Harvard Catalyst Profiles

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Jonathan Roger Beckwith, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03TW006003 (BECKWITH, JONATHAN R) Jul 1, 2002 - Jun 30, 2004
    NIH/FIC
    Characterization of the bacterial Arc system.
    Role: Principal Investigator
  2. R01GM055090 (BECKWITH, JONATHAN) Feb 1, 1998 - Jan 31, 2011
    NIH/NIGMS
    Disulfide Bond Formation: Mechanisms for Isomerization and Novel Pathways
    Role: Principal Investigator
  3. R01GM041883 (BOYD, DANA) Jun 1, 1989 - Feb 28, 2015
    NIH/NIGMS
    Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
    Role: Co-Principal Investigator
  4. R01GM038922 (BECKWITH, JONATHAN) Sep 1, 1987 - Feb 28, 2007
    NIH/NIGMS
    MEMBRANE PROTEINS INVOLVED IN CELL DIVISION IN E.COLI
    Role: Principal Investigator
  5. R37GM038922 (BECKWITH, JONATHAN R) Sep 1, 1987 - Aug 31, 1997
    NIH/NIGMS
    INSERTION AND TOPOLOGY OF MEMBRANE PROTEINS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gonzalez MD, Akbay EA, Boyd D, Beckwith J. Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex. J Bacteriol. 2010 Jun; 192(11):2757-68. PMID: 20363951.
    Citations: 17     Fields:    Translation:Cells
  2. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12. PMID: 20110994.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  3. Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):297-301. PMID: 20018758.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  4. Chung HS, Yao Z, Goehring NW, Kishony R, Beckwith J, Kahne D. Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21872-7. PMID: 19995973.
    Citations: 26     Fields:    
  5. Shouldice SR, Cho SH, Boyd D, Heras B, Eser M, Beckwith J, Riggs P, Martin JL, Berkmen M. In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling. Mol Microbiol. 2010 Jan; 75(1):13-28. PMID: 19968787.
    Citations: 17     Fields:    Translation:Cells
  6. Kadokura H, Beckwith J. Detecting folding intermediates of a protein as it passes through the bacterial translocation channel. Cell. 2009 Sep 18; 138(6):1164-73. PMID: 19766568.
    Citations: 43     Fields:    Translation:Cells
  7. Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Gaucher E, Sanchez-Ruiz JM, Berne BJ, Fernandez JM. Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy. Nat Struct Mol Biol. 2009 Aug; 16(8):890-6. PMID: 19597482.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  8. Cho SH, Beckwith J. Two snapshots of electron transport across the membrane: insights into the structure and function of DsbD. J Biol Chem. 2009 Apr 24; 284(17):11416-24. PMID: 19258316.
    Citations: 13     Fields:    Translation:Cells
  9. Gonzalez MD, Beckwith J. Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins. J Bacteriol. 2009 Apr; 191(8):2815-25. PMID: 19233928.
    Citations: 23     Fields:    Translation:Cells
  10. Beckwith J. Genetic suppressors and recovery of repressed biochemical memory. J Biol Chem. 2009 May 08; 284(19):12585-92. PMID: 19129182.
    Citations: 4     Fields:    Translation:HumansCells
  11. Zhou Y, Cierpicki T, Jimenez RH, Lukasik SM, Ellena JF, Cafiso DS, Kadokura H, Beckwith J, Bushweller JH. NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol Cell. 2008 Sep 26; 31(6):896-908. PMID: 18922471.
    Citations: 79     Fields:    Translation:Cells
  12. Dutton RJ, Boyd D, Berkmen M, Beckwith J. Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11933-8. PMID: 18695247.
    Citations: 90     Fields:    Translation:Cells
  13. Robichon C, King GF, Goehring NW, Beckwith J. Artificial septal targeting of Bacillus subtilis cell division proteins in Escherichia coli: an interspecies approach to the study of protein-protein interactions in multiprotein complexes. J Bacteriol. 2008 Sep; 190(18):6048-59. PMID: 18621900.
