Harvard Catalyst Profiles

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Kevin Carl Eggan, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI135423 (EGGAN, KEVIN C) Jul 1, 2018 - Jun 30, 2021
    NIH
    CRISPR/Cas9 based antivirals for treatment of latent and lytic Herpesvirus-1 and -2 infection in vivo
    Role: Principal Investigator
  2. U01MH115727 (MCCARROLL, STEVEN ANDREW) Sep 20, 2017 - Jul 31, 2022
    NIH
    Genetic neuroscience: How human genes and alleles shape neuronal phenotypes
    Role: Co-Principal Investigator
  3. R01MH109978 (KELLIS, MANOLIS) May 1, 2016 - Feb 28, 2021
    NIH
    Network-based prediction and validation of causal schizophrenia genes and variants
    Role: Co-Principal Investigator
  4. R01NS089742 (EGGAN, KEVIN C) Sep 15, 2014 - Jun 30, 2020
    NIH
    C9ORF72 in Motor System Biology and ALS
    Role: Principal Investigator
  5. U24NS078736 (ROTHSTEIN, JEFFREY D) Jul 1, 2012 - Jun 30, 2016
    NIH
    Generation and Characterization of Amyotrophic Lateral Sclerosis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Klim JR, Pintacuda G, Nash LA, Guerra San Juan I, Eggan K. Connecting TDP-43 Pathology with Neuropathy. Trends Neurosci. 2021 Apr 05. PMID: 33832769.
    Citations:    Fields:    
  2. Pintacuda G, Martín JM, Eggan KC. Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets. Mol Autism. 2021 02 08; 12(1):10. PMID: 33557935.
    Citations:    Fields:    
  3. Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, Simmons Z, Pothier L, Kassis SB, La T, Hall M, Evora A, Klements D, Hurtado A, Pereira JD, Koh J, Celnik PA, Chaudhry V, Gable K, Juel VC, Phielipp N, Marei A, Rosenquist P, Meehan S, Oskarsson B, Lewis RA, Kaur D, Kiskinis E, Woolf CJ, Eggan K, Weiss MD, Berry JD, David WS, Davila-Perez P, Camprodon JA, Pascual-Leone A, Kiernan MC, Shefner JM, Atassi N, Cudkowicz ME. Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. JAMA Neurol. 2021 Feb 01; 78(2):186-196. PMID: 33226425.
    Citations: 3     Fields:    
  4. Avior Y, Lezmi E, Eggan K, Benvenisty N. Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells. Cell Stem Cell. 2021 Jan 07; 28(1):10-11. PMID: 33321073.
    Citations: 1     Fields:    
  5. Avior Y, Eggan K, Benvenisty N. Retraction Notice to: Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. Cell Stem Cell. 2021 01 07; 28(1):173. PMID: 33433329.
    Citations: 1     Fields:    
  6. Mordes DA, Morrison BM, Ament XH, Cantrell C, Mok J, Eggan P, Xue C, Wang JY, Eggan K, Rothstein JD. Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice. Neuron. 2020 11 25; 108(4):775-783.e4. PMID: 33022228.
    Citations:    Fields:    Translation:AnimalsCells
  7. Neuhausser WM, Oh HS, Eggan P, Angelova M, Kirchner R, Eggan KC, Knipe DM. Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus. Bio Protoc. 2020 Sep 05; 10(17):e3748. PMID: 33659408.
    Citations:    
  8. Burberry A, Wells MF, Limone F, Couto A, Smith KS, Keaney J, Gillet G, van Gastel N, Wang JY, Pietilainen O, Qian M, Eggan P, Cantrell C, Mok J, Kadiu I, Scadden DT, Eggan K. C9orf72 suppresses systemic and neural inflammation induced by gut bacteria. Nature. 2020 06; 582(7810):89-94. PMID: 32483373.
    Citations: 18     Fields:    Translation:AnimalsCells
  9. Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Khleifat AA, Mordes DA, Ghosh S, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat Neurosci. 2020 Feb; 23(2):295. PMID: 31857710.
