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Wade G. Regehr, Ph.D.


Calcium-Dependent Protein Kinase C Mediates Post-Tetanic Potentiation at the Calyx of Held
Summer, 06/01/10 - 09/30/10

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH122570 (REGEHR, WADE G) Mar 1, 2020 - Dec 31, 2024
    A novel output pathway from the cerebellum for regulation of diverse non-motor behaviors
    Role: Principal Investigator
  2. UF1NS108177 (SABATINI, BERNARDO L) Sep 30, 2018 - Sep 29, 2021
    Controlling the spatial extent of light-based monitoring and manipulation of neural activity in vivo
    Role: Co-Principal Investigator
  3. R35NS097284 (REGEHR, WADE G) Dec 1, 2016 - Nov 30, 2024
    Mechanisms and Functions of Synapses and Circuits
    Role: Principal Investigator
  4. R01NS092707 (REGEHR, WADE G) Sep 22, 2015 - Jun 30, 2020
    Regulation of Synchrony and Input Layer Excitability by Purkinje Cell Collaterals
    Role: Principal Investigator
  5. R21NS093498 (REGEHR, WADE G) May 1, 2015 - Apr 30, 2017
    Using silk as a biocompatible viral delivery system in the brain
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nguyen TM, Thomas LA, Rhoades JL, Ricchi I, Yuan XC, Yuan XC, Sheridan A, Hildebrand DGC, Funke J, Regehr WG, Lee WA. Publisher Correction: Structured cerebellar connectivity supports resilient pattern separation. Nature. 2023 Feb; 614(7946):E18. PMID: 36631615.
    Citations:    Fields:    
  2. Nguyen TM, Thomas LA, Rhoades JL, Ricchi I, Yuan XC, Yuan XC, Sheridan A, Hildebrand DGC, Funke J, Regehr WG, Lee WA. Structured cerebellar connectivity supports resilient pattern separation. Nature. 2023 01; 613(7944):543-549. PMID: 36418404.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Khan MM, Wu S, Chen CH, Regehr WG. Unusually Slow Spike Frequency Adaptation in Deep Cerebellar Nuclei Neurons Preserves Linear Transformations on the Subsecond Timescale. J Neurosci. 2022 10 05; 42(40):7581-7593. PMID: 35995561; PMCID: PMC9546444.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Hull C, Regehr WG. The Cerebellar Cortex. Annu Rev Neurosci. 2022 07 08; 45:151-175. PMID: 35803588.
    Citations: 4     Fields:    Translation:Cells
  5. Osorno T, Rudolph S, Nguyen T, Kozareva V, Nadaf NM, Norton A, Macosko EZ, Lee WA, Regehr WG. Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties. Nat Neurosci. 2022 06; 25(6):702-713. PMID: 35578131; PMCID: PMC9548381.
    Citations: 4     Fields:    Translation:AnimalsCells
  6. Kozareva V, Martin C, Osorno T, Rudolph S, Guo C, Vanderburg C, Nadaf N, Regev A, Regehr WG, Macosko E. Author Correction: A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types. Nature. 2022 Feb; 602(7896):E21. PMID: 35022615; PMCID: PMC8828463.
    Citations:    Fields:    
  7. Guo C, Huson V, Macosko EZ, Regehr WG. Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells. Nat Commun. 2021 10 07; 12(1):5491. PMID: 34620856; PMCID: PMC8497507.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Kozareva V, Martin C, Osorno T, Rudolph S, Guo C, Vanderburg C, Nadaf N, Regev A, Regehr WG, Macosko E. A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types. Nature. 2021 10; 598(7879):214-219. PMID: 34616064; PMCID: PMC8494635.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  9. Weyrer C, Turecek J, Harrison B, Regehr WG. Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse. Cell Rep. 2021 09 21; 36(12):109719. PMID: 34551307; PMCID: PMC9152841.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Guo C, Rudolph S, Neuwirth ME, Regehr WG. Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex. Elife. 2021 08 09; 10. PMID: 34369877.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Wang CC, Weyrer C, Fioravante D, Kaeser PS, Regehr WG. Presynaptic Short-Term Plasticity Persists in the Absence of PKC Phosphorylation of Munc18-1. J Neurosci. 2021 09 01; 41(35):7329-7339. PMID: 34290081; PMCID: PMC8412997.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Turecek J, Regehr WG. Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters. Elife. 2020 12 01; 9. PMID: 33259288.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Rudolph S, Guo C, Pashkovski SL, Osorno T, Gillis WF, Krauss JM, Nyitrai H, Flaquer I, El-Rifai M, Datta SR, Regehr WG. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep. 2020 11 03; 33(5):108338. PMID: 33147470; PMCID: PMC7700496.
    Citations: 11     Fields:    Translation:Animals
  14. Han KS, Chen CH, Khan MM, Guo C, Regehr WG. Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling. Nat Neurosci. 2020 11; 23(11):1399-1409. PMID: 32895566.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD. Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception. Science. 2020 06 19; 368(6497). PMID: 32554568.
