Harvard Catalyst Profiles

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Anthony Peter Adamis, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P30EY014104 (WIGGS, JANEY L) Apr 1, 2002 - Mar 31, 2014
    P30 Core Grant for Vision Research
    Role: Co-Principal Investigator
  2. R01EY012611 (ADAMIS, ANTHONY P) Apr 1, 1999 - Mar 31, 2002
    Role: Principal Investigator
  3. R01EY011627 (ADAMIS, ANTHONY P) Aug 1, 1997 - Jul 31, 2002
    Role: Principal Investigator
  4. K11EY000325 (ADAMIS, ANTHONY P) Aug 1, 1992 - Jul 31, 1997
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Adamis AP, Brittain CJ, Dandekar A, Hopkins JJ. Building on the success of anti-vascular endothelial growth factor therapy: a vision for the next decade. Eye (Lond). 2020 Jun 15. PMID: 32541890.
  2. Campochiaro PA, Marcus DM, Awh CC, Regillo C, Adamis AP, Bantseev V, Chiang Y, Ehrlich JS, Erickson S, Hanley WD, Horvath J, Maass KF, Singh N, Tang F, Barteselli G. The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial. Ophthalmology. 2019 08; 126(8):1141-1154. PMID: 30946888.
  3. Arcadu F, Benmansour F, Maunz A, Michon J, Haskova Z, McClintock D, Adamis AP, Willis JR, Prunotto M. Deep Learning Predicts OCT Measures of Diabetic Macular Thickening From Color Fundus Photographs. Invest Ophthalmol Vis Sci. 2019 03 01; 60(4):852-857. PMID: 30821810.
  4. Ferrara N, Adamis AP. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016 06; 15(6):385-403. PMID: 26775688.
    Citations: 68     Fields:    Translation:Humans
  5. Rubio RG, Adamis AP. Ocular Angiogenesis: Vascular Endothelial Growth Factor and Other Factors. Dev Ophthalmol. 2016; 55:28-37. PMID: 26502333.
    Citations: 3     Fields:    Translation:Humans
  6. Adamis AP, Ehrlich J, Fung A. Targeting the Effect of VEGF in Diabetic Macular Edema. N Engl J Med. 2015 07 30; 373(5):480-1. PMID: 26222568.
    Citations: 1     Fields:    Translation:Humans
  7. Nagai N, Lundh von Leithner P, Izumi-Nagai K, Hosking B, Chang B, Hurd R, Adamson P, Adamis AP, Foxton RH, Ng YS, Shima DT. Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction. Invest Ophthalmol Vis Sci. 2014 May 20; 55(6):3709-19. PMID: 24845632.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Brown DM, Nguyen QD, Marcus DM, Boyer DS, Patel S, Feiner L, Schlottmann PG, Rundle AC, Zhang J, Rubio RG, Adamis AP, Ehrlich JS, Hopkins JJ. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE. Ophthalmology. 2013 Oct; 120(10):2013-22. PMID: 23706949.
    Citations: 130     Fields:    Translation:HumansCTClinical Trials
  9. Brown DM, Campochiaro PA, Bhisitkul RB, Ho AC, Gray S, Saroj N, Adamis AP, Rubio RG, Murahashi WY. Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study. Ophthalmology. 2011 Aug; 118(8):1594-602. PMID: 21684606.
    Citations: 105     Fields:    Translation:HumansCTClinical Trials
  10. Karagianni N, Adamis AP. The case for complement and inflammation in AMD: open questions. Adv Exp Med Biol. 2010; 703:1-7. PMID: 20711703.
    Citations: 4     Fields:    Translation:Humans
  11. Zahn G, Volk K, Lewis GP, Vossmeyer D, Stragies R, Heier JS, Daniel PE, Adamis AP, Chapin EA, Fisher SK, Holz FG, Löffler KU, Knolle J. Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):1028-35. PMID: 19815730.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  12. Zahn G, Vossmeyer D, Stragies R, Wills M, Wong CG, Löffler KU, Adamis AP, Knolle J. Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization. Arch Ophthalmol. 2009 Oct; 127(10):1329-35. PMID: 19822850.
    Citations: 10     Fields:    Translation:Animals
  13. Adamis AP. The rationale for drug combinations in age-related macular degeneration. Retina. 2009 Jun; 29(6 Suppl):S42-4. PMID: 19553800.
