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profileGeorge Quentin Daley, M.D., Ph.D.

TitleDean of the Faculty of Medicine
InstitutionHarvard Medical School
DepartmentDean's Office
AddressHarvard Medical School
Gordon Hall, Dean's Office
25 Shattuck St
Boston MA 02115
Phone617/919-2013
Fax617/730-0222
vCardDownload vCard (login for email)
Other Positions
TitleProfessor of Biological Chemistry and Molecular Pharmacology
InstitutionBoston Children's Hospital
DepartmentBiological Chemistry & Molecular Pharmacology

TitleCaroline Shields Walker Professor of Medicine
InstitutionHarvard Medical School
DepartmentBiological Chemistry & Molecular Pharmacology

TitleRobert A. Stranahan Professor of Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
DivisionHematology/Oncology


Collapse Mentoring 
Collapse completed student projects
Investigating Circadian Rhythm in Acute Myeloid Leukemia
Summer, 06/09/14 - 08/15/14
Scl and Notch act downstream of Hedgehog signaling to promote hematopoiesis from endothelial cells
Summer, 06/14/11 - 08/14/11
Embryonic Stem Cell Model of Trisomy 16
Summer, 06/19/06 - 08/26/05
Scl and Notch act downstream of Hedgehog signaling to promote hematopoiesis from endothelial cells
Summer, 09/01/10 - 12/31/10

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01HL134812     (DALEY, GEORGE Q)Sep 23, 2016 - May 31, 2023
NIH/NHLBI
Stem cells for therapeutics discovery in genetic blood disorders
Role: Principal Investigator

R01GM107536     (DALEY, GEORGE Q)Jun 1, 2014 - Mar 31, 2018
NIH/NIGMS
LIN28/let-7 MECHANISMS IN REPROGRAMMING AND METABOLISM
Role: Principal Investigator

R24DK092760     (DALEY, GEORGE Q)Sep 19, 2011 - Jul 31, 2019
NIH/NIDDK
Customized stem cells for clinical application in blood disorders
Role: Co-Principal Investigator

RC4DK090913     (D'ANDREA, ALAN DAVID)Sep 23, 2010 - Aug 31, 2013
NIH/NIDDK
Novel therapies for Fanconi anemia
Role: Co-Principal Investigator

R13HL104873     (DALEY, GEORGE Q)Apr 1, 2010 - Mar 31, 2011
NIH/NHLBI
Second International Conference on Stem Cell Engineering
Role: Principal Investigator
Collapse research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Daley Lab - Embryonic stem cell lines (11) and iPS cells (1)
HSCI iPS Cell Core Facility - Core services (3), Embryonic stem cell lines (28), Primary fibroblast cell lines (1), Protocols (1) and iPS cells (24)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Daley GQ. Polar Extremes in the Clinical Use of Stem Cells. N Engl J Med. 2017 03 16; 376(11):1075-1077. PMID: 28296612.
    View in: PubMed
  2. Tsanov KM, Daley GQ. Signaling through RNA-binding proteins as a cell fate regulatory mechanism. Cell Cycle. 2017 Mar 08; 0. PMID: 28272977.
    View in: PubMed
  3. Doulatov S, Vo LT, Macari ER, Wahlster L, Kinney MA, Taylor AM, Barragan J, Gupta M, McGrath K, Lee HY, Humphries JM, DeVine A, Narla A, Alter BP, Beggs AH, Agarwal S, Ebert BL, Gazda HT, Lodish HF, Sieff CA, Schlaeger TM, Zon LI, Daley GQ. Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Sci Transl Med. 2017 Feb 08; 9(376). PMID: 28179501.
    View in: PubMed
  4. Cohen IG, Daley GQ, Adashi EY. Disruptive reproductive technologies. Sci Transl Med. 2017 Jan 11; 9(372). PMID: 28077678.
    View in: PubMed
  5. Lu YF, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ. Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity. Cell Rep. 2016 Dec 20; 17(12):3178-3192. PMID: 28009288.
    View in: PubMed
  6. Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67. PMID: 27992407.
    View in: PubMed
  7. Rowe RG, Daley GQ. Stem cells: Valine starvation leads to a hungry niche. Nature. 2017 Jan 12; 541(7636):166-167. PMID: 27974805.
    View in: PubMed
  8. Manier S, Powers JT, Sacco A, Glavey SV, Huynh D, Reagan MR, Salem KZ, Moschetta M, Shi J, Mishima Y, Roche-Lestienne C, Leleu X, Roccaro AM, Daley GQ, Ghobrial IM. The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma. Leukemia. 2016 Nov 11. PMID: 27773931.
    View in: PubMed
  9. Gao X, Lee HY, da Rocha EL, Zhang C, Lu YF, Li D, Feng Y, Ezike J, Elmes RR, Barrasa MI, Cahan P, Li H, Daley GQ, Lodish HF. TGF-ß inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors. Blood. 2016 Dec 08; 128(23):2637-2641. PMID: 27777239.