    Citations: 29     Fields:    Translation:AnimalsCells
  16. Khan MM, Regehr WG. Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions. Elife. 2020 04 29; 9. PMID: 32347796.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Jackman SL, Chen CH, Offermann HL, Drew IR, Harrison BM, Bowman AM, Flick KM, Flaquer I, Regehr WG. Cerebellar Purkinje cell activity modulates aggressive behavior. Elife. 2020 04 28; 9. PMID: 32343225; PMCID: PMC7202893.
    Citations: 11     Fields:    Translation:AnimalsCells
  18. Huson V, Regehr WG. Diverse roles of Synaptotagmin-7 in regulating vesicle fusion. Curr Opin Neurobiol. 2020 08; 63:42-52. PMID: 32278209.
    Citations: 10     Fields:    Translation:Cells
  19. Jackman SL, Chen CH, Regehr WG. In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films. J Vis Exp. 2019 02 26; (144). PMID: 30882792.
    Citations: 2     Fields:    Translation:Animals
  20. Weyrer C, Turecek J, Niday Z, Liu PW, Nanou E, Catterall WA, Bean BP, Regehr WG. The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation. Cell Rep. 2019 02 26; 26(9):2289-2297.e3. PMID: 30811980.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Turecek J, Regehr WG. Neuronal Regulation of Fast Synaptotagmin Isoforms Controls the Relative Contributions of Synchronous and Asynchronous Release. Neuron. 2019 03 06; 101(5):938-949.e4. PMID: 30733150; PMCID: PMC6788794.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Tsai PT, Rudolph S, Guo C, Ellegood J, Gibson JM, Schaeffer SM, Mogavero J, Lerch JP, Regehr W, Sahin M. Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors. Cell Rep. 2018 10 09; 25(2):357-367.e4. PMID: 30304677; PMCID: PMC6226056.
    Citations: 36     Fields:    Translation:AnimalsCells
  23. Han KS, Guo C, Chen CH, Witter L, Osorno T, Regehr WG. Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells. Neuron. 2018 11 07; 100(3):564-578.e3. PMID: 30293822.
    Citations: 35     Fields:    Translation:AnimalsCells
  24. Turecek J, Regehr WG. Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses. J Neurosci. 2018 03 28; 38(13):3240-3251. PMID: 29593071; PMCID: PMC5884459.
    Citations: 39     Fields:    Translation:AnimalsCells
  25. Jackman SL, Chen CH, Chettih SN, Neufeld SQ, Drew IR, Agba CK, Flaquer I, Stefano AN, Kennedy TJ, Belinsky JE, Roberston K, Beron CC, Sabatini BL, Harvey CD, Regehr WG. Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins. Cell Rep. 2018 03 20; 22(12):3351-3361. PMID: 29562189.
    Citations: 8     Fields:    Translation:Humans
  26. Fioravante D, Chu Y, de Jong AP, Leitges M, Kaeser PS, Regehr WG. Retraction: Protein kinase C is a calcium sensor for presynaptic short-term plasticity. Elife. 2018 03 07; 7. PMID: 29512487.
    Citations: 1     Fields:    
  27. Turecek J, Jackman SL, Regehr WG. Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses. Nature. 2017 11 23; 551(7681):503-506. PMID: 29088700.
    Citations: 35     Fields:    Translation:AnimalsCells
  28. Jackman SL, Regehr WG. The Mechanisms and Functions of Synaptic Facilitation. Neuron. 2017 May 03; 94(3):447-464. PMID: 28472650.
    Citations: 135     Fields:    Translation:AnimalsCells
  29. Kaeser PS, Regehr WG. The readily releasable pool of synaptic vesicles. Curr Opin Neurobiol. 2017 04; 43:63-70. PMID: 28103533; PMCID: PMC5447466.
    Citations: 71     Fields:    Translation:HumansCells
  30. Turecek J, Jackman SL, Regehr WG. Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex. Cell Rep. 2016 12 20; 17(12):3256-3268. PMID: 28009294.
    Citations: 29     Fields:    Translation:AnimalsCells
  31. Guo C, Witter L, Rudolph S, Elliott HL, Ennis KA, Regehr WG. Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex. Neuron. 2016 Sep 21; 91(6):1330-1341. PMID: 27593180.
    Citations: 29     Fields:    Translation:AnimalsCells
  32. Witter L, Rudolph S, Pressler RT, Lahlaf SI, Regehr WG. Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons. Neuron. 2016 07 20; 91(2):312-9. PMID: 27346533.
    Citations: 49     Fields:    Translation:AnimalsCells
  33. Wang CC, Weyrer C, Paturu M, Fioravante D, Regehr WG. Calcium-Dependent Protein Kinase C Is Not Required for Post-Tetanic Potentiation at the Hippocampal CA3 to CA1 Synapse. J Neurosci. 2016 06 15; 36(24):6393-402. PMID: 27307229; PMCID: PMC5015777.