    Citations: 2     Fields:    
  10. Hazelbaker DZ, Beccard A, Angelini G, Mazzucato P, Messana A, Lam D, Eggan K, Barrett LE. A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells. Sci Rep. 2020 01 20; 10(1):635. PMID: 31959800.
    Citations: 3     Fields:    Translation:HumansCells
  11. Oh HS, Neuhausser WM, Eggan P, Angelova M, Kirchner R, Eggan KC, Knipe DM. Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9. Elife. 2019 12 02; 8. PMID: 31789594.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  12. Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM. Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nat Neurosci. 2019 12; 22(12):1966-1974. PMID: 31768050.
    Citations: 18     Fields:    Translation:Humans
  13. Groff AF, Resetkova N, DiDomenico F, Sakkas D, Penzias A, Rinn JL, Eggan K. RNA-seq as a tool for evaluating human embryo competence. Genome Res. 2019 10; 29(10):1705-1718. PMID: 31548358.
    Citations: 3     Fields:    Translation:Humans
  14. Avior Y, Eggan K, Benvenisty N. Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. Cell Stem Cell. 2019 Oct 03; 25(4):456-461. PMID: 31543368.
    Citations: 6     Fields:    Translation:HumansCells
  15. Shlevkov E, Basu H, Bray MA, Sun Z, Wei W, Apaydin K, Karhohs K, Chen PF, Smith JLM, Wiskow O, Roet K, Huang X, Eggan K, Carpenter AE, Kleiman RJ, Schwarz TL. A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell Rep. 2019 Sep 17; 28(12):3224-3237.e5. PMID: 31533043.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Mukherjee-Clavin B, Mi R, Kern B, Choi IY, Lim H, Oh Y, Lannon B, Kim KJ, Bell S, Hur JK, Hwang W, Che YH, Habib O, Baloh RH, Eggan K, Brandacher G, Hoke A, Studer L, Kim YJ, Lee G. Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder. Nat Biomed Eng. 2019 07; 3(7):571-582. PMID: 30962586.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci. 2019 02; 22(2):229-242. PMID: 30664768.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  18. Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. 2019 02; 22(2):167-179. PMID: 30643292.
    Citations: 48     Fields:    Translation:HumansCells
  19. Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K. Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development. 2018 11 21; 145(22). PMID: 30337375.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Srikanth P, Lagomarsino VN, Pearse RV, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Transl Psychiatry. 2018 11 08; 8(1):245. PMID: 30410030.
    Citations: 4     Fields:    Translation:HumansCells
  21. McPhie DL, Nehme R, Ravichandran C, Babb SM, Ghosh SD, Staskus A, Kalinowski A, Kaur R, Douvaras P, Du F, Ongur D, Fossati V, Eggan K, Cohen BM. Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Transl Psychiatry. 2018 10 23; 8(1):230. PMID: 30352993.
    Citations: 11     Fields:    Translation:HumansCells
  22. Thams S, Lowry ER, Larraufie MH, Spiller KJ, Li H, Williams DJ, Hoang P, Jiang E, Williams LA, Sandoe J, Eggan K, Lieberam I, Kanning KC, Stockwell BR, Henderson CE, Wichterle H. A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress. Mol Ther. 2019 01 02; 27(1):87-101. PMID: 30446391.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  23. Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 2018 10; 15(10):823-831. PMID: 30275587.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  24. Maas K, Mirabal S, Penzias A, Sweetnam PM, Eggan KC, Sakkas D. Hippo signaling in the ovary and polycystic ovarian syndrome. J Assist Reprod Genet. 2018 Oct; 35(10):1763-1771. PMID: 30120633.
    Citations: 4     Fields:    Translation:HumansCells
  25. Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathol Commun. 2018 07 04; 6(1):55. PMID: 29973287.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  26. Sanders SJ, Neale BM, Huang H, Werling DM, An JY, Dong S, Abecasis G, Arguello PA, Blangero J, Boehnke M, Daly MJ, Eggan K, Geschwind DH, Glahn DC, Goldstein DB, Gur RE, Handsaker RE, McCarroll SA, Ophoff RA, Palotie A, Pato CN, Sabatti C, State MW, Willsey AJ, Hyman SE, Addington AM, Lehner T, Freimer NB. Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat Neurosci. 2018 Jul; 21(7):1017. PMID: 29549319.
