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Biju Parekkadan, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI134116 (PAREKKADAN, BIJU) May 14, 2018 - Apr 30, 2020
    Theranostic approach to transplant rejection using engineered cell biosensors
    Role: Principal Investigator
  2. R43DK093285 (TILLES, ARNO W) Apr 1, 2012 - Mar 31, 2014
    Cellular Device for the Treatment of Acute Liver Failure
    Role: Principal Investigator
  3. R01EB012521 (PAREKKADAN, BIJU) Aug 1, 2011 - Jul 31, 2017
    Artificial, Humanized Stem Cell Niches
    Role: Principal Investigator
  4. R44DK085766 (TILLES, ARNO W) Jun 15, 2010 - Jul 31, 2017
    Transforming Dialysis into a Controlled Drug Delivery System for Stem Cell Derive
    Role: Co-Principal Investigator
  5. K01DK087770 (PAREKKADAN, BIJU) Apr 1, 2010 - Mar 31, 2015
    Peripheral Tissue Antigen Display by Mesenchymal Stem Cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Knoblich K, Cruz Migoni S, Siew SM, Jinks E, Kaul B, Jeffery HC, Baker AT, Suliman M, Vrzalikova K, Mehenna H, Murray PG, Barone F, Oo YH, Newsome PN, Hirschfield G, Kelly D, Lee SP, Parekkadan B, Turley SJ, Fletcher AL. The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation. PLoS Biol. 2018 Sep; 16(9):e2005046. PMID: 30180168.
    View in: PubMed
  2. Miller BLK, Garg P, Bronstein B, LaPointe E, Lin H, Charytan DM, Tilles AW, Parekkadan B. Extracorporeal Stromal Cell Therapy for Subjects With Dialysis-Dependent Acute Kidney Injury. Kidney Int Rep. 2018 Sep; 3(5):1119-1127. PMID: 30197978.
    View in: PubMed
  3. Li M, Khong D, Chin LY, Singleton A, Parekkadan B. Therapeutic Delivery Specifications Identified Through Compartmental Analysis of a Mesenchymal Stromal Cell-Immune Reaction. Sci Rep. 2018 May 01; 8(1):6816. PMID: 29717209.
    View in: PubMed
  4. Khong D, Li M, Singleton A, Chin LY, Parekkadan B. Stromalized microreactor supports murine hematopoietic progenitor enrichment. Biomed Microdevices. 2018 01 20; 20(1):13. PMID: 29353324.
    View in: PubMed
  5. Mukundan S, Guan D, Singleton A, Yang Y, Li M, Parekkadan B. Artificial T Cell Mimetics to Combat Melanoma Tumor Growth. Am J Adv Drug Deliv. 2018; 6(1):21-32. PMID: 30197907.
    View in: PubMed
  6. Mukundan S, Sharma K, Honselmann K, Singleton A, Liss A, Parekkadan B. Image-Based Profiling of Patient-Derived Pancreatic Tumor-Stromal Cell Interactions Within a Micropatterned Tumor Model. Technol Cancer Res Treat. 2018 Jan 01; 17:1533033818803632. PMID: 30348057.
    View in: PubMed
  7. Khong D, Li M, Singleton A, Chin LY, Mukundan S, Parekkadan B. Orthogonal potency analysis of mesenchymal stromal cell function during ex vivo expansion. Exp Cell Res. 2018 01 01; 362(1):102-110. PMID: 29137914.
    View in: PubMed
  8. Singleton A, Khong D, Chin LY, Mukundan S, Li M, Parekkadan B. An engineered biomarker system to monitor and modulate immune clearance of cell therapies. Cytotherapy. 2017 12; 19(12):1537-1545. PMID: 28917628.
    View in: PubMed
  9. Tosi L, Sridhara V, Yang Y, Guan D, Shpilker P, Segata N, Larman HB, Parekkadan B. Long-adapter single-strand oligonucleotide probes for the massively multiplexed cloning of kilobase genome regions. Nat Biomed Eng. 2017; 1. PMID: 29152409.
    View in: PubMed
  10. Lee J, Heckl D, Parekkadan B. Multiple genetically engineered humanized microenvironments in a single mouse. Biomater Res. 2016; 20:19. PMID: 27354920; PMCID: PMC4924259.
  11. Shen K, Luk S, Elman J, Murray R, Mukundan S, Parekkadan B. Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis. Sci Rep. 2016 Feb 19; 6:21239. PMID: 26893143; PMCID: PMC4759812.
  12. Lee J, Kohl N, Shanbhang S, Parekkadan B. Scaffold-integrated microchips for end-to-end in vitro tumor cell attachment and xenograft formation. Technology (Singap World Sci). 2015 Dec; 3(4):179-188. PMID: 26709385.
    View in: PubMed
  13. Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B. Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun. 2014 Dec 09; 5:5662. PMID: 25489927; PMCID: PMC4261930.
  14. Bersani F, Lee J, Yu M, Morris R, Desai R, Ramaswamy S, Toner M, Haber DA, Parekkadan B. Bioengineered implantable scaffolds as a tool to study stromal-derived factors in metastatic cancer models. Cancer Res. 2014 Dec 15; 74(24):7229-38. PMID: 25339351; PMCID: PMC4267901.
  15. Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B. Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis. Sci Transl Med. 2014 Aug 13; 6(249):249ra109. PMID: 25122637; PMCID: PMC4415170.
  16. Shen K, Lee J, Yarmush ML, Parekkadan B. Microcavity substrates casted from self-assembled microsphere monolayers for spheroid cell culture. Biomed Microdevices. 2014 Aug; 16(4):609-15. PMID: 24781882; PMCID: PMC4415162.