    Citations: 12     Fields:    Translation:Cells
  14. Faulkner MJ, Veeravalli K, Gon S, Georgiou G, Beckwith J. Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways. Proc Natl Acad Sci U S A. 2008 May 06; 105(18):6735-40. PMID: 18456836.
    Citations: 18     Fields:    Translation:Cells
  15. Yamamoto Y, Ritz D, Planson AG, Jönsson TJ, Faulkner MJ, Boyd D, Beckwith J, Poole LB. Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity. Mol Cell. 2008 Jan 18; 29(1):36-45. PMID: 18206967.
    Citations: 15     Fields:    Translation:Cells
  16. Ye J, Cho SH, Fuselier J, Li W, Beckwith J, Rapoport TA. Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem. 2007 Nov 30; 282(48):34945-51. PMID: 17913712.
    Citations: 6     Fields:    Translation:Cells
  17. Scheffers DJ, Robichon C, Haan GJ, den Blaauwen T, Koningstein G, van Bloois E, Beckwith J, Luirink J. Contribution of the FtsQ transmembrane segment to localization to the cell division site. J Bacteriol. 2007 Oct; 189(20):7273-80. PMID: 17693520.
    Citations: 10     Fields:    Translation:Cells
  18. Cho SH, Porat A, Ye J, Beckwith J. Redox-active cysteines of a membrane electron transporter DsbD show dual compartment accessibility. EMBO J. 2007 Aug 08; 26(15):3509-20. PMID: 17641688.
    Citations: 16     Fields:    Translation:Cells
  19. Beckwith J. What lies beyond uranus? Preconceptions, ignorance, serendipity and suppressors in the search for biology's secrets. Genetics. 2007 Jun; 176(2):733-40. PMID: 17579239.
    Citations:    Fields:    Translation:Cells
  20. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21. PMID: 17531810.
    Citations: 41     Fields:    Translation:Cells
  21. Porat A, Lillig CH, Johansson C, Fernandes AP, Nilsson L, Holmgren A, Beckwith J. The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43. Biochemistry. 2007 Mar 20; 46(11):3366-77. PMID: 17305371.
    Citations: 2     Fields:    Translation:Cells
  22. Goehring NW, Robichon C, Beckwith J. Role for the nonessential N terminus of FtsN in divisome assembly. J Bacteriol. 2007 Jan; 189(2):646-9. PMID: 17071748.
    Citations: 17     Fields:    Translation:Cells
  23. Goehring NW, Petrovska I, Boyd D, Beckwith J. Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly. J Bacteriol. 2007 Jan; 189(2):633-45. PMID: 16980443.
    Citations: 23     Fields:    Translation:Cells
  24. Goehring NW, Gonzalez MD, Beckwith J. Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly. Mol Microbiol. 2006 Jul; 61(1):33-45. PMID: 16824093.
    Citations: 58     Fields:    Translation:Cells
  25. Cho SH, Beckwith J. Mutations of the membrane-bound disulfide reductase DsbD that block electron transfer steps from cytoplasm to periplasm in Escherichia coli. J Bacteriol. 2006 Jul; 188(14):5066-76. PMID: 16816179.
    Citations: 7     Fields:    Translation:Cells
  26. Gon S, Faulkner MJ, Beckwith J. In vivo requirement for glutaredoxins and thioredoxins in the reduction of the ribonucleotide reductases of Escherichia coli. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):735-42. PMID: 16771665.
    Citations: 26     Fields:    Translation:Cells
  27. Gon S, Beckwith J. Ribonucleotide reductases: influence of environment on synthesis and activity. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):773-80. PMID: 16771669.
    Citations: 14     Fields:    Translation:Cells
  28. Gon S, Camara JE, Klungsøyr HK, Crooke E, Skarstad K, Beckwith J. A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli. EMBO J. 2006 Mar 08; 25(5):1137-47. PMID: 16482221.
    Citations: 59     Fields:    Translation:Cells
  29. Huber D, Cha MI, Debarbieux L, Planson AG, Cruz N, López G, Tasayco ML, Chaffotte A, Beckwith J. A selection for mutants that interfere with folding of Escherichia coli thioredoxin-1 in vivo. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18872-7. PMID: 16357193.