    View in: PubMed
  10. Wahlster L, Daley GQ. Progress towards generation of human haematopoietic stem cells. Nat Cell Biol. 2016 Nov; 18(11):1111-1117. PMID: 27723718.
    View in: PubMed
  11. Cortes M, Chen MJ, Stachura DL, Liu SY, Kwan W, Wright F, Vo LT, Theodore LN, Esain V, Frost IM, Schlaeger TM, Goessling W, Daley GQ, North TE. Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell Rep. 2016 Oct 04; 17(2):458-468. PMID: 27705794.
    View in: PubMed
  12. Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theißen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 2016 07 14; 535(7611):246-51. PMID: 27383785; PMCID: PMC4947006 [Available on 01/06/17].
  13. Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016 Jul 25; 213(8):1497-512. PMID: 27401346; PMCID: PMC4986532 [Available on 01/25/17].
  14. Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016 Jul 07; 19(1):66-80. PMID: 27320042.
    View in: PubMed
  15. Toh CX, Chan JW, Chong ZS, Wang HF, Guo HC, Satapathy S, Ma D, Goh GY, Khattar E, Yang L, Tergaonkar V, Chang YT, Collins JJ, Daley GQ, Wee KB, Farran CA, Li H, Lim YP, Bard FA, Loh YH. RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming. Cell Rep. 2016 Jun 21; 15(12):2597-607. PMID: 27292646.
    View in: PubMed
  16. Rowe RG, Mandelbaum J, Zon LI, Daley GQ. Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell. 2016 Jun 02; 18(6):707-20. PMID: 27257760; PMCID: PMC4911194 [Available on 06/02/17].
  17. Kimmelman J, Hyun I, Benvenisty N, Caulfield T, Heslop HE, Murry CE, Sipp D, Studer L, Sugarman J, Daley GQ. Policy: Global standards for stem-cell research. Nature. 2016 05 19; 533(7603):311-3. PMID: 27193661.
    View in: PubMed
  18. Kimmelman J, Heslop HE, Sugarman J, Studer L, Benvenisty N, Caulfield T, Hyun I, Murry CE, Sipp D, Daley GQ. New ISSCR guidelines: clinical translation of stem cell research. Lancet. 2016 May 14; 387(10032):1979-81. PMID: 27179752.
    View in: PubMed
  19. Caulfield T, Sipp D, Murry CE, Daley GQ, Kimmelman J. SCIENTIFIC COMMUNITY. Confronting stem cell hype. Science. 2016 May 13; 352(6287):776-7. PMID: 27174977.
    View in: PubMed
  20. Daley GQ, Hyun I, Apperley JF, Barker RA, Benvenisty N, Bredenoord AL, Breuer CK, Caulfield T, Cedars MI, Frey-Vasconcells J, Heslop HE, Jin Y, Lee RT, McCabe C, Munsie M, Murry CE, Piantadosi S, Rao M, Rooke HM, Sipp D, Studer L, Sugarman J, Takahashi M, Zimmerman M, Kimmelman J. Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines. Stem Cell Reports. 2016 Jun 14; 6(6):787-97. PMID: 27185282; PMCID: PMC4912385.
  21. Mughal TI, Radich JP, Deininger MW, Apperley JF, Hughes TP, Harrison CJ, Gambacorti-Passerini C, Saglio G, Cortes J, Daley GQ. Chronic myeloid leukemia: reminiscences and dreams. Haematologica. 2016 May; 101(5):541-58. PMID: 27132280; PMCID: PMC5004358.
  22. Kim PG, Canver MC, Rhee C, Ross SJ, Harriss JV, Tu HC, Orkin SH, Tucker HO, Daley GQ. Interferon-a signaling promotes embryonic HSC maturation. Blood. 2016 Jul 14; 128(2):204-16. PMID: 27095787; PMCID: PMC4946201 [Available on 07/14/17].
  23. Corre C, Shinoda G, Zhu H, Cousminer DL, Crossman C, Bellissimo C, Goldenberg A, Daley GQ, Palmert MR. Sex-specific regulation of weight and puberty by the Lin28/let-7 axis. J Endocrinol. 2016 Mar; 228(3):179-91. PMID: 26698568; PMCID: PMC4772724 [Available on 03/01/17].
  24. De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. Corrigendum: Hallmarks of pluripotency. Nature. 2016 Mar 17; 531(7594):400. PMID: 26675727.
    View in: PubMed
  25. De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ. Corrigendum: Failure to replicate the STAP cell phenomenon. Nature. 2016 Mar 17; 531(7594):400. PMID: 26675720.
    View in: PubMed
  26. Daley GQ. Stem cells and the evolving notion of cellular identity. Philos Trans R Soc Lond B Biol Sci. 2015 Oct 19; 370(1680):20140376. PMID: 26416685; PMCID: PMC4634003 [Available on 10/19/16].
  27. Wu L, Nguyen LH, Zhou K, de Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, Zhu H. Precise let-7 expression levels balance organ regeneration against tumor suppression. Elife. 2015 Oct 07; 4:e09431. PMID: 26445246; PMCID: PMC4716837.
