Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Cynthia Ann Lemere, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG060057 (LEMERE, CYNTHIA A) Sep 1, 2018 - May 31, 2023
    Novel Inducible Complement C3 Conditional KO Mouse Models to Investigate Neurodegeneration in AD
    Role: Principal Investigator
  2. RF1AG060057 (LEMERE, CYNTHIA A) Sep 1, 2018 - Mar 31, 2023
    Novel Inducible Complement C3 Conditional KO Mouse Models to Investigate Neurodegeneration in AD
    Role: Principal Investigator
  3. RF1AG058657 (LEMERE, CYNTHIA A) Mar 15, 2018 - Feb 28, 2023
    AD Immunotherapy with a Novel CDC-Mutant Anti-Pyroglutamate-3 Abeta Antibody to Avoid Vascular Side Effects
    Role: Principal Investigator
  4. R01AG058657 (LEMERE, CYNTHIA A) Mar 15, 2018 - Dec 31, 2022
    AD Immunotherapy with a Novel CDC-Mutant Anti-Pyroglutamate-3 Abeta Antibody to Avoid Vascular Side Effects
    Role: Principal Investigator
  5. R21AG044713 (LEMERE, CYNTHIA A) Sep 30, 2013 - Jul 31, 2016
    Generation of a Complement C3 Conditional Knockout Mouse
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bathini P, Sun T, Schenk M, Schilling S, McDannold NJ, Lemere CA. Acute Effects of Focused Ultrasound-Induced Blood-Brain Barrier Opening on Anti-Pyroglu3 Abeta Antibody Delivery and Immune Responses. Biomolecules. 2022 07 06; 12(7). PMID: 35883506; PMCID: PMC9313174.
    Citations:    Fields:    Translation:Animals
  2. Bairamian D, Sha S, Rolhion N, Sokol H, Dorothée G, Lemere CA, Krantic S. Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease. Mol Neurodegener. 2022 03 05; 17(1):19. PMID: 35248147; PMCID: PMC8898063.
    Citations: 3     Fields:    Translation:Humans
  3. Schroeder MK, Liu B, Hinshaw RG, Park MA, Wang S, Dubey S, Liu GG, Shi Q, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA. Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice. Int J Mol Sci. 2021 Dec 10; 22(24). PMID: 34948098.
    Citations:    Fields:    Translation:Animals
  4. Batista AF, Schroeder MK, Khan K, Li SA, Presumey J, Yalcin E, Carroll M, Lemere CA. Global C3 lowering alleviates hippocampal dysfunction and cognitive impairment in aged mice. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058736. PMID: 34971204.
    Citations:    Fields:    
  5. Bathini P, Sun T, Shi Q, Zhang Y, Taudte N, Schenk M, Hettmann T, Schilling S, McDannold N, Lemere CA. Focus Ultrasound-Induced Blood-Brain Barrier opening enhances anti-pGlu3 Aß mAb delivery and amyloid-beta plaque clearance. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058725. PMID: 34971185.
    Citations:    Fields:    
  6. Hoffmann T, Rahfeld JU, Schenk M, Ponath F, Makioka K, Hutter-Paier B, Lues I, Lemere CA, Schilling S. Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aß Pathology in Transgenic Mice. Int J Mol Sci. 2021 Oct 30; 22(21). PMID: 34769222; PMCID: PMC8584206.
    Citations:    Fields:    Translation:HumansAnimals
  7. Lemere CA, Head E, Holtzman DM. APOE e4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. JAMA Neurol. 2021 08 01; 78(8):913-915. PMID: 34228117.
    Citations: 1     Fields:    Translation:Humans
  8. Sun T, Shi Q, Zhang Y, Power C, Hoesch C, Antonelli S, Schroeder MK, Caldarone BJ, Taudte N, Schenk M, Hettmann T, Schilling S, McDannold NJ, Lemere CA. Focused ultrasound with anti-pGlu3 Aß enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells. J Control Release. 2021 08 10; 336:443-456. PMID: 34186148; PMCID: PMC8373822.
    Citations: 2     Fields:    Translation:HumansAnimals
  9. Cummings J, Aisen P, Lemere C, Atri A, Sabbagh M, Salloway S. Aducanumab produced a clinically meaningful benefit in association with amyloid lowering. Alzheimers Res Ther. 2021 05 10; 13(1):98. PMID: 33971962; PMCID: PMC8111757.
