Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Xiaozhe Han, Ph.D., D.M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DE025255 (HAN, XIAOZHE) Jun 13, 2019 - May 31, 2021
    Regulatory B cells in the amelioration of immune-mediated periodontal disease
    Role: Principal Investigator
  2. R56DE023807 (HAN, XIAOZHE) Aug 5, 2014 - Jan 31, 2016
    Regulatory B cells in the amelioration of immune-mediated periodontal disease
    Role: Principal Investigator
  3. R21DE021837 (HAN, XIAOZHE) Jul 1, 2011 - Jun 30, 2013
    Regulation of B-Cell Apoptosis by TLR Signaling in Periodontal Disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yu P, Wang W, Zhuang Z, Xie N, Xu J, Wang C, Hou J, Han X, Liu X. A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score. Histopathology. 2019 Apr; 74(5):766-779. PMID: 30444275.
    Citations: 1     Fields:    Translation:Humans
  2. Zhao Q, Hu Y, Deng S, Yu P, Chen B, Wang Z, Han X. Cytidine-phosphate-guanosine oligodeoxynucleotides in combination with CD40 ligand decrease periodontal inflammation and alveolar bone loss in a TLR9-independent manner. J Appl Oral Sci. 2018; 26:e20170451. PMID: 29791566.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Ishii T, Ruiz-Torruella M, Ikeda A, Shindo S, Movila A, Mawardi H, Albassam A, Kayal RA, Al-Dharrab AA, Egashira K, Wisitrasameewong W, Yamamoto K, Mira AI, Sueishi K, Han X, Taubman MA, Miyamoto T, Kawai T. OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9. FASEB J. 2018 07; 32(7):4016-4030. PMID: 29533736.
    Citations: 10     Fields:    Translation:AnimalsCells
  4. Jiang S, Hu Y, Deng S, Deng J, Yu X, Huang G, Kawai T, Han X. miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6. Biochim Biophys Acta Mol Basis Dis. 2018 Mar; 1864(3):925-933. PMID: 29288795.
    Citations: 6     Fields:    Translation:AnimalsCells
  5. Wang Y, Shang S, Sun Q, Chen J, Du G, Nie H, Han X, Tang G. Increased infiltration of CD11 c+/CD123+ dendritic cell subsets and upregulation of TLR/IFN-a signaling participate in pathogenesis of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 05; 125(5):459-467.e2. PMID: 29429903.
    Citations: 2     Fields:    Translation:HumansCells
  6. Du G, Chen J, Wang Y, Cao T, Zhou L, Wang Y, Han X, Tang G. Differential expression of STAT-3 in subtypes of oral lichen planus: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 03; 125(3):236-243.e1. PMID: 29269258.
    Citations: 1     Fields:    Translation:HumansCells
  7. Yu X, Hu Y, Freire M, Yu P, Kawai T, Han X. Role of toll-like receptor 2 in inflammation and alveolar bone loss in experimental peri-implantitis versus periodontitis. J Periodontal Res. 2018 Feb; 53(1):98-106. PMID: 28872184.
    Citations: 10     Fields:    Translation:Animals
  8. Lin M, Hu Y, Wang Y, Kawai T, Wang Z, Han X. Different engagement of TLR2 and TLR4 in Porphyromonas gingivalis vs. ligature-induced periodontal bone loss. Braz Oral Res. 2017 Aug 21; 31:e63. PMID: 28832712.
    Citations: 6     Fields:    Translation:AnimalsCells
  9. Wang Y, Yu X, Lin J, Hu Y, Zhao Q, Kawai T, Taubman MA, Han X. B10 Cells Alleviate Periodontal Bone Loss in Experimental Periodontitis. Infect Immun. 2017 09; 85(9). PMID: 28652308.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Hu Y, Yu P, Yu X, Hu X, Kawai T, Han X. IL-21/anti-Tim1/CD40 ligand promotes B10 activity in vitro and alleviates bone loss in experimental periodontitis in vivo. Biochim Biophys Acta Mol Basis Dis. 2017 09; 1863(9):2149-2157. PMID: 28583714.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Zhuang Z, Xie N, Hu J, Yu P, Wang C, Hu X, Han X, Hou J, Huang H, Liu X. Interplay between ?Np63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma. Oncotarget. 2017 Mar 28; 8(13):21954-21973. PMID: 28423539.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  12. Shi J, Liu Z, Kawai T, Zhou Y, Han X. Antibiotic administration alleviates the aggravating effect of orthodontic force on ligature-induced experimental periodontitis bone loss in mice. J Periodontal Res. 2017 Aug; 52(4):725-733. PMID: 28213930.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Wisitrasameewong W, Kajiya M, Movila A, Rittling S, Ishii T, Suzuki M, Matsuda S, Mazda Y, Torruella MR, Azuma MM, Egashira K, Freire MO, Sasaki H, Wang CY, Han X, Taubman MA, Kawai T. DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption. J Dent Res. 2017 Jun; 96(6):685-693. PMID: 28199142.
