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profileJonathan Roger Beckwith, Ph.D.

TitleAmerican Cancer Society Professor of Microbiology and Immunobiology, Emeritus
InstitutionHarvard Medical School
DepartmentEmeritus
AddressHarvard Inst of Medicine
Microbiology and Immunobiology, Room 1047
4 Blackfan Cir
Boston MA 02115
Phone617/432-1920
Fax617/738-7664
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R03TW006003     (BECKWITH, JONATHAN R)Jul 1, 2002 - Jun 30, 2004
NIH/FIC
Characterization of the bacterial Arc system.
Role: Principal Investigator

R01GM055090     (BECKWITH, JONATHAN)Feb 1, 1998 - Jan 31, 2011
NIH/NIGMS
Disulfide Bond Formation: Mechanisms for Isomerization and Novel Pathways
Role: Principal Investigator

R01GM041883     (BOYD, DANA)Jun 1, 1989 - Feb 28, 2015
NIH/NIGMS
Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
Role: Co-Principal Investigator

R01GM038922     (BECKWITH, JONATHAN)Sep 1, 1987 - Feb 28, 2007
NIH/NIGMS
MEMBRANE PROTEINS INVOLVED IN CELL DIVISION IN E.COLI
Role: Principal Investigator

R37GM038922     (BECKWITH, JONATHAN R)Sep 1, 1987 - Aug 31, 1997
NIH/NIGMS
INSERTION AND TOPOLOGY OF MEMBRANE PROTEINS
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gonzalez MD, Akbay EA, Boyd D, Beckwith J. Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex. J Bacteriol. 2010 Jun; 192(11):2757-68. PMID: 20363951; PMCID: PMC2876486.
  2. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12. PMID: 20110994; PMCID: PMC2919313.
  3. Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):297-301. PMID: 20018758; PMCID: PMC2806739.
  4. Chung HS, Yao Z, Goehring NW, Kishony R, Beckwith J, Kahne D. Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21872-7. PMID: 19995973; PMCID: PMC2799840.
  5. Shouldice SR, Cho SH, Boyd D, Heras B, Eser M, Beckwith J, Riggs P, Martin JL, Berkmen M. In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling. Mol Microbiol. 2010 Jan; 75(1):13-28. PMID: 19968787.
    View in: PubMed
  6. Kadokura H, Beckwith J. Detecting folding intermediates of a protein as it passes through the bacterial translocation channel. Cell. 2009 Sep 18; 138(6):1164-73. PMID: 19766568; PMCID: PMC2750780.
  7. Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Gaucher E, Sanchez-Ruiz JM, Berne BJ, Fernandez JM. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nat Struct Mol Biol. 2009 Aug; 16(8):890-6. PMID: 19597482; PMCID: PMC2745927.
  8. Cho SH, Beckwith J. Two snapshots of electron transport across the membrane: insights into the structure and function of DsbD. J Biol Chem. 2009 Apr 24; 284(17):11416-24. PMID: 19258316; PMCID: PMC2670147.
  9. Gonzalez MD, Beckwith J. Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins. J Bacteriol. 2009 Apr; 191(8):2815-25. PMID: 19233928; PMCID: PMC2668415.
  10. Beckwith J. Genetic suppressors and recovery of repressed biochemical memory. J Biol Chem. 2009 May 08; 284(19):12585-92. PMID: 19129182; PMCID: PMC2675986.
  11. Zhou Y, Cierpicki T, Jimenez RH, Lukasik SM, Ellena JF, Cafiso DS, Kadokura H, Beckwith J, Bushweller JH. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol Cell. 2008 Sep 26; 31(6):896-908. PMID: 18922471; PMCID: PMC2622435.
  12. Dutton RJ, Boyd D, Berkmen M, Beckwith J. Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11933-8. PMID: 18695247; PMCID: PMC2575290.
  13. Robichon C, King GF, Goehring NW, Beckwith J. Artificial septal targeting of Bacillus subtilis cell division proteins in Escherichia coli: an interspecies approach to the study of protein-protein interactions in multiprotein complexes. J Bacteriol. 2008 Sep; 190(18):6048-59. PMID: 18621900; PMCID: PMC2546800.
  14. Faulkner MJ, Veeravalli K, Gon S, Georgiou G, Beckwith J. Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways. Proc Natl Acad Sci U S A. 2008 May 06; 105(18):6735-40. PMID: 18456836; PMCID: PMC2373332.
  15. Yamamoto Y, Ritz D, Planson AG, Jönsson TJ, Faulkner MJ, Boyd D, Beckwith J, Poole LB. Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity. Mol Cell. 2008 Jan 18; 29(1):36-45. PMID: 18206967; PMCID: PMC2239235.
  16. Ye J, Cho SH, Fuselier J, Li W, Beckwith J, Rapoport TA. Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem. 2007 Nov 30; 282(48):34945-51. PMID: 17913712.
    View in: PubMed
  17. Scheffers DJ, Robichon C, Haan GJ, den Blaauwen T, Koningstein G, van Bloois E, Beckwith J, Luirink J. Contribution of the FtsQ transmembrane segment to localization to the cell division site. J Bacteriol. 2007 Oct; 189(20):7273-80. PMID: 17693520; PMCID: PMC2168451.
  18. Cho SH, Porat A, Ye J, Beckwith J. Redox-active cysteines of a membrane electron transporter DsbD show dual compartment accessibility. EMBO J. 2007 Aug 08; 26(15):3509-20. PMID: 17641688; PMCID: PMC1948999.
  19. Beckwith J. What lies beyond uranus? Preconceptions, ignorance, serendipity and suppressors in the search for biology's secrets. Genetics. 2007 Jun; 176(2):733-40. PMID: 17579239; PMCID: PMC1894603.
  20. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21. PMID: 17531810.
    View in: PubMed
  21. Porat A, Lillig CH, Johansson C, Fernandes AP, Nilsson L, Holmgren A, Beckwith J. The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43. Biochemistry. 2007 Mar 20; 46(11):3366-77. PMID: 17305371; PMCID: PMC2518409.
  22. Goehring NW, Robichon C, Beckwith J. Role for the nonessential N terminus of FtsN in divisome assembly. J Bacteriol. 2007 Jan; 189(2):646-9. PMID: 17071748; PMCID: PMC1797402.
  23. Goehring NW, Petrovska I, Boyd D, Beckwith J. Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly. J Bacteriol. 2007 Jan; 189(2):633-45. PMID: 16980443; PMCID: PMC1797389.
  24. Goehring NW, Gonzalez MD, Beckwith J. Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly. Mol Microbiol. 2006 Jul; 61(1):33-45. PMID: 16824093.
    View in: PubMed
  25. Cho SH, Beckwith J. Mutations of the membrane-bound disulfide reductase DsbD that block electron transfer steps from cytoplasm to periplasm in Escherichia coli. J Bacteriol. 2006 Jul; 188(14):5066-76. PMID: 16816179; PMCID: PMC1539965.
  26. Gon S, Faulkner MJ, Beckwith J. In vivo requirement for glutaredoxins and thioredoxins in the reduction of the ribonucleotide reductases of Escherichia coli. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):735-42. PMID: 16771665.
    View in: PubMed
  27. Gon S, Beckwith J. Ribonucleotide reductases: influence of environment on synthesis and activity. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):773-80. PMID: 16771669.
    View in: PubMed
  28. Gon S, Camara JE, Klungsøyr HK, Crooke E, Skarstad K, Beckwith J. A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli. EMBO J. 2006 Mar 08; 25(5):1137-47. PMID: 16482221; PMCID: PMC1409723.