    Citations: 41     Fields:    Translation:Humans
  10. Kumar S, Lemere CA, Walter J. Phosphorylated Aß peptides in human Down syndrome brain and different Alzheimer's-like mouse models. Acta Neuropathol Commun. 2020 07 29; 8(1):118. PMID: 32727580.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Fu H, Liu B, Li L, Lemere CA. Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme. Neuroscience. 2020 09 01; 443:30-43. PMID: 32697980.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077. PMID: 32544310; PMCID: PMC8865308.
    Citations: 19     Fields:    Translation:Humans
  13. Knopman D, Lemere CA, Lamb BT, Craft S, Gitlin LN, Golde TE, Pericak-Vance M, Sano M, Schellenberg G, Schneider JA, Zheng H, Khachaturian Z, Snyder HM, Carrillo MC. Scientific Advising and Reviewing: On strengthening the bond between the Alzheimer's Association and the scientific community. Alzheimers Dement. 2020 07; 16(7):1095-1098. PMID: 32426924.
    Citations:    Fields:    Translation:Humans
  14. Hettmann T, Gillies SD, Kleinschmidt M, Piechotta A, Makioka K, Lemere CA, Schilling S, Rahfeld JU, Lues I. Development of the clinical candidate PBD-C06, a humanized pGlu3-Aß-specific antibody against Alzheimer's disease with reduced complement activation. Sci Rep. 2020 02 24; 10(1):3294. PMID: 32094456.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O'Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA. Effector function of anti-pyroglutamate-3 Aß antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice. Alzheimers Res Ther. 2020 01 13; 12(1):12. PMID: 31931873.
    Citations: 13     Fields:    Translation:AnimalsCells
  16. Whitaker KW, LaFerla FM, Steinbusch HWM, Lemere CA, Bovenkamp DE. BrightFocus Alzheimer's Fast Track 2019. Mol Neurodegener. 2019 12 20; 14(1):48. PMID: 31861987.
    Citations:    Fields:    Translation:Humans
  17. Liu B, Hinshaw RG, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Shi Q, Holton P, Trojanczyk L, Reiser V, Jones PA, Trigg W, Di Carli MF, Lorello P, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA. Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice. Sci Rep. 2019 08 20; 9(1):12118. PMID: 31431669.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  18. Lardenoije R, van den Hove DLA, Jung SE, Havermans M, Blackburn P, Liu B, Rutten BPF, Lemere CA. Active Amyloid-ß Vaccination Results in Epigenetic Changes in the Hippocampus of an Alzheimer's Disease-Like Mouse Model. Curr Alzheimer Res. 2019; 16(9):861-870. PMID: 31453788.
    Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
  19. Krukowski K, Chou A, Feng X, Tiret B, Paladini MS, Riparip LK, Chaumeil MM, Lemere C, Rosi S. Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits. Int J Mol Sci. 2018 Nov 26; 19(12). PMID: 30486287; PMCID: PMC6321529.
    Citations: 45     Fields:    Translation:AnimalsCells
  20. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2019 Jan; 9(6):279-286. PMID: 30800043; PMCID: PMC6381890.
    Citations: 3     
  21. Schilling S, Rahfeld JU, Lues I, Lemere CA. Passive Aß Immunotherapy: Current Achievements and Future Perspectives. Molecules. 2018 05 03; 23(5). PMID: 29751505.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  22. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. Deposition of phosphorylated amyloid-ß in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. PMID: 29740941.
    Citations: 3     Fields:    Translation:AnimalsCells
  23. Lardenoije R, van den Hove DLA, Havermans M, van Casteren A, Le KX, Palmour R, Lemere CA, Rutten BPF. Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease. Mol Cell Neurosci. 2018 01; 86:1-15. PMID: 29113959; PMCID: PMC6863355.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 09 19; 47(3):566-581.e9. PMID: 28930663.
    Citations: 706     Fields:    Translation:HumansAnimalsCells
  25. Shi Q, Chowdhury S, Ma R, Le KX, Hong S, Caldarone BJ, Stevens B, Lemere CA. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566429; PMCID: PMC6936623.
