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Oluwaseun Johnson-Akeju, M.D.

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Overview

Research
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  1. R01AG053582 (JOHNSON-AKEJU, OLUWASEUN) Sep 1, 2016 - May 31, 2021
    NIH
    Pathophysiology of postoperative delirium and the use of biomimetic sleep as a treatment strategy in the CSICU
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ulsa MC, Xi Z, Li P, Gaba A, Wong PM, Saxena R, Scheer FAJL, Rutter M, Akeju O, Hu K, Gao L. Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization. J Gerontol A Biol Sci Med Sci. 2022 Mar 03; 77(3):507-516. PMID: 34558609.
    Citations: 1     Fields:    
  2. Brusaferri L, Alshelh Z, Martins D, Kim M, Weerasekera A, Housman H, Morrissey EJ, Knight PC, Castro-Blanco KA, Albrecht DS, Tseng CE, Zürcher NR, Ratai EM, Akeju O, Makary MM, Catana C, Mercaldo ND, Hadjikhani N, Veronese M, Turkheimer F, Rosen BR, Hooker JM, Loggia ML. The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic. Brain Behav Immun. 2022 May; 102:89-97. PMID: 35181440.
    Citations:    Fields:    
  3. Sari H, Galbusera R, Bonnier G, Lin Y, Alshelh Z, Torrado-Carvajal A, Mukerji SS, Ratai EM, Gandhi RT, Chu JT, Akeju O, Orhurhu V, Salvatore AN, Sherman J, Kwon DS, Walker B, Rosen B, Price JC, Pollak LE, Loggia M, Granziera C. Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers. Neurol Neuroimmunol Neuroinflamm. 2022 03; 9(2). PMID: 35140142.
    Citations: 1     Fields:    
  4. Maher SS, Franco-Garcia E, Zhou C, Heng M, van Pelt M, Akeju O, Quraishi SA. Association of Nutritional Status with New-Onset Delirium in Elderly, Acute Care, Orthopaedic Trauma Patients: A Single-Center Observational Study. J Orthop Trauma. 2022 Feb 01; 36(2):67-72. PMID: 35061654.
    Citations:    Fields:    Translation:Humans
  5. Tesh RA, Sun H, Jing J, Westmeijer M, Neelagiri A, Rajan S, Krishnamurthy PV, Sikka P, Quadri SA, Leone MJ, Paixao L, Panneerselvam E, Eckhardt C, Struck AF, Kaplan PW, Akeju O, Jones D, Kimchi EY, Westover MB. VE-CAM-S: Visual EEG-Based Grading of Delirium Severity and Associations With Clinical Outcomes. Crit Care Explor. 2022 Jan; 4(1):e0611. PMID: 35072078.
    Citations:    
  6. van Sleuwen M, Sun H, Eckhardt C, Neelagiri A, Tesh RA, Westmeijer M, Paixao L, Rajan S, Velpula Krishnamurthy P, Sikka P, Leone MJ, Panneerselvam E, Quadri SA, Akeju O, Kimchi EY, Westover MB. Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S). Crit Care Med. 2022 01 01; 50(1):e11-e19. PMID: 34582420.
    Citations: 1     Fields:    Translation:Humans
  7. Gao L, Gaba A, Li P, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Hu K. Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults. J Sport Health Sci. 2021 Dec 13. PMID: 34915199.
    Citations:    Fields:    
  8. Paixao L, Sun H, Hogan J, Hartnack K, Westmeijer M, Neelagiri A, Zhou DW, McClain LM, Kimchi EY, Purdon PL, Akeju O, Westover MB. ICU delirium burden predicts functional neurologic outcomes. PLoS One. 2021; 16(12):e0259840. PMID: 34855749.
    Citations:    Fields:    Translation:Humans
  9. Chamadia S, Gitlin J, Mekonnen J, Ethridge BR, Ibala R, Colon KM, Qu J, Akeju O. Ketamine induces EEG oscillations that may aid anesthetic state but not dissociation monitoring. Clin Neurophysiol. 2021 12; 132(12):3010-3018. PMID: 34715426.
