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Thomas Heldt, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Imaduddin SM, Sodini CG, Heldt T. Deconvolution-Based Partial Volume Correction for Volumetric Blood Flow Measurement. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 08; 69(8):2484-2498. PMID: 35793303.
    Citations:    Fields:    
  2. Prasad V, Reisner AT, Lynch JC, Filbin MR, Heldt T. Modeling of Usual Care: Vasopressor Initiation for Sepsis With Hypotension. Front Med (Lausanne). 2022; 9:715856. PMID: 35360743; PMCID: PMC8963410.
    Citations:    
  3. Lai HY, Saavedra-Pena G, Sodini C, Heldt T, Sze V. App-Based Saccade Latency and Directional Error Determination Across the Adult Age Spectrum. IEEE Trans Biomed Eng. 2022 02; 69(2):1029-1039. PMID: 34529556.
    Citations:    Fields:    Translation:Humans
  4. Kussman BD, Imaduddin SM, Gharedaghi MH, Heldt T, LaRovere K. Cerebral Emboli Monitoring Using Transcranial Doppler Ultrasonography in Adults and Children: A Review of the Current Technology and Clinical Applications in the Perioperative and Intensive Care Setting. Anesth Analg. 2021 08 01; 133(2):379-392. PMID: 33764341.
    Citations: 1     Fields:    Translation:Humans
  5. Teichmann D, Lynch JC, Heldt T. Distortion of the Intracranial Pressure Waveform by Extraventricular Drainage System. IEEE Trans Biomed Eng. 2021 05; 68(5):1646-1657. PMID: 33156777.
    Citations: 2     Fields:    
  6. Iwasaki KI, Ogawa Y, Kurazumi T, Imaduddin SM, Mukai C, Furukawa S, Yanagida R, Kato T, Konishi T, Shinojima A, Levine BD, Heldt T. Long-duration spaceflight alters estimated intracranial pressure and cerebral blood velocity. J Physiol. 2021 02; 599(4):1067-1081. PMID: 33103234.
    Citations: 5     Fields:    Translation:Humans
  7. Wadehn F, Heldt T. Adaptive Maximal Blood Flow Velocity Estimation From Transcranial Doppler Echos. IEEE J Transl Eng Health Med. 2020; 8:1800511. PMID: 33033664.
    Citations: 1     Fields:    
  8. Aydemir B, Prasad V, Lynch JC, Biebelberg B, Kehoe I, Reisner AT, Heldt T. Validation of a 'Usual Care' Model for Vasopressor Initiation in a Cohort of Emergency Department Patients with Sepsis. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:2772-2775. PMID: 33018581.
    Citations:    Fields:    Translation:Humans
  9. Jaishankar R, Fanelli A, Filippidis A, Vu T, Holsapple J, Heldt T. A Spectral Approach to Model-Based Noninvasive Intracranial Pressure Estimation. IEEE J Biomed Health Inform. 2020 08; 24(8):2398-2406. PMID: 31880569.
    Citations: 3     Fields:    Translation:Humans
  10. Filbin MR, Thorsen JE, Zachary TM, Lynch JC, Matsushima M, Belsky JB, Heldt T, Reisner AT. Antibiotic Delays and Feasibility of a 1-Hour-From-Triage Antibiotic Requirement: Analysis of an Emergency Department Sepsis Quality Improvement Database. Ann Emerg Med. 2020 01; 75(1):93-99. PMID: 31561998.
    Citations: 9     Fields:    Translation:Humans
  11. M Imaduddin S, Fanelli A, Vonberg FW, Tasker RC, Heldt T. Pseudo-Bayesian Model-Based Noninvasive Intracranial Pressure Estimation and Tracking. IEEE Trans Biomed Eng. 2020 06; 67(6):1604-1615. PMID: 31535978.
    Citations: 5     Fields:    Translation:Humans
  12. Fanelli A, Vonberg FW, LaRovere KL, Walsh BK, Smith ER, Robinson S, Tasker RC, Heldt T. Fully automated, real-time, calibration-free, continuous noninvasive estimation of intracranial pressure in children. J Neurosurg Pediatr. 2019 Aug 23; 1-11. PMID: 31443086.
