Harvard Catalyst Profiles

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Christos Mantzoros, M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. I01CX000422 (MANTZOROS, CHRISTOS S) Apr 1, 2011 - Jun 30, 2015
    NIH
    Leptin Signaling in Humans
    Role: Principal Investigator
  2. K24DK081913 (MANTZOROS, CHRISTOS S) Sep 15, 2008 - Jun 30, 2021
    NIH
    Adipokine physiology
    Role: Principal Investigator
  3. R01DK079929 (MANTZOROS, CHRISTOS S) Jul 15, 2008 - Jun 30, 2014
    NIH
    The Role of Leptin in the Maintenance of a Reduced Body Weight
    Role: Principal Investigator
  4. R34HD048526 (MANTZOROS, CHRISTOS S) Aug 1, 2005 - Jul 31, 2006
    NIH
    Clinical trial of leptin for hypothalamic amenorrhea
    Role: Principal Investigator
  5. R01DK058785 (MANTZOROS, CHRISTOS S) Dec 1, 2000 - Nov 30, 2012
    NIH
    Role of leptin in the neuroendocrine response to fasting
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 763 total Publications Show all
  1. Ramirez-Cisneros A, Stefanakis K, Mantzoros CS. Apolipoprotein CIII correlates with lipoproteins in the fed state and is not regulated by leptin administration in states of hypoleptinemia induced by acute or chronic energy deficiency: Results from two randomised controlled trials. Diabetes Obes Metab. 2025 Jan 15. PMID: 39810632.
    Citations:
    Fields: EndEndocrinologyMetMetabolism
  2. Gianopoulos I, Mantzoros CS, Daskalopoulou SS. Adiponectin and Adiponectin Receptors in Atherosclerosis. Endocr Rev. 2025 Jan 10; 46(1):1-25. PMID: 39106421; PMCID: PMC11720176.
    Citations:
    Fields: EndEndocrinologyTranslation:HumansAnimalsCells
  3. Barovic M, Hahn JJ, Heinrich A, Adhikari T, Schwarz P, Mirtschink P, Funk A, Kabisch S, Pfeiffer AFH, Blüher M, Seissler J, Stefan N, Wagner R, Fritsche A, Jumpertz von Schwartzenberg R, Chlamydas S, Harb H, Mantzoros CS, Chavakis T, Schürmann A, Birkenfeld AL, Roden M, Solimena M, Bornstein SR, Perakakis N. Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year. Diabetes Care. 2025 Jan 02. PMID: 39746149.
    Citations:
    Fields: EndEndocrinology
  4. Kokkorakis M, Folkertsma P, Anagnostakis F, Sirotin N, Agarwal M, Shantouf R, Henning RH, Pijl H, Wolffenbuttel BHR, Bax JJ, Atsma DE, Castela Forte J, Mantzoros CS, van Dam S. Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools. EBioMedicine. 2025 Jan; 111:105518. PMID: 39724785; PMCID: PMC11732493.
    Citations:
    Fields: GenGenetics, MedicalMedMedicine (General)
  5. Karakasis P, Patoulias D, Fragakis N, Mantzoros CS. Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis. Metabolism. 2025 Mar; 164:156113. PMID: 39719170.
    Citations:
    Fields: MetMetabolism
  6. Zeng Q, Luo X, Chen X, Luo W, Li R, Yang S, Yang J, Shu X, Li Q, Hu J, Ma L, Mantzoros CS. Renin-independent aldosteronism and metabolic dysfunction-associated steatotic liver disease and cirrhosis: A genetic association study. Clin Nutr. 2025 Jan; 44:193-200. PMID: 39708461.
    Citations:
    Fields: NutNutritional Sciences
  7. Fan H, Kouvari M, Mingrone G, George J, Papatheodoridis G, Valenzuela-Vallejo L, Liu Z, Chen X, Zhang T, Mantzoros CS. Lipoprotein (a) in the Full Spectrum of MASLD; Evidence from Histologically and Genetically Characterized Cohorts. Clin Gastroenterol Hepatol. 2024 Dec 11. PMID: 39672249.
    Citations:
    Fields: GasGastroenterology
  8. Zhou XD, Chen QF, Yang W, Zuluaga M, Targher G, Byrne CD, Valenti L, Luo F, Katsouras CS, Thaher O, Misra A, Ataya K, Oviedo RJ, Pik-Shan Kong A, Alswat K, Lonardo A, Wong YJ, Abu-Abeid A, Al Momani H, Ali A, Molina GA, Szepietowski O, Jumaev NA, Kizilkaya MC, Viveiros O, Toro-Huamanchumo CJ, Yen Kok KY, Ospanov O, Abbas SI, Robertson AG, Fouad Y, Mantzoros CS, Zhang H, Méndez-Sánchez N, Sookoian S, Chan WK, Treeprasertsuk S, Adams L, Ocama P, Ryan JD, Perera N, Sharara AI, Al-Busafi SA, Opio CK, Garcia M, Lim-Loo MC, Ruiz-Úcar E, Prasad A, Casajoana A, Abdelbaki TN, Zheng MH. Erratum: Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021. EClinicalMedicine. 2024 Dec; 78:102958. PMID: 39640937; PMCID: PMC11617770.
