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Vijay Kumar Kuchroo, Ph.D.

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Mentoring
Th1-specific T Cell Immunoglobulin and Mucin-domain-containing molecule (Tim) family genes in autoimmunity
Summer, 06/01/02 - 08/31/02
Phenotypic Characterization of Putative Helper T Cell Subset Induced by Innate Cytokine Milieu
Summer, 06/14/10 - 08/06/10
Induction of T regulatory type 1-like phenotype in CD4+ T cells by interleukin-27 and interferon-á
Summer, 06/21/10 - 08/14/10

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI139536 (KUCHROO, VIJAY K.) Jul 1, 2018 - Jun 30, 2023
    NIH/NIAID
    Neuroimmune interactions regulate development of allergic inflammation
    Role: Principal Investigator
  2. RC2DK114784 (XAVIER, RAMNIK J) Aug 1, 2017 - Jul 31, 2022
    NIH/NIDDK
    Systematic dissection of gut cellular circuits [at single cell resolution]
    Role: Co-Principal Investigator
  3. R01DK096138 (KUCHROO, VIJAY K.) May 1, 2013 - Apr 30, 2017
    NIH/NIDDK
    Role of Tim-4 in Regulating Type 1 Diabetes
    Role: Principal Investigator
  4. P01NS076410 (WEINER, HOWARD L) Dec 1, 2012 - Nov 30, 2017
    NIH/NINDS
    Transcriptional Control of Autoimmunity in the Central Nervous System
    Role: Co-Principal Investigator
  5. R56AI044880 (KUCHROO, VIJAY K.) Sep 1, 2011 - Aug 31, 2012
    NIH/NIAID
    Genetic basis for susceptibility to EAE
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
BWH-BRI Antibody Core Facility - Antibodies (18) and Core services (1)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chihara N, Madi A, Kondo T, Zhang H, Acharya N, Singer M, Nyman J, Marjanovic ND, Kowalczyk MS, Wang C, Kurtulus S, Law T, Etminan Y, Nevin J, Buckley CD, Burkett PR, Buenrostro JD, Rozenblatt-Rosen O, Anderson AC, Regev A, Kuchroo VK. Induction and transcriptional regulation of the co-inhibitory gene module in T cells. Nature. 2018 Jun; 558(7710):454-459. PMID: 29899446.
    View in: PubMed
  2. Meyer Zu Horste G, Przybylski D, Schramm MA, Wang C, Schnell A, Lee Y, Sobel R, Regev A, Kuchroo VK. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity. 2018 Mar 20; 48(3):556-569.e7. PMID: 29562202.
    View in: PubMed
  3. Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH. Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol. 2018 Apr 15; 200(8):2592-2602. PMID: 29531164.
    View in: PubMed
  4. Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N. Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. J Immunol. 2018 Apr 15; 200(8):3000-3007. PMID: 29500245.
    View in: PubMed
  5. Wu C, Chen Z, Xiao S, Thalhamer T, Madi A, Han T, Kuchroo V. SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells. Cell Rep. 2018 Jan 16; 22(3):653-665. PMID: 29346764.
    View in: PubMed
  6. Nakashima H, Alayo QA, Penaloza-MacMaster P, Freeman GJ, Kuchroo VK, Reardon DA, Fernandez S, Caligiuri M, Chiocca EA. Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018 Jan 09; 8(1):208. PMID: 29317703.
    View in: PubMed
  7. Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL. Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nat Commun. 2017 11 17; 8(1):1600. PMID: 29150604.
    View in: PubMed
  8. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 09 21; 549(7672):351-356. PMID: 28902842.
    View in: PubMed
  9. Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL. Targeting latency-associated peptide promotes antitumor immunity. Sci Immunol. 2017 May 19; 2(11). PMID: 28763794.
    View in: PubMed
  10. Das M, Zhu C, Kuchroo VK. Tim-3 and its role in regulating anti-tumor immunity. Immunol Rev. 2017 03; 276(1):97-111. PMID: 28258697.
    View in: PubMed
  11. Wu C, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, Madi A, Franca RF, Han T, Oukka M, Kuchroo V. The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program. Nat Immunol. 2017 03; 18(3):344-353. PMID: 28114290.
    View in: PubMed
  12. Burkett PR, Kuchroo VK. IL-17 Blockade in Psoriasis. Cell. 2016 Dec 15; 167(7):1669. PMID: 27984714.
    View in: PubMed
  13. Kishi Y, Kondo T, Xiao S, Yosef N, Gaublomme J, Wu C, Wang C, Chihara N, Regev A, Joller N, Kuchroo VK. Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity. J Exp Med. 2016 10 17; 213(11):2489-2501. PMID: 27670590.
    View in: PubMed
  14. Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66. PMID: 27551155.
