Harvard Catalyst Profiles

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Cynthia Ann Lemere, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG060057 (LEMERE, CYNTHIA A) Sep 1, 2018 - May 31, 2023
    NIH/NIA
    Novel Inducible Complement C3 Conditional KO Mouse Models to Investigate Neurodegeneration in AD
    Role: Principal Investigator
  2. R01AG058657 (LEMERE, CYNTHIA A) Mar 15, 2018 - Dec 31, 2022
    NIH/NIA
    AD Immunotherapy with a Novel CDC-Mutant Anti-Pyroglutamate-3 Abeta Antibody to Avoid Vascular Side Effects
    Role: Principal Investigator
  3. R21AG044713 (LEMERE, CYNTHIA A) Sep 30, 2013 - Jul 31, 2015
    NIH/NIA
    Generation of a Complement C3 Conditional Knockout Mouse
    Role: Principal Investigator
  4. R01AG040092 (LEMERE, CYNTHIA A) Sep 1, 2012 - Jul 31, 2016
    NIH/NIA
    Pyroglutamate Amyloid-beta as an Immunotherapeutic Target for Alzheimer's Disease
    Role: Principal Investigator
  5. R01AG020159 (LEMERE, CYNTHIA A) Sep 30, 2001 - Oct 31, 2012
    NIH/NIA
    Mucosal Abeta Vaccination: Modulating the Immune Response
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil MM, Lemere C, Rosi S. Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int J Mol Sci. 2018 Nov 26; 19(12). PMID: 30486287.
    Citations:    Fields:    
  2. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2019 Jan; 9(6):279-286. PMID: 30800043.
    Citations:    
  3. Schilling S, Rahfeld JU, Lues I, Lemere CA. Passive Aß Immunotherapy: Current Achievements and Future Perspectives. Molecules. 2018 May 03; 23(5). PMID: 29751505.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. Deposition of phosphorylated amyloid-ß in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. PMID: 29740941.
    Citations:    Fields:    Translation:AnimalsCells
  5. Lardenoije R, van den Hove DLA, Havermans M, van Casteren A, Le KX, Palmour R, Lemere CA, Rutten BPF. Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease. Mol Cell Neurosci. 2018 01; 86:1-15. PMID: 29113959.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 09 19; 47(3):566-581.e9. PMID: 28930663.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  7. Shi Q, Chowdhury S, Ma R, Le KX, Hong S, Caldarone BJ, Stevens B, Lemere CA. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566429.
    Citations: 15     Fields:    Translation:AnimalsCells
  8. Lee HK, Kwon B, Lemere CA, de la Monte S, Itamura K, Ha AY, Querfurth HW. mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-ß Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons. J Alzheimers Dis. 2017; 56(3):1015-1036. PMID: 28035937.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Larrick JW, Alfenito MR, Scott JK, Parren PW, Burton DR, Bradbury AR, Lemere CA, Messer A, Huston JS, Carter PJ, Veldman T, Chester KA, Schuurman J, Adams GP, Reichert JM. Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11-15, 2016, San Diego, CA. MAbs. 2016 Nov/Dec; 8(8):1425-1434. PMID: 27557809.
    Citations:    Fields:    Translation:HumansAnimals
  10. Cynis H, Frost JL, Crehan H, Lemere CA. Immunotherapy targeting pyroglutamate-3 Aß: prospects and challenges. Mol Neurodegener. 2016 06 30; 11(1):48. PMID: 27363697.
    Citations: 7     Fields:    Translation:HumansAnimals
  11. Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016 May 06; 352(6286):712-716. PMID: 27033548.
    Citations: 213     Fields:    Translation:AnimalsCells
  12. Head E, Lott IT, Wilcock DM, Lemere CA. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Curr Alzheimer Res. 2016; 13(1):18-29. PMID: 26651341.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  13. Liu B, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Lemere CA. In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice. J Neurosci. 2015 Nov 25; 35(47):15716-30. PMID: 26609163.
    Citations: 15     Fields:    Translation:HumansAnimals
  14. Shi Q, Colodner KJ, Matousek SB, Merry K, Hong S, Kenison JE, Frost JL, Le KX, Li S, Dodart JC, Caldarone BJ, Stevens B, Lemere CA. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015 Sep 23; 35(38):13029-42. PMID: 26400934.
    Citations: 43     Fields:    Translation:AnimalsCells
  15. Frost JL, Liu B, Rahfeld JU, Kleinschmidt M, O'Nuallain B, Le KX, Lues I, Caldarone BJ, Schilling S, Demuth HU, Lemere CA. An anti-pyroglutamate-3 Aß vaccine reduces plaques and improves cognition in APPswe/PS1?E9 mice. Neurobiol Aging. 2015 Dec; 36(12):3187-3199. PMID: 26453001.
