Harvard Catalyst Profiles

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Federica Del Monte, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG057046 (WOLD, LOREN EUGENE) Jul 15, 2017 - Mar 31, 2022
    Mechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's Disease
    Role: Co-Principal Investigator
  2. R21HL110042 (DEL MONTE, FEDERICA) Aug 1, 2011 - Oct 30, 2013
    Identifying transcription factors that drive human cardiomyopathy
    Role: Co-Principal Investigator
  3. R01HL098468 (DEL MONTE, FEDERICA) Aug 1, 2010 - Apr 30, 2014
    Role of Presenilin in Idiopathic Dilated Cardiomyopathy
    Role: Principal Investigator
  4. R21HL102716 (DEL MONTE, FEDERICA) Apr 15, 2010 - Jun 30, 2012
    Mechanisms of misfolded protein toxicity in idiopathic Dilated Cardiomyopathy and
    Role: Principal Investigator
  5. K08HL069842 (DEL MONTE, FEDERICA) Sep 30, 2002 - Aug 31, 2007
    SERCA2a Abnormalities and Chaperones in Heart Failure
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 May 22; 11(493). PMID: 31118289.
  2. Luciani M, Del Monte F. The more we learn, the less we know: A novel cardiac mechanism of brain damage. J Mol Cell Cardiol. 2019 Mar; 128:158-159. PMID: 30703354.
    Citations:    Fields:    
  3. Tublin JM, Adelstein JM, Del Monte F, Combs CK, Wold LE. Getting to the Heart of Alzheimer Disease. Circ Res. 2019 Jan 04; 124(1):142-149. PMID: 30605407.
    Citations:    Fields:    
  4. Luciani M, Del Monte F. Insights from Second-Line Treatments for Idiopathic Dilated Cardiomyopathy. J Cardiovasc Dev Dis. 2017 Aug 23; 4(3). PMID: 29367542.
  5. Bernini F, Malferrari D, Pignataro M, Bortolotti CA, Di Rocco G, Lancellotti L, Brigatti MF, Kayed R, Borsari M, Del Monte F, Castellini E. Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity. Sci Rep. 2017 01 19; 7:40897. PMID: 28102308.
    Citations:    Fields:    
  6. Del Monte F, Ishikawa K, Hajjar RJ. Gene Transfer to Rodent Hearts In Vivo. Methods Mol Biol. 2017; 1521:195-204. PMID: 27910050.
    Citations: 2     Fields:    Translation:Animals
  7. Troncone L, Luciani M, Coggins M, Wilker EH, Ho CY, Codispoti KE, Frosch MP, Kayed R, Del Monte F. Aß Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart. J Am Coll Cardiol. 2016 Dec 06; 68(22):2395-2407. PMID: 27908343.
    Citations: 5     Fields:    Translation:Humans
  8. Bernini F, Malferrari D, Pignataro M, Bortolotti CA, Di Rocco G, Lancellotti L, Brigatti MF, Kayed R, Borsari M, Del Monte F, Castellini E. Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity. Sci Rep. 2016 10 24; 6:35865. PMID: 27775057.
    Citations:    Fields:    Translation:HumansCells
  9. Subramanian K, Gianni D, Balla C, Assenza GE, Joshi M, Semigran MJ, Macgillivray TE, Van Eyk JE, Agnetti G, Paolocci N, Bamburg JR, Agrawal PB, Del Monte F. Cofilin-2 phosphorylation and sequestration in myocardial aggregates: novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2015 Mar 31; 65(12):1199-1214. PMID: 25814227.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Del Monte F, Agnetti G. Protein post-translational modifications and misfolding: new concepts in heart failure. Proteomics Clin Appl. 2014 Aug; 8(7-8):534-42. PMID: 24946239.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Signore S, Sorrentino A, Ferreira-Martins J, Kannappan R, Shafaie M, Del Ben F, Isobe K, Arranto C, Wybieralska E, Webster A, Sanada F, Ogórek B, Zheng H, Liu X, del Monte F, D'Alessandro DA, Wunimenghe O, Michler RE, Hosoda T, Goichberg P, Leri A, Kajstura J, Anversa P, Rota M. Response to letter regarding article "Inositol 1,4,5-trisphosphate receptors and human left ventricular myocytes". Circulation. 2014 May 27; 129(21):e510-1. PMID: 24868002.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Lin H, Dolmatova EV, Morley MP, Lunetta KL, McManus DD, Magnani JW, Margulies KB, Hakonarson H, del Monte F, Benjamin EJ, Cappola TP, Ellinor PT. Gene expression and genetic variation in human atria. Heart Rhythm. 2014 Feb; 11(2):266-71. PMID: 24177373.
