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Garrick Colin Stewart, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cascino TM, Kittleson MM, Lala A, Stehlik J, Palardy M, Pamboukian SV, Ewald GA, Mountis MM, Horstmanshof DA, Robinson SW, Shah P, Jorde UP, McLean RC, Richards B, Khalatbari S, Spino C, Taddei-Peters WC, Grady KL, Mann DL, Stevenson LW, Stewart GC, Aaronson KD. Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients: REVIVAL (Registry Evaluation of Vital Information for VADs in Ambulatory Life REVIVAL). Circ Heart Fail. 2020 May; 13(5):e006858. PMID: 32418478.
    Citations:    
  2. Cruz Rodriguez JB, Stewart GC, Pamboukian SV, Tallaj JA, Rajapreyar I, Kirklin JK, Holman WL, Hoopes CW, Mukherjee D, Mallawaarachchi I, Dwivedi A, Acharya D. Clinical characteristics and outcomes of patients requiring prolonged inotropes after left ventricular assist device implantation. Artif Organs. 2020 Apr 03. PMID: 32242954.
    Citations:    
  3. Vieira JL, Pfeffer M, Claggett BL, Stewart GC, Givertz MM, Coakley L, Mallidi HR, Mehra MR. The impact of statin therapy on neurological events following left ventricular assist system implantation in advanced heart failure. J Heart Lung Transplant. 2020 Jun; 39(6):582-592. PMID: 32220561.
    Citations:    
  4. Stewart GC. Body Fat and Fitness for Ventricular Assist Device Therapy. J Card Fail. 2020 Apr; 26(4):298-299. PMID: 32036022.
    Citations:    
  5. Tchoukina I, Shah KB, Thibodeau JT, Estep JD, Lala A, Lanfear DE, Gilotra NA, Pamboukian SV, Horstmanshof DA, Mcnamara DM, Haas DC, Jorde UP, Mclean RC, Cascino TM, Khalatbari S, Richards B, Yosef M, Spino C, Baldwin JT, Mann DL, Aaronson KD, Stewart GC. Impact of Socioeconomic Factors on Patient Desire for Early LVAD Therapy Prior to Inotrope Dependence. J Card Fail. 2020 Apr; 26(4):316-323. PMID: 31809791.
    Citations:    
  6. Stehlik J, Mountis M, Haas D, Palardy M, Ambardekar AV, Estep JD, Ewald G, Russell SD, Robinson S, Jorde U, Taddei-Peters WC, Jeffries N, Richards B, Khalatbari S, Spino C, Baldwin JT, Mann D, Stewart GC, Aaronson KD. Quality of life and treatment preference for ventricular assist device therapy in ambulatory advanced heart failure: A report from the REVIVAL study. J Heart Lung Transplant. 2020 01; 39(1):27-36. PMID: 31822442.
    Citations:    
  7. Cascino TM, Aaronson KD, Stewart GC. Identifying Stage D Heart Failure: Data From the Most Recent Registries. Curr Heart Fail Rep. 2019 10; 16(5):130-139. PMID: 31250278.
    Citations:    
  8. Almarzooq ZI, Varshney AS, Vaduganathan M, Pareek M, Stewart GC, Estep JD, Mehra MR. Expanding the Scope of Multimodality Imaging in Durable Mechanical Circulatory Support. JACC Cardiovasc Imaging. 2020 Apr; 13(4):1069-1081. PMID: 31542528.
    Citations:    
  9. Aaronson KD, Stewart GC, Pagani FD, Stevenson LW, Palardy M, McNamara DM, Mancini DM, Grady K, Gorcsan J, Kormos R, Jeffries N, Taddei-Peters WC, Richards B, Khalatbari S, Spino C, Baldwin JT, Mann DL. Registry Evaluation of Vital Information for VADs in Ambulatory Life (REVIVAL): Rationale, design, baseline characteristics, and inclusion criteria performance. J Heart Lung Transplant. 2020 01; 39(1):7-15. PMID: 31679943.