    Citations: 8     Fields:    
  13. Diaz-Artiles A, Heldt T, Young LR. Computational model of cardiovascular response to centrifugation and lower body cycling exercise. J Appl Physiol (1985). 2019 11 01; 127(5):1453-1468. PMID: 31343946.
    Citations: 3     Fields:    Translation:Humans
  14. Imaduddin SM, LaRovere KL, Kussman BD, Heldt T. A Time-Frequency Approach for Cerebral Embolic Load Monitoring. IEEE Trans Biomed Eng. 2020 04; 67(4):1007-1018. PMID: 31295101.
    Citations:    Fields:    Translation:Humans
  15. Gu Q, Prasad V, Heldt T. Characterizing Fluid Response and Sepsis Progression in Emergency Department Patients. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:510-513. PMID: 31945949.
    Citations:    Fields:    Translation:Humans
  16. Jaishankar R, Fanelli A, Filippidis A, Vu T, Holsapple J, Heldt T. A Frequency-domain Approach to Noninvasive Intracranial Pressure Estimation. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:5055-5058. PMID: 31946995.
    Citations:    Fields:    Translation:Humans
  17. Prasad V, Lynch JC, Filbin MR, Reisner AT, Heldt T. Clustering Blood Pressure Trajectories in Septic Shock in the Emergency Department. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:494-497. PMID: 31945945.
    Citations:    Fields:    Translation:Humans
  18. Heldt T, Zoerle T, Teichmann D, Stocchetti N. Intracranial Pressure and Intracranial Elastance Monitoring in Neurocritical Care. Annu Rev Biomed Eng. 2019 06 04; 21:523-549. PMID: 31167100.
    Citations: 11     Fields:    Translation:Humans
  19. Wadehn F, Weber T, Mack DJ, Heldt T, Loeliger HA. Model-Based Separation, Detection, and Classification of Eye Movements. IEEE Trans Biomed Eng. 2020 02; 67(2):588-600. PMID: 31150326.
    Citations: 1     Fields:    Translation:HumansAnimals
  20. Lai HY, Saavedra-Pena G, Sodini CG, Sze V, Heldt T. Measuring Saccade Latency Using Smartphone Cameras. IEEE J Biomed Health Inform. 2020 03; 24(3):885-897. PMID: 31056528.
    Citations: 2     Fields:    Translation:Humans
  21. Filbin MR, Heldt T, Reisner AT. The authors reply. Crit Care Med. 2018 12; 46(12):e1222-e1223. PMID: 30444821.
    Citations:    Fields:    Translation:Humans
  22. Birjiniuk J, Heldt T. Tracking autonomic balance using an open-loop model of the arterial baroreflex. Am J Physiol Regul Integr Comp Physiol. 2019 02 01; 316(2):R121-R129. PMID: 30462526.
    Citations: 1     Fields:    Translation:Humans
  23. Diaz-Artiles A, Heldt T, Young LR. Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise. Front Physiol. 2018; 9:1492. PMID: 30483141; PMCID: PMC6242912.
    Citations: 9     
  24. Filbin MR, Lynch J, Gillingham TD, Thorsen JE, Pasakarnis CL, Nepal S, Matsushima M, Rhee C, Heldt T, Reisner AT. Presenting Symptoms Independently Predict Mortality in Septic Shock: Importance of a Previously Unmeasured Confounder. Crit Care Med. 2018 10; 46(10):1592-1599. PMID: 29965833.
    Citations: 38     Fields:    Translation:Humans
  25. Jinadasa SP, Mueller A, Prasad V, Subramaniam K, Heldt T, Novack V, Subramaniam B. Blood Pressure Coefficient of Variation and Its Association With Cardiac Surgical Outcomes. Anesth Analg. 2018 10; 127(4):832-839. PMID: 29624524.