    View in: PubMed
  15. Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK. RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell Rep. 2016 07 12; 16(2):392-404. PMID: 27346359; PMCID: PMC4984261.
  16. Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7596-601. PMID: 27313209; PMCID: PMC4941458 [Available on 01/05/17].
  17. Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. Immunity. 2016 05 17; 44(5):989-1004. PMID: 27192565; PMCID: PMC4942846 [Available on 05/17/17].
  18. Chihara N, Madi A, Karwacz K, Awasthi A, Kuchroo VK. Differentiation and Characterization of Tr1 Cells. Curr Protoc Immunol. 2016 Apr 01; 113:3.27.1-3.27.10. PMID: 27038462.
    View in: PubMed
  19. Jayaraman P, Jacques MK, Zhu C, Steblenko KM, Stowell BL, Madi A, Anderson AC, Kuchroo VK, Behar SM. TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection. PLoS Pathog. 2016 Mar; 12(3):e1005490. PMID: 26967901; PMCID: PMC4788425.
  20. Patel DD, Kuchroo VK. Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions. Immunity. 2015 Dec 15; 43(6):1040-51. PMID: 26682981.
    View in: PubMed
  21. Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK. CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell. 2015 Dec 03; 163(6):1413-27. PMID: 26607793; PMCID: PMC4671820 [Available on 12/03/16].
  22. Gaublomme JT, Yosef N, Lee Y, Gertner RS, Yang LV, Wu C, Pandolfi PP, Mak T, Satija R, Shalek AK, Kuchroo VK, Park H, Regev A. Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Cell. 2015 Dec 03; 163(6):1400-12. PMID: 26607794.
    View in: PubMed
  23. Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. J Clin Invest. 2015 Nov 02; 125(11):4212-22. PMID: 26524592; PMCID: PMC4639983.
  24. Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin D. Oct1 and OCA-B are selectively required for CD4 memory T cell function. J Exp Med. 2015 Nov 16; 212(12):2115-31. PMID: 26481684; PMCID: PMC4647264.
  25. Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015 Nov 15; 195(10):4841-52. PMID: 26438525.
    View in: PubMed
  26. Kurtulus S, Sakuishi K, Ngiow SF, Joller N, Tan DJ, Teng MW, Smyth MJ, Kuchroo VK, Anderson AC. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest. 2015 Nov 02; 125(11):4053-62. PMID: 26413872; PMCID: PMC4639980.
  27. Lee Y, Mitsdoerffer M, Xiao S, Gu G, Sobel RA, Kuchroo VK. IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Nov 02; 125(11):4011-20. PMID: 26413871; PMCID: PMC4639966.
  28. Peters A, Fowler KD, Chalmin F, Merkler D, Kuchroo VK, Pot C. IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling. J Immunol. 2015 Nov 01; 195(9):4144-53. PMID: 26408664; PMCID: PMC4610870 [Available on 11/01/16].
  29. Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21; 212(10):1603-21. PMID: 26371185; PMCID: PMC4577848.
  30. Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015 Sep 10; 162(6):1338-52. PMID: 26359987; PMCID: PMC4570563.
  31. Wang C, Collins M, Kuchroo VK. Effector T cell differentiation: are master regulators of effector T cells still the masters? Curr Opin Immunol. 2015 Dec; 37:6-10. PMID: 26319196.
    View in: PubMed
  32. Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015 Jul 08; 6:7657. PMID: 26153760.
    View in: PubMed
  33. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54. PMID: 26119026; PMCID: PMC4506220.
  34. Andersson KM, Cavallini NF, Hu D, Brisslert M, Cialic R, Valadi H, Erlandsson MC, Silfverswärd S, Pullerits R, Kuchroo VK, Weiner HL, Bokarewa MI. Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment. Mol Med. 2015 Jun 04; 21:536-43. PMID: 26062018.
    View in: PubMed
  35. Lee Y, Kuchroo V. Defining the functional states of Th17 cells. F1000Res. 2015; 4(F1000 Faculty Rev):132. PMID: 27006754; PMCID: PMC4797958.
  36. Burkett PR, Meyer zu Horste G, Kuchroo VK. Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. J Clin Invest. 2015 Jun; 125(6):2211-9. PMID: 25961452; PMCID: PMC4497747.
  37. Dardalhon V, Collins M, Kuchroo VK. Physical attraction of Th9 cells is skin deep. Ann Transl Med. 2015 Apr; 3(6):74. PMID: 25992373; PMCID: PMC4416954.
  38. Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 2015 Apr; 125(4):1620-36. PMID: 25751064; PMCID: PMC4396492.
  39. Anderson AC, Sullivan JM, Tan DJ, Lee DH, Kuchroo VK. A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation. J Autoimmun. 2015 May; 59:38-42. PMID: 25725581; PMCID: PMC4414806.
