. PMID: 25398351.
    View in: PubMed
  53. Droujinine IA, Perrimon N. Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress. Front Cell Infect Microbiol. 2013; 3:82. PMID: 24312902; PMCID: PMC3832798.
  54. Vinayagam A, Zirin J, Roesel C, Hu Y, Yilmazel B, Samsonova AA, Neumüller RA, Mohr SE, Perrimon N. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods. 2014 Jan; 11(1):94-9. PMID: 24240319; PMCID: PMC3877743.
  55. Zirin J, Nieuwenhuis J, Perrimon N. Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol. 2013 Nov; 11(11):e1001708. PMID: 24265594; PMCID: PMC3825659.
  56. Sun X, Hong P, Kulkarni M, Kwon Y, Perrimon N. PPIRank - an advanced method for ranking protein-protein interations in TAP/MS data. Proteome Sci. 2013 Nov 7; 11(Suppl 1):S16. PMID: 24565074; PMCID: PMC3908380.
  57. Ren X, Sun J, Housden BE, Hu Y, Roesel C, Lin S, Liu LP, Yang Z, Mao D, Sun L, Wu Q, Ji JY, Xi J, Mohr SE, Xu J, Perrimon N, Ni JQ. Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19012-7. PMID: 24191015; PMCID: PMC3839733.
  58. Owusu-Ansah E, Song W, Perrimon N. Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell. 2013 Oct 24; 155(3):699-712. PMID: 24243023; PMCID: PMC3856681.
  59. Piccirillo R, Demontis F, Perrimon N, Goldberg AL. Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn. 2014 Feb; 243(2):201-15. PMID: 24038488; PMCID: PMC3980484.
  60. Kwon Y, Vinayagam A, Sun X, Dephoure N, Gygi SP, Hong P, Perrimon N. The Hippo signaling pathway interactome. Science. 2013 Nov 8; 342(6159):737-40. PMID: 24114784; PMCID: PMC3951131.
  61. Demontis F, Piccirillo R, Goldberg AL, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013 Nov; 6(6):1339-52. PMID: 24092876; PMCID: PMC3820258.
  62. Xiong XP, Kurthkoti K, Chang KY, Lichinchi G, De N, Schneemann A, MacRae IJ, Rana TM, Perrimon N, Zhou R. Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A. 2013 Oct 8; 110(41):16520-5. PMID: 24067655; PMCID: PMC3799365.
  63. Shulman JM, Imboywa S, Giagtzoglou N, Powers MP, Hu Y, Devenport D, Chipendo P, Chibnik LB, Diamond A, Perrimon N, Brown NH, De Jager PL, Feany MB. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet. 2014 Feb 15; 23(4):870-7. PMID: 24067533; PMCID: PMC3900103.
  64. Zirin J, Cheng D, Dhanyasi N, Cho J, Dura JM, Vijayraghavan K, Perrimon N. Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles. Dev Biol. 2013 Nov 15; 383(2):275-84. PMID: 24051228; PMCID: PMC3991436.
  65. Hu Y, Sopko R, Foos M, Kelley C, Flockhart I, Ammeux N, Wang X, Perkins L, Perrimon N, Mohr SE. FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. G3 (Bethesda). 2013 Sep; 3(9):1607-16. PMID: 23893746; PMCID: PMC3755921.
  66. Neumüller RA, Gross T, Samsonova AA, Vinayagam A, Buckner M, Founk K, Hu Y, Sharifpoor S, Rosebrock AP, Andrews B, Winston F, Perrimon N. Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal. 2013 Aug 20; 6(289):ra70. PMID: 23962978; PMCID: PMC3964804.
  67. Demontis F, Piccirillo R, Goldberg AL, Perrimon N. The influence of skeletal muscle on systemic aging and lifespan. Aging Cell. 2013 Dec; 12(6):943-9. PMID: 23802635; PMCID: PMC3838468.
  68. Hu Y, Roesel C, Flockhart I, Perkins L, Perrimon N, Mohr SE. UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. Genetics. 2013 Sep; 195(1):37-45. PMID: 23792952; PMCID: PMC3761311.
  69. Yin Z, Sadok A, Sailem H, McCarthy A, Xia X, Li F, Garcia MA, Evans L, Barr AR, Perrimon N, Marshall CJ, Wong ST, Bakal C. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol. 2013 Jul; 15(7):860-71. PMID: 23748611; PMCID: PMC3712499.
  70. Silva-Ayala D, López T, Gutiérrez M, Perrimon N, López S, Arias CF. Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):10270-5. PMID: 23733942; PMCID: PMC3690850.
  71. Sopko R, Perrimon N. Receptor tyrosine kinases in Drosophila development. Cold Spring Harb Perspect Biol. 2013 Jun; 5(6). PMID: 23732470; PMCID: PMC3660834.
  72. Zhou R, Mohr S, Hannon GJ, Perrimon N. Inducing RNAi in Drosophila cells by transfection with dsRNA. Cold Spring Harb Protoc. 2013 May; 2013(5):461-3. PMID: 23637371.
    View in: PubMed
  73. Rajan A, Perrimon N. Of flies and men: insights on organismal metabolism from fruit flies. BMC Biol. 2013; 11:38. PMID: 23587196; PMCID: PMC3626883.
  74. Karpowicz P, Zhang Y, Hogenesch JB, Emery P, Perrimon N. The circadian clock gates the intestinal stem cell regenerative state. Cell Rep. 2013 Apr 25; 3(4):996-1004. PMID: 23583176; PMCID: PMC3982394.
  75. Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. Genetic determinants of phosphate response in Drosophila. PLoS One. 2013; 8(3):e56753. PMID: 23520455; PMCID: PMC3592877.
  76. Vinayagam A, Hu Y, Kulkarni M, Roesel C, Sopko R, Mohr SE, Perrimon N. Protein complex-based analysis framework for high-throughput data sets. Sci Signal. 2013 Feb 26; 6(264):rs5. PMID: 23443684; PMCID: PMC3756668.
  77. Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 2013 Mar 18; 23(3):390-405. PMID: 23434461; PMCID: PMC3709972.
  78. Pitsouli C, Perrimon N. The homeobox transcription factor cut coordinates patterning and growth during Drosophila airway remodeling. Sci Signal. 2013 Feb 19; 6(263):ra12. PMID: 23423438; PMCID: PMC3982146.
  79. Yeh JT, Binari R, Gocha T, Dasgupta R, Perrimon N. PAPTi: a peptide aptamer interference toolkit for perturbation of protein-protein interaction networks. Sci Rep. 2013; 3:1156. PMID: 23362456; PMCID: PMC3557448.
  80. Staller MV, Yan D, Randklev S, Bragdon MD, Wunderlich ZB, Tao R, Perkins LA, Depace AH, Perrimon N. Depleting gene activities in early Drosophila embryos with the "maternal-Gal4-shRNA" system. Genetics. 2013 Jan; 193(1):51-61. PMID: 23105012; PMCID: PMC3527254.
  81. Rajan A, Perrimon N. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell. 2012 Sep 28; 151(1):123-37. PMID: 23021220; PMCID: PMC3475207.
  82. Hosur R, Peng J, Vinayagam A, Stelzl U, Xu J, Perrimon N, Bienkowska J, Berger B. A computational framework for boosting confidence in high-throughput protein-protein interaction datasets. Genome Biol. 2012; 13(8):R76. PMID: 22937800; PMCID: PMC4053744.
  83. Stender JD, Pascual G, Liu W, Kaikkonen MU, Do K, Spann NJ, Boutros M, Perrimon N, Rosenfeld MG, Glass CK. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell. 2012 Oct 12; 48(1):28-38. PMID: 22921934; PMCID: PMC3472359.
  84. Perrimon N, Pitsouli C, Shilo BZ. Signaling mechanisms controlling cell fate and embryonic patterning. Cold Spring Harb Perspect Biol. 2012 Aug; 4(8):a005975. PMID: 22855721; PMCID: PMC3405863.
  85. Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 2012 Jul 3; 16(1):97-103. PMID: 22768842; PMCID: PMC3400463.
  86. Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development. 2012 Aug; 139(15):2821-31. PMID: 22745315; PMCID: PMC3392707.
  87. Kusche-Gullberg M, Nybakken K, Perrimon N, Lindahl U. Drosophila heparan sulfate, a novel design. J Biol Chem. 2012 Jun 22; 287(26):21950-6. PMID: 22556423; PMCID: PMC3381155.
  88. Bergwitz C, Rasmussen MD, DeRobertis C, Wee MJ, Sinha S, Chen HH, Huang J, Perrimon N. Roles of major facilitator superfamily transporters in phosphate response in Drosophila. PLoS One. 2012; 7(2):e31730. PMID: 22359624; PMCID: PMC3280997.
  89. Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N. Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics. 2012 Mar; 190(3):931-40. PMID: 22174071; PMCID: PMC3296255.
  90. Perrimon N, Barkai N. The era of systems developmental biology. Curr Opin Genet Dev. 2011 Dec; 21(6):681-3. PMID: 22079435.
