Harvard Catalyst Profiles

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Jayaraj Rajagopal, M.D.

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Other Positions
Title
Institution
Department
Title
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. UG3CA268117 (DOU, ZHIXUN) Sep 22, 2021 - Aug 31, 2023
    NIH
    Single-cell proteomic identification of novel markers of senescence
    Role: Co-Principal Investigator
  2. R01HL148351 (RAJAGOPAL, JAYARAJ) Jul 1, 2020 - May 31, 2024
    NIH
    Mechanisms governing the physiologic regulation of cell fate: Hypoxia-induced differentiation of neuroendocrine cells from stem cells
    Role: Principal Investigator
  3. R01HL142559 (RAJAGOPAL, JAYARAJ) Sep 1, 2018 - Aug 31, 2022
    NIH
    Live Imaging of Intact Airway
    Role: Principal Investigator
  4. R01HL118185 (RAJAGOPAL, JAYARAJ) Feb 1, 2014 - Aug 31, 2022
    NIH
    Intercellular communication and cell regulation in airway epithelial ensembles in regeneration and disease
    Role: Principal Investigator
  5. R01HL116756 (RAJAGOPAL, JAYARAJ) Jul 15, 2013 - Jun 30, 2018
    NIH
    Defining the role of Hippo signaling in airway injury repair and remodeling
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Crossen AJ, Ward RA, Reedy JL, Surve MV, Klein BS, Rajagopal J, Vyas JM. Human Airway Epithelium Responses to Invasive Fungal Infections: A Critical Partner in Innate Immunity. J Fungi (Basel). 2022 Dec 27; 9(1). PMID: 36675861; PMCID: PMC9862202.
    Citations:    
  2. Onorati A, Havas AP, Lin B, Rajagopal J, Sen P, Adams PD, Dou Z. Upregulation of PD-L1 in Senescence and Aging. Mol Cell Biol. 2022 10 20; 42(10):e0017122. PMID: 36154662; PMCID: PMC9583718.
    Citations: 3     Fields:    Translation:AnimalsCells
  3. Shah VS, Chivukula RR, Lin B, Waghray A, Rajagopal J. Cystic Fibrosis and the Cells of the Airway Epithelium: What Are Ionocytes and What Do They Do? Annu Rev Pathol. 2022 01 24; 17:23-46. PMID: 34437820.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 07; 595(7865):107-113. PMID: 33915569; PMCID: PMC8919505.
    Citations: 104     Fields:    Translation:HumansCells
  5. Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, Ai X. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021 04 20; 35(3):109011. PMID: 33882306; PMCID: PMC8140387.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  6. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Bloom-Ackerman Z, Barkas N, Ganna A, Gomez J, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Gordon Jiang Z, Juric D, Babadi M, Farhi SL, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv. 2021 Feb 25. PMID: 33655247.
    Citations: 4     
  7. Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 01 01; 371(6524):52-57. PMID: 33384370.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  8. Montoro DT, Haber AL, Rood JE, Regev A, Rajagopal J. A Synthesis Concerning Conservation and Divergence of Cell Types across Epithelia. Cold Spring Harb Perspect Biol. 2020 11 02; 12(11). PMID: 32122885; PMCID: PMC7605222.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Segal E, Zhang F, Lin X, King G, Shalem O, Shilo S, Allen WE, Alquaddoomi F, Altae-Tran H, Anders S, Balicer R, Bauman T, Bonilla X, Booman G, Chan AT, Cohen O, Coletti S, Davidson N, Dor Y, Drew DA, Elemento O, Evans G, Ewels P, Gale J, Gavrieli A, Geiger B, Grad YH, Greene CS, Hajirasouliha I, Jerala R, Kahles A, Kallioniemi O, Keshet A, Kocarev L, Landua G, Meir T, Muller A, Nguyen LH, Oresic M, Ovchinnikova S, Peterson H, Prodanova J, Rajagopal J, Rätsch G, Rossman H, Rung J, Sboner A, Sigaras A, Spector T, Steinherz R, Stevens I, Vilo J, Wilmes P. Publisher Correction: Building an international consortium for tracking coronavirus health status. Nat Med. 2020 08; 26(8):1309. PMID: 32591764.
