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Olga V. Demler, Ph.D.

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Overview
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As a biostatistician working at the Division of Preventive Medicine at Brigham and Women’s Hospital, my research interests are three-fold:
1) conducting biomarker discovery studies using high throughput metabolomics and other -omics data;
2) analysis of Electronic Health Records data;
3) methodological statistical research on building valid risk prediction models.
My clinical research focuses on the mechanistic pathways of cardiovascular disease development and progression.

The following publications highlight some of my research activities:

1. Kessler RC, Bauer M, Bishop T, Demler O, Dobscha S, Gildea S, Goulet J, Karras E, Kreyenbuhl J, Landes S, Liu H. Using administrative data to predict suicide after psychiatric hospitalization. Frontiers in Psychiatry. 2020;11:390.

2. Sels D, Dashti H, Mora S, Demler O, Demler E. Quantum approximate Bayesian computation for NMR model inference. arXiv preprint arXiv:1910.14221. 2019 Oct 31.

3. Antonelli J, Claggett BL, Henglin M, Kim A, Ovsak G, Kim N, Deng K, Rao K, Tyagi O, Watrous JD, Lagerborg KA, Hushcha PV, Demler OV, Mora S, Niiranen TJ, Pereira AC, Jain M, Cheng S. Statistical Workflow for Feature Selection in Human Metabolomics Data. Metabolites. 2019 Jul 12; 9(7). PMID: 31336989.

4. Demler OV, Pencina MJ, Cook NR, D'Agostino RB. Asymptotic distribution of AUC, NRIs, and IDI based on theory of U-statistics. Stat Med. 2017 Sep 20; 36(21):3334-3360. PMID: 28627112.

5. Demler OV, Paynter NP, Cook NR. Tests of calibration and goodness-of-fit in the survival setting. Stat Med. 2015 May 10; 34(10):1659-80. PMID: 25684707.

6. Demler OV, Pencina MJ, D'Agostino RB. Impact of correlation on predictive ability of biomarkers. Stat Med. 2013 Oct 30; 32(24):4196-210. PMID: 23640729.

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. 17IGMV33860009 (Olga V Demler) Jan 1, 2020 - Mar 31, 2021
    American Hearth Association
    Flexible Framework for Cardiovascular Risk Prediction in a Clinical Setting
    Role Description: The goal of this grant is to evaluate the improvement in prediction using a Flexible Framework. This framework can handle limited information or additional risk factors by combining multiple risk models including both externally derived and validated risk scores as well as models using historic EHR data.
    Role: Principal Investigator
  2. K01HL135342 (DEMLER, OLGA) Dec 15, 2016 - Nov 30, 2021
    NIH
    CHD Risk and Metabolomic Profiles of Discordant Lipids
    Role Description: Accurate assessment of cardiovascular risk in the clinical setting is important for appropriate management and counseling of patients. Current US guidelines focus on a single risk score, which does not facilitate inclusion of additional known risk factors or allow for assessment of risk with more limited information, both of which occur in clinical practice. With the growing availability of electronic health record (EHR) data, methods for using all available information to succinctly identify the best course of care are increasingly important. This grant will evaluate the improvement in prediction using a Flexible Framework. This framework can handle limited information or additional risk factors by combining multiple risk models including both externally derived and validated risk scores as well as models using historic EHR data. The results of this project will form the basis for subsequent development of a cloud-based tool for use across software platforms.
    Role: Principal Investigator