    Citations: 11     Fields:    Translation:Animals
  16. Mably AJ, Liu W, Mc Donald JM, Dodart JC, Bard F, Lemere CA, O'Nuallain B, Walsh DM. Anti-Aß antibodies incapable of reducing cerebral Aß oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiol Dis. 2015 Oct; 82:372-384. PMID: 26215784.
    Citations: 7     Fields:    Translation:HumansAnimals
  17. Janota C, Lemere CA, Brito MA. Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer's Disease. Mol Neurobiol. 2016 08; 53(6):3793-3811. PMID: 26143259.
    Citations: 6     Fields:    Translation:HumansAnimals
  18. Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch HW, Mastroeni D, Coleman P, Lemere CA, Hof PR, van den Hove DL, Rutten BP. The epigenetics of aging and neurodegeneration. Prog Neurobiol. 2015 Aug; 131:21-64. PMID: 26072273.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  19. Janota CS, Brites D, Lemere CA, Brito MA. Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice. Brain Res. 2015 Sep 16; 1620:153-68. PMID: 25966615.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  20. Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM. Tau immunization: a cautionary tale? Neurobiol Aging. 2015 Mar; 36(3):1316-32. PMID: 25619661.
    Citations: 11     Fields:    Translation:Animals
  21. Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9. PMID: 25510383.
    Citations: 38     Fields:    Translation:HumansAnimals
  22. An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH. Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo. Mol Brain. 2013 Nov 13; 6:47. PMID: 24284042.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  23. Lemere CA. Immunotherapy for Alzheimer's disease: hoops and hurdles. Mol Neurodegener. 2013 Oct 22; 8:36. PMID: 24148220.
    Citations: 48     Fields:    Translation:HumansAnimals
  24. Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. PMID: 23747948.
    Citations: 25     Fields:    Translation:HumansAnimals
  25. Liu B, Frost JL, Sun J, Fu H, Grimes S, Blackburn P, Lemere CA. MER5101, a novel Aß1-15:DT conjugate vaccine, generates a robust anti-Aß antibody response and attenuates Aß pathology and cognitive deficits in APPswe/PS1?E9 transgenic mice. J Neurosci. 2013 Apr 17; 33(16):7027-37. PMID: 23595760.
    Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  26. Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet. 2013 Aug 01; 22(15):3077-92. PMID: 23585551.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  27. Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. Galactic cosmic radiation leads to cognitive impairment and increased aß plaque accumulation in a mouse model of Alzheimer's disease. PLoS One. 2012; 7(12):e53275. PMID: 23300905.
    Citations: 29     Fields:    Translation:Animals
  28. Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aß by microglia. Glia. 2012 May; 60(6):993-1003. PMID: 22438044.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  29. Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR, Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, Evans DA, Bennett DA, De Jager PL. A coding variant in CR1 interacts with APOE-e4 to influence cognitive decline. Hum Mol Genet. 2012 May 15; 21(10):2377-88. PMID: 22343410.
    Citations: 35     Fields:    Translation:Humans
  30. Frost JL, Liu B, Kleinschmidt M, Schilling S, Demuth HU, Lemere CA. Passive immunization against pyroglutamate-3 amyloid-ß reduces plaque burden in Alzheimer-like transgenic mice: a pilot study. Neurodegener Dis. 2012; 10(1-4):265-70. PMID: 22343072.
    Citations: 21     Fields:    Translation:HumansAnimals
  31. Lee S, Lemere CA, Frost JL, Shea TB. Dietary supplementation with S-adenosyl methionine delayed amyloid-ß and tau pathology in 3xTg-AD mice. J Alzheimers Dis. 2012; 28(2):423-31. PMID: 22045486.
    Citations: 11     Fields:    Translation:HumansAnimals
  32. Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther. 2011 Jan 06; 3(1):1. PMID: 21211070.
    Citations: 93     Fields:    
  33. Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J Neurosci. 2010 Jun 16; 30(24):8180-9. PMID: 20554868.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  34. Fu HJ, Liu B, Frost JL, Lemere CA. Amyloid-beta immunotherapy for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010 Apr; 9(2):197-206. PMID: 20205640.
    Citations: 21     Fields:    Translation:HumansAnimalsPHPublic Health
  35. Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol. 2010 Feb; 6(2):108-19. PMID: 20140000.
    Citations: 119     Fields:    Translation:HumansAnimals
  36. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X. L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol. 2009 Oct 25; 621(1-3):38-45. PMID: 19737553.