    Citations: 14     Fields:    Translation:HumansCells
  13. Graham EL, Balla C, Franchino H, Melman Y, del Monte F, Das S. Isolation, culture, and functional characterization of adult mouse cardiomyoctyes. J Vis Exp. 2013 Sep 24; (79):e50289. PMID: 24084584.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Guan J, Mishra S, Shi J, Plovie E, Qiu Y, Cao X, Gianni D, Jiang B, Del Monte F, Connors LH, Seldin DC, Lavatelli F, Rognoni P, Palladini G, Merlini G, Falk RH, Semigran MJ, Dec GW, Macrae CA, Liao R. Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. Basic Res Cardiol. 2013 Sep; 108(5):378. PMID: 23982491.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  15. Signore S, Sorrentino A, Ferreira-Martins J, Kannappan R, Shafaie M, Del Ben F, Isobe K, Arranto C, Wybieralska E, Webster A, Sanada F, Ogórek B, Zheng H, Liu X, Del Monte F, D'Alessandro DA, Wunimenghe O, Michler RE, Hosoda T, Goichberg P, Leri A, Kajstura J, Anversa P, Rota M. Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation. 2013 Sep 17; 128(12):1286-97. PMID: 23983250.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  16. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug; 123(8):3378-82. PMID: 23867623.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  17. Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P, Morissette MR, del Monte F, Begley MJ, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation. 2012 Oct 30; 126(18):2208-19. PMID: 23019294.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  18. Kajstura J, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y, Ferreira-Martins J, Signore S, Sanada F, Matsuda A, Kostyla J, Caballero MV, Fiorini C, D'Alessandro DA, Michler RE, del Monte F, Hosoda T, Perrella MA, Leri A, Buchholz BA, Loscalzo J, Anversa P. Cardiomyogenesis in the aging and failing human heart. Circulation. 2012 Oct 09; 126(15):1869-81. PMID: 22955965.
    Citations: 51     Fields:    Translation:HumansCells
  19. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature. 2012 May 09; 485(7398):333-8. PMID: 22596155.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  20. Goichberg P, Bai Y, D'Amario D, Ferreira-Martins J, Fiorini C, Zheng H, Signore S, del Monte F, Ottolenghi S, D'Alessandro DA, Michler RE, Hosoda T, Anversa P, Kajstura J, Rota M, Leri A. The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction. Circ Res. 2011 Apr 29; 108(9):1071-83. PMID: 21415392.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  21. Hosoda T, Zheng H, Cabral-da-Silva M, Sanada F, Ide-Iwata N, Ogórek B, Ferreira-Martins J, Arranto C, D'Amario D, del Monte F, Urbanek K, D'Alessandro DA, Michler RE, Anversa P, Rota M, Kajstura J, Leri A. Human cardiac stem cell differentiation is regulated by a mircrine mechanism. Circulation. 2011 Mar 29; 123(12):1287-96. PMID: 21403094.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  22. Cilenti L, Balakrishnan MP, Wang XL, Ambivero C, Sterlicchi M, del Monte F, Ma XL, Zervos AS. Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. J Mol Cell Cardiol. 2011 Apr; 50(4):652-61. PMID: 21195082.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  23. Kajstura J, Gurusamy N, Ogórek B, Goichberg P, Clavo-Rondon C, Hosoda T, D'Amario D, Bardelli S, Beltrami AP, Cesselli D, Bussani R, del Monte F, Quaini F, Rota M, Beltrami CA, Buchholz BA, Leri A, Anversa P. Myocyte turnover in the aging human heart. Circ Res. 2010 Nov 26; 107(11):1374-86. PMID: 21088285.
