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profileChristos Mantzoros, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Endocrine, FLD-876
330 Brookline Ave
Boston MA 02215
Phone617/667-8630
Fax617/667-8634
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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
I01CX000422     (MANTZOROS, CHRISTOS S)Apr 1, 2011 - Jun 30, 2015
VA
Leptin Signaling in Humans
Role: Principal Investigator

K24DK081913     (MANTZOROS, CHRISTOS S)Sep 15, 2008 - Jun 30, 2021
NIH/NIDDK
Adipokine physiology
Role: Principal Investigator

R01DK079929     (MANTZOROS, CHRISTOS S)Jul 15, 2008 - Jun 30, 2014
NIH/NIDDK
The Role of Leptin in the Maintenance of a Reduced Body Weight
Role: Principal Investigator

R34HD048526     (MANTZOROS, CHRISTOS S)Aug 1, 2005 - Jul 31, 2006
NIH/NICHD
Clinical trial of leptin for hypothalamic amenorrhea
Role: Principal Investigator

R01DK058785     (MANTZOROS, CHRISTOS S)Dec 1, 2000 - Nov 30, 2012
NIH/NIDDK
Role of leptin in the neuroendocrine response to fasting
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Katsiki N, Mantzoros C, Mikhailidis DP. Adiponectin, lipids and atherosclerosis. Curr Opin Lipidol. 2017 Aug; 28(4):347-354. PMID: 28463859.
    View in: PubMed
  2. Farr OM, Tuccinardi D, Upadhyay J, Oussaada SM, Mantzoros CS. Walnut consumption increases activation of the insula to highly desirable food cues: A randomized, double-blind, placebo-controlled, cross-over fMRI study. Diabetes Obes Metab. 2017 Jul 17. PMID: 28715141.
    View in: PubMed
  3. Polyzos SA, Mantzoros CS. Lipodystrophy: Time for a global registry and randomized clinical trials to assess efficacy, safety and cost-effectiveness of established and novel medications. Metabolism. 2017 Jul; 72:A4-A10. PMID: 28641789.
    View in: PubMed
  4. Farr OM, Rifas-Shiman SL, Oken E, Taveras EM, Mantzoros CS. Current child, but not maternal, snoring is bi-directionally related to adiposity and cardiometabolic risk markers: A cross-sectional and a prospective cohort analysis. Metabolism. 2017 Jun 29. PMID: 28774733.
    View in: PubMed
  5. Joung KE, Cataltepe SU, Michael Z, Christou H, Mantzoros CS. Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates. J Clin Endocrinol Metab. 2017 May 01; 102(5):1606-1613. PMID: 28324040.
    View in: PubMed
  6. Polyzos SA, Kountouras J, Mantzoros CS, Polymerou V, Katsinelos P. Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and fibrosis, and adipokine levels in non-alcoholic fatty liver disease: a randomized controlled trial. Diabetes Obes Metab. 2017 Apr 28. PMID: 28452101.
    View in: PubMed
  7. Katsiki N, Athyros VG, Mikhailidis DP, Mantzoros C. Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors: Shaping the future after the further cardiovascular outcomes research with PCSK9 inhibition in subjects with elevated risk (FOURIER) trial. Metabolism. 2017 Sep; 74:43-46. PMID: 28477848.
    View in: PubMed
  8. Fleisch AF, Rifas-Shiman SL, Rokoff LB, Hivert MF, Mantzoros CS, Oken E. Associations of maternal prenatal smoking with umbilical cord blood hormones: the Project Viva cohort. Metabolism. 2017 Jul; 72:18-26. PMID: 28641780.
    View in: PubMed
  9. Athyros VG, Alexandrides TK, Bilianou H, Cholongitas E, Doumas M, Ganotakis ES, Goudevenos J, Elisaf MS, Germanidis G, Giouleme O, Karagiannis A, Karvounis C, Katsiki N, Kotsis V, Kountouras J, Liberopoulos E, Pitsavos C, Polyzos S, Rallidis LS, Richter D, Tsapas AG, Tselepis AD, Tsioufis K, Tziomalos K, Tzotzas T, Vasiliadis TG, Vlachopoulos C, Mikhailidis DP, Mantzoros C. The use of statins alone, or in combination with pioglitazone and other drugs, for the treatment of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and related cardiovascular risk. An Expert Panel Statement. Metabolism. 2017 Jun; 71:17-32. PMID: 28521870.
    View in: PubMed
  10. Farr OM, Mantzoros CS. Treating prediabetes in the obese: are GLP-1 analogues the answer? Lancet. 2017 Apr 08; 389(10077):1371-1372. PMID: 28237265.
    View in: PubMed
  11. Perakakis N, Triantafyllou GA, Fernández-Real JM, Huh JY, Park KH, Seufert J, Mantzoros CS. Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol. 2017 Jun; 13(6):324-337. PMID: 28211512.
    View in: PubMed
  12. Sadim M, Xu Y, Selig K, Paulus J, Uthe R, Agarwl S, Dubin I, Oikonomopoulou P, Zaichenko L, McCandlish SA, Van Horn L, Mantzoros C, Ankerst DP, Kaklamani VG. A prospective evaluation of clinical and genetic predictors of weight changes in breast cancer survivors. Cancer. 2017 Jul 01; 123(13):2413-2421. PMID: 28195643.
    View in: PubMed
  13. Chatzi L, Rifas-Shiman SL, Georgiou V, Joung KE, Koinaki S, Chalkiadaki G, Margioris A, Sarri K, Vassilaki M, Vafeiadi M, Kogevinas M, Mantzoros C, Gillman MW, Oken E. Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood. Pediatr Obes. 2017 Aug; 12 Suppl 1:47-56. PMID: 28160450.
    View in: PubMed
  14. Farr OM, Mantzoros CS. Sleep apnea in relation to metabolism: An urgent need to study underlying mechanisms and to develop novel treatments for this unmet clinical need. Metabolism. 2017 Apr; 69:207-210. PMID: 28190524.
    View in: PubMed
  15. Rifas-Shiman SL, Fleisch A, Hivert MF, Mantzoros C, Gillman MW, Oken E. First and second trimester gestational weight gains are most strongly associated with cord blood levels of hormones at delivery important for glycemic control and somatic growth. Metabolism. 2017 Apr; 69:112-119. PMID: 28285640.
    View in: PubMed
  16. Farr OM, Mantzoros CS. Treatment options to prevent diabetes in subjects with prediabetes: Efficacy, cost effectiveness and future outlook. Metabolism. 2017 May; 70:192-195. PMID: 28095990.
    View in: PubMed
  17. Farr OM, Mantzoros CS. Obese individuals with more components of the metabolic syndrome and/or prediabetes demonstrate decreased activation of reward-related brain centers in response to food cues in both the fed and fasting states: a preliminary fMRI study. Int J Obes (Lond). 2017 Mar; 41(3):471-474. PMID: 28017966.
    View in: PubMed
  18. Choe EY, Wang HJ, Kwon O, Kim KJ, Kim BS, Lee BW, Ahn CW, Cha BS, Lee HC, Kang ES, Mantzoros CS. Corrigendum to "Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes" [Metab. Clin. Exp. 62 (2013) 677-685]. Metabolism. 2017 Feb; 67:115. PMID: 27912896.
    View in: PubMed
  19. Perakakis N, Farr OM, Tuccinardi D, Upadhyay J, Mantzoros CS. Research advances in metabolism 2016. Metabolism. 2017 Feb; 67:41-53. PMID: 28081777.
    View in: PubMed
  20. Polyzos SA, Kountouras J, Mantzoros CS. Adipose tissue, obesity and non-alcoholic fatty liver disease. Minerva Endocrinol. 2017 Jun; 42(2):92-108. PMID: 27711029.
    View in: PubMed
  21. Liu X, Perakakis N, Gong H, Chamberland JP, Brinkoetter MT, Hamnvik OR, Mantzoros CS. Adiponectin administration prevents weight gain and glycemic profile changes in diet-induced obese immune deficient Rag1-/- mice lacking mature lymphocytes. Metabolism. 2016 Dec; 65(12):1720-1730. PMID: 27832860.
    View in: PubMed
  22. Triantafyllou GA, Paschou SA, Mantzoros CS. Leptin and Hormones: Energy Homeostasis. Endocrinol Metab Clin North Am. 2016 Sep; 45(3):633-45. PMID: 27519135.
    View in: PubMed
  23. Katsiki N, Mantzoros CS. Statins in relation to adiponectin: A significant association with clinical implications. Atherosclerosis. 2016 Oct; 253:270-272. PMID: 27567030.
    View in: PubMed
  24. Polyzos SA, Bugianesi E, Kountouras J, Mantzoros CS. Nonalcoholic fatty liver disease: Updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-? agonists. Metabolism. 2017 Jan; 66:64-68. PMID: 27594084.
    View in: PubMed
  25. Oken E, Morton-Eggleston E, Rifas-Shiman SL, Switkowski KM, Hivert MF, Fleisch AF, Mantzoros C, Gillman MW. Sex-Specific Associations of Maternal Gestational Glycemia with Hormones in Umbilical Cord Blood at Delivery. Am J Perinatol. 2016 Nov; 33(13):1273-1281. PMID: 27490771.
    View in: PubMed
  26. Dagon Y, Mantzoros CS, Kim YB. AMPK?Sirt1: From a signaling network to a combination drug. Metabolism. 2016 Nov; 65(11):1692-1694. PMID: 27558832.
    View in: PubMed
  27. Panagiotou G, Pazaitou-Panayiotou K, Paschou SA, Komninou D, Kalogeris N, Vryonidou A, Mantzoros CS. Changes in Thyroid Hormone Levels Within the Normal and/or Subclinical Hyper- or Hypothyroid Range Do Not Affect Circulating Irisin Levels in Humans. Thyroid. 2016 Aug; 26(8):1039-45. PMID: 27267080.
    View in: PubMed
  28. Gavrieli A, Mantzoros CS. Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss. Endocrinol Metab (Seoul). 2016 Sep; 31(3):361-372. PMID: 27469065.
    View in: PubMed
  29. Polyzos SA, Kountouras J, Anastasilakis AD, Triantafyllou G?, Mantzoros CS. Activin A and follistatin in patients with nonalcoholic fatty liver disease. Metabolism. 2016 Oct; 65(10):1550-8. PMID: 27621190; PMCID: PMC5022788 [Available on 10/01/17].
  30. Sousa-Lima I, Park SY, Chung M, Jung HJ, Kang MC, Gaspar JM, Seo JA, Macedo MP, Park KS, Mantzoros C, Lee SH, Kim YB. Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. Metabolism. 2016 Oct; 65(10):1508-21. PMID: 27621186.
    View in: PubMed
  31. Anastasilakis AD, Polyzos SA, Skouvaklidou EC, Kynigopoulos G, Saridakis ZG, Apostolou A, Triantafyllou GA, Karagiozoglou-Lampoudi T, Mantzoros CS. Circulating follistatin displays a day-night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans. Metabolism. 2016 Oct; 65(10):1459-65. PMID: 27621181; PMCID: PMC5022793 [Available on 10/01/17].
  32. Farr OM, Upadhyay J, Gavrieli A, Camp M, Spyrou N, Kaye H, Mathew H, Vamvini M, Koniaris A, Kilim H, Srnka A, Migdal A, Mantzoros CS. Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Diabetes. 2016 Oct; 65(10):2943-53. PMID: 27385157; PMCID: PMC5033259 [Available on 10/01/17].
  33. Neocleous V, Shammas C, Phelan MM, Fanis P, Pantelidou M, Skordis N, Mantzoros C, Phylactou LA, Toumba M. A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity. Hormones (Athens). 2016 Jul; 15(3):445-452. PMID: 27394708.
    View in: PubMed
  34. Gasbarrino K, Mantzoros C, Gorgui J, Veinot JP, Lai C, Daskalopoulou SS. Circulating Chemerin Is Associated With Carotid Plaque Instability, Whereas Resistin Is Related to Cerebrovascular Symptomatology. Arterioscler Thromb Vasc Biol. 2016 Aug; 36(8):1670-8. PMID: 27312219.
    View in: PubMed
  35. Perakakis N, Mantzoros CS. Immune therapy in type 1 diabetes mellitus - Attempts to untie the Gordian knot? Metabolism. 2016 Sep; 65(9):1278-85. PMID: 27506735.
    View in: PubMed
  36. Polyzos SA, Mantzoros CS. Adiponectin as a target for the treatment of nonalcoholic steatohepatitis with thiazolidinediones: A systematic review. Metabolism. 2016 Sep; 65(9):1297-306. PMID: 27506737.
    View in: PubMed
  37. Gavrieli A, Panagiotou G, Mantzoros CS. Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans. Int J Obes (Lond). 2016 Sep; 40(9):1461-3. PMID: 27200503.
    View in: PubMed
  38. Katsiki N, Mikhailidis DP, Mantzoros CS. Non-alcoholic fatty liver disease and dyslipidemia: An update. Metabolism. 2016 Aug; 65(8):1109-23. PMID: 27237577.
    View in: PubMed
  39. Farr OM, Tsoukas MA, Triantafyllou G, Dincer F, Filippaios A, Ko BJ, Mantzoros CS. Short-term administration of the GLP-1 analog liraglutide decreases circulating leptin and increases GIP levels and these changes are associated with alterations in CNS responses to food cues: A randomized, placebo-controlled, crossover study. Metabolism. 2016 Jul; 65(7):945-53. PMID: 27282865; PMCID: PMC4902873 [Available on 07/01/17].
  40. Tsompanidis A, Vafiadaki E, Blüher S, Kalozoumi G, Sanoudou D, Mantzoros CS. Ciliary neurotrophic factor upregulates follistatin and Pak1, causes overexpression of muscle differentiation related genes and downregulation of established atrophy mediators in skeletal muscle. Metabolism. 2016 Jun; 65(6):915-25. PMID: 27173470.
    View in: PubMed
  41. Vamvini MT, Hamnvik OP, Sahin-Efe A, Gavrieli A, Dincer F, Farr OM, Mantzoros CS. Differential Effects of Oral and Intravenous Lipid Administration on Key Molecules Related to Energy Homeostasis. J Clin Endocrinol Metab. 2016 May; 101(5):1989-97. PMID: 26964729; PMCID: PMC4870849 [Available on 05/01/17].
  42. Karakosta P, Roumeliotaki T, Chalkiadaki G, Sarri K, Vassilaki M, Venihaki M, Malliaraki N, Kampa M, Castanas E, Kogevinas M, Mantzoros C, Chatzi L. Cord blood leptin levels in relation to child growth trajectories. Metabolism. 2016 Jun; 65(6):874-82. PMID: 27173466.
    View in: PubMed
  43. Farr OM, Li CS, Mantzoros CS. Central nervous system regulation of eating: Insights from human brain imaging. Metabolism. 2016 May; 65(5):699-713. PMID: 27085777; PMCID: PMC4834455 [Available on 05/01/17].
  44. Fleisch AF, Luttmann-Gibson H, Perng W, Rifas-Shiman SL, Coull BA, Kloog I, Koutrakis P, Schwartz JD, Zanobetti A, Mantzoros CS, Gillman MW, Gold DR, Oken E. Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood. Pediatr Obes. 2017 Feb; 12(1):48-57. PMID: 26843357.
    View in: PubMed
  45. Farr OM, Sofopoulos M, Tsoukas MA, Dincer F, Thakkar B, Sahin-Efe A, Filippaios A, Bowers J, Srnka A, Gavrieli A, Ko BJ, Liakou C, Kanyuch N, Tseleni-Balafouta S, Mantzoros CS. GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial. Diabetologia. 2016 05; 59(5):954-65. PMID: 26831302; PMCID: PMC4826792 [Available on 05/01/17].
  46. Chakhtoura MT, Nakhoul N, Akl EA, Mantzoros CS, El Hajj Fuleihan GA. Guidelines on vitamin D replacement in bariatric surgery: Identification and systematic appraisal. Metabolism. 2016 Apr; 65(4):586-97. PMID: 26833101; PMCID: PMC4792722 [Available on 04/01/17].