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  91. Flockhart IT, Booker M, Hu Y, McElvany B, Gilly Q, Mathey-Prevot B, Perrimon N, Mohr SE. FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. Nucleic Acids Res. 2012 Jan; 40(Database issue):D715-9. PMID: 22067456; PMCID: PMC3245182.
  92. Friedman AA, Tucker G, Singh R, Yan D, Vinayagam A, Hu Y, Binari R, Hong P, Sun X, Porto M, Pacifico S, Murali T, Finley RL, Asara JM, Berger B, Perrimon N. Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Sci Signal. 2011; 4(196):rs10. PMID: 22028469; PMCID: PMC3439136.
  93. Mohr SE, Perrimon N. RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip Rev RNA. 2012 Mar-Apr; 3(2):145-58. PMID: 21953743; PMCID: PMC3249004.
  94. Rohn JL, Sims D, Liu T, Fedorova M, Schöck F, Dopie J, Vartiainen MK, Kiger AA, Perrimon N, Baum B. Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol. 2011 Sep 5; 194(5):789-805. PMID: 21893601; PMCID: PMC3171124.
  95. Hu Y, Flockhart I, Vinayagam A, Bergwitz C, Berger B, Perrimon N, Mohr SE. An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics. 2011; 12:357. PMID: 21880147; PMCID: PMC3179972.
  96. Rajan A, Perrimon N. Drosophila as a model for interorgan communication: lessons from studies on energy homeostasis. Dev Cell. 2011 Jul 19; 21(1):29-31. PMID: 21763605; PMCID: PMC3560414.
  97. Schnall-Levin M, Rissland OS, Johnston WK, Perrimon N, Bartel DP, Berger B. Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. Genome Res. 2011 Sep; 21(9):1395-403. PMID: 21685129; PMCID: PMC3166825.
  98. Ni JQ, Zhou R, Czech B, Liu LP, Holderbaum L, Yang-Zhou D, Shim HS, Tao R, Handler D, Karpowicz P, Binari R, Booker M, Brennecke J, Perkins LA, Hannon GJ, Perrimon N. A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods. 2011 May; 8(5):405-7. PMID: 21460824; PMCID: PMC3489273.
  99. Perrimon N, Zirin J, Bai J. Primary cell cultures from Drosophila gastrula embryos. J Vis Exp. 2011; (48). PMID: 21403631; PMCID: PMC3197384.
  100. Chan WM, Tsoi H, Wu CC, Wong CH, Cheng TC, Li HY, Lau KF, Shaw PC, Perrimon N, Chan HY. Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Hum Mol Genet. 2011 May 1; 20(9):1738-50. PMID: 21300695.
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  101. Gibson WT, Veldhuis JH, Rubinstein B, Cartwright HN, Perrimon N, Brodland GW, Nagpal R, Gibson MC. Control of the mitotic cleavage plane by local epithelial topology. Cell. 2011 Feb 4; 144(3):427-38. PMID: 21295702; PMCID: PMC3491649.
  102. Booker M, Samsonova AA, Kwon Y, Flockhart I, Mohr SE, Perrimon N. False negative rates in Drosophila cell-based RNAi screens: a case study. BMC Genomics. 2011; 12:50. PMID: 21251254; PMCID: PMC3036618.
  103. Kondo S, Perrimon N. A genome-wide RNAi screen identifies core components of the G2-M DNA damage checkpoint. Sci Signal. 2011; 4(154):rs1. PMID: 21205937; PMCID: PMC3489265.
  104. Neumüller RA, Perrimon N. Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila. Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug; 3(4):471-8. PMID: 21197652; PMCID: PMC3560415.
  105. Berezikov E, Robine N, Samsonova A, Westholm JO, Naqvi A, Hung JH, Okamura K, Dai Q, Bortolamiol-Becet D, Martin R, Zhao Y, Zamore PD, Hannon GJ, Marra MA, Weng Z, Perrimon N, Lai EC. Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res. 2011 Feb; 21(2):203-15. PMID: 21177969; PMCID: PMC3032924.
  106. Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, Robine N, Washington NL, Di Stefano L, Berezikov E, Brown CD, Candeias R, Carlson JW, Carr A, Jungreis I, Marbach D, Sealfon R, Tolstorukov MY, Will S, Alekseyenko AA, Artieri C, Booth BW, Brooks AN, Dai Q, Davis CA, Duff MO, Feng X, Gorchakov AA, Gu T, Henikoff JG, Kapranov P, Li R, MacAlpine HK, Malone J, Minoda A, Nordman J, Okamura K, Perry M, Powell SK, Riddle NC, Sakai A, Samsonova A, Sandler JE, Schwartz YB, Sher N, Spokony R, Sturgill D, van Baren M, Wan KH, Yang L, Yu C, Feingold E, Good P, Guyer M, Lowdon R, Ahmad K, Andrews J, Berger B, Brenner SE, Brent MR, Cherbas L, Elgin SC, Gingeras TR, Grossman R, Hoskins RA, Kaufman TC, Kent W, Kuroda MI, Orr-Weaver T, Perrimon N, Pirrotta V, Posakony JW, Ren B, Russell S, Cherbas P, Graveley BR, Lewis S, Micklem G, Oliver B, Park PJ, Celniker SE, Henikoff S, Karpen GH, Lai EC, MacAlpine DM, Stein LD, White KP, Kellis M. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science. 2010 Dec 24; 330(6012):1787-97. PMID: 21177974; PMCID: PMC3192495.
  107. Graveley BR, Brooks AN, Carlson JW, Duff MO, Landolin JM, Yang L, Artieri CG, van Baren MJ, Boley N, Booth BW, Brown JB, Cherbas L, Davis CA, Dobin A, Li R, Lin W, Malone JH, Mattiuzzo NR, Miller D, Sturgill D, Tuch BB, Zaleski C, Zhang D, Blanchette M, Dudoit S, Eads B, Green RE, Hammonds A, Jiang L, Kapranov P, Langton L, Perrimon N, Sandler JE, Wan KH, Willingham A, Zhang Y, Zou Y, Andrews J, Bickel PJ, Brenner SE, Brent MR, Cherbas P, Gingeras TR, Hoskins RA, Kaufman TC, Oliver B, Celniker SE. The developmental transcriptome of Drosophila melanogaster. Nature. 2011 Mar 24; 471(7339):473-9. PMID: 21179090; PMCID: PMC3075879.
  108. Cherbas L, Willingham A, Zhang D, Yang L, Zou Y, Eads BD, Carlson JW, Landolin JM, Kapranov P, Dumais J, Samsonova A, Choi JH, Roberts J, Davis CA, Tang H, van Baren MJ, Ghosh S, Dobin A, Bell K, Lin W, Langton L, Duff MO, Tenney AE, Zaleski C, Brent MR, Hoskins RA, Kaufman TC, Andrews J, Graveley BR, Perrimon N, Celniker SE, Gingeras TR, Cherbas P. The transcriptional diversity of 25 Drosophila cell lines. Genome Res. 2011 Feb; 21(2):301-14. PMID: 21177962; PMCID: PMC3032933.
  109. Karpowicz P, Perez J, Perrimon N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development. 2010 Dec; 137(24):4135-45. PMID: 21098564; PMCID: PMC2990205.
  110. Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell. 2010 Nov 24; 143(5):813-25. PMID: 21111239; PMCID: PMC3066043.
  111. Rui Y, Bai J, Perrimon N. Sarcomere formation occurs by the assembly of multiple latent protein complexes. PLoS Genet. 2010 Nov; 6(11):e1001208. PMID: 21124995; PMCID: PMC2987826.
  112. Pitsouli C, Perrimon N. Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis. Development. 2010 Nov; 137(21):3615-24. PMID: 20940225; PMCID: PMC2964094.
  113. Karpowicz P, Perrimon N. All for one, and one for all: the clonality of the intestinal stem cell niche. F1000 Biol Rep. 2010; 2:73. PMID: 21173846; PMCID: PMC2989629.
  114. Micchelli CA, Sudmeier L, Perrimon N, Tang S, Beehler-Evans R. Identification of adult midgut precursors in Drosophila. Gene Expr Patterns. 2011 Jan-Feb; 11(1-2):12-21. PMID: 20804858.
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  115. Zirin J, Perrimon N. Drosophila as a model system to study autophagy. Semin Immunopathol. 2010 Dec; 32(4):363-72. PMID: 20798940; PMCID: PMC3562086.
  116. Schnall-Levin M, Zhao Y, Perrimon N, Berger B. Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A. 2010 Sep 7; 107(36):15751-6. PMID: 20729470; PMCID: PMC2936641.
  117. Yan H, Venkatesan K, Beaver JE, Klitgord N, Yildirim MA, Hao T, Hill DE, Cusick ME, Perrimon N, Roth FP, Vidal M. A genome-wide gene function prediction resource for Drosophila melanogaster. PLoS One. 2010; 5(8):e12139. PMID: 20711346; PMCID: PMC2920829.
