Harvard Catalyst Profiles

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Marc Nathan Wein, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK116716 (WEIN, MARC NATHAN) Sep 15, 2018 - Jun 30, 2023
    The role of salt inducible kinases in parathyroid hormone action in bone
    Role: Principal Investigator
  2. R03AR072903 (WEIN, MARC NATHAN) Mar 1, 2018 - Feb 29, 2020
    Reducing cartilage destruction in osteoarthritis with the small molecule SIK inhibitor YKL-05-099
    Role: Principal Investigator
  3. R03AR072150 (WEIN, MARC NATHAN) Sep 1, 2017 - Aug 31, 2019
    Skeletal effects of the small molecule SIK inhibitor YKL-05-099
    Role: Principal Investigator
  4. K08AR067285 (WEIN, MARC NATHAN) Apr 1, 2015 - Mar 31, 2020
    Dissecting the roles of class IIa HDACs in osteocyte biology
    Role: Principal Investigator
  5. F32DK100215 (WEIN, MARC NATHAN) Aug 1, 2013 - Jul 31, 2015
    The role of class II histone deacetylases in PTH signaling in osteocytes
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sato T, Verma S, Khatri A, Dean T, Goransson O, Gardella TJ, Wein MN. Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH. JBMR Plus. 2021 May; 5(5):e10441. PMID: 33977197.
  2. Wang JS, Mazur CM, Wein MN. Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones. Front Endocrinol (Lausanne). 2021; 12:584147. PMID: 33776907.
  3. Nishimori S, Wein MN, Kronenberg HM. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. Bone. 2021 01; 142:115709. PMID: 33148508.
    Citations: 1     Fields:    
  4. Wang JS, Yoon SH, Wein MN. Role of histone deacetylases in bone development and skeletal disorders. Bone. 2021 02; 143:115606. PMID: 32829038.
    Citations: 3     Fields:    
  5. Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Nat Commun. 2020 07 01; 11(1):3282. PMID: 32612176.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  6. Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 03 02; 130(3):1513-1526. PMID: 32065590.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Nishimori S, O'Meara MJ, Castro CD, Noda H, Cetinbas M, da Silva Martins J, Ayturk U, Brooks DJ, Bruce M, Nagata M, Ono W, Janton CJ, Bouxsein ML, Foretz M, Berdeaux R, Sadreyev RI, Gardella TJ, Jüppner H, Kronenberg HM, Wein MN. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling. J Clin Invest. 2019 12 02; 129(12):5187-5203. PMID: 31430259.
    Citations: 8     Fields:    Translation:AnimalsCells
  8. He Q, Shumate LT, Matthias J, Aydin C, Wein MN, Spatz JM, Goetz R, Mohammadi M, Plagge A, Divieti Pajevic P, Bastepe M. A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23. JCI Insight. 2019 09 05; 4(17). PMID: 31484825.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Sun N, Uda Y, Azab E, Kochen A, Santos RNCE, Shi C, Kobayashi T, Wein MN, Divieti Pajevic P. Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. J Biol Chem. 2019 06 21; 294(25):9722-9733. PMID: 31068415.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM. Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723-735, 2018). Trends Endocrinol Metab. 2019 Jun; 30(6):407. PMID: 30837108.
    Citations: 3     Fields:    
  11. Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM. Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab. 2018 10; 29(10):723-735. PMID: 30150136.
    Citations: 26     Fields:    Translation:HumansCells
  12. Vyas JM, Rajagopal J, Sokol CL, Wein MN, Mansour MK, Corey KE, Fishman MC, Armstrong KA. The Great Opportunity: Cultivating Scientific Inquiry in Medical Residency. J Infect Dis. 2018 08 14; 218(suppl_1):S44-S48. PMID: 29878132.
    Citations: 1     Fields:    Translation:Humans
  13. Wein MN, Kronenberg HM. Regulation of Bone Remodeling by Parathyroid Hormone. Cold Spring Harb Perspect Med. 2018 08 01; 8(8). PMID: 29358318.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  14. Wein MN. Parathyroid Hormone Signaling in Osteocytes. JBMR Plus. 2018 Jan; 2(1):22-30. PMID: 30283888.
    Citations: 10     
  15. Tokarz D, Cisek R, Wein MN, Turcotte R, Haase C, Yeh SA, Bharadwaj S, Raphael AP, Paudel H, Alt C, Liu TM, Kronenberg HM, Lin CP. Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy. PLoS One. 2017; 12(10):e0186846. PMID: 29065178.
    Citations: 12     Fields:    Translation:AnimalsCells
  16. He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M. Large G protein a-subunit XLas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9559-E9568. PMID: 29078380.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. Corrigendum: SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2017 02 22; 8:14745. PMID: 28224982.
    Citations:    Fields:    
  18. Kim SW, Lu Y, Williams EA, Lai F, Lee JY, Enishi T, Balani DH, Ominsky MS, Ke HZ, Kronenberg HM, Wein MN. Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts. J Bone Miner Res. 2017 May; 32(5):892-901. PMID: 27862326.