    Citations: 168     Fields:    Translation:AnimalsCells
  26. Lee HK, Kwon B, Lemere CA, de la Monte S, Itamura K, Ha AY, Querfurth HW. mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-ß Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons. J Alzheimers Dis. 2017; 56(3):1015-1036. PMID: 28035937; PMCID: PMC5577393.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  27. Larrick JW, Alfenito MR, Scott JK, Parren PW, Burton DR, Bradbury AR, Lemere CA, Messer A, Huston JS, Carter PJ, Veldman T, Chester KA, Schuurman J, Adams GP, Reichert JM. Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11-15, 2016, San Diego, CA. MAbs. 2016 Nov/Dec; 8(8):1425-1434. PMID: 27557809.
    Citations:    Fields:    Translation:HumansAnimals
  28. Cynis H, Frost JL, Crehan H, Lemere CA. Immunotherapy targeting pyroglutamate-3 Aß: prospects and challenges. Mol Neurodegener. 2016 06 30; 11(1):48. PMID: 27363697.
    Citations: 18     Fields:    Translation:HumansAnimals
  29. Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016 May 06; 352(6286):712-716. PMID: 27033548; PMCID: PMC5094372.
    Citations: 946     Fields:    Translation:AnimalsCells
  30. Head E, Lott IT, Wilcock DM, Lemere CA. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Curr Alzheimer Res. 2016; 13(1):18-29. PMID: 26651341.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  31. Liu B, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Lemere CA. In Vivo Detection of Age- and Disease-Related Increases in Neuroinflammation by 18F-GE180 TSPO MicroPET Imaging in Wild-Type and Alzheimer's Transgenic Mice. J Neurosci. 2015 Nov 25; 35(47):15716-30. PMID: 26609163; PMCID: PMC6705465.
    Citations: 56     Fields:    Translation:HumansAnimals
  32. Shi Q, Colodner KJ, Matousek SB, Merry K, Hong S, Kenison JE, Frost JL, Le KX, Li S, Dodart JC, Caldarone BJ, Stevens B, Lemere CA. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015 Sep 23; 35(38):13029-42. PMID: 26400934; PMCID: PMC6605437.
    Citations: 146     Fields:    Translation:AnimalsCells
  33. Frost JL, Liu B, Rahfeld JU, Kleinschmidt M, O'Nuallain B, Le KX, Lues I, Caldarone BJ, Schilling S, Demuth HU, Lemere CA. An anti-pyroglutamate-3 Aß vaccine reduces plaques and improves cognition in APPswe/PS1?E9 mice. Neurobiol Aging. 2015 Dec; 36(12):3187-3199. PMID: 26453001; PMCID: PMC4641825.
    Citations: 24     Fields:    Translation:Animals
  34. Mably AJ, Liu W, Mc Donald JM, Dodart JC, Bard F, Lemere CA, O'Nuallain B, Walsh DM. Anti-Aß antibodies incapable of reducing cerebral Aß oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiol Dis. 2015 Oct; 82:372-384. PMID: 26215784; PMCID: PMC4641028.
    Citations: 19     Fields:    Translation:HumansAnimals
  35. Janota C, Lemere CA, Brito MA. Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer's Disease. Mol Neurobiol. 2016 08; 53(6):3793-3811. PMID: 26143259.
    Citations: 25     Fields:    Translation:HumansAnimals
  36. Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch HW, Mastroeni D, Coleman P, Lemere CA, Hof PR, van den Hove DL, Rutten BP. The epigenetics of aging and neurodegeneration. Prog Neurobiol. 2015 Aug; 131:21-64. PMID: 26072273; PMCID: PMC6477921.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  37. Janota CS, Brites D, Lemere CA, Brito MA. Glio-vascular changes during ageing in wild-type and Alzheimer's disease-like APP/PS1 mice. Brain Res. 2015 Sep 16; 1620:153-68. PMID: 25966615; PMCID: PMC4549169.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  38. Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM. Tau immunization: a cautionary tale? Neurobiol Aging. 2015 Mar; 36(3):1316-32. PMID: 25619661.
    Citations: 16     Fields:    Translation:Animals
  39. Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9. PMID: 25510383.
    Citations: 106     Fields:    Translation:HumansAnimals
  40. An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH. Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo. Mol Brain. 2013 Nov 13; 6:47. PMID: 24284042.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  41. Lemere CA. Immunotherapy for Alzheimer's disease: hoops and hurdles. Mol Neurodegener. 2013 Oct 22; 8:36. PMID: 24148220.
    Citations: 71     Fields:    Translation:HumansAnimals
  42. Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. PMID: 23747948; PMCID: PMC3730768.