  40. Wu C, Chen Z, Kuchroo VK. Ezh2 lines up the chromatin in T regulatory cells. Immunity. 2015 Feb 17; 42(2):201-203. PMID: 25692693.
    View in: PubMed
  41. Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM. TIM-1 signaling is required for maintenance and induction of regulatory B cells. Am J Transplant. 2015 Apr; 15(4):942-53. PMID: 25645598; PMCID: PMC4530122.
  42. Wu C, Chen Z, Kuchroo VK. DUBA-UBR5 axis: other than transactivation. Cell Res. 2015 Mar; 25(3):273-4. PMID: 25633593; PMCID: PMC4349248.
  43. Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015 Jan 23; 6:6072. PMID: 25614966; PMCID: PMC4311884.
  44. Xiao S, Brooks CR, Sobel RA, Kuchroo VK. Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation. J Immunol. 2015 Feb 15; 194(4):1602-8. PMID: 25582854; PMCID: PMC4346345.
  45. Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour RE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN, Levy BD. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol. 2015 Feb 01; 194(3):863-7. PMID: 25539814; PMCID: PMC4297713.
  46. Peters A, Burkett PR, Sobel RA, Buckley CD, Watson SP, Bettelli E, Kuchroo VK. Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest. 2015 Jan; 125(1):129-40. PMID: 25415436.
    View in: PubMed
  47. Liu Y, Ji H, Zhang Y, Shen X, Gao F, He X, Li GA, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JW. Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury. J Hepatol. 2015 Mar; 62(3):563-72. PMID: 25450716; PMCID: PMC4336640.
  48. Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015 Feb 19; 518(7539):337-43. PMID: 25363779.
    View in: PubMed
  49. Ji H, Liu Y, Zhang Y, Shen XD, Gao F, Busuttil RW, Kuchroo VK, Kupiec-Weglinski JW. T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury. Hepatology. 2014 Dec; 60(6):2052-2064. PMID: 25066922; PMCID: PMC4396987.
  50. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015 01 15; 517(7534):386-90. PMID: 25363763; PMCID: PMC4297519.
  51. Kuchroo VK, Anderson AC, Petrovas C. Coinhibitory receptors and CD8 T cell exhaustion in chronic infections. Curr Opin HIV AIDS. 2014 Sep; 9(5):439-45. PMID: 25010894.
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  52. Quiniou C, Domínguez-Punaro M, Cloutier F, Erfani A, Ennaciri J, Sivanesan D, Sanchez M, Chognard G, Hou X, Rivera JC, Beauchamp C, Charron G, Vilquin M, Kuchroo V, Michnick S, Rioux JD, Lesage S, Chemtob S. Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response. Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15; 307(10):R1216-30. PMID: 25354400.
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  53. Speck S, Lim J, Shelake S, Matka M, Stoddard J, Farr A, Kuchroo V, Laouar Y. TGF-ß signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation. PLoS One. 2014; 9(7):e102390. PMID: 25072375; PMCID: PMC4114567.
  54. Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, Kuchroo VK. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity. 2014 Aug 21; 41(2):270-82. PMID: 25065622; PMCID: PMC4219323.
  55. Kuchroo VK, Anderson AC, Freeman GJ. Comment on "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection". J Immunol. 2014 Jul 15; 193(2):467. PMID: 24994907.
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  56. Thornley TB, Fang Z, Balasubramanian S, Larocca RA, Gong W, Gupta S, Csizmadia E, Degauque N, Kim BS, Koulmanda M, Kuchroo VK, Strom TB. Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory. J Clin Invest. 2014 Aug; 124(8):3443-54. PMID: 24983317; PMCID: PMC4109530.
  57. Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest. 2014 Jun; 124(6):2513-22. PMID: 24812667; PMCID: PMC4089462.
  58. Lee Y, Collins M, Kuchroo VK. Unexpected targets and triggers of autoimmunity. J Clin Immunol. 2014 Jul; 34 Suppl 1:S56-60. PMID: 24789684; PMCID: PMC4083752.
  59. Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17; 40(4):569-81. PMID: 24745333; PMCID: PMC4070748.
  60. Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small-molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17; 40(4):477-89. PMID: 24745332; PMCID: PMC4066874.
  61. Czuczman MA, Fattouh R, van Rijn JM, Canadien V, Osborne S, Muise AM, Kuchroo VK, Higgins DE, Brumell JH. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 2014 May 08; 509(7499):230-4. PMID: 24739967.
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  62. Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, Constantin G. TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity. 2014 Apr 17; 40(4):542-53. PMID: 24703780; PMCID: PMC4066214.