    Citations:    Fields:    
  10. Segal E, Zhang F, Lin X, King G, Shalem O, Shilo S, Allen WE, Alquaddoomi F, Altae-Tran H, Anders S, Balicer R, Bauman T, Bonilla X, Booman G, Chan AT, Cohen O, Coletti S, Davidson N, Dor Y, Drew DA, Elemento O, Evans G, Ewels P, Gale J, Gavrieli A, Geiger B, Grad YH, Greene CS, Hajirasouliha I, Jerala R, Kahles A, Kallioniemi O, Keshet A, Kocarev L, Landua G, Meir T, Muller A, Nguyen LH, Oresic M, Ovchinnikova S, Peterson H, Prodanova J, Rajagopal J, Rätsch G, Rossman H, Rung J, Sboner A, Sigaras A, Spector T, Steinherz R, Stevens I, Vilo J, Wilmes P. Building an international consortium for tracking coronavirus health status. Nat Med. 2020 08; 26(8):1161-1165. PMID: 32488218.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
  11. Lin D, Lin B, Bhanot H, Riou R, Abt NB, Rajagopal J, Saladi SV. RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers. Oral Oncol. 2020 12; 111:104930. PMID: 32745900.
    Citations: 2     Fields:    Translation:HumansCells
  12. Schiller HB, Montoro DT, Simon LM, Rawlins EL, Meyer KB, Strunz M, Vieira Braga FA, Timens W, Koppelman GH, Budinger GRS, Burgess JK, Waghray A, van den Berge M, Theis FJ, Regev A, Kaminski N, Rajagopal J, Teichmann SA, Misharin AV, Nawijn MC. The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. Am J Respir Cell Mol Biol. 2019 07; 61(1):31-41. PMID: 30995076.
    Citations: 62     Fields:    Translation:HumansCells
  13. Causton B, Pardo-Saganta A, Gillis J, Discipio K, Kooistra T, Rajagopal J, Xavier RJ, Cho JL, Medoff BD. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol. 2018 12; 59(6):684-694. PMID: 29958012; PMCID: PMC6293075.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  14. Vyas JM, Rajagopal J, Sokol CL, Wein MN, Mansour MK, Corey KE, Fishman MC, Armstrong KA. The Great Opportunity: Cultivating Scientific Inquiry in Medical Residency. J Infect Dis. 2018 08 14; 218(suppl_1):S44-S48. PMID: 29878132; PMCID: PMC6093444.
    Citations: 1     Fields:    Translation:Humans
  15. Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018 08; 560(7718):319-324. PMID: 30069044; PMCID: PMC6295155.
    Citations: 343     Fields:    Translation:HumansAnimalsCells
  16. Lin B, Srikanth P, Castle AC, Nigwekar S, Malhotra R, Galloway JL, Sykes DB, Rajagopal J. Modulating Cell Fate as a Therapeutic Strategy. Cell Stem Cell. 2018 09 06; 23(3):329-341. PMID: 29910150; PMCID: PMC6128730.
    Citations: 14     Fields:    Translation:HumansAnimals
  17. Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 2018 05 03; 22(5):779. PMID: 29727685; PMCID: PMC5940330.
    Citations: 15     Fields:    
  18. Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 2018 05 03; 22(5):653-667.e5. PMID: 29656941.
    Citations: 40     Fields:    Translation:AnimalsCells
  19. Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018 03 26; 44(6):679-693.e5. PMID: 29587142; PMCID: PMC5875457.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  20. Taylor MS, Chivukula RR, Myers LC, Jeck WR, Waghray A, Tata PR, Selig MK, O'Donnell WJ, Farver CF, Thompson BT, Rajagopal J, Kradin RL. A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury. Am J Pathol. 2018 05; 188(5):1149-1160. PMID: 29476724; PMCID: PMC5906746.
    Citations: 11     Fields:    Translation:Humans
  21. Taylor MS, Chivukula RR, Myers LC, Jeck WR, Tata PR, O'Donnell WJ, Farver CF, Thompson BT, Rajagopal J, Kradin RL. Delayed Alveolar Epithelialization: A Distinct Pathology in Diffuse Acute Lung Injury. Am J Respir Crit Care Med. 2018 02 15; 197(4):522-524. PMID: 28696778; PMCID: PMC5821904.
    Citations: 3     Fields:    Translation:Humans
  22. Paksa A, Rajagopal J. The epigenetic basis of cellular plasticity. Curr Opin Cell Biol. 2017 12; 49:116-122. PMID: 29413970; PMCID: PMC5949887.
    Citations: 20     Fields:    Translation:Humans
  23. Yonker LM, Pazos MA, Lanter BB, Mou H, Chu KK, Eaton AD, Bonventre JV, Tearney GJ, Rajagopal J, Hurley BP. Neutrophil-Derived Cytosolic PLA2a Contributes to Bacterial-Induced Neutrophil Transepithelial Migration. J Immunol. 2017 10 15; 199(8):2873-2884. PMID: 28887431; PMCID: PMC5636676.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Yonker LM, Mou H, Chu KK, Pazos MA, Leung H, Cui D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP. Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. Sci Rep. 2017 08 15; 7(1):8182. PMID: 28811631.