    Citations: 3     Fields:    Translation:HumansAnimals
  14. Adamis AP, Miller JW. Judah Folkman. Semin Ophthalmol. 2009 May-Jun; 24(3):128-9. PMID: 19437346.
    Citations:    Fields:    Translation:Humans
  15. Wroblewski JJ, Wells JA, Adamis AP, Buggage RR, Cunningham ET, Goldbaum M, Guyer DR, Katz B, Altaweel MM. Pegaptanib sodium for macular edema secondary to central retinal vein occlusion. Arch Ophthalmol. 2009 Apr; 127(4):374-80. PMID: 19365011.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  16. Ellenberg D, Shi J, Jain S, Chang JH, Ripps H, Brady S, Melhem ER, Lakkis F, Adamis A, Chen DF, Ellis-Behnke R, Langer RS, Strittmatter SM, Azar DT. Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation. Br J Ophthalmol. 2009 Sep; 93(9):1134-40. PMID: 19286686.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Singerman LJ, Masonson H, Patel M, Adamis AP, Buggage R, Cunningham E, Goldbaum M, Katz B, Guyer D. Pegaptanib sodium for neovascular age-related macular degeneration: third-year safety results of the VEGF Inhibition Study in Ocular Neovascularisation (VISION) trial. Br J Ophthalmol. 2008 Dec; 92(12):1606-11. PMID: 18614570.
    Citations: 30     Fields:    Translation:Humans
  18. Adamis AP, Berman AJ. Immunological mechanisms in the pathogenesis of diabetic retinopathy. Semin Immunopathol. 2008 Apr; 30(2):65-84. PMID: 18340447.
    Citations: 108     Fields:    Translation:Humans
  19. Ju M, Mailhos C, Bradley J, Dowie T, Ganley M, Cook G, Calias P, Lange N, Adamis AP, Shima DT, Robinson GS. Simultaneous but not prior inhibition of VEGF165 enhances the efficacy of photodynamic therapy in multiple models of ocular neovascularization. Invest Ophthalmol Vis Sci. 2008 Feb; 49(2):662-70. PMID: 18235012.
    Citations: 8     Fields:    Translation:Animals
  20. Javitt JC, Zlateva GP, Earnshaw SR, Pleil AM, Graham CN, Brogan AJ, Shah SN, Adamis AP. Cost-effectiveness model for neovascular age-related macular degeneration: comparing early and late treatment with pegaptanib sodium based on visual acuity. Value Health. 2008 Jul-Aug; 11(4):563-74. PMID: 18179676.
    Citations: 8     Fields:    Translation:Humans
  21. Nishijima K, Ng YS, Zhong L, Bradley J, Schubert W, Jo N, Akita J, Samuelsson SJ, Robinson GS, Adamis AP, Shima DT. Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am J Pathol. 2007 Jul; 171(1):53-67. PMID: 17591953.
    Citations: 207     Fields:    Translation:HumansAnimals
  22. Apte RS, Modi M, Masonson H, Patel M, Whitfield L, Adamis AP. Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration. Ophthalmology. 2007 Sep; 114(9):1702-12. PMID: 17509689.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  23. Zhong L, Bradley J, Schubert W, Ahmed E, Adamis AP, Shima DT, Robinson GS, Ng YS. Erythropoietin promotes survival of retinal ganglion cells in DBA/2J glaucoma mice. Invest Ophthalmol Vis Sci. 2007 Mar; 48(3):1212-8. PMID: 17325165.
    Citations: 49     Fields:    Translation:AnimalsCells
  24. Kaji Y, Usui T, Ishida S, Yamashiro K, Moore TC, Moore J, Yamamoto Y, Yamamoto H, Adamis AP. Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. Invest Ophthalmol Vis Sci. 2007 Feb; 48(2):858-65. PMID: 17251488.
    Citations: 55     Fields:    Translation:Animals
  25. Starita C, Patel M, Katz B, Adamis AP. Vascular endothelial growth factor and the potential therapeutic use of pegaptanib (macugen) in diabetic retinopathy. Dev Ophthalmol. 2007; 39:122-148. PMID: 17245083.
    Citations: 21     Fields:    Translation:HumansAnimals
  26. Jo N, Ju M, Nishijima K, Robinson GS, Adamis AP, Shima DT, Mailhos C. Inhibitory effect of an antibody to cryptic collagen type IV epitopes on choroidal neovascularization. Mol Vis. 2006 Oct 26; 12:1243-9. PMID: 17110907.
    Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
  27. Ng EW, Adamis AP. Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseases. Ann N Y Acad Sci. 2006 Oct; 1082:151-71. PMID: 17145936.
    Citations: 36     Fields:    Translation:Humans
  28. Lu M, Adamis AP. Molecular biology of choroidal neovascularization. Ophthalmol Clin North Am. 2006 Sep; 19(3):323-34. PMID: 16935207.
    Citations: 22     Fields:    Translation:HumansAnimals
  29. Chakravarthy U, Adamis AP, Cunningham ET, Goldbaum M, Guyer DR, Katz B, Patel M. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology. 2006 Sep; 113(9):1508.e1-25. PMID: 16828500.
