Harvard Catalyst Profiles

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Benjamin D. Medoff, M.D.

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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL133153 (MEDOFF, BENJAMIN D) Jul 1, 2016 - Oct 31, 2020
    NIH
    Targeting Cell-specific Functions of the Rho Kinase Pathway in Pulmonary Fibrosis
    Role: Co-Principal Investigator
  2. U01HL121827 (MEDOFF, BENJAMIN D) Sep 26, 2013 - Aug 31, 2019
    NIH
    HIV and COPD:Immune mediated mechanisms
    Role: Co-Principal Investigator
  3. R01HL088297 (XAVIER, RAMNIK J) Apr 1, 2008 - Feb 28, 2013
    NIH
    Role of Carma1 in Inflammatory Lung Disease
    Role: Principal Investigator
  4. K08HL072775 (MEDOFF, BENJAMIN D) Aug 4, 2003 - Jul 31, 2008
    NIH
    Chemokines in lung transplantation
    Role: Principal Investigator
  5. F32AI050399 (MEDOFF, BENJAMIN D) Jul 1, 2002 - Aug 1, 2003
    NIH
    Role of the Leukotriene B4 Receptors in Asthma
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Knipe RS, Nurunnabi M, Probst CK, Spinney JJ, Abe E, Bose RJC, Ha K, Logue A, Nguyen T, Servis R, Drummond M, Haring A, Brazee PL, Medoff BD, McCarthy JR. Myofibroblast-specific inhibition of the Rho kinase-MRTF-SRF pathway using nanotechnology for the prevention of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2023 02 01; 324(2):L190-L198. PMID: 36625494; PMCID: PMC9925159.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Villalba JA, Hilburn CF, Garlin MA, Elliott GA, Li Y, Kunitoki K, Poli S, Alba GA, Madrigal E, Taso M, Price MC, Aviles AJ, Araujo-Medina M, Bonanno L, Boyraz B, Champion SN, Harris CK, Helland TL, Hutchison B, Jobbagy S, Marshall MS, Shepherd DJ, Barth JL, Hung YP, Ly A, Hariri LP, Turbett SE, Pierce VM, Branda JA, Rosenberg ES, Mendez-Pena J, Chebib I, Rosales IA, Smith RN, Miller MA, Rosas IO, Hardin CC, Baden LR, Medoff BD, Colvin RB, Little BP, Stone JR, Mino-Kenudson M, Shih AR. Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2022 10 01; 206(7):857-873. PMID: 35671465; PMCID: PMC9799276.
    Citations: 8     Fields:    Translation:Humans
  3. Nandy S, Berigei SR, Keyes CM, Muniappan A, Auchincloss HG, Lanuti M, Roop BW, Shih AR, Colby TV, Medoff BD, Suter MJ, Villiger M, Hariri LP. Polarization-Sensitive Endobronchial Optical Coherence Tomography for Microscopic Imaging of Fibrosis in Interstitial Lung Disease. Am J Respir Crit Care Med. 2022 10 01; 206(7):905-910. PMID: 35675552.
    Citations:    Fields:    Translation:Humans
  4. Yang Y, Santos DM, Pantano L, Knipe R, Abe E, Logue A, Pronzati G, Black KE, Spinney JJ, Giacona F, Bieler M, Godbout C, Nicklin P, Wyatt D, Tager AM, Seither P, Herrmann FE, Medoff BD. Screening for Inhibitors of YAP Nuclear Localization Identifies Aurora Kinase A as a Modulator of Lung Fibrosis. Am J Respir Cell Mol Biol. 2022 07; 67(1):36-49. PMID: 35377835; PMCID: PMC9798384.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Nandy S, Raphaely RA, Muniappan A, Shih A, Roop BW, Sharma A, Keyes CM, Colby TV, Auchincloss HG, Gaissert HA, Lanuti M, Morse CR, Ott HC, Wain JC, Wright CD, Garcia-Moliner ML, Smith ML, VanderLaan PA, Berigei SR, Mino-Kenudson M, Horick NK, Liang LL, Davies DL, Szabari MV, Caravan P, Medoff BD, Tager AM, Suter MJ, Hariri LP. Reply to Kalverda et al.: Endobronchial Optical Coherence Tomography: Shining New Light on Diagnosing Usual Interstitial Pneumonitis? Am J Respir Crit Care Med. 2022 04 15; 205(8):968-971. PMID: 35148493; PMCID: PMC9838623.