    Citations: 96     Fields:    Translation:HumansCells
  24. Peña JR, Szkudlarek AC, Warren CM, Heinrich LS, Gaffin RD, Jagatheesan G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2010 Dec; 49(6):993-1002. PMID: 20854827.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  25. Lubitz SA, Sinner MF, Lunetta KL, Makino S, Pfeufer A, Rahman R, Veltman CE, Barnard J, Bis JC, Danik SP, Sonni A, Shea MA, Del Monte F, Perz S, Müller M, Peters A, Greenberg SM, Furie KL, van Noord C, Boerwinkle E, Stricker BH, Witteman J, Smith JD, Chung MK, Heckbert SR, Benjamin EJ, Rosand J, Arking DE, Alonso A, Kääb S, Ellinor PT. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation. 2010 Sep 07; 122(10):976-84. PMID: 20733104.
    Citations: 54     Fields:    Translation:HumansCells
  26. Kajstura J, Urbanek K, Perl S, Hosoda T, Zheng H, Ogórek B, Ferreira-Martins J, Goichberg P, Rondon-Clavo C, Sanada F, D'Amario D, Rota M, Del Monte F, Orlic D, Tisdale J, Leri A, Anversa P. Cardiomyogenesis in the adult human heart. Circ Res. 2010 Jul 23; 107(2):305-15. PMID: 20522802.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  27. Karamanlidis G, Nascimben L, Couper GS, Shekar PS, del Monte F, Tian R. Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res. 2010 May 14; 106(9):1541-8. PMID: 20339121.
    Citations: 62     Fields:    Translation:HumansCells
  28. Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, del Monte F. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 2010 Mar 16; 121(10):1216-26. PMID: 20194882.
    Citations: 26     Fields:    Translation:Humans
  29. Shi J, Guan J, Jiang B, Brenner DA, Del Monte F, Ward JE, Connors LH, Sawyer DB, Semigran MJ, Macgillivray TE, Seldin DC, Falk R, Liao R. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4188-93. PMID: 20150510.
    Citations: 68     Fields:    Translation:HumansCells
  30. Tsuji T, Del Monte F, Yoshikawa Y, Abe T, Shimizu J, Nakajima-Takenaka C, Taniguchi S, Hajjar RJ, Takaki M. Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholamban. Am J Physiol Heart Circ Physiol. 2009 Feb; 296(2):H310-7. PMID: 19074672.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  31. Dally S, Monceau V, Corvazier E, Bredoux R, Raies A, Bobe R, del Monte F, Enouf J. Compartmentalized expression of three novel sarco/endoplasmic reticulum Ca2+ATPase 3 isoforms including the switch to ER stress, SERCA3f, in non-failing and failing human heart. Cell Calcium. 2009 Feb; 45(2):144-54. PMID: 18947868.
    Citations: 17     Fields:    Translation:HumansCells
  32. Prunier F, Kawase Y, Gianni D, Scapin C, Danik SB, Ellinor PT, Hajjar RJ, Del Monte F. Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion. Circulation. 2008 Aug 05; 118(6):614-24. PMID: 18645052.
    Citations: 46     Fields:    Translation:AnimalsCells
  33. Del Monte F, Hajjar RJ. Intracellular devastation in heart failure. Heart Fail Rev. 2008 Jun; 13(2):151-62. PMID: 18347978.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  34. Haddad GE, Saunders L, Carles M, Crosby SD, del Monte F, Macgillivray TE, Semigran MJ, Dec GW, Hajjar RJ, Doye AA, Glass R, El M, Gwathmey JK. Fingerprint profile of alcohol-associated heart failure in human hearts. Alcohol Clin Exp Res. 2008 May; 32(5):814-21. PMID: 18336640.
    Citations: 4     Fields:    Translation:Humans
  35. Neilan TG, Ton-Nu TT, Kawase Y, Yoneyama R, Hoshino K, Del Monte F, Hajjar RJ, Picard MH, Levine RA, Hung J. Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexes. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2106-11. PMID: 18326805.
    Citations: 6     Fields:    Translation:Animals
  36. Haddad GE, Saunders LJ, Crosby SD, Carles M, del Monte F, King K, Bristow MR, Spinale FG, Macgillivray TE, Semigran MJ, Dec GW, Williams SA, Hajjar RJ, Gwathmey JK. Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences. Physiol Genomics. 2008 Apr 22; 33(2):267-77. PMID: 18303083.