    Citations: 10     Fields:    Translation:AnimalsCells
  34. Thanawala MS, Regehr WG. Determining synaptic parameters using high-frequency activation. J Neurosci Methods. 2016 May 01; 264:136-152. PMID: 26972952; PMCID: PMC4833598.
    Citations: 24     Fields:    Translation:AnimalsCells
  35. Jackman SL, Turecek J, Belinsky JE, Regehr WG. The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature. 2016 Jan 07; 529(7584):88-91. PMID: 26738595.
    Citations: 139     Fields:    Translation:AnimalsCells
  36. Rudolph S, Hull C, Regehr WG. Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells. J Neurosci. 2015 Nov 25; 35(47):15492-504. PMID: 26609148; PMCID: PMC4659820.
    Citations: 9     Fields:    Translation:AnimalsCells
  37. Tang JC, Rudolph S, Dhande OS, Abraira VE, Choi S, Lapan SW, Drew IR, Drokhlyansky E, Huberman AD, Regehr WG, Cepko CL. Cell type-specific manipulation with GFP-dependent Cre recombinase. Nat Neurosci. 2015 Sep; 18(9):1334-41. PMID: 26258682; PMCID: PMC4839275.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  38. Fioravante D, Chu Y, de Jong AP, Leitges M, Kaeser PS, Regehr WG. Protein kinase C is a calcium sensor for presynaptic short-term plasticity. Elife. 2014 Aug 05; 3:e03011. PMID: 25097249.
    Citations: 13     Fields:    Translation:AnimalsCells
  39. Yamada T, Yang Y, Hemberg M, Yoshida T, Cho HY, Murphy JP, Fioravante D, Regehr WG, Gygi SP, Georgopoulos K, Bonni A. Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron. 2014 Jul 02; 83(1):122-34. PMID: 24991957.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  40. Brenowitz SD, Regehr WG. Presynaptic calcium measurements using bulk loading of acetoxymethyl indicators. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):750-7. PMID: 24987144.
    Citations: 2     Fields:    Translation:AnimalsCells
  41. Antal M, Beneduce BM, Regehr WG. The substantia nigra conveys target-dependent excitatory and inhibitory outputs from the basal ganglia to the thalamus. J Neurosci. 2014 Jun 04; 34(23):8032-42. PMID: 24899724.
    Citations: 18     Fields:    Translation:AnimalsCells
  42. Jackman SL, Beneduce BM, Drew IR, Regehr WG. Achieving high-frequency optical control of synaptic transmission. J Neurosci. 2014 May 28; 34(22):7704-14. PMID: 24872574.
    Citations: 81     Fields:    Translation:AnimalsCells
  43. Chu Y, Fioravante D, Leitges M, Regehr WG. Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity. Neuron. 2014 May 21; 82(4):859-71. PMID: 24794094.
    Citations: 19     Fields:    Translation:AnimalsCells
  44. Kaeser PS, Regehr WG. Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. Annu Rev Physiol. 2014; 76:333-63. PMID: 24274737.
    Citations: 194     Fields:    Translation:HumansAnimalsCells
  45. Liu A, Regehr WG. Normalization of input patterns in an associative network. J Neurophysiol. 2014 Feb; 111(3):544-51. PMID: 24225543.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  46. Hull CA, Chu Y, Thanawala M, Regehr WG. Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. J Neurosci. 2013 Apr 03; 33(14):5895-902. PMID: 23554471.
    Citations: 20     Fields:    Translation:AnimalsCells
  47. Thanawala MS, Regehr WG. Presynaptic calcium influx controls neurotransmitter release in part by regulating the effective size of the readily releasable pool. J Neurosci. 2013 Mar 13; 33(11):4625-33. PMID: 23486937.
    Citations: 78     Fields:    Translation:AnimalsCells
  48. Pressler RT, Regehr WG. Metabotropic glutamate receptors drive global persistent inhibition in the visual thalamus. J Neurosci. 2013 Feb 06; 33(6):2494-506. PMID: 23392677.
    Citations: 14     Fields:    Translation:AnimalsCells
  49. Chu Y, Fioravante D, Thanawala M, Leitges M, Regehr WG. Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. J Neurosci. 2012 Oct 03; 32(40):13796-804. PMID: 23035091.
    Citations: 10     Fields:    Translation:AnimalsCells
  50. Fioravante D, Myoga MH, Leitges M, Regehr WG. Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKC. J Neurosci. 2012 Sep 19; 32(38):13004-9. PMID: 22993418.
    Citations: 7     Fields:    Translation:AnimalsCells
  51. Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 2012 Aug 30; 488(7413):647-51. PMID: 22763451; PMCID: PMC3615424.
    Citations: 391     Fields:    Translation:AnimalsCells
  52. Regehr WG. Short-term presynaptic plasticity. Cold Spring Harb Perspect Biol. 2012 Jul 01; 4(7):a005702. PMID: 22751149.
    Citations: 198     Fields:    Translation:HumansAnimalsCells
  53. Brenowitz SD, Regehr WG. Presynaptic imaging of projection fibers by in vivo injection of dextran-conjugated calcium indicators. Cold Spring Harb Protoc. 2012 Apr 01; 2012(4):465-71. PMID: 22474660.