    Citations: 71     Fields:    Translation:Humans
  30. Jo N, Mailhos C, Ju M, Cheung E, Bradley J, Nishijima K, Robinson GS, Adamis AP, Shima DT. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol. 2006 Jun; 168(6):2036-53. PMID: 16723717.
    Citations: 72     Fields:    Translation:AnimalsCells
  31. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. PMID: 16735995.
    Citations: 16     Fields:    Translation:Humans
  32. D'Amico DJ, Masonson HN, Patel M, Adamis AP, Cunningham ET, Guyer DR, Katz B. Pegaptanib sodium for neovascular age-related macular degeneration: two-year safety results of the two prospective, multicenter, controlled clinical trials. Ophthalmology. 2006 Jun; 113(6):992-1001.e6. PMID: 16647134.
    Citations: 45     Fields:    Translation:Humans
  33. Ng EW, Shima DT, Calias P, Cunningham ET, Guyer DR, Adamis AP. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov. 2006 Feb; 5(2):123-32. PMID: 16518379.
    Citations: 242     Fields:    Translation:HumansAnimals
  34. Adamis AP, Altaweel M, Bressler NM, Cunningham ET, Davis MD, Goldbaum M, Gonzales C, Guyer DR, Barrett K, Patel M. Changes in retinal neovascularization after pegaptanib (Macugen) therapy in diabetic individuals. Ophthalmology. 2006 Jan; 113(1):23-8. PMID: 16343627.
    Citations: 50     Fields:    Translation:Humans
  35. Cunningham ET, Adamis AP, Altaweel M, Aiello LP, Bressler NM, D'Amico DJ, Goldbaum M, Guyer DR, Katz B, Patel M, Schwartz SD. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology. 2005 Oct; 112(10):1747-57. PMID: 16154196.
    Citations: 137     Fields:    Translation:HumansCTClinical Trials
  36. Ng EW, Adamis AP. Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration. Can J Ophthalmol. 2005 Jun; 40(3):352-68. PMID: 15947805.
    Citations: 62     Fields:    Translation:Humans
  37. Adamis AP, Shima DT. The role of vascular endothelial growth factor in ocular health and disease. Retina. 2005 Feb-Mar; 25(2):111-8. PMID: 15689799.
    Citations: 66     Fields:    Translation:Humans
  38. Gragoudas ES, Adamis AP, Cunningham ET, Feinsod M, Guyer DR. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med. 2004 Dec 30; 351(27):2805-16. PMID: 15625332.
    Citations: 462     Fields:    Translation:HumansCTClinical Trials
  39. Poulaki V, Joussen AM, Mitsiades N, Mitsiades CS, Iliaki EF, Adamis AP. Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy. Am J Pathol. 2004 Aug; 165(2):457-69. PMID: 15277220.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  40. Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004 Sep; 18(12):1450-2. PMID: 15231732.
    Citations: 336     Fields:    Translation:AnimalsCells
  41. Usui T, Ishida S, Yamashiro K, Kaji Y, Poulaki V, Moore J, Moore T, Amano S, Horikawa Y, Dartt D, Golding M, Shima DT, Adamis AP. VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):368-74. PMID: 14744874.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  42. Lu M, Adamis AP. Ocular delivery of angiostatic agents. Int Ophthalmol Clin. 2004; 44(3):41-51. PMID: 15211176.
    Citations: 1     Fields:    Translation:Humans
  43. Moore TC, Moore JE, Kaji Y, Frizzell N, Usui T, Poulaki V, Campbell IL, Stitt AW, Gardiner TA, Archer DB, Adamis AP. The role of advanced glycation end products in retinal microvascular leukostasis. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4457-64. PMID: 14507893.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  44. Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J, Miller JW, Gragoudas ES, Ng YS, D'Amore PA, Shima DT, Adamis AP. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med. 2003 Aug 04; 198(3):483-9. PMID: 12900522.
    Citations: 117     Fields:    Translation:AnimalsCells
  45. Ambati BK, Joussen AM, Kuziel WA, Adamis AP, Ambati J. Inhibition of corneal neovascularization by genetic ablation of CCR2. Cornea. 2003 Jul; 22(5):465-7. PMID: 12827053.
    Citations: 12     Fields:    Translation:Animals
  46. Yamashiro K, Tsujikawa A, Ishida S, Usui T, Kaji Y, Honda Y, Ogura Y, Adamis AP. Platelets accumulate in the diabetic retinal vasculature following endothelial death and suppress blood-retinal barrier breakdown. Am J Pathol. 2003 Jul; 163(1):253-9. PMID: 12819029.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  47. Sakurai E, Taguchi H, Anand A, Ambati BK, Gragoudas ES, Miller JW, Adamis AP, Ambati J. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2743-9. PMID: 12766082.