    Citations:    Fields:    Translation:Humans
  6. Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD. Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 01; 66(1):38-52. PMID: 34343038; PMCID: PMC8803357.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Nandy S, Raphaely RA, Muniappan A, Shih A, Roop BW, Sharma A, Keyes CM, Colby TV, Auchincloss HG, Gaissert HA, Lanuti M, Morse CR, Ott HC, Wain JC, Wright CD, Garcia-Moliner ML, Smith ML, VanderLaan PA, Berigei SR, Mino-Kenudson M, Horick NK, Liang LL, Davies DL, Szabari MV, Caravan P, Medoff BD, Tager AM, Suter MJ, Hariri LP. Diagnostic Accuracy of Endobronchial Optical Coherence Tomography for the Microscopic Diagnosis of Usual Interstitial Pneumonia. Am J Respir Crit Care Med. 2021 11 15; 204(10):1164-1179. PMID: 34375171; PMCID: PMC8759308.
    Citations: 8     Fields:    Translation:Humans
  8. Corleis B, Cho JL, Gates SJ, Linder AH, Dickey A, Lisanti-Park AC, Schiff AE, Ghebremichael M, Kohli P, Winkler T, Harris RS, Medoff BD, Kwon DS. Smoking and Human Immunodeficiency Virus 1 Infection Promote Retention of CD8+ T Cells in the Airway Mucosa. Am J Respir Cell Mol Biol. 2021 11; 65(5):513-520. PMID: 34166603; PMCID: PMC8641855.
    Citations: 4     Fields:    Translation:HumansCells
  9. Zubiri L, Molina GE, Mooradian MJ, Cohen J, Durbin SM, Petrillo L, Boland GM, Juric D, Dougan M, Thomas MF, Faje AT, Rengarajan M, Guidon AC, Chen ST, Okin D, Medoff BD, Nasrallah M, Kohler MJ, Schoenfeld SR, Karp-Leaf RS, Sise ME, Neilan TG, Zlotoff DA, Farmer JR, Bardia A, Sullivan RJ, Blum SM, Semenov YR, Villani AC, Reynolds KL. Effect of a multidisciplinary Severe Immunotherapy Complications Service on outcomes for patients receiving immune checkpoint inhibitor therapy for cancer. J Immunother Cancer. 2021 09; 9(9). PMID: 34544895; PMCID: PMC8454442.
    Citations: 3     Fields:    Translation:Humans
  10. Alba GA, Ziehr DR, Rouvina JN, Hariri LP, Knipe RS, Medoff BD, Hibbert KA, Kowal A, Hoenstine C, Ginns LC, Lewis GD, Hardin CC. Exercise performance in patients with post-acute sequelae of SARS-CoV-2 infection compared to patients with unexplained dyspnea. EClinicalMedicine. 2021 Sep; 39:101066. PMID: 34476393; PMCID: PMC8401400.
    Citations: 16     
  11. Gard AL, Luu RJ, Miller CR, Maloney R, Cain BP, Marr EE, Burns DM, Gaibler R, Mulhern TJ, Wong CA, Alladina J, Coppeta JR, Liu P, Wang JP, Azizgolshani H, Fezzie RF, Balestrini JL, Isenberg BC, Medoff BD, Finberg RW, Borenstein JT. High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro. Sci Rep. 2021 07 22; 11(1):14961. PMID: 34294757.
    Citations: 8     Fields:    Translation:HumansCells
  12. Alladina JW, Giacona FL, White EB, Brait KL, Abe EA, Michelhaugh SA, Hibbert KA, Januzzi JL, Thompson BT, Cho JL, Medoff BD. Soluble Suppression of Tumorigenicity-2 Associates With Ventilator Dependence in Coronavirus Disease 2019 Respiratory Failure. Crit Care Explor. 2021 Jul; 3(7):e0480. PMID: 34235459.