    Citations: 3     Fields:    Translation:AnimalsCells
  54. Hull C, Regehr WG. Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron. 2012 Jan 12; 73(1):149-58. PMID: 22243753.
    Citations: 63     Fields:    Translation:AnimalsCells
  55. Fioravante D, Chu Y, Myoga MH, Leitges M, Regehr WG. Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron. 2011 Jun 09; 70(5):1005-19. PMID: 21658591.
    Citations: 35     Fields:    Translation:AnimalsCells
  56. Myoga MH, Regehr WG. Calcium microdomains near R-type calcium channels control the induction of presynaptic long-term potentiation at parallel fiber to purkinje cell synapses. J Neurosci. 2011 Apr 06; 31(14):5235-43. PMID: 21471358.
    Citations: 21     Fields:    Translation:AnimalsCells
  57. Fioravante D, Regehr WG. Short-term forms of presynaptic plasticity. Curr Opin Neurobiol. 2011 Apr; 21(2):269-74. PMID: 21353526.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  58. Carey MR, Myoga MH, McDaniels KR, Marsicano G, Lutz B, Mackie K, Regehr WG. Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses. J Neurophysiol. 2011 Feb; 105(2):958-63. PMID: 21084685.
    Citations: 25     Fields:    Translation:AnimalsCells
  59. Carey MR, Regehr WG. Phosphatase activity controls the ups and downs of cerebellar learning. Neuron. 2010 Aug 26; 67(4):525-6. PMID: 20797529.
    Citations: 1     Fields:    
  60. Antal M, Acuna-Goycolea C, Pressler RT, Blitz DM, Regehr WG. Cholinergic activation of M2 receptors leads to context-dependent modulation of feedforward inhibition in the visual thalamus. PLoS Biol. 2010 Apr 06; 8(4):e1000348. PMID: 20386723.
    Citations: 15     Fields:    Translation:AnimalsCells
  61. Best AR, Regehr WG. Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain. Neuron. 2010 Feb 11; 65(3):291-2. PMID: 20159441.
    Citations: 5     Fields:    Translation:AnimalsCells
  62. Crowley JJ, Fioravante D, Regehr WG. Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration. Neuron. 2009 Sep 24; 63(6):843-53. PMID: 19778512.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  63. Kim JC, Cook MN, Carey MR, Shen C, Regehr WG, Dymecki SM. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron. 2009 Aug 13; 63(3):305-15. PMID: 19679071.
    Citations: 73     Fields:    Translation:AnimalsCells
  64. Regehr WG, Carey MR, Best AR. Activity-dependent regulation of synapses by retrograde messengers. Neuron. 2009 Jul 30; 63(2):154-70. PMID: 19640475.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  65. Myoga MH, Beierlein M, Regehr WG. Somatic spikes regulate dendritic signaling in small neurons in the absence of backpropagating action potentials. J Neurosci. 2009 Jun 17; 29(24):7803-14. PMID: 19535592.
    Citations: 15     Fields:    Translation:AnimalsCells
  66. Best AR, Regehr WG. Inhibitory regulation of electrically coupled neurons in the inferior olive is mediated by asynchronous release of GABA. Neuron. 2009 May 28; 62(4):555-65. PMID: 19477156.
    Citations: 67     Fields:    Translation:AnimalsCells
  67. Carey MR, Regehr WG. Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals. Neuron. 2009 Apr 16; 62(1):112-22. PMID: 19376071.
    Citations: 37     Fields:    Translation:AnimalsCells
  68. Xu-Friedman MA, Regehr WG. Retrograde tuning of tuning. Neuron. 2008 Jul 10; 59(1):3-5. PMID: 18614023.
    Citations:    Fields:    Translation:AnimalsCells
  69. Best AR, Regehr WG. Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapses. J Neurosci. 2008 Jun 18; 28(25):6508-15. PMID: 18562622.
    Citations: 48     Fields:    Translation:AnimalsCells
  70. Acuna-Goycolea C, Brenowitz SD, Regehr WG. Active dendritic conductances dynamically regulate GABA release from thalamic interneurons. Neuron. 2008 Feb 07; 57(3):420-31. PMID: 18255034.
    Citations: 41     Fields:    Translation:AnimalsCells
  71. Brenowitz SD, Regehr WG. Reliability and heterogeneity of calcium signaling at single presynaptic boutons of cerebellar granule cells. J Neurosci. 2007 Jul 25; 27(30):7888-98. PMID: 17652580; PMCID: PMC6672738.
    Citations: 62     Fields:    Translation:AnimalsCells
  72. Safo P, Regehr WG. Timing dependence of the induction of cerebellar LTD. Neuropharmacology. 2008 Jan; 54(1):213-8. PMID: 17669443.
    Citations: 40     Fields:    Translation:AnimalsCells
  73. Beierlein M, Fioravante D, Regehr WG. Differential expression of posttetanic potentiation and retrograde signaling mediate target-dependent short-term synaptic plasticity. Neuron. 2007 Jun 21; 54(6):949-59. PMID: 17582334.