    Citations: 1     Fields:    Translation:Humans
  10. Alshelh Z, Brusaferri L, Saha A, Morrissey E, Knight P, Kim M, Zhang Y, Hooker JM, Albrecht D, Torrado-Carvajal A, Placzek MS, Akeju O, Price J, Edwards RR, Lee J, Sclocco R, Catana C, Napadow V, Loggia ML. Neuro-immune signatures in chronic low back pain subtypes. Brain. 2021 Sep 16. PMID: 34528069.
    Citations:    Fields:    
  11. Esmaeeli S, Franco-Garcia E, Akeju O, Heng M, Zhou C, Azocar RJ, Quraishi SA. Association of preoperative frailty with postoperative delirium in elderly orthopedic trauma patients. Aging Clin Exp Res. 2022 Mar; 34(3):625-631. PMID: 34417994.
    Citations: 1     Fields:    Translation:Humans
  12. Ganglberger W, Bucklin AA, Tesh RA, Da Silva Cardoso M, Sun H, Leone MJ, Paixao L, Panneerselvam E, Ye EM, Thompson BT, Akeju O, Kuller D, Thomas RJ, Westover MB. Sleep apnea and respiratory anomaly detection from a wearable band and oxygen saturation. Sleep Breath. 2021 Aug 18. PMID: 34409545.
    Citations:    Fields:    
  13. Garwood IC, Chakravarty S, Donoghue J, Mahnke M, Kahali P, Chamadia S, Akeju O, Miller EK, Brown EN. A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms. PLoS Comput Biol. 2021 08; 17(8):e1009280. PMID: 34407069.
    Citations: 1     Fields:    Translation:HumansAnimals
  14. Safaee Fakhr B, Di Fenza R, Gianni S, Wiegand SB, Miyazaki Y, Araujo Morais CC, Gibson LE, Chang MG, Mueller AL, Rodriguez-Lopez JM, Ackman JB, Arora P, Scott LK, Bloch DB, Zapol WM, Carroll RW, Ichinose F, Berra L. Inhaled high dose nitric oxide is a safe and effective respiratory treatment in spontaneous breathing hospitalized patients with COVID-19 pneumonia. Nitric Oxide. 2021 11 01; 116:7-13. PMID: 34400339.
    Citations: 4     Fields:    Translation:Humans
  15. Rhee J, Kuznetsov A, McKay T, Lyons M, Houstis N, Mekkonen J, Ethridge B, Ibala R, Hahm E, Gitlin J, Guseh JS, Kitchen R, Rosenzweig A, Shaefi S, Flaczyk A, Qu J, Akeju O. Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium. Front Aging Neurosci. 2021; 13:699763. PMID: 34456709.
    Citations:    
  16. Weerasekera A, Morrissey E, Kim M, Saha A, Lin Y, Alshelh Z, Torrado-Carvajal A, Albrecht D, Akeju O, Kwon YM, Bedair H, Chen AF, Napadow V, Schreiber K, Ratai EM, Edwards RR, Loggia ML. Thalamic neurometabolite alterations in patients with knee osteoarthritis before and after total knee replacement. Pain. 2021 07 01; 162(7):2014-2023. PMID: 33470749.
    Citations: 4     Fields:    Translation:Humans
  17. Hahm EY, Chamadia S, Locascio JJ, Pedemonte JC, Gitlin J, Mekonnen J, Ibala R, Ethridge BR, Colon KM, Qu J, Akeju O. Dissociative and analgesic properties of ketamine are independent and unaltered by sevoflurane general anesthesia. Pain Rep. 2021 Jul-Aug; 6(2):e936. PMID: 34104842.