    Citations: 11     Fields:    Translation:AnimalsCells
  37. Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov; 36(2):293-302. PMID: 19660551.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  38. Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12145-50. PMID: 19581601.
    Citations: 47     Fields:    Translation:AnimalsCellsPHPublic Health
  39. Kadokura A, Yamazaki T, Kakuda S, Makioka K, Lemere CA, Fujita Y, Takatama M, Okamoto K. Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration. Neurosci Lett. 2009 Sep 29; 463(1):87-92. PMID: 19539703.
    Citations: 12     Fields:    Translation:HumansCells
  40. Kadokura A, Yamazaki T, Lemere CA, Takatama M, Okamoto K. Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathology. Neuropathology. 2009 Oct; 29(5):566-73. PMID: 19422539.
    Citations: 26     Fields:    Translation:HumansCells
  41. Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Mol Neurodegener. 2009 Feb 25; 4:12. PMID: 19243613.
    Citations: 15     Fields:    
  42. Lemere CA. Developing novel immunogens for a safe and effective Alzheimer's disease vaccine. Prog Brain Res. 2009; 175:83-93. PMID: 19660650.
    Citations: 31     Fields:    Translation:HumansAnimals
  43. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42. PMID: 18568035.
    Citations: 1123     Fields:    Translation:HumansAnimalsCells
  44. Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18; 28(25):6333-41. PMID: 18562603.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  45. Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci. 2008 Apr 16; 28(16):4231-7. PMID: 18417702.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
  46. Lemere CA, Oh J, Stanish HA, Peng Y, Pepivani I, Fagan AM, Yamaguchi H, Westmoreland SV, Mansfield KG. Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease? Rejuvenation Res. 2008 Apr; 11(2):321-32. PMID: 18341428.
    Citations: 11     Fields:    Translation:HumansAnimals
  47. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X. l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett. 2008 Mar 28; 434(2):224-9. PMID: 18328624.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  48. Kondo Y, Lemere CA, Seabrook TJ. Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. J Neuroinflammation. 2007 Dec 20; 4:31. PMID: 18093340.
    Citations: 14     Fields:    Translation:AnimalsCells
  49. Peng Y, Lee DY, Jiang L, Ma Z, Schachter SC, Lemere CA. Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. Neuroscience. 2007 Dec 05; 150(2):386-95. PMID: 17945434.
    Citations: 12     Fields:    Translation:HumansCells
  50. Lemere CA, Maier M, Peng Y, Jiang L, Seabrook TJ. Novel Abeta immunogens: is shorter better? Curr Alzheimer Res. 2007 Sep; 4(4):427-36. PMID: 17908047.
    Citations: 17     Fields:    Translation:HumansAnimals
  51. He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R, Shen Y. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol. 2007 Aug 27; 178(5):829-41. PMID: 17724122.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  52. Lemere CA. A beneficial role for IL-1 beta in Alzheimer disease? J Clin Invest. 2007 Jun; 117(6):1483-5. PMID: 17549252.
    Citations: 3     Fields:    Translation:HumansAnimals
  53. Peng Y, Jiang L, Lee DY, Schachter SC, Ma Z, Lemere CA. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells. J Neurosci Res. 2006 Sep; 84(4):903-11. PMID: 16862548.
    Citations: 9     Fields:    Translation:HumansCells
  54. Seabrook TJ, Jiang L, Thomas K, Lemere CA. Boosting with intranasal dendrimeric Abeta1-15 but not Abeta1-15 peptide leads to an effective immune response following a single injection of Abeta1-40/42 in APP-tg mice. J Neuroinflammation. 2006 Jun 05; 3:14. PMID: 16753065.
    Citations: 9     Fields:    
  55. Liu K, Solano I, Mann D, Lemere C, Mercken M, Trojanowski JQ, Lee VM. Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease. Acta Neuropathol. 2006 Aug; 112(2):163-74. PMID: 16865398.
    Citations: 24     Fields:    Translation:Humans
  56. Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiol Aging. 2007 Jun; 28(6):813-23. PMID: 16725229.
    Citations: 25     Fields:    Translation:HumansAnimals
  57. Maier M, Seabrook TJ, Lazo ND, Jiang L, Das P, Janus C, Lemere CA. Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. J Neurosci. 2006 May 03; 26(18):4717-28. PMID: 16672644.
    Citations: 59     Fields:    Translation:AnimalsCells
  58. Seabrook TJ, Jiang L, Maier M, Lemere CA. Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia. 2006 May; 53(7):776-82. PMID: 16534778.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  59. Lemere CA, Maier M, Jiang L, Peng Y, Seabrook TJ. Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans. Rejuvenation Res. 2006; 9(1):77-84. PMID: 16608400.