  47. Polyzos SA, Mantzoros CS. Nonalcoholic fatty future disease. Metabolism. 2016 Aug; 65(8):1007-16. PMID: 26805015.
    View in: PubMed
  48. Chakhtoura MT, Nakhoul NN, Shawwa K, Mantzoros C, El Hajj Fuleihan GA. Hypovitaminosis D in bariatric surgery: A systematic review of observational studies. Metabolism. 2016 Apr; 65(4):574-85. PMID: 26805016; PMCID: PMC4792683 [Available on 04/01/17].
  49. Ahasic AM, Tejera P, Wei Y, Su L, Mantzoros CS, Bajwa EK, Thompson BT, Christiani DC. Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 in Critical Illness. Crit Care Med. 2015 Dec; 43(12):2651-9. PMID: 26427594; PMCID: PMC4651824 [Available on 12/01/16].
  50. Crowell JA, Davis CR, Joung KE, Usher N, McCormick SP, Dearing E, Mantzoros CS. Metabolic pathways link childhood adversity to elevated blood pressure in midlife adults. Obes Res Clin Pract. 2016 Sep - Oct; 10(5):580-588. PMID: 26598448.
    View in: PubMed
  51. Polyzos SA, Kountouras J, Mantzoros CS. Adipokines in nonalcoholic fatty liver disease. Metabolism. 2016 Aug; 65(8):1062-79. PMID: 26725002.
    View in: PubMed
  52. Inamura K, Song M, Jung S, Nishihara R, Yamauchi M, Lochhead P, Qian ZR, Kim SA, Mima K, Sukawa Y, Masuda A, Imamura Y, Zhang X, Pollak MN, Mantzoros CS, Harris CC, Giovannucci E, Fuchs CS, Cho E, Chan AT, Wu K, Ogino S. Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According to KRAS Mutation Status. J Natl Cancer Inst. 2016 Apr; 108(4). PMID: 26598515; PMCID: PMC4668768 [Available on 04/01/17].
  53. Mathew H, Farr OM, Mantzoros CS. Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients. Metabolism. 2016 Jan; 65(1):73-80. PMID: 26683798; PMCID: PMC4750380 [Available on 01/01/17].
  54. Paschou SA, Spyrou N, Mantzoros CS. Research advances in metabolism 2015. Metabolism. 2016 Mar; 65(3):27-37. PMID: 26892513.
    View in: PubMed
  55. Pazaitou-Panayiotou K, Panagiotou G, Polyzos SA, Mantzoros CS. SERUM ADIPONECTIN AND INSULIN-LIKE GROWTH FACTOR 1 IN PREDOMINANTLY FEMALE PATIENTS WITH THYROID CANCER: ASSOCIATION WITH THE HISTOLOGIC CHARACTERISTICS OF THE TUMOR. Endocr Pract. 2016 Jan; 22(1):68-75. PMID: 26484409.
    View in: PubMed
  56. Farr OM, Gavrieli A, Mantzoros CS. Leptin applications in 2015: what have we learned about leptin and obesity? Curr Opin Endocrinol Diabetes Obes. 2015 Oct; 22(5):353-9. PMID: 26313897; PMCID: PMC4610373 [Available on 10/01/16].
  57. Polyzos SA, Aronis KN, Kountouras J, Raptis DD, Vasiloglou MF, Mantzoros CS. Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis. Diabetologia. 2016 Jan; 59(1):30-43. PMID: 26407715.
    View in: PubMed
  58. Gavrieli A, Farr OM, Davis CR, Crowell JA, Mantzoros CS. Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours of resting or sleeping in a US middle-aged population: A cross-sectional and prospective study. Metabolism. 2015 Nov; 64(11):1597-610. PMID: 26404481; PMCID: PMC4609606 [Available on 11/01/16].
  59. Polyzos SA, Mathew H, Mantzoros CS. Irisin: A true, circulating hormone. Metabolism. 2015 Dec; 64(12):1611-8. PMID: 26422316.
    View in: PubMed
  60. Dalamaga M, Polyzos SA, Karmaniolas K, Chamberland J, Lekka A, Triantafilli M, Migdalis I, Papadavid E, Mantzoros CS. Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study. Leuk Lymphoma. 2016; 57(3):577-84. PMID: 26317877.
    View in: PubMed
  61. Joung KE, Park KH, Filippaios A, Dincer F, Christou H, Mantzoros CS. Cord blood irisin levels are positively correlated with birth weight in newborn infants. Metabolism. 2015 Nov; 64(11):1507-14. PMID: 26303870.
    View in: PubMed
  62. Alonso A, Bahnson JL, Gaussoin SA, Bertoni AG, Johnson KC, Lewis CE, Vetter M, Mantzoros CS, Jeffery RW, Soliman EZ. Effect of an intensive lifestyle intervention on atrial fibrillation risk in individuals with type 2 diabetes: the Look AHEAD randomized trial. Am Heart J. 2015 Oct; 170(4):770-777.e5. PMID: 26386801; PMCID: PMC4576158 [Available on 10/01/16].
  63. Lee YH, Armstrong EJ, Kim G, Oh J, Kang SM, Lee BW, Ahn CW, Cha BS, Lee HC, Mantzoros CS, Kang ES. Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes. Am Heart J. 2015 Oct; 170(4):760-769.e2. PMID: 26386800.
    View in: PubMed
  64. Sternthal E, Underwood P, Mantzoros CS. Slip sliding away: the need for continued discussion of the use of insulin sliding scale in hospitalized patients. Metabolism. 2015 Sep; 64(9):935-6. PMID: 26159821.
    View in: PubMed
  65. Cooke AB, Toli E, Gomez YH, Mutter AF, Eisenberg MJ, Mantzoros CS, Daskalopoulou SS. From rest to stressed: endothelin-1 levels in young healthy smokers and non-smokers. Metabolism. 2015 Sep; 64(9):1103-11. PMID: 26141182.
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  66. Polyzos SA, Mantzoros CS. An update on the validity of irisin assays and the link between irisin and hepatic metabolism. Metabolism. 2015 Sep; 64(9):937-42. PMID: 26130607.
    View in: PubMed
  67. Liu X, Huh JY, Gong H, Chamberland JP, Brinkoetter MT, Hamnvik OP, Mantzoros CS. Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high-fat diet. Int J Obes (Lond). 2015 Oct; 39(10):1548-57. PMID: 25994806.
    View in: PubMed
  68. Sahin-Efe A, Polyzos SA, Dincer F, Zaichenko L, McGovern R, Schneider B, Mantzoros CS. Intracellular leptin signaling following effective weight loss. Metabolism. 2015 Aug; 64(8):888-95. PMID: 25998856.
    View in: PubMed
  69. Michalakis K, Venihaki M, Mantzoros C, Vazaiou A, Ilias I, Gryparis A, Margioris AN. In prostate cancer, low adiponectin levels are not associated with insulin resistance. Eur J Clin Invest. 2015 Jun; 45(6):572-8. PMID: 25833038.
    View in: PubMed
  70. Huh JY, Mantzoros CS. Irisin physiology, oxidative stress, and thyroid dysfunction: What next? Metabolism. 2015 Jul; 64(7):765-7. PMID: 25916681.
    View in: PubMed
  71. Ko BJ, Park KH, Shin S, Zaichenko L, Davis CR, Crowell JA, Joung H, Mantzoros CS. Diet quality and diet patterns in relation to circulating cardiometabolic biomarkers. Clin Nutr. 2016 Apr; 35(2):484-90. PMID: 25912185; PMCID: PMC4596724 [Available on 04/01/17].
  72. Tsoukas MA, Ko BJ, Witte TR, Dincer F, Hardman WE, Mantzoros CS. Dietary walnut suppression of colorectal cancer in mice: Mediation by miRNA patterns and fatty acid incorporation. J Nutr Biochem. 2015 Jul; 26(7):776-83. PMID: 25882694.
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  73. Dagon Y, Mantzoros C, Kim YB. Exercising insulin sensitivity: AMPK turns on autophagy! Metabolism. 2015 Jun; 64(6):655-7. PMID: 25819737; PMCID: PMC4709017.
  74. Lee S, Ko BJ, Gong Y, Han K, Lee A, Han BD, Yoon YJ, Park S, Kim JH, Mantzoros CS. Self-reported eating speed in relation to non-alcoholic fatty liver disease in adults. Eur J Nutr. 2016 Feb; 55(1):327-33. PMID: 25648740.
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  75. Farr OM, Ko BJ, Joung KE, Zaichenko L, Usher N, Tsoukas M, Thakkar B, Davis CR, Crowell JA, Mantzoros CS. Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk. Nutr Metab Cardiovasc Dis. 2015 May; 25(5):479-88. PMID: 25770759; PMCID: PMC4404181.
  76. Foo JP, Aronis KN, Chamberland JP, Mantzoros CS. Lack of Day/Night variation in fibroblast growth factor 21 levels in young healthy men. Int J Obes (Lond). 2015 Jun; 39(6):945-8. PMID: 25540981.
    View in: PubMed
  77. Farr OM, Camp M, Mantzoros CS. New research developments and insights from Metabolism. Metabolism. 2015 Mar; 64(3):354-67. PMID: 25549908; PMCID: PMC4459594.
  78. Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab. 2015 Mar; 100(3):E453-7. PMID: 25514098.
    View in: PubMed
  79. Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H. Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes. Gastroenterology. 2015 Mar; 148(3):626-638.e17. PMID: 25497209.
    View in: PubMed
  80. Batirel S, Bozaykut P, Mutlu Altundag E, Kartal Ozer N, Mantzoros CS. The effect of Irisin on antioxidant system in liver. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S16. PMID: 26461295.
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  81. Farr OM, Fiorenza C, Papageorgiou P, Brinkoetter M, Ziemke F, Koo BB, Rojas R, Mantzoros CS. Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin-sensitive subjects without altering brain structure. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2529-38. PMID: 25279500; PMCID: PMC4255115.
  82. Polyzos SA, Kountouras J, Anastasilakis AD, Margouta A, Mantzoros CS. Association between circulating irisin and homocysteine in patients with nonalcoholic fatty liver disease. Endocrine. 2015 Jun; 49(2):560-2. PMID: 25381603.
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  83. Katsiki N, Rizzo M, Mikhailidis DP, Mantzoros CS. New-onset diabetes and statins: throw the bath water out, but, please, keep the baby! Metabolism. 2015 Apr; 64(4):471-5. PMID: 25484289.
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  84. Ahasic AM, Zhai R, Su L, Zhao Y, Aronis KN, Thompson BT, Mantzoros CS, Christiani DC. IGF1 and IGFBP3 in acute respiratory distress syndrome. Eur J Endocrinol. 2014 Nov; 171(5):X4. PMID: 25319218.
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  85. Friedman JM, Mantzoros CS. 20 years of leptin: from the discovery of the leptin gene to leptin in our therapeutic armamentarium. Metabolism. 2015 Jan; 64(1):1-4. PMID: 25497341.
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  86. Dalamaga M, Polyzos SA, Karmaniolas K, Chamberland J, Lekka A, Migdalis I, Papadavid E, Dionyssiou-Asteriou A, Mantzoros CS. Circulating fetuin-A in patients with pancreatic cancer: a hospital-based case-control study. Biomarkers. 2014 Dec; 19(8):660-6. PMID: 25347061.
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  87. Upadhyay J, Farr OM, Mantzoros CS. The role of leptin in regulating bone metabolism. Metabolism. 2015 Jan; 64(1):105-13. PMID: 25497343; PMCID: PMC4532332.
  88. Polyzos SA, Mantzoros CS. Leptin in health and disease: facts and expectations at its twentieth anniversary. Metabolism. 2015 Jan; 64(1):5-12. PMID: 25467841.
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  89. Blüher M, Mantzoros CS. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism. 2015 Jan; 64(1):131-45. PMID: 25497344.
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  90. Polyzos SA, Kountouras J, Mantzoros CS. Leptin in nonalcoholic fatty liver disease: a narrative review. Metabolism. 2015 Jan; 64(1):60-78. PMID: 25456097.
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  91. Procaccini C, Pucino V, Mantzoros CS, Matarese G. Leptin in autoimmune diseases. Metabolism. 2015 Jan; 64(1):92-104. PMID: 25467840.
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  92. Goundan PN, Underwood P, Mantzoros CS. Incretin therapy and beta cell function. Metabolism. 2015 Feb; 64(2):157-9. PMID: 25456457.
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  93. Davis CR, Usher N, Dearing E, Barkai AR, Crowell-Doom C, Neupert SD, Mantzoros CS, Crowell JA. Attachment and the metabolic syndrome in midlife: the role of interview-based discourse patterns. Psychosom Med. 2014 Oct; 76(8):611-21. PMID: 25264975.
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  94. Moon HS, Huh JY, Dincer F, Schneider BE, Hasselgren PO, Mantzoros CS. Identification and saturable nature of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo, and in vitro administration. Diabetes. 2015 Mar; 64(3):828-39. PMID: 25249580; PMCID: PMC4338590.
  95. Stieg MR, Sievers C, Farr O, Stalla GK, Mantzoros CS. Leptin: A hormone linking activation of neuroendocrine axes with neuropathology. Psychoneuroendocrinology. 2015 Jan; 51:47-57. PMID: 25290346.
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  96. Perng W, Gillman MW, Mantzoros CS, Oken E. A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood. Ann Epidemiol. 2014 Nov; 24(11):793-800.e1. PMID: 25263237; PMCID: PMC4254266.
  97. Farr OM, Sloan DM, Keane TM, Mantzoros CS. Stress- and PTSD-associated obesity and metabolic dysfunction: a growing problem requiring further research and novel treatments. Metabolism. 2014 Dec; 63(12):1463-8. PMID: 25267015; PMCID: PMC4459590.
  98. Foo JP, Polyzos SA, Anastasilakis AD, Chou S, Mantzoros CS. The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and Wnt inhibitors in young women with hypothalamic amenorrhea. J Clin Endocrinol Metab. 2014 Nov; 99(11):E2252-8. PMID: 25148234.
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  99. Huh JY, Mougios V, Kabasakalis A, Fatouros I, Siopi A, Douroudos II, Filippaios A, Panagiotou G, Park KH, Mantzoros CS. Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. J Clin Endocrinol Metab. 2014 Nov; 99(11):E2154-61. PMID: 25119310.
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  100. Tsoukas MA, Farr OM, Mantzoros CS. Leptin in congenital and HIV-associated lipodystrophy. Metabolism. 2015 Jan; 64(1):47-59. PMID: 25267014.
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  101. Moon HS, Batirel S, Mantzoros CS. Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells. Metabolism. 2014 Nov; 63(11):1447-54. PMID: 25129649.
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  102. Chou SH, Mantzoros C. 20 years of leptin: role of leptin in human reproductive disorders. J Endocrinol. 2014 Oct; 223(1):T49-62. PMID: 25056118.
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  103. Farr OM, Tsoukas MA, Mantzoros CS. Leptin and the brain: influences on brain development, cognitive functioning and psychiatric disorders. Metabolism. 2015 Jan; 64(1):114-30. PMID: 25092133.
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  104. Hamnvik OR, Thakkar B, Chamberland J, Aronis K, Schneider B, Mantzoros CS. Omentin-1 levels are reduced by pharmacologic doses of leptin, but remain unaffected by energy deprivation and display no day-night variation. Int J Obes (Lond). 2015 Feb; 39(2):260-264. PMID: 24946907; PMCID: PMC4272682.
  105. Daskalopoulou SS, Cooke AB, Gomez YH, Mutter AF, Filippaios A, Mesfum ET, Mantzoros CS. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol. 2014 Sep; 171(3):343-52. PMID: 24920292.
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  106. Anastasilakis AD, Polyzos SA, Saridakis ZG, Kynigopoulos G, Skouvaklidou EC, Molyvas D, Vasiloglou MF, Apostolou A, Karagiozoglou-Lampoudi T, Siopi A, Mougios V, Chatzistavridis P, Panagiotou G, Filippaios A, Delaroudis S, Mantzoros CS. Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition. J Clin Endocrinol Metab. 2014 Sep; 99(9):3247-55. PMID: 24915120.