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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kessler RC, Bauer MS, Bishop TM, Bossarte RM, Castro VM, Demler OV, Gildea SM, Goulet JL, King AJ, Kennedy CJ, Landes SJ, Liu H, Luedtke A, Mair P, Marx BP, Nock MK, Petukhova MV, Pigeon WR, Sampson NA, Smoller JW, Miller A, Haas G, Benware J, Bradley J, Owen RR, House S, Urosevic S, Weinstock LM. Evaluation of a Model to Target High-risk Psychiatric Inpatients for an Intensive Postdischarge Suicide Prevention Intervention. JAMA Psychiatry. 2023 Mar 01; 80(3):230-240. PMID: 36652267; PMCID: PMC9857842.
    Citations:    Fields:    Translation:Humans
  2. Birukov A, Plavša B, Eichelmann F, Kuxhaus O, Hoshi RA, Rudman N, Štambuk T, Trbojevic-Akmacic I, Schiborn C, Morze J, Mihelcic M, Cindric A, Liu Y, Demler O, Perola M, Mora S, Schulze MB, Lauc G, Wittenbecher C. Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease. Diabetes Care. 2022 11 01; 45(11):2729-2736. PMID: 36174116; PMCID: PMC9679264.
    Citations: 1     Fields:    Translation:HumansCells
  3. Hoshi RA, Liu Y, Luttmann-Gibson H, Tiwari S, Giulianini F, Andres AM, Watrous JD, Cook NR, Costenbader KH, Okereke OI, Ridker PM, Manson JE, Lee IM, Vinayagamoorthy M, Cheng S, Copeland T, Jain M, Chasman DI, Demler OV, Mora S. Association of Physical Activity With Bioactive Lipids and Cardiovascular Events. Circ Res. 2022 08 05; 131(4):e84-e99. PMID: 35862024; PMCID: PMC9357171.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  4. Henglin M, Claggett BL, Antonelli J, Alotaibi M, Magalang GA, Watrous JD, Lagerborg KA, Ovsak G, Musso G, Demler OV, Vasan RS, Larson MG, Jain M, Cheng S. Quantitative Comparison of Statistical Methods for Analyzing Human Metabolomics Data. Metabolites. 2022 Jun 04; 12(6). PMID: 35736452; PMCID: PMC9227835.
    Citations: 2     
  5. Dugani SB, Moorthy MV, Li C, Demler OV, Alsheikh-Ali AA, Ridker PM, Glynn RJ, Mora S. Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women. JAMA Cardiol. 2021 04 01; 6(4):437-447. PMID: 33471027; PMCID: PMC7818181.
    Citations: 30     Fields:    Translation:Humans
  6. Dashti H, Roche EC, Bates DW, Mora S, Demler O. SARS2 simplified scores to estimate risk of hospitalization and death among patients with COVID-19. Sci Rep. 2021 03 02; 11(1):4945. PMID: 33654180; PMCID: PMC7925678.
    Citations: 10     Fields:    Translation:HumansCells
  7. Balasubramanian R, Demler O, Guasch-Ferré M, Paynter NP, Sheehan R, Liu S, Manson JE, Salas-Salvadó J, Martínez-Gonzalez MÁ, Hu FB, Clish C, Rexrode KM. Metabolomic Effects of Hormone Therapy and Associations With Coronary Heart Disease Among Postmenopausal Women. Circ Genom Precis Med. 2020 12; 13(6):e002977. PMID: 33141616; PMCID: PMC8824616.
    Citations: 4     Fields:    Translation:HumansAnimals
  8. Ahmad S, Demler OV, Sun Q, Moorthy MV, Li C, Lee IM, Ridker PM, Manson JE, Hu FB, Fall T, Chasman DI, Cheng S, Pradhan A, Mora S. Association of the Mediterranean Diet With Onset of Diabetes in the Women's Health Study. JAMA Netw Open. 2020 11 02; 3(11):e2025466. PMID: 33211107.
    Citations: 14     Fields:    Translation:Humans
  9. Demler OV, Liu Y, Luttmann-Gibson H, Watrous JD, Lagerborg KA, Dashti H, Giulianini F, Heath M, Camargo CA, Harris WS, Wohlgemuth JG, Andres AM, Tivari S, Long T, Najhawan M, Dao K, Prentice JG, Larsen JA, Okereke OI, Costenbader KH, Buring JE, Manson JE, Cheng S, Jain M, Mora S. One-Year Effects of Omega-3 Treatment on Fatty Acids, Oxylipins, and Related Bioactive Lipids and Their Associations with Clinical Lipid and Inflammatory Biomarkers: Findings from a Substudy of the Vitamin D and Omega-3 Trial (VITAL). Metabolites. 2020 Oct 27; 10(11). PMID: 33120862; PMCID: PMC7693376.
    Citations: 5     
