Harvard Catalyst Profiles

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Oluwaseun Johnson-Akeju, M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG053582 (JOHNSON-AKEJU, OLUWASEUN) Sep 1, 2016 - May 31, 2021
    Pathophysiology of postoperative delirium and the use of biomimetic sleep as a treatment strategy in the CSICU
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hahm EY, Chamadia S, Locascio JJ, Pedemonte JC, Gitlin J, Mekonnen J, Ibala R, Ethridge BR, Colon KM, Qu J, Akeju O. Dissociative and analgesic properties of ketamine are independent and unaltered by sevoflurane general anesthesia. Pain Rep. 2021 Jul-Aug; 6(2):e936. PMID: 34104842.
  2. Pedemonte JC, Sun H, Franco-Garcia E, Zhou C, Heng M, Quraishi S, Westover B, Akeju O. Postoperative delirium mediates 180-day mortality in orthopaedic trauma patients. Br J Anaesth. 2021 May 29. PMID: 34074525.
    Citations:    Fields:    
  3. Kato R, Zhang ER, Mallari OG, Moody OA, Vincent KF, Melonakos ED, Siegmann MJ, Nehs CJ, Houle TT, Akeju O, Solt K. D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats. Front Pharmacol. 2021; 12:668285. PMID: 34084141.
  4. Torrado-Carvajal A, Toschi N, Albrecht DS, Chang K, Akeju O, Kim M, Edwards RR, Zhang Y, Hooker JM, Duggento A, Kalpathy-Cramer J, Napadow V, Loggia ML. Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain. Pain. 2021 04 01; 162(4):1241-1249. PMID: 33065737.
    Citations: 2     Fields:    Translation:Humans
  5. Ibala R, Mekonnen J, Gitlin J, Hahm EY, Ethridge BR, Colon KM, Marota S, Ortega C, Pedemonte JC, Cobanaj M, Chamadia S, Qu J, Gao L, Barbieri R, Akeju O. A polysomnography study examining the association between sleep and postoperative delirium in older hospitalized cardiac surgical patients. J Sleep Res. 2021 Mar 24; e13322. PMID: 33759264.
    Citations:    Fields:    
  6. Rong A, Franco-Garcia E, Zhou C, Heng M, Akeju O, Azocar RJ, Quraishi SA. Association of nutrition status and hospital-acquired infections in older adult orthopedic trauma patients. JPEN J Parenter Enteral Nutr. 2021 Mar 04. PMID: 33660849.
    Citations:    Fields:    
  7. Pedemonte JC, Locascio JJ, Houle T, Akeju O. Burst-suppression and Postoperative Delirium: Reply. Anesthesiology. 2021 02 01; 134(2):352-353. PMID: 33433617.
    Citations:    Fields:    Translation:Humans
  8. Kim MC, Fricchione GL, Akeju O. Accidental awareness under general anaesthesia: Incidence, risk factors, and psychological management. BJA Educ. 2021 Apr; 21(4):154-161. PMID: 33777414.
  9. Gao L, Gaba A, Cui L, Yang HW, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Lo MT, Hu K, Li P. Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank. J Am Heart Assoc. 2021 Feb 02; 10(3):e018483. PMID: 33461311.
    Citations: 1     Fields:    
  10. Weerasekera A, Morrissey E, Kim M, Saha A, Lin Y, Alshelh Z, Torrado-Carvajal A, Albrecht D, Akeju O, Kwon YM, Bedair H, Chen AF, Napadow V, Schreiber K, Ratai EM, Edwards RR, Loggia ML. Thalamic neurometabolite alterations in patients with knee osteoarthritis before and after total knee replacement. Pain. 2021 Jan 15. PMID: 33470749.
    Citations:    Fields:    
  11. Rao RC, Dlouhy BJ, Capell BC, Akeju O. The endangered physician-scientist and COVID-19. Cell Rep Med. 2021 Feb 16; 2(2):100190. PMID: 33521693.
  12. Sydnor VJ, Lyall AE, Cetin-Karayumak S, Cheung JC, Felicione JM, Akeju O, Shenton ME, Deckersbach T, Ionescu DF, Pasternak O, Cusin C, Kubicki M. Studying pre-treatment and ketamine-induced changes in white matter microstructure in the context of ketamine's antidepressant effects. Transl Psychiatry. 2020 12 15; 10(1):432. PMID: 33319774.