    Citations: 21     Fields:    Translation:HumansAnimalsPHPublic Health
  60. Maier M, Seabrook TJ, Lemere CA. Modulation of the humoral and cellular immune response in Abeta immunotherapy by the adjuvants monophosphoryl lipid A (MPL), cholera toxin B subunit (CTB) and E. coli enterotoxin LT(R192G). Vaccine. 2005 Oct 25; 23(44):5149-59. PMID: 16054274.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  61. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May; 11(5):556-61. PMID: 15834427.
    Citations: 159     Fields:    Translation:AnimalsCellsPHPublic Health
  62. Maier M, Seabrook TJ, Lemere CA. Developing novel immunogens for an effective, safe Alzheimer's disease vaccine. Neurodegener Dis. 2005; 2(5):267-72. PMID: 16909008.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  63. Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA. Species-specific immune response to immunization with human versus rodent A beta peptide. Neurobiol Aging. 2004 Oct; 25(9):1141-51. PMID: 15312960.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  64. Seabrook TJ, Iglesias M, Bloom JK, Spooner ET, Lemere CA. Differences in the immune response to long term Abeta vaccination in C57BL/6 and B6D2F1 mice. Vaccine. 2004 Sep 28; 22(29-30):4075-83. PMID: 15364459.
    Citations: 10     Fields:    Translation:AnimalsPHPublic Health
  65. Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem. 2004 Nov 05; 279(45):46907-14. PMID: 15345711.
    Citations: 48     Fields:    Translation:AnimalsCells
  66. Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin FR. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol. 2004 Jul; 165(1):283-97. PMID: 15215183.
    Citations: 67     Fields:    Translation:HumansAnimals
  67. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K. A seed for Alzheimer amyloid in the brain. J Neurosci. 2004 May 19; 24(20):4894-902. PMID: 15152051.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  68. Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET. Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mech Ageing Dev. 2004 Feb; 125(2):149-51. PMID: 15037022.
    Citations: 8     Fields:    Translation:Animals
  69. Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET. Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Dis Assoc Disord. 2004 Jan-Mar; 18(1):44-6. PMID: 15195463.
    Citations: 9     Fields:    Translation:AnimalsPHPublic Health
  70. Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH. APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol. 2003 Oct 13; 163(1):83-95. PMID: 14557249.
    Citations: 119     Fields:    Translation:HumansCells
  71. Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiol Dis. 2003 Oct; 14(1):10-8. PMID: 13678662.
    Citations: 43     Fields:    Translation:AnimalsPHPublic Health
  72. Lemere CA, Spooner ET, Leverone JF, Mori C, Iglesias M, Bloom JK, Seabrook TJ. Amyloid-beta immunization in Alzheimer's disease transgenic mouse models and wildtype mice. Neurochem Res. 2003 Jul; 28(7):1017-27. PMID: 12737526.
    Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
  73. Leverone JF, Spooner ET, Lehman HK, Clements JD, Lemere CA. Abeta1-15 is less immunogenic than Abeta1-40/42 for intranasal immunization of wild-type mice but may be effective for "boosting". Vaccine. 2003 May 16; 21(17-18):2197-206. PMID: 12706711.
    Citations: 14     Fields:    Translation:HumansAnimals
  74. Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid. 2003 Mar; 10(1):51-61. PMID: 12762144.
    Citations:    Fields:    Translation:HumansAnimals
  75. Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci. 2003 Jan 01; 23(1):29-33. PMID: 12514198.
    Citations: 79     Fields:    Translation:Animals
  76. Spooner ET, Desai RV, Mori C, Leverone JF, Lemere CA. The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol. Vaccine. 2002 Dec 13; 21(3-4):290-7. PMID: 12450704.
    Citations: 14     Fields:    Translation:AnimalsPHPublic Health
  77. Lemere CA, Spooner ET, Leverone JF, Mori C, Clements JD. Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants. Neurobiol Aging. 2002 Nov-Dec; 23(6):991-1000. PMID: 12470794.
    Citations: 23     Fields:    Translation:AnimalsCells
  78. Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid. 2002 Jun; 9(2):88-102. PMID: 12440481.
    Citations: 67     Fields:    Translation:HumansCells
  79. Lemere CA, Maron R, Selkoe DJ, Weiner HL. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol. 2001 Nov; 20(11):705-11. PMID: 11788048.
    Citations: 28     Fields:    Translation:Animals
  80. Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2001 Apr; 158(4):1345-54. PMID: 11290552.
