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Thomas Heldt, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jaishankar R, Fanelli A, Filippidis A, Vu T, Holsapple J, Heldt T. A Spectral Approach to Model-Based Noninvasive Intracranial Pressure Estimation. IEEE J Biomed Health Inform. 2020 Aug; 24(8):2398-2406. PMID: 31880569.
    Citations:    
  2. Filbin MR, Thorsen JE, Zachary TM, Lynch JC, Matsushima M, Belsky JB, Heldt T, Reisner AT. Antibiotic Delays and Feasibility of a 1-Hour-From-Triage Antibiotic Requirement: Analysis of an Emergency Department Sepsis Quality Improvement Database. Ann Emerg Med. 2020 01; 75(1):93-99. PMID: 31561998.
    Citations:    
  3. M Imaduddin S, Fanelli A, Vonberg FW, Tasker RC, Heldt T. Pseudo-Bayesian Model-Based Noninvasive Intracranial Pressure Estimation and Tracking. IEEE Trans Biomed Eng. 2020 Jun; 67(6):1604-1615. PMID: 31535978.
    Citations:    
  4. Fanelli A, Vonberg FW, LaRovere KL, Walsh BK, Smith ER, Robinson S, Tasker RC, Heldt T. Fully automated, real-time, calibration-free, continuous noninvasive estimation of intracranial pressure in children. J Neurosurg Pediatr. 2019 Aug 23; 1-11. PMID: 31443086.
    Citations:    
  5. Diaz-Artiles A, Heldt T, Young LR. Computational model of cardiovascular response to centrifugation and lower body cycling exercise. J Appl Physiol (1985). 2019 11 01; 127(5):1453-1468. PMID: 31343946.
    Citations:    
  6. Imaduddin SM, LaRovere KL, Kussman BD, Heldt T. A Time-Frequency Approach for Cerebral Embolic Load Monitoring. IEEE Trans Biomed Eng. 2020 Apr; 67(4):1007-1018. PMID: 31295101.
    Citations:    
  7. Prasad V, Lynch JC, Filbin MR, Reisner AT, Heldt T. Clustering Blood Pressure Trajectories in Septic Shock in the Emergency Department. Conf Proc IEEE Eng Med Biol Soc. 2019 07; 2019:494-497. PMID: 31945945.
    Citations:    
  8. Jaishankar R, Fanelli A, Filippidis A, Vu T, Holsapple J, Heldt T. A Frequency-domain Approach to Noninvasive Intracranial Pressure Estimation. Conf Proc IEEE Eng Med Biol Soc. 2019 07; 2019:5055-5058. PMID: 31946995.
    Citations:    
  9. Gu Q, Prasad V, Heldt T. Characterizing Fluid Response and Sepsis Progression in Emergency Department Patients. Conf Proc IEEE Eng Med Biol Soc. 2019 07; 2019:510-513. PMID: 31945949.
    Citations:    
  10. Heldt T, Zoerle T, Teichmann D, Stocchetti N. Intracranial Pressure and Intracranial Elastance Monitoring in Neurocritical Care. Annu Rev Biomed Eng. 2019 06 04; 21:523-549. PMID: 31167100.
    Citations:    
  11. Wadehn F, Weber T, Mack DJ, Heldt T, Loeliger HA. Model-Based Separation, Detection, and Classification of Eye Movements. IEEE Trans Biomed Eng. 2020 02; 67(2):588-600. PMID: 31150326.
    Citations:    
  12. Lai HY, Saavedra-Pena G, Sodini CG, Sze V, Heldt T. Measuring Saccade Latency Using Smartphone Cameras. IEEE J Biomed Health Inform. 2020 03; 24(3):885-897. PMID: 31056528.
    Citations:    
  13. Filbin MR, Heldt T, Reisner AT. The authors reply. Crit Care Med. 2018 12; 46(12):e1222-e1223. PMID: 30444821.
    Citations:    Fields:    
  14. Birjiniuk J, Heldt T. Tracking autonomic balance using an open-loop model of the arterial baroreflex. Am J Physiol Regul Integr Comp Physiol. 2019 02 01; 316(2):R121-R129. PMID: 30462526.
    Citations:    Fields:    
  15. Diaz-Artiles A, Heldt T, Young LR. Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise. Front Physiol. 2018; 9:1492. PMID: 30483141.