  28. De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ. Hallmarks of pluripotency. Nature. 2015 Sep 24; 525(7570):469-78. PMID: 26399828.
    View in: PubMed
  29. De Los Angeles A, Ferrari F, Fujiwara Y, Mathieu R, Lee S, Lee S, Tu HC, Ross S, Chou S, Nguyen M, Wu Z, Theunissen TW, Powell BE, Imsoonthornruksa S, Chen J, Borkent M, Krupalnik V, Lujan E, Wernig M, Hanna JH, Hochedlinger K, Pei D, Jaenisch R, Deng H, Orkin SH, Park PJ, Daley GQ. Failure to replicate the STAP cell phenomenon. Nature. 2015 Sep 24; 525(7570):E6-9. PMID: 26399835.
    View in: PubMed
  30. Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. PMID: 26385351; PMCID: PMC4692141 [Available on 12/24/16].
  31. Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, Loh YH. Systematic identification of factors for provirus silencing in embryonic stem cells. Cell. 2015 Sep 24; 163(1):230-45. PMID: 26365490; PMCID: PMC4686136.
  32. Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2015 Sep 01; 12(9):1456-70. PMID: 26299972.
    View in: PubMed
  33. Soria-Valles C, Osorio FG, Gutiérrez-Fernández A, De Los Angeles A, Bueno C, Menéndez P, Martín-Subero JI, Daley GQ, Freije JM, López-Otín C. NF-?B activation impairs somatic cell reprogramming in ageing. Nat Cell Biol. 2015 Aug; 17(8):1004-13. PMID: 26214134.
    View in: PubMed
  34. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000. PMID: 26211600.
    View in: PubMed
  35. Li P, Lahvic JL, Binder V, Pugach EK, Riley EB, Tamplin OJ, Panigrahy D, Bowman TV, Barrett FG, Heffner GC, McKinney-Freeman S, Schlaeger TM, Daley GQ, Zeldin DC, Zon LI. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2015 Jul 23; 523(7561):468-71. PMID: 26201599; PMCID: PMC4754787.
  36. Cacchiarelli D, Trapnell C, Ziller MJ, Soumillon M, Cesana M, Karnik R, Donaghey J, Smith ZD, Ratanasirintrawoot S, Zhang X, Ho Sui SJ, Wu Z, Akopian V, Gifford CA, Doench J, Rinn JL, Daley GQ, Meissner A, Lander ES, Mikkelsen TS. Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell. 2015 Jul 16; 162(2):412-24. PMID: 26186193; PMCID: PMC4511597.
  37. Singbrant S, van Galen P, Lucas D, Challen G, Rossi DJ, Daley GQ. Two new routes to make blood: Hematopoietic specification from pluripotent cell lines versus reprogramming of somatic cells. Exp Hematol. 2015 Sep; 43(9):756-9. PMID: 26143581.
    View in: PubMed
  38. Abed S, Tubsuwan A, Chaichompoo P, Park IH, Pailleret A, Benyoucef A, Tosca L, De Dreuzy E, Paulard A, Granger-Locatelli M, Relouzat F, Prost S, Tachdjian G, Fucharoen S, Daley GQ, Payen E, Chrétien S, Leboulch P, Maouche-Chrétien L. Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice. Haematologica. 2015 Oct; 100(10):e428-31. PMID: 26088930; PMCID: PMC4591782.
  39. Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, Ku YC, Chen SC, Viswanathan SR, Zhu H, Nishihara R, Inamura K, Kim SA, Morikawa T, Mima K, Sukawa Y, Yang J, Meredith G, Fuchs CS, Ogino S, Daley GQ. LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev. 2015 May 15; 29(10):1074-86. PMID: 25956904; PMCID: PMC4441054.
  40. Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice. PLoS One. 2015; 10(5):e0125947. PMID: 25950705; PMCID: PMC4423907.
  41. Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. PMID: 25870201; PMCID: PMC4419355.
  42. Diaz MF, Li N, Lee HJ, Adamo L, Evans SM, Willey HE, Arora N, Torisawa YS, Vickers DA, Morris SA, Naveiras O, Murthy SK, Ingber DE, Daley GQ, García-Cardeña G, Wenzel PL. Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp Med. 2015 May 04; 212(5):665-80. PMID: 25870199; PMCID: PMC4419354.
  43. Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 04; 212(5):649-63. PMID: 25870200; PMCID: PMC4419349.
  44. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science. 2015 Apr 03; 348(6230):36-8. PMID: 25791083; PMCID: PMC4394183.
  45. Vo LT, Daley GQ. De novo generation of HSCs from somatic and pluripotent stem cell sources. Blood. 2015 Apr 23; 125(17):2641-8. PMID: 25762177; PMCID: PMC4408289.
  46. Shyh-Chang N, Daley GQ. Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metab. 2015 Mar 03; 21(3):349-50. PMID: 25738450.
    View in: PubMed
  47. Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu H, DeAngelo DJ, Daley GQ, Wagers AJ. The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Leukemia. 2015 Jun; 29(6):1320-30. PMID: 25655194; PMCID: PMC4456252.
