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Samir Mukund Parikh, M.D.

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1993 - 1997
John Harvard Scholarship
Magna Cum Laude
President, Vanderbilt Chapter Alpha Omega Alpha
Founder's Medal,Vanderbilt Class of 2001
Kaufman Prize for Humanism in Medicine
Resident Teaching Award, HMS
Klarman Family Scholar
Junior Investigator Award, Amgen
Carl Gottschalk Award, American Society of Nephrology
Excellence in Tutoring, HMS
Klarman Family Scholar
Rising Stars of Research, BIDMC
Basic Science Award, ADA
Gordon Strewler Research Mentorship Award, BIDMC
Editorial Board, JASN
American Society for Clinical Investigation (ASCI)
Outstanding Investigator Award, NHLBI
Sir William Osler Award, ICC
Interurban Clinical Club (ICC)
Donald Seldin Award, American Society of Nephrology

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35HL139424 (PARIKH, SAMIR M) Jan 16, 2018 - Dec 31, 2024
    Tie2-driven vascular control in critical illness
    Role: Principal Investigator
  2. R01HL125275 (FLAUMENHAFT, ROBERT C) Sep 15, 2014 - May 31, 2019
    Targeting the Endothelium in Sepsis
    Role: Co-Principal Investigator
  3. R01DK095072 (PARIKH, SAMIR M) Sep 27, 2012 - Jun 30, 2021
    Mitochondrial biogenesis in kidney disease
    Role: Principal Investigator
  4. R01HL093234 (PARIKH, SAMIR M) Sep 15, 2008 - May 31, 2018
    Biology of Tie2 in sepsis
    Role: Principal Investigator
  5. R01AG027002 (SHLIPAK, MICHAEL G) Sep 30, 2005 - Jul 31, 2010
    Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Clark AJ, Parikh SM. Mitochondrial Metabolism in Acute Kidney Injury. Semin Nephrol. 2020 03; 40(2):101-113. PMID: 32303274.
  2. Sack KD, Kellum JA, Parikh SM. The Angiopoietin-Tie2 Pathway in Critical Illness. Crit Care Clin. 2020 Apr; 36(2):201-216. PMID: 32172809.
  3. Gupta S, Seethapathy H, Strohbehn IA, Frigault MJ, O'Donnell EK, Jacobson CA, Motwani SS, Parikh SM, Curhan GC, Reynolds KL, Leaf DE, Sise ME. Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma. Am J Kidney Dis. 2020 Jul; 76(1):63-71. PMID: 31973908.
  4. Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Eisch AR, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM. Erratum: Author Correction: A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). Commun Biol. 2019; 2:439. PMID: 31799440.
  5. Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM. A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). Commun Biol. 2019 Oct 31; 2(1):398. PMID: 31925222.
  6. Ralto KM, Rhee EP, Parikh SM. NAD+ homeostasis in renal health and disease. Nat Rev Nephrol. 2020 02; 16(2):99-111. PMID: 31673160.
  7. Raza A, Xie Z, Chan EC, Chen WS, Scott LM, Robin Eisch A, Krementsov DN, Rosenberg HF, Parikh SM, Blankenhorn EP, Teuscher C, Druey KM. A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). Commun Biol. 2019; 2:398. PMID: 31701027.
  8. Xie Z, Kuhns DB, Gu X, Otu HH, Libermann TA, Gallin JI, Parikh SM, Druey KM. Neutrophil activation in systemic capillary leak syndrome (Clarkson disease). J Cell Mol Med. 2019 08; 23(8):5119-5127. PMID: 31210423.
  9. Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS. Author Correction: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019 Jun; 570(7759):E23. PMID: 31089212.
  10. Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM. An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metab. 2019 07 02; 30(1):190-200.e6. PMID: 31105043.
  11. Parikh SM. Metabolic Stress Resistance in Acute Kidney Injury: Evidence for a PPAR-Gamma-Coactivator-1 Alpha-Nicotinamide Adenine Dinucleotide Pathway. Nephron. 2019; 143(3):184-187. PMID: 31055583.
  12. Lynch MR, Tran MT, Ralto KM, Zsengeller ZK, Raman V, Bhasin SS, Sun N, Chen X, Brown D, Rovira II, Taguchi K, Brooks CR, Stillman IE, Bhasin MK, Finkel T, Parikh SM. TFEB-driven lysosomal biogenesis is pivotal for PGC1a-dependent renal stress resistance. JCI Insight. 2019 03 14; 5. PMID: 30870143.