    Citations:
  9. Stefanakis K, Mingrone G, George J, Mantzoros CS. Accurate non-invasive detection of MASH with fibrosis F2-F3 using a lightweight machine learning model with minimal clinical and metabolomic variables. Metabolism. 2025 Feb; 163:156082. PMID: 39566717.
    Citations:
    Fields: MetMetabolism
  10. Tsaknakis G, Boutakoglou E, Mavroudi I, Mantzoros CS, Cunha MV, Papadaki HA. Successful repurposing of empagliflozin to treat neutropenia in a severe congenital neutropenia patient with G6PC3 mutations. Metabolism. 2025 Jan; 162:156077. PMID: 39557394.
    Citations:
    Fields: MetMetabolism
  11. Zhou XD, Chen QF, Targher G, Byrne CD, Mantzoros CS, Zhang H, Lonardo A, Lip GYH, Porta G, Misra A, Robertson AG, Luo F, Alisi A, Yang W, El-Shabrawi M, Al Momani H, Somers VK, Katsouras CS, Méndez-Sánchez N, Lefere S, Szepietowski O, Sung KC, Hui Ng NB, Valenti L, Lee WS, Pik-Shan Kong A, Kizilkaya MC, Ocama P, Ali A, Viveiros O, Ryan JD, Toro-Huamanchumo CJ, Perera N, Ataya K, Yen Kok KY, Gracia-Sancho J, Sharara AI, Prasad A, Oviedo RJ, Ospanov O, Ruiz-Úcar E, Alswat K, Abbas SI, Abdelbaki TN, Wong YJ, Fouad Y, Shapiro MD, Bacopoulou F, Sookoian S, Kehar M, Chan WK, Treeprasertsuk S, Adams L, Turan S, Zuluaga M, Pirola CJ, Thaher O, Molina GA, Jumaev NA, Al-Busafi SA, Opio CK, Lim-Loo MC, Adithya Lesmana CR, Kamani L, Zheng MH. Global burden of disease attributable to metabolic risk factors in adolescents and young adults aged 15-39, 1990-2021. Clin Nutr. 2024 Dec; 43(12):391-404. PMID: 39579593.
    Citations:
    Fields: NutNutritional SciencesTranslation:Humans
  12. Skarmaliorakis I, Vasilopoulou A, Gutierrez de Piñeres V, Yannakoulia M, Anastasiou CA, Mantzoros CS. Regulation of proglucagon derived peptides by carbohydrate and protein ingestion in young healthy males-A randomized, double-blind, cross-over trial. Clin Nutr. 2025 Jan; 44:33-40. PMID: 39612864.
    Citations:
    Fields: NutNutritional Sciences
  13. Ajoolabady A, Pratico D, Lin L, Mantzoros CS, Bahijri S, Tuomilehto J, Ren J. Inflammation in atherosclerosis: pathophysiology and mechanisms. Cell Death Dis. 2024 Nov 11; 15(11):817. PMID: 39528464; PMCID: PMC11555284.
    Citations:
    Fields: CelCell BiologyIntInternal MedicineTranslation:HumansAnimalsCells
  14. Stefanakis K, Upadhyay J, Ramirez-Cisneros A, Patel N, Sahai A, Mantzoros CS. Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health. Metabolism. 2024 Dec; 161:156056. PMID: 39481533.
    Citations:
    Fields: MetMetabolismTranslation:HumansAnimals
  15. Stefanakis K, Kokkorakis M, Mantzoros CS. The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation. Metabolism. 2024 Dec; 161:156057. PMID: 39481534.
    Citations:
    Fields: MetMetabolismTranslation:Humans
  16. Perakakis N, Mantzoros CS. Evidence from clinical studies of leptin: current and future clinical applications in humans. Metabolism. 2024 Dec; 161:156053. PMID: 39490439.
    Citations:
    Fields: MetMetabolismTranslation:HumansAnimals
  17. Seo YG, Polyzos SA, Park KH, Mantzoros CS. Noninvasive Hepatic Steatosis and Fibrosis Indices Differentially Predict Mortality in the Adult Korean Population. Clin Gastroenterol Hepatol. 2024 Oct 26. PMID: 39490947.
    Citations:
    Fields: GasGastroenterology
  18. Boutari C, Rizos CV, Liamis G, Skoumas I, Rallidis L, Garoufi A, Kolovou G, Sfikas G, Tziomalos K, Skalidis E, Kotsis V, Doumas M, Stamatelopoulos K, Lambadiari V, Anagnostis P, Boufidou A, Giannakopoulou V, Anastasiou G, Petkou E, Vlachopoulos C, Dima I, Fakas G, Papathanasiou KA, Attilakos A, Kolovou V, Koumaras C, Agapakis D, Zacharis E, Antza C, Milionis H, Liberopoulos E, Mantzoros CS. The effect of lipid-lowering treatment on indices of MASLD in familial hypercholesterolemia patients. Clin Nutr. 2024 Dec; 43(12):84-91. PMID: 39437569.