    Citations:    
  16. Jinadasa SP, Mueller A, Prasad V, Subramaniam K, Heldt T, Novack V, Subramaniam B. Blood Pressure Coefficient of Variation and Its Association With Cardiac Surgical Outcomes. Anesth Analg. 2018 10; 127(4):832-839. PMID: 29624524.
    Citations:    Fields:    
  17. Filbin MR, Lynch J, Gillingham TD, Thorsen JE, Pasakarnis CL, Nepal S, Matsushima M, Rhee C, Heldt T, Reisner AT. Presenting Symptoms Independently Predict Mortality in Septic Shock: Importance of a Previously Unmeasured Confounder. Crit Care Med. 2018 10; 46(10):1592-1599. PMID: 29965833.
    Citations: 2     Fields:    
  18. Li T, Matsushima M, Timpson W, Young S, Miedema D, Gupta M, Heldt T. Correction: Epidemiology of patient monitoring alarms in the neonatal intensive care unit. J Perinatol. 2018 Aug; 38(8):1124. PMID: 30046177.
    Citations:    Fields:    
  19. Filbin MR, Thorsen JE, Lynch J, Gillingham TD, Pasakarnis CL, Capp R, Shapiro NI, Mooncai T, Hou PC, Heldt T, Reisner AT. Challenges and Opportunities for Emergency Department Sepsis Screening at Triage. Sci Rep. 2018 07 23; 8(1):11059. PMID: 30038408.
    Citations:    Fields:    
  20. Shim EB, Heldt T. Fluid-structure Interaction in the Cerebral Venous Transverse Sinus. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:4544-4547. PMID: 30441362.
    Citations:    Fields:    
  21. Birjiniuk J, Gordhandas AJ, Verghese GC, Heldt T. A Fiducial Scaffold for ECG Compression in Low-Powered Devices. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:1-4. PMID: 30440279.
    Citations:    Fields:    
  22. Karasan E, Abid A, Mieloszyk RJ, Krauss BS, Heldt T, Verghese GC. An Enhanced Mechanistic Model For Capnography, With Application To CHF-COPD Discrimination. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:5267-5272. PMID: 30441526.
    Citations:    Fields:    
  23. Saavedra-Pena G, Lai HY, Sze V, Heldt T. Determination of Saccade Latency Distributions using Video Recordings from Consumer-grade Devices. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:953-956. PMID: 30440548.
    Citations:    Fields:    
  24. Li T, Matsushima M, Timpson W, Young S, Miedema D, Gupta M, Heldt T. Epidemiology of patient monitoring alarms in the neonatal intensive care unit. J Perinatol. 2018 08; 38(8):1030-1038. PMID: 29740183.
    Citations:    Fields:    
  25. Fanelli A, Jaishankar R, Filippidis A, Holsapple J, Heldt T. A Waveform Archiving System for the GE Solar 8000i Bedside Monitor. Acta Neurochir Suppl. 2018; 126:173-177. PMID: 29492556.
    Citations:    Fields:    Translation:Humans
  26. Matthews JM, Fanelli A, Heldt T. An Embedded Device for Real-Time Noninvasive Intracranial Pressure Estimation. Acta Neurochir Suppl. 2018; 126:85-88. PMID: 29492538.
    Citations:    Fields:    Translation:Humans
  27. Prasad V, Guerrisi M, Dauri M, Coniglione F, Tisone G, De Carolis E, Cillis A, Canichella A, Toschi N, Heldt T. Prediction of postoperative outcomes using intraoperative hemodynamic monitoring data. Sci Rep. 2017 11 27; 7(1):16376. PMID: 29180647.
    Citations:    Fields:    
  28. Fanelli A, Vonberg FW, Jaishankar R, Imaduddin SM, Tasker RC, Heldt T. Regression-based noninvasive estimation of intracranial pressure. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:4001-4004. PMID: 29060774.
    Citations:    Fields:    Translation:Humans
  29. Imaduddin SM, Heldt T. Model-based estimation of radial artery blood pressure from recordings of the Nexfin monitor. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:1692-1695. PMID: 29060211.
    Citations:    Fields:    Translation:Humans
  30. Prasad V, Lynch JC, Pasakarnis CL, Thorsen JE, Filbin MR, Reisner AT, Heldt T. Classification models to predict vasopressor administration for septic shock in the emergency department. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:2650-2653. PMID: 29060444.