    Citations: 12     Fields:    Translation:Humans
  37. Beeri R, Yosefy C, Guerrero JL, Nesta F, Abedat S, Chaput M, del Monte F, Handschumacher MD, Stroud R, Sullivan S, Pugatsch T, Gilon D, Vlahakes GJ, Spinale FG, Hajjar RJ, Levine RA. Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. J Am Coll Cardiol. 2008 Jan 29; 51(4):476-86. PMID: 18222360.
    Citations: 23     Fields:    Translation:AnimalsCells
  38. Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med. 2007 Aug; 13(8):962-9. PMID: 17632525.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  39. Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1581-9. PMID: 17526652.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  40. Cepollaro C, Lauretani F, Gozzini A, Masi L, Falchetti A, Del Monte F, Carbonell-Sala S, Tanini A, Corsi AM, Bandinelli S, Ferrucci L, Brandi ML. Relationship of volumetric bone mineral density and structural parameters with ERalpha gene polymorphisms. Calcif Tissue Int. 2007 May; 80(5):307-15. PMID: 17505773.
    Citations: 3     Fields:    Translation:Humans
  41. Palomeque J, Chemaly ER, Colosi P, Wellman JA, Zhou S, Del Monte F, Hajjar RJ. Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo. Gene Ther. 2007 Jul; 14(13):989-97. PMID: 17251988.
    Citations: 45     Fields:    Translation:AnimalsCells
  42. Sakata S, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF, Tsuji T, Takewa Y, del Monte F, Peluso R, Zsebo K, Jeong D, Park WJ, Kawase Y, Hajjar RJ. Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. J Mol Cell Cardiol. 2007 Apr; 42(4):852-61. PMID: 17300800.
    Citations: 53     Fields:    Translation:AnimalsCells
  43. Falchetti A, Sferrazza C, Cepollaro C, Gozzini A, Del Monte F, Masi L, Napoli N, Di Fede G, Cannone V, Cusumano G, Pandolfo MC, Rini GB, Tanini A, Brandi ML. FokI polymorphism of the vitamin D receptor gene correlates with parameters of bone mass and turnover in a female population of the Italian island of Lampedusa. Calcif Tissue Int. 2007 Jan; 80(1):15-20. PMID: 17164973.
    Citations: 10     Fields:    Translation:Humans
  44. Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang L, Nakajima-Takenaka C, Tsuji T, Konishi N, del Monte F, Hajjar RJ, Takaki M. Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1204-7. PMID: 17012346.
    Citations: 26     Fields:    Translation:AnimalsCells
  45. Prunier F, Pfister O, Hadri L, Liang L, Del Monte F, Liao R, Hajjar RJ. Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H522-9. PMID: 16997893.
    Citations: 24     Fields:    Translation:AnimalsCells
  46. Gregory KN, Ginsburg KS, Bodi I, Hahn H, Marreez YM, Song Q, Padmanabhan PA, Mitton BA, Waggoner JR, Del Monte F, Park WJ, Dorn GW, Bers DM, Kranias EG. Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function. J Mol Cell Cardiol. 2006 May; 40(5):653-65. PMID: 16600288.
    Citations: 31     Fields:    Translation:AnimalsCells
  47. Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF, Padmanabhan P, Konishi N, Takaki M, del Monte F, Hajjar RJ. Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Mol Ther. 2006 May; 13(5):987-96. PMID: 16503203.
    Citations: 17     Fields:    Translation:AnimalsCells
  48. Gianni D, Chan J, Gwathmey JK, del Monte F, Hajjar RJ. SERCA2a in heart failure: role and therapeutic prospects. J Bioenerg Biomembr. 2005 Dec; 37(6):375-80. PMID: 16691468.
    Citations: 11     Fields:    Translation:HumansAnimals
  49. Lipskaia L, del Monte F, Capiod T, Yacoubi S, Hadri L, Hours M, Hajjar RJ, Lompré AM. Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat. Circ Res. 2005 Sep 02; 97(5):488-95. PMID: 16081870.