  29. Huber D, Cha MI, Debarbieux L, Planson AG, Cruz N, López G, Tasayco ML, Chaffotte A, Beckwith J. A selection for mutants that interfere with folding of Escherichia coli thioredoxin-1 in vivo. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18872-7. PMID: 16357193; PMCID: PMC1323206.
  30. Beckwith J, Huang F. Should we make a fuss? A case for social responsibility in science. Nat Biotechnol. 2005 Dec; 23(12):1479-80. PMID: 16333283.
    View in: PubMed
  31. Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. J Biol Chem. 2006 Feb 24; 281(8):4911-9. PMID: 16280324.
    View in: PubMed
  32. Goehring NW, Beckwith J. Diverse paths to midcell: assembly of the bacterial cell division machinery. Curr Biol. 2005 Jul 12; 15(13):R514-26. PMID: 16005287.
    View in: PubMed
  33. Sevier CS, Kadokura H, Tam VC, Beckwith J, Fass D, Kaiser CA. The prokaryotic enzyme DsbB may share key structural features with eukaryotic disulfide bond forming oxidoreductases. Protein Sci. 2005 Jun; 14(6):1630-42. PMID: 15930008; PMCID: PMC2253379.
  34. Huber D, Boyd D, Xia Y, Olma MH, Gerstein M, Beckwith J. Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition particle-dependent translocation. J Bacteriol. 2005 May; 187(9):2983-91. PMID: 15838024; PMCID: PMC1082830.
  35. Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N. An open letter to Elias Zerhouni. Science. 2005 Mar 04; 307(5714):1409-10. PMID: 15746409.
    View in: PubMed
  36. Kadokura H, Nichols L, Beckwith J. Mutational alterations of the key cis proline residue that cause accumulation of enzymatic reaction intermediates of DsbA, a member of the thioredoxin superfamily. J Bacteriol. 2005 Feb; 187(4):1519-22. PMID: 15687218; PMCID: PMC545618.
  37. Berkmen M, Boyd D, Beckwith J. The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC. J Biol Chem. 2005 Mar 25; 280(12):11387-94. PMID: 15642731.
    View in: PubMed
  38. Goehring NW, Gueiros-Filho F, Beckwith J. Premature targeting of a cell division protein to midcell allows dissection of divisome assembly in Escherichia coli. Genes Dev. 2005 Jan 01; 19(1):127-37. PMID: 15630023; PMCID: PMC540231.
  39. Or E, Boyd D, Gon S, Beckwith J, Rapoport T. The bacterial ATPase SecA functions as a monomer in protein translocation. J Biol Chem. 2005 Mar 11; 280(10):9097-105. PMID: 15618215.
    View in: PubMed
  40. Porat A, Cho SH, Beckwith J. The unusual transmembrane electron transporter DsbD and its homologues: a bacterial family of disulfide reductases. Res Microbiol. 2004 Oct; 155(8):617-22. PMID: 15380548.
    View in: PubMed
  41. Buddelmeijer N, Beckwith J. A complex of the Escherichia coli cell division proteins FtsL, FtsB and FtsQ forms independently of its localization to the septal region. Mol Microbiol. 2004 Jun; 52(5):1315-27. PMID: 15165235.
    View in: PubMed
  42. Ortenberg R, Gon S, Porat A, Beckwith J. Interactions of glutaredoxins, ribonucleotide reductase, and components of the DNA replication system of Escherichia coli. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7439-44. PMID: 15123823; PMCID: PMC409937.
  43. Kadokura H, Tian H, Zander T, Bardwell JC, Beckwith J. Snapshots of DsbA in action: detection of proteins in the process of oxidative folding. Science. 2004 Jan 23; 303(5657):534-7. PMID: 14739460.
    View in: PubMed
  44. Belin D, Guzman LM, Bost S, Konakova M, Silva F, Beckwith J. Functional activity of eukaryotic signal sequences in Escherichia coli: the ovalbumin family of serine protease inhibitors. J Mol Biol. 2004 Jan 09; 335(2):437-53. PMID: 14672654.
    View in: PubMed
  45. Beckwith J. An active life in science. Interview by Holger Breithaupt and Caroline Hadley. EMBO Rep. 2004 Jan; 5(1):12-5. PMID: 14710176; PMCID: PMC1298971.
  46. Schierle CF, Berkmen M, Huber D, Kumamoto C, Boyd D, Beckwith J. The DsbA signal sequence directs efficient, cotranslational export of passenger proteins to the Escherichia coli periplasm via the signal recognition particle pathway. J Bacteriol. 2003 Oct; 185(19):5706-13. PMID: 13129941; PMCID: PMC193964.
  47. Brandon LD, Goehring N, Janakiraman A, Yan AW, Wu T, Beckwith J, Goldberg MB. IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributed. Mol Microbiol. 2003 Oct; 50(1):45-60. PMID: 14507362.
    View in: PubMed
  48. Katzen F, Beckwith J. Role and location of the unusual redox-active cysteines in the hydrophobic domain of the transmembrane electron transporter DsbD. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10471-6. PMID: 12925743; PMCID: PMC193585.
  49. Ortenberg R, Beckwith J. Functions of thiol-disulfide oxidoreductases in E. coli: redox myths, realities, and practicalities. Antioxid Redox Signal. 2003 Aug; 5(4):403-11. PMID: 13678528.
    View in: PubMed
  50. Toutain CM, Clarke DJ, Leeds JA, Kuhn J, Beckwith J, Holland IB, Jacq A. The transmembrane domain of the DnaJ-like protein DjlA is a dimerisation domain. Mol Genet Genomics. 2003 Mar; 268(6):761-70. PMID: 12655402.
    View in: PubMed
  51. Kadokura H, Katzen F, Beckwith J. Protein disulfide bond formation in prokaryotes. Annu Rev Biochem. 2003; 72:111-35. PMID: 12524212.
    View in: PubMed
  52. Buddelmeijer N, Beckwith J. Assembly of cell division proteins at the E. coli cell center. Curr Opin Microbiol. 2002 Dec; 5(6):553-7. PMID: 12457697.
    View in: PubMed
  53. Haebel PW, Goldstone D, Katzen F, Beckwith J, Metcalf P. The disulfide bond isomerase DsbC is activated by an immunoglobulin-fold thiol oxidoreductase: crystal structure of the DsbC-DsbDalpha complex. EMBO J. 2002 Sep 16; 21(18):4774-84. PMID: 12234918; PMCID: PMC126285.
  54. Katzen F, Deshmukh M, Daldal F, Beckwith J. Evolutionary domain fusion expanded the substrate specificity of the transmembrane electron transporter DsbD. EMBO J. 2002 Aug 01; 21(15):3960-9. PMID: 12145197; PMCID: PMC126151.
  55. Jurado P, Ritz D, Beckwith J, de Lorenzo V, Fernández LA. Production of functional single-chain Fv antibodies in the cytoplasm of Escherichia coli. J Mol Biol. 2002 Jun 28; 320(1):1-10. PMID: 12079330.
    View in: PubMed
  56. Kadokura H, Beckwith J. Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA. EMBO J. 2002 May 15; 21(10):2354-63. PMID: 12006488; PMCID: PMC126001.
  57. Buddelmeijer N, Judson N, Boyd D, Mekalanos JJ, Beckwith J. YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6316-21. PMID: 11972052; PMCID: PMC122946.
  58. Chen JC, Minev M, Beckwith J. Analysis of ftsQ mutant alleles in Escherichia coli: complementation, septal localization, and recruitment of downstream cell division proteins. J Bacteriol. 2002 Feb; 184(3):695-705. PMID: 11790739; PMCID: PMC139535.