    Citations: 1     Fields:    
  27. Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K. The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes Dev. 2018 07 01; 32(13-14):929-943. PMID: 29950492.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  28. Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W, Floss T, Huber AB, Taylor V. TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Sci Rep. 2018 05 25; 8(1):8097. PMID: 29802307.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  29. Nehme R, Zuccaro E, Ghosh SD, Li C, Sherwood JL, Pietilainen O, Barrett LE, Limone F, Worringer KA, Kommineni S, Zang Y, Cacchiarelli D, Meissner A, Adolfsson R, Haggarty S, Madison J, Muller M, Arlotta P, Fu Z, Feng G, Eggan K. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 2018 05 22; 23(8):2509-2523. PMID: 29791859.
    Citations: 38     Fields:    Translation:HumansCells
  30. Kiskinis E, Kralj JM, Zou P, Weinstein EN, Zhang H, Tsioras K, Wiskow O, Ortega JA, Eggan K, Cohen AE. All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS. Stem Cell Reports. 2018 06 05; 10(6):1991-2004. PMID: 29779896.
    Citations: 11     Fields:    Translation:HumansCells
  31. Sanders SJ, Neale BM, Huang H, Werling DM, An JY, Dong S, Abecasis G, Arguello PA, Blangero J, Boehnke M, Daly MJ, Eggan K, Geschwind DH, Glahn DC, Goldstein DB, Gur RE, Handsaker RE, McCarroll SA, Ophoff RA, Palotie A, Pato CN, Sabatti C, State MW, Willsey AJ, Hyman SE, Addington AM, Lehner T, Freimer NB. Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat Neurosci. 2017 12; 20(12):1661-1668. PMID: 29184211.
    Citations: 26     Fields:    Translation:Humans
  32. Kawada J, Kaneda S, Kirihara T, Maroof A, Levi T, Eggan K, Fujii T, Ikeuchi Y. Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons. Stem Cell Reports. 2017 11 14; 9(5):1441-1449. PMID: 29107592.
    Citations: 19     Fields:    Translation:HumansCells
  33. Hazelbaker DZ, Beccard A, Bara AM, Dabkowski N, Messana A, Mazzucato P, Lam D, Manning D, Eggan K, Barrett LE. A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease. Stem Cell Reports. 2017 10 10; 9(4):1315-1327. PMID: 29020615.
    Citations: 2     Fields:    Translation:HumansCells
  34. Salick MR, Wells MF, Eggan K, Kaykas A. Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids. J Vis Exp. 2017 09 19; (127). PMID: 28994790.
    Citations: 6     Fields:    Translation:HumansCells
  35. Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-ß1. Stem Cell Reports. 2017 08 08; 9(2):667-680. PMID: 28712846.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  36. Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN. Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem Cell Reports. 2017 07 11; 9(1):1-4. PMID: 28700896.
    Citations: 14     Fields:    Translation:HumansCells
  37. Merkle FT, Ghosh S, Kamitaki N, Mitchell J, Avior Y, Mello C, Kashin S, Mekhoubad S, Ilic D, Charlton M, Saphier G, Handsaker RE, Genovese G, Bar S, Benvenisty N, McCarroll SA, Eggan K. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature. 2017 05 11; 545(7653):229-233. PMID: 28445466.
    Citations: 107     Fields:    Translation:HumansCells
  38. Wells MF, Salick MR, Wiskow O, Ho DJ, Worringer KA, Ihry RJ, Kommineni S, Bilican B, Klim JR, Hill EJ, Kane LT, Ye C, Kaykas A, Eggan K. Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell Stem Cell. 2016 12 01; 19(6):703-708. PMID: 27912091.
    Citations: 85     Fields:    Translation:HumansCells
  39. Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7701-E7709. PMID: 27849576.