    Citations:    
  18. Pedemonte JC, Sun H, Franco-Garcia E, Zhou C, Heng M, Quraishi SA, Westover B, Akeju O. Postoperative delirium mediates 180-day mortality in orthopaedic trauma patients. Br J Anaesth. 2021 07; 127(1):102-109. PMID: 34074525.
    Citations:    Fields:    Translation:Humans
  19. Kato R, Zhang ER, Mallari OG, Moody OA, Vincent KF, Melonakos ED, Siegmann MJ, Nehs CJ, Houle TT, Akeju O, Solt K. D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats. Front Pharmacol. 2021; 12:668285. PMID: 34084141.
    Citations: 2     
  20. McKay TB, Rhee J, Colon K, Adelsberger K, Turco I, Mueller A, Qu J, Akeju O. Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 01; 36(1):118-124. PMID: 34112563.
    Citations:    Fields:    Translation:Humans
  21. Rong A, Franco-Garcia E, Zhou C, Heng M, Akeju O, Azocar RJ, Quraishi SA. Association of nutrition status and hospital-acquired infections in older adult orthopedic trauma patients. JPEN J Parenter Enteral Nutr. 2022 01; 46(1):69-74. PMID: 33660849.
    Citations:    Fields:    
  22. Torrado-Carvajal A, Toschi N, Albrecht DS, Chang K, Akeju O, Kim M, Edwards RR, Zhang Y, Hooker JM, Duggento A, Kalpathy-Cramer J, Napadow V, Loggia ML. Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain. Pain. 2021 04 01; 162(4):1241-1249. PMID: 33065737.
    Citations: 7     Fields:    Translation:Humans
  23. Ibala R, Mekonnen J, Gitlin J, Hahm EY, Ethridge BR, Colon KM, Marota S, Ortega C, Pedemonte JC, Cobanaj M, Chamadia S, Qu J, Gao L, Barbieri R, Akeju O. A polysomnography study examining the association between sleep and postoperative delirium in older hospitalized cardiac surgical patients. J Sleep Res. 2021 10; 30(5):e13322. PMID: 33759264.
    Citations: 1     Fields:    Translation:Humans
  24. Pedemonte JC, Locascio JJ, Houle T, Akeju O. Burst-suppression and Postoperative Delirium: Reply. Anesthesiology. 2021 02 01; 134(2):352-353. PMID: 33433617.
    Citations:    Fields:    Translation:Humans
  25. Kim MC, Fricchione GL, Akeju O. Accidental awareness under general anaesthesia: Incidence, risk factors, and psychological management. BJA Educ. 2021 Apr; 21(4):154-161. PMID: 33777414.
    Citations: 1     
  26. Gao L, Gaba A, Cui L, Yang HW, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Lo MT, Hu K, Li P. Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank. J Am Heart Assoc. 2021 02 02; 10(3):e018483. PMID: 33461311.
    Citations: 2     Fields:    Translation:Humans
  27. Rao RC, Dlouhy BJ, Capell BC, Akeju O. The endangered physician-scientist and COVID-19. Cell Rep Med. 2021 02 16; 2(2):100190. PMID: 33521693.
    Citations: 1     Fields:    Translation:HumansCells
  28. Sydnor VJ, Lyall AE, Cetin-Karayumak S, Cheung JC, Felicione JM, Akeju O, Shenton ME, Deckersbach T, Ionescu DF, Pasternak O, Cusin C, Kubicki M. Studying pre-treatment and ketamine-induced changes in white matter microstructure in the context of ketamine's antidepressant effects. Transl Psychiatry. 2020 12 15; 10(1):432. PMID: 33319774.