  59. Ritz D, Beckwith J. Redox state of cytoplasmic thioredoxin. Methods Enzymol. 2002; 347:360-70. PMID: 11898427.
    View in: PubMed
  60. Katzen F, Beckwith J. Disulfide bond formation in periplasm of Escherichia coli. Methods Enzymol. 2002; 348:54-66. PMID: 11885294.
    View in: PubMed
  61. Tian H, Beckwith J. Genetic screen yields mutations in genes encoding all known components of the Escherichia coli signal recognition particle pathway. J Bacteriol. 2002 Jan; 184(1):111-8. PMID: 11741850; PMCID: PMC134764.
  62. Kadokura H, Beckwith J. The expanding world of oxidative protein folding. Nat Cell Biol. 2001 Nov; 3(11):E247-9. PMID: 11715032.
    View in: PubMed
  63. Leeds JA, Boyd D, Huber DR, Sonoda GK, Luu HT, Engelman DM, Beckwith J. Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library. J Mol Biol. 2001 Oct 12; 313(1):181-95. PMID: 11601855.
    View in: PubMed
  64. Ritz D, Lim J, Reynolds CM, Poole LB, Beckwith J. Conversion of a peroxiredoxin into a disulfide reductase by a triplet repeat expansion. Science. 2001 Oct 05; 294(5540):158-60. PMID: 11588261.
    View in: PubMed
  65. Chen JC, Beckwith J. FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division. Mol Microbiol. 2001 Oct; 42(2):395-413. PMID: 11703663.
    View in: PubMed
  66. Goldstone D, Haebel PW, Katzen F, Bader MW, Bardwell JC, Beckwith J, Metcalf P. DsbC activation by the N-terminal domain of DsbD. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9551-6. PMID: 11493705; PMCID: PMC55490.
  67. Beckwith J. On the social responsibility of scientists. Ann Ist Super Sanita. 2001; 37(2):189-94. PMID: 11758276.
    View in: PubMed
  68. Ritz D, Beckwith J. Roles of thiol-redox pathways in bacteria. Annu Rev Microbiol. 2001; 55:21-48. PMID: 11544348.
    View in: PubMed
  69. Katzen F, Beckwith J. Transmembrane electron transfer by the membrane protein DsbD occurs via a disulfide bond cascade. Cell. 2000 Nov 22; 103(5):769-79. PMID: 11114333.
    View in: PubMed
  70. Kadokura H, Bader M, Tian H, Bardwell JC, Beckwith J. Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10884-9. PMID: 11005861; PMCID: PMC27118.
  71. Alper JS, Beckwith J. On the philosophical analysis of genetic essentialism. Commentary on: "The use of genetic test information in insurance: the argument from indistinguishability reconsidered". Sci Eng Ethics. 2000 Jul; 6(3):311-4. PMID: 11273457.
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  72. Tian H, Boyd D, Beckwith J. A mutant hunt for defects in membrane protein assembly yields mutations affecting the bacterial signal recognition particle and Sec machinery. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4730-5. PMID: 10781078; PMCID: PMC18301.
  73. Boyd D, Weiss DS, Chen JC, Beckwith J. Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda InCh, a simple Escherichia coli plasmid-chromosome shuttle system. J Bacteriol. 2000 Feb; 182(3):842-7. PMID: 10633125; PMCID: PMC94354.
  74. Debarbieux L, Beckwith J. On the functional interchangeability, oxidant versus reductant, of members of the thioredoxin superfamily. J Bacteriol. 2000 Feb; 182(3):723-7. PMID: 10633106; PMCID: PMC94335.
  75. Ritz D, Patel H, Doan B, Zheng M, Aslund F, Storz G, Beckwith J. Thioredoxin 2 is involved in the oxidative stress response in Escherichia coli. J Biol Chem. 2000 Jan 28; 275(4):2505-12. PMID: 10644706.
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  76. Ghigo JM, Beckwith J. Cell division in Escherichia coli: role of FtsL domains in septal localization, function, and oligomerization. J Bacteriol. 2000 Jan; 182(1):116-29. PMID: 10613870; PMCID: PMC94247.
  77. Leeds JA, Beckwith J. A gene fusion method for assaying interactions of protein transmembrane segments in vivo. Methods Enzymol. 2000; 327:165-75. PMID: 11044981.
    View in: PubMed
  78. Beckwith J. The all purpose gene fusion. Methods Enzymol. 2000; 326:3-7. PMID: 11036631.
    View in: PubMed
  79. Bessette PH, Aslund F, Beckwith J, Georgiou G. Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13703-8. PMID: 10570136; PMCID: PMC24128.
  80. Stewart EJ, Katzen F, Beckwith J. Six conserved cysteines of the membrane protein DsbD are required for the transfer of electrons from the cytoplasm to the periplasm of Escherichia coli. EMBO J. 1999 Nov 01; 18(21):5963-71. PMID: 10545108; PMCID: PMC1171662.
  81. Debarbieux L, Beckwith J. Electron avenue: pathways of disulfide bond formation and isomerization. Cell. 1999 Oct 15; 99(2):117-9. PMID: 10535729.
    View in: PubMed
  82. Mössner E, Huber-Wunderlich M, Rietsch A, Beckwith J, Glockshuber R, Aslund F. Importance of redox potential for the in vivo function of the cytoplasmic disulfide reductant thioredoxin from Escherichia coli. J Biol Chem. 1999 Sep 03; 274(36):25254-9. PMID: 10464247.
    View in: PubMed
  83. Alper JS, Beckwith J. Racism: a central problem for the Human Genome Diversity Project. Politics Life Sci. 1999 Sep; 18(2):285-8. PMID: 12542056.
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  84. Aslund F, Zheng M, Beckwith J, Storz G. Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6161-5. PMID: 10339558; PMCID: PMC26852.
  85. Aslund F, Beckwith J. Bridge over troubled waters: sensing stress by disulfide bond formation. Cell. 1999 Mar 19; 96(6):751-3. PMID: 10102262.
    View in: PubMed
  86. Aslund F, Beckwith J. The thioredoxin superfamily: redundancy, specificity, and gray-area genomics. J Bacteriol. 1999 Mar; 181(5):1375-9. PMID: 10049365; PMCID: PMC93523.
  87. Chen JC, Weiss DS, Ghigo JM, Beckwith J. Septal localization of FtsQ, an essential cell division protein in Escherichia coli. J Bacteriol. 1999 Jan; 181(2):521-30. PMID: 9882666; PMCID: PMC93406.
  88. Ghigo JM, Weiss DS, Chen JC, Yarrow JC, Beckwith J. Localization of FtsL to the Escherichia coli septal ring. Mol Microbiol. 1999 Jan; 31(2):725-37. PMID: 10027987.
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  89. Weiss DS, Chen JC, Ghigo JM, Boyd D, Beckwith J. Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL. J Bacteriol. 1999 Jan; 181(2):508-20. PMID: 9882665; PMCID: PMC93405.
  90. Stewart EJ, Aslund F, Beckwith J. Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins. EMBO J. 1998 Oct 01; 17(19):5543-50. PMID: 9755155; PMCID: PMC1170883.
  91. Debarbieux L, Beckwith J. The reductive enzyme thioredoxin 1 acts as an oxidant when it is exported to the Escherichia coli periplasm. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10751-6. PMID: 9724776; PMCID: PMC27967.
  92. Leeds JA, Beckwith J. Lambda repressor N-terminal DNA-binding domain as an assay for protein transmembrane segment interactions in vivo. J Mol Biol. 1998 Jul 31; 280(5):799-810. PMID: 9671551.
    View in: PubMed
  93. Prinz WA, Boyd DH, Ehrmann M, Beckwith J. The protein translocation apparatus contributes to determining the topology of an integral membrane protein in Escherichia coli. J Biol Chem. 1998 Apr 03; 273(14):8419-24. PMID: 9525953.