    Citations: 12     Fields:    Translation:Humans
  26. Li T, Matsushima M, Timpson W, Young S, Miedema D, Gupta M, Heldt T. Correction: Epidemiology of patient monitoring alarms in the neonatal intensive care unit. J Perinatol. 2018 Aug; 38(8):1124. PMID: 30046177.
    Citations:    Fields:    
  27. Filbin MR, Thorsen JE, Lynch J, Gillingham TD, Pasakarnis CL, Capp R, Shapiro NI, Mooncai T, Hou PC, Heldt T, Reisner AT. Challenges and Opportunities for Emergency Department Sepsis Screening at Triage. Sci Rep. 2018 07 23; 8(1):11059. PMID: 30038408.
    Citations: 7     Fields:    Translation:Humans
  28. Saavedra-Pena G, Lai HY, Sze V, Heldt T. Determination of Saccade Latency Distributions using Video Recordings from Consumer-grade Devices. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:953-956. PMID: 30440548.
    Citations:    Fields:    Translation:Humans
  29. Karasan E, Abid A, Mieloszyk RJ, Krauss BS, Heldt T, Verghese GC. An Enhanced Mechanistic Model For Capnography, With Application To CHF-COPD Discrimination. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:5267-5272. PMID: 30441526.
    Citations:    Fields:    Translation:Humans
  30. Birjiniuk J, Gordhandas AJ, Verghese GC, Heldt T. A Fiducial Scaffold for ECG Compression in Low-Powered Devices. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1-4. PMID: 30440279.
    Citations:    Fields:    
  31. Shim EB, Heldt T. Fluid-structure Interaction in the Cerebral Venous Transverse Sinus. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:4544-4547. PMID: 30441362.
    Citations: 1     Fields:    Translation:Humans
  32. Li T, Matsushima M, Timpson W, Young S, Miedema D, Gupta M, Heldt T. Epidemiology of patient monitoring alarms in the neonatal intensive care unit. J Perinatol. 2018 08; 38(8):1030-1038. PMID: 29740183.
    Citations: 6     Fields:    Translation:Humans
  33. Matthews JM, Fanelli A, Heldt T. An Embedded Device for Real-Time Noninvasive Intracranial Pressure Estimation. Acta Neurochir Suppl. 2018; 126:85-88. PMID: 29492538.
    Citations:    Fields:    Translation:Humans
  34. Fanelli A, Jaishankar R, Filippidis A, Holsapple J, Heldt T. A Waveform Archiving System for the GE Solar 8000i Bedside Monitor. Acta Neurochir Suppl. 2018; 126:173-177. PMID: 29492556.
    Citations:    Fields:    Translation:Humans
  35. Prasad V, Guerrisi M, Dauri M, Coniglione F, Tisone G, De Carolis E, Cillis A, Canichella A, Toschi N, Heldt T. Prediction of postoperative outcomes using intraoperative hemodynamic monitoring data. Sci Rep. 2017 11 27; 7(1):16376. PMID: 29180647.
    Citations: 5     Fields:    Translation:Humans
  36. Dekimpe R, Heldt T. Reducing false asystole alarms in intensive care. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:2292-2295. PMID: 29060355.
    Citations:    Fields:    Translation:Humans
  37. Mieloszyk RJ, Krauss BS, Montagu D, Andolfatto G, Barbi E, Verghese GC, Heldt T. Statistical analysis of the age dependence of the normal capnogram. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:345-348. PMID: 29059881.
    Citations:    Fields:    Translation:Humans
  38. Prasad V, Lynch JC, Pasakarnis CL, Thorsen JE, Filbin MR, Reisner AT, Heldt T. Classification models to predict vasopressor administration for septic shock in the emergency department. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:2650-2653. PMID: 29060444.
    Citations:    Fields:    Translation:Humans
  39. Imaduddin SM, Heldt T. Model-based estimation of radial artery blood pressure from recordings of the Nexfin monitor. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:1692-1695. PMID: 29060211.
    Citations:    Fields:    Translation:Humans
  40. Fanelli A, Vonberg FW, Jaishankar R, Imaduddin SM, Tasker RC, Heldt T. Regression-based noninvasive estimation of intracranial pressure. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:4001-4004. PMID: 29060774.