    Citations: 1     Fields:    Translation:Humans
  29. Chamadia S, Pedemonte JC, Hobbs LE, Deng H, Nguyen S, Cortinez LI, Akeju O. A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine. Anesthesiology. 2020 12 01; 133(6):1223-1233. PMID: 32986820.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  30. Chamadia S, Hobbs L, Marota S, Ibala R, Hahm E, Gitlin J, Mekonnen J, Ethridge B, Colon KM, Sheppard KS, Manoach DS, DiBiasio A, Nguyen S, Pedemonte JC, Akeju O. Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans. Anesthesiology. 2020 12 01; 133(6):1234-1243. PMID: 33001139.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  31. Gitlin J, Chamadia S, Locascio JJ, Ethridge BR, Pedemonte JC, Hahm EY, Ibala R, Mekonnen J, Colon KM, Qu J, Akeju O. Dissociative and Analgesic Properties of Ketamine Are Independent. Anesthesiology. 2020 11 01; 133(5):1021-1028. PMID: 32898213.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  32. Hogan J, Sun H, Paixao L, Westmeijer M, Sikka P, Jin J, Tesh R, Cardoso M, Cash SS, Akeju O, Thomas R, Westover MB. Night-to-night variability of sleep electroencephalography-based brain age measurements. Clin Neurophysiol. 2021 01; 132(1):1-12. PMID: 33248430.
    Citations: 1     Fields:    Translation:Humans
  33. Althoff FC, Wachtendorf LJ, Rostin P, Santer P, Schaefer MS, Xu X, Grabitz SD, Chitilian H, Houle TT, Brat GA, Akeju O, Eikermann M. Effects of night surgery on postoperative mortality and morbidity: a multicentre cohort study. BMJ Qual Saf. 2021 08; 30(8):678-688. PMID: 33028658.
    Citations: 5     Fields:    Translation:Humans
  34. Solt K, Akeju O. The brain rhythms that detach us from reality. Nature. 2020 10; 586(7827):31-32. PMID: 32939081.
    Citations: 1     Fields:    Translation:Humans
  35. Hogan J, Sun H, Aboul Nour H, Jing J, Tabaeizadeh M, Shoukat M, Javed F, Kassa S, Edhi MM, Bordbar E, Gallagher J, Junior VM, Ghanta M, Shao YP, Akeju O, Cole AJ, Rosenthal ES, Zafar S, Westover MB. Burst Suppression: Causes and Effects on Mortality in Critical Illness. Neurocrit Care. 2020 10; 33(2):565-574. PMID: 32096120.
    Citations: 3     Fields:    Translation:Humans
  36. Osho AA, Moonsamy P, Ethridge BR, Leya GA, D'Alessandro DA, Jassar AS, Villavicencio MA, Melnitchouk SI, Tolis G, Langer NB, Funamoto M, Li SS, Colon KM, Mohan N, Locascio JJ, Lubitz SA, Akeju O, Sundt TM. Rationale and Design of the Randomized Controlled Trial of New Oral Anticoagulants vs. Warfarin for post Cardiac Surgery Atrial Fibrillation: The NEW-AF Trial. Ann Surg. 2020 Sep 01. PMID: 32889881.
    Citations:    Fields:    
  37. Kashkooli K, Polk SL, Hahm EY, Murphy J, Ethridge BR, Gitlin J, Ibala R, Mekonnen J, Pedemonte JC, Sun H, Westover MB, Barbieri R, Akeju O, Chamadia S. Improved tracking of sevoflurane anesthetic states with drug-specific machine learning models. J Neural Eng. 2020 08 04; 17(4):046020. PMID: 32485685.
    Citations: 1     Fields:    
  38. Pedemonte JC, Plummer GS, Chamadia S, Locascio JJ, Hahm E, Ethridge B, Gitlin J, Ibala R, Mekonnen J, Colon KM, Westover MB, D'Alessandro DA, Tolis G, Houle T, Shelton KT, Qu J, Akeju O. Electroencephalogram Burst-suppression during Cardiopulmonary Bypass in Elderly Patients Mediates Postoperative Delirium. Anesthesiology. 2020 08; 133(2):280-292. PMID: 32349072.