  63. Clarkson BD, Ling C, Shi Y, Harris MG, Rayasam A, Sun D, Salamat MS, Kuchroo V, Lambris JD, Sandor M, Fabry Z. T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice. J Exp Med. 2014 Apr 07; 211(4):595-604. PMID: 24616379; PMCID: PMC3978271.
  64. Chognard G, Bellemare L, Pelletier AN, Dominguez-Punaro MC, Beauchamp C, Guyon MJ, Charron G, Morin N, Sivanesan D, Kuchroo V, Xavier R, Michnick SW, Chemtob S, Rioux JD, Lesage S. The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation. PLoS One. 2014; 9(2):e89092. PMID: 24586521; PMCID: PMC3931659.
  65. da Silva IP, Gallois A, Jimenez-Baranda S, Khan S, Anderson AC, Kuchroo VK, Osman I, Bhardwaj N. Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade. Cancer Immunol Res. 2014 May; 2(5):410-22. PMID: 24795354; PMCID: PMC4046278.
  66. Vega-Carrascal I, Bergin DA, McElvaney OJ, McCarthy C, Banville N, Pohl K, Hirashima M, Kuchroo VK, Reeves EP, McElvaney NG. Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung. J Immunol. 2014 Mar 01; 192(5):2418-31. PMID: 24477913; PMCID: PMC4997615.
  67. Joller N, Kuchroo VK. Good guys gone bad: exTreg cells promote autoimmune arthritis. Nat Med. 2014 Jan; 20(1):15-7. PMID: 24398957.
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  68. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Corrigendum: Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2013 Dec 18; 15(1):109. PMID: 24352327.
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  69. Fourcade J, Sun Z, Pagliano O, Chauvin JM, Sander C, Janjic B, Tarhini AA, Tawbi HA, Kirkwood JM, Moschos S, Wang H, Guillaume P, Luescher IF, Krieg A, Anderson AC, Kuchroo VK, Zarour HM. PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8? T cells induced by melanoma vaccines. Cancer Res. 2014 Feb 15; 74(4):1045-55. PMID: 24343228; PMCID: PMC3952491.
  70. Pot C, Quintana FJ, Kuchroo VK. Fine tuning of the immune response by the Aryl Hydrocarbon Receptor. Semin Immunopathol. 2013 Nov; 35(6):613. PMID: 24104867.
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  76. Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC, Ozato K, Sikora AG, Xiong H. T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med. 2013 Jul 01; 210(7):1447-62. PMID: 23797094; PMCID: PMC3698516.
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  83. Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ. IL-21 promotes CD8+ CTL activity via the transcription factor T-bet. J Immunol. 2013 Apr 15; 190(8):3977-84. PMID: 23479229.
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  84. Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. Dynamic regulatory network controlling TH17 cell differentiation. Nature. 2013 Apr 25; 496(7446):461-8. PMID: 23467089; PMCID: PMC3637864.
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  86. Ichinose K, Zhang Z, Koga T, Juang YT, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, Tsokos GC. Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum. 2013 Mar; 65(3):764-9. PMID: 23203389; PMCID: PMC3582760.
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  88. Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Sci Signal. 2012 Dec 11; 5(254):ra90. PMID: 23233528; PMCID: PMC3767312.
  89. Wang C, Wu L, Bulek K, Martin BN, Zepp JA, Kang Z, Liu C, Herjan T, Misra S, Carman JA, Gao J, Dongre A, Han S, Bunting KD, Ko JS, Xiao H, Kuchroo VK, Ouyang W, Li X. The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 2013 Jan; 14(1):72-81. PMID: 23202271.
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  93. Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24; 37(2):276-89. PMID: 22884313.
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  95. Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med. 2012 Aug; 18(8):1248-53. PMID: 22772464.
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  99. Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest. 2012 Jul; 122(7):2395-404. PMID: 22684103; PMCID: PMC3386804.
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  102. Fowler KD, Kuchroo VK, Chakraborty AK. A model for how signal duration can determine distinct outcomes of gene transcription programs. PLoS One. 2012; 7(3):e33018. PMID: 22427931; PMCID: PMC3302786.
  103. Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012 Apr 01; 188(7):3127-37. PMID: 22345665; PMCID: PMC3311782.
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  108. Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol. 2012 Jan 01; 188(1):155-62. PMID: 22124121.
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  109. Ambrosi A, Dzikaite V, Park J, Strandberg L, Kuchroo VK, Herlenius E, Wahren-Herlenius M. Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model. Ann Rheum Dis. 2012 Mar; 71(3):448-54. PMID: 22084395.
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  116. Lee J, Su EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP. Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways. Mol Cell Biol. 2011 Oct; 31(19):3963-74. PMID: 21807895; PMCID: PMC3187355.
  117. Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of TH17 cells occurs in the small intestine. Nature. 2011 Jul 17; 475(7357):514-8. PMID: 21765430.