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  107. Panagiotou G, Mu L, Na B, Mukamal KJ, Mantzoros CS. Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk. Metabolism. 2014 Oct; 63(10):1265-71. PMID: 25060690; PMCID: PMC4175146.
  108. Aronis KN, Tsoukas MA, Mantzoros CS. Potential cardioprotective action of GLP-1: from bench to bedside. Metabolism. 2014 Aug; 63(8):979-88. PMID: 24956977.
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  109. Choi HY, Kim S, Park JW, Lee NS, Hwang SY, Huh JY, Hong HC, Yoo HJ, Baik SH, Youn BS, Mantzoros CS, Choi KM. Implication of circulating irisin levels with brown adipose tissue and sarcopenia in humans. J Clin Endocrinol Metab. 2014 Aug; 99(8):2778-85. PMID: 24780049.
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  110. Peter PR, Park KH, Huh JY, Wedick NM, Mantzoros CS. Circulating irisin levels are not affected by coffee intake: a randomized controlled trial. PLoS One. 2014; 9(4):e94463. PMID: 24728416; PMCID: PMC3984159.
  111. DePaoli AM, Higgins LS, Henry RR, Mantzoros C, Dunn FL. Can a selective PPAR? modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone? Diabetes Care. 2014 Jul; 37(7):1918-23. PMID: 24722496.
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  112. Huh JY, Mougios V, Skraparlis A, Kabasakalis A, Mantzoros CS. Irisin in response to acute and chronic whole-body vibration exercise in humans. Metabolism. 2014 Jul; 63(7):918-21. PMID: 24814685.
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  113. Blüher S, Panagiotou G, Petroff D, Markert J, Wagner A, Klemm T, Filippaios A, Keller A, Mantzoros CS. Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children. Obesity (Silver Spring). 2014 Jul; 22(7):1701-8. PMID: 24644099.
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  114. Joung KE, Park KH, Zaichenko L, Sahin-Efe A, Thakkar B, Brinkoetter M, Usher N, Warner D, Davis CR, Crowell JA, Mantzoros CS. Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults. J Clin Endocrinol Metab. 2014 Jun; 99(6):E1055-60. PMID: 24650014.
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  115. Ko BJ, Kim SM, Park KH, Park HS, Mantzoros CS. Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children. Int J Obes (Lond). 2014 Dec; 38(12):1497-502. PMID: 24638201.
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  116. Oken E, Baccarelli AA, Gold DR, Kleinman KP, Litonjua AA, De Meo D, Rich-Edwards JW, Rifas-Shiman SL, Sagiv S, Taveras EM, Weiss ST, Belfort MB, Burris HH, Camargo CA, Huh SY, Mantzoros C, Parker MG, Gillman MW. Cohort profile: project viva. Int J Epidemiol. 2015 Feb; 44(1):37-48. PMID: 24639442; PMCID: PMC4339753.
  117. Liu X, Hamnvik OP, Chamberland JP, Petrou M, Gong H, Christophi CA, Christiani DC, Kales SN, Mantzoros CS. Circulating alanine transaminase (ALT) and ?-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: the prospective Cyprus Metabolism Study. Metabolism. 2014 Jun; 63(6):773-82. PMID: 24726813; PMCID: PMC4104665.
  118. Huh JY, Dincer F, Mesfum E, Mantzoros CS. Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. Int J Obes (Lond). 2014 Dec; 38(12):1538-44. PMID: 24614098.
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  119. Anastasilakis AD, Polyzos SA, Makras P, Gkiomisi A, Bisbinas I, Katsarou A, Filippaios A, Mantzoros CS. Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months. Osteoporos Int. 2014 May; 25(5):1633-42. PMID: 24599275.
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  120. Aronis KN, Sahin-Efe A, Chamberland JP, Spiro A, Vokonas P, Mantzoros CS. Chemerin levels as predictor of acute coronary events: a case-control study nested within the veterans affairs normative aging study. Metabolism. 2014 Jun; 63(6):760-6. PMID: 24684821.
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  121. Brault M, Ray J, Gomez YH, Mantzoros CS, Daskalopoulou SS. Statin treatment and new-onset diabetes: a review of proposed mechanisms. Metabolism. 2014 Jun; 63(6):735-45. PMID: 24641882.
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  122. Hwang JJ, Thakkar B, Chamberland JP, Mantzoros CS. Circulating fetuin-A levels are not affected by short and long-term energy deprivation and/or by leptin administration. Metabolism. 2014 Jun; 63(6):754-9. PMID: 24703486.
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  123. Joung KE, Christou H, Park KH, Mantzoros CS. Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities. Obesity (Silver Spring). 2014 May; 22(5):1317-24. PMID: 24123979; PMCID: PMC4394598.
  124. Boström PA, Fernández-Real JM, Mantzoros C. Irisin in humans: recent advances and questions for future research. Metabolism. 2014 Feb; 63(2):178-80. PMID: 24342075.
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  125. Ko BJ, Park KH, Mantzoros CS. Diet patterns, adipokines, and metabolism: where are we and what is next? Metabolism. 2014 Feb; 63(2):168-77. PMID: 24360751.
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  126. Wu L, Piotrowski K, Rau T, Waldmann E, Broedl UC, Demmelmair H, Koletzko B, Stark RG, Nagel JM, Mantzoros CS, Parhofer KG. Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial. Metabolism. 2014 Mar; 63(3):382-91. PMID: 24360749.
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  127. Davis CR, Dearing E, Usher N, Trifiletti S, Zaichenko L, Ollen E, Brinkoetter MT, Crowell-Doom C, Joung K, Park KH, Mantzoros CS, Crowell JA. Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors. Metabolism. 2014 Feb; 63(2):199-206. PMID: 24211017.
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  128. Park KH, Zaichenko L, Peter P, Davis CR, Crowell JA, Mantzoros CS. Diet quality is associated with circulating C-reactive protein but not irisin levels in humans. Metabolism. 2014 Feb; 63(2):233-41. PMID: 24315778; PMCID: PMC4373656.
  129. Polyzos SA, Mantzoros CS. Necessity for timely noninvasive diagnosis of nonalcoholic fatty liver disease. Metabolism. 2014 Feb; 63(2):161-7. PMID: 24290839.
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  130. Moon HS, Mantzoros CS. Adiponectin and metformin additively attenuate IL1ß-induced malignant potential of colon cancer. Endocr Relat Cancer. 2013 Dec; 20(6):849-59. PMID: 24157941.
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  131. Moon HS, Mantzoros CS. Regulation of cell proliferation and malignant potential by irisin in endometrial, colon, thyroid and esophageal cancer cell lines. Metabolism. 2014 Feb; 63(2):188-93. PMID: 24268368.
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  132. Vamvini MT, Aronis KN, Panagiotou G, Huh JY, Chamberland JP, Brinkoetter MT, Petrou M, Christophi CA, Kales SN, Christiani DC, Mantzoros CS. Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans. Eur J Endocrinol. 2013 Dec; 169(6):829-34. PMID: 24062354; PMCID: PMC3857961.
  133. Polyzos SA, Kountouras J, Anastasilakis AD, Geladari EV, Mantzoros CS. Irisin in patients with nonalcoholic fatty liver disease. Metabolism. 2014 Feb; 63(2):207-17. PMID: 24140091.
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  134. Dalamaga M, Karmaniolas K, Chamberland J, Nikolaidou A, Lekka A, Dionyssiou-Asteriou A, Mantzoros CS. Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome. Metabolism. 2013 Dec; 62(12):1830-9. PMID: 24140093.
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  135. Tsoukas MA, Farr OM, Mantzoros CS. Advances in metabolism. Metabolism. 2013 Dec; 62(12):1700-13. PMID: 24112391.
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  136. Karas MG, Benkeser D, Arnold AM, Bartz TM, Djousse L, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Tracy RP, Mantzoros CS, Gottdiener JS, deFilippi CR, Kizer JR. Relations of plasma total and high-molecular-weight adiponectin to new-onset heart failure in adults =65 years of age (from the Cardiovascular Health study). Am J Cardiol. 2014 Jan 15; 113(2):328-34. PMID: 24169012; PMCID: PMC3968249.
  137. Park KH, Zaichenko L, Brinkoetter M, Thakkar B, Sahin-Efe A, Joung KE, Tsoukas MA, Geladari EV, Huh JY, Dincer F, Davis CR, Crowell JA, Mantzoros CS. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab. 2013 Dec; 98(12):4899-907. PMID: 24057291; PMCID: PMC3849667.
  138. Aronis KN, Mantzoros CS. Novel concepts in lipoprotein particle metabolism and regulation. Metabolism. 2014 Jan; 63(1):1-4. PMID: 24054823.
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  139. Chamberland JP, Berman RL, Aronis KN, Mantzoros CS. Chemerin is expressed mainly in pancreas and liver, is regulated by energy deprivation, and lacks day/night variation in humans. Eur J Endocrinol. 2013 Oct; 169(4):453-62. PMID: 23904282; PMCID: PMC3798003.
  140. Gouni-Berthold I, Berthold HK, Huh JY, Berman R, Spenrath N, Krone W, Mantzoros CS. Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo. PLoS One. 2013; 8(9):e72858. PMID: 24023786; PMCID: PMC3759413.
  141. Pazaitou-Panayiotou K, Polyzos SA, Mantzoros CS. Obesity and thyroid cancer: epidemiologic associations and underlying mechanisms. Obes Rev. 2013 Dec; 14(12):1006-22. PMID: 24034423.
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  142. Reddy SM, Sadim M, Li J, Yi N, Agarwal S, Mantzoros CS, Kaklamani VG. Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer. Br J Cancer. 2013 Aug 20; 109(4):872-81. PMID: 23922112; PMCID: PMC3749587.
  143. Foo JP, Aronis KN, Chamberland JP, Thakkar B, Hamnvik OP, Brinkoetter M, Zaichenko L, Mantzoros CS. Gender dimorphism and lack of day/night variation or effects of energy deprivation on undercarboxylated osteocalcin levels in humans. Obesity (Silver Spring). 2013 Dec; 21(12):E527-32. PMID: 23512912; PMCID: PMC4399799.
  144. Dalamaga M, Chou SH, Shields K, Papageorgiou P, Polyzos SA, Mantzoros CS. Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives. Cell Metab. 2013 Jul 02; 18(1):29-42. PMID: 23770129.
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  145. Aronis KN, Moreno M, Polyzos SA, Moreno-Navarrete JM, Ricart W, Delgado E, de la Hera J, Sahin-Efe A, Chamberland JP, Berman R, Spiro A, Vokonas P, Fernández-Real JM, Mantzoros CS. Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events. Int J Obes (Lond). 2015 Jan; 39(1):156-61. PMID: 24916788.
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  146. Boeke CE, Mantzoros CS, Hughes MD, L Rifas-Shiman S, Villamor E, Zera CA, Gillman MW. Differential associations of leptin with adiposity across early childhood. Obesity (Silver Spring). 2013 Jul; 21(7):1430-7. PMID: 23408391; PMCID: PMC3659179.
  147. Paruthi J, Gill N, Mantzoros CS. Adipokines in the HIV/HAART-associated lipodystrophy syndrome. Metabolism. 2013 Sep; 62(9):1199-205. PMID: 23706880.
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  148. Aronis KN, Chamberland JP, Mantzoros CS. GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways. Metabolism. 2013 Sep; 62(9):1279-86. PMID: 23684008; PMCID: PMC3755020.
  149. Gavrieli A, Karfopoulou E, Kardatou E, Spyreli E, Fragopoulou E, Mantzoros CS, Yannakoulia M. Effect of different amounts of coffee on dietary intake and appetite of normal-weight and overweight/obese individuals. Obesity (Silver Spring). 2013 Jun; 21(6):1127-32. PMID: 23671022.
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  150. Polyzos SA, Kountouras J, Shields K, Mantzoros CS. Irisin: a renaissance in metabolism? Metabolism. 2013 Aug; 62(8):1037-44. PMID: 23664085.
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  151. Moon HS, Dincer F, Mantzoros CS. Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines. Metabolism. 2013 Aug; 62(8):1131-6. PMID: 23664146; PMCID: PMC4370428.
  152. Kaklamani VG, Hoffmann TJ, Thornton TA, Hayes G, Chlebowski R, Van Horn L, Mantzoros C. Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative. Breast Cancer Res Treat. 2013 Jun; 139(2):461-8. PMID: 23624817; PMCID: PMC3773607.
  153. Discacciati A, Orsini N, Andersson SO, Andrén O, Johansson JE, Mantzoros CS, Wolk A. Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study. Ann Oncol. 2013 Jul; 24(7):1912-8. PMID: 23508823.
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  154. Gavrieli A, Fragopoulou E, Mantzoros CS, Yannakoulia M. Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial. Metabolism. 2013 Aug; 62(8):1099-106. PMID: 23498899.
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  155. Moon HS, Dalamaga M, Kim SY, Polyzos SA, Hamnvik OP, Magkos F, Paruthi J, Mantzoros CS. Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals. Endocr Rev. 2013 Jun; 34(3):377-412. PMID: 23475416; PMCID: PMC3660716.
  156. Huffman DM, Augenlicht LH, Zhang X, Lofrese JJ, Atzmon G, Chamberland JP, Mantzoros CS. Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice. Cancer Prev Res (Phila). 2013 Mar; 6(3):177-87. PMID: 23466815; PMCID: PMC3595118.
  157. Thakkar B, Aronis KN, Vamvini MT, Shields K, Mantzoros CS. Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies. Metabolism. 2013 Jul; 62(7):922-34. PMID: 23419783.
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  158. Matarese G, La Rocca C, Moon HS, Huh JY, Brinkoetter MT, Chou S, Perna F, Greco D, Kilim HP, Gao C, Arampatzi K, Wang Z, Mantzoros CS. Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):E818-27. PMID: 23382191; PMCID: PMC3587204.
  159. Foo JP, Mantzoros C. Early growth and development of later life metabolic disorders. Nestle Nutr Inst Workshop Ser. 2013; 71:75-84. PMID: 23502141.
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  160. Choe EY, Wang HJ, Kwon O, Kim KJ, Kim BS, Lee BW, Ahn CW, Cha BS, Lee HC, Kang ES, Mantzoros CS. Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes. Metabolism. 2013 May; 62(5):677-85. PMID: 23260797.
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  161. Moon HS, Dincer F, Mantzoros CS. Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice. Diabetologia. 2013 Mar; 56(3):627-34. PMID: 23224631.
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  162. Foo JP, Aronis KN, Chamberland JP, Paruthi J, Moon HS, Mantzoros CS. Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway. Diabetes Care. 2013 Apr; 36(4):935-42. PMID: 23193213; PMCID: PMC3609498.
  163. Kizer JR, Benkeser D, Arnold AM, Djousse L, Zieman SJ, Mukamal KJ, Tracy RP, Mantzoros CS, Siscovick DS, Gottdiener JS, Ix JH. Total and high-molecular-weight adiponectin and risk of coronary heart disease and ischemic stroke in older adults. J Clin Endocrinol Metab. 2013 Jan; 98(1):255-63. PMID: 23162097; PMCID: PMC3537098.
  164. Kizer JR, Benkeser D, Arnold AM, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Tracy RP, Mantzoros CS, Defilippi CR, Newman AB, Djousse L. Associations of total and high-molecular-weight adiponectin with all-cause and cardiovascular mortality in older persons: the Cardiovascular Health Study. Circulation. 2012 Dec 18; 126(25):2951-61. PMID: 23159554; PMCID: PMC3968250.
  165. Wedick NM, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam RM. The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial. Nutr J. 2012 Oct 19; 11:86. PMID: 23078574; PMCID: PMC3502342.
  166. Berthold HK, Berneis K, Mantzoros CS, Krone W, Gouni-Berthold I. Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive protein. Scand Cardiovasc J Suppl. 2013 Feb; 47(1):20-7. PMID: 23013513.