  118. Rajan A, Perrimon N. Steroids make you bigger? Fat chance says Myc. Cell Metab. 2010 Jul 7; 12(1):7-9. PMID: 20620990.
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  119. Kockel L, Kerr KS, Melnick M, Brückner K, Hebrok M, Perrimon N. Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet. 2010 Jun; 6(6):e1000990. PMID: 20585550; PMCID: PMC2887466.
  120. Perrimon N, Ni JQ, Perkins L. In vivo RNAi: today and tomorrow. Cold Spring Harb Perspect Biol. 2010 Aug; 2(8):a003640. PMID: 20534712; PMCID: PMC2908776.
  121. Bakal C, Perrimon N. Realizing the promise of RNAi high throughput screening. Dev Cell. 2010 Apr 20; 18(4):506-7. PMID: 20412765; PMCID: PMC2868582.
  122. Nir O, Bakal C, Perrimon N, Berger B. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Genome Res. 2010 Mar; 20(3):372-80. PMID: 20144944; PMCID: PMC2840989.
  123. Zhang S, Binari R, Zhou R, Perrimon N. A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics. 2010 Apr; 184(4):1165-79. PMID: 20100940; PMCID: PMC2865916.
  124. Mohr S, Bakal C, Perrimon N. Genomic screening with RNAi: results and challenges. Annu Rev Biochem. 2010; 79:37-64. PMID: 20367032; PMCID: PMC3564595.
  125. Yang X, Friedman A, Nagpal S, Perrimon N, Asara JM. Use of a label-free quantitative platform based on MS/MS average TIC to calculate dynamics of protein complexes in insulin signaling. J Biomol Tech. 2009 Dec; 20(5):272-7. PMID: 19949701; PMCID: PMC2777340.
  126. Apidianakis Y, Pitsouli C, Perrimon N, Rahme L. Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A. 2009 Dec 8; 106(49):20883-8. PMID: 19934041.
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  127. Czech B, Zhou R, Erlich Y, Brennecke J, Binari R, Villalta C, Gordon A, Perrimon N, Hannon GJ. Hierarchical rules for Argonaute loading in Drosophila. Mol Cell. 2009 Nov 13; 36(3):445-56. PMID: 19917252; PMCID: PMC2795325.
  128. Pitsouli C, Apidianakis Y, Perrimon N. Homeostasis in infected epithelia: stem cells take the lead. Cell Host Microbe. 2009 Oct 22; 6(4):301-7. PMID: 19837370.
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  129. Bai J, Sepp KJ, Perrimon N. Culture of Drosophila primary cells dissociated from gastrula embryos and their use in RNAi screening. Nat Protoc. 2009; 4(10):1502-12. PMID: 19798083.
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  130. Kondo S, Booker M, Perrimon N. Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics. 2009 Nov; 183(3):1165-73. PMID: 19720858; PMCID: PMC2778968.
  131. Vinegoni C, Razansky D, Pitsouli C, Perrimon N, Ntziachristos V, Weissleder R. Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila. J Vis Exp. 2009; (30). PMID: 19696720; PMCID: PMC2736679.
  132. Zhou R, Czech B, Brennecke J, Sachidanandam R, Wohlschlegel JA, Perrimon N, Hannon GJ. Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA. 2009 Oct; 15(10):1886-95. PMID: 19635780; PMCID: PMC2743050.
  133. Griffin R, Sustar A, Bonvin M, Binari R, del Valle Rodriguez A, Hohl AM, Bateman JR, Villalta C, Heffern E, Grunwald D, Bakal C, Desplan C, Schubiger G, Wu CT, Perrimon N. The twin spot generator for differential Drosophila lineage analysis. Nat Methods. 2009 Aug; 6(8):600-2. PMID: 19633664; PMCID: PMC2720837.
  134. Brouzes E, Medkova M, Savenelli N, Marran D, Twardowski M, Hutchison JB, Rothberg JM, Link DR, Perrimon N, Samuels ML. Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14195-200. PMID: 19617544; PMCID: PMC2732882.
  135. Kaplow IM, Singh R, Friedman A, Bakal C, Perrimon N, Berger B. RNAiCut: automated detection of significant genes from functional genomic screens. Nat Methods. 2009 Jul; 6(7):476-7. PMID: 19564846.
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  136. Ni JQ, Liu LP, Binari R, Hardy R, Shim HS, Cavallaro A, Booker M, Pfeiffer BD, Markstein M, Wang H, Villalta C, Laverty TR, Perkins LA, Perrimon N. A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics. 2009 Aug; 182(4):1089-100. PMID: 19487563; PMCID: PMC2728850.
  137. Zhang S, Feany MB, Saraswati S, Littleton JT, Perrimon N. Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Dis Model Mech. 2009 May-Jun; 2(5-6):247-66. PMID: 19380309; PMCID: PMC2675792.
  138. Demontis F, Perrimon N. Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development. 2009 Mar; 136(6):983-93. PMID: 19211682; PMCID: PMC2727562.
  139. Zhou R, Hotta I, Denli AM, Hong P, Perrimon N, Hannon GJ. Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Mol Cell. 2008 Nov 21; 32(4):592-9. PMID: 19026789; PMCID: PMC2615197.
  140. Bakal C, Linding R, Llense F, Heffern E, Martin-Blanco E, Pawson T, Perrimon N. Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science. 2008 Oct 17; 322(5900):453-6. PMID: 18927396; PMCID: PMC2581798.
  141. Pitsouli C, Perrimon N. Developmental biology: Our fly cousins' gut. Nature. 2008 Jul 31; 454(7204):592-3. PMID: 18668098.
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  142. Vincent S, Perrimon N, Axelrod JD. Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development. 2008 Aug; 135(16):2767-75. PMID: 18614578; PMCID: PMC2585068.
  143. Sepp KJ, Hong P, Lizarraga SB, Liu JS, Mejia LA, Walsh CA, Perrimon N. Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet. 2008 Jul; 4(7):e1000111. PMID: 18604272; PMCID: PMC2435276.
  144. Yin Z, Zhou X, Bakal C, Li F, Sun Y, Perrimon N, Wong ST. Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC Bioinformatics. 2008; 9:264. PMID: 18534020; PMCID: PMC2443381.
  145. Czech B, Malone CD, Zhou R, Stark A, Schlingeheyde C, Dus M, Perrimon N, Kellis M, Wohlschlegel JA, Sachidanandam R, Hannon GJ, Brennecke J. An endogenous small interfering RNA pathway in Drosophila. Nature. 2008 Jun 5; 453(7196):798-802. PMID: 18463631; PMCID: PMC2895258.
  146. Wang J, Zhou X, Li F, Bradley PL, Chang SF, Perrimon N, Wong ST. An image score inference system for RNAi genome-wide screening based on fuzzy mixture regression modeling. J Biomed Inform. 2009 Feb; 42(1):32-40. PMID: 18547870; PMCID: PMC2763194.
  147. Bai J, Binari R, Ni JQ, Vijayakanthan M, Li HS, Perrimon N. RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance. Development. 2008 Apr; 135(8):1439-49. PMID: 18359903.
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  148. Markstein M, Pitsouli C, Villalta C, Celniker SE, Perrimon N. Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet. 2008 Apr; 40(4):476-83. PMID: 18311141; PMCID: PMC2330261.
  149. Philips JA, Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3070-5. PMID: 18287038; PMCID: PMC2268586.
  150. Wang J, Zhou X, Bradley PL, Chang SF, Perrimon N, Wong ST. Cellular phenotype recognition for high-content RNA interference genome-wide screening. J Biomol Screen. 2008 Jan; 13(1):29-39. PMID: 18227224.
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  151. Ni JQ, Markstein M, Binari R, Pfeiffer B, Liu LP, Villalta C, Booker M, Perkins L, Perrimon N. Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods. 2008 Jan; 5(1):49-51. PMID: 18084299; PMCID: PMC2290002.
  152. Vinegoni C, Pitsouli C, Razansky D, Perrimon N, Ntziachristos V. In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography. Nat Methods. 2008 Jan; 5(1):45-7. PMID: 18066071.
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  153. Bai J, Hartwig JH, Perrimon N. SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007 Dec; 13(6):828-42. PMID: 18061565.
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  154. Leopold P, Perrimon N. Drosophila and the genetics of the internal milieu. Nature. 2007 Nov 8; 450(7167):186-8. PMID: 17994083.
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  155. Silver SJ, Hagen JW, Okamura K, Perrimon N, Lai EC. Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18151-6. PMID: 17989227; PMCID: PMC2084312.
  156. Bakal C, Aach J, Church G, Perrimon N. Quantitative morphological signatures define local signaling networks regulating cell morphology. Science. 2007 Jun 22; 316(5832):1753-6. PMID: 17588932.
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  157. Lu J, Ruhf ML, Perrimon N, Leder P. A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9381-6. PMID: 17517653; PMCID: PMC1890503.