    Citations:    Fields:    
  13. Chamadia S, Pedemonte JC, Hobbs LE, Deng H, Nguyen S, Cortinez LI, Akeju O. A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine. Anesthesiology. 2020 12 01; 133(6):1223-1233. PMID: 32986820.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  14. Chamadia S, Hobbs L, Marota S, Ibala R, Hahm E, Gitlin J, Mekonnen J, Ethridge B, Colon KM, Sheppard KS, Manoach DS, DiBiasio A, Nguyen S, Pedemonte JC, Akeju O. Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans. Anesthesiology. 2020 12 01; 133(6):1234-1243. PMID: 33001139.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  15. Gitlin J, Chamadia S, Locascio JJ, Ethridge BR, Pedemonte JC, Hahm EY, Ibala R, Mekonnen J, Colon KM, Qu J, Akeju O. Dissociative and Analgesic Properties of Ketamine Are Independent. Anesthesiology. 2020 11 01; 133(5):1021-1028. PMID: 32898213.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  16. Hogan J, Sun H, Paixao L, Westmeijer M, Sikka P, Jin J, Tesh R, Cardoso M, Cash SS, Akeju O, Thomas R, Westover MB. Night-to-night variability of sleep electroencephalography-based brain age measurements. Clin Neurophysiol. 2021 Jan; 132(1):1-12. PMID: 33248430.
    Citations:    Fields:    
  17. Althoff FC, Wachtendorf LJ, Rostin P, Santer P, Schaefer MS, Xu X, Grabitz SD, Chitilian H, Houle TT, Brat GA, Akeju O, Eikermann M. Effects of night surgery on postoperative mortality and morbidity: a multicentre cohort study. BMJ Qual Saf. 2020 Oct 07. PMID: 33028658.
    Citations: 1     Fields:    
  18. Solt K, Akeju O. The brain rhythms that detach us from reality. Nature. 2020 10; 586(7827):31-32. PMID: 32939081.
    Citations:    Fields:    Translation:Humans
  19. Hogan J, Sun H, Aboul Nour H, Jing J, Tabaeizadeh M, Shoukat M, Javed F, Kassa S, Edhi MM, Bordbar E, Gallagher J, Junior VM, Ghanta M, Shao YP, Akeju O, Cole AJ, Rosenthal ES, Zafar S, Westover MB. Burst Suppression: Causes and Effects on Mortality in Critical Illness. Neurocrit Care. 2020 10; 33(2):565-574. PMID: 32096120.
    Citations: 1     Fields:    
  20. Osho AA, Moonsamy P, Ethridge BR, Leya GA, D'Alessandro DA, Jassar AS, Villavicencio MA, Melnitchouk SI, Tolis G, Langer NB, Funamoto M, Li SS, Colon KM, Mohan N, Locascio JJ, Lubitz SA, Akeju O, Sundt TM. Rationale and Design of the Randomized Controlled Trial of New Oral Anticoagulants vs. Warfarin for post Cardiac Surgery Atrial Fibrillation: The NEW-AF Trial. Ann Surg. 2020 Sep 01. PMID: 32889881.
    Citations: 1     Fields:    
  21. Kashkooli K, Polk SL, Hahm EY, Murphy J, Ethridge BR, Gitlin J, Ibala R, Mekonnen J, Pedemonte JC, Sun H, Westover MB, Barbieri R, Akeju O, Chamadia S. Improved tracking of sevoflurane anesthetic states with drug-specific machine learning models. J Neural Eng. 2020 08 04; 17(4):046020. PMID: 32485685.
    Citations: 1     Fields:    
  22. Pedemonte JC, Plummer GS, Chamadia S, Locascio JJ, Hahm E, Ethridge B, Gitlin J, Ibala R, Mekonnen J, Colon KM, Westover MB, D'Alessandro DA, Tolis G, Houle T, Shelton KT, Qu J, Akeju O. Electroencephalogram Burst-suppression during Cardiopulmonary Bypass in Elderly Patients Mediates Postoperative Delirium. Anesthesiology. 2020 08; 133(2):280-292. PMID: 32349072.