    Citations:    
  10. Kittleson MM, Shah P, Lala A, McLean RC, Pamboukian S, Horstmanshof DA, Thibodeau J, Shah K, Teuteberg J, Gilotra NA, Taddei-Peters WC, Cascino TM, Richards B, Khalatbari S, Jeffries N, Stevenson LW, Mann D, Aaronson KD, Stewart GC. INTERMACS profiles and outcomes of ambulatory advanced heart failure patients: A report from the REVIVAL Registry. J Heart Lung Transplant. 2020 01; 39(1):16-26. PMID: 31522912.
    Citations:    
  11. Bonaca MP, Olenchock BA, Salem JE, Wiviott SD, Ederhy S, Cohen A, Stewart GC, Choueiri TK, Di Carli M, Allenbach Y, Kumbhani DJ, Heinzerling L, Amiri-Kordestani L, Lyon AR, Thavendiranathan P, Padera R, Lichtman A, Liu PP, Johnson DB, Moslehi J. Myocarditis in the Setting of Cancer Therapeutics: Proposed Case Definitions for Emerging Clinical Syndromes in Cardio-Oncology Circulation. 2019 07 02; 140(2):80-91. PMID: 31390169.
    Citations:    
  12. Bravo PE, Bajaj N, Padera RF, Morgan V, Hainer J, Bibbo CF, Harrington M, Park MA, Hyun H, Robertson M, Lakdawala NK, Groarke J, Stewart GC, Dorbala S, Blankstein R, Di Carli MF. Feasibility of somatostatin receptor-targeted imaging for detection of myocardial inflammation: A pilot study. J Nucl Cardiol. 2019 Jun 13. PMID: 31197742.
    Citations:    
  13. Divakaran S, Stewart GC, Lakdawala NK, Padera RF, Zhou W, Desai AS, Givertz MM, Mehra MR, Kwong RY, Hedgire SS, Ghoshhajra BB, Taqueti VR, Skali H, Dorbala S, Blankstein R, Di Carli MF. Diagnostic Accuracy of Advanced Imaging in Cardiac Sarcoidosis. Circ Cardiovasc Imaging. 2019 06; 12(6):e008975. PMID: 31177817.
    Citations:    
  14. Stewart GC, Cascino T, Richards B, Khalatbari S, Mann DL, Taddei-Peters WC, Baldwin JT, Jeffries NO, Spino C, Stevenson LW, Aaronson KD. Ambulatory Advanced Heart Failure in Women: A Report From the REVIVAL Registry. JACC Heart Fail. 2019 07; 7(7):602-611. PMID: 31078480.
    Citations:    
  15. Nemer DM, Stewart GC, Puligandla M, Neuberg DS, Givertz MM, Mehra MR, Couper GS, Connors JM. Postoperative bridging anticoagulation and left ventricular assist system thrombosis. J Thromb Thrombolysis. 2019 Jan; 47(1):57-66. PMID: 30255419.
    Citations:    Fields:    
  16. Snipelisky D, Chaudhry SP, Stewart GC. The Many Faces of Heart Failure. Card Electrophysiol Clin. 2019 03; 11(1):11-20. PMID: 30717842.
    Citations:    
  17. Stewart GC. Finding the Right Time and Place to Vent. JACC Heart Fail. 2018 12; 6(12):1044-1046. PMID: 30497644.
    Citations:    
  18. Ambardekar AV, Kittleson MM, Palardy M, Mountis MM, Forde-McLean RC, DeVore AD, Pamboukian SV, Thibodeau JT, Teuteberg JJ, Cadaret L, Xie R, Taddei-Peters W, Naftel DC, Kirklin JK, Stevenson LW, Stewart GC. Outcomes with ambulatory advanced heart failure from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry. J Heart Lung Transplant. 2019 04; 38(4):408-417. PMID: 30948210.
    Citations:    
  19. Rimsans J, Levesque A, Lyons E, Sylvester K, Givertz MM, Mehra MR, Stewart GC, Connors JM. Four factor prothrombin complex concentrate for warfarin reversal in patients with left ventricular assist devices. J Thromb Thrombolysis. 2018 Aug; 46(2):180-185. PMID: 29785470.