  158. Mathey-Prevot B, Perrimon N. Do-it-yourself RNAi made easy? Nat Methods. 2007 Apr; 4(4):308-9. PMID: 17396126.
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  159. Friedman A, Perrimon N. Genetic screening for signal transduction in the era of network biology. Cell. 2007 Jan 26; 128(2):225-31. PMID: 17254958.
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  160. Perrimon N, Mathey-Prevot B. Matter arising: off-targets and genome-scale RNAi screens in Drosophila. Fly (Austin). 2007 Jan-Feb; 1(1):1-5. PMID: 18705022.
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  161. DasGupta R, Nybakken K, Booker M, Mathey-Prevot B, Gonsalves F, Changkakoty B, Perrimon N. A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila. Genome Biol. 2007; 8(9):R203. PMID: 17903264; PMCID: PMC2375041.
  162. Ramadan N, Flockhart I, Booker M, Perrimon N, Mathey-Prevot B. Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc. 2007; 2(9):2245-64. PMID: 17853882.
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  163. Perrimon N, Mathey-Prevot B. Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics. 2007 Jan; 175(1):7-16. PMID: 17244760; PMCID: PMC1775003.
  164. Friedman A, Perrimon N. High-throughput approaches to dissecting MAPK signaling pathways. Methods. 2006 Nov; 40(3):262-71. PMID: 16844385.
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  165. Friedman A, Perrimon N. A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature. 2006 Nov 9; 444(7116):230-4. PMID: 17086199.
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  166. Perrimon N, Friedman A, Mathey-Prevot B, Eggert US. Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. Drug Discov Today. 2007 Jan; 12(1-2):28-33. PMID: 17198970.
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  167. Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prévôt B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods. 2006 Oct; 3(10):777-9. PMID: 16990807.
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  168. Cherry S, Kunte A, Wang H, Coyne C, Rawson RB, Perrimon N. COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog. 2006 Oct; 2(10):e102. PMID: 17040126; PMCID: PMC1599761.
  169. Kulkarni MM, Booker M, Silver SJ, Friedman A, Hong P, Perrimon N, Mathey-Prevot B. Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods. 2006 Oct; 3(10):833-8. PMID: 16964256.
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  170. Bach EA, Ekas LA, Ayala-Camargo A, Flaherty MS, Lee H, Perrimon N, Baeg GH. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns. 2007 Jan; 7(3):323-31. PMID: 17008134.
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  171. Gibson MC, Patel AB, Nagpal R, Perrimon N. The emergence of geometric order in proliferating metazoan epithelia. Nature. 2006 Aug 31; 442(7106):1038-41. PMID: 16900102.
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  172. Chen LY, Wang JC, Hyvert Y, Lin HP, Perrimon N, Imler JL, Hsu JC. Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Curr Biol. 2006 Jun 20; 16(12):1183-93. PMID: 16782008.
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  173. Echeverri CJ, Perrimon N. High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet. 2006 May; 7(5):373-84. PMID: 16607398.
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  174. Bard F, Casano L, Mallabiabarrena A, Wallace E, Saito K, Kitayama H, Guizzunti G, Hu Y, Wendler F, Dasgupta R, Perrimon N, Malhotra V. Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature. 2006 Feb 2; 439(7076):604-7. PMID: 16452979.
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  175. Mathey-Prevot B, Perrimon N. Drosophila genome-wide RNAi screens: are they delivering the promise? Cold Spring Harb Symp Quant Biol. 2006; 71:141-8. PMID: 17381290.
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  176. Flockhart I, Booker M, Kiger A, Boutros M, Armknecht S, Ramadan N, Richardson K, Xu A, Perrimon N, Mathey-Prevot B. FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res. 2006 Jan 1; 34(Database issue):D489-94. PMID: 16381918; PMCID: PMC1347476.
  177. Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature. 2006 Jan 26; 439(7075):475-9. PMID: 16340959.
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  178. Nybakken K, Vokes SA, Lin TY, McMahon AP, Perrimon N. A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet. 2005 Dec; 37(12):1323-32. PMID: 16311596.
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  179. Kirilly D, Spana EP, Perrimon N, Padgett RW, Xie T. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell. 2005 Nov; 9(5):651-62. PMID: 16256740.
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  180. Karsten P, Plischke I, Perrimon N, Zeidler MP. Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E. Cell Signal. 2006 Jun; 18(6):819-29. PMID: 16129580.
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  181. Schober M, Rebay I, Perrimon N. Function of the ETS transcription factor Yan in border cell migration. Development. 2005 Aug; 132(15):3493-504. PMID: 16014514.
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  182. Baeg GH, Zhou R, Perrimon N. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev. 2005 Aug 15; 19(16):1861-70. PMID: 16055650; PMCID: PMC1186186.
  183. Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science. 2005 Aug 19; 309(5738):1248-51. PMID: 16020693.
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  184. Philips JA, Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science. 2005 Aug 19; 309(5738):1251-3. PMID: 16020694.
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  185. Perrimon N. Norbert Perrimon. Curr Biol. 2005 Jul 12; 15(13):R481-2. PMID: 16059997.
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  186. Häcker U, Nybakken K, Perrimon N. Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol. 2005 Jul; 6(7):530-41. PMID: 16072037.
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  187. DasGupta R, Boutros M, Perrimon N. Drosophila Wnt/Fz pathways. Sci STKE. 2005 May 10; 2005(283):cm5. PMID: 15886387.
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  188. Kulkarni MM, Perrimon N. Super-size flies. Cell Metab. 2005 May; 1(5):288-90. PMID: 16054074.
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  189. DasGupta R, Kaykas A, Moon RT, Perrimon N. Functional genomic analysis of the Wnt-wingless signaling pathway. Science. 2005 May 6; 308(5723):826-33. PMID: 15817814.
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  190. Gibson MC, Perrimon N. Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science. 2005 Mar 18; 307(5716):1785-9. PMID: 15774762.
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  191. Hayward P, Brennan K, Sanders P, Balayo T, DasGupta R, Perrimon N, Martinez Arias A. Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development. 2005 Apr; 132(8):1819-30. PMID: 15772135; PMCID: PMC2500123.
  192. Cherry S, Doukas T, Armknecht S, Whelan S, Wang H, Sarnow P, Perrimon N. Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev. 2005 Feb 15; 19(4):445-52. PMID: 15713840; PMCID: PMC548945.
  193. Zhou X, Liu KY, Bradley P, Perrimon N, Wong ST. Towards automated cellular image segmentation for RNAi genome-wide screening. Med Image Comput Comput Assist Interv. 2005; 8(Pt 1):885-92. PMID: 16685930.
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  194. Armknecht S, Boutros M, Kiger A, Nybakken K, Mathey-Prevot B, Perrimon N. High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol. 2005; 392:55-73. PMID: 15644175.
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  195. Baeg GH, Selva EM, Goodman RM, Dasgupta R, Perrimon N. The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors. Dev Biol. 2004 Dec 1; 276(1):89-100. PMID: 15531366.
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  196. Dasgupta R, Perrimon N. Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research. Oncogene. 2004 Nov 1; 23(51):8359-65. PMID: 15517017.
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  197. Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004 Dec; 2(12):e379. PMID: 15547975; PMCID: PMC528723.
  198. Friedman A, Perrimon N. Genome-wide high-throughput screens in functional genomics. Curr Opin Genet Dev. 2004 Oct; 14(5):470-6. PMID: 15380236.
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  199. Schlesinger A, Kiger A, Perrimon N, Shilo BZ. Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila. Dev Cell. 2004 Oct; 7(4):535-45. PMID: 15469842.
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  200. Sinenko SA, Kim EK, Wynn R, Manfruelli P, Ando I, Wharton KA, Perrimon N, Mathey-Prevot B. Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. Dev Biol. 2004 Sep 1; 273(1):48-62. PMID: 15302597.
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  201. Brückner K, Kockel L, Duchek P, Luque CM, Rørth P, Perrimon N. The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell. 2004 Jul; 7(1):73-84. PMID: 15239955.
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  202. Zeidler MP, Tan C, Bellaiche Y, Cherry S, Häder S, Gayko U, Perrimon N. Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol. 2004 Jul; 22(7):871-6. PMID: 15184905.
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  203. Perrimon N, Häcker U. Wingless, hedgehog and heparan sulfate proteoglycans. Development. 2004 Jun; 131(11):2509-11; author reply 2511-3. PMID: 15148297.
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  204. Agaisse H, Perrimon N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev. 2004 Apr; 198:72-82. PMID: 15199955.
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  205. Boutros M, Kiger AA, Armknecht S, Kerr K, Hild M, Koch B, Haas SA, Paro R, Perrimon N. Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science. 2004 Feb 6; 303(5659):832-5. PMID: 14764878.
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  206. Cherry S, Perrimon N. Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol. 2004 Jan; 5(1):81-7. PMID: 14691479.
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  207. Gibson MC, Perrimon N. Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol. 2003 Dec; 15(6):747-52. PMID: 14644201.