    Citations: 44     Fields:    Translation:HumansCells
  40. Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS, Eggan K. Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nat Commun. 2016 10 31; 7:13283. PMID: 27796305.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  41. Herring A, Messana A, Bara AM, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016 09; 17(2):430-432. PMID: 27879218.
    Citations: 1     Fields:    Translation:HumansCells
  42. Bara AM, Messana A, Herring A, Hazelbaker DZ, Eggan K, Barrett LE. Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem Cell Res. 2016 09; 17(2):441-443. PMID: 27879221.
    Citations: 3     Fields:    Translation:HumansCells
  43. Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016 08 17; 38:5B.6.1-5B.6.60. PMID: 27532820.
    Citations: 10     Fields:    Translation:HumansCells
  44. Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. PMID: 27412785.
    Citations: 74     Fields:    Translation:Animals
  45. Ray MK, Wiskow O, King MJ, Ismail N, Ergun A, Wang Y, Plys AJ, Davis CP, Kathrein K, Sadreyev R, Borowsky ML, Eggan K, Zon L, Galloway JL, Kingston RE. CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016 09 09; 291(37):19558-72. PMID: 27405765.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  46. Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016 Apr; 19(4):542-53. PMID: 27021939.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  47. Intoh A, Suzuki N, Koszka K, Eggan K. SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation. Hum Mol Genet. 2016 05 01; 25(9):1814-23. PMID: 26976849.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  48. Paull D, Sevilla A, Zhou H, Hahn AK, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard CM, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz DN, Martinez H, Malicdan MC, Weiss KA, Vensand LB, Dusenberry CR, Polus H, Sy KT, Kahler DJ, Gahl WA, Solomon SL, Chang S, Meissner A, Eggan K, Noggle SA. Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat Methods. 2015 Sep; 12(9):885-92. PMID: 26237226.
    Citations: 68     Fields:    Translation:HumansCells
  49. McNeish J, Gardner JP, Wainger BJ, Woolf CJ, Eggan K. From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell Stem Cell. 2015 Jul 02; 17(1):8-10. PMID: 26140603.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  50. Merkle FT, Neuhausser WM, Santos D, Valen E, Gagnon JA, Maas K, Sandoe J, Schier AF, Eggan K. Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus. Cell Rep. 2015 May 12; 11(6):875-883. PMID: 25937281.
    Citations: 49     Fields:    Translation:HumansCells
  51. Schwarz-Romond T, Kiskinis E, Eggan K. Focus on induced pluripotency and cellular reprogramming. EMBO J. 2015 Jun 03; 34(11):1435. PMID: 25916828.
    Citations:    Fields:    Translation:HumansAnimalsCells
  52. Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development. 2015 Feb 15; 142(4):633-43. PMID: 25670790.
    Citations: 38     Fields:    Translation:HumansCells
  53. Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015 Jan 27; 6:6171. PMID: 25625564.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  54. Toma JS, Shettar BC, Chipman PH, Pinto DM, Borowska JP, Ichida JK, Fawcett JP, Zhang Y, Eggan K, Rafuse VF. Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. J Neurosci. 2015 Jan 21; 35(3):1291-306. PMID: 25609642.
    Citations: 24     Fields:    Translation:AnimalsCells
  55. de Boer AS, Eggan K. A perspective on stem cell modeling of amyotrophic lateral sclerosis. Cell Cycle. 2015; 14(23):3679-88. PMID: 26505672.
    Citations: 7     Fields:    Translation:HumansCells
  56. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. PMID: 25420066.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  57. Fukuda A, Tomikawa J, Miura T, Hata K, Nakabayashi K, Eggan K, Akutsu H, Umezawa A. The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice. Nat Commun. 2014 Nov 14; 5:5464. PMID: 25394724.
    Citations: 23     Fields:    Translation:AnimalsCells
  58. Koren A, Handsaker RE, Kamitaki N, Karlic R, Ghosh S, Polak P, Eggan K, McCarroll SA. Genetic variation in human DNA replication timing. Cell. 2014 Nov 20; 159(5):1015-1026. PMID: 25416942.