    Citations:    Fields:    Translation:Humans
  20. Stewart GC. Editorial commentary: Weaving palliative care into the fabric of heart failure management. Trends Cardiovasc Med. 2018 10; 28(7):451-452. PMID: 29753635.
    Citations:    Fields:    
  21. Berg DD, Vaduganathan M, Upadhyay GA, Singh JP, Mehra MR, Stewart GC. Cardiac Implantable Electronic Devices in Patients With Left Ventricular Assist Systems. J Am Coll Cardiol. 2018 04 03; 71(13):1483-1493. PMID: 29598870.
    Citations:    Fields:    
  22. Levesque AA, Rimsans JM, Sylvester KW, Lyons EN, Frankel KA, Coakley LL, Hickey M, Montoya KA, Mehra MR, Givertz MM, Stewart GC, Connors JM. Development of an Outpatient Guideline for Optimal Anticoagulation Bridging in Patients With Durable Mechanical Circulatory Support. Crit Pathw Cardiol. 2018 03; 17(1):32-37. PMID: 29432374.
    Citations:    Fields:    
  23. Vita T, Okada DR, Veillet-Chowdhury M, Bravo PE, Mullins E, Hulten E, Agrawal M, Madan R, Taqueti VR, Steigner M, Skali H, Kwong RY, Stewart GC, Dorbala S, Di Carli MF, Blankstein R. Complementary Value of Cardiac Magnetic Resonance Imaging and Positron Emission Tomography/Computed Tomography in the Assessment of Cardiac Sarcoidosis. Circ Cardiovasc Imaging. 2018 01; 11(1):e007030. PMID: 29335272.
    Citations: 2     Fields:    
  24. Stewart GC, Ambardekar AV, Kittleson MM. Defining Ambulatory Advanced Heart Failure: MedaMACS and Beyond. Curr Heart Fail Rep. 2017 12; 14(6):498-506. PMID: 28952014.
    Citations:    Fields:    Translation:Humans
  25. Wadhera RK, Stewart GC, O'Gara PT. A 52-Year-Old Man With Unheralded Syncope. JAMA Cardiol. 2017 Dec 01; 2(12):1394-1395. PMID: 29049514.
    Citations:    Fields:    
  26. DeVore AD, Stewart GC. The Risk of Stroke on Left Ventricular Assist Device Support: Steady Gains or Stalled Progress? JACC Heart Fail. 2017 10; 5(10):712-714. PMID: 28958346.
    Citations:    Fields:    
  27. Ambardekar AV, Thibodeau JT, DeVore AD, Kittleson MM, Forde-McLean RC, Palardy M, Mountis MM, Cadaret L, Teuteberg JJ, Pamboukian SV, Xie R, Stevenson LW, Stewart GC. Discordant Perceptions of Prognosis and Treatment Options Between Physicians and Patients With Advanced Heart Failure. JACC Heart Fail. 2017 09; 5(9):663-671. PMID: 28822745.
    Citations: 3     Fields:    Translation:Humans
  28. Kim M, Bergmark BA, Zelniker TA, Mehra MR, Stewart GC, Page DS, Woodcome EL, Smallwood JA, Gabardi S, Givertz MM. Early aspirin use and the development of cardiac allograft vasculopathy. J Heart Lung Transplant. 2017 Dec; 36(12):1344-1349. PMID: 28781013.
    Citations:    Fields:    Translation:Humans
  29. Chaudhry SP, Stewart GC. New pharmacological and technological management strategies in heart failure. Vasc Health Risk Manag. 2017; 13:111-121. PMID: 28356751.
    Citations:    Fields:    Translation:HumansAnimals
  30. Stewart GC. Learning From Our Predictions: The HeartMate Risk Score in INTERMACS. JACC Heart Fail. 2016 12; 4(12):959-961. PMID: 27816510.