    Citations: 7     Fields:    Translation:Humans
  39. Albutt K, Luckhurst CM, Alba GA, Hechi ME, Mokhtari A, Breen K, Wing J, Akeju O, Kalva SP, Mullen JT, Lillemoe KD, Kaafarani H. Design and Impact of a COVID-19 Multidisciplinary Bundled Procedure Team. Ann Surg. 2020 08; 272(2):e72-e73. PMID: 32675501.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  40. Sun H, Ganglberger W, Panneerselvam E, Leone MJ, Quadri SA, Goparaju B, Tesh RA, Akeju O, Thomas RJ, Westover MB. Sleep staging from electrocardiography and respiration with deep learning. Sleep. 2020 07 13; 43(7). PMID: 31863111.
    Citations: 13     Fields:    
  41. Conti A, Akeju O, Duggento A, Chamadia S, Barbieri R, Toschi N. Frequency dependent functional brain reorganization in anesthesia is specific to drug concentration. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:2921-2924. PMID: 33018618.
    Citations:    Fields:    Translation:Humans
  42. Kim MC, Fricchione GL, Brown EN, Akeju O. Corrigendum to 'Role of electroencephalogram oscillations and the spectrogram in monitoring anaesthesia' [BJA Education 20 (2020) 166-172]. BJA Educ. 2020 Jul; 20(7):249. PMID: 33465181.
    Citations:    
  43. Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA. Extra-Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura. Ann Neurol. 2020 06; 87(6):939-949. PMID: 32239542.
    Citations: 6     Fields:    Translation:Humans
  44. Oh ES, Akeju O, Avidan MS, Cunningham C, Hayden KM, Jones RN, Khachaturian AS, Khan BA, Marcantonio ER, Needham DM, Neufeld KJ, Rose L, Spence J, Tieges Z, Vlisides P, Inouye SK. A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank. Alzheimers Dement. 2020 05; 16(5):726-733. PMID: 32291901.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  45. Thevathasan T, Grabitz SD, Santer P, Rostin P, Akeju O, Boghosian JD, Gill M, Isaacs L, Cotten JF, Eikermann M. Calabadion 1 selectively reverses respiratory and central nervous system effects of fentanyl in a rat model. Br J Anaesth. 2020 07; 125(1):e140-e147. PMID: 32241547.
    Citations: 5     Fields:    Translation:Animals
  46. Eikermann M, Akeju O, Chamberlin NL. Sleep and Anesthesia: The Shared Circuit Hypothesis Has Been Put to Bed. Curr Biol. 2020 03 09; 30(5):R219-R221. PMID: 32155424.
    Citations: 3     Fields:    Translation:Cells
  47. Kim MC, Fricchione GL, Brown EN, Akeju O. Role of electroencephalogram oscillations and the spectrogram in monitoring anaesthesia. BJA Educ. 2020 May; 20(5):166-172. PMID: 33456946.
    Citations: 1     
  48. Alshelh Z, Albrecht DS, Bergan C, Akeju O, Clauw DJ, Conboy L, Edwards RR, Kim M, Lee YC, Protsenko E, Napadow V, Sullivan K, Loggia ML. In-vivo imaging of neuroinflammation in veterans with Gulf War illness. Brain Behav Immun. 2020 07; 87:498-507. PMID: 32027960.
    Citations: 29     Fields:    Translation:HumansCells
  49. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019; 2:415. PMID: 31754645.
    Citations: 9     Translation:HumansCells
  50. Zheng WL, Sun H, Akeju O, Westover MB. Adaptive Sedation Monitoring From EEG in ICU Patients With Online Learning. IEEE Trans Biomed Eng. 2020 06; 67(6):1696-1706. PMID: 31545708.
    Citations:    Fields:    Translation:Humans
  51. Sun H, Kimchi E, Akeju O, Nagaraj SB, McClain LM, Zhou DW, Boyle E, Zheng WL, Ge W, Westover MB. Automated tracking of level of consciousness and delirium in critical illness using deep learning. NPJ Digit Med. 2019; 2:89. PMID: 31508499.