  48. Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Do EK, Kim JH, Schlaeger TM, Zon LI, Bigas A, Burns CE, Daley GQ. Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 2015 Feb 26; 125(9):1418-26. PMID: 25587036; PMCID: PMC4342355.
  49. Daley GQ. Dissecting reprogramming, differentiation and conversion with network biology. Leuk Suppl. 2014 Dec; 3(Suppl 1):S3-4. PMID: 27175271; PMCID: PMC4851278.
  50. Kumar RM, Cahan P, Shalek AK, Satija R, DaleyKeyser AJ, Li H, Zhang J, Pardee K, Gennert D, Trombetta JJ, Ferrante TC, Regev A, Daley GQ, Collins JJ. Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature. 2014 Dec 04; 516(7529):56-61. PMID: 25471879; PMCID: PMC4256722.
  51. Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. PMID: 25437882; PMCID: PMC4329913.
  52. Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. A nontranscriptional role for Oct4 in the regulation of mitotic entry. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15768-73. PMID: 25324523; PMCID: PMC4226071.
  53. Daley GQ. Deriving blood stem cells from pluripotent stem cells for research and therapy. Best Pract Res Clin Haematol. 2014 Sep-Dec; 27(3-4):293-7. PMID: 25455281.
    View in: PubMed
  54. Unternaehrer JJ, Zhao R, Kim K, Cesana M, Powers JT, Ratanasirintrawoot S, Onder T, Shibue T, Weinberg RA, Daley GQ. The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming. Stem Cell Reports. 2014 Nov 11; 3(5):691-8. PMID: 25316190; PMCID: PMC4235745.
  55. Fox IJ, Daley GQ, Goldman SA, Huard J, Kamp TJ, Trucco M. Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease. Science. 2014 Aug 22; 345(6199):1247391. PMID: 25146295; PMCID: PMC4329726.
  56. Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell. 2014 Aug 14; 158(4):889-902. PMID: 25126792; PMCID: PMC4291075.
  57. Cahan P, Li H, Morris SA, Lummertz da Rocha E, Daley GQ, Collins JJ. CellNet: network biology applied to stem cell engineering. Cell. 2014 Aug 14; 158(4):903-15. PMID: 25126793; PMCID: PMC4233680.
  58. Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, Comerford SA, Ramezani S, Sun X, Parikh MS, Yang EH, Powers JT, Shinoda G, Shah SP, Hammer RE, Daley GQ, Zhu H. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell. 2014 Aug 11; 26(2):248-61. PMID: 25117712; PMCID: PMC4145706.
  59. Arora N, Wenzel PL, McKinney-Freeman SL, Ross SJ, Kim PG, Chou SS, Yoshimoto M, Yoder MC, Daley GQ. Effect of developmental stage of HSC and recipient on transplant outcomes. Dev Cell. 2014 Jun 09; 29(5):621-8. PMID: 24914562; PMCID: PMC4172398.
  60. Lu Y, Loh YH, Li H, Cesana M, Ficarro SB, Parikh JR, Salomonis N, Toh CX, Andreadis ST, Luckey CJ, Collins JJ, Daley GQ, Marto JA. Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. Cell Stem Cell. 2014 Jul 03; 15(1):92-101. PMID: 24813856; PMCID: PMC4082735.
  61. Sumer H, Kim K, Liu J, Ng K, Daley GQ, Verma PJ. Functional evaluation of ES-somatic cell hybrids in vitro and in vivo. Cell Reprogram. 2014 Jun; 16(3):167-74. PMID: 24787484; PMCID: PMC4030652.
  62. Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014 May 01; 28(9):971-82. PMID: 24732380; PMCID: PMC4018495.
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  231. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007 Jun 21; 447(7147):1007-11. PMID: 17581586; PMCID: PMC2775137.
  232. Raz T, Nardi V, Azam M, Cortes J, Daley GQ. Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood. 2007 Sep 15; 110(6):2102-9. PMID: 17536018; PMCID: PMC1976354.
  233. Daley GQ. Gametes from embryonic stem cells: a cup half empty or half full? Science. 2007 Apr 20; 316(5823):409-10. PMID: 17446394.
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  234. Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA. The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 2007 Jul 01; 110(1):171-9. PMID: 17392504; PMCID: PMC1896110.
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  237. Lengerke C, McKinney-Freeman S, Naveiras O, Yates F, Wang Y, Bansal D, Daley GQ. The cdx-hox pathway in hematopoietic stem cell formation from embryonic stem cells. Ann N Y Acad Sci. 2007 Jun; 1106:197-208. PMID: 17303828.
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  238. Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J, Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L. Ethics. The ISSCR guidelines for human embryonic stem cell research. Science. 2007 Feb 02; 315(5812):603-4. PMID: 17272706.
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  239. Daley GQ. Towards the generation of patient-specific pluripotent stem cells for combined gene and cell therapy of hematologic disorders. Hematology Am Soc Hematol Educ Program. 2007; 17-22. PMID: 18024604.