    Citations: 52     Fields:    Translation:HumansAnimals
  43. Liu B, Frost JL, Sun J, Fu H, Grimes S, Blackburn P, Lemere CA. MER5101, a novel Aß1-15:DT conjugate vaccine, generates a robust anti-Aß antibody response and attenuates Aß pathology and cognitive deficits in APPswe/PS1?E9 transgenic mice. J Neurosci. 2013 Apr 17; 33(16):7027-37. PMID: 23595760.
    Citations: 24     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  44. Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet. 2013 Aug 01; 22(15):3077-92. PMID: 23585551.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  45. Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. Galactic cosmic radiation leads to cognitive impairment and increased aß plaque accumulation in a mouse model of Alzheimer's disease. PLoS One. 2012; 7(12):e53275. PMID: 23300905.
    Citations: 62     Fields:    Translation:Animals
  46. Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aß by microglia. Glia. 2012 May; 60(6):993-1003. PMID: 22438044.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  47. Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR, Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, Evans DA, Bennett DA, De Jager PL. A coding variant in CR1 interacts with APOE-e4 to influence cognitive decline. Hum Mol Genet. 2012 May 15; 21(10):2377-88. PMID: 22343410; PMCID: PMC3335317.
    Citations: 53     Fields:    Translation:Humans
  48. Frost JL, Liu B, Kleinschmidt M, Schilling S, Demuth HU, Lemere CA. Passive immunization against pyroglutamate-3 amyloid-ß reduces plaque burden in Alzheimer-like transgenic mice: a pilot study. Neurodegener Dis. 2012; 10(1-4):265-70. PMID: 22343072.
    Citations: 31     Fields:    Translation:HumansAnimals
  49. Lee S, Lemere CA, Frost JL, Shea TB. Dietary supplementation with S-adenosyl methionine delayed amyloid-ß and tau pathology in 3xTg-AD mice. J Alzheimers Dis. 2012; 28(2):423-31. PMID: 22045486.
    Citations: 19     Fields:    Translation:HumansAnimals
  50. Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther. 2011 Jan 06; 3(1):1. PMID: 21211070; PMCID: PMC3109410.
    Citations: 200     Fields:    
  51. Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease. J Neurosci. 2010 Jun 16; 30(24):8180-9. PMID: 20554868.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  52. Fu HJ, Liu B, Frost JL, Lemere CA. Amyloid-beta immunotherapy for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010 Apr; 9(2):197-206. PMID: 20205640.
    Citations: 29     Fields:    Translation:HumansAnimalsPHPublic Health
  53. Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol. 2010 Feb; 6(2):108-19. PMID: 20140000.
    Citations: 150     Fields:    Translation:HumansAnimals
  54. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X. L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol. 2009 Oct 25; 621(1-3):38-45. PMID: 19737553.
    Citations: 20     Fields:    Translation:AnimalsCells
  55. Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov; 36(2):293-302. PMID: 19660551.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  56. Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T. Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12145-50. PMID: 19581601.
    Citations: 79     Fields:    Translation:AnimalsCellsPHPublic Health
  57. Kadokura A, Yamazaki T, Kakuda S, Makioka K, Lemere CA, Fujita Y, Takatama M, Okamoto K. Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration. Neurosci Lett. 2009 Sep 29; 463(1):87-92. PMID: 19539703.
    Citations: 14     Fields:    Translation:HumansCells
  58. Kadokura A, Yamazaki T, Lemere CA, Takatama M, Okamoto K. Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathology. Neuropathology. 2009 Oct; 29(5):566-73. PMID: 19422539.
    Citations: 42     Fields:    Translation:HumansCells
  59. Baulac S, Lu H, Strahle J, Yang T, Goldberg MS, Shen J, Schlossmacher MG, Lemere CA, Lu Q, Xia W. Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Mol Neurodegener. 2009 Feb 25; 4:12. PMID: 19243613.
    Citations: 25     Fields:    
  60. Lemere CA. Developing novel immunogens for a safe and effective Alzheimer's disease vaccine. Prog Brain Res. 2009; 175:83-93. PMID: 19660650.
    Citations: 38     Fields:    Translation:HumansAnimals
  61. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42. PMID: 18568035.