  10. Dashti H, Roche EC, Bates DW, Mora S, Demler O. SARS2 simplified scores to estimate risk of hospitalization and death among patients with COVID-19. medRxiv. 2020 Sep 13. PMID: 32935112.
    Citations: 1     
  11. Ajala ON, Demler OV, Liu Y, Farukhi Z, Adelman SJ, Collins HL, Ridker PM, Rader DJ, Glynn RJ, Mora S. Anti-Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial. J Am Heart Assoc. 2020 09; 9(17):e016507. PMID: 32799709; PMCID: PMC7660788.
    Citations: 11     Fields:    Translation:Humans
  12. Dashti HT, Bates D, Fiskio JM, Roche EC, Mora S, Demler O. Clinical Characteristics and Severity of COVID-19 Disease in Patients from Boston Area Hospitals. medRxiv. 2020 Aug 04. PMID: 32793930.
    Citations:    
  13. Sels D, Dashti H, Mora S, Demler O, Demler E. Quantum approximate Bayesian computation for NMR model inference. Nat Mach Intell. 2020 Jul; 2(7):396-402. PMID: 33163858.
    Citations: 3     
  14. Dashti H, Westler WM, Wedell JR, Demler OV, Eghbalnia HR, Markley JL, Mora S. Probabilistic identification of saccharide moieties in biomolecules and their protein complexes. Sci Data. 2020 07 03; 7(1):210. PMID: 32620933; PMCID: PMC7335193.
    Citations: 4     Fields:    
  15. Kessler RC, Bauer MS, Bishop TM, Demler OV, Dobscha SK, Gildea SM, Goulet JL, Karras E, Kreyenbuhl J, Landes SJ, Liu H, Luedtke AR, Mair P, McAuliffe WHB, Nock M, Petukhova M, Pigeon WR, Sampson NA, Smoller JW, Weinstock LM, Bossarte RM. Using Administrative Data to Predict Suicide After Psychiatric Hospitalization in the Veterans Health Administration System. Front Psychiatry. 2020; 11:390. PMID: 32435212; PMCID: PMC7219514.
    Citations: 13     
  16. Chasman DI, Giulianini F, Demler OV, Udler MS. Pleiotropy-Based Decomposition of Genetic Risk Scores: Association and Interaction Analysis for Type 2 Diabetes and CAD. Am J Hum Genet. 2020 05 07; 106(5):646-658. PMID: 32302534.
    Citations: 5     Fields:    Translation:Humans
  17. Farukhi ZM, Demler OV, Caulfield MP, Kulkarni K, Wohlgemuth J, Cobble M, Luttmann-Gibson H, Li C, Nelson JR, Cook NR, Buring JE, Krauss RM, Manson JE, Mora S. Comparison of nonfasting and fasting lipoprotein subfractions and size in 15,397 apparently healthy individuals: An analysis from the VITamin D and OmegA-3 TriaL. J Clin Lipidol. 2020 Mar - Apr; 14(2):241-251. PMID: 32205068.
    Citations: 8     Fields:    Translation:Humans
  18. Luttmann-Gibson H, Mora S, Camargo CA, Cook NR, Demler OV, Ghoshal A, Wohlgemuth J, Kulkarni K, Larsen J, Prentice J, Cobble M, Bubes V, Li C, Friedenberg G, Lee IM, Buring JE, Manson JE. Serum 25-hydroxyvitamin D in the VITamin D and OmegA-3 TriaL (VITAL): Clinical and demographic characteristics associated with baseline and change with randomized vitamin D treatment. Contemp Clin Trials. 2019 12; 87:105854. PMID: 31669447; PMCID: PMC6875603.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  19. Antonelli J, Claggett BL, Henglin M, Kim A, Ovsak G, Kim N, Deng K, Rao K, Tyagi O, Watrous JD, Lagerborg KA, Hushcha PV, Demler OV, Mora S, Niiranen TJ, Pereira AC, Jain M, Cheng S. Statistical Workflow for Feature Selection in Human Metabolomics Data. Metabolites. 2019 Jul 12; 9(7). PMID: 31336989; PMCID: PMC6680705.
    Citations: 19     
  20. Henglin M, Niiranen T, Watrous JD, Lagerborg KA, Antonelli J, Claggett BL, Demosthenes EJ, von Jeinsen B, Demler O, Vasan RS, Larson MG, Jain M, Cheng S. A Single Visualization Technique for Displaying Multiple Metabolite-Phenotype Associations. Metabolites. 2019 Jul 02; 9(7). PMID: 31269707; PMCID: PMC6680673.
    Citations: 11     
  21. Enserro DM, Demler OV, Pencina MJ, D'Agostino RB. Measures for evaluation of prognostic improvement under multivariate normality for nested and nonnested models. Stat Med. 2019 09 10; 38(20):3817-3831. PMID: 31211443.