    Citations: 51     Fields:    Translation:HumansCells
  59. Ichida JK, W JT, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Erratum: Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Nov 13; 10(12):1074. PMID: 25393496.
    Citations:    
  60. Ichida JK, W JT, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Erratum: Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Nov 13; 10(12):1074. PMID: 25393494.
    Citations:    
  61. Woodard CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M, Mosharov EV, Sulzer D, Zhou H, Paull D, Clark L, Schadt EE, Sardi SP, Rubin L, Eggan K, Brock M, Lipnick S, Rao M, Chang S, Li A, Noggle SA. iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell Rep. 2014 Nov 20; 9(4):1173-82. PMID: 25456120.
    Citations: 85     Fields:    Translation:HumansCells
  62. de Boer AS, Koszka K, Kiskinis E, Suzuki N, Davis-Dusenbery BN, Eggan K. Genetic validation of a therapeutic target in a mouse model of ALS. Sci Transl Med. 2014 Aug 06; 6(248):248ra104. PMID: 25100738.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  63. Smith ZD, Chan MM, Humm KC, Karnik R, Mekhoubad S, Regev A, Eggan K, Meissner A. DNA methylation dynamics of the human preimplantation embryo. Nature. 2014 Jul 31; 511(7511):611-5. PMID: 25079558.
    Citations: 186     Fields:    Translation:HumansAnimalsCells
  64. Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR. FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Mol Biol Cell. 2014 Sep 01; 25(17):2571-8. PMID: 25009283.
    Citations: 26     Fields:    Translation:HumansCells
  65. Ichida JK, Tcw J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug; 10(8):632-639. PMID: 24952596.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  66. Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K. Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicol Teratol. 2014 May-Jun; 43:59-68. PMID: 24746641.
    Citations: 4     Fields:    Translation:AnimalsCells
  67. Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 05; 14(6):781-95. PMID: 24704492.
    Citations: 155     Fields:    Translation:HumansCells
  68. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10; 7(1):1-11. PMID: 24703839.
    Citations: 203     Fields:    Translation:HumansCells
  69. Haidet-Phillips AM, Roybon L, Gross SK, Tuteja A, Donnelly CJ, Richard JP, Ko M, Sherman A, Eggan K, Henderson CE, Maragakis NJ. Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem Cells Transl Med. 2014 May; 3(5):575-85. PMID: 24604284.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  70. Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SSW, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 2014 Feb 05; 81(3):536-543. PMID: 24507191.
    Citations: 214     Fields:    Translation:HumansAnimalsCells
  71. Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K. How to make spinal motor neurons. Development. 2014 Feb; 141(3):491-501. PMID: 24449832.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  72. Carter AC, Davis-Dusenbery BN, Koszka K, Ichida JK, Eggan K. Nanog-independent reprogramming to iPSCs with canonical factors. Stem Cell Reports. 2014 Feb 11; 2(2):119-26. PMID: 24527385.
    Citations: 20     Fields:    Translation:AnimalsCells
  73. Eggan K. Picking the lock on pluripotency. N Engl J Med. 2013 Nov 28; 369(22):2150-1. PMID: 24283230.
    Citations:    Fields:    Translation:HumansAnimalsCells
  74. Navara CS, Hornecker J, Grow D, Chaudhari S, Hornsby PJ, Ichida JK, Eggan K, McCarrey JR. Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cell Reprogram. 2013 Dec; 15(6):495-502. PMID: 24182315.
    Citations: 8     Fields:    Translation:AnimalsCells
  75. Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I, Moccia R, Davis-Dusenbery BN, Eggan K. The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD. Nat Neurosci. 2013 Dec; 16(12):1725-7. PMID: 24185425.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  76. Sandoe J, Eggan K. Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nat Neurosci. 2013 Jul; 16(7):780-9. PMID: 23799470.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  77. Merkle FT, Eggan K. Modeling human disease with pluripotent stem cells: from genome association to function. Cell Stem Cell. 2013 Jun 06; 12(6):656-68. PMID: 23746975.