    Citations:    Fields:    Translation:Humans
  41. Abid A, Mieloszyk RJ, Verghese GC, Krauss BS, Heldt T. Model-Based Estimation of Respiratory Parameters from Capnography, With Application to Diagnosing Obstructive Lung Disease. IEEE Trans Biomed Eng. 2017 12; 64(12):2957-2967. PMID: 28475040.
    Citations: 3     Fields:    Translation:Humans
  42. Noraky J, Verghese GC, Searls DE, Lioutas VA, Sonni S, Thomas A, Heldt T. Noninvasive Intracranial Pressure Determination in Patients with Subarachnoid Hemorrhage. Acta Neurochir Suppl. 2016; 122:65-8. PMID: 27165879.
    Citations: 2     Fields:    Translation:Humans
  43. Abid A, Mieloszyk RJ, Verghese GC, Krauss BS, Heldt T. Model-based estimation of pulmonary compliance and resistance parameters from time-based capnography. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:1687-90. PMID: 26736601.
    Citations:    Fields:    Translation:Humans
  44. Prasad V, Toschi N, Canichella A, Marcellucci M, Coniglione F, Dauri M, Guerrisi M, Heldt T. Intraoperative hemodynamics predict postoperative mortality in orthotopic liver transplantation. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:989-92. PMID: 26736430.
    Citations: 1     Fields:    Translation:Humans
  45. Mieloszyk RJ, Guo MG, Verghese GC, Andolfatto G, Heldt T, Krauss BS. Clustering of capnogram features to track state transitions during procedural sedation. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:1699-702. PMID: 26736604.
    Citations: 1     Fields:    Translation:Humans
  46. Dunitz M, Verghese G, Heldt T. Predicting hyperlactatemia in the MIMIC II database. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:985-8. PMID: 26736429.
    Citations: 3     Fields:    Translation:Humans
  47. Mieloszyk RJ, Verghese GC, Deitch K, Cooney B, Khalid A, Mirre-Gonzalez MA, Heldt T, Krauss BS. Automated quantitative analysis of capnogram shape for COPD-normal and COPD-CHF classification. IEEE Trans Biomed Eng. 2014 Dec; 61(12):2882-90. PMID: 24967981.
    Citations: 5     Fields:    Translation:Humans
  48. Subramaniam B, Khabbaz KR, Heldt T, Lerner AB, Mittleman MA, Davis RB, Goldberger AL, Costa MD. Blood pressure variability: can nonlinear dynamics enhance risk assessment during cardiovascular surgery? J Cardiothorac Vasc Anesth. 2014 Apr; 28(2):392-7. PMID: 24508020.
    Citations: 11     Fields:    Translation:Humans
  49. Ranger M, Celeste Johnston C, Rennick JE, Limperopoulos C, Heldt T, du Plessis AJ. A multidimensional approach to pain assessment in critically ill infants during a painful procedure. Clin J Pain. 2013 Jul; 29(7):613-20. PMID: 23328334.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  50. Reisner AT, Heldt T. A computational model of hemorrhage and dehydration suggests a pathophysiological mechanism: Starling-mediated protein trapping. Am J Physiol Heart Circ Physiol. 2013 Feb 15; 304(4):H620-31. PMID: 23203962.
    Citations: 5     Fields:    Translation:HumansAnimals
  51. Shim EB, Heldt T, Amano A, Rhee K. Computational analysis of cardiovascular hemodynamics. Comput Math Methods Med. 2012; 2012:260396. PMID: 22991576.
    Citations:    Fields:    Translation:Humans
  52. Kashif FM, Verghese GC, Novak V, Czosnyka M, Heldt T. Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial pressure. Sci Transl Med. 2012 Apr 11; 4(129):129ra44. PMID: 22496546; PMCID: PMC4010388.
    Citations: 26     Fields:    Translation:Humans
  53. Heldt T, Kashif FM, Sulemanji M, O'Leary HM, du Plessis AJ, Verghese GC. Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings. Acta Neurochir Suppl. 2012; 114:177-80. PMID: 22327688.
