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William Alan Copen, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Winzeck S, Mocking SJT, Bezerra R, Bouts MJRJ, McIntosh EC, Diwan I, Garg P, Chutinet A, Kimberly WT, Copen WA, Schaefer PW, Ay H, Singhal AB, Kamnitsas K, Glocker B, Sorensen AG, Wu O. Ensemble of Convolutional Neural Networks Improves Automated Segmentation of Acute Ischemic Lesions Using Multiparametric Diffusion-Weighted MRI. AJNR Am J Neuroradiol. 2019 May 30. PMID: 31147354.
  2. Etherton MR, Wu O, Giese AK, Lauer A, Boulouis G, Mills B, Cloonan L, Donahue KL, Copen W, Schaefer P, Rost NS. White Matter Integrity and Early Outcomes After Acute Ischemic Stroke. Transl Stroke Res. 2019 Jan 28. PMID: 30693424.
    Citations:    Fields:    
  3. Schwamm LH, Wu O, Song SS, Latour LL, Ford AL, Hsia AW, Muzikansky A, Betensky RA, Yoo AJ, Lev MH, Boulouis G, Lauer A, Cougo P, Copen WA, Harris GJ, Warach S. Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results. Ann Neurol. 2018 May; 83(5):980-993. PMID: 29689135.
    Citations: 1     Fields:    
  4. Copen WA, Yoo AJ, Rost NS, Morais LT, Schaefer PW, González RG, Wu O. In patients with suspected acute stroke, CT perfusion-based cerebral blood flow maps cannot substitute for DWI in measuring the ischemic core. PLoS One. 2017; 12(11):e0188891. PMID: 29190675.
    Citations: 1     Fields:    Translation:Humans
  5. Rost NS, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJ, Lauer A, Etherton MR, Karadeli HH, Musolino PL, Copen WA, Arai K, Lo EH, Feske SK, Furie KL, Wu O. Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab. 2018 01; 38(1):75-86. PMID: 28481164.
    Citations:    Fields:    Translation:Humans
  6. Reda HM, Copen WA, Karaa A, Oakley DH. Case 13-2017. A 41-Year-Old Man with Hearing Loss, Seizures, Weakness, and Cognitive Decline. N Engl J Med. 2017 04 27; 376(17):1668-1678. PMID: 28445665.
    Citations:    Fields:    Translation:Humans
  7. Edlow BL, Copen WA, Izzy S, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Longitudinal Diffusion Tensor Imaging Detects Recovery of Fractional Anisotropy Within Traumatic Axonal Injury Lesions. Neurocrit Care. 2016 06; 24(3):342-52. PMID: 26690938.
    Citations: 3     Fields:    Translation:Humans
  8. Edlow BL, Copen WA, Izzy S, Bakhadirov K, van der Kouwe A, Glenn MB, Greenberg SM, Greer DM, Wu O. Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis. BMC Neurol. 2016 Jan 11; 16:2. PMID: 26754948.
    Citations: 8     Fields:    Translation:Humans
  9. Copen WA, Lev MH, Rapalino O. Brain perfusion: computed tomography and magnetic resonance techniques. Handb Clin Neurol. 2016; 135:117-135. PMID: 27432662.
    Citations: 1     Fields:    Translation:Humans
  10. Hirai KK, Groisser BN, Copen WA, Singhal AB, Schaechter JD. Comparing prognostic strength of acute corticospinal tract injury measured by a new diffusion tensor imaging based template approach versus common approaches. J Neurosci Methods. 2016 Jan 15; 257:204-13. PMID: 26386285.
    Citations: 1     Fields:    Translation:Humans
  11. Wu O, Cloonan L, Mocking SJ, Bouts MJ, Copen WA, Cougo-Pinto PT, Fitzpatrick K, Kanakis A, Schaefer PW, Rosand J, Furie KL, Rost NS. Role of Acute Lesion Topography in Initial Ischemic Stroke Severity and Long-Term Functional Outcomes. Stroke. 2015 Sep; 46(9):2438-44. PMID: 26199314.
    Citations: 15     Fields:    Translation:Humans
  12. Copen WA, Morais LT, Wu O, Schwamm LH, Schaefer PW, González RG, Yoo AJ. In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core? PLoS One. 2015; 10(7):e0133566. PMID: 26193486.