    Citations: 34     Fields:    Translation:AnimalsCells
  48. Ishida S, Yamashiro K, Usui T, Kaji Y, Ogura Y, Hida T, Honda Y, Oguchi Y, Adamis AP. Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. Nat Med. 2003 Jun; 9(6):781-8. PMID: 12730690.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  49. Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol. 2003 May-Jun; 48(3):257-93. PMID: 12745003.
    Citations: 245     Fields:    Translation:HumansAnimals
  50. Ishida S, Usui T, Yamashiro K, Kaji Y, Ahmed E, Carrasquillo KG, Amano S, Hida T, Oguchi Y, Adamis AP. VEGF164 is proinflammatory in the diabetic retina. Invest Ophthalmol Vis Sci. 2003 May; 44(5):2155-62. PMID: 12714656.
    Citations: 98     Fields:    Translation:Animals
  51. Greene AK, Wiener S, Puder M, Yoshida A, Shi B, Perez-Atayde AR, Efstathiou JA, Holmgren L, Adamis AP, Rupnick M, Folkman J, O'Reilly MS. Endothelial-directed hepatic regeneration after partial hepatectomy. Ann Surg. 2003 Apr; 237(4):530-5. PMID: 12677150.
    Citations: 29     Fields:    Translation:AnimalsCells
  52. Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37. PMID: 12606527.
    Citations: 35     Fields:    Translation:Animals
  53. Ambati BK, Anand A, Joussen AM, Kuziel WA, Adamis AP, Ambati J. Sustained inhibition of corneal neovascularization by genetic ablation of CCR5. Invest Ophthalmol Vis Sci. 2003 Feb; 44(2):590-3. PMID: 12556387.
    Citations: 20     Fields:    Translation:Animals
  54. Kaji Y, Amano S, Usui T, Oshika T, Yamashiro K, Ishida S, Suzuki K, Tanaka S, Adamis AP, Nagai R, Horiuchi S. Expression and function of receptors for advanced glycation end products in bovine corneal endothelial cells. Invest Ophthalmol Vis Sci. 2003 Feb; 44(2):521-8. PMID: 12556378.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  55. Carrasquillo KG, Ricker JA, Rigas IK, Miller JW, Gragoudas ES, Adamis AP. Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):290-9. PMID: 12506087.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  56. Joussen AM, Poulaki V, Mitsiades N, Stechschulte SU, Kirchhof B, Dartt DA, Fong GH, Rudge J, Wiegand SJ, Yancopoulos GD, Adamis AP. VEGF-dependent conjunctivalization of the corneal surface. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):117-23. PMID: 12506063.
    Citations: 18     Fields:    Translation:AnimalsCells
  57. Ciardella AP, Donsoff IM, Guyer DR, Adamis A, Yannuzzi LA. Antiangiogenesis agents. Ophthalmol Clin North Am. 2002 Dec; 15(4):453-8. PMID: 12515077.
    Citations: 2     Fields:    Translation:Humans
  58. Joussen AM, Poulaki V, Mitsiades N, Cai WY, Suzuma I, Pak J, Ju ST, Rook SL, Esser P, Mitsiades CS, Kirchhof B, Adamis AP, Aiello LP. Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes. FASEB J. 2003 Jan; 17(1):76-8. PMID: 12475915.
    Citations: 58     Fields:    Translation:AnimalsCells
  59. Moore JE, McMullen TC, Campbell IL, Rohan R, Kaji Y, Afshari NA, Usui T, Archer DB, Adamis AP. The inflammatory milieu associated with conjunctivalized cornea and its alteration with IL-1 RA gene therapy. Invest Ophthalmol Vis Sci. 2002 Sep; 43(9):2905-15. PMID: 12202509.
    Citations: 13     Fields:    Translation:AnimalsCells
  60. Ambati BK, Joussen AM, Ambati J, Moromizato Y, Guha C, Javaherian K, Gillies S, O'Reilly MS, Adamis AP. Angiostatin inhibits and regresses corneal neovascularization. Arch Ophthalmol. 2002 Aug; 120(8):1063-8. PMID: 12149060.
    Citations: 15     Fields:    Translation:Animals
  61. Moore JE, McMullen CB, Mahon G, Adamis AP. The corneal epithelial stem cell. DNA Cell Biol. 2002 May-Jun; 21(5-6):443-51. PMID: 12167247.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  62. Joussen AM, Poulaki V, Tsujikawa A, Qin W, Qaum T, Xu Q, Moromizato Y, Bursell SE, Wiegand SJ, Rudge J, Ioffe E, Yancopoulos GD, Adamis AP. Suppression of diabetic retinopathy with angiopoietin-1. Am J Pathol. 2002 May; 160(5):1683-93. PMID: 12000720.