    Citations:    Fields:    Translation:Humans
  31. Stewart GC, Kittleson MM, Patel PC, Cowger JA, Patel CB, Mountis MM, Johnson FL, Guglin ME, Rame JE, Teuteberg JJ, Stevenson LW. INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) Profiling Identifies Ambulatory Patients at High Risk on Medical Therapy After Hospitalizations for Heart Failure. Circ Heart Fail. 2016 Nov; 9(11). PMID: 27834198.
    Citations: 3     Fields:    
  32. Stewart GC. Putting Life in the Years: Incorporating Quality of Life Into Left Ventricular Assist Devices Outcomes. Circ Heart Fail. 2016 08; 9(8). PMID: 27507114.
    Citations:    Fields:    Translation:Humans
  33. Chaudhry SP, Stewart GC. Advanced Heart Failure: Prevalence, Natural History, and Prognosis. Heart Fail Clin. 2016 Jul; 12(3):323-33. PMID: 27371510.
    Citations: 1     Fields:    Translation:Humans
  34. Joyce E, Chung C, Badloe S, Odutayo K, Desai A, Givertz MM, Nohria A, Lakdawala NK, Stewart GC, Young M, Weintraub J, Stevenson LW, Lewis EF. Variable Contribution of Heart Failure to Quality of Life in Ambulatory Heart Failure With Reduced, Better, or Preserved Ejection Fraction. JACC Heart Fail. 2016 Mar; 4(3):184-93. PMID: 26874379.
    Citations: 3     Fields:    Translation:Humans
  35. Ambardekar AV, Forde-McLean RC, Kittleson MM, Stewart GC, Palardy M, Thibodeau JT, DeVore AD, Mountis MM, Cadaret L, Teuteberg JJ, Pamboukian SV, Cantor RS, Lindenfeld J. High early event rates in patients with questionable eligibility for advanced heart failure therapies: Results from the Medical Arm of Mechanically Assisted Circulatory Support (Medamacs) Registry. J Heart Lung Transplant. 2016 06; 35(6):722-30. PMID: 26987599.
    Citations: 4     Fields:    Translation:Humans
  36. Stewart GC, Givertz MM, Mehra MR. Pump thrombosis redux. J Heart Lung Transplant. 2015 Dec; 34(12):1511-4. PMID: 26681120.
    Citations:    Fields:    Translation:Humans
  37. Joyce E, Stewart GC, Hickey M, Coakley L, Rivero JM, Gosev I, Givertz MM, Couper GS, Mehra MR. Left ventricular dimension decrement index early after axial flow assist device implantation: A novel risk marker for late pump thrombosis. J Heart Lung Transplant. 2015 Dec; 34(12):1561-9. PMID: 26508725.
    Citations: 1     Fields:    Translation:Humans
  38. Stewart GC. Mapping the Terrain of Competing Risk Following Primary Prevention Defibrillator Implantation. Circ Heart Fail. 2015 Sep; 8(5):847-9. PMID: 26374916.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  39. Stewart GC. Finding traction for mechanical circulatory support during coronary interventions. Circulation. 2015 Sep 29; 132(13):1221-3. PMID: 26286904.
    Citations:    Fields:    Translation:Humans
  40. Stewart GC, Kittleson MM, Cowger JA, Johnson FL, Patel CB, Mountis MM, Patel PC, Rame JE, Testani J, Guglin ME, Teuteberg JJ, Stevenson LW. Who wants a left ventricular assist device for ambulatory heart failure? Early insights from the MEDAMACS screening pilot. J Heart Lung Transplant. 2015 Dec; 34(12):1630-3. PMID: 26321249.
    Citations: 7     Fields:    Translation:Humans
  41. Chen CY, Stevenson LW, Stewart GC, Bhatt DL, Desai M, Seeger JD, Williams L, Jalbert JJ, Setoguchi S. Real world effectiveness of primary implantable cardioverter defibrillators implanted during hospital admissions for exacerbation of heart failure or other acute co-morbidities: cohort study of older patients with heart failure. BMJ. 2015 Jul 14; 351:h3529. PMID: 26174233.