    Citations: 5     Fields:    Translation:Humans
  13. Copen WA. Multimodal imaging in acute ischemic stroke. Curr Treat Options Cardiovasc Med. 2015 Mar; 17(3):368. PMID: 25732923.
    Citations: 2     
  14. Copen WA, Deipolyi AR, Schaefer PW, Schwamm LH, González RG, Wu O. Exposing hidden truncation-related errors in acute stroke perfusion imaging. AJNR Am J Neuroradiol. 2015 Apr; 36(4):638-45. PMID: 25500309.
    Citations: 2     Fields:    Translation:Humans
  15. Mehan WA, González RG, Buchbinder BR, Chen JW, Copen WA, Gupta R, Hirsch JA, Hunter GJ, Hunter S, Johnson JM, Kelly HR, Larvie M, Lev MH, Pomerantz SR, Rapalino O, Rincon S, Romero JM, Schaefer PW, Shah V. Optimal brain MRI protocol for new neurological complaint. PLoS One. 2014; 9(10):e110803. PMID: 25343371.
    Citations:    Fields:    Translation:Humans
  16. Schaefer PW, Pulli B, Copen WA, Hirsch JA, Leslie-Mazwi T, Schwamm LH, Wu O, González RG, Yoo AJ. Combining MRI with NIHSS thresholds to predict outcome in acute ischemic stroke: value for patient selection. AJNR Am J Neuroradiol. 2015 Feb; 36(2):259-64. PMID: 25258369.
    Citations: 6     Fields:    Translation:Humans
  17. Hakimelahi R, Vachha BA, Copen WA, Papini GD, He J, Higazi MM, Lev MH, Schaefer PW, Yoo AJ, Schwamm LH, González RG. Time and diffusion lesion size in major anterior circulation ischemic strokes. Stroke. 2014 Oct; 45(10):2936-41. PMID: 25190444.
    Citations: 9     Fields:    Translation:Humans
  18. Groisser BN, Copen WA, Singhal AB, Hirai KK, Schaechter JD. Corticospinal tract diffusion abnormalities early after stroke predict motor outcome. Neurorehabil Neural Repair. 2014 Oct; 28(8):751-60. PMID: 24519021.
    Citations: 20     Fields:    Translation:Humans
  19. Ruff IM, Ali SF, Goldstein JN, Lev M, Copen WA, McIntyre J, Rost NS, Schwamm LH. Improving door-to-needle times: a single center validation of the target stroke hypothesis. Stroke. 2014 Feb; 45(2):504-8. PMID: 24399372.
    Citations: 10     Fields:    Translation:Humans
  20. Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, Grotta JC, Houser G, Jovin TG, Lees KR, Lev MH, Liebeskind DS, Luby M, Muir KW, Parsons MW, von Kummer R, Wardlaw JM, Wu O, Yoo AJ, Alexandrov AV, Alger JR, Aviv RI, Bammer R, Baron JC, Calamante F, Campbell BC, Carpenter TC, Christensen S, Copen WA, Derdeyn CP, Haley EC, Khatri P, Kudo K, Lansberg MG, Latour LL, Lee TY, Leigh R, Lin W, Lyden P, Mair G, Menon BK, Michel P, Mikulik R, Nogueira RG, Ostergaard L, Pedraza S, Riedel CH, Rowley HA, Sanelli PC, Sasaki M, Saver JL, Schaefer PW, Schellinger PD, Tsivgoulis G, Wechsler LR, White PM, Zaharchuk G, Zaidat OO, Davis SM, Donnan GA, Furlan AJ, Hacke W, Kang DW, Kidwell C, Thijs VN, Thomalla G, Warach SJ. Acute Stroke Imaging Research Roadmap II. Stroke. 2013 Sep; 44(9):2628-39. PMID: 23860298.
    Citations: 36     Fields:    Translation:Humans
  21. González RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR, Larvie M, Hirsch JA, Gupta R. The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. J Neurointerv Surg. 2013 May; 5 Suppl 1:i7-12. PMID: 23493340.