    Citations: 55     Fields:    Translation:AnimalsCells
  63. Adamis AP. Is diabetic retinopathy an inflammatory disease? Br J Ophthalmol. 2002 Apr; 86(4):363-5. PMID: 11914197.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  64. Götte M, Joussen AM, Klein C, Andre P, Wagner DD, Hinkes MT, Kirchhof B, Adamis AP, Bernfield M. Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature. Invest Ophthalmol Vis Sci. 2002 Apr; 43(4):1135-41. PMID: 11923257.
    Citations: 23     Fields:    Translation:AnimalsCells
  65. Poulaki V, Qin W, Joussen AM, Hurlbut P, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J Clin Invest. 2002 Mar; 109(6):805-15. PMID: 11901189.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  66. Ambati J, Adamis AP. Transscleral drug delivery to the retina and choroid. Prog Retin Eye Res. 2002 Mar; 21(2):145-51. PMID: 12062532.
    Citations: 15     Fields:    Translation:HumansAnimals
  67. Husain D, Ambati B, Adamis AP, Miller JW. Mechanisms of age-related macular degeneration. Ophthalmol Clin North Am. 2002 Mar; 15(1):87-91. PMID: 12064086.
    Citations: 13     Fields:    Translation:Humans
  68. Lu M, Adamis AP. Vascular endothelial growth factor gene regulation and action in diabetic retinopathy. Ophthalmol Clin North Am. 2002 Mar; 15(1):69-79. PMID: 12064083.
    Citations: 12     Fields:    Translation:Humans
  69. Tolentino MJ, McLeod DS, Taomoto M, Otsuji T, Adamis AP, Lutty GA. Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate. Am J Ophthalmol. 2002 Mar; 133(3):373-85. PMID: 11860975.
    Citations: 55     Fields:    Translation:Animals
  70. Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michaud NA, Li W, Connolly E, O'Neill CA, Miller JW. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 2002 Mar; 120(3):338-46. PMID: 11879138.
    Citations: 112     Fields:    Translation:Animals
  71. Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol. 2002 Feb; 160(2):501-9. PMID: 11839570.
    Citations: 88     Fields:    Translation:AnimalsCells
  72. Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Döhmen S, Adamis AP. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J. 2002 Mar; 16(3):438-40. PMID: 11821258.
    Citations: 162     Fields:    Translation:AnimalsCells
  73. Joussen AM, Huang S, Poulaki V, Camphausen K, Beecken WD, Kirchhof B, Adamis AP. In vivo retinal gene expression in early diabetes. Invest Ophthalmol Vis Sci. 2001 Nov; 42(12):3047-57. PMID: 11687554.
    Citations: 25     Fields:    Translation:AnimalsCells
  74. Qaum T, Xu Q, Joussen AM, Clemens MW, Qin W, Miyamoto K, Hassessian H, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2408-13. PMID: 11527957.
    Citations: 127     Fields:    Translation:Animals
  75. Stechschulte SU, Joussen AM, von Recum HA, Poulaki V, Moromizato Y, Yuan J, D'Amato RJ, Kuo C, Adamis AP. Rapid ocular angiogenic control via naked DNA delivery to cornea. Invest Ophthalmol Vis Sci. 2001 Aug; 42(9):1975-9. PMID: 11481260.
    Citations: 26     Fields:    Translation:Animals
  76. Schwesinger C, Yee C, Rohan RM, Joussen AM, Fernandez A, Meyer TN, Poulaki V, Ma JJ, Redmond TM, Liu S, Adamis AP, D'Amato RJ. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol. 2001 Mar; 158(3):1161-72. PMID: 11238064.
    Citations: 52     Fields:    Translation:AnimalsCells
  77. Xu Q, Qaum T, Adamis AP. Sensitive blood-retinal barrier breakdown quantitation using Evans blue. Invest Ophthalmol Vis Sci. 2001 Mar; 42(3):789-94. PMID: 11222542.
    Citations: 85     Fields:    Translation:Animals
  78. Afshari NA, Mullally JE, Afshari MA, Steinert RF, Adamis AP, Azar DT, Talamo JH, Dohlman CH, Dryja TP. Survey of patients with granular, lattice, avellino, and Reis-Bücklers corneal dystrophies for mutations in the BIGH3 and gelsolin genes. Arch Ophthalmol. 2001 Jan; 119(1):16-22. PMID: 11146721.
    Citations: 17     Fields:    Translation:Humans
  79. Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP. Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol. 2001 Jan; 158(1):147-52. PMID: 11141487.
    Citations: 166     Fields:    Translation:AnimalsCells
  80. Moromizato Y, Stechschulte S, Miyamoto K, Murata T, Tsujikawa A, Joussen AM, Adamis AP. CD18 and ICAM-1-dependent corneal neovascularization and inflammation after limbal injury. Am J Pathol. 2000 Oct; 157(4):1277-81. PMID: 11021832.