    Citations: 7     
  52. Kashkooli K, Polk SL, Chamadia S, Hahm E, Ethridge B, Gitlin J, Ibala R, Mekonnen J, Pedemonte J, Murphy JM, Sun H, Westover MB, Akeju O. Drug-Specific Models Improve the Performance of an EEG-based Automated Brain-State Prediction System. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:5808-5811. PMID: 31947172.
    Citations: 1     Fields:    Translation:Humans
  53. Polk SL, Kashkooli K, Nagaraj SB, Chamadia S, Murphy JM, Sun H, Westover MB, Barbieri R, Akeju O. Automatic Detection of General Anesthetic-States using ECG-Derived Autonomic Nervous System Features. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:2019-2022. PMID: 31946297.
    Citations: 1     Fields:    Translation:Humans
  54. Fadayomi AB, Johnson-Akeju O. The authors reply. Crit Care Med. 2019 06; 47(6):e530-e531. PMID: 31095026.
    Citations:    Fields:    Translation:Humans
  55. Albrecht DS, Kim M, Akeju O, Torrado-Carvajal A, Edwards RR, Zhang Y, Bergan C, Protsenko E, Kucyi A, Wasan AD, Hooker JM, Napadow V, Loggia ML. The neuroinflammatory component of negative affect in patients with chronic pain. Mol Psychiatry. 2021 03; 26(3):864-874. PMID: 31138890.
    Citations: 17     Fields:    Translation:HumansCells
  56. Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Loggia ML, Hadjikhani N. Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study. Neurology. 2019 04 23; 92(17):e2038-e2050. PMID: 30918090.
    Citations: 20     Fields:    Translation:Humans
  57. Nozari A, Akeju O, Mirzakhani H, Eskandar E, Ma Z, Hossain MA, Wang Q, Greenblatt DJ, Martyn JAJ. Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl. J Pharm Pharmacol. 2019 Jun; 71(6):982-987. PMID: 30793320.
    Citations: 2     Fields:    Translation:Humans
  58. Fadayomi AB, Ibala R, Bilotta F, Westover MB, Akeju O. A Systematic Review and Meta-Analysis Examining the Impact of Sleep Disturbance on Postoperative Delirium. Crit Care Med. 2018 12; 46(12):e1204-e1212. PMID: 30222634.
    Citations: 20     Fields:    Translation:Humans
  59. Plummer GS, Ibala R, Hahm E, An J, Gitlin J, Deng H, Shelton KT, Solt K, Qu JZ, Akeju O. Electroencephalogram dynamics during general anesthesia predict the later incidence and duration of burst-suppression during cardiopulmonary bypass. Clin Neurophysiol. 2019 01; 130(1):55-60. PMID: 30476711.
    Citations: 5     Fields:    Translation:Humans
  60. Sun H, Paixao L, Oliva JT, Goparaju B, Carvalho DZ, van Leeuwen KG, Akeju O, Thomas RJ, Cash SS, Bianchi MT, Westover MB. Brain age from the electroencephalogram of sleep. Neurobiol Aging. 2019 02; 74:112-120. PMID: 30448611.
    Citations: 15     Fields:    Translation:Humans
  61. Fadayomi AB, Akeju O. Anesthesia for stroke rescue. Curr Opin Anaesthesiol. 2018 Oct; 31(5):544-548. PMID: 30020156.
    Citations:    Fields:    Translation:Humans
  62. Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C. Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial. J Affect Disord. 2019 01 15; 243:516-524. PMID: 30286416.
    Citations: 34     Fields:    Translation:Humans
  63. Albrecht DS, Forsberg A, Sandström A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, Taylor N, Kim M, Hooker JM, Edwards RR, Napadow V, Kosek E, Loggia ML. Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation. Brain Behav Immun. 2019 01; 75:72-83. PMID: 30223011.