    View in: PubMed
  94. Alper JS, Beckwith J. Distinguishing genetic from nongenetic medical tests: some implications for antidiscrimination legislation. Sci Eng Ethics. 1998 Apr; 4(2):141-50. PMID: 11657770.
    View in: PubMed
  95. Boyd D, Schierle C, Beckwith J. How many membrane proteins are there? Protein Sci. 1998 Jan; 7(1):201-5. PMID: 9514275; PMCID: PMC2143806.
  96. Beckwith J, Alper JS. Reconsidering genetic antidiscrimination legislation. J Law Med Ethics. 1998; 26(3):205-10, 178. PMID: 11066878.
    View in: PubMed
  97. Rietsch A, Beckwith J. The genetics of disulfide bond metabolism. Annu Rev Genet. 1998; 32:163-84. PMID: 9928478.
    View in: PubMed
  98. Pohlschröder M, Prinz WA, Hartmann E, Beckwith J. Protein translocation in the three domains of life: variations on a theme. Cell. 1997 Nov 28; 91(5):563-6. PMID: 9393849.
    View in: PubMed
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  105. Pogliano J, Pogliano K, Weiss DS, Losick R, Beckwith J. Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):559-64. PMID: 9012823; PMCID: PMC19552.
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  108. Pohlschröder M, Murphy C, Beckwith J. In vivo analyses of interactions between SecE and SecY, core components of the Escherichia coli protein translocation machinery. J Biol Chem. 1996 Aug 16; 271(33):19908-14. PMID: 8702704.
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  109. Allen A, Anderson B, Andrews L, Beckwith J, Bowman J, Cook-Deegan R, Cox D, Duster T, Eisenberg R, Fine B, Holtzman N, King P, Kitcher P, McInerney J, McKusick V, Mulvihill J, Murray J, Murray R, Murray T, Nelkin D, Rapp R, Saxton M, Wexler N. The Bell Curve: statement by the NIH-DOE Joint Working Group on the Ethical, Legal, and Social Implications of Human Genome Research. Am J Hum Genet. 1996 Aug; 59(2):487-8. PMID: 8755944; PMCID: PMC1914721.
  110. Jander G, Cronan JE, Beckwith J. Biotinylation in vivo as a sensitive indicator of protein secretion and membrane protein insertion. J Bacteriol. 1996 Jun; 178(11):3049-58. PMID: 8655479; PMCID: PMC178051.
  111. Geller LN, Alper JS, Billings PR, Barash CI, Beckwith J, Natowicz MR. Individual, family, and societal dimensions of genetic discrimination: a case study analysis. Sci Eng Ethics. 1996 Jan; 2(1):71-88. PMID: 11657787.
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  114. Guzman LM, Belin D, Carson MJ, Beckwith J. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol. 1995 Jul; 177(14):4121-30. PMID: 7608087; PMCID: PMC177145.
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  117. Barondess JJ, Beckwith J. bor gene of phage lambda, involved in serum resistance, encodes a widely conserved outer membrane lipoprotein. J Bacteriol. 1995 Mar; 177(5):1247-53. PMID: 7868598; PMCID: PMC176730.
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  121. Murphy CK, Beckwith J. Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2557-61. PMID: 8146153; PMCID: PMC43408.
  122. Pogliano KJ, Beckwith J. Genetic and molecular characterization of the Escherichia coli secD operon and its products. J Bacteriol. 1994 Feb; 176(3):804-14. PMID: 7507921; PMCID: PMC205118.
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  125. Alper JS, Beckwith J. Genetic fatalism and social policy: the implications of behavior genetics research. Yale J Biol Med. 1993 Nov-Dec; 66(6):511-24. PMID: 7716971; PMCID: PMC2588854.
  126. Bardwell JC, Beckwith J. The bonds that tie: catalyzed disulfide bond formation. Cell. 1993 Sep 10; 74(5):769-71. PMID: 8374949.
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  127. Geller LN, Ahn AH, Beckwith J, Barash C. Insurance commissioners and genetic discrimination. Am J Hum Genet. 1993 May; 52(5):1018. PMID: 8488834; PMCID: PMC1682034.
  128. Martin JL, Waksman G, Bardwell JC, Beckwith J, Kuriyan J. Crystallization of DsbA, an Escherichia coli protein required for disulphide bond formation in vivo. J Mol Biol. 1993 Apr 05; 230(3):1097-100. PMID: 8478925.
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  129. Pogliano KJ, Beckwith J. The Cs sec mutants of Escherichia coli reflect the cold sensitivity of protein export itself. Genetics. 1993 Apr; 133(4):763-73. PMID: 8462840; PMCID: PMC1205398.
  130. Derman AI, Puziss JW, Bassford PJ, Beckwith J. A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J. 1993 Mar; 12(3):879-88. PMID: 8458344; PMCID: PMC413286.
  131. Bardwell JC, Lee JO, Jander G, Martin N, Belin D, Beckwith J. A pathway for disulfide bond formation in vivo. Proc Natl Acad Sci U S A. 1993 Feb 01; 90(3):1038-42. PMID: 8430071; PMCID: PMC45806.
  132. Traxler B, Boyd D, Beckwith J. The topological analysis of integral cytoplasmic membrane proteins. J Membr Biol. 1993 Feb; 132(1):1-11. PMID: 8459445.
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  135. Guzman LM, Barondess JJ, Beckwith J. FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli. J Bacteriol. 1992 Dec; 174(23):7716-28. PMID: 1332942; PMCID: PMC207486.
  136. Traxler B, Beckwith J. Assembly of a hetero-oligomeric membrane protein complex. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10852-6. PMID: 1438288; PMCID: PMC50440.
  137. Billings PR, Alper JS, Beckwith J, Barash CI, Natowicz MR. Reply to Hook and Lowden: the definition and implications of genetic discrimination. Am J Hum Genet. 1992 Oct; 51(4):903-5. PMID: 11643033; PMCID: PMC1682818.
  138. Johnson K, Murphy CK, Beckwith J. Protein export in Escherichia coli. Curr Opin Biotechnol. 1992 Oct; 3(5):481-5. PMID: 1368933.
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  139. Billings PR, Beckwith J, Alper JS. The genetic analysis of human behavior: a new era? Soc Sci Med. 1992 Aug; 35(3):227-38. PMID: 1519075.
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  140. Billings P, Beckwith J. Genetic testing in the workplace: a view from the USA. Trends Genet. 1992 Jun; 8(6):198-202. PMID: 1496554.
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  141. Traxler B, Lee C, Boyd D, Beckwith J. The dynamics of assembly of a cytoplasmic membrane protein in Escherichia coli. J Biol Chem. 1992 Mar 15; 267(8):5339-45. PMID: 1544915.
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  143. Derman AI, Beckwith J. Escherichia coli alkaline phosphatase fails to acquire disulfide bonds when retained in the cytoplasm. J Bacteriol. 1991 Dec; 173(23):7719-22. PMID: 1938970; PMCID: PMC212545.
  144. McGovern K, Beckwith J. Membrane insertion of the Escherichia coli MalF protein in cells with impaired secretion machinery. J Biol Chem. 1991 Nov 05; 266(31):20870-6. PMID: 1939136.
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  145. Bardwell JC, McGovern K, Beckwith J. Identification of a protein required for disulfide bond formation in vivo. Cell. 1991 Nov 01; 67(3):581-9. PMID: 1934062.
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  146. McGovern K, Ehrmann M, Beckwith J. Decoding signals for membrane protein assembly using alkaline phosphatase fusions. EMBO J. 1991 Oct; 10(10):2773-82. PMID: 1915262; PMCID: PMC452986.