    Citations: 65     Fields:    Translation:AnimalsCells
  81. Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol. 2000 Oct; 48(4):567-79. PMID: 11026440.
    Citations: 69     Fields:    Translation:HumansAnimals
  82. Kokubo H, Lemere CA, Yamaguchi H. Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology. Neurosci Lett. 2000 Aug 25; 290(2):93-6. PMID: 10936685.
    Citations: 10     Fields:    Translation:HumansCells
  83. Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. Am J Pathol. 2000 Feb; 156(2):489-99. PMID: 10666378.
    Citations: 36     Fields:    Translation:Humans
  84. Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann N Y Acad Sci. 2000; 920:328-31. PMID: 11193172.
    Citations: 31     Fields:    Translation:HumansAnimals
  85. Zhen W, Han H, Anguiano M, Lemere CA, Cho CG, Lansbury PT. Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain. J Med Chem. 1999 Jul 29; 42(15):2805-15. PMID: 10425090.
    Citations: 8     Fields:    Translation:Humans
  86. Lemere CA, Grenfell TJ, Selkoe DJ. The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome. Am J Pathol. 1999 Jul; 155(1):29-37. PMID: 10393833.
    Citations: 4     Fields:    Translation:HumansAnimals
  87. Fulton AB, Reynaud X, Hansen RM, Lemere CA, Parker C, Williams TP. Rod photoreceptors in infant rats with a history of oxygen exposure. Invest Ophthalmol Vis Sci. 1999 Jan; 40(1):168-74. PMID: 9888440.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  88. Lopera F, Ardilla A, Martínez A, Madrigal L, Arango-Viana JC, Lemere CA, Arango-Lasprilla JC, Hincapíe L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate AM, Ruiz-Linares A, Rosselli M, Kosik KS. Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. JAMA. 1997 Mar 12; 277(10):793-9. PMID: 9052708.
    Citations: 69     Fields:    Translation:Humans
  89. Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. J Biol Chem. 1996 Dec 27; 271(52):33623-31. PMID: 8969231.
    Citations: 26     Fields:    Translation:Humans
  90. Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango JC. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med. 1996 Oct; 2(10):1146-50. PMID: 8837617.
    Citations: 77     Fields:    Translation:HumansCells
  91. Yamaguchi H, Ishiguro K, Uchida T, Takashima A, Lemere CA, Imahori K. Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. Acta Neuropathol. 1996 Sep; 92(3):232-41. PMID: 8870824.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  92. Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol Dis. 1996 Feb; 3(1):51-63. PMID: 9173912.
    Citations: 48     Fields:    Translation:HumansCells
  93. Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis. 1996 Feb; 3(1):16-32. PMID: 9173910.
    Citations: 122     Fields:    Translation:HumansCells
  94. Schmidt JT, Lemere CA. Rapid activity-dependent sprouting of optic fibers into a local area denervated by application of beta-bungarotoxin in goldfish tectum. J Neurobiol. 1996 Jan; 29(1):75-90. PMID: 8748373.
    Citations:    Fields:    Translation:Animals
  95. Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med. 1995 Dec; 1(12):1291-6. PMID: 7489411.
    Citations: 122     Fields:    Translation:HumansCells
  96. Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. Biochem J. 1995 Oct 01; 311 ( Pt 1):299-305. PMID: 7575468.
    Citations: 12     Fields:    Translation:HumansCells
  97. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am J Pathol. 1995 Apr; 146(4):848-60. PMID: 7717452.
    Citations: 20     Fields:    Translation:Humans
  98. Shi GP, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15; 269(15):11530-6. PMID: 8157683.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  99. Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol. 1992 Jul; 141(1):249-59. PMID: 1632466.
    Citations: 30     Fields:    Translation:HumansCells
  100. Hansen LA, Natelson BH, Lemere C, Niemann W, De Teresa R, Regan TJ, Masliah E, Terry RD. Alcohol-induced brain changes in dogs. Arch Neurol. 1991 Sep; 48(9):939-42. PMID: 1953418.
    Citations: 4     Fields:    Translation:Animals
  101. Wiley CA, Masliah E, Morey M, Lemere C, DeTeresa R, Grafe M, Hansen L, Terry R. Neocortical damage during HIV infection. Ann Neurol. 1991 Jun; 29(6):651-7. PMID: 1909852.
    Citations: 98     Fields:    Translation:HumansCells
  102. Murphey RK, Lemere CA. Competition controls the growth of an identified axonal arborization. Science. 1984 Jun 22; 224(4655):1352-5. PMID: 6729457.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.