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  240. Kim K, Lerou P, Yabuuchi A, Lengerke C, Ng K, West J, Kirby A, Daly MJ, Daley GQ. Histocompatible embryonic stem cells by parthenogenesis. Science. 2007 Jan 26; 315(5811):482-6. PMID: 17170255.
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  241. Bansal D, Scholl C, Fröhling S, McDowell E, Lee BH, Döhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16924-9. PMID: 17068127; PMCID: PMC1636555.
  242. Yates F, Daley GQ. Progress and prospects: gene transfer into embryonic stem cells. Gene Ther. 2006 Oct; 13(20):1431-9. PMID: 17016468.
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  243. Azam M, Nardi V, Shakespeare WC, Metcalf CA, Bohacek RS, Wang Y, Sundaramoorthi R, Sliz P, Veach DR, Bornmann WG, Clarkson B, Dalgarno DC, Sawyer TK, Daley GQ. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9244-9. PMID: 16754879; PMCID: PMC1482597.
  244. Naveiras O, Daley GQ. Stem cells and their niche: a matter of fate. Cell Mol Life Sci. 2006 Apr; 63(7-8):760-6. PMID: 16568245.
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  245. Borthakur G, Kantarjian H, Daley G, Talpaz M, O'Brien S, Garcia-Manero G, Giles F, Faderl S, Sugrue M, Cortes J. Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy. Cancer. 2006 Jan 15; 106(2):346-52. PMID: 16342165.
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  246. Willey S, Ayuso-Sacido A, Zhang H, Fraser ST, Sahr KE, Adlam MJ, Kyba M, Daley GQ, Keller G, Baron MH. Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor. Blood. 2006 Apr 15; 107(8):3122-30. PMID: 16403910; PMCID: PMC1784910.
  247. Azam M, Daley GQ. Anticipating clinical resistance to target-directed agents : the BCR-ABL paradigm. Mol Diagn Ther. 2006; 10(2):67-76. PMID: 16669605.
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  248. Geijsen N, Daley GQ. Male germ cells. Methods Enzymol. 2006; 418:307-14. PMID: 17141043.
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  249. West JA, Park IH, Daley GQ, Geijsen N. In vitro generation of germ cells from murine embryonic stem cells. Nat Protoc. 2006; 1(4):2026-36. PMID: 17487192.
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  250. Zaehres H, Daley GQ. Transgene expression and RNA interference in embryonic stem cells. Methods Enzymol. 2006; 420:49-64. PMID: 17161693.
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  251. Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS. Novel role for PDEF in epithelial cell migration and invasion. Cancer Res. 2005 Dec 15; 65(24):11572-80. PMID: 16357167; PMCID: PMC2919290.
  252. Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19081-6. PMID: 16357205; PMCID: PMC1323159.
  253. Lensch MW, Daley GQ. Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells. Blood. 2006 Apr 01; 107(7):2605-12. PMID: 16332966; PMCID: PMC1895374.
  254. Lerou PH, Daley GQ. Therapeutic potential of embryonic stem cells. Blood Rev. 2005 Nov; 19(6):321-31. PMID: 16275420.
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  255. Lengerke C, Daley GQ. Patterning definitive hematopoietic stem cells from embryonic stem cells. Exp Hematol. 2005 Sep; 33(9):971-9. PMID: 16140144.
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  256. Daley GQ. Customized human embryonic stem cells. Nat Biotechnol. 2005 Jul; 23(7):826-8. PMID: 16003368.
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  257. Barnes K, McIntosh E, Whetton AD, Daley GQ, Bentley J, Baldwin SA. Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene. 2005 May 05; 24(20):3257-67. PMID: 15735728.
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  259. Kubo A, Chen V, Kennedy M, Zahradka E, Daley GQ, Keller G. The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation. Blood. 2005 Jun 15; 105(12):4590-7. PMID: 15728128; PMCID: PMC1895005.
  260. Weisberg E, Manley PW, Breitenstein W, Brüggen J, Cowan-Jacob SW, Ray A, Huntly B, Fabbro D, Fendrich G, Hall-Meyers E, Kung AL, Mestan J, Daley GQ, Callahan L, Catley L, Cavazza C, Azam M, Mohammed A, Neuberg D, Wright RD, Gilliland DG, Griffin JD. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell. 2005 Feb; 7(2):129-41. PMID: 15710326.
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  261. Ting DT, Kyba M, Daley GQ. Inducible transgene expression in mouse stem cells. Methods Mol Med. 2005; 105:23-46. PMID: 15492386.
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  262. Daley GQ, Sandel MJ, Moreno JD. Stem cell research: science, ethics and policy. Med Ethics (Burlingt Mass). 2005; 12(1):5. PMID: 15856604.
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  263. Melton DA, Daley GQ, Jennings CG. Altered nuclear transfer in stem-cell research - a flawed proposal. N Engl J Med. 2004 Dec 30; 351(27):2791-2. PMID: 15625329.