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  167. Aronis KN, Khan SM, Mantzoros CS. Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials. Am J Clin Nutr. 2012 Nov; 96(5):1093-9. PMID: 23053553; PMCID: PMC3471197.
  168. Sahin-Efe A, Katsikeris F, Mantzoros CS. Advances in adipokines. Metabolism. 2012 Dec; 61(12):1659-65. PMID: 23021039.
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  169. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism. 2012 Dec; 61(12):1725-38. PMID: 23018146; PMCID: PMC3614417.
  170. Khan SM, Hamnvik OP, Brinkoetter M, Mantzoros CS. Leptin as a modulator of neuroendocrine function in humans. Yonsei Med J. 2012 Jul 01; 53(4):671-9. PMID: 22665330; PMCID: PMC3381496.
  171. Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, Brinkoetter MT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D, Mantzoros CS. Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut. 2013 Apr; 62(4):561-70. PMID: 22735569.
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  172. Mantzoros CS. Leptin in relation to the lipodystrophy-associated metabolic syndrome. Diabetes Metab J. 2012 Jun; 36(3):181-9. PMID: 22737657; PMCID: PMC3380121.
  173. Foo JP, Mantzoros CS. Leptin in congenital or HIV-associated lipodystrophy and metabolic syndrome: a need for more mechanistic studies and large, randomized, placebo-controlled trials. Metabolism. 2012 Oct; 61(10):1331-6. PMID: 22592129.
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  174. Aronis KN, Foo JP, Chamberland JP, Mantzoros CS. Secretion patterns of circulating osteoprotegerin and response to acute and chronic energy deprivation in young healthy adults. J Clin Endocrinol Metab. 2012 Aug; 97(8):2765-72. PMID: 22563105; PMCID: PMC3410259.
  175. Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: a review of current evidence. Endocr Rev. 2012 Aug; 33(4):547-94. PMID: 22547160; PMCID: PMC3410224.
  176. Polyzos SA, Kountouras J, Mantzoros CS. Sulfated oxysterols as candidates for the treatment of nonalcoholic fatty liver disease. Metabolism. 2012 Jun; 61(6):755-8. PMID: 22386938.
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  177. Athanasoulia AP, Ising M, Pfister H, Mantzoros CS, Stalla GK, Sievers C. Distinct dopaminergic personality patterns in patients with prolactinomas: a comparison with nonfunctioning pituitary adenoma patients and age- and gender-matched controls. Neuroendocrinology. 2012; 96(3):204-11. PMID: 22343218.
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  178. Aronis KN, Mantzoros CS. A brief history of insulin resistance: from the first insulin radioimmunoassay to selectively targeting protein kinase C pathways. Metabolism. 2012 Apr; 61(4):445-9. PMID: 22304840.
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  179. Gordon CM, Mantzoros CS. Dietary calcium and body weight: what's the "skinny"? Metabolism. 2012 Feb; 61(2):137-9. PMID: 22269212.
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  180. Foo JP, Hamnvik OP, Mantzoros CS. Optimizing bone health in anorexia nervosa and hypothalamic amenorrhea: new trials and tribulations. Metabolism. 2012 Jul; 61(7):899-905. PMID: 22300837.
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  181. Lee DH, Huang H, Choi K, Mantzoros C, Kim YB. Selective PPAR? modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2012 Mar 01; 302(5):E552-60. PMID: 22215652; PMCID: PMC4116349.
  182. Polyzos SA, Kountouras J, Deretzi G, Zavos C, Mantzoros CS. The emerging role of endocrine disruptors in pathogenesis of insulin resistance: a concept implicating nonalcoholic fatty liver disease. Curr Mol Med. 2012 Jan; 12(1):68-82. PMID: 22082482.
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  183. Kizer JR, Arnold AM, Benkeser D, Ix JH, Djousse L, Zieman SJ, Barzilay JI, Tracy RP, Mantzoros CS, Siscovick DS, Mukamal KJ. Total and high-molecular-weight adiponectin and risk of incident diabetes in older people. Diabetes Care. 2012 Feb; 35(2):415-23. PMID: 22148099; PMCID: PMC3263897.
  184. Antoniadis AG, Petridou ET, Antonopoulos CN, Dessypris N, Panagopoulou P, Chamberland JP, Adami HO, Gogas H, Mantzoros CS. Insulin resistance in relation to melanoma risk. Melanoma Res. 2011 Dec; 21(6):541-6. PMID: 21946019.
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  185. Aronis KN, Vamvini MT, Chamberland JP, Sweeney LL, Brennan AM, Magkos F, Mantzoros CS. Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. Metabolism. 2012 Apr; 61(4):577-82. PMID: 22075273; PMCID: PMC3645917.
  186. Lee SH, Mantzoros C, Kim YB. Resveratrol: is selectivity opening the key to therapeutic effects? Metabolism. 2012 Mar; 61(3):289-90. PMID: 22075269.
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  187. Kang ES, Magkos F, Kim BS, Zhai R, Su L, Kim YS, Christiani DC, Lee HC, Mantzoros CS. Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients. J Clin Endocrinol Metab. 2012 Jan; 97(1):E129-35. PMID: 22049178; PMCID: PMC3251933.
  188. Stuebe AM, Mantzoros C, Kleinman K, Gillman MW, Rifas-Shiman S, Seely EW, Rich-Edwards J. Gestational glucose tolerance and maternal metabolic profile at 3 years postpartum. Obstet Gynecol. 2011 Nov; 118(5):1065-73. PMID: 22015874; PMCID: PMC3268071.
  189. Ahasic AM, Zhai R, Su L, Zhao Y, Aronis KN, Thompson BT, Mantzoros CS, Christiani DC. IGF1 and IGFBP3 in acute respiratory distress syndrome. Eur J Endocrinol. 2012 Jan; 166(1):121-9. PMID: 22004906; PMCID: PMC3757506.
  190. Moon HS, Chamberland JP, Mantzoros CS. Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C2C12 muscle and AML12 liver cell lines. Diabetologia. 2012 Jan; 55(1):215-25. PMID: 21997794; PMCID: PMC3780406.
  191. Moon HS, Chamberland JP, Aronis K, Tseleni-Balafouta S, Mantzoros CS. Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans. Mol Cancer Ther. 2011 Dec; 10(12):2234-43. PMID: 21980131; PMCID: PMC3237794.
  192. Mitsiades N, Pazaitou-Panayiotou K, Aronis KN, Moon HS, Chamberland JP, Liu X, Diakopoulos KN, Kyttaris V, Panagiotou V, Mylvaganam G, Tseleni-Balafouta S, Mantzoros CS. Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies. J Clin Endocrinol Metab. 2011 Dec; 96(12):E2023-8. PMID: 21937620; PMCID: PMC3232611.
  193. Moragianni VA, Aronis KN, Chamberland JP, Mantzoros CS. Short-term energy deprivation alters activin a and follistatin but not inhibin B levels of lean healthy women in a leptin-independent manner. J Clin Endocrinol Metab. 2011 Dec; 96(12):3750-8. PMID: 21917874; PMCID: PMC3232616.
  194. Wedick NM, Brennan AM, Sun Q, Hu FB, Mantzoros CS, van Dam RM. Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial. Nutr J. 2011 Sep 13; 10:93. PMID: 21914162; PMCID: PMC3180352.
  195. Aronis KN, Vamvini MT, Chamberland JP, Mantzoros CS. Circulating clusterin (apolipoprotein J) levels do not have any day/night variability and are positively associated with total and LDL cholesterol levels in young healthy individuals. J Clin Endocrinol Metab. 2011 Nov; 96(11):E1871-5. PMID: 21900379; PMCID: PMC3205900.
  196. Liu X, Hamnvik OP, Petrou M, Gong H, Chamberland JP, Christophi CA, Kales SN, Christiani DC, Mantzoros CS. Circulating lipocalin 2 is associated with body fat distribution at baseline but is not an independent predictor of insulin resistance: the prospective Cyprus Metabolism Study. Eur J Endocrinol. 2011 Nov; 165(5):805-12. PMID: 21885675.
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  197. Vamvini MT, Aronis KN, Chamberland JP, Mantzoros CS. Energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin A and follistatin but not myostatin in healthy males. J Clin Endocrinol Metab. 2011 Nov; 96(11):3416-23. PMID: 21865351; PMCID: PMC3205881.
  198. Foo JP, Mantzoros CS. The quest for the perfect biomarker of long-term glycemia: new studies, new trials and tribulations. Metabolism. 2011 Dec; 60(12):1651-4. PMID: 21820137.
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  199. Aronis KN, Kilim H, Chamberland JP, Breggia A, Rosen C, Mantzoros CS. Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin. J Clin Endocrinol Metab. 2011 Oct; 96(10):E1634-9. PMID: 21795455; PMCID: PMC3200235.
  200. Nagel JM, Brinkoetter M, Magkos F, Liu X, Chamberland JP, Shah S, Zhou J, Blackburn G, Mantzoros CS. Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 2012 Jan; 28(1):67-75. PMID: 21795022; PMCID: PMC3237820.
  201. Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Kim SY, Hamnvik OP, Koniaris A. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab. 2011 Oct; 301(4):E567-84. PMID: 21791620; PMCID: PMC3191548.
  202. Tsiodras S, Mantzoros CS. Drug-drug interactions in HIV medicine: a not so simple and straightforward road to the future. Metabolism. 2011 Nov; 60(11):1497-9. PMID: 21742352.
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  203. Sienkiewicz E, Magkos F, Aronis KN, Brinkoetter M, Chamberland JP, Chou S, Arampatzi KM, Gao C, Koniaris A, Mantzoros CS. Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women. Metabolism. 2011 Sep; 60(9):1211-21. PMID: 21741057.
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  204. Aronis KN, Joseph RJ, Blackburn GL, Mantzoros C. trans-Fatty acids, insulin resistance/diabetes, and cardiovascular disease risk: should policy decisions be based on observational cohort studies, or should we be waiting for results from randomized placebo-controlled trials? Metabolism. 2011 Jul; 60(7):901-5. PMID: 21684360.
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  205. Aronis KN, Diakopoulos KN, Fiorenza CG, Chamberland JP, Mantzoros CS. Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans. Diabetologia. 2011 Sep; 54(9):2358-67. PMID: 21660636; PMCID: PMC3733553.
  206. Moon HS, Matarese G, Brennan AM, Chamberland JP, Liu X, Fiorenza CG, Mylvaganam GH, Abanni L, Carbone F, Williams CJ, De Paoli AM, Schneider BE, Mantzoros CS. Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance. Diabetes. 2011 Jun; 60(6):1647-56. PMID: 21617185; PMCID: PMC3114380.
  207. Dalamaga M, Srinivas SK, Elovitz MA, Chamberland J, Mantzoros CS. Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study. Metabolism. 2011 Nov; 60(11):1539-44. PMID: 21632080; PMCID: PMC3178730.
  208. Lee YH, Magkos F, Mantzoros CS, Kang ES. Effects of leptin and adiponectin on pancreatic ß-cell function. Metabolism. 2011 Dec; 60(12):1664-72. PMID: 21632069.
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  209. Gialamas SP, Petridou ET, Tseleni-Balafouta S, Spyridopoulos TN, Matsoukis IL, Kondi-Pafiti A, Zografos G, Mantzoros CS. Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer. Metabolism. 2011 Nov; 60(11):1530-8. PMID: 21632074.
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  210. Shetty GK, Matarese G, Magkos F, Moon HS, Liu X, Brennan AM, Mylvaganam G, Sykoutri D, Depaoli AM, Mantzoros CS. Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet. Eur J Endocrinol. 2011 Aug; 165(2):249-54. PMID: 21602313; PMCID: PMC3159386.
  211. Alonso-Alonso M, Ziemke F, Magkos F, Barrios FA, Brinkoetter M, Boyd I, Rifkin-Graboi A, Yannakoulia M, Rojas R, Pascual-Leone A, Mantzoros CS. Brain responses to food images during the early and late follicular phase of the menstrual cycle in healthy young women: relation to fasting and feeding. Am J Clin Nutr. 2011 Aug; 94(2):377-84. PMID: 21593494; PMCID: PMC3142717.
  212. Brinkoetter M, Magkos F, Vamvini M, Mantzoros CS. Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E99-E104. PMID: 21505147; PMCID: PMC3129841.
  213. Kaklamani V, Yi N, Sadim M, Siziopikou K, Zhang K, Xu Y, Tofilon S, Agarwal S, Pasche B, Mantzoros C. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Med Genet. 2011 Apr 13; 12:52. PMID: 21489227; PMCID: PMC3089782.
  214. Kim SM, Cho GJ, Yannakoulia M, Hwang TG, Kim IH, Park EK, Mantzoros CS. Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations. Metabolism. 2011 Sep; 60(9):1294-9. PMID: 21489569.
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  215. Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K, Mantzoros CS. Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6585-90. PMID: 21464293; PMCID: PMC3080974.
  216. Kang ES, Magkos F, Sienkiewicz E, Mantzoros CS. Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans. Eur J Endocrinol. 2011 Jun; 164(6):911-7. PMID: 21422197; PMCID: PMC3104072.
  217. Kaklamani V, Yi N, Zhang K, Sadim M, Offit K, Oddoux C, Ostrer H, Mantzoros C, Pasche B. Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk. Metabolism. 2011 Sep; 60(9):1234-43. PMID: 21397927; PMCID: PMC3134585.
  218. Stuebe AM, Mantzoros C, Kleinman K, Gillman MW, Rifas-Shiman S, Gunderson EP, Rich-Edwards J. Duration of lactation and maternal adipokines at 3 years postpartum. Diabetes. 2011 Apr; 60(4):1277-85. PMID: 21350085; PMCID: PMC3064101.
  219. Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 01; 141(4):703-7. PMID: 21346100.
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  220. Aronis KN, Kim YB, Mantzoros CS. Clusterin (apolipoprotein J): wither link with diabetes and cardiometabolic risk? Metabolism. 2011 Jun; 60(6):747-8. PMID: 21333309.
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  221. Landberg R, Sun Q, Rimm EB, Cassidy A, Scalbert A, Mantzoros CS, Hu FB, van Dam RM. Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.S. women. J Nutr. 2011 Apr 01; 141(4):618-25. PMID: 21325476; PMCID: PMC3057665.
  222. Petridou ET, Sergentanis TN, Antonopoulos CN, Dessypris N, Matsoukis IL, Aronis K, Efremidis A, Syrigos C, Mantzoros CS. Insulin resistance: an independent risk factor for lung cancer? Metabolism. 2011 Aug; 60(8):1100-6. PMID: 21251684.
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  223. Nagel JM, Staffa J, Renner-Müller I, Horst D, Vogeser M, Langkamp M, Hoeflich A, Göke B, Kolligs FT, Mantzoros CS. Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice. Horm Cancer. 2010 Dec; 1(6):320-30. PMID: 21761363.
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  224. Choi KM, Yannakoulia M, Park MS, Cho GJ, Kim JH, Lee SH, Hwang TG, Yang SJ, Kim TN, Yoo HJ, Baik SH, Kim SM, Mantzoros CS. Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys: a 3-y prospective cohort study. Am J Clin Nutr. 2011 Jan; 93(1):19-26. PMID: 21106915; PMCID: PMC3001596.
  225. Baur DM, Klotsche J, Hamnvik OP, Sievers C, Pieper L, Wittchen HU, Stalla GK, Schmid RM, Kales SN, Mantzoros CS. Type 2 diabetes mellitus and medications for type 2 diabetes mellitus are associated with risk for and mortality from cancer in a German primary care cohort. Metabolism. 2011 Oct; 60(10):1363-71. PMID: 21081242.
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  226. Magkos F, Brennan A, Sweeney L, Kang ES, Doweiko J, Karchmer AW, Mantzoros CS. Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus-infected lipoatrophic men treated with pioglitazone: a pilot study. Metabolism. 2011 Jul; 60(7):1045-9. PMID: 21081243; PMCID: PMC3057303.
  227. Fiorenza CG, Chou SH, Mantzoros CS. Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol. 2011 Mar; 7(3):137-50. PMID: 21079616; PMCID: PMC3150735.