    Citations: 59     Fields:    Translation:HumansCells
  64. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    Citations: 8     Fields:    Translation:Humans
  65. Sun H, Nagaraj SB, Akeju O, Purdon PL, Westover BM. Brain Monitoring of Sedation in the Intensive Care Unit Using a Recurrent Neural Network. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1-4. PMID: 30440304.
    Citations: 3     Fields:    Translation:Humans
  66. Gritti P, Akeju O, Lorini FL, Lanterna LA, Brembilla C, Bilotta F. A Narrative Review of Adherence to Subarachnoid Hemorrhage Guidelines. J Neurosurg Anesthesiol. 2018 Jul; 30(3):203-216. PMID: 28816882.
    Citations: 2     Fields:    Translation:Humans
  67. Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O. Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial. BMJ Open. 2018 04 20; 8(4):e020316. PMID: 29678977.
    Citations: 13     Fields:    Translation:Humans
  68. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 07; 121(1):325-327. PMID: 29935587.
    Citations: 4     Fields:    
  69. Nagaraj SB, McClain LM, Boyle EJ, Zhou DW, Ramaswamy SM, Biswal S, Akeju O, Purdon PL, Westover MB. Electroencephalogram Based Detection of Deep Sedation in ICU Patients Using Atomic Decomposition. IEEE Trans Biomed Eng. 2018 12; 65(12):2684-2691. PMID: 29993386.
    Citations: 3     Fields:    Translation:Humans
  70. Gritti P, Akeju O, Lorini FL, Lanterna A, Brembilla C, Bilotta F. Breaking the rules: is it the neurointensivists' turn? Crit Care. 2018 01 29; 22(1):21. PMID: 29378635.
    Citations:    Fields:    Translation:Humans
  71. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN. Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Clin Neurophysiol. 2018 01; 129(1):69-78. PMID: 29154132.
    Citations: 23     Fields:    Translation:Humans
  72. Lewis LD, Akeju O. Hierarchy in disruption of large-scale networks across altered arousal states. Br J Anaesth. 2017 10 01; 119(4):566-568. PMID: 29121309.
    Citations: 1     Fields:    
  73. Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC. Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity. Br J Anaesth. 2017 09 01; 119(3):443-447. PMID: 28969326.
    Citations: 10     Fields:    Translation:HumansAnimals
  74. Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zürcher NR, Barth VN, Guehl NJ, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts. J Nucl Med. 2018 01; 59(1):107-114. PMID: 28818984.
    Citations: 14     Fields:    Translation:HumansCells
  75. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 08; 127(2):293-306. PMID: 28657957.
    Citations: 19     Fields:    Translation:Humans
  76. Nagaraj SB, Biswal S, Boyle EJ, Zhou DW, McClain LM, Bajwa EK, Quraishi SA, Akeju O, Barbieri R, Purdon PL, Westover MB. Patient-Specific Classification of ICU Sedation Levels From Heart Rate Variability. Crit Care Med. 2017 Jul; 45(7):e683-e690. PMID: 28441231.
    Citations: 11     Fields:    Translation:Humans
  77. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci. 2017 07 19; 37(29):6938-6945. PMID: 28626012.
    Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
  78. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    Citations: 16     
  79. Akeju O, Brown EN. Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep. Curr Opin Neurobiol. 2017 06; 44:178-185. PMID: 28544930.
    Citations: 49     Fields:    Translation:HumansCells
  80. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    Citations: 23     Fields:    Translation:Humans
  81. Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M. Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation. Aust N Z J Psychiatry. 2017 Jan; 51(1):55-64. PMID: 26893373.
    Citations: 22     Fields:    Translation:Humans
  82. Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Chonde DB, Izquierdo Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis. Neurology. 2016 Dec 13; 87(24):2554-2561. PMID: 27837005.
    Citations: 39     Fields:    Translation:HumansCells
  83. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    Citations: 30     Fields:    Translation:HumansCTClinical Trials
  84. Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 06; 77(6):e719-25. PMID: 27232360.