    Citations: 5     Fields:    Translation:Humans
  42. Abbasi SA, Cheezum MK, Ghosh N, Stewart GC, Di Carli MF. Multimodality imaging of hypertrophic cardiomyopathy in a transplanted heart. Circulation. 2014 Sep 16; 130(12):1010-3. PMID: 25223773.
    Citations:    Fields:    Translation:Humans
  43. Waller AH, Dunne R, Stewart GC, Ghosh N, Gosev I, Rybicki FJ, Blankstein R, Couper GS, Steigner M. Evaluation of bend relief disconnection in patients supported by a HeartMate II left ventricular assist device. Circ Cardiovasc Imaging. 2014 Sep; 7(5):844-8. PMID: 25227237.
    Citations:    Fields:    Translation:Humans
  44. Setoguchi S, Warner Stevenson L, Stewart GC, Bhatt DL, Epstein AE, Desai M, Williams LA, Chen CY. Influence of healthy candidate bias in assessing clinical effectiveness for implantable cardioverter-defibrillators: cohort study of older patients with heart failure. BMJ. 2014 May 08; 348:g2866. PMID: 24812112.
    Citations: 7     Fields:    Translation:Humans
  45. Stewart GC, Mayer JE. Heart transplantation in adults with congenital heart disease. Heart Fail Clin. 2014 Jan; 10(1):207-18. PMID: 24275305.
    Citations: 2     Fields:    Translation:Humans
  46. Mehra MR, Stewart GC, Uber PA. The vexing problem of thrombosis in long-term mechanical circulatory support. J Heart Lung Transplant. 2014 Jan; 33(1):1-11. PMID: 24418729.
    Citations: 21     Fields:    Translation:Humans
  47. Osborne MT, Hulten EA, Singh A, Waller AH, Bittencourt MS, Stewart GC, Hainer J, Murthy VL, Skali H, Dorbala S, Di Carli MF, Blankstein R. Reduction in ¹8F-fluorodeoxyglucose uptake on serial cardiac positron emission tomography is associated with improved left ventricular ejection fraction in patients with cardiac sarcoidosis. J Nucl Cardiol. 2014 Feb; 21(1):166-74. PMID: 24307261.
    Citations: 33     Fields:    Translation:Humans
  48. Liao JM, Stewart GC, Padera RF, Miller AL, Loscalzo J. Clinical problem-solving. A curious case of chest pain. N Engl J Med. 2013 Nov 07; 369(19):1844-50. PMID: 24195552.
    Citations:    Fields:    Translation:Humans
  49. Aday AW, Liao JM, Padera RF, Vaidya A, Stewart GC. Interactive medical case. A curious case of chest pain. N Engl J Med. 2013 Oct 17; 369(16):e21. PMID: 24131196.
    Citations:    Fields:    Translation:Humans
  50. Stewart GC, Mehra MR. A history of devices as an alternative to heart transplantation. Heart Fail Clin. 2014 Jan; 10(1 Suppl):S1-12. PMID: 24262348.
    Citations:    Fields:    Translation:HumansAnimals
  51. Teuteberg JJ, Stewart GC, Jessup M, Kormos RL, Sun B, Frazier OH, Naftel DC, Stevenson LW. Implant strategies change over time and impact outcomes: insights from the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). JACC Heart Fail. 2013 Oct; 1(5):369-78. PMID: 24621968.
    Citations: 10     Fields:    Translation:Humans
  52. Stewart GC, Stevenson LW. INTERMACS and MedaMACS: how will they guide future therapy? Curr Cardiol Rep. 2013 Sep; 15(9):394. PMID: 23881578.
    Citations: 3     Fields:    Translation:Humans
  53. Chen CY, Stevenson LW, Stewart GC, Seeger JD, Williams L, Jalbert JJ, Setoguchi S. Impact of baseline heart failure burden on post-implantable cardioverter-defibrillator mortality among medicare beneficiaries. J Am Coll Cardiol. 2013 May 28; 61(21):2142-50. PMID: 23541973.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  54. Stewart GC. Management of peripartum cardiomyopathy. Curr Treat Options Cardiovasc Med. 2012 Dec; 14(6):622-36. PMID: 23007906.