    Citations: 2     Fields:    Translation:Humans
  23. Albutt K, Luckhurst CM, Alba GA, Hechi ME, Mokhtari A, Breen K, Wing J, Akeju O, Kalva SP, Mullen JT, Lillemoe KD, Kaafarani H. Design and Impact of a COVID-19 Multidisciplinary Bundled Procedure Team. Ann Surg. 2020 08; 272(2):e72-e73. PMID: 32675501.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  24. Sun H, Ganglberger W, Panneerselvam E, Leone MJ, Quadri SA, Goparaju B, Tesh RA, Akeju O, Thomas RJ, Westover MB. Sleep staging from electrocardiography and respiration with deep learning. Sleep. 2020 07 13; 43(7). PMID: 31863111.
    Citations: 3     Fields:    
  25. Conti A, Akeju O, Duggento A, Chamadia S, Barbieri R, Toschi N. Frequency dependent functional brain reorganization in anesthesia is specific to drug concentration. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:2921-2924. PMID: 33018618.
    Citations:    Translation:Humans
  26. Kim MC, Fricchione GL, Brown EN, Akeju O. Corrigendum to 'Role of electroencephalogram oscillations and the spectrogram in monitoring anaesthesia' [BJA Education 20 (2020) 166-172]. BJA Educ. 2020 Jul; 20(7):249. PMID: 33465181.
  27. Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA. Extra-Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura. Ann Neurol. 2020 06; 87(6):939-949. PMID: 32239542.
    Citations: 3     Fields:    Translation:Humans
  28. Oh ES, Akeju O, Avidan MS, Cunningham C, Hayden KM, Jones RN, Khachaturian AS, Khan BA, Marcantonio ER, Needham DM, Neufeld KJ, Rose L, Spence J, Tieges Z, Vlisides P, Inouye SK. A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank. Alzheimers Dement. 2020 05; 16(5):726-733. PMID: 32291901.
    Citations: 4     Fields:    
  29. Thevathasan T, Grabitz SD, Santer P, Rostin P, Akeju O, Boghosian JD, Gill M, Isaacs L, Cotten JF, Eikermann M. Calabadion 1 selectively reverses respiratory and central nervous system effects of fentanyl in a rat model. Br J Anaesth. 2020 07; 125(1):e140-e147. PMID: 32241547.
    Citations: 4     Fields:    Translation:Animals
  30. Eikermann M, Akeju O, Chamberlin NL. Sleep and Anesthesia: The Shared Circuit Hypothesis Has Been Put to Bed. Curr Biol. 2020 03 09; 30(5):R219-R221. PMID: 32155424.
    Citations: 3     Fields:    Translation:Cells
  31. Kim MC, Fricchione GL, Brown EN, Akeju O. Role of electroencephalogram oscillations and the spectrogram in monitoring anaesthesia. BJA Educ. 2020 May; 20(5):166-172. PMID: 33456946.
  32. Alshelh Z, Albrecht DS, Bergan C, Akeju O, Clauw DJ, Conboy L, Edwards RR, Kim M, Lee YC, Protsenko E, Napadow V, Sullivan K, Loggia ML. In-vivo imaging of neuroinflammation in veterans with Gulf War illness. Brain Behav Immun. 2020 07; 87:498-507. PMID: 32027960.
    Citations: 14     Fields:    Translation:HumansCells
  33. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019; 2:415. PMID: 31754645.
    Citations: 6     Translation:HumansCells
  34. Zheng WL, Sun H, Akeju O, Westover MB. Adaptive Sedation Monitoring From EEG in ICU Patients With Online Learning. IEEE Trans Biomed Eng. 2020 06; 67(6):1696-1706. PMID: 31545708.
    Citations:    Fields:    
  35. Sun H, Kimchi E, Akeju O, Nagaraj SB, McClain LM, Zhou DW, Boyle E, Zheng WL, Ge W, Westover MB. Automated tracking of level of consciousness and delirium in critical illness using deep learning. NPJ Digit Med. 2019; 2:89. PMID: 31508499.