    Citations: 1     Fields:    Translation:Humans
  22. Ahmad S, Moorthy MV, Demler OV, Hu FB, Ridker PM, Chasman DI, Mora S. Assessment of Risk Factors and Biomarkers Associated With Risk of Cardiovascular Disease Among Women Consuming a Mediterranean Diet. JAMA Netw Open. 2018 12 07; 1(8):e185708. PMID: 30646282; PMCID: PMC6324327.
    Citations: 27     Fields:    Translation:Humans
  23. Demler OV, Paynter NP, Cook NR. Reclassification calibration test for censored survival data: performance and comparison to goodness-of-fit criteria. Diagn Progn Res. 2018; 2. PMID: 30984876; PMCID: PMC6456068.
    Citations: 3     
  24. Tobias DK, Lawler PR, Harada PH, Demler OV, Ridker PM, Manson JE, Cheng S, Mora S. Circulating Branched-Chain Amino Acids and Incident Cardiovascular Disease in a Prospective Cohort of US Women. Circ Genom Precis Med. 2018 04; 11(4):e002157. PMID: 29572205.
    Citations: 65     Fields:    Translation:HumansCells
  25. Cook NR, Demler OV, Paynter NP. Clinical risk reclassification at 10 years. Stat Med. 2017 Dec 10; 36(28):4498-4502. PMID: 29156504.
    Citations: 4     Fields:    Translation:Humans
  26. Harada PHN, Demler OV, Dugani SB, Akinkuolie AO, Moorthy MV, Ridker PM, Cook NR, Pradhan AD, Mora S. Lipoprotein insulin resistance score and risk of incident diabetes during extended follow-up of 20 years: The Women's Health Study. J Clin Lipidol. 2017 Sep - Oct; 11(5):1257-1267.e2. PMID: 28733174.
    Citations: 23     Fields:    Translation:Humans
  27. Demler OV, Pencina MJ, Cook NR, D'Agostino RB. Asymptotic distribution of ?AUC, NRIs, and IDI based on theory of U-statistics. Stat Med. 2017 Sep 20; 36(21):3334-3360. PMID: 28627112.
    Citations: 12     Fields:    Translation:Humans
  28. Khera AV, Demler OV, Adelman SJ, Collins HL, Glynn RJ, Ridker PM, Rader DJ, Mora S. Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin). Circulation. 2017 Jun 20; 135(25):2494-2504. PMID: 28450350; PMCID: PMC5490983.
    Citations: 92     Fields:    Translation:Humans
  29. White KT, Moorthy MV, Akinkuolie AO, Demler O, Ridker PM, Cook NR, Mora S. Identifying an Optimal Cutpoint for the Diagnosis of Hypertriglyceridemia in the Nonfasting State. Clin Chem. 2015 Sep; 61(9):1156-63. PMID: 26071491; PMCID: PMC4554926.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  30. Demler OV, Paynter NP, Cook NR. Tests of calibration and goodness-of-fit in the survival setting. Stat Med. 2015 May 10; 34(10):1659-80. PMID: 25684707.
    Citations: 126     Fields:    Translation:Humans
  31. Demler OV, Pencina MJ, D'Agostino RB. Impact of correlation on predictive ability of biomarkers. Stat Med. 2013 Oct 30; 32(24):4196-210. PMID: 23640729.
    Citations: 7     Fields:    Translation:Humans
  32. Pencina MJ, D'Agostino RB, Demler OV, Janssens AC, Greenland P. Pencina et al. respond to "The incremental value of new markers" and "Clinically relevant measures? A note of caution". Am J Epidemiol. 2012 Sep 15; 176(6):492-4. PMID: 22875757.
    Citations: 5     Fields:    Translation:Humans
  33. Demler OV, Pencina MJ, D'Agostino RB. Misuse of DeLong test to compare AUCs for nested models. Stat Med. 2012 Oct 15; 31(23):2577-87. PMID: 22415937.
    Citations: 88     Fields:    Translation:Humans
  34. Pencina MJ, D'Agostino RB, Demler OV. Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models. Stat Med. 2012 Jan 30; 31(2):101-13. PMID: 22147389.
    Citations: 117     Fields:    Translation:Humans
  35. Demler OV, Pencina MJ, D'Agostino RB. Equivalence of improvement in area under ROC curve and linear discriminant analysis coefficient under assumption of normality. Stat Med. 2011 May 30; 30(12):1410-8. PMID: 21337594.
    Citations: 18     Fields:    Translation:Humans
