Harvard Catalyst Profiles

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Chih-Hao Lee, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI131659 (LEE, CHIH-HAO) Dec 12, 2017 - Nov 30, 2019
    Bioenergetic control in immune cell function
    Role: Principal Investigator
  2. R01DK113791 (LEE, CHIH-HAO) Jul 1, 2017 - Jun 30, 2020
    Cellular signaling in muscle metabolic adaptation and energy metabolism
    Role: Principal Investigator
  3. R01DK064750 (LEE, CHIH-HAO) Feb 20, 2010 - Sep 29, 2019
    Microgial Iron Metabolism and Its Regulation by Cannabinoids
    Role: Principal Investigator
  4. R01DK075046 (LEE, CHIH-HAO) Apr 1, 2006 - Sep 25, 2012
    PPAR Delta Functions in Liver
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nnah IC, Lee CH, Wessling-Resnick M. Iron potentiates microglial interleukin-1ß secretion induced by amyloid-ß. J Neurochem. 2019 Nov 06. PMID: 31693761.
  2. McCarthy RC, Sosa JC, Gardeck AM, Baez AS, Lee CH, Wessling-Resnick M. Inflammation-induced iron transport and metabolism by brain microglia. J Biol Chem. 2018 05 18; 293(20):7853-7863. PMID: 29610275.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018 03 22; 173(1):117-129.e14. PMID: 29570992.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Dai L, Bhargava P, Stanya KJ, Alexander RK, Liou YH, Jacobi D, Knudsen NH, Hyde A, Gangl MR, Liu S, Lee CH. Macrophage alternative activation confers protection against lipotoxicity-induced cell death. Mol Metab. 2017 10; 6(10):1186-1197. PMID: 29031719.
  5. Jiang Z, Knudsen NH, Wang G, Qiu W, Naing ZZC, Bai Y, Ai X, Lee CH, Zhou X. Genetic Control of Fatty Acid ß-Oxidation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2017 06; 56(6):738-748. PMID: 28199134.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Wang DD, Toledo E, Hruby A, Rosner BA, Willett WC, Sun Q, Razquin C, Zheng Y, Ruiz-Canela M, Guasch-Ferré M, Corella D, Gómez-Gracia E, Fiol M, Estruch R, Ros E, Lapetra J, Fito M, Aros F, Serra-Majem L, Lee CH, Clish CB, Liang L, Salas-Salvadó J, Martínez-González MA, Hu FB. Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea). Circulation. 2017 May 23; 135(21):2028-2040. PMID: 28280233.
    Citations: 9     Fields:    Translation:Humans
  7. Brace LE, Vose SC, Stanya K, Gathungu RM, Marur VR, Longchamp A, Treviño-Villarreal H, Mejia P, Vargas D, Inouye K, Bronson RT, Lee CH, Neilan E, Kristal BS, Mitchell JR. Increased oxidative phosphorylation in response to acute and chronic DNA damage. NPJ Aging Mech Dis. 2016; 2:16022. PMID: 28721274.
    Citations: 7     
  8. Knudsen NH, Lee CH. Identity Crisis: CD301b(+) Mononuclear Phagocytes Blur the M1-M2 Macrophage Line. Immunity. 2016 09 20; 45(3):461-463. PMID: 27653596.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. McCarthy RC, Lu DY, Alkhateeb A, Gardeck AM, Lee CH, Wessling-Resnick M. Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. J Neuroinflammation. 2016 Jan 27; 13:21. PMID: 26819091.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metab. 2015 Dec 01; 22(6):1045-58. PMID: 26481668.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  11. Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kong X, Hyde AL, Gangl MR, Mair WB, Lee CH. Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness. Cell Metab. 2015 Oct 06; 22(4):709-20. PMID: 26365180.
    Citations: 31     Fields:    Translation:AnimalsCells
  12. Liu S, Alexander RK, Lee CH. Lipid metabolites as metabolic messengers in inter-organ communication. Trends Endocrinol Metab. 2014 Jul; 25(7):356-63. PMID: 24895003.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  13. Knudsen NH, Lee CH. IL-21 and IRF4: A complex partnership in immune and metabolic regulation. Diabetes. 2014 Jun; 63(6):1838-40. PMID: 24853897.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Knudsen NH, Lee CH. STAT4: an initiator of meta-inflammation in adipose tissue? Diabetes. 2013 Dec; 62(12):4002-3. PMID: 24264401.