    Citations: 2     
  13. Alladina J, Levy SD, Cho JL, Brait KL, Rao SR, Camacho A, Hibbert KA, Harris RS, Medoff BD, Januzzi JL, Thompson BT, Bajwa EK. Plasma Soluble Suppression of Tumorigenicity-2 Associates with Ventilator Liberation in Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2021 05 15; 203(10):1257-1265. PMID: 33400890.
    Citations: 5     Fields:    Translation:Humans
  14. McNeill JN, Lau ES, Zern EK, Nayor M, Malhotra R, Liu EE, Bhat RR, Brooks LC, Farrell R, Sbarbaro JA, Schoenike MW, Medoff BD, Lewis GD, Ho JE. Association of obesity-related inflammatory pathways with lung function and exercise capacity. Respir Med. 2021 07; 183:106434. PMID: 33964816; PMCID: PMC8144063.
    Citations: 2     Fields:    Translation:HumansCells
  15. Molina GE, Zubiri L, Cohen JV, Durbin SM, Petrillo L, Allen IM, Murciano-Goroff YR, Dougan M, Thomas MF, Faje AT, Rengarajan M, Guidon AC, Chen ST, Okin D, Medoff BD, Nasrallah M, Kohler MJ, Schoenfeld SR, Karp Leaf RS, Sise ME, Neilan TG, Zlotoff DA, Farmer JR, Mooradian MJ, Bardia A, Mai M, Sullivan RJ, Semenov YR, Villani AC, Reynolds KL. Temporal Trends and Outcomes Among Patients Admitted for Immune-Related Adverse Events: A Single-Center Retrospective Cohort Study from 2011 to 2018. Oncologist. 2021 06; 26(6):514-522. PMID: 33655682; PMCID: PMC8176966.
    Citations: 9     Fields:    Translation:Humans
  16. Schiff AE, Linder AH, Luhembo SN, Banning S, Deymier MJ, Diefenbach TJ, Dickey AK, Tsibris AM, Balazs AB, Cho JL, Medoff BD, Walzl G, Wilkinson RJ, Burgers WA, Corleis B, Kwon DS. T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+?T cells. Sci Rep. 2021 02 16; 11(1):3890. PMID: 33594125; PMCID: PMC7886866.
    Citations: 7     Fields:    Translation:HumansCells
  17. Schwartzstein RM, Medoff BD, Sharma A, Sharma A, Colson YL, Gainor J, Hariri LP. Case 4-2021: A 70-Year-Old Woman with Dyspnea on Exertion and Abnormal Findings on Chest Imaging. N Engl J Med. 2021 Feb 11; 384(6):563-574. PMID: 33567196.
    Citations:    Fields:    Translation:HumansCells
  18. Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Reply to Yaroshetskiy et al.: Acute Respiratory Distress Syndrome in COVID-19: Do All These Patients Definitely Require Intubation and Mechanical Ventilation? Am J Respir Crit Care Med. 2020 11 15; 202(10):1481-1482. PMID: 32809839; PMCID: PMC7667895.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  19. Hariri LP, North CM, Shih AR, Israel RA, Maley JH, Villalba JA, Vinarsky V, Rubin J, Okin DA, Sclafani A, Alladina JW, Griffith JW, Gillette MA, Raz Y, Richards CJ, Wong AK, Ly A, Hung YP, Chivukula RR, Petri CR, Calhoun TF, Brenner LN, Hibbert KA, Medoff BD, Hardin CC, Stone JR, Mino-Kenudson M. Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review. Chest. 2021 01; 159(1):73-84. PMID: 33038391; PMCID: PMC7538870.
    Citations: 74     Fields:    Translation:HumansCells
  20. Faustino LD, Griffith JW, Rahimi RA, Nepal K, Hamilos DL, Cho JL, Medoff BD, Moon JJ, Vignali DAA, Luster AD. Interleukin-33 activates regulatory T cells to suppress innate ?d T cell responses in the lung. Nat Immunol. 2020 11; 21(11):1371-1383. PMID: 32989331; PMCID: PMC7578082.