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  264. West JA, Daley GQ. In vitro gametogenesis from embryonic stem cells. Curr Opin Cell Biol. 2004 Dec; 16(6):688-92. PMID: 15530782.
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  265. Daley GQ. Chronic myeloid leukemia: proving ground for cancer stem cells. Cell. 2004 Oct 29; 119(3):314-6. PMID: 15507204.
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  266. Woolf PJ, Prudhomme W, Daheron L, Daley GQ, Lauffenburger DA. Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. Bioinformatics. 2005 Mar; 21(6):741-53. PMID: 15479714.
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  267. Daley GQ. Missed opportunities in embryonic stem-cell research. N Engl J Med. 2004 Aug 12; 351(7):627-8. PMID: 15302910.
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  268. Daley GQ. Alchemy in the liver: fact or fusion? Nat Med. 2004 Jul; 10(7):671-2. PMID: 15229507.
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  269. Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 2004 Jun 03; 23(26):4641-5. PMID: 15064711.
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  270. Snyder EY, Daley GQ, Goodell M. Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system. J Neurosci Res. 2004 Apr 15; 76(2):157-68. PMID: 15048913.
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  271. Prudhomme W, Daley GQ, Zandstra P, Lauffenburger DA. Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2900-5. PMID: 14978270; PMCID: PMC365717.
  272. Koh EY, Chen T, Daley GQ. Genetic complementation of cytokine signaling identifies central role of kinases in hematopoietic cell proliferation. Oncogene. 2004 Feb 12; 23(6):1214-20. PMID: 14647454.
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  273. Dahéron L, Opitz SL, Zaehres H, Lensch MW, Lensch WM, Andrews PW, Itskovitz-Eldor J, Daley GQ. LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells. 2004; 22(5):770-8. PMID: 15342941.
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  274. Lensch MW, Daley GQ. Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models. Curr Top Dev Biol. 2004; 60:127-96. PMID: 15094298.
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  275. Nardi V, Azam M, Daley GQ. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol. 2004 Jan; 11(1):35-43. PMID: 14676625.
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  276. Hochedlinger K, Rideout WM, Kyba M, Daley GQ, Blelloch R, Jaenisch R. Nuclear transplantation, embryonic stem cells and the potential for cell therapy. Hematol J. 2004; 5 Suppl 3:S114-7. PMID: 15190291.
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  277. Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ. Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature. 2004 Jan 08; 427(6970):148-54. PMID: 14668819.
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  278. Larson RA, Daley GQ, Schiffer CA, Porcu P, Pui CH, Marie JP, Steelman LS, Bertrand FE, McCubrey JA. Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002. Leukemia. 2003 Dec; 17(12):2358-82. PMID: 14562120.
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  279. Kyba M, Daley GQ. Hematopoiesis from embryonic stem cells: lessons from and for ontogeny. Exp Hematol. 2003 Nov; 31(11):994-1006. PMID: 14585361.
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  280. Azam M, Raz T, Nardi V, Opitz SL, Daley GQ. A screen to identify drug resistant variants to target-directed anti-cancer agents. Biol Proced Online. 2003; 5:204-210. PMID: 14615817.
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  281. Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003 Sep 18; 425(6955):300-6. PMID: 13679919.
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  282. Kyba M, Perlingeiro RC, Hoover RR, Lu CW, Pierce J, Daley GQ. Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11904-10. PMID: 12930895; PMCID: PMC304105.
  283. Daley GQ. Cloning and stem cells--handicapping the political and scientific debates. N Engl J Med. 2003 Jul 17; 349(3):211-2. PMID: 12867604.
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  284. Daley GQ. ES cells prove egg-straordinary. Nat Biotechnol. 2003 Jul; 21(7):760-1. PMID: 12833097.
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  285. Daley GQ. Gleevec resistance: lessons for target-directed drug development. Cell Cycle. 2003 May-Jun; 2(3):190-1. PMID: 12734421.
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  286. Daley GQ. From embryos to embryoid bodies: generating blood from embryonic stem cells. Ann N Y Acad Sci. 2003 May; 996:122-31. PMID: 12799290.
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  287. Daley GQ. Towards combination target-directed chemotherapy for chronic myeloid leukemia: role of farnesyl transferase inhibitors. Semin Hematol. 2003 Apr; 40(2 Suppl 2):11-4. PMID: 12783369.
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  288. Azam M, Latek RR, Daley GQ. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell. 2003 Mar 21; 112(6):831-43. PMID: 12654249.
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  289. Perlingeiro RC, Kyba M, Bodie S, Daley GQ. A role for thrombopoietin in hemangioblast development. Stem Cells. 2003; 21(3):272-80. PMID: 12743322.
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  290. Daley GQ, Goodell MA, Snyder EY. Realistic prospects for stem cell therapeutics. Hematology Am Soc Hematol Educ Program. 2003; 398-418. PMID: 14633792.
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  291. Daley GQ. Dodging the magic bullet: understanding imatinib resistance. Cancer Biol Ther. 2003 Jan-Feb; 2(1):109-10. PMID: 12673130.