    Citations: 44     Fields:    Translation:AnimalsCells
  74. Crowley JJ, Carter AG, Regehr WG. Fast vesicle replenishment and rapid recovery from desensitization at a single synaptic release site. J Neurosci. 2007 May 16; 27(20):5448-60. PMID: 17507567; PMCID: PMC6672343.
    Citations: 38     Fields:    Translation:AnimalsCells
  75. Beierlein M, Regehr WG. Local interneurons regulate synaptic strength by retrograde release of endocannabinoids. J Neurosci. 2006 Sep 27; 26(39):9935-43. PMID: 17005857; PMCID: PMC6674464.
    Citations: 39     Fields:    Translation:AnimalsCells
  76. Beierlein M, Regehr WG. Brief bursts of parallel fiber activity trigger calcium signals in bergmann glia. J Neurosci. 2006 Jun 28; 26(26):6958-67. PMID: 16807325; PMCID: PMC6673913.
    Citations: 33     Fields:    Translation:AnimalsCells
  77. Brenowitz SD, Best AR, Regehr WG. Sustained elevation of dendritic calcium evokes widespread endocannabinoid release and suppression of synapses onto cerebellar Purkinje cells. J Neurosci. 2006 Jun 21; 26(25):6841-50. PMID: 16793891; PMCID: PMC6673843.
    Citations: 27     Fields:    Translation:AnimalsCells
  78. Safo PK, Cravatt BF, Regehr WG. Retrograde endocannabinoid signaling in the cerebellar cortex. Cerebellum. 2006; 5(2):134-45. PMID: 16818388.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  79. Foster KA, Crowley JJ, Regehr WG. The influence of multivesicular release and postsynaptic receptor saturation on transmission at granule cell to Purkinje cell synapses. J Neurosci. 2005 Dec 14; 25(50):11655-65. PMID: 16354924; PMCID: PMC6726039.
    Citations: 44     Fields:    Translation:AnimalsCells
  80. Safo PK, Regehr WG. Endocannabinoids control the induction of cerebellar LTD. Neuron. 2005 Nov 23; 48(4):647-59. PMID: 16301180.
    Citations: 124     Fields:    Translation:AnimalsCells
  81. Xu-Friedman MA, Regehr WG. Dynamic-clamp analysis of the effects of convergence on spike timing. I. Many synaptic inputs. J Neurophysiol. 2005 Oct; 94(4):2512-25. PMID: 16160092.
    Citations: 27     Fields:    Translation:AnimalsCells
  82. Xu-Friedman MA, Regehr WG. Dynamic-clamp analysis of the effects of convergence on spike timing. II. Few synaptic inputs. J Neurophysiol. 2005 Oct; 94(4):2526-34. PMID: 16160093.
    Citations: 24     Fields:    Translation:AnimalsCells
  83. Beierlein M, Regehr WG. Conventional synapses for unconventional cells. Neuron. 2005 Jun 02; 46(5):694-6. PMID: 15924854.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  84. Blitz DM, Regehr WG. Timing and specificity of feed-forward inhibition within the LGN. Neuron. 2005 Mar 24; 45(6):917-28. PMID: 15797552.
    Citations: 77     Fields:    Translation:AnimalsCells
  85. Brenowitz SD, Regehr WG. Associative short-term synaptic plasticity mediated by endocannabinoids. Neuron. 2005 Feb 03; 45(3):419-31. PMID: 15694328.
    Citations: 88     Fields:    Translation:AnimalsCells
  86. Abbott LF, Regehr WG. Synaptic computation. Nature. 2004 Oct 14; 431(7010):796-803. PMID: 15483601.
    Citations: 449     Fields:    Translation:AnimalsCells
  87. Blitz DM, Foster KA, Regehr WG. Short-term synaptic plasticity: a comparison of two synapses. Nat Rev Neurosci. 2004 Aug; 5(8):630-40. PMID: 15263893.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  88. Foster KA, Regehr WG. Variance-mean analysis in the presence of a rapid antagonist indicates vesicle depletion underlies depression at the climbing fiber synapse. Neuron. 2004 Jul 08; 43(1):119-31. PMID: 15233922.
    Citations: 58     Fields:    Translation:AnimalsCells
  89. Beierlein M, Gee KR, Martin VV, Regehr WG. Presynaptic calcium measurements at physiological temperatures using a new class of dextran-conjugated indicators. J Neurophysiol. 2004 Jul; 92(1):591-9. PMID: 15212445.
    Citations: 19     Fields:    Translation:AnimalsCells
  90. Brown SP, Safo PK, Regehr WG. Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels. J Neurosci. 2004 Jun 16; 24(24):5623-31. PMID: 15201335; PMCID: PMC6729326.