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  208. Bach EA, Vincent S, Zeidler MP, Perrimon N. A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics. 2003 Nov; 165(3):1149-66. PMID: 14668372; PMCID: PMC1462825.
  209. Kiger AA, Baum B, Jones S, Jones MR, Coulson A, Echeverri C, Perrimon N. A functional genomic analysis of cell morphology using RNA interference. J Biol. 2003; 2(4):27. PMID: 14527345; PMCID: PMC333409.
  210. Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell. 2003 Sep; 5(3):441-50. PMID: 12967563.
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  211. Ghiglione C, Amundadottir L, Andresdottir M, Bilder D, Diamonti JA, Noselli S, Perrimon N, Carraway III KL. Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development. 2003 Sep; 130(18):4483-93. PMID: 12900463.
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  212. Sasamura T, Sasaki N, Miyashita F, Nakao S, Ishikawa HO, Ito M, Kitagawa M, Harigaya K, Spana E, Bilder D, Perrimon N, Matsuno K. neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development. 2003 Oct; 130(20):4785-95. PMID: 12917292.
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  213. Lüders F, Segawa H, Stein D, Selva EM, Perrimon N, Turco SJ, Häcker U. Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila. EMBO J. 2003 Jul 15; 22(14):3635-44. PMID: 12853478; PMCID: PMC165615.
  214. Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003 Jul 1; 259(1):1-8. PMID: 12812783.
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  215. Adám G, Perrimon N, Noselli S. The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila. Development. 2003 Jun; 130(11):2397-406. PMID: 12702654.
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  216. Nagy A, Perrimon N, Sandmeyer S, Plasterk R. Tailoring the genome: the power of genetic approaches. Nat Genet. 2003 Mar; 33 Suppl:276-84. PMID: 12610537.
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  217. Schöck F, Perrimon N. Retraction of the Drosophila germ band requires cell-matrix interaction. Genes Dev. 2003 Mar 1; 17(5):597-602. PMID: 12629042; PMCID: PMC196012.
  218. Tan C, Stronach B, Perrimon N. Roles of myosin phosphatase during Drosophila development. Development. 2003 Feb; 130(4):671-81. PMID: 12505998.
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  219. Bilder D, Schober M, Perrimon N. Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol. 2003 Jan; 5(1):53-8. PMID: 12510194.
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  220. Nybakken K, Perrimon N. Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila. Biochim Biophys Acta. 2002 Dec 19; 1573(3):280-91. PMID: 12417410.
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  221. Song HJ, Billeter JC, Reynaud E, Carlo T, Spana EP, Perrimon N, Goodwin SF, Baker BS, Taylor BJ. The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics. 2002 Dec; 162(4):1703-24. PMID: 12524343; PMCID: PMC1462372.
  222. Hou SX, Zheng Z, Chen X, Perrimon N. The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev Cell. 2002 Dec; 3(6):765-78. PMID: 12479803.
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  223. Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, Van Vactor D. A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron. 2002 Nov 14; 36(4):611-22. PMID: 12441051.
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  224. Boutros M, Agaisse H, Perrimon N. Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell. 2002 Nov; 3(5):711-22. PMID: 12431377.
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  225. Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003 Jan; 17(1):79-81. PMID: 12424225.
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  226. Nybakken K, Perrimon N. Hedgehog signal transduction: recent findings. Curr Opin Genet Dev. 2002 Oct; 12(5):503-11. PMID: 12200154.
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  227. Li WX, Agaisse H, Mathey-Prevot B, Perrimon N. Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. Development. 2002 Sep; 129(18):4241-8. PMID: 12183376; PMCID: PMC3090254.
  228. Schober M, Perrimon N. Unconventional ways to travel. Nat Cell Biol. 2002 Sep; 4(9):E211-2. PMID: 12205482.
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  229. Hrdlicka L, Gibson M, Kiger A, Micchelli C, Schober M, Schöck F, Perrimon N. Analysis of twenty-four Gal4 lines in Drosophila melanogaster. Genesis. 2002 Sep-Oct; 34(1-2):51-7. PMID: 12324947.
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  230. Schöck F, Perrimon N. Cellular processes associated with germ band retraction in Drosophila. Dev Biol. 2002 Aug 1; 248(1):29-39. PMID: 12142018.
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  231. Moon RT, Bowerman B, Boutros M, Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science. 2002 May 31; 296(5573):1644-6. PMID: 12040179.
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  232. Lin X, Perrimon N. Developmental roles of heparan sulfate proteoglycans in Drosophila. Glycoconj J. 2002 May-Jun; 19(4-5):363-8. PMID: 12975617.
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  233. Schock F, Perrimon N. Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol. 2002; 18:463-93. PMID: 12142280.
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  234. Mathew D, Gramates LS, Packard M, Thomas U, Bilder D, Perrimon N, Gorczyca M, Budnik V. Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr Biol. 2002 Apr 2; 12(7):531-9. PMID: 11937021.
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  235. Chen HW, Marinissen MJ, Oh SW, Chen X, Melnick M, Perrimon N, Gutkind JS, Hou SX. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol. 2002 Mar; 22(6):1792-803. PMID: 11865058; PMCID: PMC135602.
  236. Stronach B, Perrimon N. Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 2002 Feb 1; 16(3):377-87. PMID: 11825878; PMCID: PMC155330.
  237. Micchelli CA, The I, Selva E, Mogila V, Perrimon N. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development. 2002 Feb; 129(4):843-51. PMID: 11861468.
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  238. Ghiglione C, Bach EA, Paraiso Y, Carraway KL, Noselli S, Perrimon N. Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development. 2002 Jan; 129(1):175-86. PMID: 11782411.
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  239. Hong Y, Stronach B, Perrimon N, Jan LY, Jan YN. Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature. 2001 Dec 6; 414(6864):634-8. PMID: 11740559.
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  240. Baum B, Perrimon N. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat Cell Biol. 2001 Oct; 3(10):883-90. PMID: 11584269.
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  241. Suzanne M, Perrimon N, Noselli S. The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev Biol. 2001 Sep 15; 237(2):282-94. PMID: 11543614.
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  242. Selva EM, Hong K, Baeg GH, Beverley SM, Turco SJ, Perrimon N, Häcker U. Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nat Cell Biol. 2001 Sep; 3(9):809-15. PMID: 11533660.
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  243. Vincent S, Perkins LA, Perrimon N. Doublesex surprises. Cell. 2001 Aug 24; 106(4):399-402. PMID: 11525726.
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  244. Stronach BE, Perrimon N. Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryo. Development. 2001 Aug; 128(15):2905-13. PMID: 11532914.
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  245. Vincent S, Perrimon N. Developmental biology. Fishing for morphogens. Nature. 2001 May 31; 411(6837):533, 535-6. PMID: 11385549.
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  246. Perrimon N, Bernfield M. Cellular functions of proteoglycans--an overview. Semin Cell Dev Biol. 2001 Apr; 12(2):65-7. PMID: 11292371.
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  247. Bai J, Chiu W, Wang J, Tzeng T, Perrimon N, Hsu J. The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway. Development. 2001 Feb; 128(4):591-601. PMID: 11171342.
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  248. Baeg GH, Lin X, Khare N, Baumgartner S, Perrimon N. Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development. 2001 Jan; 128(1):87-94. PMID: 11092814.
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  249. Selva EM, Perrimon N. Role of heparan sulfate proteoglycans in cell signaling and cancer. Adv Cancer Res. 2001; 83:67-80. PMID: 11665721.
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  250. Zeidler MP, Perrimon N, Strutt DI. Multiple roles for four-jointed in planar polarity and limb patterning. Dev Biol. 2000 Dec 15; 228(2):181-96. PMID: 11112323.
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  251. Noll E, Medina M, Hartley D, Zhou J, Perrimon N, Kosik KS. Presenilin affects arm/beta-catenin localization and function in Drosophila. Dev Biol. 2000 Nov 15; 227(2):450-64. PMID: 11071766.
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  252. Noselli S, Perrimon N. Signal transduction. Are there close encounters between signaling pathways? Science. 2000 Oct 6; 290(5489):68-9. PMID: 11183153.
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  253. Li W, Noll E, Perrimon N. Identification of autosomal regions involved in Drosophila Raf function. Genetics. 2000 Oct; 156(2):763-74. PMID: 11014822; PMCID: PMC1461272.
  254. Baeg GH, Perrimon N. Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila. Curr Opin Cell Biol. 2000 Oct; 12(5):575-80. PMID: 10978892.
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  255. Zeidler MP, Perrimon N. Sex determination: co-opted signals determine gender. Curr Biol. 2000 Sep 21; 10(18):R682-4. PMID: 10996811.
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  256. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000 Aug 24; 10(16):964-73. PMID: 10985383.
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  257. Lin X, Perrimon N. Role of heparan sulfate proteoglycans in cell-cell signaling in Drosophila. Matrix Biol. 2000 Aug; 19(4):303-7. PMID: 10963990.