  13. Allegretti AS, Vela Parada X, Ortiz GA, Long J, Krinsky S, Zhao S, Fuchs BC, Sojoodi M, Zhang D, Karumanchi SA, Kalim S, Nigwekar SU, Thadhani RI, Parikh SM, Chung RT. Serum Angiopoietin-2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis. Hepatology. 2019 02; 69(2):729-741. PMID: 30141205.
    Citations:    Fields:    
  14. Zhou HL, Zhang R, Anand P, Stomberski CT, Qian Z, Hausladen A, Wang L, Rhee EP, Parikh SM, Karumanchi SA, Stamler JS. Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019 01; 565(7737):96-100. PMID: 30487609.
    Citations:    Fields:    
  15. Parikh SM. Increased synthesis of a coenzyme linked to longevity can combat disease. Nature. 2018 11; 563(7731):332-333. PMID: 30425355.
  16. Rokhzan R, Ghosh CC, Schaible N, Notbohm J, Yoshie H, Ehrlicher AJ, Higgins SJ, Zhang R, Haller H, Hardin CC, David S, Parikh SM, Krishnan R. Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function. Lab Invest. 2019 01; 99(1):138-145. PMID: 30310180.
    Citations:    Fields:    
  17. Mahmood E, Jeganathan J, Feng R, Saraf M, Khabbaz K, Mahmood F, Venkatachalam S, Liu D, Chu L, Parikh SM, Matyal R. Decreased PGC-1a Post-Cardiopulmonary Bypass Leads to Impaired Oxidative Stress in Diabetic Patients. Ann Thorac Surg. 2019 02; 107(2):467-476. PMID: 30291832.
    Citations:    Fields:    
  18. Thamm K, Schrimpf C, Retzlaff J, Idowu TO, van Meurs M, Zijlstra JG, Ghosh CC, Zeitvogel J, Werfel TA, Haller H, Parikh SM, David S. Molecular Regulation of Acute Tie2 Suppression in Sepsis. Crit Care Med. 2018 09; 46(9):e928-e936. PMID: 29979219.
    Citations:    Fields:    
  19. Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med. 2018 09; 24(9):1351-1359. PMID: 30127395.
    Citations:    Fields:    
  20. Brown SM, Beesley SJ, Lanspa MJ, Grissom CK, Wilson EL, Parikh SM, Sarge T, Talmor D, Banner-Goodspeed V, Novack V, Thompson BT, Shahul S. Esmolol infusion in patients with septic shock and tachycardia: a prospective, single-arm, feasibility study. Pilot Feasibility Stud. 2018; 4:132. PMID: 30123523.
  21. Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM. Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest. 2018 04 02; 128(4):1471-1484. PMID: 29360642.
    Citations: 5     Fields:    
  22. Druey KM, Arai AE, Parikh SM. Reply. J Allergy Clin Immunol. 2018 04; 141(4):1540-1541. PMID: 29477580.
    Citations:    Fields:    
  23. De Ceunynck K, Peters CG, Jain A, Higgins SJ, Aisiku O, Fitch-Tewfik JL, Chaudhry SA, Dockendorff C, Parikh SM, Ingber DE, Flaumenhaft R. PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E982-E991. PMID: 29343648.
    Citations:    Fields:    Translation:HumansAnimalsCells
  24. Drury ER, Zsengeller ZK, Stillman IE, Khankin EV, Pavlakis M, Parikh SM. Renal PGC1a May Be Associated with Recovery after Delayed Graft Function. Nephron. 2018; 138(4):303-309. PMID: 29268263.
    Citations:    Fields:    
  25. Lynch MR, Tran MT, Parikh SM. PGC1a in the kidney. Am J Physiol Renal Physiol. 2018 01 01; 314(1):F1-F8. PMID: 28931521.
    Citations: 1     Fields:    
  26. Parikh SM. Angiopoietins and Tie2 in vascular inflammation. Curr Opin Hematol. 2017 Sep; 24(5):432-438. PMID: 28582314.
    Citations:    Fields:    Translation:HumansCells
  27. Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med. 2017 08 31; 377(9):839-848. PMID: 28854085.
    Citations: 20     Fields:    Translation:Humans
  28. Poyan Mehr A, Parikh SM. PPAR?-Coactivator-1a, Nicotinamide Adenine Dinucleotide and Renal Stress Resistance. Nephron. 2017; 137(4):253-255. PMID: 28591759.