    Citations: 80     Fields:    Translation:HumansCells
  78. Maroof AM, Keros S, Tyson JA, Ying SW, Ganat YM, Merkle FT, Liu B, Goulburn A, Stanley EG, Elefanty AG, Widmer HR, Eggan K, Goldstein PA, Anderson SA, Studer L. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell. 2013 May 02; 12(5):559-72. PMID: 23642365.
    Citations: 226     Fields:    Translation:HumansAnimalsCells
  79. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80. PMID: 23474986.
    Citations: 86     Fields:    Translation:AnimalsCells
  80. Niakan KK, Eggan K. Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse. Dev Biol. 2013 Mar 01; 375(1):54-64. PMID: 23261930.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  81. Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K. Developmental bias in cleavage-stage mouse blastomeres. Curr Biol. 2013 Jan 07; 23(1):21-31. PMID: 23177476.
    Citations: 38     Fields:    Translation:AnimalsCells
  82. Williams LA, Davis-Dusenbery BN, Eggan KC. SnapShot: directed differentiation of pluripotent stem cells. Cell. 2012 May 25; 149(5):1174-1174.e1. PMID: 22632979.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  83. Mekhoubad S, Bock C, de Boer AS, Kiskinis E, Meissner A, Eggan K. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell. 2012 May 04; 10(5):595-609. PMID: 22560080.
    Citations: 136     Fields:    Translation:HumansCells
  84. Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun. 2011 Oct 04; 2:488. PMID: 21971503.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  85. Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K. Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell. 2011 Oct 04; 9(4):293-4. PMID: 21982228.
    Citations: 10     Fields:    Translation:Humans
  86. Seandel M, Eggan K. Stem Cells: Doing Some Heavy Lifting at ISSCR 2011. Cell Stem Cell. 2011 Oct 4; 9(4):311-5. PMID: 21982231.
    Citations:    
  87. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 02; 9(3):205-18. PMID: 21852222.
    Citations: 289     Fields:    Translation:HumansAnimalsCells
  88. Han SS, Williams LA, Eggan KC. Constructing and deconstructing stem cell models of neurological disease. Neuron. 2011 May 26; 70(4):626-44. PMID: 21609821.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  89. Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):63-7. PMID: 21368825.
    Citations: 510     Fields:    Translation:HumansCells
  90. Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K, Meissner A. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell. 2011 Feb 04; 144(3):439-52. PMID: 21295703.
    Citations: 412     Fields:    Translation:HumansCells
  91. Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K. A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol. 2011 Mar; 29(3):279-86. PMID: 21293464.
    Citations: 214     Fields:    Translation:HumansCells
  92. Ichida JK, Kiskinis E, Eggan K. Shushing down the epigenetic landscape towards stem cell differentiation. Development. 2010 Aug 01; 137(15):2455-60. PMID: 20554719.
    Citations:    Fields:    Translation:HumansAnimalsCells
  93. Egli D, Eggan K. Recipient cell nuclear factors are required for reprogramming by nuclear transfer. Development. 2010 Jun; 137(12):1953-63. PMID: 20463036.
    Citations: 12     Fields:    Translation:AnimalsCells
  94. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010 Feb 01; 24(3):312-26. PMID: 20123909.
    Citations: 122     Fields:    Translation:AnimalsCells
  95. Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest. 2010 Jan; 120(1):51-9. PMID: 20051636.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  96. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 06; 5(5):491-503. PMID: 19818703.
    Citations: 310     Fields:    Translation:AnimalsCells
  97. Egli D, Sandler VM, Shinohara ML, Cantor H, Eggan K. Reprogramming after chromosome transfer into mouse blastomeres. Curr Biol. 2009 Aug 25; 19(16):1403-9. PMID: 19682906.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  98. Zhang K, Li JB, Gao Y, Egli D, Xie B, Deng J, Li Z, Lee JH, Aach J, Leproust EM, Eggan K, Church GM. Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nat Methods. 2009 Aug; 6(8):613-8. PMID: 19620972.