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  292. Kyba M, Perlingeiro RC, Daley GQ. Development of hematopoietic repopulating cells from embryonic stem cells. Methods Enzymol. 2003; 365:114-29. PMID: 14696341.
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  293. Koh EY, Chen T, Daley GQ. Novel retroviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res. 2002 Dec 15; 30(24):e142. PMID: 12490733; PMCID: PMC140091.
  294. Daley GQ. Prospects for stem cell therapeutics: myths and medicines. Curr Opin Genet Dev. 2002 Oct; 12(5):607-13. PMID: 12200167.
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  295. Hoover RR, Mahon FX, Melo JV, Daley GQ. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood. 2002 Aug 01; 100(3):1068-71. PMID: 12130526.
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  296. Dang SM, Kyba M, Perlingeiro R, Daley GQ, Zandstra PW. Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems. Biotechnol Bioeng. 2002 May 20; 78(4):442-53. PMID: 11948451.
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  297. Rideout WM, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell. 2002 Apr 05; 109(1):17-27. PMID: 11955443.
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  298. Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 2002 Apr 05; 109(1):29-37. PMID: 11955444.
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  299. Shvarts A, Brummelkamp TR, Scheeren F, Koh E, Daley GQ, Spits H, Bernards R. A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes Dev. 2002 Mar 15; 16(6):681-6. PMID: 11914273; PMCID: PMC155362.
  300. Peeper DS, Shvarts A, Brummelkamp T, Douma S, Koh EY, Daley GQ, Bernards R. A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence. Nat Cell Biol. 2002 Feb; 4(2):148-53. PMID: 11812999.
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  301. Jena N, Deng M, Sicinska E, Sicinski P, Daley GQ. Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells. Cancer Res. 2002 Jan 15; 62(2):535-41. PMID: 11809706.
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  302. Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedman M, Metivier J, Cannata R, O'Donnell CJ, Kottke-Marchant K, Murugesan G, Plow EF, Stenina O, Daley GQ. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation. 2001 Nov 27; 104(22):2641-4. PMID: 11723011.
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  303. Perlingeiro RC, Kyba M, Daley GQ. Clonal analysis of differentiating embryonic stem cells reveals a hematopoietic progenitor with primitive erythroid and adult lymphoid-myeloid potential. Development. 2001 Nov; 128(22):4597-604. PMID: 11714684.
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  304. Hoover RR, Gerlach MJ, Koh EY, Daley GQ. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. Oncogene. 2001 Sep 13; 20(41):5826-35. PMID: 11593388.
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  305. Deng M, Daley GQ. Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia. Blood. 2001 Jun 01; 97(11):3491-7. PMID: 11369642.
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  306. Peters DG, Klucher KM, Perlingeiro RC, Dessain SK, Koh EY, Daley GQ. Autocrine and paracrine effects of an ES-cell derived, BCR/ABL-transformed hematopoietic cell line that induces leukemia in mice. Oncogene. 2001 May 10; 20(21):2636-46. PMID: 11420675.
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  307. Reichert A, Heisterkamp N, Daley GQ, Groffen J. Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood. 2001 Mar 01; 97(5):1399-403. PMID: 11222386.
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  308. Peters DG, Hoover RR, Gerlach MJ, Koh EY, Zhang H, Choe K, Kirschmeier P, Bishop WR, Daley GQ. Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood. 2001 Mar 01; 97(5):1404-12. PMID: 11222387.
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  309. Daley GQ, Cargill M. The heart SNPs a beat: polymorphisms in candidate genes for cardiovascular disease. Trends Cardiovasc Med. 2001 Feb; 11(2):60-6. PMID: 11530294.
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  310. Jacobs JJ, Keblusek P, Robanus-Maandag E, Kristel P, Lingbeek M, Nederlof PM, van Welsem T, van de Vijver MJ, Koh EY, Daley GQ, van Lohuizen M. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nat Genet. 2000 Nov; 26(3):291-9. PMID: 11062467.
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  311. Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA. Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnol Bioeng. 2000 Sep 20; 69(6):607-17. PMID: 10918135.
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  312. Berns K, Hijmans EM, Koh E, Daley GQ, Bernards R. A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts. Oncogene. 2000 Jul 06; 19(29):3330-4. PMID: 10918589.
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  313. Cargill M, Daley GQ. Mining for SNPs: putting the common variants--common disease hypothesis to the test. Pharmacogenomics. 2000 Feb; 1(1):27-37. PMID: 11258594.
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  314. Salgia R, Quackenbush E, Lin J, Souchkova N, Sattler M, Ewaniuk DS, Klucher KM, Daley GQ, Kraeft SK, Sackstein R, Alyea EP, von Andrian UH, Chen LB, Gutierrez-Ramos JC, Pendergast AM, Griffin JD. The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. Blood. 1999 Dec 15; 94(12):4233-46. PMID: 10590068.
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  315. Ghaffari S, Wu H, Gerlach M, Han Y, Lodish HF, Daley GQ. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13186-90. PMID: 10557295; PMCID: PMC23922.