    Citations: 1638     Fields:    Translation:HumansAnimalsCells
  62. Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18; 28(25):6333-41. PMID: 18562603.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  63. Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci. 2008 Apr 16; 28(16):4231-7. PMID: 18417702.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  64. Lemere CA, Oh J, Stanish HA, Peng Y, Pepivani I, Fagan AM, Yamaguchi H, Westmoreland SV, Mansfield KG. Cerebral amyloid-beta protein accumulation with aging in cotton-top tamarins: a model of early Alzheimer's disease? Rejuvenation Res. 2008 Apr; 11(2):321-32. PMID: 18341428.
    Citations: 20     Fields:    Translation:HumansAnimals
  65. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X. l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett. 2008 Mar 28; 434(2):224-9. PMID: 18328624.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  66. Kondo Y, Lemere CA, Seabrook TJ. Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. J Neuroinflammation. 2007 Dec 20; 4:31. PMID: 18093340.
    Citations: 16     Fields:    Translation:AnimalsCells
  67. Peng Y, Lee DY, Jiang L, Ma Z, Schachter SC, Lemere CA. Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. Neuroscience. 2007 Dec 05; 150(2):386-95. PMID: 17945434.
    Citations: 16     Fields:    Translation:HumansCells
  68. Lemere CA, Maier M, Peng Y, Jiang L, Seabrook TJ. Novel Abeta immunogens: is shorter better? Curr Alzheimer Res. 2007 Sep; 4(4):427-36. PMID: 17908047.
    Citations: 17     Fields:    Translation:HumansAnimals
  69. He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R, Shen Y. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol. 2007 Aug 27; 178(5):829-41. PMID: 17724122; PMCID: PMC2064547.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  70. Lemere CA. A beneficial role for IL-1 beta in Alzheimer disease? J Clin Invest. 2007 Jun; 117(6):1483-5. PMID: 17549252; PMCID: PMC1878536.
    Citations: 5     Fields:    Translation:HumansAnimals
  71. Peng Y, Jiang L, Lee DY, Schachter SC, Ma Z, Lemere CA. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells. J Neurosci Res. 2006 Sep; 84(4):903-11. PMID: 16862548.
    Citations: 15     Fields:    Translation:HumansCells
  72. Seabrook TJ, Jiang L, Thomas K, Lemere CA. Boosting with intranasal dendrimeric Abeta1-15 but not Abeta1-15 peptide leads to an effective immune response following a single injection of Abeta1-40/42 in APP-tg mice. J Neuroinflammation. 2006 Jun 05; 3:14. PMID: 16753065.
    Citations: 10     Fields:    
  73. Liu K, Solano I, Mann D, Lemere C, Mercken M, Trojanowski JQ, Lee VM. Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease. Acta Neuropathol. 2006 Aug; 112(2):163-74. PMID: 16865398.
    Citations: 33     Fields:    Translation:Humans
  74. Seabrook TJ, Thomas K, Jiang L, Bloom J, Spooner E, Maier M, Bitan G, Lemere CA. Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice. Neurobiol Aging. 2007 Jun; 28(6):813-23. PMID: 16725229.
    Citations: 27     Fields:    Translation:HumansAnimals
  75. Maier M, Seabrook TJ, Lazo ND, Jiang L, Das P, Janus C, Lemere CA. Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. J Neurosci. 2006 May 03; 26(18):4717-28. PMID: 16672644.
    Citations: 62     Fields:    Translation:AnimalsCells
  76. Seabrook TJ, Jiang L, Maier M, Lemere CA. Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia. 2006 May; 53(7):776-82. PMID: 16534778.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  77. Lemere CA, Maier M, Jiang L, Peng Y, Seabrook TJ. Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans. Rejuvenation Res. 2006; 9(1):77-84. PMID: 16608400.
    Citations: 23     Fields:    Translation:HumansAnimalsPHPublic Health
  78. Maier M, Seabrook TJ, Lemere CA. Modulation of the humoral and cellular immune response in Abeta immunotherapy by the adjuvants monophosphoryl lipid A (MPL), cholera toxin B subunit (CTB) and E. coli enterotoxin LT(R192G). Vaccine. 2005 Oct 25; 23(44):5149-59. PMID: 16054274.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  79. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May; 11(5):556-61. PMID: 15834427.
    Citations: 199     Fields:    Translation:AnimalsCellsPHPublic Health
  80. Maier M, Seabrook TJ, Lemere CA. Developing novel immunogens for an effective, safe Alzheimer's disease vaccine. Neurodegener Dis. 2005; 2(5):267-72. PMID: 16909008.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  81. Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA. Species-specific immune response to immunization with human versus rodent A beta peptide. Neurobiol Aging. 2004 Oct; 25(9):1141-51. PMID: 15312960.
    Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  82. Seabrook TJ, Iglesias M, Bloom JK, Spooner ET, Lemere CA. Differences in the immune response to long term Abeta vaccination in C57BL/6 and B6D2F1 mice. Vaccine. 2004 Sep 28; 22(29-30):4075-83. PMID: 15364459.
    Citations: 10     Fields:    Translation:AnimalsPHPublic Health
  83. Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem. 2004 Nov 05; 279(45):46907-14. PMID: 15345711.
    Citations: 72     Fields:    Translation:AnimalsCells
  84. Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin FR. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol. 2004 Jul; 165(1):283-97. PMID: 15215183; PMCID: PMC1618542.
    Citations: 91     Fields:    Translation:HumansAnimals
  85. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K. A seed for Alzheimer amyloid in the brain. J Neurosci. 2004 May 19; 24(20):4894-902. PMID: 15152051; PMCID: PMC6729458.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  86. Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET. Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mech Ageing Dev. 2004 Feb; 125(2):149-51. PMID: 15037022.
    Citations: 11     Fields:    Translation:Animals
  87. Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET. Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Dis Assoc Disord. 2004 Jan-Mar; 18(1):44-6. PMID: 15195463.
    Citations: 10     Fields:    Translation:AnimalsPHPublic Health
  88. Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH. APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol. 2003 Oct 13; 163(1):83-95. PMID: 14557249; PMCID: PMC2173445.
    Citations: 175     Fields:    Translation:HumansCells
  89. Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiol Dis. 2003 Oct; 14(1):10-8. PMID: 13678662.
    Citations: 55     Fields:    Translation:AnimalsPHPublic Health
  90. Lemere CA, Spooner ET, Leverone JF, Mori C, Iglesias M, Bloom JK, Seabrook TJ. Amyloid-beta immunization in Alzheimer's disease transgenic mouse models and wildtype mice. Neurochem Res. 2003 Jul; 28(7):1017-27. PMID: 12737526.
    Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
  91. Leverone JF, Spooner ET, Lehman HK, Clements JD, Lemere CA. Abeta1-15 is less immunogenic than Abeta1-40/42 for intranasal immunization of wild-type mice but may be effective for "boosting". Vaccine. 2003 May 16; 21(17-18):2197-206. PMID: 12706711.
    Citations: 15     Fields:    Translation:HumansAnimals
  92. Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid. 2003 Mar; 10(1):51-61. PMID: 12762144.
    Citations:    Fields:    Translation:HumansAnimals
  93. Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci. 2003 Jan 01; 23(1):29-33. PMID: 12514198; PMCID: PMC6742136.
    Citations: 108     Fields:    Translation:Animals
  94. Spooner ET, Desai RV, Mori C, Leverone JF, Lemere CA. The generation and characterization of potentially therapeutic Abeta antibodies in mice: differences according to strain and immunization protocol. Vaccine. 2002 Dec 13; 21(3-4):290-7. PMID: 12450704.
    Citations: 17     Fields:    Translation:AnimalsPHPublic Health
  95. Lemere CA, Spooner ET, Leverone JF, Mori C, Clements JD. Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants. Neurobiol Aging. 2002 Nov-Dec; 23(6):991-1000. PMID: 12470794.
    Citations: 27     Fields:    Translation:AnimalsCells
  96. Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid. 2002 Jun; 9(2):88-102. PMID: 12440481.
    Citations: 96     Fields:    Translation:HumansCells
  97. Lemere CA, Maron R, Selkoe DJ, Weiner HL. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol. 2001 Nov; 20(11):705-11. PMID: 11788048.
    Citations: 31     Fields:    Translation:Animals
  98. Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2001 Apr; 158(4):1345-54. PMID: 11290552; PMCID: PMC1891893.
    Citations: 89     Fields:    Translation:AnimalsCells
  99. Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol. 2000 Oct; 48(4):567-79. PMID: 11026440.
    Citations: 85     Fields:    Translation:HumansAnimals
  100. Kokubo H, Lemere CA, Yamaguchi H. Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology. Neurosci Lett. 2000 Aug 25; 290(2):93-6. PMID: 10936685.