    Citations: 5     
  36. Kashkooli K, Polk SL, Chamadia S, Hahm E, Ethridge B, Gitlin J, Ibala R, Mekonnen J, Pedemonte J, Murphy JM, Sun H, Westover MB, Akeju O. Drug-Specific Models Improve the Performance of an EEG-based Automated Brain-State Prediction System. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:5808-5811. PMID: 31947172.
    Citations: 1     Translation:Humans
  37. Polk SL, Kashkooli K, Nagaraj SB, Chamadia S, Murphy JM, Sun H, Westover MB, Barbieri R, Akeju O. Automatic Detection of General Anesthetic-States using ECG-Derived Autonomic Nervous System Features. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:2019-2022. PMID: 31946297.
    Citations:    Translation:Humans
  38. Fadayomi AB, Johnson-Akeju O. The authors reply. Crit Care Med. 2019 06; 47(6):e530-e531. PMID: 31095026.
    Citations:    Fields:    Translation:Humans
  39. Albrecht DS, Kim M, Akeju O, Torrado-Carvajal A, Edwards RR, Zhang Y, Bergan C, Protsenko E, Kucyi A, Wasan AD, Hooker JM, Napadow V, Loggia ML. The neuroinflammatory component of negative affect in patients with chronic pain. Mol Psychiatry. 2021 03; 26(3):864-874. PMID: 31138890.
    Citations: 5     Fields:    Translation:HumansCells
  40. Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Loggia ML, Hadjikhani N. Imaging of neuroinflammation in migraine with aura: A [11C]PBR28 PET/MRI study. Neurology. 2019 04 23; 92(17):e2038-e2050. PMID: 30918090.
    Citations: 5     Fields:    Translation:Humans
  41. Nozari A, Akeju O, Mirzakhani H, Eskandar E, Ma Z, Hossain MA, Wang Q, Greenblatt DJ, Martyn JAJ. Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl. J Pharm Pharmacol. 2019 Jun; 71(6):982-987. PMID: 30793320.
    Citations: 2     Fields:    Translation:Humans
  42. Fadayomi AB, Ibala R, Bilotta F, Westover MB, Akeju O. A Systematic Review and Meta-Analysis Examining the Impact of Sleep Disturbance on Postoperative Delirium. Crit Care Med. 2018 12; 46(12):e1204-e1212. PMID: 30222634.
    Citations: 10     Fields:    Translation:Humans
  43. Plummer GS, Ibala R, Hahm E, An J, Gitlin J, Deng H, Shelton KT, Solt K, Qu JZ, Akeju O. Electroencephalogram dynamics during general anesthesia predict the later incidence and duration of burst-suppression during cardiopulmonary bypass. Clin Neurophysiol. 2019 01; 130(1):55-60. PMID: 30476711.
    Citations: 2     Fields:    Translation:Humans
  44. Sun H, Paixao L, Oliva JT, Goparaju B, Carvalho DZ, van Leeuwen KG, Akeju O, Thomas RJ, Cash SS, Bianchi MT, Westover MB. Brain age from the electroencephalogram of sleep. Neurobiol Aging. 2019 02; 74:112-120. PMID: 30448611.
    Citations: 13     Fields:    Translation:Humans
  45. Fadayomi AB, Akeju O. Anesthesia for stroke rescue. Curr Opin Anaesthesiol. 2018 Oct; 31(5):544-548. PMID: 30020156.
    Citations:    Fields:    Translation:Humans
  46. Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C. Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial. J Affect Disord. 2019 01 15; 243:516-524. PMID: 30286416.
    Citations: 17     Fields:    Translation:Humans
  47. Albrecht DS, Forsberg A, Sandström A, Bergan C, Kadetoff D, Protsenko E, Lampa J, Lee YC, Höglund CO, Catana C, Cervenka S, Akeju O, Lekander M, Cohen G, Halldin C, Taylor N, Kim M, Hooker JM, Edwards RR, Napadow V, Kosek E, Loggia ML. Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation. Brain Behav Immun. 2019 01; 75:72-83. PMID: 30223011.
    Citations: 38     Fields:    Translation:HumansCells
  48. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    Citations: 5     Fields:    Translation:Humans
  49. Sun H, Nagaraj SB, Akeju O, Purdon PL, Westover BM. Brain Monitoring of Sedation in the Intensive Care Unit Using a Recurrent Neural Network. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:1-4. PMID: 30440304.