    Citations: 24     Fields:    Translation:HumansCells
  25. Waghray A, Rajagopal J. Tips from the embryonic lung. Elife. 2017 08 14; 6. PMID: 28806170.
    Citations:    Fields:    Translation:HumansCells
  26. Tata PR, Rajagopal J. Plasticity in the lung: making and breaking cell identity. Development. 2017 03 01; 144(5):755-766. PMID: 28246210.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  27. Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW. ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell. 2017 01 09; 31(1):35-49. PMID: 28041841; PMCID: PMC5225026.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  28. Tata PR, Rajagopal J. Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny. Cell Stem Cell. 2016 12 01; 19(6):686-689. PMID: 27912089.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Tata PR, Rajagopal J. Cellular plasticity: 1712 to the present day. Curr Opin Cell Biol. 2016 12; 43:46-54. PMID: 27485353; PMCID: PMC5154913.
    Citations: 32     Fields:    Translation:HumansAnimals
  30. Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhardt JF, Hsu YC, Rajagopal J. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016 08 04; 19(2):217-231. PMID: 27320041.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  31. Rajagopal J, Stanger BZ. Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues? Dev Cell. 2016 Jan 25; 36(2):133-7. PMID: 26812013.
    Citations: 29     Fields:    Translation:HumansAnimals
  32. Mou H, Brazauskas K, Rajagopal J. Personalized medicine for cystic fibrosis: establishing human model systems. Pediatr Pulmonol. 2015 Oct; 50 Suppl 40:S14-23. PMID: 26335952.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  33. Pardo-Saganta A, Tata PR, Law BM, Saez B, Chow RD, Prabhu M, Gridley T, Rajagopal J. Parent stem cells can serve as niches for their daughter cells. Nature. 2015 Jul 30; 523(7562):597-601. PMID: 26147083.
    Citations: 64     Fields:    Translation:AnimalsCells
  34. Causton B, Ramadas RA, Cho JL, Jones K, Pardo-Saganta A, Rajagopal J, Xavier RJ, Medoff BD. CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. J Immunol. 2015 Jul 15; 195(2):683-94. PMID: 26041536; PMCID: PMC4489191.
    Citations: 8     Fields:    Translation:AnimalsCells
  35. Dowdall JR, Sadow PM, Hartnick C, Vinarsky V, Mou H, Zhao R, Song PC, Franco RA, Rajagopal J. Identification of distinct layers within the stratified squamous epithelium of the adult human true vocal fold. Laryngoscope. 2015 Sep; 125(9):E313-9. PMID: 25988619.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  36. Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, Evans CM, Guindani M, Roche PA, Rajagopal J, Chen J, Davis CW, Tuvim MJ, Dickey BF. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. Biosci Rep. 2015 Apr 28; 35(3). PMID: 26182382; PMCID: PMC4613665.
    Citations: 14     Fields:    Translation:AnimalsCells
  37. Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, Evans CM, Guindani M, Roche PA, Rajagopal J, Chen J, Davis CW, Tuvim MJ, Dickey BF. SNAP23 Is Selectively Expressed in Airway Secretory Cells and Mediates Baseline and Stimulated Mucin Secretion. Biosci Rep. 2015 Apr 28. PMID: 25916184.
    Citations:    
  38. Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. J Exp Med. 2015 May 04; 212(5):759-74. PMID: 25918341; PMCID: PMC4419348.
    Citations: 58     Fields:    Translation:AnimalsCells
  39. Pardo-Saganta A, Law BM, Tata PR, Villoria J, Saez B, Mou H, Zhao R, Rajagopal J. Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell. 2015 Feb 05; 16(2):184-97. PMID: 25658372.
    Citations: 81     Fields:    Translation:AnimalsCells
  40. Gilpin SE, Ren X, Okamoto T, Guyette JP, Mou H, Rajagopal J, Mathisen DJ, Vacanti JP, Ott HC. Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. Ann Thorac Surg. 2014 Nov; 98(5):1721-9; discussion 1729. PMID: 25149047; PMCID: PMC4252658.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  41. Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell. 2014 Jul 28; 30(2):151-65. PMID: 25043474; PMCID: PMC4130488.
    Citations: 94     Fields:    Translation:AnimalsCells
  42. Guha A, Vasconcelos M, Zhao R, Gower AC, Rajagopal J, Cardoso WV. Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells. PLoS One. 2014; 9(2):e88848. PMID: 24586412.
    Citations: 18     Fields:    Translation:AnimalsCells
  43. Tata PR, Pardo-Saganta A, Prabhu M, Vinarsky V, Law BM, Fontaine BA, Tager AM, Rajagopal J. Airway-specific inducible transgene expression using aerosolized doxycycline. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1048-56. PMID: 23848320.