    Citations: 14     Fields:    Translation:Cells
  30. Beckwith J, Huang F. Should we make a fuss? A case for social responsibility in science. Nat Biotechnol. 2005 Dec; 23(12):1479-80. PMID: 16333283.
    Citations: 8     Fields:    
  31. Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. J Biol Chem. 2006 Feb 24; 281(8):4911-9. PMID: 16280324.
    Citations: 15     Fields:    Translation:Cells
  32. Goehring NW, Beckwith J. Diverse paths to midcell: assembly of the bacterial cell division machinery. Curr Biol. 2005 Jul 12; 15(13):R514-26. PMID: 16005287.
    Citations: 167     Fields:    Translation:Cells
  33. Sevier CS, Kadokura H, Tam VC, Beckwith J, Fass D, Kaiser CA. The prokaryotic enzyme DsbB may share key structural features with eukaryotic disulfide bond forming oxidoreductases. Protein Sci. 2005 Jun; 14(6):1630-42. PMID: 15930008.
    Citations: 11     Fields:    Translation:Cells
  34. Huber D, Boyd D, Xia Y, Olma MH, Gerstein M, Beckwith J. Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition particle-dependent translocation. J Bacteriol. 2005 May; 187(9):2983-91. PMID: 15838024.
    Citations: 48     Fields:    Translation:Cells
  35. Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N. An open letter to Elias Zerhouni. Science. 2005 Mar 04; 307(5714):1409-10. PMID: 15746409.
    Citations: 1     Fields:    Translation:PHPublic Health
  36. Kadokura H, Nichols L, Beckwith J. Mutational alterations of the key cis proline residue that cause accumulation of enzymatic reaction intermediates of DsbA, a member of the thioredoxin superfamily. J Bacteriol. 2005 Feb; 187(4):1519-22. PMID: 15687218.
    Citations: 9     Fields:    Translation:Cells
  37. Berkmen M, Boyd D, Beckwith J. The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC. J Biol Chem. 2005 Mar 25; 280(12):11387-94. PMID: 15642731.
    Citations: 43     Fields:    Translation:Cells
  38. Goehring NW, Gueiros-Filho F, Beckwith J. Premature targeting of a cell division protein to midcell allows dissection of divisome assembly in Escherichia coli. Genes Dev. 2005 Jan 01; 19(1):127-37. PMID: 15630023.
    Citations: 41     Fields:    Translation:Cells
  39. Or E, Boyd D, Gon S, Beckwith J, Rapoport T. The bacterial ATPase SecA functions as a monomer in protein translocation. J Biol Chem. 2005 Mar 11; 280(10):9097-105. PMID: 15618215.
    Citations: 38     Fields:    Translation:Cells
  40. Porat A, Cho SH, Beckwith J. The unusual transmembrane electron transporter DsbD and its homologues: a bacterial family of disulfide reductases. Res Microbiol. 2004 Oct; 155(8):617-22. PMID: 15380548.
    Citations: 12     Fields:    Translation:Cells
  41. Buddelmeijer N, Beckwith J. A complex of the Escherichia coli cell division proteins FtsL, FtsB and FtsQ forms independently of its localization to the septal region. Mol Microbiol. 2004 Jun; 52(5):1315-27. PMID: 15165235.
    Citations: 62     Fields:    Translation:Cells
  42. Ortenberg R, Gon S, Porat A, Beckwith J. Interactions of glutaredoxins, ribonucleotide reductase, and components of the DNA replication system of Escherichia coli. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7439-44. PMID: 15123823.
    Citations: 32     Fields:    Translation:Cells
  43. Kadokura H, Tian H, Zander T, Bardwell JC, Beckwith J. Snapshots of DsbA in action: detection of proteins in the process of oxidative folding. Science. 2004 Jan 23; 303(5657):534-7. PMID: 14739460.
    Citations: 80     Fields:    Translation:Cells
  44. Belin D, Guzman LM, Bost S, Konakova M, Silva F, Beckwith J. Functional activity of eukaryotic signal sequences in Escherichia coli: the ovalbumin family of serine protease inhibitors. J Mol Biol. 2004 Jan 09; 335(2):437-53. PMID: 14672654.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  45. Beckwith J. An active life in science. Interview by Holger Breithaupt and Caroline Hadley. EMBO Rep. 2004 Jan; 5(1):12-5. PMID: 14710176.