  147. Ehrmann M, Beckwith J. Proper insertion of a complex membrane protein in the absence of its amino-terminal export signal. J Biol Chem. 1991 Sep 05; 266(25):16530-3. PMID: 1885584.
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  148. Schatz PJ, Bieker KL, Ottemann KM, Silhavy TJ, Beckwith J. One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery. EMBO J. 1991 Jul; 10(7):1749-57. PMID: 2050112; PMCID: PMC452846.
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  150. Carson MJ, Barondess J, Beckwith J. The FtsQ protein of Escherichia coli: membrane topology, abundance, and cell division phenotypes due to overproduction and insertion mutations. J Bacteriol. 1991 Apr; 173(7):2187-95. PMID: 2007547; PMCID: PMC207766.
  151. Beckwith J. "Sequence-gazing?". Science. 1991 Mar 08; 251(4998):1161-2. PMID: 2006404.
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  152. Barondess JJ, Carson M, Guzman Verduzco LM, Beckwith J. Alkaline phosphatase fusions in the study of cell division genes. Res Microbiol. 1991 Feb-Apr; 142(2-3):295-9. PMID: 1656499.
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  153. Beckwith J. Foreword: the human genome initiative: genetics' lightning rod. Am J Law Med. 1991; 17(1-2):1-13. PMID: 1877606.
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  155. Gardel C, Johnson K, Jacq A, Beckwith J. The secD locus of E. coli codes for two membrane proteins required for protein export. EMBO J. 1990 Dec; 9(12):4205-6. PMID: 2249673; PMCID: PMC552197.
  156. Baba T, Jacq A, Brickman E, Beckwith J, Taura T, Ueguchi C, Akiyama Y, Ito K. Characterization of cold-sensitive secY mutants of Escherichia coli. J Bacteriol. 1990 Dec; 172(12):7005-10. PMID: 2254269; PMCID: PMC210821.
  157. Signer E, Beckwith J. Cloning with phi80lac: the French connection. Bioessays. 1990 Oct; 12(10):503-7. PMID: 2082941.
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  158. Ehrmann M, Boyd D, Beckwith J. Genetic analysis of membrane protein topology by a sandwich gene fusion approach. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7574-8. PMID: 2170984; PMCID: PMC54790.
  159. Gardel C, Johnson K, Jacq A, Beckwith J. The secD locus of E.coli codes for two membrane proteins required for protein export. EMBO J. 1990 Oct; 9(10):3209-16. PMID: 2170107; PMCID: PMC552051.
  160. Boyd D, Beckwith J. The role of charged amino acids in the localization of secreted and membrane proteins. Cell. 1990 Sep 21; 62(6):1031-3. PMID: 2205394.
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  161. Barondess JJ, Beckwith J. A bacterial virulence determinant encoded by lysogenic coliphage lambda. Nature. 1990 Aug 30; 346(6287):871-4. PMID: 2144037.
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  162. Manoil C, Mekalanos JJ, Beckwith J. Alkaline phosphatase fusions: sensors of subcellular location. J Bacteriol. 1990 Feb; 172(2):515-8. PMID: 2404939; PMCID: PMC208471.
  163. Schatz PJ, Beckwith J. Genetic analysis of protein export in Escherichia coli. Annu Rev Genet. 1990; 24:215-48. PMID: 2088168.
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  164. Boyd D, Beckwith J. Positively charged amino acid residues can act as topogenic determinants in membrane proteins. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9446-50. PMID: 2594779; PMCID: PMC298513.
  165. San Millan JL, Boyd D, Dalbey R, Wickner W, Beckwith J. Use of phoA fusions to study the topology of the Escherichia coli inner membrane protein leader peptidase. J Bacteriol. 1989 Oct; 171(10):5536-41. PMID: 2551889; PMCID: PMC210394.
  166. Lee C, Li P, Inouye H, Brickman ER, Beckwith J. Genetic studies on the inability of beta-galactosidase to be translocated across the Escherichia coli cytoplasmic membrane. J Bacteriol. 1989 Sep; 171(9):4609-16. PMID: 2527843; PMCID: PMC210258.
  167. Schatz PJ, Riggs PD, Jacq A, Fath MJ, Beckwith J. The secE gene encodes an integral membrane protein required for protein export in Escherichia coli. Genes Dev. 1989 Jul; 3(7):1035-44. PMID: 2673920.
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  168. Strauch KL, Johnson K, Beckwith J. Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature. J Bacteriol. 1989 May; 171(5):2689-96. PMID: 2540154; PMCID: PMC209953.
  169. Li P, Beckwith J, Inouye H. Alteration of the amino terminus of the mature sequence of a periplasmic protein can severely affect protein export in Escherichia coli. Proc Natl Acad Sci U S A. 1988 Oct; 85(20):7685-9. PMID: 3051001; PMCID: PMC282257.
  170. Manoil C, Boyd D, Beckwith J. Molecular genetic analysis of membrane protein topology. Trends Genet. 1988 Aug; 4(8):223-6. PMID: 3072723.
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  171. Froshauer S, Green GN, Boyd D, McGovern K, Beckwith J. Genetic analysis of the membrane insertion and topology of MalF, a cytoplasmic membrane protein of Escherichia coli. J Mol Biol. 1988 Apr 05; 200(3):501-11. PMID: 3294421.
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  172. Riggs PD, Derman AI, Beckwith J. A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene. Genetics. 1988 Apr; 118(4):571-9. PMID: 3284784; PMCID: PMC1203312.
  173. Strauch KL, Beckwith J. An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1576-80. PMID: 3278319; PMCID: PMC279816.
  174. Boyd D, Manoil C, Beckwith J. Determinants of membrane protein topology. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8525-9. PMID: 3317413; PMCID: PMC299577.
  175. Ebright RH, Kolb A, Buc H, Kunkel TA, Krakow JS, Beckwith J. Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6083-7. PMID: 2888111; PMCID: PMC299012.
  176. Gutierrez C, Barondess J, Manoil C, Beckwith J. The use of transposon TnphoA to detect genes for cell envelope proteins subject to a common regulatory stimulus. Analysis of osmotically regulated genes in Escherichia coli. J Mol Biol. 1987 May 20; 195(2):289-97. PMID: 2821274.
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  177. Boquet PL, Manoil C, Beckwith J. Use of TnphoA to detect genes for exported proteins in Escherichia coli: identification of the plasmid-encoded gene for a periplasmic acid phosphatase. J Bacteriol. 1987 Apr; 169(4):1663-9. PMID: 3031017; PMCID: PMC211997.
  178. Gardel C, Benson S, Hunt J, Michaelis S, Beckwith J. secD, a new gene involved in protein export in Escherichia coli. J Bacteriol. 1987 Mar; 169(3):1286-90. PMID: 3029032; PMCID: PMC211932.
  179. Lopilato J, Bortner S, Beckwith J. Mutations in a new chromosomal gene of Escherichia coli K-12, pcnB, reduce plasmid copy number of pBR322 and its derivatives. Mol Gen Genet. 1986 Nov; 205(2):285-90. PMID: 3100913.
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  180. Manoil C, Beckwith J. A genetic approach to analyzing membrane protein topology. Science. 1986 Sep 26; 233(4771):1403-8. PMID: 3529391.
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  181. Michaelis S, Hunt JF, Beckwith J. Effects of signal sequence mutations on the kinetics of alkaline phosphatase export to the periplasm in Escherichia coli. J Bacteriol. 1986 Jul; 167(1):160-7. PMID: 3522543; PMCID: PMC212855.