    Citations: 20     Fields:    Translation:AnimalsCells
  21. Kohli P, Kelly VJ, Hibbert KA, Corleis B, Kone M, Cho JL, DeFaria-Yeh D, Kwon DS, Medoff BD, Harris RS, Winkler T. PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking. J Nucl Med. 2021 03; 62(3):405-411. PMID: 32764123.
    Citations: 1     Fields:    Translation:Humans
  22. Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Reply to Epelbaum: Standards and Stereotypes in COVID-19. Am J Respir Crit Care Med. 2020 08 01; 202(3):470-471. PMID: 32510977; PMCID: PMC7397799.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  23. Probst CK, Montesi SB, Medoff BD, Shea BS, Knipe RS. Vascular permeability in the fibrotic lung. Eur Respir J. 2020 07; 56(1). PMID: 32265308; PMCID: PMC9977144.
    Citations: 26     Fields:    Translation:Humans
  24. Mendoza DP, Kohli P, Nance JW, Singh R, Cho J, Griffith J, Harris RS, Kelly VJ, Luster AD, Medoff B, Digumarthy SR. Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects. Ann Transl Med. 2020 Jul; 8(14):862. PMID: 32793706; PMCID: PMC7396741.
    Citations: 1     
  25. Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study. Am J Respir Crit Care Med. 2020 06 15; 201(12):1560-1564. PMID: 32348678; PMCID: PMC7301734.
    Citations: 225     Fields:    Translation:HumansCellsPHPublic Health
  26. Santos DM, Pantano L, Pronzati G, Grasberger P, Probst CK, Black KE, Spinney JJ, Hariri LP, Nichols R, Lin Y, Bieler M, Seither P, Nicklin P, Wyatt D, Tager AM, Medoff BD. Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis. Am J Respir Cell Mol Biol. 2020 04; 62(4):479-492. PMID: 31944822; PMCID: PMC7110981.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Di Pilato M, Kim EY, Cadilha BL, Prüßmann JN, Nasrallah MN, Seruggia D, Usmani SM, Misale S, Zappulli V, Carrizosa E, Mani V, Ligorio M, Warner RD, Medoff BD, Marangoni F, Villani AC, Mempel TR. Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. Nature. 2019 06; 570(7759):112-116. PMID: 31092922; PMCID: PMC6656391.
    Citations: 77     Fields:    Translation:AnimalsCells
  28. Adams DC, Miller AJ, Applegate MB, Cho JL, Hamilos DL, Chee A, Holz JA, Szabari MV, Hariri LP, Harris RS, Griffith JW, Luster AD, Medoff BD, Suter MJ. Quantitative assessment of airway remodelling and response to allergen in asthma. Respirology. 2019 11; 24(11):1073-1080. PMID: 30845351.
    Citations: 10     Fields:    Translation:Humans
  29. Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis. Cell Rep. 2019 02 05; 26(6):1409-1418.e5. PMID: 30726727; PMCID: PMC6417097.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  30. Causton B, Pardo-Saganta A, Gillis J, Discipio K, Kooistra T, Rajagopal J, Xavier RJ, Cho JL, Medoff BD. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol. 2018 12; 59(6):684-694. PMID: 29958012; PMCID: PMC6293075.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  31. Cho JL, Medoff BD. Chronic Obstructive Pulmonary Disease: Back to the Basics. Am J Respir Crit Care Med. 2018 11 15; 198(10):1241-1242. PMID: 30011221.
    Citations: 2     Fields:    Translation:Humans
  32. Knipe RS, Probst CK, Lagares D, Franklin A, Spinney JJ, Brazee PL, Grasberger P, Zhang L, Black KE, Sakai N, Shea BS, Liao JK, Medoff BD, Tager AM. The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 04; 58(4):471-481. PMID: 29211497; PMCID: PMC5894496.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  33. Adams DC, Pahlevaninezhad H, Szabari MV, Cho JL, Hamilos DL, Kesimer M, Boucher RC, Luster AD, Medoff BD, Suter MJ. Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography. Biomed Opt Express. 2017 Oct 01; 8(10):4729-4741. PMID: 29082098; PMCID: PMC5654813.