  17. Patel SJ, Milwid JM, King KR, Bohr S, Iracheta-Velle A, Li M, Vitalo A, Parekkadan B, Jindal R, Yarmush ML. Erratum: Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. Nat Biotechnol. 2014 Mar 10; 32(3):291. PMID: 24727782.
    View in: PubMed
  18. Elman JS, Murray RC, Murray RM, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B. Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells. PLoS One. 2014; 9(2):e89882. PMID: 24587097; PMCID: PMC3931832.
  19. Milwid JM, Elman JS, Li M, Shen K, Manrai A, Gabow A, Yarmush J, Jiao Y, Fletcher A, Lee J, Cima MJ, Yarmush ML, Parekkadan B. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther. 2014 May; 22(5):999-1007. PMID: 24496384; PMCID: PMC4017089.
  20. Elman JS, Li M, Wang F, Gimble JM, Parekkadan B. A comparison of adipose and bone marrow-derived mesenchymal stromal cell secreted factors in the treatment of systemic inflammation. J Inflamm (Lond). 2014 Jan 07; 11(1):1. PMID: 24397734; PMCID: PMC3895743.
  21. Lee J, Wang JB, Bersani F, Parekkadan B. Capture and printing of fixed stromal cell membranes for bioactive display on PDMS surfaces. Langmuir. 2013 Aug 27; 29(34):10611-6. PMID: 23927769; PMCID: PMC3789619.
  22. Milwid JM, Ichimura T, Li M, Jiao Y, Lee J, Yarmush JS, Parekkadan B, Tilles AW, Bonventre JV, Yarmush ML. Secreted factors from bone marrow stromal cells upregulate IL-10 and reverse acute kidney injury. Stem Cells Int. 2012; 2012:392050. PMID: 23319959; PMCID: PMC3539665.
  23. Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B. Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19638-43. PMID: 23150542; PMCID: PMC3511730.
  24. Patel SJ, Milwid JM, King KR, Bohr S, Iracheta-Vellve A, Iracheta-Velle A, Li M, Vitalo A, Parekkadan B, Jindal R, Yarmush ML. Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. Nat Biotechnol. 2012 Jan 15; 30(2):179-83. PMID: 22252509; PMCID: PMC3609650.
  25. Parekkadan B, Fletcher AL, Li M, Tjota MY, Bellemare-Pelletier A, Milwid JM, Lee JW, Yarmush ML, Turley SJ. Aire controls mesenchymal stem cell-mediated suppression in chronic colitis. Mol Ther. 2012 Jan; 20(1):178-86. PMID: 21952165; PMCID: PMC3255580.
  26. Li M, Tilles AW, Milwid JM, Hammad M, Lee J, Yarmush ML, Parekkadan B. Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors. J Tissue Eng Regen Med. 2012 May; 6(5):369-77. PMID: 21710576; PMCID: PMC3183117.
  27. Jiao J, Milwid JM, Yarmush ML, Parekkadan B. A mesenchymal stem cell potency assay. Methods Mol Biol. 2011; 677:221-31. PMID: 20941614; PMCID: PMC3759509.
  28. Parekkadan B, Upadhyay R, Dunham J, Iwamoto Y, Mizoguchi E, Mizoguchi A, Weissleder R, Yarmush ML. Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes. Gastroenterology. 2011 Mar; 140(3):966-75. PMID: 20955701; PMCID: PMC3033974.
  29. Parekkadan B, Milwid JM. Mesenchymal stem cells as therapeutics. Annu Rev Biomed Eng. 2010 Aug 15; 12:87-117. PMID: 20415588; PMCID: PMC3759519.
  30. Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML. Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1. Mol Ther. 2010 Oct; 18(10):1857-64. PMID: 20664529; PMCID: PMC2951565.
  31. Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML. Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplant. 2010; 19(6):667-79. PMID: 20525442; PMCID: PMC2957533.
  32. Yagi H, Parekkadan B, Suganuma K, Soto-Gutierrez A, Tompkins RG, Tilles AW, Yarmush ML. Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure. Tissue Eng Part A. 2009 Nov; 15(11):3377-88. PMID: 19397469; PMCID: PMC2792056.
  33. van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology. 2008 May; 47(5):1634-43. PMID: 18395843.
    View in: PubMed
  34. Parekkadan B, Tilles AW, Yarmush ML. Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. Stem Cells. 2008 Jul; 26(7):1913-9. PMID: 18420833.
    View in: PubMed
  35. Parekkadan B, Berdichevsky Y, Irimia D, Leeder A, Yarmush G, Toner M, Levine JB, Yarmush ML. Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells. Neurosci Lett. 2008 Jun 20; 438(2):190-5. PMID: 18467031; PMCID: PMC2448393.
  36. Levine JB, Leeder AD, Parekkadan B, Berdichevsky Y, Rauch SL, Smoller JW, Konradi C, Berthiaume F, Yarmush ML. Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats. Neuroscience. 2008 Jan 24; 151(2):589-603. PMID: 18063315; PMCID: PMC3923447.
  37. Parekkadan B, Sethu P, van Poll D, Yarmush ML, Toner M. Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood. Tissue Eng. 2007 Oct; 13(10):2465-73. PMID: 17665999.
    View in: PubMed
  38. Parekkadan B, van Poll D, Suganuma K, Carter EA, Berthiaume F, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One. 2007 Sep 26; 2(9):e941. PMID: 17895982; PMCID: PMC1978513.
  39. Parekkadan B, van Poll D, Megeed Z, Kobayashi N, Tilles AW, Berthiaume F, Yarmush ML. Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun. 2007 Nov 16; 363(2):247-52. PMID: 17869217; PMCID: PMC2096777.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.