  182. Lee CA, Beckwith J. Suppression of growth and protein secretion defects in Escherichia coli secA mutants by decreasing protein synthesis. J Bacteriol. 1986 Jun; 166(3):878-83. PMID: 3519584; PMCID: PMC215208.
  183. Strauch KL, Kumamoto CA, Beckwith J. Does secA mediate coupling between secretion and translation in Escherichia coli? J Bacteriol. 1986 May; 166(2):505-12. PMID: 3009404; PMCID: PMC214633.
  184. Beckwith J, Ferro-Novick S. Genetic studies on protein export in bacteria. Curr Top Microbiol Immunol. 1986; 125:5-27. PMID: 3091324.
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  185. Lee C, Beckwith J. Cotranslational and posttranslational protein translocation in prokaryotic systems. Annu Rev Cell Biol. 1986; 2:315-36. PMID: 3548770.
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  186. Silhavy TJ, Beckwith JR. Uses of lac fusions for the study of biological problems. Microbiol Rev. 1985 Dec; 49(4):398-418. PMID: 3005818; PMCID: PMC373045.
  187. Manoil C, Beckwith J. TnphoA: a transposon probe for protein export signals. Proc Natl Acad Sci U S A. 1985 Dec; 82(23):8129-33. PMID: 2999794; PMCID: PMC391456.
  188. Kumamoto CA, Beckwith J. Evidence for specificity at an early step in protein export in Escherichia coli. J Bacteriol. 1985 Jul; 163(1):267-74. PMID: 3891730; PMCID: PMC219108.
  189. Lee CA, Fournier MJ, Beckwith J. Escherichia coli 6S RNA is not essential for growth or protein secretion. J Bacteriol. 1985 Mar; 161(3):1156-61. PMID: 2579059; PMCID: PMC215020.
  190. Ebright RH, Beckwith J. The catabolite gene activator protein (CAP) is not required for indole-3-acetic acid to activate transcription of the araBAD operon of Escherichia coli K-12. Mol Gen Genet. 1985; 201(1):51-5. PMID: 2997582.
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  191. Ebright RH, Cossart P, Gicquel-Sanzey B, Beckwith J. Molecular basis of DNA sequence recognition by the catabolite gene activator protein: detailed inferences from three mutations that alter DNA sequence specificity. Proc Natl Acad Sci U S A. 1984 Dec; 81(23):7274-8. PMID: 6390433; PMCID: PMC392128.
  192. Froshauer S, Beckwith J. The nucleotide sequence of the gene for malF protein, an inner membrane component of the maltose transport system of Escherichia coli. Repeated DNA sequences are found in the malE-malF intercistronic region. J Biol Chem. 1984 Sep 10; 259(17):10896-903. PMID: 6088520.
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  193. Ebright RH, Cossart P, Gicquel-Sanzey B, Beckwith J. Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli. Nature. 1984 Sep 20-26; 311(5983):232-5. PMID: 6090927.
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  194. Ferro-Novick S, Honma M, Beckwith J. The product of gene secC is involved in the synthesis of exported proteins in E. coli. Cell. 1984 Aug; 38(1):211-7. PMID: 6088066.
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  195. Lopilato JE, Garwin JL, Emr SD, Silhavy TJ, Beckwith JR. D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. J Bacteriol. 1984 May; 158(2):665-73. PMID: 6327616; PMCID: PMC215481.
  196. Kumamoto CA, Oliver DB, Beckwith J. Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli. Nature. 1984 Apr 26-May 2; 308(5962):863-4. PMID: 6371546.
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  197. Brickman ER, Oliver DB, Garwin JL, Kumamoto C, Beckwith J. The use of extragenic suppressors to define genes involved in protein export in Escherichia coli. Mol Gen Genet. 1984; 196(1):24-7. PMID: 6384729.
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  198. Michaelis S, Inouye H, Oliver D, Beckwith J. Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli. J Bacteriol. 1983 Apr; 154(1):366-74. PMID: 6339478; PMCID: PMC217468.
  199. Michaelis S, Guarente L, Beckwith J. In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli. J Bacteriol. 1983 Apr; 154(1):356-65. PMID: 6403507; PMCID: PMC217467.
  200. Kumamoto CA, Beckwith J. Mutations in a new gene, secB, cause defective protein localization in Escherichia coli. J Bacteriol. 1983 Apr; 154(1):253-60. PMID: 6403503; PMCID: PMC217454.
  201. Silhavy TJ, Beckwith J. Isolation and characterization of mutants of Escherichia coli K12 affected in protein localization. Methods Enzymol. 1983; 97:11-40. PMID: 6228708.
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  203. Oliver DB, Beckwith J. Regulation of a membrane component required for protein secretion in Escherichia coli. Cell. 1982 Aug; 30(1):311-9. PMID: 6751561.
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  205. Inouye H, Barnes W, Beckwith J. Signal sequence of alkaline phosphatase of Escherichia coli. J Bacteriol. 1982 Feb; 149(2):434-9. PMID: 7035431; PMCID: PMC216526.
  206. Garwin JL, Beckwith J. Secretion and processing of ribose-binding protein in Escherichia coli. J Bacteriol. 1982 Feb; 149(2):789-92. PMID: 7035438; PMCID: PMC216576.
  207. Oliver D, Kumamoto C, Quinlan M, Beckwith J. Pleiotropic mutants affecting the secretory apparatus of Escherichia coli. Ann Microbiol (Paris). 1982 Jan; 133A(1):105-10. PMID: 6803638.
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  208. Oliver DB, Beckwith J. E. coli mutant pleiotropically defective in the export of secreted proteins. Cell. 1981 Sep; 25(3):765-72. PMID: 7026050.
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  209. Ito K, Beckwith JR. Role of the mature protein sequence of maltose-binding protein in its secretion across the E. coli cytoplasmic membrane. Cell. 1981 Jul; 25(1):143-50. PMID: 7023692.
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  210. Ito K, Bassford PJ, Beckwith J. Protein localization in E. coli: is there a common step in the secretion of periplasmic and outer-membrane proteins? Cell. 1981 Jun; 24(3):707-17. PMID: 6788377.
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  211. Inouye H, Michaelis S, Wright A, Beckwith J. Cloning and restriction mapping of the alkaline phosphatase structural gene (phoA) of Escherichia coli and generation of deletion mutants in vitro. J Bacteriol. 1981 May; 146(2):668-75. PMID: 6260756; PMCID: PMC217011.
  212. Brown S, Brickman ER, Beckwith J. Blue ghosts: a new method for isolating amber mutants defective in essential genes of Escherichia coli. J Bacteriol. 1981 Apr; 146(1):422-5. PMID: 7012125; PMCID: PMC217102.
  213. Beckwith J. A genetic approach to characterizing complex promoters in E. coli. Cell. 1981 Feb; 23(2):307-8. PMID: 7008950.
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  214. Bassford PJ, Emr SD, Silhavy TJ, Beckwith J, Beduelle H, Clément JM, Hedgpeth J, Hofnung M. The genetics of protein secretion in Escherichia coli. Methods Cell Biol. 1981; 23:27-38. PMID: 7035805.
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  215. Sarthy A, Michaelis S, Beckwith J. Deletion map of the Escherichia coli structural gene for alkaline phosphatase, phoA. J Bacteriol. 1981 Jan; 145(1):288-92. PMID: 6450745; PMCID: PMC217271.
  216. Sarthy A, Michaelis S, Beckwith J. Use of gene fusions to determine the orientation of gene phoA on the Escherichia coli chromosome. J Bacteriol. 1981 Jan; 145(1):293-8. PMID: 7007316; PMCID: PMC217272.
  217. Bedouelle H, Bassford PJ, Fowler AV, Zabin I, Beckwith J, Hofnung M. Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli. Nature. 1980 May 08; 285(5760):78-81. PMID: 6990274.