    Citations: 10     Fields:    Translation:AnimalsCells
  14. Kanzaki H, Movila A, Kayal R, Napimoga MH, Egashira K, Dewhirst F, Sasaki H, Howait M, Al-Dharrab A, Mira A, Han X, Taubman MA, Nichols FC, Kawai T. Phosphoglycerol dihydroceramide, a distinctive ceramide produced by Porphyromonas gingivalis, promotes RANKL-induced osteoclastogenesis by acting on non-muscle myosin II-A (Myh9), an osteoclast cell fusion regulatory factor. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May; 1862(5):452-462. PMID: 28153611.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Yu P, Hu Y, Liu Z, Kawai T, Taubman MA, Li W, Han X. Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice. Infect Immun. 2017 Jan; 85(1). PMID: 27795360.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Yu X, Wang Y, Lin J, Hu Y, Kawai T, Taubman MA, Han X. Lipopolysaccharides-Induced Suppression of Innate-Like B Cell Apoptosis Is Enhanced by CpG Oligodeoxynucleotide and Requires Toll-Like Receptors 2 and 4. PLoS One. 2016; 11(11):e0165862. PMID: 27812176.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Kanzaki H, Makihira S, Suzuki M, Ishii T, Movila A, Hirschfeld J, Mawardi H, Lin X, Han X, Taubman MA, Kawai T. Soluble RANKL Cleaved from Activated Lymphocytes by TNF-a-Converting Enzyme Contributes to Osteoclastogenesis in Periodontitis. J Immunol. 2016 11 15; 197(10):3871-3883. PMID: 27815441.
    Citations: 9     Fields:    Translation:HumansCells
  18. Nishimura K, Shindo S, Movila A, Kayal R, Abdullah A, Savitri IJ, Ikeda A, Yamaguchi T, Howait M, Al-Dharrab A, Mira A, Han X, Kawai T. TRAP-positive osteoclast precursors mediate ROS/NO-dependent bactericidal activity via TLR4. Free Radic Biol Med. 2016 08; 97:330-341. PMID: 27343691.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Chen W, Gao B, Hao L, Zhu G, Jules J, MacDougall MJ, Wang J, Han X, Zhou X, Li YP. The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation. J Periodontal Res. 2016 Oct; 51(5):647-60. PMID: 26754272.
    Citations: 9     Fields:    Translation:AnimalsCells
  20. Lin M, Wang Z, Han X. B Cells with Regulatory Function in Animal Models of Autoimmune and Non-Autoimmune Diseases. Open J Immunol. 2015 Mar; 5(1):9-17. PMID: 26236565.
    Citations: 3     
  21. Lin M, Lin J, Wang Y, Bonheur N, Kawai T, Wang Z, Han X. Lipopolysaccharide Attenuates CD40 Ligand-Induced Regulatory B10 Cell Expansion and IL-10 Production in Mouse Splenocytes. Open J Immunol. 2015 Mar; 5(1):1-8. PMID: 26236564.
    Citations: 3     
  22. Wang Y, Han X. B Cells with Regulatory Function in Human Diseases. Autoimmune Dis Ther Approaches. 2014; 1(2). PMID: 26973880.
    Citations: 1     
  23. Lin J, Bi L, Yu X, Kawai T, Taubman MA, Shen B, Han X. Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4. Infect Immun. 2014 Oct; 82(10):4127-34. PMID: 25047844.
    Citations: 38     Fields:    Translation:AnimalsCells
  24. Han X, LaRosa KB, Kawai T, Taubman MA. DNA-based adaptive immunity protect host from infection-associated periodontal bone resorption via recognition of Porphyromonas gingivalis virulence component. Vaccine. 2014 Jan 03; 32(2):297-303. PMID: 24051159.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Han X, Lin X, Yu X, Lin J, Kawai T, LaRosa KB, Taubman MA. Porphyromonas gingivalis infection-associated periodontal bone resorption is dependent on receptor activator of NF-?B ligand. Infect Immun. 2013 May; 81(5):1502-9. PMID: 23439308.
    Citations: 23     Fields:    Translation:AnimalsCells
  26. Jin JO, Han X, Yu Q. Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation. J Autoimmun. 2013 Feb; 40:28-44. PMID: 22921334.