    Citations:    Fields:    Translation:Humans
  31. Mieloszyk RJ, Krauss BS, Montagu D, Andolfatto G, Barbi E, Verghese GC, Heldt T. Statistical analysis of the age dependence of the normal capnogram. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:345-348. PMID: 29059881.
    Citations:    Fields:    Translation:Humans
  32. Dekimpe R, Heldt T. Reducing false asystole alarms in intensive care. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:2292-2295. PMID: 29060355.
    Citations:    Fields:    Translation:Humans
  33. Abid A, Mieloszyk RJ, Verghese GC, Krauss BS, Heldt T. Model-Based Estimation of Respiratory Parameters from Capnography, With Application to Diagnosing Obstructive Lung Disease. IEEE Trans Biomed Eng. 2017 12; 64(12):2957-2967. PMID: 28475040.
    Citations:    Fields:    Translation:Humans
  34. Noraky J, Verghese GC, Searls DE, Lioutas VA, Sonni S, Thomas A, Heldt T. Noninvasive Intracranial Pressure Determination in Patients with Subarachnoid Hemorrhage. Acta Neurochir Suppl. 2016; 122:65-8. PMID: 27165879.
    Citations:    Fields:    Translation:Humans
  35. Dunitz M, Verghese G, Heldt T. Predicting hyperlactatemia in the MIMIC II database. Conf Proc IEEE Eng Med Biol Soc. 2015 08; 2015:985-8. PMID: 26736429.
    Citations: 1     Fields:    Translation:Humans
  36. Mieloszyk RJ, Guo MG, Verghese GC, Andolfatto G, Heldt T, Krauss BS. Clustering of capnogram features to track state transitions during procedural sedation. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:1699-702. PMID: 26736604.
    Citations: 1     Fields:    Translation:Humans
  37. Prasad V, Toschi N, Canichella A, Marcellucci M, Coniglione F, Dauri M, Guerrisi M, Heldt T. Intraoperative hemodynamics predict postoperative mortality in orthotopic liver transplantation. Conf Proc IEEE Eng Med Biol Soc. 2015 08; 2015:989-92. PMID: 26736430.
    Citations:    Fields:    Translation:Humans
  38. Abid A, Mieloszyk RJ, Verghese GC, Krauss BS, Heldt T. Model-based estimation of pulmonary compliance and resistance parameters from time-based capnography. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:1687-90. PMID: 26736601.
    Citations:    Fields:    Translation:Humans
  39. Mieloszyk RJ, Verghese GC, Deitch K, Cooney B, Khalid A, Mirre-Gonzalez MA, Heldt T, Krauss BS. Automated quantitative analysis of capnogram shape for COPD-normal and COPD-CHF classification. IEEE Trans Biomed Eng. 2014 Dec; 61(12):2882-90. PMID: 24967981.
    Citations: 1     Fields:    Translation:Humans
  40. Subramaniam B, Khabbaz KR, Heldt T, Lerner AB, Mittleman MA, Davis RB, Goldberger AL, Costa MD. Blood pressure variability: can nonlinear dynamics enhance risk assessment during cardiovascular surgery? J Cardiothorac Vasc Anesth. 2014 Apr; 28(2):392-7. PMID: 24508020.
    Citations: 4     Fields:    Translation:Humans
  41. Ranger M, Celeste Johnston C, Rennick JE, Limperopoulos C, Heldt T, du Plessis AJ. A multidimensional approach to pain assessment in critically ill infants during a painful procedure. Clin J Pain. 2013 Jul; 29(7):613-20. PMID: 23328334.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  42. Reisner AT, Heldt T. A computational model of hemorrhage and dehydration suggests a pathophysiological mechanism: Starling-mediated protein trapping. Am J Physiol Heart Circ Physiol. 2013 Feb 15; 304(4):H620-31. PMID: 23203962.
    Citations:    Fields:    Translation:HumansAnimals
  43. Shim EB, Heldt T, Amano A, Rhee K. Computational analysis of cardiovascular hemodynamics. Comput Math Methods Med. 2012; 2012:260396. PMID: 22991576.