    Citations:    Fields:    
  46. Schierle CF, Berkmen M, Huber D, Kumamoto C, Boyd D, Beckwith J. The DsbA signal sequence directs efficient, cotranslational export of passenger proteins to the Escherichia coli periplasm via the signal recognition particle pathway. J Bacteriol. 2003 Oct; 185(19):5706-13. PMID: 13129941.
    Citations: 71     Fields:    Translation:Cells
  47. Brandon LD, Goehring N, Janakiraman A, Yan AW, Wu T, Beckwith J, Goldberg MB. IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributed. Mol Microbiol. 2003 Oct; 50(1):45-60. PMID: 14507362.
    Citations: 46     Fields:    Translation:Cells
  48. Katzen F, Beckwith J. Role and location of the unusual redox-active cysteines in the hydrophobic domain of the transmembrane electron transporter DsbD. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10471-6. PMID: 12925743.
    Citations: 12     Fields:    Translation:Cells
  49. Ortenberg R, Beckwith J. Functions of thiol-disulfide oxidoreductases in E. coli: redox myths, realities, and practicalities. Antioxid Redox Signal. 2003 Aug; 5(4):403-11. PMID: 13678528.
    Citations: 12     Fields:    Translation:Cells
  50. Toutain CM, Clarke DJ, Leeds JA, Kuhn J, Beckwith J, Holland IB, Jacq A. The transmembrane domain of the DnaJ-like protein DjlA is a dimerisation domain. Mol Genet Genomics. 2003 Mar; 268(6):761-70. PMID: 12655402.
    Citations: 4     Fields:    Translation:Cells
  51. Kadokura H, Katzen F, Beckwith J. Protein disulfide bond formation in prokaryotes. Annu Rev Biochem. 2003; 72:111-35. PMID: 12524212.
    Citations: 152     Fields:    Translation:Cells
  52. Buddelmeijer N, Beckwith J. Assembly of cell division proteins at the E. coli cell center. Curr Opin Microbiol. 2002 Dec; 5(6):553-7. PMID: 12457697.
    Citations: 49     Fields:    Translation:Cells
  53. Haebel PW, Goldstone D, Katzen F, Beckwith J, Metcalf P. The disulfide bond isomerase DsbC is activated by an immunoglobulin-fold thiol oxidoreductase: crystal structure of the DsbC-DsbDalpha complex. EMBO J. 2002 Sep 16; 21(18):4774-84. PMID: 12234918.
    Citations: 32     Fields:    Translation:Cells
  54. Katzen F, Deshmukh M, Daldal F, Beckwith J. Evolutionary domain fusion expanded the substrate specificity of the transmembrane electron transporter DsbD. EMBO J. 2002 Aug 01; 21(15):3960-9. PMID: 12145197.
    Citations: 26     Fields:    Translation:Cells
  55. Jurado P, Ritz D, Beckwith J, de Lorenzo V, Fernández LA. Production of functional single-chain Fv antibodies in the cytoplasm of Escherichia coli. J Mol Biol. 2002 Jun 28; 320(1):1-10. PMID: 12079330.
    Citations: 42     Fields:    Translation:Cells
  56. Kadokura H, Beckwith J. Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA. EMBO J. 2002 May 15; 21(10):2354-63. PMID: 12006488.
    Citations: 37     Fields:    Translation:Cells
  57. Buddelmeijer N, Judson N, Boyd D, Mekalanos JJ, Beckwith J. YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6316-21. PMID: 11972052.
    Citations: 36     Fields:    Translation:Cells
  58. Chen JC, Minev M, Beckwith J. Analysis of ftsQ mutant alleles in Escherichia coli: complementation, septal localization, and recruitment of downstream cell division proteins. J Bacteriol. 2002 Feb; 184(3):695-705. PMID: 11790739.