    Citations: 40     Fields:    Translation:AnimalsCells
  50. Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings BA, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 2005 Aug; 115(8):2128-38. PMID: 16007268.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  51. Gorza L, del Monte F. Protein unfolding in cardiomyopathies. Heart Fail Clin. 2005 Jul; 1(2):237-50. PMID: 17386849.
    Citations: 3     Fields:    Translation:HumansCells
  52. Lebeche D, Dalal R, Jang M, del Monte F, Hajjar RJ. Transgenic models of heart failure: elucidation of the molecular mechanisms of heart disease. Heart Fail Clin. 2005 Jul; 1(2):219-36. PMID: 17386848.
    Citations:    Fields:    Translation:HumansAnimals
  53. Hayase M, Del Monte F, Kawase Y, Macneill BD, McGregor J, Yoneyama R, Hoshino K, Tsuji T, De Grand AM, Gwathmey JK, Frangioni JV, Hajjar RJ. Catheter-based antegrade intracoronary viral gene delivery with coronary venous blockade. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2995-3000. PMID: 15897329.
    Citations: 26     Fields:    Translation:AnimalsCells
  54. Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circ Res. 2005 Apr 15; 96(7):756-66. PMID: 15746443.
    Citations: 88     Fields:    Translation:AnimalsCells
  55. Bukhari F, MacGillivray T, del Monte F, Hajjar RJ. Genetic maneuvers to ameliorate ventricular function in heart failure: therapeutic potential and future implications. Expert Rev Cardiovasc Ther. 2005 Jan; 3(1):85-97. PMID: 15723577.
    Citations: 1     Fields:    Translation:HumansAnimals
  56. Harding SE, del Monte F, Hajjar RJ. Antisense strategies for treatment of heart failure. Methods Mol Med. 2005; 106:69-82. PMID: 15375313.
    Citations:    Fields:    Translation:HumansAnimalsCells
  57. Lebeche D, Kaprielian R, del Monte F, Tomaselli G, Gwathmey JK, Schwartz A, Hajjar RJ. In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis. Circulation. 2004 Nov 30; 110(22):3435-43. PMID: 15557376.
    Citations: 22     Fields:    Translation:AnimalsCells
  58. Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, del Monte F, Hajjar RJ, Linke WA. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res. 2004 Oct 01; 95(7):708-16. PMID: 15345656.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  59. del Monte F, Kizana E, Tabchy A, Hajjar RJ. Targeted gene transfer in heart failure: implications for novel gene identification. Curr Opin Mol Ther. 2004 Aug; 6(4):381-94. PMID: 15468597.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  60. Del Monte F, Dalal R, Tabchy A, Couget J, Bloch KD, Peterson R, Hajjar RJ. Transcriptional changes following restoration of SERCA2a levels in failing rat hearts. FASEB J. 2004 Sep; 18(12):1474-6. PMID: 15247151.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  61. Boecker W, Bernecker OY, Wu JC, Zhu X, Sawa T, Grazette L, Rosenzweig A, del Monte F, Schmidt U, Hajjar RJ. Cardiac-specific gene expression facilitated by an enhanced myosin light chain promoter. Mol Imaging. 2004 Apr; 3(2):69-75. PMID: 15296671.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  62. del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5622-7. PMID: 15044708.
    Citations: 71     Fields:    Translation:AnimalsCells
  63. Chaudhri BB, del Monte F, Harding SE, Hajjar RJ. Gene transfer in cardiac myocytes. Surg Clin North Am. 2004 Feb; 84(1):141-59, ix-x. PMID: 15053187.
    Citations: 5     Fields:    Translation:HumansCells
  64. Chaudhri B, del Monte F, Hajjar RJ, Harding SE. Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between adult rat and rabbit ventricular myocytes. Mol Cell Biochem. 2003 Sep; 251(1-2):103-9. PMID: 14575311.
    Citations: 3     Fields:    Translation:AnimalsCells
  65. Bernecker OY, del Monte F, Hajjar RJ. Gene therapy for the treatment of heart failure--calcium signaling. Semin Thorac Cardiovasc Surg. 2003 Jul; 15(3):268-76. PMID: 12973704.