    Citations: 2     Translation:Humans
  50. Gritti P, Akeju O, Lorini FL, Lanterna LA, Brembilla C, Bilotta F. A Narrative Review of Adherence to Subarachnoid Hemorrhage Guidelines. J Neurosurg Anesthesiol. 2018 Jul; 30(3):203-216. PMID: 28816882.
    Citations: 1     Fields:    Translation:Humans
  51. Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O. Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial. BMJ Open. 2018 04 20; 8(4):e020316. PMID: 29678977.
    Citations: 10     Fields:    Translation:Humans
  52. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 07; 121(1):325-327. PMID: 29935587.
    Citations: 4     Fields:    
  53. Nagaraj SB, McClain LM, Boyle EJ, Zhou DW, Ramaswamy SM, Biswal S, Akeju O, Purdon PL, Westover MB. Electroencephalogram Based Detection of Deep Sedation in ICU Patients Using Atomic Decomposition. IEEE Trans Biomed Eng. 2018 12; 65(12):2684-2691. PMID: 29993386.
    Citations: 2     Fields:    Translation:Humans
  54. Gritti P, Akeju O, Lorini FL, Lanterna A, Brembilla C, Bilotta F. Breaking the rules: is it the neurointensivists' turn? Crit Care. 2018 01 29; 22(1):21. PMID: 29378635.
    Citations:    Fields:    Translation:Humans
  55. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN. Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Clin Neurophysiol. 2018 01; 129(1):69-78. PMID: 29154132.
    Citations: 14     Fields:    Translation:Humans
  56. Lewis LD, Akeju O. Hierarchy in disruption of large-scale networks across altered arousal states. Br J Anaesth. 2017 10 01; 119(4):566-568. PMID: 29121309.
    Citations: 1     Fields:    
  57. Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC. Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity. Br J Anaesth. 2017 09 01; 119(3):443-447. PMID: 28969326.
    Citations: 6     Fields:    Translation:HumansAnimals
  58. Albrecht DS, Normandin MD, Shcherbinin S, Wooten DW, Schwarz AJ, Zürcher NR, Barth VN, Guehl NJ, Akeju O, Atassi N, Veronese M, Turkheimer F, Hooker JM, Loggia ML. Pseudoreference Regions for Glial Imaging with 11C-PBR28: Investigation in 2 Clinical Cohorts. J Nucl Med. 2018 01; 59(1):107-114. PMID: 28818984.
    Citations: 7     Fields:    Translation:HumansCells
  59. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 08; 127(2):293-306. PMID: 28657957.
    Citations: 11     Fields:    Translation:Humans
  60. Nagaraj SB, Biswal S, Boyle EJ, Zhou DW, McClain LM, Bajwa EK, Quraishi SA, Akeju O, Barbieri R, Purdon PL, Westover MB. Patient-Specific Classification of ICU Sedation Levels From Heart Rate Variability. Crit Care Med. 2017 Jul; 45(7):e683-e690. PMID: 28441231.
    Citations: 9     Fields:    Translation:Humans
  61. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci. 2017 07 19; 37(29):6938-6945. PMID: 28626012.
    Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
  62. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    Citations: 12     
  63. Akeju O, Brown EN. Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep. Curr Opin Neurobiol. 2017 06; 44:178-185. PMID: 28544930.
    Citations: 37     Fields:    Translation:HumansCells
  64. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    Citations: 16     Fields:    Translation:Humans
  65. Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M. Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation. Aust N Z J Psychiatry. 2017 Jan; 51(1):55-64. PMID: 26893373.
    Citations: 17     Fields:    Translation:Humans
  66. Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Chonde DB, Izquierdo Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis. Neurology. 2016 Dec 13; 87(24):2554-2561. PMID: 27837005.
    Citations: 32     Fields:    Translation:HumansCells
  67. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    Citations: 26     Fields:    Translation:HumansCTClinical Trials
  68. Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 06; 77(6):e719-25. PMID: 27232360.
    Citations: 23     Fields:    Translation:Humans
  69. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861.