    Citations: 9     
  34. Adams DC, Hariri LP, Miller AJ, Wang Y, Cho JL, Villiger M, Holz JA, Szabari MV, Hamilos DL, Scott Harris R, Griffith JW, Bouma BE, Luster AD, Medoff BD, Suter MJ. Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo. Sci Transl Med. 2016 10 05; 8(359):359ra131. PMID: 27708064.
    Citations: 42     Fields:    Translation:HumansAnimals
  35. Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD. Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med. 2016 10 05; 8(359):359ra132. PMID: 27708065; PMCID: PMC5399547.
    Citations: 22     Fields:    Translation:HumansCells
  36. Kleinsteuber K, Corleis B, Rashidi N, Nchinda N, Lisanti A, Cho JL, Medoff BD, Kwon D, Walker BD. Standardization and quality control for high-dimensional mass cytometry studies of human samples. Cytometry A. 2016 10; 89(10):903-913. PMID: 27575385.
    Citations: 28     Fields:    Translation:HumansCells
  37. Kelly VJ, Winkler T, Venegas JG, Kone M, Hamilos DL, Afshar R, Cho JL, Luster AD, Medoff BD, Harris RS. Allergic Non-Asthmatic Adults Have Regional Pulmonary Responses to Segmental Allergen Challenge. PLoS One. 2015; 10(12):e0143976. PMID: 26640951.
    Citations: 1     Fields:    Translation:Humans
  38. Causton B, Ramadas RA, Cho JL, Jones K, Pardo-Saganta A, Rajagopal J, Xavier RJ, Medoff BD. CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. J Immunol. 2015 Jul 15; 195(2):683-94. PMID: 26041536; PMCID: PMC4489191.
    Citations: 10     Fields:    Translation:AnimalsCells
  39. Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, Sharpe AH, Shaw SY, Xavier RJ. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells. Elife. 2015 May 22; 4. PMID: 25998054; PMCID: PMC4441007.
    Citations: 19     Fields:    Translation:AnimalsCells
  40. Cho JL, Medoff BD. Lung T cells in HIV infection. Driven to exhaustion? Am J Respir Crit Care Med. 2015 Feb 15; 191(4):370-1. PMID: 25679103.
    Citations:    Fields:    Translation:HumansCells
  41. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013 Nov 14; 503(7475):218-23. PMID: 24196716.
    Citations: 311     Fields:    Translation:AnimalsCells
  42. Wu Q, Gardiner GJ, Berry E, Wagner SR, Lu T, Clay BS, Moore TV, Ferreira CM, Williams JW, Luster AD, Medoff BD, Cannon JL, Sperling AI, Shilling RA. ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection. PLoS One. 2013; 8(8):e72955. PMID: 23967339.
    Citations: 5     Fields:    Translation:AnimalsCells
  43. Afshar R, Strassner JP, Seung E, Causton B, Cho JL, Harris RS, Hamilos DL, Medoff BD, Luster AD. Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation. J Allergy Clin Immunol. 2013 Jun; 131(6):1644-52. PMID: 23632297; PMCID: PMC3703653.
    Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  44. Roche MI, Ramadas RA, Medoff BD. The role of CARMA1 in T cells. Crit Rev Immunol. 2013; 33(3):219-43. PMID: 23756245.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  45. Hariri LP, Applegate MB, Mino-Kenudson M, Mark EJ, Medoff BD, Luster AD, Bouma BE, Tearney GJ, Suter MJ. Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology. Chest. 2013 Jan; 143(1):64-74. PMID: 22459781; PMCID: PMC3537541.
    Citations: 28     Fields:    Translation:Humans
  46. Ramadas RA, Ewart SL, Iwakura Y, Medoff BD, LeVine AM. IL-36a exerts pro-inflammatory effects in the lungs of mice. PLoS One. 2012; 7(9):e45784. PMID: 23029241.