    Citations: 4     Fields:    Translation:Humans
  54. Saeed M, Villarroel M, Reisner AT, Clifford G, Lehman LW, Moody G, Heldt T, Kyaw TH, Moody B, Mark RG. Multiparameter Intelligent Monitoring in Intensive Care II: a public-access intensive care unit database. Crit Care Med. 2011 May; 39(5):952-60. PMID: 21283005; PMCID: PMC3124312.
    Citations: 261     Fields:    Translation:Humans
  55. Haslam B, Gordhandas A, Ricciardi C, Verghese G, Heldt T. Distilling clinically interpretable information from data collected on next-generation wearable sensors. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1729-32. PMID: 22254660.
    Citations:    Fields:    Translation:Humans
  56. Heldt T, Mukkamala R, Moody GB, Mark RG. CVSim: An Open-Source Cardiovascular Simulator for Teaching and Research. Open Pacing Electrophysiol Ther J. 2010; 3:45-54. PMID: 21949555.
    Citations: 7     
  57. Heldt T, Verghese GC. Model-based data integration in clinical environments. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:5209-12. PMID: 21095826.
    Citations: 1     Fields:    Translation:Humans
  58. He DD, Winokur ES, Heldt T, Sodini CG. The ear as a location for wearable vital signs monitoring. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:6389-92. PMID: 21096700.
    Citations: 5     Fields:    Translation:Humans
  59. Sun JX, Reisner AT, Saeed M, Heldt T, Mark RG. The cardiac output from blood pressure algorithms trial. Crit Care Med. 2009 Jan; 37(1):72-80. PMID: 19112280; PMCID: PMC3107992.
    Citations: 21     Fields:    Translation:Humans
  60. Heldt T. Continuous blood pressure-derived cardiac output monitoring--should we be thinking long term? J Appl Physiol (1985). 2006 Aug; 101(2):373-4. PMID: 16690788.
    Citations: 4     Fields:    Translation:Humans
  61. Heldt T, Long B, Verghese GC, Szolovits P, Mark RG. Integrating data, models, and reasoning in critical care. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:350-3. PMID: 17946818.
    Citations: 7     Fields:    Translation:Humans
  62. Roberts JM, Parlikar TA, Heldt T, Verghese GC. Bayesian networks for cardiovascular monitoring. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:205-9. PMID: 17946804.
    Citations: 2     Fields:    Translation:Humans
  63. Heldt T, Chang JL, Chen JJ, Verghese GC, Mark RG. Cycle-averaged dynamics of a periodically driven, closed-loop circulation model. Control Eng Pract. 2005 Sep; 13(9):1163-71. PMID: 16050064.
    Citations: 3     
  64. Heldt T, Shim EB, Kamm RD, Mark RG. Computational modeling of cardiovascular response to orthostatic stress. J Appl Physiol (1985). 2002 Mar; 92(3):1239-54. PMID: 11842064.
    Citations: 46     Fields:    Translation:Humans
  65. Heldt T, Shim EB, Kamm RD, Mark RG. Model-based parameter estimation using cardiovascular response to orthostatic stress. Comput Cardiol. 2001; 28:337-40. PMID: 14640093.
    Citations:    Translation:Humans
  66. Heldt T, Shim EB, Kamm RD, Mark RG. Computational model of cardiovascular function during orthostatic stress. Comput Cardiol. 2000; 27:777-80. PMID: 11806418.
    Citations: 2     Translation:Humans
  67. Shim EB, Kamm RD, Heldt T, Mark RG. Numerical analysis of blood flow through a stenosed artery using a coupled, multiscale simulation method. Comput Cardiol. 2000; 27:219-22. PMID: 12085933.
    Citations: 2     Translation:Humans
  68. Heldt T, Shim EB, Kamm RD, Mark RG. Computational models of cardiovascular function for analysis of post-flight orthostatic intolerance. Comput Cardiol. 1999; 26:213-6. PMID: 11795340.
    Citations:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.