  228. Hamnvik OP, Liu X, Petrou M, Gong H, Chamberland JP, Kim EH, Christophi CA, Kales SN, Christiani DC, Mantzoros CS. Soluble leptin receptor and leptin are associated with baseline adiposity and metabolic risk factors, and predict adiposity, metabolic syndrome, and glucose levels at 2-year follow-up: the Cyprus Metabolism Prospective Cohort Study. Metabolism. 2011 Jul; 60(7):987-93. PMID: 21056886.
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  229. Taveras EM, Rifas-Shiman SL, Rich-Edwards JW, Mantzoros CS. Maternal short sleep duration is associated with increased levels of inflammatory markers at 3 years postpartum. Metabolism. 2011 Jul; 60(7):982-6. PMID: 21040938; PMCID: PMC3117066.
  230. Magkos F, Mantzoros CS. Body fat redistribution and metabolic abnormalities in HIV-infected patients on highly active antiretroviral therapy: novel insights into pathophysiology and emerging opportunities for treatment. Metabolism. 2011 Jun; 60(6):749-53. PMID: 20965525; PMCID: PMC3036773.
  231. Mantzoros CS. Accepting the torch. Metabolism. 2010 Oct; 59(10):1394-5. PMID: 20855035.
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  232. Moon HS, Chamberland JP, Diakopoulos KN, Fiorenza CG, Ziemke F, Schneider B, Mantzoros CS. Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans. Diabetes Care. 2011 Jan; 34(1):132-8. PMID: 20870968; PMCID: PMC3005478.
  233. Parker M, Rifas-Shiman SL, Belfort MB, Taveras EM, Oken E, Mantzoros C, Gillman MW. Gestational glucose tolerance and cord blood leptin levels predict slower weight gain in early infancy. J Pediatr. 2011 Feb; 158(2):227-33. PMID: 20855080; PMCID: PMC4270123.
  234. Nagel JM, Kriegl L, Horst D, Engel J, Gautam S, Mantzoros CS, Kirchner T, Göke B, Kolligs FT. ?-Catenin is an independent prognostic marker in early stage colorectal cancer. Int J Colorectal Dis. 2010 Nov; 25(11):1301-9. PMID: 20737155.
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  235. Scheer FA, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CS. Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov; 53(11):2401-5. PMID: 20703446; PMCID: PMC3111077.
  236. Sievers C, Klotsche J, Pieper L, Schneider HJ, März W, Wittchen HU, Stalla GK, Mantzoros C. Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients. Eur J Endocrinol. 2010 Oct; 163(4):699-708. PMID: 20685832.
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  237. Dardeno TA, Chou SH, Moon HS, Chamberland JP, Fiorenza CG, Mantzoros CS. Leptin in human physiology and therapeutics. Front Neuroendocrinol. 2010 Jul; 31(3):377-93. PMID: 20600241; PMCID: PMC2916735.
  238. Tsiodras S, Perelas A, Wanke C, Mantzoros CS. The HIV-1/HAART associated metabolic syndrome - novel adipokines, molecular associations and therapeutic implications. J Infect. 2010 Jul; 61(2):101-13. PMID: 20547180.
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  239. Chou SH, Tseleni-Balafouta S, Moon HS, Chamberland JP, Liu X, Kavantzas N, Mantzoros CS. Adiponectin receptor expression in human malignant tissues. Horm Cancer. 2010 Jun; 1(3):136-45. PMID: 21761356.
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  240. Taveras EM, Rifas-Shiman SL, Rich-Edwards JW, Gunderson EP, Stuebe AM, Mantzoros CS. Association of maternal short sleep duration with adiposity and cardiometabolic status at 3 years postpartum. Obesity (Silver Spring). 2011 Jan; 19(1):171-8. PMID: 20489690; PMCID: PMC3099421.
  241. Friberg E, Orsini N, Mantzoros CS, Wolk A. Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies. Br J Cancer. 2010 Jun 29; 103(1):127-31. PMID: 20485288; PMCID: PMC2905297.
  242. Dalamaga M, Crotty BH, Fargnoli J, Papadavid E, Lekka A, Triantafilli M, Karmaniolas K, Migdalis I, Dionyssiou-Asteriou A, Mantzoros CS. B-cell chronic lymphocytic leukemia risk in association with serum leptin and adiponectin: a case-control study in Greece. Cancer Causes Control. 2010 Sep; 21(9):1451-9. PMID: 20454844; PMCID: PMC3100743.
  243. Mantzoros CS, Sweeney L, Williams CJ, Oken E, Kelesidis T, Rifas-Shiman SL, Gillman MW. Maternal diet and cord blood leptin and adiponectin concentrations at birth. Clin Nutr. 2010 Oct; 29(5):622-6. PMID: 20363059; PMCID: PMC2916023.
  244. Kotsopoulos J, Tworoger SS, Campos H, Chung FL, Clevenger CV, Franke AA, Mantzoros CS, Ricchiuti V, Willett WC, Hankinson SE, Eliassen AH. Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies. Cancer Epidemiol Biomarkers Prev. 2010 Apr; 19(4):938-46. PMID: 20332276; PMCID: PMC2852492.
  245. Smart MC, Dedoussis G, Yiannakouris N, Grisoni ML, Dror GK, Yannakoulia M, Papoutsakis C, Louizou E, Mantzoros CS, Melistas L, Kontogianni MD, Cooper JA, Humphries SE, Talmud PJ. Genetic variation within IL18 is associated with insulin levels, insulin resistance and postprandial measures. Nutr Metab Cardiovasc Dis. 2011 Jul; 21(7):476-84. PMID: 20227263; PMCID: PMC3158674.
  246. Mantzoros CS. W(h)ither metreleptin for lipodystrophy and the metabolic syndrome? Endocr Pract. 2010 Mar-Apr; 16(2):162-6. PMID: 20350904.
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  247. Sun Q, Cornelis MC, Kraft P, Qi L, van Dam RM, Girman CJ, Laurie CC, Mirel DB, Gong H, Sheu CC, Christiani DC, Hunter DJ, Mantzoros CS, Hu FB. Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels. Hum Mol Genet. 2010 May 01; 19(9):1846-55. PMID: 20167575; PMCID: PMC2850621.
  248. Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010 Jan 19; 152(2):93-100. PMID: 20083828; PMCID: PMC2829242.
  249. Ruschke K, Fishbein L, Dietrich A, Klöting N, Tönjes A, Oberbach A, Fasshauer M, Jenkner J, Schön MR, Stumvoll M, Blüher M, Mantzoros CS. Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training. Eur J Endocrinol. 2010 Mar; 162(3):515-23. PMID: 19966034; PMCID: PMC2857401.
  250. Sun Q, van Dam RM, Meigs JB, Franco OH, Mantzoros CS, Hu FB. Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study. Diabetes. 2010 Mar; 59(3):611-8. PMID: 19959759; PMCID: PMC2828671.
  251. Lin J, Hu FB, Mantzoros C, Curhan GC. Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetes. Diabetologia. 2010 Feb; 53(2):263-7. PMID: 19921505; PMCID: PMC2809803.
  252. Fargnoli JL, Sun Q, Olenczuk D, Qi L, Zhu Y, Hu FB, Mantzoros CS. Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function. Eur J Endocrinol. 2010 Feb; 162(2):281-8. PMID: 19920090; PMCID: PMC2828059.
  253. Friberg E, Orsini N, Mantzoros CS, Wolk A. Coffee drinking and risk of endometrial cancer--a population-based cohort study. Int J Cancer. 2009 Nov 15; 125(10):2413-7. PMID: 19585497; PMCID: PMC2773380.
  254. Brennan AM, Sweeney LL, Liu X, Mantzoros CS. Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4-day period. Obesity (Silver Spring). 2010 Jun; 18(6):1176-82. PMID: 19910942; PMCID: PMC2998344.
  255. Ziemke F, Mantzoros CS. Adiponectin in insulin resistance: lessons from translational research. Am J Clin Nutr. 2010 Jan; 91(1):258S-261S. PMID: 19906806; PMCID: PMC2793112.
  256. Taplin ME, Regan MM, Ko YJ, Bubley GJ, Duggan SE, Werner L, Beer TM, Ryan CW, Mathew P, Tu SM, Denmeade SR, Oh WK, Sartor O, Mantzoros CS, Rittmaster R, Kantoff PW, Balk SP. Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. Clin Cancer Res. 2009 Nov 15; 15(22):7099-105. PMID: 19887483; PMCID: PMC3644858.
  257. Blüher S, Shah S, Mantzoros CS. Leptin deficiency: clinical implications and opportunities for therapeutic interventions. J Investig Med. 2009 Oct; 57(7):784-8. PMID: 19730134.
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  258. Melistas L, Mantzoros CS, Kontogianni M, Antonopoulou S, Ordovas JM, Yiannakouris N. Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women. Eur J Endocrinol. 2009 Dec; 161(6):845-52. PMID: 19755407; PMCID: PMC2896503.
  259. Petridou ET, Sergentanis TN, Dessypris N, Vlachantoni IT, Tseleni-Balafouta S, Pourtsidis A, Moschovi M, Polychronopoulou S, Athanasiadou-Piperopoulou F, Kalmanti M, Mantzoros CS. Serum adiponectin as a predictor of childhood non-Hodgkin's lymphoma: a nationwide case-control study. J Clin Oncol. 2009 Oct 20; 27(30):5049-55. PMID: 19738128; PMCID: PMC2799057.
  260. Hivert MF, Sun Q, Shrader P, Mantzoros CS, Meigs JB, Hu FB. Circulating IL-18 and the risk of type 2 diabetes in women. Diabetologia. 2009 Oct; 52(10):2101-8. PMID: 19669125; PMCID: PMC3758765.
  261. Tsiodras S, Poulia KA, Yannakoulia M, Chimienti SN, Wadhwa S, Karchmer AW, Mantzoros CS. Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy-induced metabolic syndrome and lipodystrophy. Metabolism. 2009 Jun; 58(6):854-9. PMID: 19375132; PMCID: PMC2829239.
  262. Ligibel JA, Giobbie-Hurder A, Olenczuk D, Campbell N, Salinardi T, Winer EP, Mantzoros CS. Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors. Cancer Causes Control. 2009 Oct; 20(8):1523-8. PMID: 19434504.
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  263. Li TY, Brennan AM, Wedick NM, Mantzoros C, Rifai N, Hu FB. Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes. J Nutr. 2009 Jul; 139(7):1333-8. PMID: 19420347; PMCID: PMC2696988.
  264. Khaodhiar L, Brennan AM, Lima C, Chan JL, Mantzoros CS, Manning WJ, Danias PG, Veves A. Effect of valsartan on left ventricular anatomy and systolic function and aortic elasticity. Metabolism. 2009 May; 58(5):682-8. PMID: 19375592.
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  265. Mantzoros CS. Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome? J Clin Endocrinol Metab. 2009 Apr; 94(4):1089-91. PMID: 19349474; PMCID: PMC2730231.
  266. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4453-8. PMID: 19255424; PMCID: PMC2657421.
  267. Brennan AM, Fargnoli JL, Williams CJ, Li T, Willett W, Kawachi I, Qi L, Hu FB, Mantzoros CS. Phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes. Diabetes Care. 2009 May; 32(5):926-31. PMID: 19223611; PMCID: PMC2671103.
  268. Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation. 2009 Mar 03; 119(8):1093-100. PMID: 19221219; PMCID: PMC2724471.
  269. Fasting MH, Oken E, Mantzoros CS, Rich-Edwards JW, Majzoub JA, Kleinman K, Rifas-Shiman SL, Vik T, Gillman MW. Maternal levels of corticotropin-releasing hormone during pregnancy in relation to adiponectin and leptin in early childhood. J Clin Endocrinol Metab. 2009 Apr; 94(4):1409-15. PMID: 19190112; PMCID: PMC2682476.
  270. Mantzoros CS, Rifas-Shiman SL, Williams CJ, Fargnoli JL, Kelesidis T, Gillman MW. Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study. Pediatrics. 2009 Feb; 123(2):682-9. PMID: 19171638; PMCID: PMC2761663.
  271. Blüher S, Mantzoros CS. Leptin in humans: lessons from translational research. Am J Clin Nutr. 2009 Mar; 89(3):991S-997S. PMID: 19176740; PMCID: PMC2667664.
  272. Magkos F, Yannakoulia M, Chan JL, Mantzoros CS. Management of the metabolic syndrome and type 2 diabetes through lifestyle modification. Annu Rev Nutr. 2009; 29:223-56. PMID: 19400751.
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  273. Dalamaga M, Migdalis I, Fargnoli JL, Papadavid E, Bloom E, Mitsiades N, Karmaniolas K, Pelecanos N, Tseleni-Balafouta S, Dionyssiou-Asteriou A, Mantzoros CS. Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. Cancer Causes Control. 2009 Jul; 20(5):625-33. PMID: 19051043; PMCID: PMC2720089.
  274. Sher DJ, Mantzoros C, Jacobus S, Regan MM, Lee GS, Oh WK. Absence of relationship between steroid hormone levels and prostate cancer tumor grade. Urology. 2009 Feb; 73(2):356-61; discussion 361-2. PMID: 19036418.
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  275. Brennan AM, Lee JH, Tsiodras S, Chan JL, Doweiko J, Chimienti SN, Wadhwa SG, Karchmer AW, Mantzoros CS. r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans. Eur J Endocrinol. 2009 Feb; 160(2):173-6. PMID: 19029226; PMCID: PMC2760959.
  276. Fargnoli JL, Fung TT, Olenczuk DM, Chamberland JP, Hu FB, Mantzoros CS. Adherence to healthy eating patterns is associated with higher circulating total and high-molecular-weight adiponectin and lower resistin concentrations in women from the Nurses' Health Study. Am J Clin Nutr. 2008 Nov; 88(5):1213-24. PMID: 18996855; PMCID: PMC4370425.
  277. Kaklamani VG, Wisinski KB, Sadim M, Gulden C, Do A, Offit K, Baron JA, Ahsan H, Mantzoros C, Pasche B. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA. 2008 Oct 01; 300(13):1523-31. PMID: 18827209; PMCID: PMC2628475.
  278. Sher DJ, Oh WK, Jacobus S, Regan MM, Lee GS, Mantzoros C. Relationship between serum adiponectin and prostate cancer grade. Prostate. 2008 Oct 01; 68(14):1592-8. PMID: 18646046.
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  279. Berthold HK, Giannakidou E, Krone W, Mantzoros CS, Gouni-Berthold I. The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes. Clin Chim Acta. 2009 Jan; 399(1-2):112-6. PMID: 18848536.
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  280. Dalamaga M, Karmaniolas K, Panagiotou A, Hsi A, Chamberland J, Dimas C, Lekka A, Mantzoros CS. Low circulating adiponectin and resistin, but not leptin, levels are associated with multiple myeloma risk: a case-control study. Cancer Causes Control. 2009 Mar; 20(2):193-9. PMID: 18814045.
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  281. Heidemann C, Sun Q, van Dam RM, Meigs JB, Zhang C, Tworoger SS, Mantzoros CS, Hu FB. Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Ann Intern Med. 2008 Sep 02; 149(5):307-16. PMID: 18765700; PMCID: PMC3874083.
  282. Dalamaga M, Karmaniolas K, Nikolaidou A, Chamberland J, Hsi A, Dionyssiou-Asteriou A, Mantzoros CS. Adiponectin and resistin are associated with risk for myelodysplastic syndrome, independently from the insulin-like growth factor-I (IGF-I) system. Eur J Cancer. 2008 Aug; 44(12):1744-53. PMID: 18515085.
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  283. Yannakoulia M, Yiannakouris N, Melistas L, Fappa E, Vidra N, Kontogianni MD, Mantzoros CS. Dietary factors associated with plasma high molecular weight and total adiponectin levels in apparently healthy women. Eur J Endocrinol. 2008 Oct; 159(4):R5-10. PMID: 18593824.
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  284. Heidemann C, Schulze MB, Franco OH, van Dam RM, Mantzoros CS, Hu FB. Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women. Circulation. 2008 Jul 15; 118(3):230-7. PMID: 18574045; PMCID: PMC2748772.