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  258. Bilder D, Li M, Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 2000 Jul 7; 289(5476):113-6. PMID: 10884224.
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  259. Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T. The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem. 2000 Jul; 267(13):4300-11. PMID: 10866835.
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  260. Bilder D, Birnbaum D, Borg JP, Bryant P, Huigbretse J, Jansen E, Kennedy MB, Labouesse M, Legouis R, Mechler B, Perrimon N, Petit M, Sinha P. Collective nomenclature for LAP proteins. Nat Cell Biol. 2000 Jul; 2(7):E114. PMID: 10878817.
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  261. Zeidler MP, Bach EA, Perrimon N. The roles of the Drosophila JAK/STAT pathway. Oncogene. 2000 May 15; 19(21):2598-606. PMID: 10851058.
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  262. The I, Perrimon N. Morphogen diffusion: the case of the wingless protein. Nat Cell Biol. 2000 May; 2(5):E79-82. PMID: 10806491.
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  263. Perrimon N, Bernfield M. Specificities of heparan sulphate proteoglycans in developmental processes. Nature. 2000 Apr 13; 404(6779):725-8. PMID: 10783877.
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  264. Boutros M, Perrimon N. Drosophila genome takes flight. Nat Cell Biol. 2000 Apr; 2(4):E53-4. PMID: 10783247.
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  265. Bilder D, Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. 2000 Feb 10; 403(6770):676-80. PMID: 10688207.
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  266. Zeidler MP, Perrimon N, Strutt DI. The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification. Curr Biol. 1999 Dec 2; 9(23):1363-72. PMID: 10607560.
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  267. Martín-Blanco E, Roch F, Noll E, Baonza A, Duffy JB, Perrimon N. A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. Development. 1999 Dec; 126(24):5739-47. PMID: 10572049.
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  268. Stronach BE, Perrimon N. Stress signaling in Drosophila. Oncogene. 1999 Nov 1; 18(45):6172-82. PMID: 10557109.
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  269. The I, Bellaiche Y, Perrimon N. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol Cell. 1999 Oct; 4(4):633-9. PMID: 10549295.
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  270. Lin X, Buff EM, Perrimon N, Michelson AM. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Development. 1999 Sep; 126(17):3715-23. PMID: 10433902.
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  271. Perrimon N, Stern C. Pattern formation and developmental mechanisms unresolved issues of pattern formation Curr Opin Genet Dev. 1999 Aug; 9(4):387-9. PMID: 10449360.
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  272. Spana E, Perrimon N. The latest in signal transduction, 1999. Specificity in Signal Transduction, Keystone, Colorado, USA, 9-14 April 1999. Trends Genet. 1999 Aug; 15(8):301-2. PMID: 10475855.
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  273. Lin X, Perrimon N. Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling. Nature. 1999 Jul 15; 400(6741):281-4. PMID: 10421372.
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  274. Bellaiche Y, Mogila V, Perrimon N. I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila. Genetics. 1999 Jul; 152(3):1037-44. PMID: 10388822; PMCID: PMC1460675.
  275. Zeidler MP, Perrimon N, Strutt DI. Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling. Genes Dev. 1999 May 15; 13(10):1342-53. PMID: 10346822; PMCID: PMC316719.
  276. Perrimon N, McMahon AP. Negative feedback mechanisms and their roles during pattern formation. Cell. 1999 Apr 2; 97(1):13-6. PMID: 10199398.
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  277. Ghiglione C, Carraway KL, Amundadottir LT, Boswell RE, Perrimon N, Duffy JB. The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell. 1999 Mar 19; 96(6):847-56. PMID: 10102272.
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  278. Gayko U, Cleghon V, Copeland T, Morrison DK, Perrimon N. Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):523-8. PMID: 9892666; PMCID: PMC15169.
  279. Mogila VA, Bellaiche Y, Perrimon N. Expression of I-Sce I in Drosophila to induce DNA double-strand breaks. Methods Mol Biol. 1999; 113:439-45. PMID: 10443440.
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  280. Ghiglione C, Perrimon N, Perkins LA. Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila. Dev Biol. 1999 Jan 1; 205(1):181-93. PMID: 9882506.
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  281. Li W, Melnick M, Perrimon N. Dual function of Ras in Raf activation. Development. 1998 Dec; 125(24):4999-5008. PMID: 9811584.
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  282. Cleghon V, Feldmann P, Ghiglione C, Copeland TD, Perrimon N, Hughes DA, Morrison DK. Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Mol Cell. 1998 Dec; 2(6):719-27. PMID: 9885560.
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  283. Perrimon N, Duffy JB. Developmental biology. Sending all the right signals. Nature. 1998 Nov 5; 396(6706):18-9. PMID: 9817197.
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  284. Shulman JM, Perrimon N, Axelrod JD. Frizzled signaling and the developmental control of cell polarity. Trends Genet. 1998 Nov; 14(11):452-8. PMID: 9825673.
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  285. Harrison DA, McCoon PE, Binari R, Gilman M, Perrimon N. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev. 1998 Oct 15; 12(20):3252-63. PMID: 9784499; PMCID: PMC317220.
  286. Perrimon N. New advances in Drosophila provide opportunities to study gene functions. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9716-7. PMID: 9707540; PMCID: PMC33881.
  287. Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 1998 Aug 15; 12(16):2610-22. PMID: 9716412; PMCID: PMC317102.
  288. Bellaiche Y, The I, Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature. 1998 Jul 2; 394(6688):85-8. PMID: 9665133.
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  289. Perrimon N, Nusse R. Highlights of the 1998 Wnt meeting, Cambridge, MA, January 9-11. Biochim Biophys Acta. 1998 Jun 19; 1377(3):R45-9. PMID: 9659404.
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  290. Duffy JB, Harrison DA, Perrimon N. Identifying loci required for follicular patterning using directed mosaics. Development. 1998 Jun; 125(12):2263-71. PMID: 9584125.
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  291. Mathey-Prevot B, Perrimon N. Mammalian and Drosophila blood: JAK of all trades? Cell. 1998 Mar 20; 92(6):697-700. PMID: 9529244.
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  292. Häcker U, Perrimon N. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 1998 Jan 15; 12(2):274-84. PMID: 9436986; PMCID: PMC316438.
  293. Perrimon N. Creating mosaics in Drosophila. Int J Dev Biol. 1998; 42(3):243-7. PMID: 9654004.
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  294. Eberl DF, Duyk GM, Perrimon N. A genetic screen for mutations that disrupt an auditory response in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14837-42. PMID: 9405700; PMCID: PMC25124.
  295. Riesgo-Escovar JR, Hafen E, Hou XS, Goldstein ES, Perrimon N, Glise B, Noselli S, Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D. Connecting up the pathways in Drosophila development. Trends Cell Biol. 1997 Nov; 7(11):421-2. PMID: 17708993.
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  296. Goode S, Perrimon N. Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis. Genes Dev. 1997 Oct 1; 11(19):2532-44. PMID: 9334318; PMCID: PMC316565.
  297. Li W, Skoulakis EM, Davis RL, Perrimon N. The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner. Development. 1997 Oct; 124(20):4163-71. PMID: 9374412.
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  298. Häcker U, Lin X, Perrimon N. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. Development. 1997 Sep; 124(18):3565-73. PMID: 9342049.
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  299. Eberl DF, Lorenz LJ, Melnick MB, Sood V, Lasko P, Perrimon N. A new enhancer of position-effect variegation in Drosophila melanogaster encodes a putative RNA helicase that binds chromosomes and is regulated by the cell cycle. Genetics. 1997 Jul; 146(3):951-63. PMID: 9215899; PMCID: PMC1208063.
  300. Hou XS, Goldstein ES, Perrimon N. Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes Dev. 1997 Jul 1; 11(13):1728-37. PMID: 9224721.
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  301. Perrimon N, Perkins LA. There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor. Cell. 1997 Apr 4; 89(1):13-6. PMID: 9094709.
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  302. Hou XS, Perrimon N. The JAK-STAT pathway in Drosophila. Trends Genet. 1997 Mar; 13(3):105-10. PMID: 9066269.
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  303. Yu Y, Li W, Su K, Yussa M, Han W, Perrimon N, Pick L. The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz. Nature. 1997 Feb 6; 385(6616):552-5. PMID: 9020364.
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  304. Li W, Perrimon N. Specificity of receptor tyrosine kinase signaling pathways: lessons from Drosophila. Genet Eng (N Y). 1997; 19:167-82. PMID: 9193108.
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  305. Goode S, Perrimon N. Brainiac and fringe are similar pioneer proteins that impart specificity to notch signaling during Drosophila development. Cold Spring Harb Symp Quant Biol. 1997; 62:177-84. PMID: 9598350.
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  306. Engstrom L, Noll E, Perrimon N. Paradigms to study signal transduction pathways in Drosophila. Curr Top Dev Biol. 1997; 35:229-61. PMID: 9292272.
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  307. Kadowaki T, Wilder E, Klingensmith J, Zachary K, Perrimon N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 1996 Dec 15; 10(24):3116-28. PMID: 8985181.