  36. Wang PS, Demler O, Olfson M, Pincus HA, Wells KB, Kessler RC. Changing profiles of service sectors used for mental health care in the United States. Am J Psychiatry. 2006 Jul; 163(7):1187-98. PMID: 16816223; PMCID: PMC1941780.
    Citations: 99     Fields:    Translation:Humans
  37. Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, Spencer T, Ustun TB, Walters EE, Zaslavsky AM. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006 Apr; 163(4):716-23. PMID: 16585449; PMCID: PMC2859678.
    Citations: 899     Fields:    Translation:Humans
  38. Kessler RC, Birnbaum H, Demler O, Falloon IR, Gagnon E, Guyer M, Howes MJ, Kendler KS, Shi L, Walters E, Wu EQ. The prevalence and correlates of nonaffective psychosis in the National Comorbidity Survey Replication (NCS-R). Biol Psychiatry. 2005 Oct 15; 58(8):668-76. PMID: 16023620; PMCID: PMC2847859.
    Citations: 127     Fields:    Translation:HumansPHPublic Health
  39. Kessler RC, Demler O, Frank RG, Olfson M, Pincus HA, Walters EE, Wang P, Wells KB, Zaslavsky AM. Prevalence and treatment of mental disorders, 1990 to 2003. N Engl J Med. 2005 Jun 16; 352(24):2515-23. PMID: 15958807; PMCID: PMC2847367.
    Citations: 541     Fields:    Translation:Humans
  40. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005 Jun; 62(6):593-602. PMID: 15939837.
    Citations: 5363     Fields:    Translation:Humans
  41. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005 Jun; 62(6):617-27. PMID: 15939839; PMCID: PMC2847357.
    Citations: 3348     Fields:    Translation:Humans
  42. Kessler RC, Adler L, Ames M, Demler O, Faraone S, Hiripi E, Howes MJ, Jin R, Secnik K, Spencer T, Ustun TB, Walters EE. The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. Psychol Med. 2005 Feb; 35(2):245-56. PMID: 15841682.
    Citations: 742     Fields:    Translation:HumansPHPublic Health
  43. Kessler RC, Abelson J, Demler O, Escobar JI, Gibbon M, Guyer ME, Howes MJ, Jin R, Vega WA, Walters EE, Wang P, Zaslavsky A, Zheng H. Clinical calibration of DSM-IV diagnoses in the World Mental Health (WMH) version of the World Health Organization (WHO) Composite International Diagnostic Interview (WMHCIDI). Int J Methods Psychiatr Res. 2004; 13(2):122-39. PMID: 15297907; PMCID: PMC6878301.
    Citations: 208     Fields:    Translation:Humans
  44. Kessler RC, Berglund P, Chiu WT, Demler O, Heeringa S, Hiripi E, Jin R, Pennell BE, Walters EE, Zaslavsky A, Zheng H. The US National Comorbidity Survey Replication (NCS-R): design and field procedures. Int J Methods Psychiatr Res. 2004; 13(2):69-92. PMID: 15297905; PMCID: PMC6878537.
    Citations: 322     Fields:    Translation:Humans
  45. Kessler RC, Ormel J, Demler O, Stang PE. Comorbid mental disorders account for the role impairment of commonly occurring chronic physical disorders: results from the National Comorbidity Survey. J Occup Environ Med. 2003 Dec; 45(12):1257-66. PMID: 14665811.
    Citations: 90     Fields:    Translation:Humans
  46. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003 Jun 18; 289(23):3095-105. PMID: 12813115.
    Citations: 2518     Fields:    Translation:HumansPHPublic Health
  47. Kessler RC, Andrade LH, Bijl RV, Offord DR, Demler OV, Stein DJ. The effects of co-morbidity on the onset and persistence of generalized anxiety disorder in the ICPE surveys. International Consortium in Psychiatric Epidemiology. Psychol Med. 2002 Oct; 32(7):1213-25. PMID: 12420891.
    Citations: 13     Fields:    Translation:Humans
  48. Wang PS, Demler O, Kessler RC. Adequacy of treatment for serious mental illness in the United States. Am J Public Health. 2002 Jan; 92(1):92-8. PMID: 11772769; PMCID: PMC1447396.
    Citations: 128     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.