    Citations: 8     Fields:    Translation:AnimalsCells
  81. Shiuey Y, Ambati BK, Adamis AP. A randomized, double-masked trial of topical ketorolac versus artificial tears for treatment of viral conjunctivitis. Ophthalmology. 2000 Aug; 107(8):1512-7. PMID: 10919900.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  82. Hofman P, Blaauwgeers HG, Tolentino MJ, Adamis AP, Nunes Cardozo BJ, Vrensen GF, Schlingemann RO. VEGF-A induced hyperpermeability of blood-retinal barrier endothelium in vivo is predominantly associated with pinocytotic vesicular transport and not with formation of fenestrations. Vascular endothelial growth factor-A. Curr Eye Res. 2000 Aug; 21(2):637-45. PMID: 11148600.
    Citations: 19     Fields:    Translation:AnimalsCells
  83. Miyamoto K, Khosrof S, Bursell SE, Moromizato Y, Aiello LP, Ogura Y, Adamis AP. Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). Am J Pathol. 2000 May; 156(5):1733-9. PMID: 10793084.
    Citations: 75     Fields:    Translation:Animals
  84. Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1153-8. PMID: 10752954.
    Citations: 82     Fields:    Translation:AnimalsCells
  85. Ambati J, Canakis CS, Miller JW, Gragoudas ES, Edwards A, Weissgold DJ, Kim I, Delori FC, Adamis AP. Diffusion of high molecular weight compounds through sclera. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1181-5. PMID: 10752958.
    Citations: 56     Fields:    Translation:Animals
  86. Ambati J, Gragoudas ES, Miller JW, You TT, Miyamoto K, Delori FC, Adamis AP. Transscleral delivery of bioactive protein to the choroid and retina. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1186-91. PMID: 10752959.
    Citations: 24     Fields:    Translation:Animals
  87. Tolentino MJ, Husain D, Theodosiadis P, Gragoudas ES, Connolly E, Kahn J, Cleland J, Adamis AP, Cuthbertson A, Miller JW. Angiography of fluoresceinated anti-vascular endothelial growth factor antibody and dextrans in experimental choroidal neovascularization. Arch Ophthalmol. 2000 Jan; 118(1):78-84. PMID: 10636419.
    Citations: 8     Fields:    Translation:Animals
  88. Alexandrakis G, Filatov V, Adamis AP. Denovo development of corneal guttae and Fuchs' dystrophy in corneal grafts. CLAO J. 2000 Jan; 26(1):44-6. PMID: 10656310.
    Citations: 2     Fields:    Translation:Humans
  89. Lu M, Amano S, Miyamoto K, Garland R, Keough K, Qin W, Adamis AP. Insulin-induced vascular endothelial growth factor expression in retina. Invest Ophthalmol Vis Sci. 1999 Dec; 40(13):3281-6. PMID: 10586954.
    Citations: 19     Fields:    Translation:AnimalsCells
  90. Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC, Aiello LP, Ogura Y, Adamis AP. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10836-41. PMID: 10485912.
    Citations: 203     Fields:    Translation:AnimalsCells
  91. Kim I, Ryan AM, Rohan R, Amano S, Agular S, Miller JW, Adamis AP. Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes. Invest Ophthalmol Vis Sci. 1999 Aug; 40(9):2115-21. PMID: 10440268.
    Citations: 39     Fields:    Translation:Animals
  92. Lu M, Perez VL, Ma N, Miyamoto K, Peng HB, Liao JK, Adamis AP. VEGF increases retinal vascular ICAM-1 expression in vivo. Invest Ophthalmol Vis Sci. 1999 Jul; 40(8):1808-12. PMID: 10393052.
    Citations: 59     Fields:    Translation:HumansAnimals
  93. Ghiso N, Rohan RM, Amano S, Garland R, Adamis AP. Suppression of hypoxia-associated vascular endothelial growth factor gene expression by nitric oxide via cGMP. Invest Ophthalmol Vis Sci. 1999 May; 40(6):1033-9. PMID: 10235536.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  94. Adamis AP, Aiello LP, D'Amato RA. Angiogenesis and ophthalmic disease. Angiogenesis. 1999; 3(1):9-14. PMID: 14517440.
    Citations: 26     Fields:    
  95. Lee P, Wang CC, Adamis AP. Ocular neovascularization: an epidemiologic review. Surv Ophthalmol. 1998 Nov-Dec; 43(3):245-69. PMID: 9862312.
    Citations: 77     Fields:    Translation:Humans
  96. Lu M, Kuroki M, Amano S, Tolentino M, Keough K, Kim I, Bucala R, Adamis AP. Advanced glycation end products increase retinal vascular endothelial growth factor expression. J Clin Invest. 1998 Mar 15; 101(6):1219-24. PMID: 9502762.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  97. Tripathi RC, Li J, Tripathi BJ, Chalam KV, Adamis AP. Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma. Ophthalmology. 1998 Feb; 105(2):232-7. PMID: 9479280.