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  308. Chou TB, Perrimon N. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics. 1996 Dec; 144(4):1673-9. PMID: 8978054; PMCID: PMC1207718.
  309. Perrimon N, Lanjuin A, Arnold C, Noll E. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics. 1996 Dec; 144(4):1681-92. PMID: 8978055; PMCID: PMC1207719.
  310. Goode S, Melnick M, Chou TB, Perrimon N. The neurogenic genes egghead and brainiac define a novel signaling pathway essential for epithelial morphogenesis during Drosophila oogenesis. Development. 1996 Dec; 122(12):3863-79. PMID: 9012507.
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  311. Perkins LA, Johnson MR, Melnick MB, Perrimon N. The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev Biol. 1996 Nov 25; 180(1):63-81. PMID: 8948575.
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  312. Rulifson EJ, Micchelli CA, Axelrod JD, Perrimon N, Blair SS. wingless refines its own expression domain on the Drosophila wing margin. Nature. 1996 Nov 7; 384(6604):72-4. PMID: 8900280.
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  313. Musacchio M, Perrimon N. The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS. Dev Biol. 1996 Aug 25; 178(1):63-76. PMID: 8812109.
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  314. Perrimon N. Serpentine proteins slither into the wingless and hedgehog fields. Cell. 1996 Aug 23; 86(4):513-6. PMID: 8752205.
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  315. Klingensmith J, Yang Y, Axelrod JD, Beier DR, Perrimon N, Sussman DJ. Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Mech Dev. 1996 Aug; 58(1-2):15-26. PMID: 8887313.
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  316. Duffy JB, Perrimon N. Recent advances in understanding signal transduction pathways in worms and flies. Curr Opin Cell Biol. 1996 Apr; 8(2):231-8. PMID: 8791421.
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  317. Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science. 1996 Mar 29; 271(5257):1826-32. PMID: 8596950.
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  318. Cleghon V, Gayko U, Copeland TD, Perkins LA, Perrimon N, Morrison DK. Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK. Genes Dev. 1996 Mar 1; 10(5):566-77. PMID: 8598287.
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  319. Hou XS, Melnick MB, Perrimon N. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell. 1996 Feb 9; 84(3):411-9. PMID: 8608595.
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  320. Perrimon N, Lu X, Hou XS, Hsu JC, Melnick MB, Chou TB, Perkins LA. Dissection of the Torso signal transduction pathway in Drosophila. Mol Reprod Dev. 1995 Dec; 42(4):515-22. PMID: 8607984.
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  321. Manoukian AS, Yoffe KB, Wilder EL, Perrimon N. The porcupine gene is required for wingless autoregulation in Drosophila. Development. 1995 Dec; 121(12):4037-44. PMID: 8575304.
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  322. Sokol SY, Klingensmith J, Perrimon N, Itoh K. Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development. 1995 Oct; 121(10):3487. PMID: 7588081.
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  323. Yin JC, Wallach JS, Wilder EL, Klingensmith J, Dang D, Perrimon N, Zhou H, Tully T, Quinn WG. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Mol Cell Biol. 1995 Sep; 15(9):5123-30. PMID: 7651429; PMCID: PMC230759.
  324. Yoffe KB, Manoukian AS, Wilder EL, Brand AH, Perrimon N. Evidence for engrailed-independent wingless autoregulation in Drosophila. Dev Biol. 1995 Aug; 170(2):636-50. PMID: 7649390.
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  325. Rivera-Pomar R, Lu X, Perrimon N, Taubert H, Jäckle H. Activation of posterior gap gene expression in the Drosophila blastoderm. Nature. 1995 Jul 20; 376(6537):253-6. PMID: 7617036.
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  326. Harrison DA, Binari R, Nahreini TS, Gilman M, Perrimon N. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 1995 Jun 15; 14(12):2857-65. PMID: 7796812; PMCID: PMC398404.
  327. Sokol SY, Klingensmith J, Perrimon N, Itoh K. Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development. 1995 Jun; 121(6):1637-47. PMID: 7600981.
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  328. Hou XS, Chou TB, Melnick MB, Perrimon N. The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell. 1995 Apr 7; 81(1):63-71. PMID: 7720074.
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  329. Perrimon N. Hedgehog and beyond. Cell. 1995 Feb 24; 80(4):517-20. PMID: 7867057.
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  330. Wilder EL, Perrimon N. Dual functions of wingless in the Drosophila leg imaginal disc. Development. 1995 Feb; 121(2):477-88. PMID: 7768188.
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  331. Duffy JB, Perrimon N. The torso pathway in Drosophila: lessons on receptor tyrosine kinase signaling and pattern formation. Dev Biol. 1994 Dec; 166(2):380-95. PMID: 7813764.
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  332. Sussman DJ, Klingensmith J, Salinas P, Adams PS, Nusse R, Perrimon N. Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol. 1994 Nov; 166(1):73-86. PMID: 7958461.
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  333. Perrimon N, Desplan C. Signal transduction in the early Drosophila embryo: when genetics meets biochemistry. Trends Biochem Sci. 1994 Nov; 19(11):509-13. PMID: 7855897.
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  334. Hsu JC, Perrimon N. A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases. Genes Dev. 1994 Sep 15; 8(18):2176-87. PMID: 7958887.
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  335. Siegfried E, Perrimon N. Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. Bioessays. 1994 Jun; 16(6):395-404. PMID: 8080429.
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  336. Lu X, Melnick MB, Hsu JC, Perrimon N. Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction. EMBO J. 1994 Jun 1; 13(11):2592-9. PMID: 8013459; PMCID: PMC395133.
  337. Perrimon N. Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila. Curr Opin Cell Biol. 1994 Apr; 6(2):260-6. PMID: 8024818.
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  338. Perrimon N. The genetic basis of patterned baldness in Drosophila. Cell. 1994 Mar 11; 76(5):781-4. PMID: 7907277.
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  339. Brand AH, Perrimon N. Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev. 1994 Mar 1; 8(5):629-39. PMID: 7926754.
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  340. Binari R, Perrimon N. Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev. 1994 Feb 1; 8(3):300-12. PMID: 8314084.
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  341. Siegfried E, Wilder EL, Perrimon N. Components of wingless signalling in Drosophila. Nature. 1994 Jan 6; 367(6458):76-80. PMID: 8107779.
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  342. Noordermeer J, Klingensmith J, Perrimon N, Nusse R. dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature. 1994 Jan 6; 367(6458):80-3. PMID: 7906389.
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  343. Brand AH, Manoukian AS, Perrimon N. Ectopic expression in Drosophila. Methods Cell Biol. 1994; 44:635-54. PMID: 7707973.
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  344. Klingensmith J, Nusse R, Perrimon N. The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev. 1994 Jan; 8(1):118-30. PMID: 8288125.
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  345. van den Heuvel M, Harryman-Samos C, Klingensmith J, Perrimon N, Nusse R. Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J. 1993 Dec 15; 12(13):5293-302. PMID: 8262072; PMCID: PMC413795.
  346. Chou TB, Noll E, Perrimon N. Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras. Development. 1993 Dec; 119(4):1359-69. PMID: 8306893.
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  347. Lu X, Perkins LA, Perrimon N. The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction. Development. 1993 Dec; 119 Suppl:47-56. PMID: 27002031.
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  348. van den Heuvel M, Klingensmith J, Perrimon N, Nusse R. Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. Development. 1993 Dec; 119 Suppl:105-14. PMID: 27002037.
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  349. Melnick MB, Noll E, Perrimon N. The Drosophila stubarista phenotype is associated with a dosage effect of the putative ribosome-associated protein D-p40 on spineless. Genetics. 1993 Oct; 135(2):553-64. PMID: 7916731; PMCID: PMC1205655.
  350. Perrimon N. The torso receptor protein-tyrosine kinase signaling pathway: an endless story. Cell. 1993 Jul 30; 74(2):219-22. PMID: 8343949.
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  351. Harrison DA, Perrimon N. Simple and efficient generation of marked clones in Drosophila. Curr Biol. 1993 Jul 1; 3(7):424-33. PMID: 15335709.
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  352. Brand AH, Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 1993 Jun; 118(2):401-15. PMID: 8223268.
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  353. Noll E, Perkins LA, Mahowald AP, Perrimon N. Approaches to identify genes involved in Drosophila embryonic CNS development. J Neurobiol. 1993 Jun; 24(6):701-22. PMID: 8331336.
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  354. Melnick MB, Perkins LA, Lee M, Ambrosio L, Perrimon N. Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. Development. 1993 May; 118(1):127-38. PMID: 8375330.
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  355. Lu X, Chou TB, Williams NG, Roberts T, Perrimon N. Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Genes Dev. 1993 Apr; 7(4):621-32. PMID: 8458578.
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  356. van den Heuvel M, Klingensmith J, Perrimon N, Nusse R. Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. Dev Suppl. 1993; 105-14. PMID: 8049466.