    Citations:    Fields:    Translation:HumansAnimals
  29. Parikh SM. The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation. J Am Soc Nephrol. 2017 Jul; 28(7):1973-1982. PMID: 28465380.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  30. Retzlaff J, Thamm K, Ghosh CC, Ziegler W, Haller H, Parikh SM, David S. Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis. Sci Rep. 2017 03 09; 7:44113. PMID: 28276491.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  31. Sangwung P, Zhou G, Nayak L, Chan ER, Kumar S, Kang DW, Zhang R, Liao X, Lu Y, Sugi K, Fujioka H, Shi H, Lapping SD, Ghosh CC, Higgins SJ, Parikh SM, Jo H, Jain MK. KLF2 and KLF4 control endothelial identity and vascular integrity. JCI Insight. 2017 02 23; 2(4):e91700. PMID: 28239661.
    Citations: 10     Fields:    
  32. Druey KM, Parikh SM. Idiopathic systemic capillary leak syndrome (Clarkson disease). J Allergy Clin Immunol. 2017 Sep; 140(3):663-670. PMID: 28012935.
    Citations: 4     Fields:    Translation:HumansAnimals
  33. Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2016 07 28; 375(4):311-22. PMID: 27295427.
    Citations: 362     Fields:    Translation:Humans
  34. Maski MR, Thomas RJ, Karumanchi SA, Parikh SM. Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea. PLoS One. 2016; 11(5):e0154503. PMID: 27149121.
    Citations:    Fields:    Translation:Humans
  35. Parikh SM. Targeting Tie2 and the host vascular response in sepsis. Sci Transl Med. 2016 04 20; 8(335):335fs9. PMID: 27099172.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  36. Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM. PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016 Mar 24; 531(7595):528-32. PMID: 26982719.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  37. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016 Apr; 22(4):421-6. PMID: 26950361.
    Citations: 58     Fields:    Translation:HumansAnimals
  38. Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM. Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2472-7. PMID: 26884170.
    Citations: 17     Fields:    Translation:Animals
  39. Agarwal A, Dong Z, Harris R, Murray P, Parikh SM, Rosner MH, Kellum JA, Ronco C. Cellular and Molecular Mechanisms of AKI. J Am Soc Nephrol. 2016 May; 27(5):1288-99. PMID: 26860342.
    Citations: 16     Fields:    Translation:HumansAnimals
  40. Emma F, Montini G, Parikh SM, Salviati L. Mitochondrial dysfunction in inherited renal disease and acute kidney injury. Nat Rev Nephrol. 2016 May; 12(5):267-80. PMID: 26804019.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  41. Ralto KM, Parikh SM. Mitochondria in Acute Kidney Injury. Semin Nephrol. 2016 Jan; 36(1):8-16. PMID: 27085731.
    Citations: 6     Fields:    Translation:HumansCells
  42. Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM. Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med. 2015 Jul; 43(7):e230-40. PMID: 25855898.
    Citations: 10     Fields:    Translation:HumansAnimals
  43. Milam KE, Parikh SM. The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation. Tissue Barriers. 2015; 3(1-2):e957508. PMID: 25838975.
    Citations: 14     Fields:    
  44. Ghosh CC, Mukherjee A, David S, Milam KE, Hunter JT, Parikh SM. Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense. PLoS One. 2015; 10(3):e0119577. PMID: 25761062.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  45. Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood. 2015 Mar 19; 125(12):1976-85. PMID: 25587041.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  46. Parikh SM, Yang Y, He L, Tang C, Zhan M, Dong Z. Mitochondrial function and disturbances in the septic kidney. Semin Nephrol. 2015 Jan; 35(1):108-19. PMID: 25795504.
    Citations: 15     Fields:    Translation:HumansCells
  47. Thamm K, Stiehl T, Parikh SM, David S. The authors reply. Crit Care Med. 2015 Jan; 43(1):e32-3. PMID: 25514739.
    Citations:    Fields:    Translation:Animals
  48. Stiehl T, Thamm K, Kaufmann J, Schaeper U, Kirsch T, Haller H, Santel A, Ghosh CC, Parikh SM, David S. Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis. Crit Care Med. 2014 Oct; 42(10):e654-62. PMID: 25083983.