  285. Yannakoulia M, Yiannakouris N, Melistas L, Kontogianni MD, Malagaris I, Mantzoros CS. A dietary pattern characterized by high consumption of whole-grain cereals and low-fat dairy products and low consumption of refined cereals is positively associated with plasma adiponectin levels in healthy women. Metabolism. 2008 Jun; 57(6):824-30. PMID: 18502266.
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  286. Orsini N, Mantzoros CS, Wolk A. Association of physical activity with cancer incidence, mortality, and survival: a population-based study of men. Br J Cancer. 2008 Jun 03; 98(11):1864-9. PMID: 18506190; PMCID: PMC2410104.
  287. Jacobus S, Sher DJ, Regan MM, Chamberland J, Oh WK, Mantzoros C. Association between serum adiponectin and prostate cancer risk. J Clin Oncol. 2008 May 20; 26(15_suppl):5147. PMID: 27948194.
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  288. Kaklamani VG, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, Ahsan H, Pasche B, Mantzoros C. Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Cancer Res. 2008 May 01; 68(9):3178-84. PMID: 18451143; PMCID: PMC2685173.
  289. Taplin ME, Manola J, Oh WK, Kantoff PW, Bubley GJ, Smith M, Barb D, Mantzoros C, Gelmann EP, Balk SP. A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormones. BJU Int. 2008 May; 101(9):1084-9. PMID: 18399827.
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  290. Chan JL, Williams CJ, Raciti P, Blakeman J, Kelesidis T, Kelesidis I, Johnson ML, Thorner MO, Mantzoros CS. Leptin does not mediate short-term fasting-induced changes in growth hormone pulsatility but increases IGF-I in leptin deficiency states. J Clin Endocrinol Metab. 2008 Jul; 93(7):2819-27. PMID: 18445667; PMCID: PMC2453057.
  291. Petridou ET, Mitsiades N, Gialamas S, Angelopoulos M, Skalkidou A, Dessypris N, Hsi A, Lazaris N, Polyzos A, Syrigos C, Brennan AM, Tseleni-Balafouta S, Mantzoros CS. Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies. Oncology. 2007; 73(3-4):261-9. PMID: 18424891.
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  292. Gouni-Berthold I, Berthold HK, Mantzoros CS, Böhm M, Krone W. Sex disparities in the treatment and control of cardiovascular risk factors in type 2 diabetes. Diabetes Care. 2008 Jul; 31(7):1389-91. PMID: 18375411; PMCID: PMC2453666.
  293. Dalamaga M, Nikolaidou A, Karmaniolas K, Hsi A, Chamberland J, Dionyssiou-Asteriou A, Mantzoros CS. Circulating adiponectin and leptin in relation to myelodysplastic syndrome: a case-control study. Oncology. 2007; 73(1-2):26-32. PMID: 18337619.
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  294. Williams CJ, Mitsiades N, Sozopoulos E, Hsi A, Wolk A, Nifli AP, Tseleni-Balafouta S, Mantzoros CS. Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors. Endocr Relat Cancer. 2008 Mar; 15(1):289-99. PMID: 18310295.
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  295. Blüher S, Bullen J, Mantzoros CS. Altered levels of adiponectin and adiponectin receptors may underlie the effect of ciliary neurotrophic factor (CNTF) to enhance insulin sensitivity in diet-induced obese mice. Horm Metab Res. 2008 Mar; 40(3):225-7. PMID: 18425718; PMCID: PMC2739980.
  296. Hwang JJ, Chan JL, Ntali G, Malkova D, Mantzoros CS. Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide: interventional studies in humans. Diabetes Care. 2008 May; 31(5):945-51. PMID: 18252898; PMCID: PMC2753255.
  297. Chan JL, Wong SL, Mantzoros CS. Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity. Clin Pharmacokinet. 2008; 47(11):753-64. PMID: 18840030; PMCID: PMC2737404.
  298. Higgins LS, Mantzoros CS. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008; 2008:936906. PMID: 18769500; PMCID: PMC2522386.
  299. Williams CJ, Fargnoli JL, Hwang JJ, van Dam RM, Blackburn GL, Hu FB, Mantzoros CS. Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes: a prospective cohort study. Diabetes Care. 2008 Mar; 31(3):504-7. PMID: 18070989; PMCID: PMC2737446.
  300. Barb D, Neuwirth A, Mantzoros CS, Balk SP. Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway. Endocr Relat Cancer. 2007 Dec; 14(4):995-1005. PMID: 18045951.
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  301. Blüher S, Mantzoros CS. Leptin in reproduction. Curr Opin Endocrinol Diabetes Obes. 2007 Dec; 14(6):458-64. PMID: 17982352.
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  302. Gouni-Berthold I, Berthold HK, Gylling H, Hallikainen M, Giannakidou E, Stier S, Ko Y, Patel D, Soutar AK, Seedorf U, Mantzoros CS, Plat J, Krone W. Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men. Atherosclerosis. 2008 May; 198(1):198-207. PMID: 17980884.
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  303. Gillman MW, Mantzoros CS. Breast-feeding, adipokines, and childhood obesity. Epidemiology. 2007 Nov; 18(6):730-2. PMID: 18049187.
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  304. Gouni-Berthold I, Berthold HK, Chamberland JP, Krone W, Mantzoros CS. Short-term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men. Clin Endocrinol (Oxf). 2008 Apr; 68(4):536-41. PMID: 17973945.
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  305. Blüher M, Williams CJ, Klöting N, Hsi A, Ruschke K, Oberbach A, Fasshauer M, Berndt J, Schön MR, Wolk A, Stumvoll M, Mantzoros CS. Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training. Diabetes Care. 2007 Dec; 30(12):3110-5. PMID: 17878241; PMCID: PMC2732345.
  306. Barb D, Williams CJ, Neuwirth AK, Mantzoros CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr. 2007 Sep; 86(3):s858-66. PMID: 18265479.
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  307. Spentzos D, Cannistra SA, Grall F, Levine DA, Pillay K, Libermann TA, Mantzoros CS. IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer. Endocr Relat Cancer. 2007 Sep; 14(3):781-90. PMID: 17914107.
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  308. Tworoger SS, Mantzoros C, Hankinson SE. Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Obesity (Silver Spring). 2007 Sep; 15(9):2217-24. PMID: 17890489.
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  309. Larsson SC, Mantzoros CS, Wolk A. Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer. 2007 Aug 15; 121(4):856-62. PMID: 17397032.
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  310. Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem. 2007 Aug 10; 282(32):23672-8. PMID: 17556363.
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  311. Mantzoros CS, Trakatelli M, Gogas H, Dessypris N, Stratigos A, Chrousos GP, Petridou ET. Circulating adiponectin levels in relation to melanoma: a case-control study. Eur J Cancer. 2007 Jun; 43(9):1430-6. PMID: 17512191.
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  312. Sweeney LL, Brennan AM, Mantzoros CS. The role of adipokines in relation to HIV lipodystrophy. AIDS. 2007 May 11; 21(8):895-904. PMID: 17457082.
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  313. Friberg E, Orsini N, Mantzoros CS, Wolk A. Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia. 2007 Jul; 50(7):1365-74. PMID: 17476474.
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  314. Alevizos I, Misra J, Bullen J, Basso G, Kelleher J, Mantzoros C, Stephanopoulos G. Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice. Cell Cycle. 2007 Jul 01; 6(13):1631-8. PMID: 17603298.
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  315. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50. PMID: 17416903.
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  316. Chan JL, Wong SL, Orlova C, Raciti P, Mantzoros CS. Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay. J Clin Endocrinol Metab. 2007 Jun; 92(6):2307-11. PMID: 17405837.
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  317. Spyridopoulos TN, Petridou ET, Skalkidou A, Dessypris N, Chrousos GP, Mantzoros CS. Low adiponectin levels are associated with renal cell carcinoma: a case-control study. Int J Cancer. 2007 Apr 01; 120(7):1573-8. PMID: 17205522.
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  318. Brennan AM, Li TY, Kelesidis I, Gavrila A, Hu FB, Mantzoros CS. Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: a prospective cohort study. Diabetologia. 2007 Jun; 50(6):1178-85. PMID: 17372717.
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  319. Williams CJ, Hu FB, Patel SR, Mantzoros CS. Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetes. Diabetes Care. 2007 May; 30(5):1233-40. PMID: 17322482.
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  320. Friberg E, Mantzoros CS, Wolk A. Diabetes and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2007 Feb; 16(2):276-80. PMID: 17301260.
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  321. Brennan AM, Mantzoros CS. Leptin and adiponectin: their role in diabetes. Curr Diab Rep. 2007 Feb; 7(1):1-2. PMID: 17254509.
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  322. Michalakis K, Williams CJ, Mitsiades N, Blakeman J, Balafouta-Tselenis S, Giannopoulos A, Mantzoros CS. Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev. 2007 Feb; 16(2):308-13. PMID: 17301264.
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  323. Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Kaprara A, Blakeman J, Vainas I, Mpousoulegas A, Williams CJ, Mantzoros C. Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer. Eur J Endocrinol. 2007 Feb; 156(2):187-94. PMID: 17287408.
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  324. Blüher M, Brennan AM, Kelesidis T, Kratzsch J, Fasshauer M, Kralisch S, Williams CJ, Mantzoros CS. Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care. 2007 Feb; 30(2):280-5. PMID: 17259495.
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  325. Tworoger SS, Eliassen AH, Kelesidis T, Colditz GA, Willett WC, Mantzoros CS, Hankinson SE. Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab. 2007 Apr; 92(4):1510-6. PMID: 17213279.
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  326. Matarese G, Mantzoros C, La Cava A. Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis. Curr Pharm Des. 2007; 13(36):3676-80. PMID: 18220805.
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  327. Eliassen AH, Tworoger SS, Mantzoros CS, Pollak MN, Hankinson SE. Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women. Cancer Epidemiol Biomarkers Prev. 2007 Jan; 16(1):161-4. PMID: 17220346.
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  328. Chan JL, Mietus JE, Raciti PM, Goldberger AL, Mantzoros CS. Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans. Clin Endocrinol (Oxf). 2007 Jan; 66(1):49-57. PMID: 17201801.
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  329. Körner A, Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Williams CJ, Kaprara A, Bullen J, Neuwirth A, Tseleni S, Mitsiades N, Kiess W, Mantzoros CS. Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies. J Clin Endocrinol Metab. 2007 Mar; 92(3):1041-8. PMID: 17192291.
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  330. Bullen JW, Bluher S, Kelesidis T, Mantzoros CS. Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1079-86. PMID: 17164441.
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  331. Mamalakis G, Kiriakakis M, Tsibinos G, Hatzis C, Flouri S, Mantzoros C, Kafatos A. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharmacol Biochem Behav. 2006 Oct; 85(2):474-9. PMID: 17126386.
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  332. Friberg E, Mantzoros CS, Wolk A. Physical activity and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev. 2006 Nov; 15(11):2136-40. PMID: 17057024.
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  333. Dal Maso L, La Vecchia C, Augustin LS, Mantzoros CS, Kendall CW, Franceschi S. Relationship between a wide range of alcohol consumptions, components of the insulin-like growth factor system and adiponectin. Eur J Clin Nutr. 2007 Feb; 61(2):221-5. PMID: 16969380.
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  334. Barb D, Pazaitou-Panayiotou K, Mantzoros CS. Adiponectin: a link between obesity and cancer. Expert Opin Investig Drugs. 2006 Aug; 15(8):917-31. PMID: 16859394.
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  335. Mantzoros CS, Williams CJ, Manson JE, Meigs JB, Hu FB. Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. Am J Clin Nutr. 2006 Aug; 84(2):328-35. PMID: 16895879.
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  336. Qi L, Meigs JB, Liu S, Manson JE, Mantzoros C, Hu FB. Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes. Diabetes Care. 2006 Jul; 29(7):1501-5. PMID: 16801569.
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  337. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006 Jun 15; 176(12):7745-52. PMID: 16751422.
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  338. Brennan AM, Mantzoros CS. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2006 Jun; 2(6):318-27. PMID: 16932309.
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  339. Chan JL, Matarese G, Shetty GK, Raciti P, Kelesidis I, Aufiero D, De Rosa V, Perna F, Fontana S, Mantzoros CS. Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8481-6. PMID: 16714386; PMCID: PMC1482518.
  340. Kelesidis I, Kelesidis T, Mantzoros CS. Adiponectin and cancer: a systematic review. Br J Cancer. 2006 May 08; 94(9):1221-5. PMID: 16570048; PMCID: PMC2361397.
  341. Qi L, Doria A, Manson JE, Meigs JB, Hunter D, Mantzoros CS, Hu FB. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes. 2006 May; 55(5):1512-6. PMID: 16644713.
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  342. Lee JH, Chan JL, Sourlas E, Raptopoulos V, Mantzoros CS. Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab. 2006 Jul; 91(7):2605-11. PMID: 16636130.
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  343. Zhao D, Zhan Y, Zeng H, Moyer MP, Mantzoros CS, Pothoulakis C. Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. J Cell Biochem. 2006 Apr 15; 97(6):1317-27. PMID: 16552751.
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  344. Zhang YY, Gottardo L, Mlynarski W, Frazier W, Nolan D, Duffy J, Marescotti MC, Gervino EV, Johnstone MT, Mantzoros CS, Avogaro A, Doria A. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. Atherosclerosis. 2007 Mar; 191(1):121-7. PMID: 16580675.
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  345. Blüher M, Bullen JW, Lee JH, Kralisch S, Fasshauer M, Klöting N, Niebauer J, Schön MR, Williams CJ, Mantzoros CS. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. J Clin Endocrinol Metab. 2006 Jun; 91(6):2310-6. PMID: 16551730.
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  346. Kelesidis T, Mantzoros CS. The emerging role of leptin in humans. Pediatr Endocrinol Rev. 2006 Mar; 3(3):239-48. PMID: 16639389.
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  347. Kelesidis I, Mantzoros CS. Leptin and its emerging role in children and adolescents. Clin Pediatr Endocrinol. 2006; 15(1):1-14. PMID: 24790314; PMCID: PMC4004898.
  348. Qi L, van Dam RM, Liu S, Franz M, Mantzoros C, Hu FB. Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women. Diabetes Care. 2006 Feb; 29(2):207-11. PMID: 16443861.
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  349. Chan JL, Mun EC, Stoyneva V, Mantzoros CS, Goldfine AB. Peptide YY levels are elevated after gastric bypass surgery. Obesity (Silver Spring). 2006 Feb; 14(2):194-8. PMID: 16571843.
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  350. Petridou E, Mantzoros CS, Dessypris N, Dikalioti SK, Trichopoulos D. Adiponectin in relation to childhood myeloblastic leukaemia. Br J Cancer. 2006 Jan 16; 94(1):156-60. PMID: 16404369; PMCID: PMC2361080.
  351. Tsiodras S, Mantzoros C. Leptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic Implications. Am J Infect Dis. 2006; 2(3):141-152. PMID: 17183414.
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  352. Chan JL, Stoyneva V, Kelesidis T, Raciti P, Mantzoros CS. Peptide YY levels are decreased by fasting and elevated following caloric intake but are not regulated by leptin. Diabetologia. 2006 Jan; 49(1):169-73. PMID: 16362815.
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  353. Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst. 2005 Nov 16; 97(22):1688-94. PMID: 16288122.
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  354. Chan JL, Mantzoros CS. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet. 2005 Jul 2-8; 366(9479):74-85. PMID: 15993236.
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  355. Raab RM, Bullen J, Kelleher J, Mantzoros C, Stephanopoulos G. Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction. Nutr Metab (Lond). 2005 Jun 28; 2:15. PMID: 15985155; PMCID: PMC1201568.
  356. Barb D, Wadhwa SG, Kratzsch J, Gavrila A, Chan JL, Williams CJ, Karchmer AW, Mantzoros CS. Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome. J Clin Endocrinol Metab. 2005 Sep; 90(9):5324-8. PMID: 15956078.