    Citations: 42     Fields:    Translation:AnimalsCells
  47. Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD. Enhanced Tim3 activity improves survival after influenza infection. J Immunol. 2012 Sep 15; 189(6):2879-89. PMID: 22875804; PMCID: PMC3436990.
    Citations: 15     Fields:    Translation:AnimalsCells
  48. Medoff BD. Fat, fire and muscle--the role of adiponectin in pulmonary vascular inflammation and remodeling. Pulm Pharmacol Ther. 2013 Aug; 26(4):420-6. PMID: 22750271.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  49. Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD. CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma. J Immunol. 2011 Dec 15; 187(12):6197-207. PMID: 22075698; PMCID: PMC3237896.
    Citations: 10     Fields:    Translation:AnimalsCells
  50. Harris RS, Venegas JG, Wongviriyawong C, Winkler T, Kone M, Musch G, Vidal Melo MF, de Prost N, Hamilos DL, Afshar R, Cho J, Luster AD, Medoff BD. 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med. 2011 Nov; 52(11):1713-20. PMID: 21990575.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  51. Summer R, Walsh K, Medoff BD. Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions? Pulm Circ. 2011 Oct-Dec; 1(4):440-7. PMID: 22530098.
    Citations: 26     
  52. Weng M, Baron DM, Bloch KD, Luster AD, Lee JJ, Medoff BD. Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L927-36. PMID: 21908591.
    Citations: 20     Fields:    Translation:AnimalsCells
  53. Nishino M, Medoff BD, Mark EJ, Matsubara O, O'Donnell WJ, Currier PF, Kradin RL. Variant alveolar lipoproteinosis: a syndrome with distinct clinical and pathological features. Pathol Int. 2011 Sep; 61(9):509-17. PMID: 21884300.
    Citations: 1     Fields:    Translation:HumansCells
  54. Seung E, Cho JL, Sparwasser T, Medoff BD, Luster AD. Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol. 2011 Jun 15; 186(12):6830-8. PMID: 21555535; PMCID: PMC3859457.
    Citations: 14     Fields:    Translation:AnimalsCells
  55. Weng M, Raher MJ, Leyton P, Combs TP, Scherer PE, Bloch KD, Medoff BD. Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):340-7. PMID: 21075862.
    Citations: 27     Fields:    Translation:AnimalsCells
  56. Cowherd RB, Cowerd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH, Bodnar WM, Rusyn I, Medoff BD, Tisch R, Mayer-Davis E, Swenberg JA, Zeisel SH, Combs TP. Adiponectin lowers glucose production by increasing SOGA. Am J Pathol. 2010 Oct; 177(4):1936-45. PMID: 20813965; PMCID: PMC2947288.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  57. Medoff BD, Abbott GF, Louissaint A. Case records of the Massachusetts General Hospital. Case 16-2010. A 48-year-old man with a cough and pain in the left shoulder. N Engl J Med. 2010 May 27; 362(21):2013-22. PMID: 20505181.
    Citations: 3     Fields:    Translation:Humans
  58. Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R. Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography. Opt Lett. 2010 Apr 01; 35(7):1088-90. PMID: 20364226.
    Citations: 3     Fields:    
  59. Ramadas RA, Ewart SL, Medoff BD, LeVine AM. Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs. Am J Respir Cell Mol Biol. 2011 Feb; 44(2):134-45. PMID: 20299540; PMCID: PMC3049228.
    Citations: 58     Fields:    Translation:AnimalsCells
  60. Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P, Luster AD. Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol. 2009 Oct; 41(4):397-406. PMID: 19168697.
    Citations: 87     Fields:    Translation:AnimalsCells
  61. Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD. CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol. 2009 Jan 01; 182(1):623-35. PMID: 19109196; PMCID: PMC2718444.
    Citations: 55     Fields:    Translation:AnimalsCells
  62. Medoff BD, Sandall BP, Landry A, Nagahama K, Mizoguchi A, Luster AD, Xavier RJ. Differential requirement for CARMA1 in agonist-selected T-cell development. Eur J Immunol. 2009 Jan; 39(1):78-84. PMID: 19130560.