    Citations: 26     Fields:    Translation:Cells
  59. Ritz D, Beckwith J. Redox state of cytoplasmic thioredoxin. Methods Enzymol. 2002; 347:360-70. PMID: 11898427.
    Citations: 7     Fields:    Translation:Cells
  60. Katzen F, Beckwith J. Disulfide bond formation in periplasm of Escherichia coli. Methods Enzymol. 2002; 348:54-66. PMID: 11885294.
    Citations: 3     Fields:    Translation:Cells
  61. Tian H, Beckwith J. Genetic screen yields mutations in genes encoding all known components of the Escherichia coli signal recognition particle pathway. J Bacteriol. 2002 Jan; 184(1):111-8. PMID: 11741850.
    Citations: 20     Fields:    Translation:Cells
  62. Kadokura H, Beckwith J. The expanding world of oxidative protein folding. Nat Cell Biol. 2001 Nov; 3(11):E247-9. PMID: 11715032.
    Citations: 5     Fields:    Translation:AnimalsCells
  63. Leeds JA, Boyd D, Huber DR, Sonoda GK, Luu HT, Engelman DM, Beckwith J. Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library. J Mol Biol. 2001 Oct 12; 313(1):181-95. PMID: 11601855.
    Citations: 7     Fields:    Translation:Cells
  64. Ritz D, Lim J, Reynolds CM, Poole LB, Beckwith J. Conversion of a peroxiredoxin into a disulfide reductase by a triplet repeat expansion. Science. 2001 Oct 05; 294(5540):158-60. PMID: 11588261.
    Citations: 31     Fields:    Translation:Cells
  65. Chen JC, Beckwith J. FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division. Mol Microbiol. 2001 Oct; 42(2):395-413. PMID: 11703663.
    Citations: 74     Fields:    Translation:Cells
  66. Goldstone D, Haebel PW, Katzen F, Bader MW, Bardwell JC, Beckwith J, Metcalf P. DsbC activation by the N-terminal domain of DsbD. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9551-6. PMID: 11493705.
    Citations: 7     Fields:    Translation:Cells
  67. Beckwith J. On the social responsibility of scientists. Ann Ist Super Sanita. 2001; 37(2):189-94. PMID: 11758276.
    Citations:    Fields:    Translation:Humans
  68. Ritz D, Beckwith J. Roles of thiol-redox pathways in bacteria. Annu Rev Microbiol. 2001; 55:21-48. PMID: 11544348.
    Citations: 94     Fields:    Translation:Cells
  69. Katzen F, Beckwith J. Transmembrane electron transfer by the membrane protein DsbD occurs via a disulfide bond cascade. Cell. 2000 Nov 22; 103(5):769-79. PMID: 11114333.
    Citations: 59     Fields:    Translation:Cells
  70. Kadokura H, Bader M, Tian H, Bardwell JC, Beckwith J. Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10884-9. PMID: 11005861.
    Citations: 25     Fields:    Translation:Cells
  71. Alper JS, Beckwith J. On the philosophical analysis of genetic essentialism. Commentary on: "The use of genetic test information in insurance: the argument from indistinguishability reconsidered". Sci Eng Ethics. 2000 Jul; 6(3):311-4. PMID: 11273457.
    Citations:    Fields:    Translation:Humans
  72. Tian H, Boyd D, Beckwith J. A mutant hunt for defects in membrane protein assembly yields mutations affecting the bacterial signal recognition particle and Sec machinery. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4730-5. PMID: 10781078.
    Citations: 35     Fields:    Translation:Cells
  73. Boyd D, Weiss DS, Chen JC, Beckwith J. Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda InCh, a simple Escherichia coli plasmid-chromosome shuttle system. J Bacteriol. 2000 Feb; 182(3):842-7. PMID: 10633125.
    Citations: 86     Fields:    Translation:Cells
  74. Debarbieux L, Beckwith J. On the functional interchangeability, oxidant versus reductant, of members of the thioredoxin superfamily. J Bacteriol. 2000 Feb; 182(3):723-7. PMID: 10633106.