    Citations: 89     Fields:    Translation:HumansCells
  99. Deng J, Shoemaker R, Xie B, Gore A, LeProust EM, Antosiewicz-Bourget J, Egli D, Maherali N, Park IH, Yu J, Daley GQ, Eggan K, Hochedlinger K, Thomson J, Wang W, Gao Y, Zhang K. Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol. 2009 Apr; 27(4):353-60. PMID: 19330000.
    Citations: 215     Fields:    Translation:HumansCells
  100. Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 2009 Feb 06; 4(2):103-6. PMID: 19200798.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  101. Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell. 2008 Dec 04; 3(6):637-48. PMID: 19041780.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
  102. Eggan K. Using stem cells and reprogramming to understand disease. Regen Med. 2008 Nov; 3(6):799-801. PMID: 18947303.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  103. Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science. 2008 Aug 29; 321(5893):1218-21. PMID: 18669821.
    Citations: 719     Fields:    Translation:HumansCells
  104. Egli D, Birkhoff G, Eggan K. Mediators of reprogramming: transcription factors and transitions through mitosis. Nat Rev Mol Cell Biol. 2008 Jul; 9(7):505-16. PMID: 18568039.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  105. Eggan K. Short-circuiting epiblast development. Cell Stem Cell. 2007 Aug 16; 1(2):131-2. PMID: 18371343.
    Citations:    Fields:    Translation:HumansAnimalsCells
  106. Egli D, Rosains J, Birkhoff G, Eggan K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature. 2007 Jun 07; 447(7145):679-85. PMID: 17554301.
    Citations: 83     Fields:    Translation:AnimalsCells
  107. Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci. 2007 May; 10(5):608-14. PMID: 17435754.
    Citations: 325     Fields:    Translation:HumansAnimalsCells
  108. Eggan K. Dolly's legacy: human nuclear transplantation and better medicines for our children. . 2007; 9(1):21-5. PMID: 17386009.
    Citations:    Translation:HumansAnimalsCells
  109. Egli D, Eggan K. Nuclear transfer into mouse oocytes. J Vis Exp. 2006 Nov 30; (1):116. PMID: 18704178.
    Citations: 5     Fields:    Translation:AnimalsCells
  110. Trish E, Dimos J, Eggan K. Human ES cells: starting culture from frozen cells. J Vis Exp. 2006 Nov 09; (1):86. PMID: 18704174.
    Citations:    Fields:    Translation:HumansAnimalsCells
  111. Trish E, Dimos J, Eggan K. Passaging HuES human embryonic stem cell-lines with trypsin. J Vis Exp. 2006 Oct 12; (1):49. PMID: 18704181.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  112. Trish E, Dimos J, Eggan K. Freezing human ES cells. J Vis Exp. 2006 Oct 12; (1):50. PMID: 18704182.
    Citations:    Fields:    Translation:HumansCells
  113. Rodolfa KT, Eggan K. A transcriptional logic for nuclear reprogramming. Cell. 2006 Aug 25; 126(4):652-5. PMID: 16923385.
    Citations: 8     Fields:    Translation:AnimalsCells
  114. Eggan K, Jurga S, Gosden R, Min IM, Wagers AJ. Ovulated oocytes in adult mice derive from non-circulating germ cells. Nature. 2006 Jun 29; 441(7097):1109-14. PMID: 16799565.
    Citations: 68     Fields:    Translation:AnimalsCells
  115. Yang X, Eggan K, Seidel G, Jaenisch R, Melton D. A simple system of checks and balances to cut fraud. Nature. 2006 Feb 16; 439(7078):782. PMID: 16482128.
    Citations:    Fields:    Translation:HumansCells
  116. Sullivan S, Eggan K. The potential of cell fusion for human therapy. Stem Cell Rev. 2006; 2(4):341-9. PMID: 17848721.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  117. Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science. 2005 Aug 26; 309(5739):1369-73. PMID: 16123299.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  118. Jaenisch R, Hochedlinger K, Eggan K. Nuclear cloning, epigenetic reprogramming and cellular differentiation. Novartis Found Symp. 2005; 265:107-18; discussion 118-28. PMID: 16050253.