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  129. Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Kuchroo V, Zarour HM. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med. 2010 Sep 27; 207(10):2175-86. PMID: 20819923; PMCID: PMC2947081.
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  131. Strandberg LS, Ambrosi A, Jagodic M, Dzikaite V, Janson P, Khademi M, Salomonsson S, Ottosson L, Klauninger R, Adén U, Sonesson SE, Sunnerhagen M, de Graaf KL, Kuchroo VK, Achour A, Winqvist O, Olsson T, Wahren-Herlenius M. Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block. J Immunol. 2010 Sep 15; 185(6):3574-82. PMID: 20696861.
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  137. Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 01; 185(1):46-54. PMID: 20498357; PMCID: PMC2936106.
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  149. Awasthi A, Kuchroo VK. Immunology. The yin and yang of follicular helper T cells. Science. 2009 Aug 21; 325(5943):953-5. PMID: 19696339.
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  234. Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 01; 173(3):1689-98. PMID: 15265898.
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  236. Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10691-6. PMID: 15249675; PMCID: PMC489996.
  237. Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med. 2004 Jul 05; 200(1):79-87. PMID: 15238607; PMCID: PMC2213316.
  238. Greve B, Reddy J, Waldner HP, Sobel RA, Kuchroo VK. Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes. Eur J Immunol. 2004 Jul; 34(7):1828-38. PMID: 15214031.
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  239. Greve B, Vijayakrishnan L, Kubal A, Sobel RA, Peterson LB, Wicker LS, Kuchroo VK. The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J Immunol. 2004 Jul 01; 173(1):157-63. PMID: 15210770.
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  240. Ellmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. Eur J Immunol. 2004 Jul; 34(7):1839-48. PMID: 15214032.
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  241. Khademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol. 2004 Jun 01; 172(11):7169-76. PMID: 15153541.
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  242. Hawiger D, Masilamani RF, Bettelli E, Kuchroo VK, Nussenzweig MC. Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity. 2004 Jun; 20(6):695-705. PMID: 15189735.
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  243. Petersen TR, Gülland S, Bettelli E, Kuchroo V, Palmer E, Bäckström BT. A chimeric T cell receptor with super-signaling properties. Int Immunol. 2004 Jul; 16(7):889-94. PMID: 15148288.
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  245. Waldner H, Collins M, Kuchroo VK. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest. 2004 Apr; 113(7):990-7. PMID: 15057305; PMCID: PMC379316.
  246. Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol. 2004 Feb; 16(2):249-56. PMID: 14734610.
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  247. Petersen TR, Bettelli E, Sidney J, Sette A, Kuchroo V, Bäckström BT. Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. Eur J Immunol. 2004 Jan; 34(1):165-73. PMID: 14971042.
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  249. Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov; 4(11):1093-101. PMID: 14556005.
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  251. Robinson WH, Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L. Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Nat Biotechnol. 2003 Sep; 21(9):1033-9. PMID: 12910246.
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  252. Chang TT, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. Eur J Immunol. 2003 Jul; 33(7):2022-2032. PMID: 12884869.
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  255. Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 05; 197(9):1073-81. PMID: 12732654; PMCID: PMC2193967.
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  257. Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK. Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol. 2003 Jan 15; 170(2):870-7. PMID: 12517952.
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  259. Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. J Immunol. 2002 Nov 15; 169(10):5382-6. PMID: 12421909.
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  260. Munder M, Bettelli E, Monney L, Slavik JM, Nicholson LB, Kuchroo VK. Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand. J Exp Med. 2002 Nov 04; 196(9):1151-62. PMID: 12417626; PMCID: PMC2194103.
  261. Howie D, Okamoto S, Rietdijk S, Clarke K, Wang N, Gullo C, Bruggeman JP, Manning S, Coyle AJ, Greenfield E, Kuchroo V, Terhorst C. The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood. 2002 Oct 15; 100(8):2899-907. PMID: 12351401.
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  262. Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. Eur J Immunol. 2002 Sep; 32(9):2687-97. PMID: 12207354.
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  263. Freeman GJ, Sharpe AH, Kuchroo VK. Protect the killer: CTLs need defenses against the tumor. Nat Med. 2002 Aug; 8(8):787-9. PMID: 12152031.
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  264. Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. J Immunol. 2002 May 15; 168(10):5070-8. PMID: 11994459.
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  265. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002 Jan 31; 415(6871):536-41. PMID: 11823861.
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  266. Chang TT, Kuchroo VK, Sharpe AH. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr Dir Autoimmun. 2002; 5:113-30. PMID: 11826754.
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  267. McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001 Dec; 2(12):1109-16. PMID: 11725301.
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  268. Gaglia JL, Mattoo A, Greenfield EA, Freeman GJ, Kuchroo VK. Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation. Cell Immunol. 2001 Nov 01; 213(2):83-93. PMID: 11831870.