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  357. Shai I, Schulze MB, Manson JE, Rexrode KM, Stampfer MJ, Mantzoros C, Hu FB. A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes. Diabetes Care. 2005 Jun; 28(6):1376-82. PMID: 15920055.
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  358. Mantzoros CS, Li T, Manson JE, Meigs JB, Hu FB. Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes. J Clin Endocrinol Metab. 2005 Aug; 90(8):4542-8. PMID: 15914524.
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  359. Matarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol. 2005 Mar 15; 174(6):3137-42. PMID: 15749839.
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  360. Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou S, Chrousos G, Trichopoulos D. Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf). 2005 Mar; 62(3):366-71. PMID: 15730421.
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  361. Gavrila A, Hsu W, Tsiodras S, Doweiko J, Gautam S, Martin L, Moses AC, Karchmer AW, Mantzoros CS. Improvement in highly active antiretroviral therapy-induced metabolic syndrome by treatment with pioglitazone but not with fenofibrate: a 2 x 2 factorial, randomized, double-blinded, placebo-controlled trial. Clin Infect Dis. 2005 Mar 01; 40(5):745-9. PMID: 15714423.
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  362. Shea SA, Hilton MF, Orlova C, Ayers RT, Mantzoros CS. Independent circadian and sleep/wake regulation of adipokines and glucose in humans. J Clin Endocrinol Metab. 2005 May; 90(5):2537-44. PMID: 15687326; PMCID: PMC2885832.
  363. Chan JL, Bullen J, Stoyneva V, Depaoli AM, Addy C, Mantzoros CS. Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess. J Clin Endocrinol Metab. 2005 Mar; 90(3):1618-24. PMID: 15613407.
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  364. Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, Kahn BB, Mantzoros CS. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. J Clin Endocrinol Metab. 2005 Mar; 90(3):1625-31. PMID: 15613409.
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  365. Mantzoros C, Petridou E, Alexe DM, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Shetty G, Gavrila A, Kedikoglou S, Chrousos G, Trichopoulos D. Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns. Eur J Endocrinol. 2004 Dec; 151(6):741-6. PMID: 15588241.
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  366. Gavrila A, Chan JL, Miller LC, Heist K, Yiannakouris N, Mantzoros CS. Circulating melanin-concentrating hormone, agouti-related protein, and alpha-melanocyte-stimulating hormone levels in relation to body composition: alterations in response to food deprivation and recombinant human leptin administration. J Clin Endocrinol Metab. 2005 Feb; 90(2):1047-54. PMID: 15546902.
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  367. Lee JH, Bullen JW, Stoyneva VL, Mantzoros CS. Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E625-32. PMID: 15522996.
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  368. Blüher S, Moschos S, Bullen J, Kokkotou E, Maratos-Flier E, Wiegand SJ, Sleeman MW, Sleemann MW, Mantzoros CS. Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice. Diabetes. 2004 Nov; 53(11):2787-96. PMID: 15504958.
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  369. Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care. 2004 Oct; 27(10):2450-7. PMID: 15451915.
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  370. Bullen JW, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab. 2004 Oct; 287(4):E662-70. PMID: 15361355.
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  371. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med. 2004 Sep 02; 351(10):987-97. PMID: 15342807.
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  372. Blüher S, Mantzoros CS. The role of leptin in regulating neuroendocrine function in humans. J Nutr. 2004 Sep; 134(9):2469S-2474S. PMID: 15333744.
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  373. Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS. Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clin Endocrinol (Oxf). 2004 Sep; 61(3):332-8. PMID: 15355449.
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  374. Yiannakouris N, Melistas L, Kontogianni M, Heist K, Mantzoros CS. The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek caucasians. J Endocrinol Invest. 2004 Sep; 27(8):714-20. PMID: 15636422.
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  375. Petridou E, Skalkidou A, Dessypris N, Kedikoglou S, Mantzoros C, Chroussos G, Trichopoulos D. Growth velocity during the first postnatal week of life is not related to adiponectin or leptin. Paediatr Perinat Epidemiol. 2004 Sep; 18(5):395. PMID: 15367327.
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  376. Raji A, Gerhard-Herman MD, Warren M, Silverman SG, Raptopoulos V, Mantzoros CS, Simonson DC. Insulin resistance and vascular dysfunction in nondiabetic Asian Indians. J Clin Endocrinol Metab. 2004 Aug; 89(8):3965-72. PMID: 15292334.
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  377. Wong SL, DePaoli AM, Lee JH, Mantzoros CS. Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates. J Clin Endocrinol Metab. 2004 Jun; 89(6):2672-7. PMID: 15181040.
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  378. Stamatiadis DN, Chan JL, Cogswell R, Stefanopoulou HC, Bullen J, Katsilambros N, Stathakis CP, Mantzoros CS. Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis. Clin Endocrinol (Oxf). 2004 Apr; 60(4):434-41. PMID: 15049957.
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  379. Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe DM, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, Trichopoulos D. Adiponectin and breast cancer risk. J Clin Endocrinol Metab. 2004 Mar; 89(3):1102-7. PMID: 15001594.
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  380. Dal Maso L, Augustin LS, Karalis A, Talamini R, Franceschi S, Trichopoulos D, Mantzoros CS, La Vecchia C. Circulating adiponectin and endometrial cancer risk. J Clin Endocrinol Metab. 2004 Mar; 89(3):1160-3. PMID: 15001602.
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  381. Gale SM, Castracane VD, Mantzoros CS. Energy homeostasis, obesity and eating disorders: recent advances in endocrinology. J Nutr. 2004 Feb; 134(2):295-8. PMID: 14747663.
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  382. Chan JL, Bullen J, Lee JH, Yiannakouris N, Mantzoros CS. Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects. J Clin Endocrinol Metab. 2004 Jan; 89(1):335-43. PMID: 14715869.
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  383. Wong ML, Licinio J, Yildiz BO, Mantzoros CS, Prolo P, Kling M, Gold PW. Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments. J Clin Endocrinol Metab. 2004 Jan; 89(1):258-65. PMID: 14715859.
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  384. Blüher S, Ziotopoulou M, Bullen JW, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes. 2004 Jan; 53(1):82-90. PMID: 14693701.
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  385. Acromite M, Ziotopoulou M, Orlova C, Mantzoros C. Increased leptin levels in preeclampsia: associations with BMI, estrogen and SHBG levels. Hormones (Athens). 2004 Jan-Mar; 3(1):46-52. PMID: 16982577.
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  386. Welt CK, Schneyer AL, Heist K, Mantzoros CS. Leptin and soluble leptin receptor in follicular fluid. J Assist Reprod Genet. 2003 Dec; 20(12):495-501. PMID: 15035548; PMCID: PMC3455309.
  387. Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C, Mantzoros CS. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab. 2003 Oct; 88(10):4823-31. PMID: 14557461.
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  388. Yiannakouris N, Melistas L, Yannakoulia M, Mungal K, Mantzoros CS. The-2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects. Hormones (Athens). 2003 Oct-Dec; 2(4):229-36. PMID: 17003027.
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  389. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, Orlova C, Mantzoros CS. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab. 2003 Oct; 88(10):4848-56. PMID: 14557464.
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  390. Papathanassoglou ED, Movnihan JA, Dafni O, Mantzoros CS, Ackerman MH. Association of proinflammatory molecules with apoptotic markers and survival in critically ill multiple organ dysfunction patients. Biol Res Nurs. 2003 Oct; 5(2):129-41. PMID: 14531217.
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  391. Mullington JM, Chan JL, Van Dongen HP, Szuba MP, Samaras J, Price NJ, Meier-Ewert HK, Dinges DF, Mantzoros CS. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J Neuroendocrinol. 2003 Sep; 15(9):851-4. PMID: 12899679.
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  392. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, Mantzoros CS. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res. 2003 Sep; 11(9):1048-54. PMID: 12972674.
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  393. Spentzos D, Mantzoros C, Regan MM, Morrissey ME, Duggan S, Flickner-Garvey S, McCormick H, DeWolf W, Balk S, Bubley GJ. Minimal effect of a low-fat/high soy diet for asymptomatic, hormonally naive prostate cancer patients. Clin Cancer Res. 2003 Aug 15; 9(9):3282-7. PMID: 12960113.
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  394. Gavrila A, Tsiodras S, Doweiko J, Nagy GS, Brodovicz K, Hsu W, Karchmer AW, Mantzoros CS. Exercise and vitamin E intake are independently associated with metabolic abnormalities in human immunodeficiency virus-positive subjects: a cross-sectional study. Clin Infect Dis. 2003 Jun 15; 36(12):1593-601. PMID: 12802761.
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  395. Gavrila A, Peng CK, Chan JL, Mietus JE, Goldberger AL, Mantzoros CS. Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab. 2003 Jun; 88(6):2838-43. PMID: 12788897.
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  396. Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest. 2003 May; 111(9):1409-21. PMID: 12727933; PMCID: PMC154448.
  397. Leow MK, Addy CL, Mantzoros CS. Clinical review 159: Human immunodeficiency virus/highly active antiretroviral therapy-associated metabolic syndrome: clinical presentation, pathophysiology, and therapeutic strategies. J Clin Endocrinol Metab. 2003 May; 88(5):1961-76. PMID: 12727939.
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  398. Yannakoulia M, Yiannakouris N, Blüher S, Matalas AL, Klimis-Zacas D, Mantzoros CS. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab. 2003 Apr; 88(4):1730-6. PMID: 12679465.
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  399. Nagy GS, Tsiodras S, Martin LD, Avihingsanon A, Gavrila A, Hsu WC, Karchmer AW, Mantzoros CS. Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentrations of leptin. Clin Infect Dis. 2003 Mar 15; 36(6):795-802. PMID: 12627366.
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  400. Mykoniatis A, Anton PM, Wlk M, Wang CC, Ungsunan L, Blüher S, Venihaki M, Simeonidis S, Zacks J, Zhao D, Sougioultzis S, Karalis K, Mantzoros C, Pothoulakis C. Leptin mediates Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology. 2003 Mar; 124(3):683-91. PMID: 12612907.
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  401. Petridou E, Mantzoros C, Dessypris N, Koukoulomatis P, Addy C, Voulgaris Z, Chrousos G, Trichopoulos D. Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece. J Clin Endocrinol Metab. 2003 Mar; 88(3):993-7. PMID: 12629074.
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  402. Addy CL, Gavrila A, Tsiodras S, Brodovicz K, Karchmer AW, Mantzoros CS. Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J Clin Endocrinol Metab. 2003 Feb; 88(2):627-36. PMID: 12574192.
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  403. Roemmich JN, Clark PA, Mantzoros CS, Gurgol CM, Weltman A, Rogol AD. Relationship of leptin to bone mineralization in children and adolescents. J Clin Endocrinol Metab. 2003 Feb; 88(2):599-604. PMID: 12574187.
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  404. Bubley GJ, Balk SP, Regan MM, Duggan S, Morrissey ME, Dewolf WC, Salgami E, Mantzoros C. Serum levels of insulin-like growth factor-1 and insulin-like growth factor-1 binding proteins after radical prostatectomy. J Urol. 2002 Nov; 168(5):2249-52. PMID: 12394769.
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  405. Chan JL, Blüher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes. 2002 Jul; 51(7):2105-12. PMID: 12086939.
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  406. Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes. 2002 May; 51(5):1337-45. PMID: 11978628.
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  407. Christou H, Serdy S, Mantzoros CS. Leptin in relation to growth and developmental processes in the fetus. Semin Reprod Med. 2002 May; 20(2):123-30. PMID: 12087497.
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  408. Moschos S, Chan JL, Mantzoros CS. Leptin and reproduction: a review. Fertil Steril. 2002 Mar; 77(3):433-44. PMID: 11872190.
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  409. Moschos SJ, Mantzoros CS. The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology. 2002; 63(4):317-32. PMID: 12417786.
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  410. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, Mantzoros CS. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab. 2001 Sep; 86(9):4434-9. PMID: 11549688.
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  411. Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S, Elashoff RM, Cogswell RJ, Negro P, Liberty V, Wong ML, Veldhuis J, Ozdemir IC, Gold PW, Flier JS, Licinio J. Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab. 2001 Jul; 86(7):3284-91. PMID: 11443202.
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  412. Mantzoros CS. The role of leptin and hypothalamic neuropeptides in energy homeostasis: update on leptin in obesity. Growth Horm IGF Res. 2001 Jun; 11 Suppl A:S85-9. PMID: 11527094.
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  413. Christou H, Connors JM, Ziotopoulou M, Hatzidakis V, Papathanassoglou E, Ringer SA, Mantzoros CS. Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. J Clin Endocrinol Metab. 2001 Feb; 86(2):935-8. PMID: 11158070.
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  414. Papathanassoglou ED, Moynihan JA, Ackerman MH, Mantzoros CS. Serum leptin levels are higher but are not independently associated with severity or mortality in the multiple organ dysfunction/systemic inflammatory response syndrome: a matched case control and a longitudinal study. Clin Endocrinol (Oxf). 2001 Feb; 54(2):225-33. PMID: 11207638.
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  415. Kuper H, Mantzoros C, Lagiou P, Tzonou A, Tamimi R, Mucci L, Benetou V, Spanos E, Stuver SO, Trichopoulos D. Estrogens, testosterone and sex hormone binding globulin in relation to liver cancer in men. Oncology. 2001; 60(4):355-60. PMID: 11408804.
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  416. Chan JL, Mantzoros CS. Leptin and the hypothalamic-pituitary regulation of the gonadotropin-gonadal axis. Pituitary. 2001 Jan-Apr; 4(1-2):87-92. PMID: 11824513.
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  417. Kontoyiannis DP, Bodey GP, Mantzoros CS. Fluconazole vs. amphotericin B for the management of candidaemia in adults: a meta-analysis. Mycoses. 2001; 44(5):125-35. PMID: 11486448.
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  418. Petridou E, Skalkidou A, Dessypris N, Moustaki M, Mantzoros C, Spanos E, Trichopoulos D. Insulin-like growth factor binding protein-3 predicts survival from acute childhood leukemia. Oncology. 2001; 60(3):252-7. PMID: 11340377.
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  419. Wolk A, Andersson SO, Mantzoros CS, Trichopoulos D, Adami HO. Can measurements of IGF-1 and IGFBP-3 improve the sensitivity of prostate-cancer screening? Lancet. 2000 Dec 02; 356(9245):1902-3. PMID: 11130391.
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  420. Jimerson DC, Mantzoros C, Wolfe BE, Metzger ED. Decreased serum leptin in bulimia nervosa. J Clin Endocrinol Metab. 2000 Dec; 85(12):4511-4. PMID: 11134100.
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  421. Ziotopoulou M, Erani DM, Hileman SM, Bjørbaek C, Mantzoros CS. Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling. Diabetes. 2000 Nov; 49(11):1890-6. PMID: 11078456.
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  422. Mantzoros CS, Flier JS. Editorial: leptin as a therapeutic agent--trials and tribulations. J Clin Endocrinol Metab. 2000 Nov; 85(11):4000-2. PMID: 11095422.
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  423. Ziotopoulou M, Mantzoros CS, Hileman SM, Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2000 Oct; 279(4):E838-45. PMID: 11001766.
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  424. Gordon CM, Emans SJ, DuRant RH, Mantzoros C, Grace E, Harper GP, Majzoub JA. Endocrinologic and psychological effects of short-term dexamethasone in anorexia nervosa. Eat Weight Disord. 2000 Sep; 5(3):175-82. PMID: 11082797.
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  425. Petridou E, Skalkidou A, Dessypris N, Moustaki M, Mantzoros C, Spanos E, Trichopoulos D. Endogenous risk factors for childhood leukemia in relation to the IGF system (Greece). The Childhood Haematologists-Oncologists Group. Cancer Causes Control. 2000 Sep; 11(8):765-71. PMID: 11065014.
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  426. Tsiodras S, Mantzoros C, Hammer S, Samore M. Effects of protease inhibitors on hyperglycemia, hyperlipidemia, and lipodystrophy: a 5-year cohort study. Arch Intern Med. 2000 Jul 10; 160(13):2050-6. PMID: 10888979.