    Citations: 1     Fields:    Translation:AnimalsCells
  119. Eggan K, Baldwin K, Tackett M, Osborne J, Gogos J, Chess A, Axel R, Jaenisch R. Mice cloned from olfactory sensory neurons. Nature. 2004 Mar 04; 428(6978):44-9. PMID: 14990966.
    Citations: 102     Fields:    Translation:AnimalsCells
  120. Jaenisch R, Hochedlinger K, Blelloch R, Yamada Y, Baldwin K, Eggan K. Nuclear cloning, epigenetic reprogramming, and cellular differentiation. Cold Spring Harb Symp Quant Biol. 2004; 69:19-27. PMID: 16117629.
    Citations: 9     Fields:    Translation:AnimalsCells
  121. Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ. Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature. 2004 Jan 08; 427(6970):148-54. PMID: 14668819.
    Citations: 181     Fields:    Translation:AnimalsCells
  122. Eggan K, Jaenisch R. Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation. Semin Cell Dev Biol. 2003 Dec; 14(6):349-58. PMID: 15015742.
    Citations:    Fields:    Translation:AnimalsCells
  123. Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003 Apr; 130(8):1673-80. PMID: 12620990.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  124. Eggan K, Jaenisch R. Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Methods Enzymol. 2003; 365:25-39. PMID: 14696335.
    Citations: 6     Fields:    Translation:Animals
  125. Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12889-94. PMID: 12235366.
    Citations: 79     Fields:    Translation:AnimalsCells
  126. Eggan K, Rode A, Jentsch I, Samuel C, Hennek T, Tintrup H, Zevnik B, Erwin J, Loring J, Jackson-Grusby L, Speicher MR, Kuehn R, Jaenisch R. Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nat Biotechnol. 2002 May; 20(5):455-9. PMID: 11981557.
    Citations: 31     Fields:    Translation:AnimalsCells
  127. Biniszkiewicz D, Gribnau J, Ramsahoye B, Gaudet F, Eggan K, Humpherys D, Mastrangelo MA, Jun Z, Walter J, Jaenisch R. Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol. 2002 Apr; 22(7):2124-35. PMID: 11884600.
    Citations: 83     Fields:    Translation:AnimalsCells
  128. Possemato R, Eggan K, Moeller BJ, Jaenisch R, Jackson-Grusby L. Flp recombinase regulated lacZ expression at the ROSA26 locus. Genesis. 2002 Feb; 32(2):184-6. PMID: 11857816.
    Citations: 2     Fields:    Translation:Animals
  129. Jeanisch R, Eggan K, Humpherys D, Rideout W, Hochedlinger K. Nuclear cloning, stem cells, and genomic reprogramming. . 2002; 4(4):389-96. PMID: 12630413.
    Citations: 11     Translation:AnimalsCells
  130. Rideout WM, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science. 2001 Aug 10; 293(5532):1093-8. PMID: 11498580.
    Citations: 129     Fields:    Translation:AnimalsCells
  131. Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM, Biniszkiewicz D, Yanagimachi R, Jaenisch R. Epigenetic instability in ES cells and cloned mice. Science. 2001 Jul 06; 293(5527):95-7. PMID: 11441181.
    Citations: 135     Fields:    Translation:AnimalsCells
  132. Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WM, Yanagimachi R, Jaenisch R. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6209-14. PMID: 11331774.
    Citations: 175     Fields:    Translation:AnimalsCells
  133. Eggan K, Akutsu H, Hochedlinger K, Rideout W, Yanagimachi R, Jaenisch R. X-Chromosome inactivation in cloned mouse embryos. Science. 2000 Nov 24; 290(5496):1578-81. PMID: 11090356.
    Citations: 47     Fields:    Translation:AnimalsCells
  134. Rideout WM, Wakayama T, Wutz A, Eggan K, Jackson-Grusby L, Dausman J, Yanagimachi R, Jaenisch R. Generation of mice from wild-type and targeted ES cells by nuclear cloning. Nat Genet. 2000 Feb; 24(2):109-10. PMID: 10655052.
    Citations: 57     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.