    Citations: 30     Fields:    Translation:Humans
  70. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81. PMID: 27178867.
    Citations: 15     Fields:    Translation:Humans
  71. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8. PMID: 26284863.
    Citations: 1     Fields:    Translation:Humans
  72. Akeju O, Pavone KJ, Thum JA, Firth PG, Westover MB, Puglia M, Shank ES, Brown EN, Purdon PL. Age-dependency of sevoflurane-induced electroencephalogram dynamics in children. Br J Anaesth. 2015 Jul; 115 Suppl 1:i66-i76. PMID: 26174303.
    Citations: 16     Fields:    Translation:Humans
  73. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57. PMID: 26174300.
    Citations: 55     Fields:    Translation:Humans
  74. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564. PMID: 26118489.
    Citations: 17     Fields:    Translation:Humans
  75. Zürcher NR, Loggia ML, Lawson R, Chonde DB, Izquierdo-Garcia D, Yasek JE, Akeju O, Catana C, Rosen BR, Cudkowicz ME, Hooker JM, Atassi N. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage Clin. 2015; 7:409-14. PMID: 25685708.
    Citations: 77     Fields:    Translation:HumansCells
  76. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914. PMID: 25649968.
    Citations: 8     Fields:    Translation:Humans
  77. Loggia ML, Chonde DB, Akeju O, Arabasz G, Catana C, Edwards RR, Hill E, Hsu S, Izquierdo-Garcia D, Ji RR, Riley M, Wasan AD, Zürcher NR, Albrecht DS, Vangel MG, Rosen BR, Napadow V, Hooker JM. Evidence for brain glial activation in chronic pain patients. Brain. 2015 Mar; 138(Pt 3):604-15. PMID: 25582579.
    Citations: 120     Fields:    Translation:HumansCells
  78. Zhou DW, Westover MB, McClain LM, Nagaraj SB, Bajwa EK, Quraishi SA, Akeju O, Cobb JP, Purdon PL. Clustering analysis to identify distinct spectral components of encephalogram burst suppression in critically ill patients. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:7258-61. PMID: 26737967.
    Citations:    Translation:Humans
  79. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022.
    Citations: 45     Fields:    Translation:Humans
  80. Valenza G, Akeju O, Pavone KJ, Citi L, Hartnack KE, Sampson A, Purdon PL, Brown EN, Barbieri R. Instantaneous monitoring of heart beat dynamics during anesthesia and sedation. Journal of Computational Surgery. 2014; 13(3).
  81. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014 Nov; 121(5):990-8. PMID: 25233374.
    Citations: 61     Fields:    Translation:Humans
  82. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999.
    Citations: 47     Fields:    Translation:Humans
  83. Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K. Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicol Teratol. 2014 May-Jun; 43:59-68. PMID: 24746641.
    Citations: 4     Fields:    Translation:AnimalsCells
  84. Akeju O, Brown EN. Awakened by a sleeping pill. Elife. 2013 Nov 19; 2:e01658. PMID: 24252876.
    Citations:    Fields:    Translation:Humans
  85. Akeju O, Alston TA. Stemming electrical outage in myocardial infarction. Crit Care Med. 2011 May; 39(5):1222-3. PMID: 21610588.
    Citations:    Fields:    Translation:HumansAnimalsCells
  86. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52. PMID: 17440165.
    Citations: 19     Fields:    Translation:HumansCells
  87. Park DM, Li J, Okamoto H, Akeju O, Kim SH, Lubensky I, Vortmeyer A, Dambrosia J, Weil RJ, Oldfield EH, Park JK, Zhuang Z. N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. . 2007 Feb 15; 6(4):467-70. PMID: 17312396.
    Citations: 31     Translation:HumansCells
  88. Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158. PMID: 16526403.
    Citations:    Fields:    Translation:Cells
  89. Yan L, Ge H, Li H, Lieber SC, Natividad F, Resuello RR, Kim SJ, Akeju S, Sun A, Loo K, Peppas AP, Rossi F, Lewandowski ED, Thomas AP, Vatner SF, Vatner DE. Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts. J Mol Cell Cardiol. 2004 Nov; 37(5):921-9. PMID: 15522269.
    Citations: 32     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.