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  427. Stuver SO, Kuper H, Tzonou A, Lagiou P, Spanos E, Hsieh CC, Mantzoros C, Trichopoulos D. Insulin-like growth factor 1 in hepatocellular carcinoma and metastatic liver cancer in men. Int J Cancer. 2000 Jul 01; 87(1):118-21. PMID: 10861461.
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  428. Mantzoros CS, Cramer DW, Liberman RF, Barbieri RL. Predictive value of serum and follicular fluid leptin concentrations during assisted reproductive cycles in normal women and in women with the polycystic ovarian syndrome. Hum Reprod. 2000 Mar; 15(3):539-44. PMID: 10686193.
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  429. Shaneyfelt T, Husein R, Bubley G, Mantzoros CS. Hormonal predictors of prostate cancer: a meta-analysis. J Clin Oncol. 2000 Feb; 18(4):847-53. PMID: 10673527.
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  430. Mantzoros CS. Role of leptin in reproduction. Ann N Y Acad Sci. 2000; 900:174-83. PMID: 10818404.
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  431. Linos A, Kaklamani VG, Kaklamani E, Koumantaki Y, Giziaki E, Papazoglou S, Mantzoros CS. Dietary factors in relation to rheumatoid arthritis: a role for olive oil and cooked vegetables? Am J Clin Nutr. 1999 Dec; 70(6):1077-82. PMID: 10584053.
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  432. Cittadini A, Mantzoros CS, Hampton TG, Travers KE, Katz SE, Morgan JP, Flier JS, Douglas PS. Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. Circulation. 1999 Nov 23; 100(21):2177-83. PMID: 10571977.
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  433. Kaklamani VG, Linos A, Kaklamani E, Markaki I, Koumantaki Y, Mantzoros CS. Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults. J Clin Oncol. 1999 Oct; 17(10):3291-8. PMID: 10506632.
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  434. Manousos O, Souglakos J, Bosetti C, Tzonou A, Chatzidakis V, Trichopoulos D, Adami HO, Mantzoros C. IGF-I and IGF-II in relation to colorectal cancer. Int J Cancer. 1999 Sep 24; 83(1):15-7. PMID: 10449601.
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  435. Mantzoros CS. Leptin in renal failure. J Ren Nutr. 1999 Jul; 9(3):122-5. PMID: 10431029.
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  436. Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med. 1999 Apr 20; 130(8):671-80. PMID: 10215564.
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  437. Kaklamani VG, Linos A, Kaklamani E, Markaki I, Mantzoros C. Age, sex, and smoking are predictors of circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3. J Clin Oncol. 1999 Mar; 17(3):813-7. PMID: 10071271.
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  438. Hsieh CC, Thanos A, Mitropoulos D, Deliveliotis C, Mantzoros CS, Trichopoulos D. Risk factors for prostate cancer: a case-control study in Greece. Int J Cancer. 1999 Mar 01; 80(5):699-703. PMID: 10048970.
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  439. Mantzoros CS, Bolhke K, Moschos S, Cramer DW. Leptin in relation to carcinoma in situ of the breast: a study of pre-menopausal cases and controls. Int J Cancer. 1999 Feb 09; 80(4):523-6. PMID: 9935151.
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  440. Petridou E, Dessypris N, Spanos E, Mantzoros C, Skalkidou A, Kalmanti M, Koliouskas D, Kosmidis H, Panagiotou JP, Piperopoulou F, Tzortzatou F, Trichopoulos D. Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia. Int J Cancer. 1999 Feb 09; 80(4):494-6. PMID: 9935146.
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  441. Varvarigou A, Mantzoros CS, Beratis NG. Cord blood leptin concentrations in relation to intrauterine growth. Clin Endocrinol (Oxf). 1999 Feb; 50(2):177-83. PMID: 10396359.
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  442. Signorello LB, Wuu J, Hsieh Cc, Tzonou A, Trichopoulos D, Mantzoros CS. Hormones and hair patterning in men: a role for insulin-like growth factor 1? J Am Acad Dermatol. 1999 Feb; 40(2 Pt 1):200-3. PMID: 10025745.
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  443. Acromite MT, Mantzoros CS, Leach RE, Hurwitz J, Dorey LG. Androgens in preeclampsia. Am J Obstet Gynecol. 1999 Jan; 180(1 Pt 1):60-3. PMID: 9914579.
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  444. Lagiou P, Signorello LB, Mantzoros CS, Trichopoulos D, Hsieh CC, Trichopoulou A. Hormonal, lifestyle, and dietary factors in relation to leptin among elderly men. Ann Nutr Metab. 1999; 43(1):23-9. PMID: 10364627.
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  445. Mantzoros CS. Leptin and the hypothalamus: neuroendocrine regulation of food intake. Mol Psychiatry. 1999 Jan; 4(1):8-12, 6-7. PMID: 10089000.
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  446. Mantzoros CS, Moschos SJ. Leptin: in search of role(s) in human physiology and pathophysiology. Clin Endocrinol (Oxf). 1998 Nov; 49(5):551-67. PMID: 10197068.
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  447. Audi L, Mantzoros CS, Vidal-Puig A, Vargas D, Gussinye M, Carrascosa A. Leptin in relation to resumption of menses in women with anorexia nervosa. Mol Psychiatry. 1998 Nov; 3(6):544-7. PMID: 9857982.
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  448. Licinio J, Negrão AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Negro PP, Mulla A, Veldhuis JD, Cearnal L, Flier JS, Gold PW. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab. 1998 Nov; 83(11):4140-7. PMID: 9814504.
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  449. Hsieh CC, Signorello LB, Lipworth L, Lagiou P, Mantzoros CS, Trichopoulos D. Predictors of sex hormone levels among the elderly: a study in Greece. J Clin Epidemiol. 1998 Oct; 51(10):837-41. PMID: 9762876.
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  450. Bohlke K, Cramer DW, Trichopoulos D, Mantzoros CS. Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast. Epidemiology. 1998 Sep; 9(5):570-3. PMID: 9730040.
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  451. Tritos NA, Mantzoros CS. Clinical review 97: Syndromes of severe insulin resistance. J Clin Endocrinol Metab. 1998 Sep; 83(9):3025-30. PMID: 9745395.
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  452. Roemmich JN, Clark PA, Berr SS, Mai V, Mantzoros CS, Flier JS, Weltman A, Rogol AD. Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am J Physiol. 1998 Sep; 275(3 Pt 1):E543-51. PMID: 9725824.
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  453. Tritos NA, Mantzoros CS. Recombinant human growth hormone: old and novel uses. Am J Med. 1998 Jul; 105(1):44-57. PMID: 9688021.
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  454. Wolk A, Mantzoros CS, Andersson SO, Bergström R, Signorello LB, Lagiou P, Adami HO, Trichopoulos D. Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. J Natl Cancer Inst. 1998 Jun 17; 90(12):911-5. PMID: 9637140.
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  455. Mantzoros CS, Prasad AS, Beck FW, Grabowski S, Kaplan J, Adair C, Brewer GJ. Zinc may regulate serum leptin concentrations in humans. J Am Coll Nutr. 1998 Jun; 17(3):270-5. PMID: 9627914.
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  456. Mantzoros CS, Liolios AD, Tritos NA, Kaklamani VG, Doulgerakis DE, Griveas I, Moses AC, Flier JS. Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men. Obes Res. 1998 May; 6(3):179-86. PMID: 9618121.
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  457. Lagiou P, Signorello LB, Trichopoulos D, Tzonou A, Trichopoulou A, Mantzoros CS. Leptin in relation to prostate cancer and benign prostatic hyperplasia. Int J Cancer. 1998 Mar 30; 76(1):25-8. PMID: 9533757.
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  458. Licinio J, Negrão AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, Mulla A, Cearnal L, Veldhuis JD, Flier JS, McCann SM, Gold PW. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proc Natl Acad Sci U S A. 1998 Mar 03; 95(5):2541-6. PMID: 9482922; PMCID: PMC19406.
  459. Mantzoros CS, Frederich RC, Qu D, Lowell BB, Maratos-Flier E, Flier JS. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes. 1998 Feb; 47(2):230-8. PMID: 9519718.
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  460. Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia. 1997 Dec; 40(12):1371-9. PMID: 9447943.
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  461. Georgiadis E, Papapostolou C, Korakis T, Evagelopoulou K, Mantzoros C, Batrinos M. The influence of smoking habits on thyroid gland volume: an ultrasonic approach. J R Soc Health. 1997 Dec; 117(6):355-8. PMID: 9519672.
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  462. Lagiou P, Mantzoros CS, Tzonou A, Signorello LB, Lipworth L, Trichopoulos D. Serum steroids in relation to benign prostatic hyperplasia. Oncology. 1997 Nov-Dec; 54(6):497-501. PMID: 9394847.
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  463. Mantzoros CS, Moschos S, Avramopoulos I, Kaklamani V, Liolios A, Doulgerakis DE, Griveas I, Katsilambros N, Flier JS. Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans. J Clin Endocrinol Metab. 1997 Oct; 82(10):3408-13. PMID: 9329377.
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  464. Mantzoros CS. Obesity, eating disorders and restrained eating: is leptin the missing link? Mol Psychiatry. 1997 Sep; 2(5):377-80. PMID: 9322227.
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  465. Mantzoros CS, Varvarigou A, Kaklamani VG, Beratis NG, Flier JS. Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns. J Clin Endocrinol Metab. 1997 Sep; 82(9):2856-61. PMID: 9284710.
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  466. Signorello LB, Tzonou A, Mantzoros CS, Lipworth L, Lagiou P, Hsieh C, Stampfer M, Trichopoulos D. Serum steroids in relation to prostate cancer risk in a case-control study (Greece). Cancer Causes Control. 1997 Jul; 8(4):632-6. PMID: 9242480.
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  467. Mantzoros C, Flier JS, Lesem MD, Brewerton TD, Jimerson DC. Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain. J Clin Endocrinol Metab. 1997 Jun; 82(6):1845-51. PMID: 9177394.
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  468. Mantzoros CS, Dunaif A, Flier JS. Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1997 Jun; 82(6):1687-91. PMID: 9177364.
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  469. Licinio J, Mantzoros C, Negrão AB, Cizza G, Wong ML, Bongiorno PB, Chrousos GP, Karp B, Allen C, Flier JS, Gold PW. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med. 1997 May; 3(5):575-9. PMID: 9142131.
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  470. Mantzoros CS, Flier JS, Rogol AD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab. 1997 Apr; 82(4):1066-70. PMID: 9100574.
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  471. Mantzoros CS, Suva LJ, Moses AC, Spark R. Intractable hypercalcaemia due to parathyroid hormone-related peptide secretion by a carcinoid tumour. Clin Endocrinol (Oxf). 1997 Mar; 46(3):373-5. PMID: 9156050.
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  472. Mantzoros CS, Rosen HN, Greenspan SL, Flier JS, Moses AC. Short-term hyperthyroidism has no effect on leptin levels in man. J Clin Endocrinol Metab. 1997 Feb; 82(2):497-9. PMID: 9024243.
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  473. Mantzoros CS, Tzonou A, Signorello LB, Stampfer M, Trichopoulos D, Adami HO. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. Br J Cancer. 1997; 76(9):1115-8. PMID: 9365156; PMCID: PMC2228109.
  474. Georgiadis E, Mantzoros CS, Evagelopoulou C, Spentzos D. Adult height and menarcheal age of young women in Greece. Ann Hum Biol. 1997 Jan-Feb; 24(1):55-9. PMID: 9022906.
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  475. Mantzoros CS, Moses AC. Whither recombinant human growth hormone? Ann Intern Med. 1996 Dec 01; 125(11):932-4. PMID: 8967675.
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  476. Houseknecht KL, Mantzoros CS, Kuliawat R, Hadro E, Flier JS, Kahn BB. Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes. 1996 Nov; 45(11):1638-43. PMID: 8866573.
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  477. Mantzoros CS, Georgiadis EI, Evangelopoulou K, Katsilambros N. Dehydroepiandrosterone sulfate and testosterone are independently associated with body fat distribution in premenopausal women. Epidemiology. 1996 Sep; 7(5):513-6. PMID: 8862983.
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  478. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature. 1996 Jul 18; 382(6588):250-2. PMID: 8717038.
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  479. Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos-Flier E, Flier JS. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes. 1996 Jul; 45(7):909-14. PMID: 8666142.
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  480. Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition. 1996 May; 12(5):344-8. PMID: 8875519.
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  481. Lipworth L, Adami HO, Trichopoulos D, Carlström K, Mantzoros C. Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the etiology of postmenopausal breast cancer. Epidemiology. 1996 Jan; 7(1):96-100. PMID: 8664410.
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  482. Mantzoros CS, Evagelopoulou K, Georgiadis EI, Katsilambros N. Conicity index as a predictor of blood pressure levels, insulin and triglyceride concentrations of healthy premenopausal women. Horm Metab Res. 1996 Jan; 28(1):32-4. PMID: 8820992.
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  483. Mantzoros CS, Evagelopoulou K, Moses AC. Outcome of percutaneous transluminal coronary angioplasty in patients with subclinical hypothyroidism. Thyroid. 1995 Oct; 5(5):383-7. PMID: 8563477.
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  484. Mantzoros CS, Moses AC. Isolated combined growth hormone and gonadotrophin deficiency due to hypothalamic dysfunction, associated with insulin resistance. Clin Endocrinol (Oxf). 1995 Aug; 43(2):231-3. PMID: 7554320.
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  485. Mantzoros CS, Georgiadis EI. Body mass and physical activity are important predictors of serum androgen concentrations in young healthy men. Epidemiology. 1995 Jul; 6(4):432-5. PMID: 7548356.
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  486. Hamann A, Mantzoros C, Vidal-Puig A, Flier JS. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Commun. 1995 Jun 26; 211(3):833-9. PMID: 7598712.
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  487. Mantzoros CS, Georgiadis EI, Young R, Evagelopoulou C, Khoury S, Katsilambros N, Sowers JR. Relative androgenicity, blood pressure levels, and cardiovascular risk factors in young healthy women. Am J Hypertens. 1995 Jun; 8(6):606-14. PMID: 7662245.
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  488. Mantzoros CS, Lawrence WD, Levy J. Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor. J Reprod Med. 1995 Jun; 40(6):491-4. PMID: 7650669.
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  489. Mantzoros CS, Georgiadis EI, Trichopoulos D. Contribution of dihydrotestosterone to male sexual behaviour. BMJ. 1995 May 20; 310(6990):1289-91. PMID: 7773040; PMCID: PMC2549675.
  490. Papapostolou C, Mantzoros CS, Evagelopoulou C, Moses AC, Kleefield J. Imaging of the sella in the syndrome of inappropriate secretion of antidiuretic hormone. J Intern Med. 1995 Feb; 237(2):181-5. PMID: 7852921.
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  491. Mantzoros CS, Flier JS. Insulin resistance: the clinical spectrum. Adv Endocrinol Metab. 1995; 6:193-232. PMID: 7671097.
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  492. Ravi J, Mantzoros CS, Prabhu AS, Ram JL, Sowers JR. In vitro relaxation of phenylephrine- and angiotensin II-contracted aortic rings by beta-estradiol. Am J Hypertens. 1994 Dec; 7(12):1065-9. PMID: 7702800.
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  493. Mantzoros CS, Prabhu AS, Sowers JR. Paralytic ileus as a result of diltiazem treatment. J Intern Med. 1994 Jun; 235(6):613-4. PMID: 8207368.
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  494. Mantzoros CS, Brown PD, Dembry L. Extraosseous epidural tuberculoma: case report and review. Clin Infect Dis. 1993 Dec; 17(6):1032-6. PMID: 8110926.
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  495. Mantzoros CS, Ravi J. Treatment of myxedema-associated cardiogenic shock. Ann Intern Med. 1993 Jul 15; 119(2):168; author reply 169. PMID: 8512169.
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  496. Mantzoros C, Bazzi M, Hadidi MF. Skin lesion in an acutely ill man with HIV. Hosp Pract (Off Ed). 1993 Apr 15; 28(4):100. PMID: 8463358.
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