  316. Ghaffari S, Daley GQ, Lodish HF. Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays. Leukemia. 1999 Aug; 13(8):1200-6. PMID: 10450747.
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  317. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999 Jul; 22(3):231-8. PMID: 10391209.
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  318. Li S, Ilaria RL, Million RP, Daley GQ, Van Etten RA. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med. 1999 May 03; 189(9):1399-412. PMID: 10224280; PMCID: PMC2193055.
  319. Ross RK, Coetzee GA, Pearce CL, Reichardt JK, Bretsky P, Kolonel LN, Henderson BE, Lander E, Altshuler D, Daley G. Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility. Eur Urol. 1999; 35(5-6):355-61. PMID: 10325489.
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  320. Socolovsky M, Lodish HF, Daley GQ. Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):6573-5. PMID: 9618452; PMCID: PMC33861.
  321. Klucher KM, Lopez DV, Daley GQ. Secondary mutation maintains the transformed state in BaF3 cells with inducible BCR/ABL expression. Blood. 1998 May 15; 91(10):3927-34. PMID: 9573031.
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  322. Murray PJ, Young RA, Daley GQ. Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria. Blood. 1998 Apr 15; 91(8):2914-24. PMID: 9531602.
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  323. Klucher KM, Gerlach MJ, Daley GQ. A novel method to isolate cells with conditional gene expression using fluorescence activated cell sorting. Nucleic Acids Res. 1997 Dec 01; 25(23):4858-60. PMID: 9365269; PMCID: PMC147116.
  324. Daley GQ. Rationalizing autotransplant strategies for chronic myeloid leukemia. Leuk Lymphoma. 1996 May; 21(5-6):353-8. PMID: 9172799.
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  325. Daley GQ. Genetic events in CML: from translocation to transplantation. Bone Marrow Transplant. 1994; 14 Suppl 3:S5-9. PMID: 7697009.
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  326. Daley GQ, Goldman JM. Autologous transplant for CML revisited. Exp Hematol. 1993 Jun; 21(6):734-7. PMID: 8500574.
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  328. Daley GQ, Van Etten RA, Jackson PK, Bernards A, Baltimore D. Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line. Mol Cell Biol. 1992 Apr; 12(4):1864-71. PMID: 1549131; PMCID: PMC369630.
  329. Daley GQ, Van Etten RA, Baltimore D. Blast crisis in a murine model of chronic myelogenous leukemia. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11335-8. PMID: 1763047; PMCID: PMC53129.
  330. Scott ML, Van Etten RA, Daley GQ, Baltimore D. v-abl causes hematopoietic disease distinct from that caused by bcr-abl. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6506-10. PMID: 1862078; PMCID: PMC52114.
  331. Varticovski L, Daley GQ, Jackson P, Baltimore D, Cantley LC. Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants. Mol Cell Biol. 1991 Feb; 11(2):1107-13. PMID: 1846663; PMCID: PMC359788.
  332. Daley GQ, Ben-Neriah Y. Implicating the bcr/abl gene in the pathogenesis of Philadelphia chromosome-positive human leukemia. Adv Cancer Res. 1991; 57:151-84. PMID: 1950703.
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  333. Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science. 1990 Feb 16; 247(4944):824-30. PMID: 2406902.
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  334. Taj AS, Martiat P, Dhut S, Chaplin TL, Dowding C, Th'ng KH, Goldstein I, Daley GQ, Young BD, Goldman JM. Inhibition of P210BCR/ABL Expression in K562 Cells by Electroporation with an Antisense Oligonucleotide. Leuk Lymphoma. 1990; 3(3):201-8. PMID: 27457438.
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  335. Daley GQ, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9312-6. PMID: 3143116; PMCID: PMC282729.
  336. Daley GQ, McLaughlin J, Witte ON, Baltimore D. The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts. Science. 1987 Jul 31; 237(4814):532-5. PMID: 2440107.
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  337. Mes-Masson AM, McLaughlin J, Daley GQ, Paskind M, Witte ON. Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome. Proc Natl Acad Sci U S A. 1986 Dec; 83(24):9768-72. PMID: 3540951; PMCID: PMC387222.
  338. Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. 1986 Jul 11; 233(4760):212-4. PMID: 3460176.
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  339. Ben-Neriah Y, Bernards A, Paskind M, Daley GQ, Baltimore D. Alternative 5' exons in c-abl mRNA. Cell. 1986 Feb 28; 44(4):577-86. PMID: 3512096.
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  340. Foster DA, Levy JB, Daley GQ, Simon MC, Hanafusa H. Isolation of chicken cellular DNA sequences with homology to the region of viral oncogenes that encodes the tyrosine kinase domain. Mol Cell Biol. 1986 Jan; 6(1):325-31. PMID: 3023834; PMCID: PMC367515.
  341. Taylor DL, Heiple J, Wang YL, Luna EJ, Tanasugarn L, Brier J, Swanson J, Fechheimer M, Amato P, Rockwell M, Daley G. Cellular and molecular aspects of amoeboid movement. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 1:101-11. PMID: 6286211.
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