    Citations: 16     Fields:    Translation:Cells
  75. Ritz D, Patel H, Doan B, Zheng M, Aslund F, Storz G, Beckwith J. Thioredoxin 2 is involved in the oxidative stress response in Escherichia coli. J Biol Chem. 2000 Jan 28; 275(4):2505-12. PMID: 10644706.
    Citations: 40     Fields:    Translation:Cells
  76. Ghigo JM, Beckwith J. Cell division in Escherichia coli: role of FtsL domains in septal localization, function, and oligomerization. J Bacteriol. 2000 Jan; 182(1):116-29. PMID: 10613870.
    Citations: 19     Fields:    Translation:Cells
  77. Leeds JA, Beckwith J. A gene fusion method for assaying interactions of protein transmembrane segments in vivo. Methods Enzymol. 2000; 327:165-75. PMID: 11044981.
    Citations: 1     Fields:    Translation:Cells
  78. Beckwith J. The all purpose gene fusion. Methods Enzymol. 2000; 326:3-7. PMID: 11036631.
    Citations: 3     Fields:    
  79. Bessette PH, Aslund F, Beckwith J, Georgiou G. Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13703-8. PMID: 10570136.
    Citations: 141     Fields:    Translation:AnimalsCells
  80. Stewart EJ, Katzen F, Beckwith J. Six conserved cysteines of the membrane protein DsbD are required for the transfer of electrons from the cytoplasm to the periplasm of Escherichia coli. EMBO J. 1999 Nov 01; 18(21):5963-71. PMID: 10545108.
    Citations: 46     Fields:    Translation:Cells
  81. Debarbieux L, Beckwith J. Electron avenue: pathways of disulfide bond formation and isomerization. Cell. 1999 Oct 15; 99(2):117-9. PMID: 10535729.
    Citations: 17     Fields:    Translation:Cells
  82. Mössner E, Huber-Wunderlich M, Rietsch A, Beckwith J, Glockshuber R, Aslund F. Importance of redox potential for the in vivo function of the cytoplasmic disulfide reductant thioredoxin from Escherichia coli. J Biol Chem. 1999 Sep 03; 274(36):25254-9. PMID: 10464247.
    Citations: 21     Fields:    Translation:Cells
  83. Alper JS, Beckwith J. Racism: a central problem for the Human Genome Diversity Project. Politics Life Sci. 1999 Sep; 18(2):285-8. PMID: 12542056.
    Citations: 1     Fields:    Translation:Humans
  84. Aslund F, Zheng M, Beckwith J, Storz G. Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6161-5. PMID: 10339558.
    Citations: 136     Fields:    Translation:Cells
  85. Aslund F, Beckwith J. Bridge over troubled waters: sensing stress by disulfide bond formation. Cell. 1999 Mar 19; 96(6):751-3. PMID: 10102262.
    Citations: 44     Fields:    
  86. Aslund F, Beckwith J. The thioredoxin superfamily: redundancy, specificity, and gray-area genomics. J Bacteriol. 1999 Mar; 181(5):1375-9. PMID: 10049365.
    Citations: 38     Fields:    Translation:Cells
  87. Chen JC, Weiss DS, Ghigo JM, Beckwith J. Septal localization of FtsQ, an essential cell division protein in Escherichia coli. J Bacteriol. 1999 Jan; 181(2):521-30. PMID: 9882666.
    Citations: 54     Fields:    Translation:Cells
  88. Ghigo JM, Weiss DS, Chen JC, Yarrow JC, Beckwith J. Localization of FtsL to the Escherichia coli septal ring. Mol Microbiol. 1999 Jan; 31(2):725-37. PMID: 10027987.
    Citations: 31     Fields:    Translation:Cells
  89. Weiss DS, Chen JC, Ghigo JM, Boyd D, Beckwith J. Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL. J Bacteriol. 1999 Jan; 181(2):508-20. PMID: 9882665.
    Citations: 184     Fields:    Translation:Cells
  90. Stewart EJ, Aslund F, Beckwith J. Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins. EMBO J. 1998 Oct 01; 17(19):5543-50. PMID: 9755155.