    Citations: 11     Fields:    Translation:HumansCells
  101. Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. Am J Pathol. 2000 Feb; 156(2):489-99. PMID: 10666378; PMCID: PMC1850044.
    Citations: 66     Fields:    Translation:Humans
  102. Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann N Y Acad Sci. 2000; 920:328-31. PMID: 11193172.
    Citations: 34     Fields:    Translation:HumansAnimals
  103. Zhen W, Han H, Anguiano M, Lemere CA, Cho CG, Lansbury PT. Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain. J Med Chem. 1999 Jul 29; 42(15):2805-15. PMID: 10425090.
    Citations: 11     Fields:    Translation:Humans
  104. Lemere CA, Grenfell TJ, Selkoe DJ. The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome. Am J Pathol. 1999 Jul; 155(1):29-37. PMID: 10393833; PMCID: PMC1866646.
    Citations: 4     Fields:    Translation:HumansAnimals
  105. Fulton AB, Reynaud X, Hansen RM, Lemere CA, Parker C, Williams TP. Rod photoreceptors in infant rats with a history of oxygen exposure. Invest Ophthalmol Vis Sci. 1999 Jan; 40(1):168-74. PMID: 9888440.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  106. Lopera F, Ardilla A, Martínez A, Madrigal L, Arango-Viana JC, Lemere CA, Arango-Lasprilla JC, Hincapíe L, Arcos-Burgos M, Ossa JE, Behrens IM, Norton J, Lendon C, Goate AM, Ruiz-Linares A, Rosselli M, Kosik KS. Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation. JAMA. 1997 Mar 12; 277(10):793-9. PMID: 9052708.
    Citations: 105     Fields:    Translation:Humans
  107. Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. J Biol Chem. 1996 Dec 27; 271(52):33623-31. PMID: 8969231.
    Citations: 43     Fields:    Translation:Humans
  108. Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango JC. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med. 1996 Oct; 2(10):1146-50. PMID: 8837617.
    Citations: 111     Fields:    Translation:HumansCells
  109. Yamaguchi H, Ishiguro K, Uchida T, Takashima A, Lemere CA, Imahori K. Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II. Acta Neuropathol. 1996 Sep; 92(3):232-41. PMID: 8870824.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  110. Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol Dis. 1996 Feb; 3(1):51-63. PMID: 9173912.
    Citations: 76     Fields:    Translation:HumansCells
  111. Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis. 1996 Feb; 3(1):16-32. PMID: 9173910.
    Citations: 183     Fields:    Translation:HumansCells
  112. Schmidt JT, Lemere CA. Rapid activity-dependent sprouting of optic fibers into a local area denervated by application of beta-bungarotoxin in goldfish tectum. J Neurobiol. 1996 Jan; 29(1):75-90. PMID: 8748373.
    Citations:    Fields:    Translation:Animals
  113. Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med. 1995 Dec; 1(12):1291-6. PMID: 7489411.
    Citations: 179     Fields:    Translation:HumansCells
  114. Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. Biochem J. 1995 Oct 01; 311 ( Pt 1):299-305. PMID: 7575468; PMCID: PMC1136152.
    Citations: 21     Fields:    Translation:HumansCells
  115. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am J Pathol. 1995 Apr; 146(4):848-60. PMID: 7717452; PMCID: PMC1869262.
    Citations: 25     Fields:    Translation:Humans
  116. Shi GP, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15; 269(15):11530-6. PMID: 8157683.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  117. Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol. 1992 Jul; 141(1):249-59. PMID: 1632466; PMCID: PMC1886563.
    Citations: 41     Fields:    Translation:HumansCells
  118. Hansen LA, Natelson BH, Lemere C, Niemann W, De Teresa R, Regan TJ, Masliah E, Terry RD. Alcohol-induced brain changes in dogs. Arch Neurol. 1991 Sep; 48(9):939-42. PMID: 1953418.
    Citations: 4     Fields:    Translation:Animals
  119. Wiley CA, Masliah E, Morey M, Lemere C, DeTeresa R, Grafe M, Hansen L, Terry R. Neocortical damage during HIV infection. Ann Neurol. 1991 Jun; 29(6):651-7. PMID: 1909852.
    Citations: 110     Fields:    Translation:HumansCells
  120. Murphey RK, Lemere CA. Competition controls the growth of an identified axonal arborization. Science. 1984 Jun 22; 224(4655):1352-5. PMID: 6729457.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.