    Citations: 18     Fields:    Translation:Animals
  49. Tran M, Parikh SM. Mitochondrial biogenesis in the acutely injured kidney. Nephron Clin Pract. 2014; 127(1-4):42-5. PMID: 25343819.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  50. Matyal R, Sakamuri S, Huang T, Owais K, Parikh S, Khabbaz K, Wang A, Sellke F, Mahmood F. Oxidative stress and nerve function after cardiopulmonary bypass in patients with diabetes. Ann Thorac Surg. 2014 Nov; 98(5):1635-43; discussion 1643-4. PMID: 25258156.
    Citations: 1     Fields:    Translation:Humans
  51. Xie Z, Ghosh CC, Parikh SM, Druey KM. Mechanistic classification of the systemic capillary leak syndrome: Clarkson disease. Am J Respir Crit Care Med. 2014 May 01; 189(9):1145-7. PMID: 24787070.
    Citations: 10     Fields:    Translation:Humans
  52. Xie Z, Chan E, Yin Y, Ghosh CC, Wisch L, Nelson C, Young M, Parikh SM, Druey KM. Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease). J Clin Cell Immunol. 2014; 5:1000213. PMID: 25405070.
    Citations: 10     
  53. Parikh SM. Therapeutic targeting of the mitochondrial dysfunction in septic acute kidney injury. Curr Opin Crit Care. 2013 Dec; 19(6):554-9. PMID: 24150113.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  54. Karumanchi SA, Parikh SM. Moving forward in sepsis research. Am J Respir Crit Care Med. 2013 Nov 15; 188(10):1264-5. PMID: 24236592.
    Citations:    Fields:    Translation:HumansAnimals
  55. Maski MR, Parikh SM. The vasculature in diabetic nephropathy: all tied up? J Am Soc Nephrol. 2014 Jan; 25(1):1-3. PMID: 24115474.
    Citations:    Fields:    Translation:HumansAnimals
  56. Parikh SM. Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence. 2013 Aug 15; 4(6):517-24. PMID: 23652985.
    Citations: 21     Fields:    Translation:HumansAnimals
  57. Nigwekar SU, Bhan I, Turchin A, Skentzos SC, Hajhosseiny R, Steele D, Nazarian RM, Wenger J, Parikh S, Karumanchi A, Thadhani R. Statin use and calcific uremic arteriolopathy: a matched case-control study. Am J Nephrol. 2013; 37(4):325-32. PMID: 23548843.
    Citations: 17     Fields:    Translation:Humans
  58. Berg AH, Drechsler C, Wenger J, Buccafusca R, Hod T, Kalim S, Ramma W, Parikh SM, Steen H, Friedman DJ, Danziger J, Wanner C, Thadhani R, Karumanchi SA. Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med. 2013 Mar 06; 5(175):175ra29. PMID: 23467560.
    Citations: 30     Fields:    Translation:Humans
  59. David S, Kümpers P, van Slyke P, Parikh SM. Mending leaky blood vessels: the angiopoietin-Tie2 pathway in sepsis. J Pharmacol Exp Ther. 2013 Apr; 345(1):2-6. PMID: 23378191.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  60. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41. PMID: 22890252.
    Citations: 51     Fields:    Translation:HumansAnimals
  61. Clajus C, Lukasz A, David S, Hertel B, Lichtinghagen R, Parikh SM, Simon A, Ismail I, Haller H, Kümpers P. Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass. Cytokine. 2012 Nov; 60(2):352-9. PMID: 22770562.
    Citations: 8     Fields:    Translation:HumansCells
  62. Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM. Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10024-9. PMID: 22665799.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  63. Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem. 2012 Jul; 60(7):521-9. PMID: 22511597.
    Citations: 27     Fields:    Translation:AnimalsCells
  64. van Meurs M, Castro P, Shapiro NI, Lu S, Yano M, Maeda N, Funahashi T, Shimomura I, Zijlstra JG, Molema G, Parikh SM, Aird WC, Yano K. Adiponectin diminishes organ-specific microvascular endothelial cell activation associated with sepsis. Shock. 2012 Apr; 37(4):392-8. PMID: 22258235.
    Citations: 8     Fields:    Translation:AnimalsCells
  65. Xie Z, Ghosh CC, Patel R, Iwaki S, Gaskins D, Nelson C, Jones N, Greipp PR, Parikh SM, Druey KM. Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood. 2012 May 03; 119(18):4321-32. PMID: 22411873.