    Citations: 99     Fields:    Translation:Cells
  91. Debarbieux L, Beckwith J. The reductive enzyme thioredoxin 1 acts as an oxidant when it is exported to the Escherichia coli periplasm. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10751-6. PMID: 9724776.
    Citations: 36     Fields:    Translation:Cells
  92. Leeds JA, Beckwith J. Lambda repressor N-terminal DNA-binding domain as an assay for protein transmembrane segment interactions in vivo. J Mol Biol. 1998 Jul 31; 280(5):799-810. PMID: 9671551.
    Citations: 9     Fields:    Translation:Cells
  93. Prinz WA, Boyd DH, Ehrmann M, Beckwith J. The protein translocation apparatus contributes to determining the topology of an integral membrane protein in Escherichia coli. J Biol Chem. 1998 Apr 03; 273(14):8419-24. PMID: 9525953.
    Citations: 8     Fields:    Translation:Cells
  94. Alper JS, Beckwith J. Distinguishing genetic from nongenetic medical tests: some implications for antidiscrimination legislation. Sci Eng Ethics. 1998 Apr; 4(2):141-50. PMID: 11657770.
    Citations: 6     Fields:    Translation:Humans
  95. Boyd D, Schierle C, Beckwith J. How many membrane proteins are there? Protein Sci. 1998 Jan; 7(1):201-5. PMID: 9514275.
    Citations: 37     Fields:    Translation:Cells
  96. Beckwith J, Alper JS. Reconsidering genetic antidiscrimination legislation. J Law Med Ethics. 1998; 26(3):205-10, 178. PMID: 11066878.
    Citations: 4     Fields:    Translation:Humans
  97. Rietsch A, Beckwith J. The genetics of disulfide bond metabolism. Annu Rev Genet. 1998; 32:163-84. PMID: 9928478.
    Citations: 64     Fields:    Translation:Cells
  98. Pohlschröder M, Prinz WA, Hartmann E, Beckwith J. Protein translocation in the three domains of life: variations on a theme. Cell. 1997 Nov 28; 91(5):563-6. PMID: 9393849.
    Citations: 42     Fields:    
  99. Rietsch A, Bessette P, Georgiou G, Beckwith J. Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin. J Bacteriol. 1997 Nov; 179(21):6602-8. PMID: 9352906.
    Citations: 67     Fields:    Translation:Cells
  100. Guzman LM, Weiss DS, Beckwith J. Domain-swapping analysis of FtsI, FtsL, and FtsQ, bitopic membrane proteins essential for cell division in Escherichia coli. J Bacteriol. 1997 Aug; 179(16):5094-103. PMID: 9260951.
    Citations: 40     Fields:    Translation:Cells
  101. Weiss DS, Pogliano K, Carson M, Guzman LM, Fraipont C, Nguyen-Distèche M, Losick R, Beckwith J. Localization of the Escherichia coli cell division protein Ftsl (PBP3) to the division site and cell pole. Mol Microbiol. 1997 Aug; 25(4):671-81. PMID: 9379897.
    Citations: 52     Fields:    Translation:Cells
  102. Prinz WA, Aslund F, Holmgren A, Beckwith J. The role of the thioredoxin and glutaredoxin pathways in reducing protein disulfide bonds in the Escherichia coli cytoplasm. J Biol Chem. 1997 Jun 20; 272(25):15661-7. PMID: 9188456.
    Citations: 124     Fields:    Translation:Cells
  103. Pogliano J, Lynch AS, Belin D, Lin EC, Beckwith J. Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system. Genes Dev. 1997 May 01; 11(9):1169-82. PMID: 9159398.
    Citations: 112     Fields:    Translation:Cells
  104. Beckwith J, Geller LN. Commentary on "The social responsibilities of biological scientists" (S.J. Reiser and R.E. Bulger) Sci Eng Ethics. 1997 Apr; 3(2):145-8. PMID: 11657885.
    Citations:    Fields:    Translation:Humans
  105. Pogliano J, Pogliano K, Weiss DS, Losick R, Beckwith J. Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):559-64. PMID: 9012823.
    Citations: 78     Fields:    Translation:Cells
  106. Rietsch A, Belin D, Martin N, Beckwith J. An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13048-53. PMID: 8917542.