    Citations: 45     Fields:    Translation:Humans
  98. Yoo SH, Adamis AP. Retinal manifestations of aging. Int Ophthalmol Clin. 1998; 38(1):95-101. PMID: 9532474.
    Citations:    Fields:    Translation:HumansAnimals
  99. An BB, Adamis AP. Chlamydial ocular diseases. Int Ophthalmol Clin. 1998; 38(1):221-30. PMID: 9532483.
    Citations: 1     Fields:    Translation:Humans
  100. Tolentino MJ, Adamis AP. Angiogenic factors in the development of diabetic iris neovascularization and retinopathy. Int Ophthalmol Clin. 1998; 38(1):77-94. PMID: 9532473.
    Citations: 2     Fields:    Translation:Humans
  101. Amano S, Rohan R, Kuroki M, Tolentino M, Adamis AP. Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization. Invest Ophthalmol Vis Sci. 1998 Jan; 39(1):18-22. PMID: 9430540.
    Citations: 66     Fields:    Translation:Animals
  102. Pournaras CJ, Miller JW, Gragoudas ES, Husain D, Munoz JL, Tolentino MJ, Kuroki M, Adamis AP. Systemic hyperoxia decreases vascular endothelial growth factor gene expression in ischemic primate retina. Arch Ophthalmol. 1997 Dec; 115(12):1553-8. PMID: 9400789.
    Citations: 7     Fields:    Translation:Animals
  103. Punglia RS, Lu M, Hsu J, Kuroki M, Tolentino MJ, Keough K, Levy AP, Levy NS, Goldberg MA, D'Amato RJ, Adamis AP. Regulation of vascular endothelial growth factor expression by insulin-like growth factor I. Diabetes. 1997 Oct; 46(10):1619-26. PMID: 9313759.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  104. Miller JW, Adamis AP, Aiello LP. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev. 1997 Mar; 13(1):37-50. PMID: 9134347.
    Citations: 71     Fields:    Translation:HumansAnimals
  105. Baum TD, Adamis AP, Jakobiec FA. Primary acquired melanosis of the conjunctiva. Int Ophthalmol Clin. 1997; 37(4):61-72. PMID: 9429932.
    Citations:    Fields:    Translation:HumansAnimals
  106. Nicaeus TE, Tolentino MJ, Adamis AP, Rubin PA. Sucralfate and basic fibroblast growth factor promote endothelial cell proliferation around porous alloplastic implants in vitro. Ophthalmic Plast Reconstr Surg. 1996 Dec; 12(4):235-9. PMID: 8944383.
    Citations: 4     Translation:AnimalsCells
  107. Tolentino MJ, Miller JW, Gragoudas ES, Jakobiec FA, Flynn E, Chatzistefanou K, Ferrara N, Adamis AP. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology. 1996 Nov; 103(11):1820-8. PMID: 8942877.
    Citations: 95     Fields:    Translation:Animals
  108. Kuroki M, Voest EE, Amano S, Beerepoot LV, Takashima S, Tolentino M, Kim RY, Rohan RM, Colby KA, Yeo KT, Adamis AP. Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. J Clin Invest. 1996 Oct 01; 98(7):1667-75. PMID: 8833917.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  109. Loughman MS, Chatzistefanou K, Gonzalez EM, Flynn E, Adamis AP, Shing Y, D'Amato RJ, Folkman J. Experimental corneal neovascularisation using sucralfate and basic fibroblast growth factor. Aust N Z J Ophthalmol. 1996 Aug; 24(3):289-95. PMID: 8913136.
    Citations: 5     Fields:    Translation:Animals
  110. Tolentino MJ, Miller JW, Gragoudas ES, Chatzistefanou K, Ferrara N, Adamis AP. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch Ophthalmol. 1996 Aug; 114(8):964-70. PMID: 8694732.
    Citations: 57     Fields:    Translation:Animals
  111. Shima DT, Gougos A, Miller JW, Tolentino M, Robinson G, Adamis AP, D'Amore PA. Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis. Invest Ophthalmol Vis Sci. 1996 Jun; 37(7):1334-40. PMID: 8641836.
    Citations: 22     Fields:    Translation:AnimalsCells
  112. Huang SH, Adamis AP, Wiederschain DG, Shima DT, Shing Y, Moses MA. Matrix metalloproteinases and their inhibitors in aqueous humor. Exp Eye Res. 1996 May; 62(5):481-90. PMID: 8759516.