    Citations: 43     Fields:    Translation:AnimalsCells
  63. Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20321-6. PMID: 19073936; PMCID: PMC2600581.
    Citations: 79     Fields:    Translation:AnimalsCells
  64. Mikhak Z, Fukui M, Farsidjani A, Medoff BD, Tager AM, Luster AD. Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation. J Allergy Clin Immunol. 2009 Jan; 123(1):67-73.e3. PMID: 19062085; PMCID: PMC2782398.
    Citations: 51     Fields:    Translation:AnimalsCells
  65. Afshar R, Medoff BD, Luster AD. Allergic asthma: a tale of many T cells. Clin Exp Allergy. 2008 Dec; 38(12):1847-57. PMID: 19037961.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  66. Fadel SA, Bromley SK, Medoff BD, Luster AD. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Eur J Immunol. 2008 Dec; 38(12):3376-87. PMID: 19039768.
    Citations: 34     Fields:    Translation:AnimalsCells
  67. Medoff BD, Landry AL, Wittbold KA, Sandall BP, Derby MC, Cao Z, Adams JC, Xavier RJ. CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):286-94. PMID: 18757306.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  68. Medoff BD. Invasive and noninvasive ventilation in patients with asthma. Respir Care. 2008 Jun; 53(6):740-48; discussion 749-50. PMID: 18501028.
    Citations: 6     Fields:    Translation:Humans
  69. Campanella GS, Medoff BD, Manice LA, Colvin RA, Luster AD. Development of a novel chemokine-mediated in vivo T cell recruitment assay. J Immunol Methods. 2008 Feb 29; 331(1-2):127-39. PMID: 18206159.
    Citations: 25     Fields:    Translation:AnimalsCells
  70. Medoff BD, Thomas SY, Luster AD. T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol. 2008; 26:205-32. PMID: 18304002.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  71. Thomas SY, Banerji A, Medoff BD, Lilly CM, Luster AD. Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway. J Immunol. 2007 Aug 01; 179(3):1901-12. PMID: 17641057.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  72. Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD. Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity. J Immunol. 2006 Nov 15; 177(10):6991-8. PMID: 17082614.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  73. Medoff BD, Seed B, Jackobek R, Zora J, Yang Y, Luster AD, Xavier R. CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. J Immunol. 2006 Jun 15; 176(12):7272-7. PMID: 16751370.
    Citations: 22     Fields:    Translation:AnimalsCells
  74. Medoff BD, Wain JC, Seung E, Jackobek R, Means TK, Ginns LC, Farber JM, Luster AD. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. J Immunol. 2006 Jun 01; 176(11):7087-95. PMID: 16709871.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  75. Mikhak Z, Fleming CM, Medoff BD, Thomas SY, Tager AM, Campanella GS, Luster AD. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol. 2006 Apr 15; 176(8):4959-67. PMID: 16585592.
    Citations: 35     Fields:    Translation:AnimalsCells
  76. Medoff BD, Thomas SY, Banerji A, Wain JC, Zhang H, Lilly CM, Ginns LC, Luster AD. Pathogenic T-cell recruitment into the airway in human disease. Ann N Y Acad Sci. 2005 Dec; 1062:220-41. PMID: 16461804.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  77. Castro O, Gladwin MT, Kopterides P, Fremont R, Medoff BD. Case 17-2005: acute chest syndrome and ARDS. N Engl J Med. 2005 Oct 06; 353(14):1529-30; author reply 1529-30. PMID: 16207862.
    Citations: 1     Fields:    Translation:Humans
  78. Islam SA, Thomas SY, Hess C, Medoff BD, Means TK, Brander C, Lilly CM, Tager AM, Luster AD. The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans. Blood. 2006 Jan 15; 107(2):444-53. PMID: 16179368; PMCID: PMC1490027.
    Citations: 25     Fields:    Translation:HumansCells
  79. Medoff BD, Tager AM, Jackobek R, Means TK, Wang L, Luster AD. Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1. Am J Physiol Lung Cell Mol Physiol. 2006 Jan; 290(1):L170-8. PMID: 16126787.