    Citations: 69     Fields:    Translation:AnimalsCells
  91. Xu-Friedman MA, Regehr WG. Structural contributions to short-term synaptic plasticity. Physiol Rev. 2004 Jan; 84(1):69-85. PMID: 14715911.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  92. Blitz DM, Regehr WG. Retinogeniculate synaptic properties controlling spike number and timing in relay neurons. J Neurophysiol. 2003 Oct; 90(4):2438-50. PMID: 14534270.
    Citations: 30     Fields:    Translation:AnimalsCells
  93. Brown SP, Brenowitz SD, Regehr WG. Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids. Nat Neurosci. 2003 Oct; 6(10):1048-57. PMID: 14502290.
    Citations: 113     Fields:    Translation:AnimalsCells
  94. Brenowitz SD, Regehr WG. "Resistant" channels reluctantly reveal their roles. Neuron. 2003 Jul 31; 39(3):391-4. PMID: 12895414.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  95. Brenowitz SD, Regehr WG. Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto Purkinje cells. J Neurosci. 2003 Jul 16; 23(15):6373-84. PMID: 12867523; PMCID: PMC6740543.
    Citations: 47     Fields:    Translation:AnimalsCells
  96. Chen C, Regehr WG. Presynaptic modulation of the retinogeniculate synapse. J Neurosci. 2003 Apr 15; 23(8):3130-5. PMID: 12716920; PMCID: PMC6742324.
    Citations: 53     Fields:    Translation:AnimalsCells
  97. Xu-Friedman MA, Regehr WG. Ultrastructural contributions to desensitization at cerebellar mossy fiber to granule cell synapses. J Neurosci. 2003 Mar 15; 23(6):2182-92. PMID: 12657677; PMCID: PMC6742013.
    Citations: 64     Fields:    Translation:AnimalsCells
  98. Foster KA, Kreitzer AC, Regehr WG. Interaction of postsynaptic receptor saturation with presynaptic mechanisms produces a reliable synapse. Neuron. 2002 Dec 19; 36(6):1115-26. PMID: 12495626.
    Citations: 55     Fields:    Translation:AnimalsCells
  99. Carter AG, Regehr WG. Quantal events shape cerebellar interneuron firing. Nat Neurosci. 2002 Dec; 5(12):1309-18. PMID: 12411959.
    Citations: 105     Fields:    Translation:AnimalsCells
  100. Kreitzer AC, Regehr WG. Retrograde signaling by endocannabinoids. Curr Opin Neurobiol. 2002 Jun; 12(3):324-30. PMID: 12049940.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  101. Kreitzer AC, Carter AG, Regehr WG. Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum. Neuron. 2002 May 30; 34(5):787-96. PMID: 12062024.
    Citations: 67     Fields:    Translation:AnimalsCells
  102. Chen C, Blitz DM, Regehr WG. Contributions of receptor desensitization and saturation to plasticity at the retinogeniculate synapse. Neuron. 2002 Feb 28; 33(5):779-88. PMID: 11879654.
    Citations: 78     Fields:    Translation:AnimalsCells
  103. Zucker RS, Regehr WG. Short-term synaptic plasticity. Annu Rev Physiol. 2002; 64:355-405. PMID: 11826273.
    Citations: 1712     Fields:    Translation:AnimalsCells
  104. Carter AG, Vogt KE, Foster KA, Regehr WG. Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses. J Neurosci. 2002 Jan 01; 22(1):21-8. PMID: 11756484; PMCID: PMC6757598.
    Citations: 70     Fields:    Translation:AnimalsCells
  105. Kreitzer AC, Regehr WG. Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J Neurosci. 2001 Oct 15; 21(20):RC174. PMID: 11588204; PMCID: PMC6763870.
    Citations: 130     Fields:    Translation:AnimalsCells
  106. Xu-Friedman MA, Harris KM, Regehr WG. Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells. J Neurosci. 2001 Sep 01; 21(17):6666-72. PMID: 11517256; PMCID: PMC6763067.
    Citations: 132     Fields:    Translation:AnimalsCells
  107. Kreitzer AC, Regehr WG. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron. 2001 Mar; 29(3):717-27. PMID: 11301030.
    Citations: 352     Fields:    Translation:AnimalsCells
  108. Vogt KE, Regehr WG. Cholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus. J Neurosci. 2001 Jan 01; 21(1):75-83. PMID: 11150322; PMCID: PMC6762445.
    Citations: 56     Fields:    Translation:AnimalsCells
  109. Xu-Friedman MA, Regehr WG. Maximinis. Nat Neurosci. 2000 Dec; 3(12):1229-30. PMID: 11100136.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  110. Chen C, Regehr WG. Developmental remodeling of the retinogeniculate synapse. Neuron. 2000 Dec; 28(3):955-66. PMID: 11163279.
    Citations: 205     Fields:    Translation:AnimalsCells
  111. Kreitzer AC, Gee KR, Archer EA, Regehr WG. Monitoring presynaptic calcium dynamics in projection fibers by in vivo loading of a novel calcium indicator. Neuron. 2000 Jul; 27(1):25-32. PMID: 10939328.