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  269. Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, Nicholson LB. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol. 2002; 20:101-23. PMID: 11861599.
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  270. Stremmel C, Exley M, Balk S, Hohenberger W, Kuchroo VK. Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets. Eur J Immunol. 2001 Sep; 31(9):2818-28. PMID: 11536181.
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  271. Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M. Protective autoimmunity is a physiological response to CNS trauma. J Neurosci. 2001 Jun 01; 21(11):3740-8. PMID: 11356861.
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  272. Theien BE, Vanderlugt CL, Eagar TN, Nickerson-Nutter C, Nazareno R, Kuchroo VK, Miller SD. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Apr; 107(8):995-1006. PMID: 11306603; PMCID: PMC199558.
  273. Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol. 2001 Mar; 13(3):257-64. PMID: 11222494.
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  274. Anderson AC, Nicholson LB, Kuchroo VK. The origin and regulation of autopathogenic T cells. J Clin Immunol. 2001 Mar; 21(2):74-80. PMID: 11332656.
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  277. McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 2000 Nov 01; 165(9):5035-40. PMID: 11046032.
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  278. Nicholson LB, Kuchroo VK. Selecting killers: the line between life and death. Nat Immunol. 2000 Sep; 1(3):192-4. PMID: 10973273.
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  279. Anderson AC, Waldner H, Turchin V, Jabs C, Prabhu Das M, Kuchroo VK, Nicholson LB. Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity. Cell Immunol. 2000 Jun 15; 202(2):88-96. PMID: 10896768.
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  280. Young DA, Lowe LD, Booth SS, Whitters MJ, Nicholson L, Kuchroo VK, Collins M. IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J Immunol. 2000 Apr 01; 164(7):3563-72. PMID: 10725711.
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  284. Griffiths MM, Encinas JA, Remmers EF, Kuchroo VK, Wilder RL. Mapping autoimmunity genes. Curr Opin Immunol. 1999 Dec; 11(6):689-700. PMID: 10631556.
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  285. Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med. 1999 Sep 06; 190(5):733-40. PMID: 10477557; PMCID: PMC2195617.
  286. Maron R, Hancock WW, Slavin A, Hattori M, Kuchroo V, Weiner HL. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. Int Immunol. 1999 Sep; 11(9):1573-80. PMID: 10464178.
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  287. Liu L, Kuchroo VK, Weiner HL. B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance. J Immunol. 1999 Aug 15; 163(4):2284-90. PMID: 10438973.
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  288. Stremmel C, Greenfield EA, Howard E, Freeman GJ, Kuchroo VK. B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism. J Exp Med. 1999 Mar 15; 189(6):919-30. PMID: 10075975; PMCID: PMC2193048.
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  294. Carrizosa AM, Nicholson LB, Farzan M, Southwood S, Sette A, Sobel RA, Kuchroo VK. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J Immunol. 1998 Oct 01; 161(7):3307-14. PMID: 9759846.
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  297. Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. J Immunol. 1997 Nov 15; 159(10):4799-805. PMID: 9366404.
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  299. Das MP, Nicholson LB, Greer JM, Kuchroo VK. Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein. J Exp Med. 1997 Sep 15; 186(6):867-76. PMID: 9294141; PMCID: PMC2199041.
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  320. Kuchroo VK, Greer JM, Kaul D, Ishioka G, Franco A, Sette A, Sobel RA, Lees MB. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J Immunol. 1994 Oct 01; 153(7):3326-36. PMID: 7522258.
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  321. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994 Aug 26; 265(5176):1237-40. PMID: 7520605.
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  322. Sobel RA, Greer JM, Kuchroo VK. Minireview: autoimmune responses to myelin proteolipid protein. Neurochem Res. 1994 Aug; 19(8):915-21. PMID: 7528354.
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  323. Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL, et al. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. J Exp Med. 1994 May 01; 179(5):1659-64. PMID: 8163944; PMCID: PMC2191471.
  324. Franco A, Southwood S, Arrhenius T, Kuchroo VK, Grey HM, Sette A, Ishioka GY. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis. Eur J Immunol. 1994 Apr; 24(4):940-6. PMID: 7512036.
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  325. Zamvil SS, al-Sabbagh A, Nelson PA, Kaul D, Charles MS, Mitchell DJ, Steinman L, Weiner HL, Kuchroo VK. 'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis. Pathobiology. 1994; 62(3):113-9. PMID: 7524528.
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  326. Kuchroo VK, Martin CA, Greer JM, Ju ST, Sobel RA, Dorf ME. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J Immunol. 1993 Oct 15; 151(8):4371-82. PMID: 7691946.