    Citations: 1     Fields:    Translation:HumansCells
  66. del Monte F, Hajjar RJ. Targeting calcium cycling proteins in heart failure through gene transfer. J Physiol. 2003 Jan 01; 546(Pt 1):49-61. PMID: 12509478.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  67. del Monte F, Hajjar RJ. Efficient viral gene transfer to rodent hearts in vivo. Methods Mol Biol. 2003; 219:179-93. PMID: 12597008.
    Citations: 11     Fields:    Translation:AnimalsCells
  68. Harding SE, Del Monte F. Dissociation of hypertrophic growth from changes in myocyte contractile function. J Card Fail. 2002 Dec; 8(6 Suppl):S415-20. PMID: 12555154.
    Citations:    Fields:    Translation:HumansAnimalsCells
  69. Huq F, Del Monte F, Hajjar RJ. Modulating signaling pathways in hypertrophy and heart failure by gene transfer. J Card Fail. 2002 Dec; 8(6 Suppl):S389-400. PMID: 12555151.
    Citations: 1     Fields:    Translation:AnimalsCells
  70. Del Monte F, Johnson CM, Stepanek AC, Doye AA, Gwathmey JK. Defects in calcium control. J Card Fail. 2002 Dec; 8(6 Suppl):S421-31. PMID: 12555155.
    Citations: 5     Fields:    Translation:HumansAnimals
  71. Nakayama A, del Monte F, Hajjar RJ, Frangioni JV. Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Mol Imaging. 2002 Oct; 1(4):365-77. PMID: 12940233.
    Citations: 31     Fields:    Translation:HumansAnimals
  72. Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe PP, Hajjar RJ, Linke WA. Titin isoform switch in ischemic human heart disease. Circulation. 2002 Sep 10; 106(11):1333-41. PMID: 12221049.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  73. Chaudhri B, Del Monte F, Hajjar RJ, Harding SE. Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2450-7. PMID: 12388307.
    Citations: 2     Fields:    Translation:AnimalsCells
  74. Carr AN, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Jing SL, Allen PB, Greengard P, Yatani A, Hoit BD, Grupp IL, Hajjar RJ, DePaoli-Roach AA, Kranias EG. Type 1 phosphatase, a negative regulator of cardiac function. Mol Cell Biol. 2002 Jun; 22(12):4124-35. PMID: 12024026.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  75. del Monte F, Harding SE, Dec GW, Gwathmey JK, Hajjar RJ. Targeting phospholamban by gene transfer in human heart failure. Circulation. 2002 Feb 26; 105(8):904-7. PMID: 11864915.
    Citations: 67     Fields:    Translation:HumansCells
  76. Kaprielian R, del Monte F, Hajjar RJ. Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transfer. Basic Res Cardiol. 2002; 97 Suppl 1:I136-45. PMID: 12479247.
    Citations: 3     Fields:    Translation:HumansAnimals
  77. Del Monte F, Butler K, Boecker W, Gwathmey JK, Hajjar RJ. Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure. Physiol Genomics. 2002; 9(1):49-56. PMID: 11948290.
    Citations: 21     Fields:    Translation:AnimalsCells
  78. del Monte F, Williams E, Lebeche D, Schmidt U, Rosenzweig A, Gwathmey JK, Lewandowski ED, Hajjar RJ. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure. Circulation. 2001 Sep 18; 104(12):1424-9. PMID: 11560860.
    Citations: 93     Fields:    Translation:AnimalsCells
  79. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 2001 Jul 17; 104(3):330-5. PMID: 11457753.
    Citations: 177     Fields:    Translation:AnimalsCells
  80. del Monte F, Hajjar RJ, Harding SE. Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure. Circ Res. 2001 Jun 08; 88(11):E66-7. PMID: 11397790.
    Citations: 24     Fields:    Translation:AnimalsCells
  81. Davia K, Bernobich E, Ranu HK, del Monte F, Terracciano CM, MacLeod KT, Adamson DL, Chaudhri B, Hajjar RJ, Harding SE. SERCA2A overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes. J Mol Cell Cardiol. 2001 May; 33(5):1005-15. PMID: 11343422.
    Citations: 23     Fields:    Translation:AnimalsCells
  82. De Windt LJ, Lim HW, Bueno OF, Liang Q, Delling U, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, Molkentin JD. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3322-7. PMID: 11248077.