    Citations: 33     Fields:    Translation:AnimalsCells
  112. Carter AG, Regehr WG. Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse. J Neurosci. 2000 Jun 15; 20(12):4423-34. PMID: 10844011; PMCID: PMC6772456.
    Citations: 109     Fields:    Translation:AnimalsCells
  113. Xu-Friedman MA, Regehr WG. Probing fundamental aspects of synaptic transmission with strontium. J Neurosci. 2000 Jun 15; 20(12):4414-22. PMID: 10844010; PMCID: PMC6772435.
    Citations: 83     Fields:    Translation:AnimalsCells
  114. Kreitzer AC, Regehr WG. Modulation of transmission during trains at a cerebellar synapse. J Neurosci. 2000 Feb 15; 20(4):1348-57. PMID: 10662825; PMCID: PMC6772360.
    Citations: 42     Fields:    Translation:AnimalsCells
  115. Dittman JS, Kreitzer AC, Regehr WG. Interplay between facilitation, depression, and residual calcium at three presynaptic terminals. J Neurosci. 2000 Feb 15; 20(4):1374-85. PMID: 10662828; PMCID: PMC6772383.
    Citations: 224     Fields:    Translation:AnimalsCells
  116. Chen C, Regehr WG. Contributions of residual calcium to fast synaptic transmission. J Neurosci. 1999 Aug 01; 19(15):6257-66. PMID: 10414955; PMCID: PMC6782810.
    Citations: 41     Fields:    Translation:AnimalsCells
  117. Xu-Friedman MA, Regehr WG. Presynaptic strontium dynamics and synaptic transmission. Biophys J. 1999 Apr; 76(4):2029-42. PMID: 10096899; PMCID: PMC1300177.
    Citations: 53     Fields:    Translation:AnimalsCells
  118. Sabatini BL, Regehr WG. Timing of synaptic transmission. Annu Rev Physiol. 1999; 61:521-42. PMID: 10099700.
    Citations: 97     Fields:    Translation:AnimalsCells
  119. Atluri PP, Regehr WG. Delayed release of neurotransmitter from cerebellar granule cells. J Neurosci. 1998 Oct 15; 18(20):8214-27. PMID: 9763467; PMCID: PMC6792848.
    Citations: 121     Fields:    Translation:AnimalsCells
  120. Dittman JS, Regehr WG. Calcium dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse. J Neurosci. 1998 Aug 15; 18(16):6147-62. PMID: 9698309; PMCID: PMC6793194.
    Citations: 203     Fields:    Translation:AnimalsCells
  121. Sabatini BL, Regehr WG. Optical measurement of presynaptic calcium currents. Biophys J. 1998 Mar; 74(3):1549-63. PMID: 9512051; PMCID: PMC1299501.
    Citations: 57     Fields:    Translation:AnimalsCells
  122. Dittman JS, Regehr WG. Mechanism and kinetics of heterosynaptic depression at a cerebellar synapse. J Neurosci. 1997 Dec 01; 17(23):9048-59. PMID: 9364051; PMCID: PMC6573588.
    Citations: 49     Fields:    Translation:AnimalsCells
  123. Chen C, Regehr WG. The mechanism of cAMP-mediated enhancement at a cerebellar synapse. J Neurosci. 1997 Nov 15; 17(22):8687-94. PMID: 9348337; PMCID: PMC6573078.
    Citations: 84     Fields:    Translation:AnimalsCells
  124. Regehr WG. Interplay between sodium and calcium dynamics in granule cell presynaptic terminals. Biophys J. 1997 Nov; 73(5):2476-88. PMID: 9370441; PMCID: PMC1181149.
    Citations: 29     Fields:    Translation:AnimalsCells
  125. Sabatini BL, Regehr WG. Control of neurotransmitter release by presynaptic waveform at the granule cell to Purkinje cell synapse. J Neurosci. 1997 May 15; 17(10):3425-35. PMID: 9133368; PMCID: PMC6573699.
    Citations: 139     Fields:    Translation:AnimalsCells
  126. Connors BW, Regehr WG. Neuronal firing: does function follow form? Curr Biol. 1996 Dec 01; 6(12):1560-2. PMID: 8994812.
    Citations: 13     Fields:    Translation:AnimalsCells
  127. Sabatini BL, Regehr WG. Timing of neurotransmission at fast synapses in the mammalian brain. Nature. 1996 Nov 14; 384(6605):170-2. PMID: 8906792.
    Citations: 160     Fields:    Translation:AnimalsCells
  128. Atluri PP, Regehr WG. Determinants of the time course of facilitation at the granule cell to Purkinje cell synapse. J Neurosci. 1996 Sep 15; 16(18):5661-71. PMID: 8795622; PMCID: PMC6578977.
    Citations: 172     Fields:    Translation:AnimalsCells
  129. Dittman JS, Regehr WG. Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse. J Neurosci. 1996 Mar 01; 16(5):1623-33. PMID: 8774431; PMCID: PMC6578681.