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  327. Byrne MC, O'Hara RM, Kuchroo VK, Jayaraman S, Rao A, Dorf ME, Collins M. The role of the T cell receptor alpha chain in antigen-specific immune suppression. Ann N Y Acad Sci. 1993 Jun 23; 685:611-3. PMID: 8363270.
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  328. Ozdemirli M, el-Khatib M, Bastiani L, Akdeniz H, Kuchroo V, Ju ST. The cytotoxic process of CD4 Th1 clones. J Immunol. 1992 Sep 15; 149(6):1889-95. PMID: 1355502.
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  329. Sobel RA, Kuchroo VK. The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions. J Immunol. 1992 Aug 15; 149(4):1444-51. PMID: 1380045.
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  330. Greer JM, Kuchroo VK, Sobel RA, Lees MB. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. J Immunol. 1992 Aug 01; 149(3):783-8. PMID: 1378866.
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  331. Dorf ME, Kuchroo VK, Collins M. Suppressor T cells: some answers but more questions. Immunol Today. 1992 Jul; 13(7):241-3. PMID: 1388648.
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  332. Kuchroo VK, Sobel RA, Laning JC, Martin CA, Greenfield E, Dorf ME, Lees MB. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage. J Immunol. 1992 Jun 15; 148(12):3776-82. PMID: 1376341.
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  333. Kuchroo VK, Byrne MC, Atsumi Y, Greenfield E, Connolly JB, Whitters MJ, O'Hara RM, Collins M, Dorf ME. T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8700-4. PMID: 1833764; PMCID: PMC52577.
  334. Kuchroo VK, Sobel RA, Yamamura T, Greenfield E, Dorf ME, Lees MB. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991; 59(5):305-12. PMID: 1716908.
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  335. Gallina MJ, Kuchroo VK, Steele JK. Serologic, biologic, and western blot analysis of a T suppressor factor with specificity for the hapten 4-hydroxy-3-nitrophenyl acetyl derived from serum-free medium. J Immunol. 1990 Dec 01; 145(11):3570-7. PMID: 2246502.
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  336. Collins M, Kuchroo VK, Whitters MJ, O'Hara RM, Kelleher K, Kubo RT, Dorf ME. Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function. J Immunol. 1990 Nov 01; 145(9):2809-19. PMID: 2170525.
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  337. Wilson SD, Kuchroo VK, Israel DI, Dorf ME. Expression and characterization of TCA3: a murine inflammatory protein. J Immunol. 1990 Oct 15; 145(8):2745-50. PMID: 2212660.
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  338. Kuchroo VK, Billings PR, Levine C, Martin CA, Kubo RT, Dorf ME. Antigen-specific and antibody-mediated growth inhibition of suppressor T cell hybridomas. Roles of H-2 and the CD3-T cell receptor-alpha/beta complex. J Immunol. 1990 Aug 15; 145(4):1059-65. PMID: 2143205.
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  339. Kuchroo VK, Steele JK, O'Hara RM, Jayaraman S, Selvaraj P, Greenfield E, Kubo RT, Dorf ME. Relationships between antigen-specific helper and inducer suppressor T cell hybridomas. J Immunol. 1990 Jul 15; 145(2):438-48. PMID: 1973182.
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  340. Ishikura H, Jayaraman S, Kuchroo V, Diamond B, Saito S, Dorf ME. Functional analysis of cloned macrophage hybridomas. VII. Modulation of suppressor T cell-inducing activity. J Immunol. 1989 Jul 15; 143(2):414-9. PMID: 2525585.
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  341. Kuchroo VK, Minami M, Diamond B, Dorf ME. Requirements for suppressor cell activation. Role of accessory cells. J Immunol. 1989 Apr 01; 142(7):2192-9. PMID: 2522479.
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  342. Steele JK, Kuchroo VK, Kawasaki H, Jayaraman S, Iwata M, Ishizaka K, Dorf ME. A monoclonal antibody raised to lipomodulin recognizes T suppressor factors in two independent hapten-specific suppressor networks. J Immunol. 1989 Apr 01; 142(7):2213-20. PMID: 2466892.
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  343. Kuchroo VK, Steele JK, Billings PR, Selvaraj P, Dorf ME. Expression of CD3-associated antigen-binding receptors on suppressor T cells. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9209-13. PMID: 2973609; PMCID: PMC282708.
  344. Ishikura H, Kuchroo V, Abromson-Leeman S, Dorf ME. Comparisons between helper and suppressor T-cell induction. Immunol Rev. 1988 Dec; 106:93-114. PMID: 2978156.
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  345. Dorf ME, Kuchroo VK, Steele JK, O'Hara RM. Understanding suppressor cells: where have we gone wrong? Int Rev Immunol. 1988 Aug; 3(4):375-92. PMID: 2977613.