    Citations:    Fields:    Translation:Humans
  44. Kashif FM, Verghese GC, Novak V, Czosnyka M, Heldt T. Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial pressure. Sci Transl Med. 2012 Apr 11; 4(129):129ra44. PMID: 22496546.
    Citations: 14     Fields:    Translation:Humans
  45. Heldt T, Kashif FM, Sulemanji M, O'Leary HM, du Plessis AJ, Verghese GC. Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings. Acta Neurochir Suppl. 2012; 114:177-80. PMID: 22327688.
    Citations: 2     Fields:    Translation:Humans
  46. Saeed M, Villarroel M, Reisner AT, Clifford G, Lehman LW, Moody G, Heldt T, Kyaw TH, Moody B, Mark RG. Multiparameter Intelligent Monitoring in Intensive Care II: a public-access intensive care unit database. Crit Care Med. 2011 May; 39(5):952-60. PMID: 21283005.
    Citations: 144     Fields:    Translation:Humans
  47. Haslam B, Gordhandas A, Ricciardi C, Verghese G, Heldt T. Distilling clinically interpretable information from data collected on next-generation wearable sensors. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1729-32. PMID: 22254660.
    Citations:    Fields:    Translation:Humans
  48. He DD, Winokur ES, Heldt T, Sodini CG. The ear as a location for wearable vital signs monitoring. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:6389-92. PMID: 21096700.
    Citations: 3     Fields:    Translation:Humans
  49. Heldt T, Verghese GC. Model-based data integration in clinical environments. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:5209-12. PMID: 21095826.
    Citations: 1     Fields:    Translation:Humans
  50. Heldt T, Mukkamala R, Moody GB, Mark RG. CVSim: An Open-Source Cardiovascular Simulator for Teaching and Research. Open Pacing Electrophysiol Ther J. 2010; 3:45-54. PMID: 21949555.
    Citations:    
  51. Sun JX, Reisner AT, Saeed M, Heldt T, Mark RG. The cardiac output from blood pressure algorithms trial. Crit Care Med. 2009 Jan; 37(1):72-80. PMID: 19112280.
    Citations: 12     Fields:    Translation:Humans
  52. Heldt T. Continuous blood pressure-derived cardiac output monitoring--should we be thinking long term? J Appl Physiol (1985). 2006 Aug; 101(2):373-4. PMID: 16690788.
    Citations: 4     Fields:    Translation:Humans
  53. Roberts JM, Parlikar TA, Heldt T, Verghese GC. Bayesian networks for cardiovascular monitoring. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:205-9. PMID: 17946804.
    Citations:    Fields:    Translation:Humans
  54. Heldt T, Long B, Verghese GC, Szolovits P, Mark RG. Integrating data, models, and reasoning in critical care. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:350-3. PMID: 17946818.
    Citations: 3     Fields:    Translation:Humans
  55. Heldt T, Chang JL, Chen JJ, Verghese GC, Mark RG. Cycle-averaged dynamics of a periodically driven, closed-loop circulation model. Control Eng Pract. 2005 Sep; 13(9):1163-71. PMID: 16050064.
    Citations: 2     
  56. Heldt T, Shim EB, Kamm RD, Mark RG. Computational modeling of cardiovascular response to orthostatic stress. J Appl Physiol (1985). 2002 Mar; 92(3):1239-54. PMID: 11842064.
    Citations: 29     Fields:    Translation:Humans
  57. Heldt T, Shim EB, Kamm RD, Mark RG. Model-based parameter estimation using cardiovascular response to orthostatic stress. Comput Cardiol. 2001; 28:337-40. PMID: 14640093.
    Citations:    Translation:Humans
  58. Heldt T, Shim EB, Kamm RD, Mark RG. Computational model of cardiovascular function during orthostatic stress. Comput Cardiol. 2000; 27:777-80. PMID: 11806418.
    Citations: 1     Translation:Humans
  59. Shim EB, Kamm RD, Heldt T, Mark RG. Numerical analysis of blood flow through a stenosed artery using a coupled, multiscale simulation method. Comput Cardiol. 2000; 27:219-22. PMID: 12085933.
    Citations: 2     Translation:Humans
  60. Heldt T, Shim EB, Kamm RD, Mark RG. Computational models of cardiovascular function for analysis of post-flight orthostatic intolerance. Comput Cardiol. 1999; 26:213-6. PMID: 11795340.
    Citations:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.