    Citations: 31     Fields:    Translation:HumansCells
  66. Rajakumar A, Cerdeira AS, Rana S, Zsengeller Z, Edmunds L, Jeyabalan A, Hubel CA, Stillman IE, Parikh SM, Karumanchi SA. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension. 2012 Feb; 59(2):256-64. PMID: 22215706.
    Citations: 35     Fields:    Translation:HumansCells
  67. Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med. 2012 Jan 15; 52(2):497-506. PMID: 22120494.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  68. David S, Ghosh CC, Mukherjee A, Parikh SM. Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2643-52. PMID: 21885850.
    Citations: 31     Fields:    Translation:HumansCells
  69. Kumpers P, Gueler F, David S, Slyke PV, Dumont DJ, Park JK, Bockmeyer CL, Parikh SM, Pavenstadt H, Haller H, Shushakova N. The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit Care. 2011; 15(5):R261. PMID: 22040774.
    Citations: 31     Fields:    Translation:Animals
  70. Parikh SM. Circulating mediators of focal segmental glomerulosclerosis: soluble urokinase plasminogen activator receptor in context. Am J Kidney Dis. 2012 Mar; 59(3):336-9. PMID: 22033283.
    Citations: 1     Fields:    
  71. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14. PMID: 21881206.
    Citations: 90     Fields:    Translation:AnimalsCells
  72. David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM. Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L851-62. PMID: 21421750.
    Citations: 34     Fields:    Translation:HumansAnimals
  73. Shapiro NI, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care. 2010; 14(5):R182. PMID: 20942957.
    Citations: 59     Fields:    Translation:HumansCells
  74. Parikh SM, Pollak MR. VEGF receptors and glomerular function. J Am Soc Nephrol. 2010 Oct; 21(10):1599-600. PMID: 20847145.
    Citations:    Fields:    Translation:AnimalsCells
  75. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 01; 185(1):517-24. PMID: 20519646.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  76. Yuan HT, Khankin EV, Karumanchi SA, Parikh SM. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol. 2009 Apr; 29(8):2011-22. PMID: 19223473.
    Citations: 101     Fields:    Translation:HumansCells
  77. Parikh SM, Karumanchi SA. Putting pressure on pre-eclampsia. Nat Med. 2008 Aug; 14(8):810-2. PMID: 18685593.
    Citations: 11     Fields:    Translation:HumansAnimals
  78. Gallagher DC, Parikh SM, Balonov K, Miller A, Gautam S, Talmor D, Sukhatme VP. Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock. 2008 Jun; 29(6):656-61. PMID: 18091573.
    Citations: 44     Fields:    Translation:HumansCells
  79. Cohen RA, Parikh SM. Images in clinical medicine. Calcinosis associated with renal failure. N Engl J Med. 2007 Dec 20; 357(25):2615. PMID: 18094381.
    Citations: 2     Fields:    Translation:Humans
  80. Giuliano JS, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS. Admission angiopoietin levels in children with septic shock. Shock. 2007 Dec; 28(6):650-654. PMID: 18092380.
    Citations: 54     Fields:    Translation:Humans
  81. Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007 Aug 17; 282(33):23910-8. PMID: 17562701.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  82. Gallagher DC, Bhatt RS, Parikh SM, Patel P, Seery V, McDermott DF, Atkins MB, Sukhatme VP. Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak. Clin Cancer Res. 2007 Apr 01; 13(7):2115-20. PMID: 17404094.
    Citations: 17     Fields:    Translation:HumansCells
  83. Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 2006 Mar; 3(3):e46. PMID: 16417407.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  84. Del Rio M, Imam A, DeLeon M, Gomez G, Mishra J, Ma Q, Parikh S, Devarajan P. The death domain of kidney ankyrin interacts with Fas and promotes Fas-mediated cell death in renal epithelia. J Am Soc Nephrol. 2004 Jan; 15(1):41-51. PMID: 14694156.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  85. Parikh SM, Diedrich A, Biaggioni I, Robertson D. The nature of the autonomic dysfunction in multiple system atrophy. J Neurol Sci. 2002 Aug 15; 200(1-2):1-10. PMID: 12127669.
    Citations: 13     Fields:    Translation:HumansCells
  86. Reddy VS, Parikh SM, Drinkwater DC, Lo A, Rauth TP, Moleski RM, Chang PA. Morbidity after procurement of radial arteries in diabetic patients and the elderly undergoing coronary revascularization. Ann Thorac Surg. 2002 Mar; 73(3):803-7; discussion 807-8. PMID: 11899184.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.