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  357. Lu X, Perkins LA, Perrimon N. The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction. Dev Suppl. 1993; 47-56. PMID: 8049487.
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  358. Siegfried E, Chou TB, Perrimon N. wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell. 1992 Dec 24; 71(7):1167-79. PMID: 1335365.
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  359. Rutledge BJ, Zhang K, Bier E, Jan YN, Perrimon N. The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev. 1992 Aug; 6(8):1503-17. PMID: 1644292.
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  360. Perkins LA, Larsen I, Perrimon N. corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell. 1992 Jul 24; 70(2):225-36. PMID: 1638629.
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  361. Chou TB, Perrimon N. Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila. Genetics. 1992 Jul; 131(3):643-53. PMID: 1628809; PMCID: PMC1205036.
  362. Wieschaus E, Perrimon N, Finkelstein R. orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila. Development. 1992 Jul; 115(3):801-11. PMID: 1425355.
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  363. Eberl DF, Perkins LA, Engelstein M, Hilliker AJ, Perrimon N. Genetic and developmental analysis of polytene section 17 of the X chromosome of Drosophila melanogaster. Genetics. 1992 Mar; 130(3):569-83. PMID: 1551578; PMCID: PMC1204874.
  364. Kassis JA, Noll E, VanSickle EP, Odenwald WF, Perrimon N. Altering the insertional specificity of a Drosophila transposable element. Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5):1919-23. PMID: 1311855; PMCID: PMC48565.
  365. Dang DT, Perrimon N. Use of a yeast site-specific recombinase to generate embryonic mosaics in Drosophila. Dev Genet. 1992; 13(5):367-75. PMID: 1292893.
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  366. Perkins LA, Perrimon N. The molecular genetics of tail development in Drosophila melanogaster. In Vivo. 1991 Sep-Oct; 5(5):521-31. PMID: 1768804.
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  367. Finkelstein R, Perrimon N. The molecular genetics of head development in Drosophila melanogaster. Development. 1991 Aug; 112(4):899-912. PMID: 1682131.
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  368. Zhang K, Smouse D, Perrimon N. The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes. Genes Dev. 1991 Jun; 5(6):1080-91. PMID: 2044955.
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  369. Perrimon N, Noll E, McCall K, Brand A. Generating lineage-specific markers to study Drosophila development. Dev Genet. 1991; 12(3):238-52. PMID: 1651183.
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  370. Siegfried E, Ambrosio L, Perrimon N. Serine/threonine protein kinases in Drosophila. Trends Genet. 1990 Nov; 6(11):357-62. PMID: 2150900.
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  371. Finkelstein R, Smouse D, Capaci TM, Spradling AC, Perrimon N. The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev. 1990 Sep; 4(9):1516-27. PMID: 1979296.
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  372. Finkelstein R, Perrimon N. The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature. 1990 Aug 2; 346(6283):485-8. PMID: 1974036.
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  373. Zhang K, Chaillet JR, Perkins LA, Halazonetis TD, Perrimon N. Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6281-5. PMID: 1696724; PMCID: PMC54517.
  374. Siegfried E, Perkins LA, Capaci TM, Perrimon N. Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3. Nature. 1990 Jun 28; 345(6278):825-9. PMID: 2113617.
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  375. Perkins LA, Doctor JS, Zhang K, Stinson L, Perrimon N, Craig EA. Molecular and developmental characterization of the heat shock cognate 4 gene of Drosophila melanogaster. Mol Cell Biol. 1990 Jun; 10(6):3232-8. PMID: 2111451; PMCID: PMC360688.
  376. Smouse D, Perrimon N. Genetic dissection of a complex neurological mutant, polyhomeotic, in Drosophila. Dev Biol. 1990 May; 139(1):169-85. PMID: 2328834.
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  377. Ambrosio L, Mahowald AP, Perrimon N. Requirement of the Drosophila raf homologue for torso function. Nature. 1989 Nov 16; 342(6247):288-91. PMID: 2554148.
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  378. Perrimon N, Smouse D. Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis. Dev Biol. 1989 Oct; 135(2):287-305. PMID: 2570722.
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  379. Klingensmith J, Noll E, Perrimon N. The segment polarity phenotype of Drosophila involves differential tendencies toward transformation and cell death. Dev Biol. 1989 Jul; 134(1):130-45. PMID: 2731645.
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  380. Ambrosio L, Mahowald AP, Perrimon N. l(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo. Development. 1989 May; 106(1):145-58. PMID: 2516795.
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  381. Ng SC, Perkins LA, Conboy G, Perrimon N, Fishman MC. A Drosophila gene expressed in the embryonic CNS shares one conserved domain with the mammalian GAP-43. Development. 1989 Mar; 105(3):629-38. PMID: 2693037.
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  382. Perrimon N, Smouse D, Miklos GL. Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster. Genetics. 1989 Feb; 121(2):313-31. PMID: 2499511; PMCID: PMC1203620.
  383. Perrimon N, Engstrom L, Mahowald AP. Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome. Genetics. 1989 Feb; 121(2):333-52. PMID: 2499512; PMCID: PMC1203621.
  384. Oliver B, Perrimon N, Mahowald AP. Genetic evidence that the sans fille locus is involved in Drosophila sex determination. Genetics. 1988 Sep; 120(1):159-71. PMID: 3220249; PMCID: PMC1203487.
  385. Smouse D, Goodman C, Mahowald A, Perrimon N. polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila. Genes Dev. 1988 Jul; 2(7):830-42. PMID: 2905316.
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  386. Perrimon N. The maternal effect of lethal(1)discs-large-1: a recessive oncogene of Drosophila melanogaster. Dev Biol. 1988 Jun; 127(2):392-407. PMID: 3132409.
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  387. Oliver B, Perrimon N, Mahowald AP. The ovo locus is required for sex-specific germ line maintenance in Drosophila. Genes Dev. 1987 Nov; 1(9):913-23. PMID: 3428601.
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  388. Mark GE, MacIntyre RJ, Digan ME, Ambrosio L, Perrimon N. Drosophila melanogaster homologs of the raf oncogene. Mol Cell Biol. 1987 Jun; 7(6):2134-40. PMID: 3037346; PMCID: PMC365335.
  389. Perrimon N, Mahowald AP. Multiple functions of segment polarity genes in Drosophila. Dev Biol. 1987 Feb; 119(2):587-600. PMID: 3803719.
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  390. Petschek JP, Perrimon N, Mahowald AP. Region-specific defects in l(1)giant embryos of Drosophila melanogaster. Dev Biol. 1987 Jan; 119(1):175-89. PMID: 3098602.
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  391. Perrimon N, Mahowald AP. l(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. Dev Biol. 1986 Nov; 118(1):28-41. PMID: 3095163.
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  392. Perrimon N, Mohler D, Engstrom L, Mahowald AP. X-linked female-sterile loci in Drosophila melanogaster. Genetics. 1986 Jul; 113(3):695-712. PMID: 3089870; PMCID: PMC1202863.
  393. Degelmann A, Hardy PA, Perrimon N, Mahowald AP. Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus. Dev Biol. 1986 Jun; 115(2):479-89. PMID: 3709971.
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  394. Perrimon N, Engstrom L, Mahowald AP. Developmental genetics of the 2C-D region of the Drosophila X chromosome. Genetics. 1985 Sep; 111(1):23-41. PMID: 3928431; PMCID: PMC1202596.
  395. Perrimon N, Engstrom L, Mahowald AP. A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster. Dev Biol. 1985 Aug; 110(2):480-91. PMID: 3926563.
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  396. Konrad KD, Engstrom L, Perrimon N, Mahowald AP. Genetic analysis of oogenesis and the role of maternal gene expression in early development. Dev Biol (N Y 1985). 1985; 1:577-617. PMID: 3917206.
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  397. Mortin MA, Perrimon N, Bonner JJ. Clonal analysis of two mutations in the large subunit of RNA polymerase II of Drosophila. Mol Gen Genet. 1985; 199(3):421-6. PMID: 3929014.
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  398. White RA, Perrimon N, Gehring WJ. Differentiation markers in the Drosophila ovary. J Embryol Exp Morphol. 1984 Dec; 84:275-86. PMID: 6442733.
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  399. Perrimon N. Clonal Analysis of Dominant Female-Sterile, Germline-Dependent Mutations in DROSOPHILA MELANOGASTER. Genetics. 1984 Dec; 108(4):927-39. PMID: 17246244.
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  400. Perrimon N, Engstrom L, Mahowald AP. Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in "developmentally important" genes. Genetics. 1984 Nov; 108(3):559-72. PMID: 6437900; PMCID: PMC1202425.
  401. Perrimon N, Engstrom L, Mahowald AP. The effects of zygotic lethal mutations on female germ-line functions in Drosophila. Dev Biol. 1984 Oct; 105(2):404-14. PMID: 6479445.
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  402. Perrimon N, Gans M. Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237. Dev Biol. 1983 Dec; 100(2):365-73. PMID: 6418585.
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