    Citations: 48     Fields:    Translation:AnimalsCells
  83. Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, Molkentin JD. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation. 2001 Feb 06; 103(5):670-7. PMID: 11156878.
    Citations: 129     Fields:    Translation:HumansCells
  84. Cheben P, del Monte F, Worsfold DJ, Carlsson DJ, Grover CP, Mackenzie JD. A photorefractive organically modified silica glass with high optical gain. Nature. 2000 Nov 02; 408(6808):64-7. PMID: 11081505.
    Citations:    Fields:    
  85. Hajjar RJ, del Monte F, Matsui T, Rosenzweig A. Prospects for gene therapy for heart failure. Circ Res. 2000 Mar 31; 86(6):616-21. PMID: 10746995.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  86. Schmidt U, del Monte F, Miyamoto MI, Matsui T, Gwathmey JK, Rosenzweig A, Hajjar RJ. Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase. Circulation. 2000 Feb 22; 101(7):790-6. PMID: 10683354.
    Citations: 44     Fields:    Translation:AnimalsCells
  87. Miyamoto MI, del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):793-8. PMID: 10639159.
    Citations: 124     Fields:    Translation:AnimalsCells
  88. Choukroun G, Hajjar R, Fry S, del Monte F, Haq S, Guerrero JL, Picard M, Rosenzweig A, Force T. Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases. J Clin Invest. 1999 Aug; 104(4):391-8. PMID: 10449431.
    Citations: 39     Fields:    Translation:AnimalsCells
  89. Picard S, Criniti A, Iwashiro K, Rouet R, Monti F, Tonelli E, Ruvolo G, Ducouret P, del Monte F, Papalia U, Puddu PE. Protection of human myocardium in vitro by K(ATP) activation with low concentrations of bimakalim. J Cardiovasc Pharmacol. 1999 Jul; 34(1):162-72. PMID: 10413083.
    Citations:    Fields:    Translation:Humans
  90. Force T, Hajjar R, Del Monte F, Rosenzweig A, Choukroun G. Signaling pathways mediating the response to hypertrophic stress in the heart. Gene Expr. 1999; 7(4-6):337-48. PMID: 10440234.
    Citations: 8     Fields:    Translation:AnimalsCells
  91. Harding SE, Davia K, Davies CH, del Monte F, Money-Kyrle AR, Poole-Wilson PA. From overload to failure: what happens inside the myocyte. Ann Med. 1998 Aug; 30 Suppl 1:14-23. PMID: 9800879.
    Citations:    Fields:    Translation:HumansAnimalsCells
  92. Cheben P, Nuã Ez A, Del Monte F, Levy D. Holographic diffraction gratings recording in organically modified silica gels: erratum. Opt Lett. 1997 Feb 01; 22(3):193. PMID: 18183146.
    Citations:    Fields:    
  93. Cheben P, Belenguer T, Nuñez A, Del Monte F, Levy D. Holographic diffraction gratings recording in organically modified silica gels. Opt Lett. 1996 Nov 15; 21(22):1857-9. PMID: 19881825.
    Citations:    Fields:    
  94. Wynne DG, Del Monte F, Harding SE. Cyclic AMP levels in ventricular myocytes from noradrenaline-treated guinea-pigs. Eur J Pharmacol. 1996 Aug 29; 310(2-3):235-42. PMID: 8884222.
    Citations: 3     Fields:    Translation:Animals
  95. Lefroy DC, Crake T, Del Monte F, Vescovo G, Dalla Libera L, Harding S, Poole-Wilson PA. Angiotensin II and contraction of isolated myocytes from human, guinea pig, and infarcted rat hearts. Am J Physiol. 1996 Jun; 270(6 Pt 2):H2060-9. PMID: 8764257.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  96. Harding SE, Brown LA, del Monte F, Davies CH, O'Gara P, Vescovo G, Wynne DG, Poole-Wilson PA. Acceleration of contraction by beta-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts. Basic Res Cardiol. 1996; 91 Suppl 2:53-6. PMID: 8957545.
    Citations: 3     Fields:    Translation:Humans
  97. Sanders L, Lynham JA, Bond B, del Monte F, Harding SE, Kaumann AJ. Sensitization of human atrial 5-HT4 receptors by chronic beta-blocker treatment. Circulation. 1995 Nov 01; 92(9):2526-39. PMID: 7586354.