    Citations: 33     Fields:    Translation:Humans
  85. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861.
    Citations: 45     Fields:    Translation:Humans
  86. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81. PMID: 27178867.
    Citations: 21     Fields:    Translation:Humans
  87. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8. PMID: 26284863.
    Citations: 2     Fields:    Translation:Humans
  88. Akeju O, Pavone KJ, Thum JA, Firth PG, Westover MB, Puglia M, Shank ES, Brown EN, Purdon PL. Age-dependency of sevoflurane-induced electroencephalogram dynamics in children. Br J Anaesth. 2015 Jul; 115 Suppl 1:i66-i76. PMID: 26174303.
    Citations: 26     Fields:    Translation:Humans
  89. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57. PMID: 26174300.
    Citations: 84     Fields:    Translation:Humans
  90. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564. PMID: 26118489.
    Citations: 21     Fields:    Translation:Humans
  91. Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage Clin. 2015; 7:409-14. PMID: 25685708.
    Citations: 89     Fields:    Translation:HumansCells
  92. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914. PMID: 25649968.
    Citations: 11     Fields:    Translation:Humans
  93. Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, Rosen BR, Napadow V, Hooker JM. Evidence for brain glial activation in chronic pain patients. Brain. 2015 Mar; 138(Pt 3):604-15. PMID: 25582579.
    Citations: 156     Fields:    Translation:HumansCells
  94. Zhou DW, Westover MB, McClain LM, Nagaraj SB, Bajwa EK, Quraishi SA, Akeju O, Cobb JP, Purdon PL. Clustering analysis to identify distinct spectral components of encephalogram burst suppression in critically ill patients. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:7258-61. PMID: 26737967.
    Citations:    Fields:    Translation:Humans
  95. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022.
    Citations: 59     Fields:    Translation:Humans
  96. Valenza G, Akeju O, Pavone KJ, Citi L, Hartnack KE, Sampson A, Purdon PL, Brown EN, Barbieri R. Instantaneous monitoring of heart beat dynamics during anesthesia and sedation. Journal of Computational Surgery. 2014; 13(3).
  97. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014 Nov; 121(5):990-8. PMID: 25233374.
    Citations: 84     Fields:    Translation:Humans
  98. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999.
    Citations: 53     Fields:    Translation:Humans
  99. Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K. Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicol Teratol. 2014 May-Jun; 43:59-68. PMID: 24746641.
    Citations: 4     Fields:    Translation:AnimalsCells
  100. Akeju O, Brown EN. Awakened by a sleeping pill. Elife. 2013 Nov 19; 2:e01658. PMID: 24252876.
    Citations:    Fields:    Translation:Humans
  101. Akeju O, Alston TA. Stemming electrical outage in myocardial infarction. Crit Care Med. 2011 May; 39(5):1222-3. PMID: 21610588.
    Citations:    Fields:    Translation:HumansAnimalsCells
  102. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52. PMID: 17440165.
    Citations: 19     Fields:    Translation:HumansCells
  103. Park DM, Li J, Okamoto H, Akeju O, Kim SH, Lubensky I, Vortmeyer A, Dambrosia J, Weil RJ, Oldfield EH, Park JK, Zhuang Z. N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. Cell Cycle. 2007 Feb 15; 6(4):467-70. PMID: 17312396.
    Citations: 33     Fields:    Translation:HumansCells
  104. Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158. PMID: 16526403.
    Citations:    Fields:    Translation:Cells
  105. Yan L, Ge H, Li H, Lieber SC, Natividad F, Resuello RR, Kim SJ, Akeju S, Sun A, Loo K, Peppas AP, Rossi F, Lewandowski ED, Thomas AP, Vatner SF, Vatner DE. Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts. J Mol Cell Cardiol. 2004 Nov; 37(5):921-9. PMID: 15522269.
    Citations: 38     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.