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  218. Welply JK, Fowler AV, Beckwith JR, Zabin I. Positions of early nonsense and deletion mutations in lacZ. J Bacteriol. 1980 May; 142(2):732-4. PMID: 6769904; PMCID: PMC294065.
  219. Chang CN, Inouye H, Model P, Beckwith J. Processing of alkaline phosphatase precursor to the mature enzyme by an Escherichia coli inner membrane preparation. J Bacteriol. 1980 May; 142(2):726-8. PMID: 6991486; PMCID: PMC294062.
  220. Wu AM, Chapman AB, Platt T, Guarente LP, Beckwith J. Deletions of distal sequence after termination of transcription at the end of the tryptophan operon in E. coli. Cell. 1980 Apr; 19(4):829-36. PMID: 6991123.
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  221. Beckwith J. Industrial genetic screening. Sci People. 1980 Mar-Apr; 12(2):20-1. PMID: 11663067.
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  222. Shuman HA, Silhavy TJ, Beckwith JR. Labeling of proteins with beta-galactosidase by gene fusion. Identification of a cytoplasmic membrane component of the Escherichia coli maltose transport system. J Biol Chem. 1980 Jan 10; 255(1):168-74. PMID: 6765939.
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  223. Beckwith J, Fraenkel D. Luigi Gorini: November 13, 1903-August 13, 1976. Biogr Mem Natl Acad Sci. 1980; 52:203-21. PMID: 11620786.
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  224. Wanner BL, Sarthy A, Beckwith J. Escherichia coli pleiotropic mutant that reduces amounts of several periplasmic and outer membrane proteins. J Bacteriol. 1979 Oct; 140(1):229-39. PMID: 387722; PMCID: PMC216800.
  225. Sarthy A, Fowler A, Zabin I, Beckwith J. Use of gene fusions to determine a partial signal sequence of alkaline phosphatase. J Bacteriol. 1979 Sep; 139(3):932-9. PMID: 113391; PMCID: PMC218041.
  226. Silhavy TJ, Brickman E, Bassford PJ, Casadaban MJ, Shuman HA, Schwartz V, Guarente L, Schwartz M, Beckwith JR. Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE,F,G operon. Mol Gen Genet. 1979 Jul 24; 174(3):249-59. PMID: 384167.
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  227. Brickman E, Silhavy TJ, Bassford PJ, Shuman HA, Beckwith JR. Sites within gene lacZ of Escherichia coli for formation of active hybrid beta-galactosidase molecules. J Bacteriol. 1979 Jul; 139(1):13-8. PMID: 110776; PMCID: PMC216821.
  228. Bassford PJ, Silhavy TJ, Beckwith JR. Use of gene fusion to study secretion of maltose-binding protein into Escherichia coli periplasm. J Bacteriol. 1979 Jul; 139(1):19-31. PMID: 110778; PMCID: PMC216822.
  229. Berman ML, Beckwith J. Use of gene fusions to isolate promoter mutants in the transfer RNA gene tyrT of Escherichia coli. J Mol Biol. 1979 May 25; 130(3):303-15. PMID: 381676.
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  230. Berman ML, Beckwith J. Fusions of the lac operon to the transfer RNA gene tyrT of Escherichia coli. J Mol Biol. 1979 May 25; 130(3):285-301. PMID: 381675.
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  231. Bassford P, Beckwith J. Escherichia coli mutants accumulating the precursor of a secreted protein in the cytoplasm. Nature. 1979 Feb 15; 277(5697):538-41. PMID: 368649.
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  232. Bergman K, Beckwith J. Human genetic engineering: a social and political perspective. Biochem Soc Symp. 1979; 44:133-40. PMID: 291434.
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  233. Shuman HA, Beckwith J. Escherichia coli K-12 mutants that allow transport of maltose via the beta-galactoside transport system. J Bacteriol. 1979 Jan; 137(1):365-73. PMID: 368019; PMCID: PMC218459.
  234. Schneider S, Loechler E, King J, Beckwith J. Science for the people. Nature. 1978 Aug 24; 274(5673):732. PMID: 683313.
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  235. Zabin I, Fowler AV, Beckwith JR. Position of the mutation in beta-galactosidase ochre mutant U118. J Bacteriol. 1978 Jan; 133(1):437-8. PMID: 412841; PMCID: PMC222035.
  236. Guarente LP, Beckwith J. Mutant RNA polymerase of Escherichia coli terminates transcription in strains making defective rho factor. Proc Natl Acad Sci U S A. 1978 Jan; 75(1):294-7. PMID: 343107; PMCID: PMC411233.
  237. Silhavy TJ, Shuman HA, Beckwith J, Schwartz M. Use of gene fusions to study outer membrane protein localization in Escherichia coli. Proc Natl Acad Sci U S A. 1977 Dec; 74(12):5411-5. PMID: 414221; PMCID: PMC431741.
  238. Guarente LP, Mitchell DH, Beckwith J. Transcription termination at the end of the tryptophan operon of Escherichia coli. J Mol Biol. 1977 May 25; 112(3):423-36. PMID: 327077.
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  239. Beckwith J. Recombinant DNA: does the fault lie within our genes? Sci People. 1977 May-Jun; 9(3):14-7. PMID: 11662383.
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  240. Inouye H, Beckwith J. Synthesis and processing of an Escherichia coli alkaline phosphatase precursor in vitro. Proc Natl Acad Sci U S A. 1977 Apr; 74(4):1440-4. PMID: 323853; PMCID: PMC430790.
  241. Inouye H, Pratt C, Beckwith J, Torriani A. Alkaline phosphatase synthesis in a cell-free system using DNA and RNA templates. J Mol Biol. 1977 Feb 15; 110(1):75-87. PMID: 845948.
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  242. Beckwith J, Miller L. The XYY male: the making of a myth. Harv Mag. 1976 Oct; 79(2):30-3. PMID: 11662892.
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  243. Silhavy TJ, Casadaban MJ, Shuman HA, Beckwith JR. Conversion of beta-galactosidase to a membrane-bound state by gene fusion. Proc Natl Acad Sci U S A. 1976 Oct; 73(10):3423-7. PMID: 790385; PMCID: PMC431127.
  244. Mitchell DH, Reznikoff WS, Beckwith J. Genetic fusions that help define a transcription termination region in Escherichia coli. J Mol Biol. 1976 Mar 15; 101(4):441-57. PMID: 772220.
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  245. Beckwith J. Social and political uses of genetics in the United States: past and present. Ann N Y Acad Sci. 1976; 265:46-58. PMID: 782319.
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  246. Pyeritz R, Beckwith J, Miller L. Letter: XYY disclosure condemned. N Engl J Med. 1975 Sep 04; 293(10):508. PMID: 1152871.
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  247. Brickman E, Beckwith J. Analysis of the regulation of Escherichia coli alkaline phosphatase synthesis using deletions and phi80 transducing phages. J Mol Biol. 1975 Aug 05; 96(2):307-16. PMID: 1100846.
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  248. Mitchell DH, Reznikoff WS, Beckwith JR. Genetic fusions defining trp and lac operon regulatory elements. J Mol Biol. 1975 Apr 15; 93(3):331-50. PMID: 1095760.
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  249. Sabourin D, Beckwith J. Deletion of the Escherichia coli crp gene. J Bacteriol. 1975 Apr; 122(1):338-40. PMID: 164435; PMCID: PMC235677.
  250. Beckwith Je, et al. Harvard XYY study. Science. 1975 Jan 31; 187(4174):298-9. PMID: 11643259.
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  251. Beckwith J, King J. The XYY syndrome: a dangerous myth. New Sci. 1974 Nov 14; 64(923):474-6. PMID: 11664346.