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  346. Kuchroo VK, Noma T, Minami M, Dorf ME. Down-regulation of suppressor cell induction. Immunology. 1988 Aug; 64(4):633-42. PMID: 2459051; PMCID: PMC1384984.
  347. Kuchroo VK, Minami M, Diamond B, Dorf ME. Functional analysis of cloned macrophage hybridomas. VI. Differential ability to induce immunity or suppression. J Immunol. 1988 Jul 01; 141(1):10-6. PMID: 2454255.
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  348. Jaureguiberry B, Liao L, Kuchroo V, Dorf ME, Diamond B. Monoclonal anti-idiotypic antibodies to an I-J interacting molecule inhibit suppression in an H-2 restricted way. J Immunol. 1988 May 15; 140(10):3286-9. PMID: 2966194.
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  349. Steele JK, Kawasaki H, Kuchroo VK, Minami M, Levy JG, Dorf ME. A monoclonal antibody raised to tumor-specific T cell-derived suppressor factors also recognizes T suppressor inducer factors of the 4-hydroxy-3-nitrophenyl acetyl hapten suppressor network. J Immunol. 1987 Oct 15; 139(8):2629-34. PMID: 2443567.
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  350. Kuchroo VK, Lee VK, Hellström I, Hellström KE, Halliday WJ. Tumor-specific idiotopes on suppressor factors and suppressor cells revealed by monoclonal anti-idiotope antibodies. Cell Immunol. 1987 Jan; 104(1):105-14. PMID: 2948672.
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  351. Nelson M, Nelson DS, Kuchroo VK, Spradbrow PB, Jennings PA. Depression of cell-mediated immunity by tumour cell products: induction of resistance by immunotherapeutically active extracts of bovine ocular squamous cell carcinoma. Cancer Immunol Immunother. 1987; 24(3):231-6. PMID: 3594486.
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  352. Kuchroo VK, Halliday WJ. Cellular requirements for the suppression of leucocyte adherence inhibition reactions by serum factors from tumour-bearing mice. Immunology. 1986 Apr; 57(4):545-52. PMID: 2420706; PMCID: PMC1453871.
  353. Lee VK, Harriott TG, Kuchroo VK, Halliday WJ, Hellström I, Hellström KE. Monoclonal antiidiotypic antibodies related to a murine oncofetal bladder tumor antigen induce specific cell-mediated tumor immunity. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6286-90. PMID: 3875859; PMCID: PMC391038.
  354. Nelson M, Nelson DS, Spradbrow PB, Kuchroo VK, Jennings PA, Cianciolo GJ, Snyderman R. Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms. Clin Exp Immunol. 1985 Jul; 61(1):109-17. PMID: 4042416; PMCID: PMC1577247.
  355. Kuchroo VK, Spradbrow PB. Tumour-associated antigens in bovine ocular squamous cell carcinoma: studies with sera from tumour-bearing animals. Vet Immunol Immunopathol. 1985 May; 9(1):23-36. PMID: 3895721.
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  356. Kuchroo VK, Halliday WJ, Jennings PA, Spradbrow PB. Serum blocking factors in bovine ocular squamous cell carcinoma demonstrated by inhibition of erythrocyte rosette augmentation. Cancer Res. 1983 Mar; 43(3):1325-9. PMID: 6600651.
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  357. Kuchroo VK, Jennings PA, Spradbrow PB. Bovine ocular squamous cell carcinoma: tumor-associated immunity detected by E-rosette augmentation test. J Natl Cancer Inst. 1983 Feb; 70(2):305-9. PMID: 6600505.
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  358. Kuchroo VK, Jennings PA. Rosetting of bovine T-lymphocytes with autologous and allogeneic red blood cells. Vet Immunol Immunopathol. 1982 Sep; 3(5):461-74. PMID: 6983177.
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  359. Kuchroo VK, Dutta BM, Gupta RK. Tumour associated antigens in bovine horn cancer. Aust Vet J. 1982 Jan; 58(1):16-9. PMID: 6805457.
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  360. Kuchroo V, Gupta RK, Kalra DS. Thymus derived rosette forming cell counts and lymphocyte response to phytohaemagglutinin in animals affected with squamous cell carcinoma of horn. Res Vet Sci. 1981 Sep; 31(2):144-6. PMID: 6976603.
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  361. Gupta RK, Sadana JR, Kuchroo VK, Kalra DS. Horn cancer in an intact bull. Vet Rec. 1980 Sep 27; 107(13):312. PMID: 7210431.
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  362. Kuchroo V, Gupta RK, Kalra DS. Antigenic similarity between squamous cell carcinoma of horn (horn cancer) and normal bovine foetal tissues. Trop Anim Health Prod. 1979 Nov; 11(4):203-7. PMID: 95358.
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