    Citations: 41     Fields:    Translation:AnimalsCells
  27. Branco-de-Almeida LS, Kajiya M, Cardoso CR, Silva MJ, Ohta K, Rosalen PL, Franco GC, Han X, Taubman MA, Kawai T. Selective serotonin reuptake inhibitors attenuate the antigen presentation from dendritic cells to effector T lymphocytes. FEMS Immunol Med Microbiol. 2011 Aug; 62(3):283-94. PMID: 21569123.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Lin X, Han X, Kawai T, Taubman MA. Antibody to receptor activator of NF-?B ligand ameliorates T cell-mediated periodontal bone resorption. Infect Immun. 2011 Feb; 79(2):911-7. PMID: 21078845.
    Citations: 27     Fields:    Translation:AnimalsCells
  29. Kajiya M, Giro G, Taubman MA, Han X, Mayer MP, Kawai T. Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease. J Oral Microbiol. 2010 Nov 08; 2. PMID: 21523224.
    Citations: 29     
  30. Han X, Lin X, Seliger AR, Eastcott J, Kawai T, Taubman MA. Expression of receptor activator of nuclear factor-kappaB ligand by B cells in response to oral bacteria. Oral Microbiol Immunol. 2009 Jun; 24(3):190-6. PMID: 19416447.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  31. Taubman MA, Han X, Larosa KB, Socransky SS, Smith DJ. Periodontal bacterial DNA suppresses the immune response to mutans streptococcal glucosyltransferase. Infect Immun. 2007 Aug; 75(8):4088-96. PMID: 17517867.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Taubman MA, Kawai T, Han X. The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies. J Clin Periodontol. 2007 May; 34(5):367-9. PMID: 17448041.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  33. Han X, Kawai T, Taubman MA. Interference with immune-cell-mediated bone resorption in periodontal disease. Periodontol 2000. 2007; 45:76-94. PMID: 17850450.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  34. Culshaw S, Larosa K, Tolani H, Han X, Eastcott JW, Smith DJ, Taubman MA. Immunogenic and protective potential of mutans streptococcal glucosyltransferase peptide constructs selected by major histocompatibility complex class II allele binding. Infect Immun. 2007 Feb; 75(2):915-23. PMID: 17088351.
    Citations: 6     Fields:    Translation:AnimalsCells
  35. Harada Y, Han X, Yamashita K, Kawai T, Eastcott JW, Smith DJ, Taubman MA. Effect of adoptive transfer of antigen-specific B cells on periodontal bone resorption. J Periodontal Res. 2006 Apr; 41(2):101-7. PMID: 16499712.
    Citations: 11     Fields:    Translation:AnimalsCells
  36. Han X, Kawai T, Eastcott JW, Taubman MA. Bacterial-responsive B lymphocytes induce periodontal bone resorption. J Immunol. 2006 Jan 01; 176(1):625-31. PMID: 16365458.
    Citations: 42     Fields:    Translation:AnimalsCells
  37. Taubman MA, Valverde P, Han X, Kawai T. Immune response: the key to bone resorption in periodontal disease. J Periodontol. 2005 Nov; 76(11 Suppl):2033-41. PMID: 16277573.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
  38. Taubman MA, Valverde P, Han X, Kawai T. Immune Response: The Key to Bone Resorption in Periodontal Disease. J Periodontol. 2005 Nov; 76 Suppl 11S:2033-2041. PMID: 29539039.
    Citations: 1     Fields:    
  39. Amar S, Han X. The impact of periodontal infection on systemic diseases. Med Sci Monit. 2003 Dec; 9(12):RA291-9. PMID: 14646984.
    Citations: 27     Fields:    Translation:Humans
  40. Han X, Amar S. Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. J Biol Chem. 2004 Jan 23; 279(4):2832-40. PMID: 14581477.
    Citations: 15     Fields:    Translation:HumansCells
  41. Han X, Amar S. Role of insulin-like growth factor-1 signaling in dental fibroblast apoptosis. J Periodontol. 2003 Aug; 74(8):1176-82. PMID: 14514231.
    Citations: 1     Fields:    Translation:HumansCells
  42. Han X, Amar S. IGF-1 signaling enhances cell survival in periodontal ligament fibroblasts vs. gingival fibroblasts. J Dent Res. 2003 Jun; 82(6):454-9. PMID: 12766198.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  43. Han X, Amar S. Identification of genes differentially expressed in cultured human periodontal ligament fibroblasts vs. human gingival fibroblasts by DNA microarray analysis. J Dent Res. 2002 Jun; 81(6):399-405. PMID: 12097432.
    Citations: 13     Fields:    Translation:HumansCells
  44. Han X, Bolcato AL, Amar S. Identification of genes differentially expressed in cultured human osteoblasts versus human fibroblasts by DNA microarray analysis. Connect Tissue Res. 2002; 43(1):63-75. PMID: 12180269.
    Citations: 4     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Han's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (250)
Co-Authors (5)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.