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  252. Ausubel F, Beckwith J, Janssen K. The politics of genetic engineering: who decides who's defective? Psychol Today. 1974 Jun; 8(1):30+. PMID: 11662940.
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  253. Beckwith J, Rossow P. Analysis of genetic regulatory mechanisms. Annu Rev Genet. 1974; 8:1-13. PMID: 4613253.
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  254. Brickman E, Soll L, Beckwith J. Genetic characterization of mutations which affect catabolite-sensitive operons in Escherichia coli, including deletions of the gene for adenyl cyclase. J Bacteriol. 1973 Nov; 116(2):582-7. PMID: 4583241; PMCID: PMC285421.
  255. Arditti R, Grodzicker T, Beckwith J. Cyclic adenosine monophosphate-independent mutants of the lactose operon of Escherichia coli. J Bacteriol. 1973 May; 114(2):652-5. PMID: 4350344; PMCID: PMC251822.
  256. Beckwith J, Grodzicker T, Arditti R. Evidence for two sites in the lac promoter region. J Mol Biol. 1972 Aug 14; 69(1):155-60. PMID: 4341750.
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  257. Beckwith J. Science for the people. Ann N Y Acad Sci. 1972; 196(4):236-40. PMID: 4504114.
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  258. Ippen K, Shapiro JA, Beckwith JR. Transposition of the lac region to the gal region of the Escherichia coli chromosome: isolation of lambda-lac transducing bacteriophages. J Bacteriol. 1971 Oct; 108(1):5-9. PMID: 4941573; PMCID: PMC247025.
  259. Eron L, Morse D, Reznikoff W, Beckwith J. Fusions of the lac and trp regions of escherichia coli: covalently fused messenger RNA. J Mol Biol. 1971 Aug 28; 60(1):203-9. PMID: 4937192.
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  260. Eron L, Arditti R, Zubay G, Connaway S, Beckwith JR. An adenosine 3':5'-cyclic monophosphate-binding protein that acts on the transcription process. Proc Natl Acad Sci U S A. 1971 Jan; 68(1):215-8. PMID: 4322261; PMCID: PMC391198.
  261. Miller JH, Reznikoff WS, Silverstone AE, Ippen K, Signer ER, Beckwith JR. Fusions of the lac and trp Regions of the Escherichia coli Chromosome. J Bacteriol. 1970 Dec; 104(3):1273-9. PMID: 16559103.
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  262. Beckwith JR. Gene expression in bacteria and some concerns about the misuse of science. Bacteriol Rev. 1970 Sep; 34(3):222-7. PMID: 4918523; PMCID: PMC378355.
  263. Zubay G, Schwartz D, Beckwith J. Mechanism of activation of catabolite-sensitive genes: a positive control system. Proc Natl Acad Sci U S A. 1970 May; 66(1):104-10. PMID: 4320461; PMCID: PMC286094.
  264. Shapiro J, Machattie L, Eron L, Ihler G, Ippen K, Beckwith J. Isolation of pure lac operon DNA. Nature. 1969 Nov 22; 224(5221):768-74. PMID: 4902927.
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  265. Gottesman S, Beckwith JR. Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene. J Mol Biol. 1969 Aug 28; 44(1):117-27. PMID: 4897798.
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  266. Reznikoff WS, Beckwith JR. Genetic evidence that the operator locus is distinct from the the z gene in the lac operon of Escherichia coli. J Mol Biol. 1969 Jul 14; 43(1):215-8. PMID: 4897792.
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  267. Reznikoff WS, Miller JH, Scaife JG, Beckwith JR. A mechanism for repressor action. J Mol Biol. 1969 Jul 14; 43(1):201-13. PMID: 4897791.
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  268. Silverstone AE, Magasanik B, Reznikoff WS, Miller JH, Beckwith JR. Catabolite sensitive site of the lac operon. Nature. 1969 Mar 15; 221(5185):1012-4. PMID: 4886742.
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  269. Schwartz DO, Beckwith JR. Mutagens which cause deletions in Escherichia coli. Genetics. 1969 Feb; 61(2):371-6. PMID: 4896998; PMCID: PMC1212162.
  270. Miller JH, Beckwith J, Muller-Hill B. Direction of transcription of a regulatory gene in E. coli. Nature. 1968 Dec 28; 220(5174):1287-90. PMID: 4882916.
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  271. Arditti RR, Scaife JG, Beckwith JR. The nature of mutants in the lac promoter region. J Mol Biol. 1968 Dec; 38(3):421-6. PMID: 4887878.
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  272. Miller JH, Ippen K, Scaife JG, Beckwith JR. The promoter-operator region of the lac operon of Escherichia coli. J Mol Biol. 1968 Dec; 38(3):413-20. PMID: 4887877.
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  273. Ohlsson BM, Strigini PF, Beckwith JR. Allelic amber and ochre suppressors. J Mol Biol. 1968 Sep 14; 36(2):209-18. PMID: 5760539.
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  274. Ippen K, Miller JH, Scaife J, Beckwith J. New controlling element in the Lac operon of E. coli. Nature. 1968 Mar 02; 217(5131):825-7. PMID: 4867974.
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  275. Beckwith JR. Regulation of the lac operon. Recent studies on the regulation of lactose metabolism in Escherichia coli support the operon model. Science. 1967 May 05; 156(3775):597-604. PMID: 5337175.
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  276. Beckwith JR, Signer ER. Transposition of the lac region of Escherichia coli. I. Inversion of the lac operon and transduction of lac by phi80. J Mol Biol. 1966 Aug; 19(2):254-65. PMID: 5338856.
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  277. Fox CF, Beckwith JR, Epstein W, Signer ER. Transposition of the lac region of Escherichia coli. II. On the role of thiogalactoside transacetylase in lactose metabolism. J Mol Biol. 1966 Aug; 19(2):576-9. PMID: 5338859.
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  278. Beckwith JR, Signer ER, Epstein W. Transposition of the Lac region of E. coli. Cold Spring Harb Symp Quant Biol. 1966; 31:393-401. PMID: 4866389.
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  279. Gorini L, Beckwith JR. Suppression. Annu Rev Microbiol. 1966; 20:401-22. PMID: 5330239.
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  280. Scaife J, Beckwith JR. Mutational alteration of the maximal level of Lac operon expression. Cold Spring Harb Symp Quant Biol. 1966; 31:403-8. PMID: 4866390.
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  281. Signer ER, Beckwith JR, Brenner S. Mapping of suppressor loci in Escherichia coli. J Mol Biol. 1965 Nov; 14(1):153-66. PMID: 5327649.
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  282. Newton WA, Beckwith JR, Zipser D, Brenner S. Nonsense mutants and polarity in the lac operon of Escherichia coli. J Mol Biol. 1965 Nov; 14(1):290-6. PMID: 5327654.
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  283. TAYLOR AL, BECKWITH JR, PARDEE AB, AUSTRIAN R, JACOB F. THE CHROMOSOMAL LOCATION OF THE STRUCTURAL GENE FOR OROTIDYLIC ACID PYROPHOSPHORYLASE IN ESCHERICHIA COLI. J Mol Biol. 1964 May; 8:771. PMID: 14187401.
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  284. BECKWITH JR. A DELETION ANALYSIS OF THE LAC OPERATOR REGION IN ESCHERICHIA COLI. J Mol Biol. 1964 Mar; 8:427-30. PMID: 14168696.
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  285. BECKWITH JR, PARDEE AB, AUSTRIAN R, JACOB F. Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli. J Mol Biol. 1962 Dec; 5:618-34. PMID: 13970180.
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