    Citations: 127     Fields:    Translation:AnimalsCells
  130. Tank DW, Regehr WG, Delaney KR. A quantitative analysis of presynaptic calcium dynamics that contribute to short-term enhancement. J Neurosci. 1995 Dec; 15(12):7940-52. PMID: 8613732; PMCID: PMC6577935.
    Citations: 83     Fields:    Translation:AnimalsCells
  131. Sabatini BL, Regehr WG. Detecting changes in calcium influx which contribute to synaptic modulation in mammalian brain slice. Neuropharmacology. 1995 Nov; 34(11):1453-67. PMID: 8606793.
    Citations: 20     Fields:    Translation:AnimalsCells
  132. Mintz IM, Sabatini BL, Regehr WG. Calcium control of transmitter release at a cerebellar synapse. Neuron. 1995 Sep; 15(3):675-88. PMID: 7546746.
    Citations: 226     Fields:    Translation:AnimalsCells
  133. Regehr WG, Atluri PP. Calcium transients in cerebellar granule cell presynaptic terminals. Biophys J. 1995 May; 68(5):2156-70. PMID: 7612860; PMCID: PMC1282121.
    Citations: 76     Fields:    Translation:AnimalsCells
  134. Regehr WG, Tank DW. Dendritic calcium dynamics. Curr Opin Neurobiol. 1994 Jun; 4(3):373-82. PMID: 7919932.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  135. Regehr WG, Armstrong CM. Dendritic function. Where does it all begin? Curr Biol. 1994 May 01; 4(5):436-9. PMID: 7922359.
    Citations: 3     Fields:    Translation:AnimalsCells
  136. Regehr WG, Mintz IM. Participation of multiple calcium channel types in transmission at single climbing fiber to Purkinje cell synapses. Neuron. 1994 Mar; 12(3):605-13. PMID: 8155322.
    Citations: 69     Fields:    Translation:AnimalsCells
  137. Regehr WG, Delaney KR, Tank DW. The role of presynaptic calcium in short-term enhancement at the hippocampal mossy fiber synapse. J Neurosci. 1994 Feb; 14(2):523-37. PMID: 8301352; PMCID: PMC6576812.
    Citations: 117     Fields:    Translation:AnimalsCells
  138. Regehr W, Kehoe JS, Ascher P, Armstrong C. Synaptically triggered action potentials in dendrites. Neuron. 1993 Jul; 11(1):145-51. PMID: 8338663.
    Citations: 23     Fields:    Translation:AnimalsCells
  139. Regehr WG, Tank DW. Calcium concentration dynamics produced by synaptic activation of CA1 hippocampal pyramidal cells. J Neurosci. 1992 Nov; 12(11):4202-23. PMID: 1359030; PMCID: PMC6576011.
    Citations: 65     Fields:    Translation:AnimalsCells
  140. Regehr WG, Konnerth A, Armstrong CM. Sodium action potentials in the dendrites of cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 1992 Jun 15; 89(12):5492-6. PMID: 1608959; PMCID: PMC49318.
    Citations: 7     Fields:    Translation:AnimalsCells
  141. Garyantes TK, Regehr WG. Electrical activity increases growth cone calcium but fails to inhibit neurite outgrowth from rat sympathetic neurons. J Neurosci. 1992 Jan; 12(1):96-103. PMID: 1729445; PMCID: PMC6575705.
    Citations: 7     Fields:    Translation:AnimalsCells
  142. Regehr WG, Tank DW. The maintenance of LTP at hippocampal mossy fiber synapses is independent of sustained presynaptic calcium. Neuron. 1991 Sep; 7(3):451-9. PMID: 1654950.
    Citations: 19     Fields:    Translation:AnimalsCells
  143. Regehr WG, Tank DW. Selective fura-2 loading of presynaptic terminals and nerve cell processes by local perfusion in mammalian brain slice. J Neurosci Methods. 1991 Apr; 37(2):111-9. PMID: 1881195.
    Citations: 51     Fields:    Translation:Animals
  144. Regehr WG, Tank DW. Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CA1 pyramidal cell dendrites. Nature. 1990 Jun 28; 345(6278):807-10. PMID: 1972782.
    Citations: 38     Fields:    Translation:AnimalsCells
  145. Regehr WG, Pine J, Cohan CS, Mischke MD, Tank DW. Sealing cultured invertebrate neurons to embedded dish electrodes facilitates long-term stimulation and recording. J Neurosci Methods. 1989 Nov; 30(2):91-106. PMID: 2586157.
    Citations: 31     Fields:    Translation:AnimalsCells
  146. Regehr WG, Connor JA, Tank DW. Optical imaging of calcium accumulation in hippocampal pyramidal cells during synaptic activation. Nature. 1989 Oct 12; 341(6242):533-6. PMID: 2797180.
    Citations: 50     Fields:    Translation:AnimalsCells
  147. Regehr WG, Pine J, Rutledge DB. A long-term in vitro silicon-based microelectrode-neuron connection. IEEE Trans Biomed Eng. 1988 Dec; 35(12):1023-32. PMID: 3220496.
    Citations: 4     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.