    Citations: 4     Fields:    Translation:Animals
  113. Shima DT, Kuroki M, Deutsch U, Ng YS, Adamis AP, D'Amore PA. The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J Biol Chem. 1996 Feb 16; 271(7):3877-83. PMID: 8632007.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  114. Adamis AP, Shima DT, Tolentino MJ, Gragoudas ES, Ferrara N, Folkman J, D'Amore PA, Miller JW. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol. 1996 Jan; 114(1):66-71. PMID: 8540853.
    Citations: 92     Fields:    Translation:Animals
  115. Durand M, Adamis A, Baker AS. Infections of the eyelid, lacrimal system, conjunctiva, and cornea. Curr Clin Top Infect Dis. 1996; 16:125-50. PMID: 8714251.
    Citations:    Fields:    Translation:Humans
  116. D'Amato RJ, Adamis AP. Angiogenesis inhibition in age-related macular degeneration. Ophthalmology. 1995 Sep; 102(9):1261-2. PMID: 9097761.
    Citations: 7     Fields:    Translation:HumansAnimals
  117. Adamis AP, D'Amato RJ. Shedding light on diabetic retinopathy. Ophthalmology. 1995 Aug; 102(8):1127-8. PMID: 9097736.
    Citations: 2     Fields:    Translation:HumansAnimals
  118. Shima DT, Adamis AP, Ferrara N, Yeo KT, Yeo TK, Allende R, Folkman J, D'Amore PA. Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med. 1995 Jan; 1(2):182-93. PMID: 8529097.
    Citations: 61     Fields:    Translation:HumansCells
  119. Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, Yeo TK, Yeo KT. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994 Oct 15; 118(4):445-50. PMID: 7943121.
    Citations: 263     Fields:    Translation:Humans
  120. Miller JW, Adamis AP, Shima DT, D'Amore PA, Moulton RS, O'Reilly MS, Folkman J, Dvorak HF, Brown LF, Berse B, et al. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol. 1994 Sep; 145(3):574-84. PMID: 7521577.
    Citations: 148     Fields:    Translation:Animals
  121. Lucarelli MJ, Adamis AP. Avellino corneal dystrophy. Arch Ophthalmol. 1994 Mar; 112(3):418-9. PMID: 8129670.
    Citations: 3     Fields:    Translation:Humans
  122. Navon SE, Adamis AP. Safety during the transition to phacoemulsification: a survey. Int Ophthalmol Clin. 1994; 34(3):51-65. PMID: 7960528.
    Citations: 1     Fields:    Translation:Humans
  123. Adamis AP, Filatov V, Tripathi BJ, Tripathi RC. Fuchs' endothelial dystrophy of the cornea. Surv Ophthalmol. 1993 Sep-Oct; 38(2):149-68. PMID: 8235998.
    Citations: 48     Fields:    Translation:Humans
  124. Adamis AP, Shima DT, Yeo KT, Yeo TK, Brown LF, Berse B, D'Amore PA, Folkman J. Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem Biophys Res Commun. 1993 Jun 15; 193(2):631-8. PMID: 8512562.
    Citations: 74     Fields:    Translation:HumansCells
  125. Adamis AP, Schein OD, Kenyon KR. Anterior corneal disease of epidermolysis bullosa simplex. Arch Ophthalmol. 1993 Apr; 111(4):499-502. PMID: 8470983.
    Citations: 1     Fields:    Translation:Humans
  126. Kowal VO, Adamis AP, Albert DM. Conjunctival concretions. Am J Ophthalmol. 1992 Nov 15; 114(5):640-1. PMID: 1443034.
    Citations:    Fields:    Translation:Humans
  127. Guyer DR, Adamis AP, Gragoudas ES, Folkman J, Slakter JS, Yannuzzi LA. Systemic antiangiogenic therapy for choroidal neovascularization. What is the role of interferon alfa? Arch Ophthalmol. 1992 Oct; 110(10):1383-4. PMID: 1384461.
    Citations: 1     Fields:    Translation:Humans
  128. Bilyk JR, Adamis AP, Mulliken JB. Treatment options for periorbital hemangioma of infancy. Int Ophthalmol Clin. 1992; 32(3):95-109. PMID: 1639604.
    Citations:    Fields:    Translation:Humans
  129. Adamis AP, Meklir B, Joyce NC. In situ injury-induced release of basic-fibroblast growth factor from corneal epithelial cells. Am J Pathol. 1991 Nov; 139(5):961-7. PMID: 1951634.
    Citations: 12     Fields:    Translation:AnimalsCells
  130. Adamis AP, Molnar ML, Tripathi BJ, Emmerson MS, Stefansson K, Tripathi RC. Neuronal-specific enolase in human corneal endothelium and posterior keratocytes. Exp Eye Res. 1985 Nov; 41(5):665-8. PMID: 4092758.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.