    Citations: 16     Fields:    Translation:Humans
  22. Nogueira RG, Bayrlee A, Hirsch JA, Yoo AJ, Copen WA. Dynamic contrast-enhanced MRA at 1.5 T for detection of arteriovenous shunting before and after Onyx embolization of cerebral arteriovenous malformations. J Neuroimaging. 2013 Oct; 23(4):514-7. PMID: 23317169.
    Citations: 2     Fields:    Translation:Humans
  23. Deipolyi AR, Wu O, Macklin EA, Schaefer PW, Schwamm LH, Gilberto Gonzalez R, Copen WA. Reliability of cerebral blood volume maps as a substitute for diffusion-weighted imaging in acute ischemic stroke. J Magn Reson Imaging. 2012 Nov; 36(5):1083-7. PMID: 22761110.
    Citations: 8     Fields:    Translation:Humans
  24. Danagoulian GS, Qin L, Nayak KS, Colen RR, Mukundan S, Harris MB, Jolesz FA, Shankaranarayanan A, Copen WA, Schmidt EJ. Comparison of wideband steady-state free precession and T2-weighted fast spin echo in spine disorder assessment at 1.5 and 3 T. Magn Reson Med. 2012 Nov; 68(5):1527-35. PMID: 22287191.
    Citations: 2     Fields:    Translation:Humans
  25. Chow FC, Edlow BL, Frosch MP, Copen WA, Greer DM. Outcome in patients with H1N1 influenza and cerebrovascular injury treated with extracorporeal membrane oxygenation. Neurocrit Care. 2011 Aug; 15(1):156-60. PMID: 21465323.
    Citations: 7     Fields:    Translation:HumansCells
  26. Copen WA, Schaefer PW, Wu O. MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am. 2011 May; 21(2):259-83, x. PMID: 21640299.
    Citations: 23     Fields:    Translation:Humans
  27. Schanker BD, Walcott BP, Nahed BV, Ogilvy CS, Kiruluta AJ, Rabinov JD, Copen WA. Time-resolved contrast-enhanced magnetic resonance angiography in the investigation of suspected intracranial dural arteriovenous fistula. J Clin Neurosci. 2011 Jun; 18(6):837-9. PMID: 21504849.
    Citations: 5     Fields:    Translation:Humans
  28. Mui K, Yoo AJ, Verduzco L, Copen WA, Hirsch JA, González RG, Schaefer PW. Cerebral blood flow thresholds for tissue infarction in patients with acute ischemic stroke treated with intra-arterial revascularization therapy depend on timing of reperfusion. AJNR Am J Neuroradiol. 2011 May; 32(5):846-51. PMID: 21474633.
    Citations: 6     Fields:    Translation:Humans
  29. Sun PZ, Benner T, Copen WA, Sorensen AG. Early experience of translating pH-weighted MRI to image human subjects at 3 Tesla. Stroke. 2010 Oct; 41(10 Suppl):S147-51. PMID: 20876492.
    Citations: 32     Fields:    Translation:HumansAnimals
  30. Yoo AJ, Barak ER, Copen WA, Kamalian S, Gharai LR, Pervez MA, Schwamm LH, González RG, Schaefer PW. Combining acute diffusion-weighted imaging and mean transmit time lesion volumes with National Institutes of Health Stroke Scale Score improves the prediction of acute stroke outcome. Stroke. 2010 Aug; 41(8):1728-35. PMID: 20595665.
    Citations: 30     Fields:    Translation:Humans
  31. Edlow BL, Wainger BJ, Frosch MP, Copen WA, Rathmell JP, Rost NS. Posterior circulation stroke after C1-C2 intraarticular facet steroid injection: evidence for diffuse microvascular injury. Anesthesiology. 2010 Jun; 112(6):1532-5. PMID: 20460995.
    Citations: 3     Fields:    Translation:Humans
  32. Pless ML, Chen YB, Copen WA, Frosch MP. Case records of the Massachusetts General Hospital. Case 9-2010. A 37-year-old woman with paresthesias and ataxia. N Engl J Med. 2010 Mar 25; 362(12):1129-38. PMID: 20335590.