    Citations: 1     Fields:    Translation:Animals
  15. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013 Oct 24; 502(7472):550-4. PMID: 24153306.
    Citations: 56     Fields:    Translation:AnimalsCells
  16. Jia X, Kim J, Veuthey T, Lee CH, Wessling-Resnick M. Glucose metabolism in the Belgrade rat, a model of iron-loading anemia. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15; 304(12):G1095-102. PMID: 23599042.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Caradonna KL, Engel JC, Jacobi D, Lee CH, Burleigh BA. Host metabolism regulates intracellular growth of Trypanosoma cruzi. Cell Host Microbe. 2013 Jan 16; 13(1):108-17. PMID: 23332160.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  18. Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie AN, Lee CH. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest. 2013 Jan; 123(1):261-71. PMID: 23257358.
    Citations: 41     Fields:    Translation:AnimalsCells
  19. Kim J, Jia X, Buckett PD, Liu S, Lee CH, Wessling-Resnick M. Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia. FASEB J. 2013 Apr; 27(4):1657-63. PMID: 23241313.
    Citations: 8     Fields:    Translation:Animals
  20. Bhargava P, Li C, Stanya KJ, Jacobi D, Dai L, Liu S, Gangl MR, Harn DA, Lee CH. Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways. Nat Med. 2012 Nov; 18(11):1665-72. PMID: 23104131.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  21. Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP. A PML–PPAR-d pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med. 2012 Sep; 18(9):1350-8. PMID: 22902876.
    Citations: 159     Fields:    Translation:AnimalsCells
  22. Liu S, Reilly SM, Lee CH. Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressor. Antioxid Redox Signal. 2013 Jul 20; 19(3):299-309. PMID: 22703297.
    Citations:    Fields:    Translation:HumansAnimalsCells
  23. Zhang Y, Li Y, Niepel MW, Kawano Y, Han S, Liu S, Marsili A, Larsen PR, Lee CH, Cohen DE. Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5417-22. PMID: 22427358.
    Citations: 31     Fields:    Translation:AnimalsCells
  24. Bhargava P, Lee CH. Role and function of macrophages in the metabolic syndrome. Biochem J. 2012 Mar 01; 442(2):253-62. PMID: 22329799.
    Citations: 26     Fields:    Translation:HumansCells
  25. Jacobi D, Stanya KJ, Lee CH. Adipose tissue signaling by nuclear receptors in metabolic complications of obesity. Adipocyte. 2012; 1(1):4-12. PMID: 22916336.
    Citations: 10     Fields:    
  26. Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab. 2011 Jul 06; 14(1):21-32. PMID: 21723501.
    Citations: 155     Fields:    Translation:AnimalsCells
  27. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010 Dec 01; 12(6):643-53. PMID: 21109196.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  28. Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem. 2011 Jan 14; 286(2):1237-47. PMID: 21059653.
    Citations: 42     Fields:    Translation:AnimalsCells
  29. Qi L, Cornelis MC, Kraft P, Stanya KJ, Linda Kao WH, Pankow JS, Dupuis J, Florez JC, Fox CS, Paré G, Sun Q, Girman CJ, Laurie CC, Mirel DB, Manolio TA, Chasman DI, Boerwinkle E, Ridker PM, Hunter DJ, Meigs JB, Lee CH, Hu FB, van Dam RM. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet. 2010 Jul 01; 19(13):2706-15. PMID: 20418489.
    Citations: 99     Fields:    Translation:HumansCells
  30. Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN. Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1660-5. PMID: 20080636.
    Citations: 201     Fields:    Translation:HumansCells
  31. Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D, Lee CH, Hu FB. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. Diabetes. 2008 Nov; 57(11):3145-51. PMID: 18647953.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  32. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008 Jun; 7(6):485-95. PMID: 18522830.
    Citations: 233     Fields:    Translation:AnimalsCells
  33. Reilly SM, Lee CH. PPAR delta as a therapeutic target in metabolic disease. FEBS Lett. 2008 Jan 09; 582(1):26-31. PMID: 18036566.
    Citations: 39     Fields:    Translation:Humans
  34. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. PMID: 16492734.
    Citations: 141     Fields:    Translation:AnimalsCells
  35. Lee CH, Kang K, Mehl IR, Nofsinger R, Alaynick WA, Chong LW, Rosenfeld JM, Evans RM. Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2434-9. PMID: 16467150.
    Citations: 29     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.