    Citations: 20     Fields:    Translation:HumansCells
  98. Sugimoto S, Puddu PE, Monti F, Dawodu AA, del Monte F, Schiariti M, Campa PP, Marino B. Activation of ATP-dependent K+ channels enhances myocardial protection due to cold high potassium cardioplegia: a force-frequency relationship study. J Mol Cell Cardiol. 1995 Sep; 27(9):1867-81. PMID: 8523448.
    Citations: 1     Fields:    Translation:AnimalsCells
  99. del Monte F, O'Gara P, Poole-Wilson PA, Yacoub M, Harding SE. Cell geometry and contractile abnormalities of myocytes from failing human left ventricle. Cardiovasc Res. 1995 Aug; 30(2):281-90. PMID: 7585816.
    Citations: 16     Fields:    Translation:HumansCells
  100. Ferrara N, O'Gara P, Wynne DG, Brown LA, del Monte F, Poole-Wilson PA, Harding SE. Decreased contractile responses to isoproterenol in isolated cardiac myocytes from aging guinea-pigs. J Mol Cell Cardiol. 1995 May; 27(5):1141-50. PMID: 7473772.
    Citations: 6     Fields:    Translation:Animals
  101. Naqvi RU, del Monte F, O'Gara P, Harding SE, MacLeod KT. Characteristics of myocytes isolated from hearts of renovascular hypertensive guinea pigs. Am J Physiol. 1994 May; 266(5 Pt 2):H1886-95. PMID: 8203588.
    Citations:    Fields:    Translation:AnimalsCells
  102. del Monte F, Kaumann AJ, Poole-Wilson PA, Wynne DG, Pepper J, Harding SE. Coexistence of functioning beta 1- and beta 2-adrenoceptors in single myocytes from human ventricle. Circulation. 1993 Sep; 88(3):854-63. PMID: 8102599.
    Citations: 20     Fields:    Translation:HumansAnimals
  103. Del Monte F, Mynett JR, Sugden PH, Poole-Wilson PA, Harding SE. Subcellular mechanism of the species difference in the contractile response of ventricular myocytes to endothelin-1. Cardioscience. 1993 Sep; 4(3):185-91. PMID: 8400027.
    Citations: 2     Fields:    Translation:AnimalsCells
  104. Harding SE, Jones SM, Vescovo G, Del Monte F, Poole-Wilson PA. Reduced contractile responses to forskolin and a cyclic AMP analogue in myocytes from failing human ventricle. Eur J Pharmacol. 1992 Nov 13; 223(1):39-48. PMID: 1335876.
    Citations: 7     Fields:    Translation:Humans
  105. Monti F, Dawodu AA, Giglio V, Lanti M, del Monte F, Sugimoto S, Terracciano CM, Schiariti M, Puddu PE, Campa PP. [The inotropic and bathmotropic effects of beta stimulation: a study comparing dobutamine and dopamine on the guinea-pig papillary muscle in isotonic contraction]. Cardiologia. 1992 Sep; 37(9):635-9. PMID: 1292869.
    Citations:    Fields:    Translation:Animals
  106. Harding SE, Jones SM, O'Gara P, del Monte F, Vescovo G, Poole-Wilson PA. Isolated ventricular myocytes from failing and non-failing human heart; the relation of age and clinical status of patients to isoproterenol response. J Mol Cell Cardiol. 1992 May; 24(5):549-64. PMID: 1321914.
    Citations: 18     Fields:    Translation:HumansCells
  107. del Monte F, Harding SE, Puddu PE, Poole-Wilson PA. [Isolated cardiac myocytes: preparation and use in experimental cardiology]. Cardiologia. 1991 Apr; 36(4):319-29. PMID: 1933961.
    Citations:    Fields:    Translation:HumansAnimalsCells
  108. Jones SM, Hunt NA, Del Monte F, Harding SE. Contraction of cardiac myocytes from noradrenaline-treated rats in response to isoprenaline, forskolin and dibutyryl cAMP. Eur J Pharmacol. 1990 Nov 27; 191(2):129-40. PMID: 1964904.
    Citations: 5     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.