    Citations: 97     Fields:    Translation:Cells
  107. Prinz WA, Spiess C, Ehrmann M, Schierle C, Beckwith J. Targeting of signal sequenceless proteins for export in Escherichia coli with altered protein translocase. EMBO J. 1996 Oct 01; 15(19):5209-17. PMID: 8895566.
    Citations: 18     Fields:    Translation:Cells
  108. Pohlschröder M, Murphy C, Beckwith J. In vivo analyses of interactions between SecE and SecY, core components of the Escherichia coli protein translocation machinery. J Biol Chem. 1996 Aug 16; 271(33):19908-14. PMID: 8702704.
    Citations: 13     Fields:    Translation:Cells
  109. Allen A, Anderson B, Andrews L, Beckwith J, Bowman J, Cook-Deegan R, Cox D, Duster T, Eisenberg R, Fine B, Holtzman N, King P, Kitcher P, McInerney J, McKusick V, Mulvihill J, Murray J, Murray R, Murray T, Nelkin D, Rapp R, Saxton M, Wexler N. The Bell Curve: statement by the NIH-DOE Joint Working Group on the Ethical, Legal, and Social Implications of Human Genome Research. Am J Hum Genet. 1996 Aug; 59(2):487-8. PMID: 8755944.
    Citations: 1     Fields:    Translation:Humans
  110. Jander G, Cronan JE, Beckwith J. Biotinylation in vivo as a sensitive indicator of protein secretion and membrane protein insertion. J Bacteriol. 1996 Jun; 178(11):3049-58. PMID: 8655479.
    Citations: 18     Fields:    
  111. Geller LN, Alper JS, Billings PR, Barash CI, Beckwith J, Natowicz MR. Individual, family, and societal dimensions of genetic discrimination: a case study analysis. Sci Eng Ethics. 1996 Jan; 2(1):71-88. PMID: 11657787.
    Citations: 20     Fields:    Translation:Humans
  112. Economou A, Pogliano JA, Beckwith J, Oliver DB, Wickner W. SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF. Cell. 1995 Dec 29; 83(7):1171-81. PMID: 8548804.
    Citations: 95     Fields:    Translation:Cells
  113. Guilhot C, Jander G, Martin NL, Beckwith J. Evidence that the pathway of disulfide bond formation in Escherichia coli involves interactions between the cysteines of DsbB and DsbA. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9895-9. PMID: 7568240.
    Citations: 45     Fields:    Translation:Cells
  114. Guzman LM, Belin D, Carson MJ, Beckwith J. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol. 1995 Jul; 177(14):4121-30. PMID: 7608087.
    Citations: 1829     Fields:    Translation:Cells
  115. Derman AI, Beckwith J. Escherichia coli alkaline phosphatase localized to the cytoplasm slowly acquires enzymatic activity in cells whose growth has been suspended: a caution for gene fusion studies. J Bacteriol. 1995 Jul; 177(13):3764-70. PMID: 7601842.
    Citations: 22     Fields:    Translation:Cells
  116. Murphy CK, Stewart EJ, Beckwith J. A double counter-selection system for the study of null alleles of essential genes in Escherichia coli. Gene. 1995 Mar 21; 155(1):1-7. PMID: 7698651.
    Citations: 8     Fields:    Translation:Cells
  117. Barondess JJ, Beckwith J. bor gene of phage lambda, involved in serum resistance, encodes a widely conserved outer membrane lipoprotein. J Bacteriol. 1995 Mar; 177(5):1247-53. PMID: 7868598.
    Citations: 28     Fields:    Translation:Cells
  118. Murphy C, Prinz W, Pohlschröder M, Derman A, Beckwith J. Essential features of the pathway for protein translocation across the Escherichia coli cytoplasmic membrane. Cold Spring Harb Symp Quant Biol. 1995; 60:277-83. PMID: 8824401.
    Citations: 1     Fields:    Translation:Cells
  119. Jander G, Martin NL, Beckwith J. Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation. EMBO J. 1994 Nov 01; 13(21):5121-7. PMID: 7957076.
    Citations: 34