    Citations:
    Fields: NutNutritional SciencesTranslation:Humans
  19. Kokkorakis M, Folkertsma P, Forte JC, Wolffenbuttel BHR, van Dam S, Mantzoros CS. GDF-15 improves the predictive capacity of steatotic liver disease non-invasive tests for incident morbidity and mortality risk for cardio-renal-metabolic diseases and malignancies. Metabolism. 2025 Feb; 163:156047. PMID: 39396641.
    Citations:
    Fields: MetMetabolism
  20. Kouvari M, Valenzuela-Vallejo L, Guatibonza-Garcia V, Verrastro O, Axarloglou E, Mylonakis SC, George J, Papatheodoridis G, Mingrone G, Mantzoros CS. Apolipoprotein C-III in association with metabolic-dysfunction associated steatotic liver disease: A large, multicenter study. Clin Nutr. 2024 Dec; 43(12):101-108. PMID: 39442390.
    Citations:
    Fields: NutNutritional SciencesTranslation:Humans
  21. Anastasiou G, Stefanakis K, Hill MA, Mantzoros CS. Expanding diagnostic and therapeutic horizons for MASH: Comparison of the latest and conventional therapeutic approaches. Metabolism. 2024 Dec; 161:156044. PMID: 39362519.
    Citations:
    Fields: MetMetabolism
  22. Agraz M, Deng Y, Karniadakis GE, Mantzoros CS. Enhancing severe hypoglycemia prediction in type 2 diabetes mellitus through multi-view co-training machine learning model for imbalanced dataset. Sci Rep. 2024 09 30; 14(1):22741. PMID: 39349500; PMCID: PMC11444036.
    Citations:
    Fields: SciScienceTranslation:Humans
  23. Zhou XD, Chen QF, Yang W, Zuluaga M, Targher G, Byrne CD, Valenti L, Luo F, Katsouras CS, Thaher O, Misra A, Ataya K, Oviedo RJ, Pik-Shan Kong A, Alswat K, Lonardo A, Wong YJ, Abu-Abeid A, Al Momani H, Ali A, Molina GA, Szepietowski O, Jumaev NA, Kizilkaya MC, Viveiros O, Toro-Huamanchumo CJ, Yen Kok KY, Ospanov O, Abbas SI, Robertson AG, Fouad Y, Mantzoros CS, Zhang H, Méndez-Sánchez N, Sookoian S, Chan WK, Treeprasertsuk S, Adams L, Ocama P, Ryan JD, Perera N, Sharara AI, Al-Busafi SA, Opio CK, Garcia M, Lim-Loo MC, Ruiz-Úcar E, Prasad A, Casajoana A, Abdelbaki TN, Zheng MH. Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021. EClinicalMedicine. 2024 Oct; 76:102848. PMID: 39386160; PMCID: PMC11462227.
    Citations: 2
  24. Angelidi AM, Stefanakis K, Chou SH, Valenzuela-Vallejo L, Dipla K, Boutari C, Ntoskas K, Tokmakidis P, Kokkinos A, Goulis DG, Papadaki HA, Mantzoros CS. Relative Energy Deficiency in Sport (REDs): Endocrine Manifestations, Pathophysiology and Treatments. Endocr Rev. 2024 Sep 12; 45(5):676-708. PMID: 38488566.
    Citations: 4
    Fields: EndEndocrinologyTranslation:Humans
  25. Zeng XF, Varady KA, Wang XD, Targher G, Byrne CD, Tayyem R, Latella G, Bergheim I, Valenzuela R, George J, Newberry C, Zheng JS, George ES, Spearman CW, Kontogianni MD, Ristic-Medic D, Peres WAF, Depboylu GY, Yang W, Chen X, Rosqvist F, Mantzoros CS, Valenti L, Yki-Järvinen H, Mosca A, Sookoian S, Misra A, Yilmaz Y, Kim W, Fouad Y, Sebastiani G, Wong VW, Åberg F, Wong YJ, Zhang P, Bermúdez-Silva FJ, Ni Y, Lupsor-Platon M, Chan WK, Méndez-Sánchez N, de Knegt RJ, Alam S, Treeprasertsuk S, Wang L, Du M, Zhang T, Yu ML, Zhang H, Qi X, Liu X, Pinyopornpanish K, Fan YC, Niu K, Jimenez-Chillaron JC, Zheng MH. The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus. Metabolism. 2024 Dec; 161:156028. PMID: 39270816.
    Citations: 2
    Fields: MetMetabolismTranslation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.