    Citations: 7     Fields:    Translation:AnimalsCells
  44. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 2013 Nov 14; 503(7475):218-23. PMID: 24196716.
    Citations: 286     Fields:    Translation:AnimalsCells
  45. Weiss DJ, Bates JH, Gilbert T, Liles WC, Lutzko C, Rajagopal J, Prockop D. Stem cells and cell therapies in lung biology and diseases: conference report. Ann Am Thorac Soc. 2013 Oct; 10(5):S25-44. PMID: 23869447.
    Citations: 24     Fields:    Translation:HumansCells
  46. Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, Rajagopal J, Jacks T, Meyerson M. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes Dev. 2013 Jan 15; 27(2):197-210. PMID: 23322301.
    Citations: 37     Fields:    Translation:HumansCells
  47. Pardo-Saganta A, Law BM, Gonzalez-Celeiro M, Vinarsky V, Rajagopal J. Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge. Am J Respir Cell Mol Biol. 2013 Mar; 48(3):364-73. PMID: 23239495.
    Citations: 34     Fields:    Translation:AnimalsCells
  48. Kim JK, Vinarsky V, Wain J, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH. In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol. 2012 Dec; 47(6):864-8. PMID: 22984086.
    Citations: 18     Fields:    Translation:AnimalsCells
  49. Muzykewicz DA, Black ME, Muse V, Numis AL, Rajagopal J, Thiele EA, Sharma A. Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex. J Comput Assist Tomogr. 2012 Sep-Oct; 36(5):518-22. PMID: 22992599.
    Citations: 14     Fields:    Translation:HumansCells
  50. Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 06; 10(4):398-411. PMID: 22482505.
    Citations: 173     Fields:    Translation:AnimalsCells
  51. Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell. 2012 Apr 06; 10(4):385-97. PMID: 22482504.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  52. Muzykewicz DA, Sharma A, Muse V, Numis AL, Rajagopal J, Thiele EA. TSC1 and TSC2 mutations in patients with lymphangioleiomyomatosis and tuberous sclerosis complex. J Med Genet. 2009 Jul; 46(7):465-8. PMID: 19419980.
    Citations: 26     Fields:    Translation:Humans
  53. Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development. 2009 May; 136(10):1751-9. PMID: 19369400.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  54. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development. 2009 Jan; 136(1):161-71. PMID: 19060336.
    Citations: 119     Fields:    Translation:AnimalsCells
  55. Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008 Nov 21; 322(5905):1247-50. PMID: 19023080.
    Citations: 295     Fields:    Translation:AnimalsCells
  56. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008 Oct 02; 455(7213):627-32. PMID: 18754011; PMCID: PMC9011918.
    Citations: 901     Fields:    Translation:AnimalsCells
  57. Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 2008 May; 135(9):1625-34. PMID: 18367557.
    Citations: 91     Fields:    Translation:AnimalsCells
  58. Anderson WJ, Zhou Q, Alcalde V, Kaneko OF, Blank LJ, Sherwood RI, Guseh JS, Rajagopal J, Melton DA. Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn. 2008 Feb; 237(2):504-12. PMID: 18213590; PMCID: PMC2665265.
    Citations: 29     Fields:    Translation:Animals
  59. Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA. A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul; 13(1):103-14. PMID: 17609113.
    Citations: 269     Fields:    Translation:AnimalsCells
  60. Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev. 2007 Mar 15; 21(6):694-707. PMID: 17369402; PMCID: PMC1820943.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  61. Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F. Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007 Jan; 12(1):113-27. PMID: 17199045; PMCID: PMC1861818.
    Citations: 132     Fields:    Translation:AnimalsCells
  62. Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, Englund MC, Heller RS, Håkansson J, Fleckner J, Sköld HN, Melton D, Semb H, Serup P. Artifactual insulin release from differentiated embryonic stem cells. Diabetes. 2004 Oct; 53(10):2603-9. PMID: 15448090.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  63. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science. 2003 Jan 17; 299(5605):363. PMID: 12532008.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  64. Rajagopal J, Kinane TB. Is there more to lung development than steroids and surfactant? Pediatrics. 2000 Nov; 106(5):1103-4. PMID: 11061782.
    Citations:    Fields:    Translation:HumansAnimals
  65. Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW. Mutational analysis of conserved nucleotides in a self-splicing group I intron. J Mol Biol. 1990 Oct 05; 215(3):345-58. PMID: 1700131.
    Citations: 19     Fields:    Translation:AnimalsCells
  66. Rajagopal J, Doudna JA, Szostak JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Science. 1989 May 12; 244(4905):692-4. PMID: 2470151.
    Citations: 24     Fields:    Translation:AnimalsCells
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