    Citations: 3     Fields:    Translation:Humans
  33. Brass SD, Dinkin MJ, Williams Z, Krishnamoorthy KS, Copen WA, Freeman SH. Case Records of the Massachusetts General Hospital. Case 38-2009 - a 16-year-old boy with paroxysmal headaches and visual changes. N Engl J Med. 2009 Dec 10; 361(24):2367-78. PMID: 20007563.
    Citations:    Fields:    Translation:Humans
  34. Brass SD, Smith EE, Arboleda-Velasquez JF, Copen WA, Frosch MP. Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members. N Engl J Med. 2009 Apr 16; 360(16):1656-65. PMID: 19369672.
    Citations: 6     Fields:    Translation:Humans
  35. Copen WA, Rezai Gharai L, Barak ER, Schwamm LH, Wu O, Kamalian S, Gonzalez RG, Schaefer PW. Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion. Radiology. 2009 Mar; 250(3):878-86. PMID: 19164120.
    Citations: 23     Fields:    Translation:Humans
  36. Brass SD, Copen WA. Neurological disorders in pregnancy from a neuroimaging perspective. Semin Neurol. 2007 Nov; 27(5):411-24. PMID: 17940920.
    Citations:    Fields:    Translation:Humans
  37. Yamada K, Wu O, Gonzalez RG, Bakker D, Østergaard L, Copen WA, Weisskoff RM, Rosen BR, Yagi K, Nishimura T, Sorensen AG. Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy. Stroke. 2002 Jan; 33(1):87-94. PMID: 11779894.
    Citations: 29     Fields:    Translation:HumansCells
  38. Copen WA, Schwamm LH, González RG, Wu O, Harmath CB, Schaefer PW, Koroshetz WJ, Sorensen AG. Ischemic stroke: effects of etiology and patient age on the time course of the core apparent diffusion coefficient. Radiology. 2001 Oct; 221(1):27-34. PMID: 11568317.
    Citations: 18     Fields:    Translation:HumansCells
  39. Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging. Stroke. 2001 Apr; 32(4):933-42. PMID: 11283394.
    Citations: 53     Fields:    Translation:Humans
  40. Sorensen AG, Wu O, Copen WA, Davis TL, Gonzalez RG, Koroshetz WJ, Reese TG, Rosen BR, Wedeen VJ, Weisskoff RM. Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology. 1999 Sep; 212(3):785-92. PMID: 10478247.
    Citations: 53     Fields:    Translation:HumansCells
  41. Rordorf G, Koroshetz WJ, Copen WA, Gonzalez G, Yamada K, Schaefer PW, Schwamm LH, Ogilvy CS, Sorensen AG. Diffusion- and perfusion-weighted imaging in vasospasm after subarachnoid hemorrhage. Stroke. 1999 Mar; 30(3):599-605. PMID: 10066858.
    Citations: 19     Fields:    Translation:HumansCells
  42. Sorensen AG, Copen WA, Ostergaard L, Buonanno FS, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Koroshetz WJ. Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time. Radiology. 1999 Feb; 210(2):519-27. PMID: 10207439.
    Citations: 62     Fields:    Translation:Humans
  43. Schwamm LH, Koroshetz WJ, Sorensen AG, Wang B, Copen WA, Budzik R, Rordorf G, Buonanno FS, Schaefer PW, Gonzalez RG. Time course of lesion development in patients with acute stroke: serial diffusion- and hemodynamic-weighted magnetic resonance imaging. Stroke. 1998 Nov; 29(11):2268-76. PMID: 9804633.
    Citations: 68     Fields:    Translation:Humans
  44. Rordorf G, Koroshetz WJ, Copen WA, Cramer SC, Schaefer PW, Budzik RF, Schwamm LH, Buonanno F, Sorensen AG, Gonzalez G. Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI. Stroke. 1998 May; 29(5):939-43. PMID: 9596239.
    Citations: 24     Fields:    Translation:HumansCells
  45. Sorensen AG, Buonanno FS, Gonzalez RG, Schwamm LH, Lev MH, Huang-Hellinger FR, Reese TG, Weisskoff RM, Davis TL, Suwanwela N, Can U, Moreira JA, Copen WA, Look RB, Finklestein SP, Rosen BR, Koroshetz WJ. Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging. Radiology. 1996 May; 199(2):391-401. PMID: 8668784.
    Citations: 72     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.