    Citations: 29     Fields:    Translation:AnimalsCells
  19. Fulzele K, Lai F, Dedic C, Saini V, Uda Y, Shi C, Tuck P, Aronson JL, Liu X, Spatz JM, Wein MN, Divieti Pajevic P. Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots. J Bone Miner Res. 2017 Feb; 32(2):373-384. PMID: 27653320.
    Citations: 22     Fields:    Translation:AnimalsCells
  20. Greenblatt MB, Tsai JN, Wein MN. Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease. Clin Chem. 2017 Feb; 63(2):464-474. PMID: 27940448.
    Citations: 41     Fields:    Translation:Humans
  21. Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016 10 19; 7:13176. PMID: 27759007.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  22. Wasfy JH, Rao SK, Essien UR, Richardson CA, Jeune T, Goldstein SA, Laikhter E, Chittle MD, Weil M, Wein M, Ferris TG. Initial experience with endocrinology e-consults. Endocrine. 2017 Feb; 55(2):640-642. PMID: 27507674.
    Citations:    Fields:    Translation:Humans
  23. Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS. Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease. J Bone Miner Res. 2016 06; 31(6):1225-34. PMID: 26763740.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  24. Papaioannou G, Mirzamohammadi F, Lisse TS, Nishimori S, Wein MN, Kobayashi T. MicroRNA-140 Provides Robustness to the Regulation of Hypertrophic Chondrocyte Differentiation by the PTHrP-HDAC4 Pathway. J Bone Miner Res. 2015 Jun; 30(6):1044-52. PMID: 25529628.
    Citations: 19     Fields:    Translation:AnimalsCells
  25. Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD. The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro. J Biol Chem. 2015 Jul 03; 290(27):16744-58. PMID: 25953900.
    Citations: 84     Fields:    Translation:AnimalsCells
  26. Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM. HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J Bone Miner Res. 2015 Mar; 30(3):400-11. PMID: 25271055.
    Citations: 53     Fields:    Translation:AnimalsCells
  27. Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 2013 Sep; 123(9):4010-22. PMID: 23945236.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  28. Wein MN, Jones DC, Shim JH, Aliprantis AO, Sulyanto R, Lazarevic V, Poliachik SL, Gross TS, Glimcher LH. Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8173-8. PMID: 22573816.
    Citations: 16     Fields:    Translation:AnimalsCells
  29. Jones DC, Schweitzer MN, Wein M, Sigrist K, Takagi T, Ishii S, Glimcher LH. Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8254-8. PMID: 20404140.
    Citations: 11     Fields:    Translation:Animals
  30. Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest. 2008 Feb; 118(2):491-504. PMID: 18219387.
    Citations: 77     Fields:    Translation:AnimalsCells
  31. Wein MN, Jones DC, Glimcher LH. Lentivirus delivery of shRNA constructs into osteoblasts. Methods Mol Biol. 2008; 455:149-55. PMID: 18463817.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  32. Glimcher LH, Jones DC, Wein MN. Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3. Ann N Y Acad Sci. 2007 Nov; 1116:174-81. PMID: 18083927.
    Citations: 7     Fields:    Translation:Animals
  33. Jones DC, Wein MN, Glimcher LH. Schnurri-3 is an essential regulator of osteoblast function and adult bone mass. Ann Rheum Dis. 2007 Nov; 66 Suppl 3:iii49-51. PMID: 17934096.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  34. Jones DC, Wein MN, Glimcher LH. Schnurri-3: a key regulator of postnatal skeletal remodeling. Adv Exp Med Biol. 2007; 602:1-13. PMID: 17966382.
    Citations: 7     Fields:    Translation:AnimalsCells
  35. Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science. 2006 May 26; 312(5777):1223-7. PMID: 16728642.
    Citations: 92     Fields:    Translation:AnimalsCells
  36. Wein MN, Jones DC, Glimcher LH. Turning down the system: counter-regulatory mechanisms in bone and adaptive immunity. Immunol Rev. 2005 Dec; 208:66-79. PMID: 16313341.
    Citations:    Fields:    Translation:HumansAnimalsCells
  37. Oukka M, Wein MN, Glimcher LH. Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells. J Exp Med. 2004 Jan 05; 199(1):15-24. PMID: 14707112.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  38. Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, Neve RL, Lester HA, Simon MI, Nestler EJ. RGS9 modulates dopamine signaling in the basal ganglia. Neuron. 2003 Jun 19; 38(6):941-52. PMID: 12818179.
    Citations: 104     Fields:    Translation:AnimalsCells
  39. Haberstock-Debic H, Wein M, Barrot M, Colago EE, Rahman Z, Neve RL, Pickel VM, Nestler EJ, von Zastrow M, Svingos AL. Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons. J Neurosci. 2003 May 15; 23(10):4324-32. PMID: 12764121.
    Citations: 50     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.