    Citations: 18     Fields:    Translation:AnimalsCells
  80. Medoff BD, Seung E, Wain JC, Means TK, Campanella GS, Islam SA, Thomas SY, Ginns LC, Grabie N, Lichtman AH, Tager AM, Luster AD. BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med. 2005 Jul 04; 202(1):97-110. PMID: 15998790; PMCID: PMC2212891.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  81. Medoff BD, Shepard JA, Smith RN, Kratz A. Case records of the Massachusetts General Hospital. Case 17-2005. A 22-year-old woman with back and leg pain and respiratory failure. N Engl J Med. 2005 Jun 09; 352(23):2425-34. PMID: 15944428.
    Citations: 1     Fields:    Translation:Humans
  82. Tager AM, Bromley SK, Medoff BD, Islam SA, Bercury SD, Friedrich EB, Carafone AD, Gerszten RE, Luster AD. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol. 2003 Oct; 4(10):982-90. PMID: 12949531.
    Citations: 127     Fields:    Translation:AnimalsCells
  83. Mathew A, Medoff BD, Carafone AD, Luster AD. Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling. J Immunol. 2002 Jul 15; 169(2):651-5. PMID: 12097366.
    Citations: 12     Fields:    Translation:AnimalsCells
  84. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol. 2002 May 15; 168(10):5278-86. PMID: 11994485.
    Citations: 59     Fields:    Translation:AnimalsCells
  85. Medoff BD, Disalvo TD. Cardiac Failure. Fundamentals of Respiratory Care. 2002.
  86. Bigatello LM, Hess D, Dennehy KC, Medoff BD, Hurford WE. Sildenafil can increase the response to inhaled nitric oxide. Anesthesiology. 2000 Jun; 92(6):1827-9. PMID: 10839936.
    Citations: 6     Fields:    Translation:Humans
  87. Medoff BD, Harris RS, Kesselman H, Venegas J, Amato MB, Hess D. Use of recruitment maneuvers and high-positive end-expiratory pressure in a patient with acute respiratory distress syndrome. Crit Care Med. 2000 Apr; 28(4):1210-6. PMID: 10809308.
    Citations: 18     Fields:    Translation:HumansCells
  88. Iiyama K, Hajra L, Iiyama M, Li H, DiChiara M, Medoff BD, Cybulsky MI. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res. 1999 Jul 23; 85(2):199-207. PMID: 10417402.
    Citations: 211     Fields:    Translation:AnimalsCells
  89. Hess D, Medoff BD. . Current Opinion in Critical Care. Respiratory Monitoring. 1999; 5:52-60.
  90. Hess D, Medoff BD, Fessler M. Respiratory Monitoring. International Anesthesiology Clinics. 1999; 37(3):15-34.
  91. Hess DR, Medoff BD, Fessler MB. Pulmonary mechanics and graphics during positive pressure ventilation. Int Anesthesiol Clin. 1999; 37(3):15-34. PMID: 10445171.
    Citations: 1     Fields:    Translation:Humans
  92. Hess DR, Medoff BD. Mechanical ventilation of the patient with chronic obstructive pulmonary disease. Respir Care Clin N Am. 1998 Sep; 4(3):439-73. PMID: 9770261.
    Citations:    Fields:    Translation:Humans
  93. Oelberg DA, Medoff BD, Markowitz DH, Pappagianopoulos PP, Ginns LC, Systrom DM. Systemic oxygen extraction during incremental exercise in patients with severe chronic obstructive pulmonary disease. Eur J Appl Physiol Occup Physiol. 1998 Aug; 78(3):201-7. PMID: 9720997.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  94. Medoff BD, Oelberg DA, Kanarek DJ, Systrom DM. Breathing reserve at the lactate threshold to differentiate a pulmonary mechanical from cardiovascular limit to exercise. Chest. 1998 Apr; 113(4):913-8. PMID: 9554625.
    Citations: 11     Fields:    Translation:Humans
  95. Hess D, Medoff BD. Mechanical Ventilation in COPD. Respiratory Care Clinics of North America. 1988; 4(3):439-473.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.