    Citations:    
  55. Gottumukkala RV, Lv H, Cornivelli L, Wagers AJ, Kwong RY, Bronson R, Stewart GC, Schulze PC, Chutkow W, Wolpert HA, Lee RT, Lipes MA. Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes. Sci Transl Med. 2012 Jun 13; 4(138):138ra80. PMID: 22700956.
    Citations: 8     Fields:    Translation:Animals
  56. Stewart GC, Givertz MM. Mechanical circulatory support for advanced heart failure: patients and technology in evolution. Circulation. 2012 Mar 13; 125(10):1304-15. PMID: 22412091.
    Citations: 29     Fields:    Translation:Humans
  57. Stewart GC, Stevenson LW. Keeping left ventricular assist device acceleration on track. Circulation. 2011 Apr 12; 123(14):1559-68; discussion 1568. PMID: 21482974.
    Citations: 11     Fields:    Translation:Humans
  58. Stewart GC, Lopez-Molina J, Gottumukkala RV, Rosner GF, Anello MS, Hecht JL, Winters GL, Padera RF, Baughman KL, Lipes MA. Myocardial parvovirus B19 persistence: lack of association with clinicopathologic phenotype in adults with heart failure. Circ Heart Fail. 2011 Jan; 4(1):71-8. PMID: 21097605.
    Citations: 14     Fields:    Translation:HumansCells
  59. Stewart GC, Weintraub JR, Pratibhu PP, Semigran MJ, Camuso JM, Brooks K, Tsang SW, Anello MS, Nguyen VT, Lewis EF, Nohria A, Desai AS, Givertz MM, Stevenson LW. Patient expectations from implantable defibrillators to prevent death in heart failure. J Card Fail. 2010 Feb; 16(2):106-13. PMID: 20142021.
    Citations: 13     Fields:    Translation:Humans
  60. Al Habeeb W, Stewart GC, Mudge GH. Management of end-stage heart failure: a perspective on the Arab Gulf states. Ann Saudi Med. 2009 Nov-Dec; 29(6):460-6. PMID: 19847084.
    Citations: 1     Fields:    Translation:Humans
  61. Wilson SR, Givertz MM, Stewart GC, Mudge GH. Ventricular assist devices the challenges of outpatient management. J Am Coll Cardiol. 2009 Oct 27; 54(18):1647-59. PMID: 19850205.
    Citations: 18     Fields:    Translation:Humans
  62. Stewart GC, Brooks K, Pratibhu PP, Tsang SW, Semigran MJ, Smith CM, Saniuk C, Camuso JM, Fang JC, Mudge GH, Couper GS, Baughman KL, Stevenson LW. Thresholds of physical activity and life expectancy for patients considering destination ventricular assist devices. J Heart Lung Transplant. 2009 Sep; 28(9):863-9. PMID: 19716036.
    Citations: 6     Fields:    Translation:Humans
  63. Wilson SR, Mudge GH, Stewart GC, Givertz MM. Evaluation for a ventricular assist device: selecting the appropriate candidate. Circulation. 2009 Apr 28; 119(16):2225-32. PMID: 19398678.
    Citations: 9     Fields:    Translation:Humans
  64. Stewart GC, Nohria A. Images in clinical medicine. Giant left atrium. N Engl J Med. 2008 May 08; 358(19):2050. PMID: 18463381.
    Citations:    Fields:    Translation:Humans
  65. Donahoe SM, Stewart GC, McCabe CH, Mohanavelu S, Murphy SA, Cannon CP, Antman EM. Diabetes and mortality following acute coronary syndromes. JAMA. 2007 Aug 15; 298(7):765-75. PMID: 17699010.
    Citations: 121     Fields:    Translation:Humans
  66. Saavedra WF, Paolocci N, St John ME, Skaf MW, Stewart GC, Xie JS, Harrison RW, Zeichner J, Mudrick D, Marbán E, Kass DA, Hare JM. Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res. 2002 Feb 22; 90(3):297-304. PMID: 11861418.
    Citations: 53     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.