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Manoj T. Duraisingh, Ph.D.

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Biography
Wadham College, University of Oxford, Oxford, United KingdomB.A.Hons1993
London School of Hygiene and Tropical Medicine, London, United KingdomM.Sc.1994
London School of Hygiene and Tropical Medicine, London, United KingdomPhD1999

Overview
Malaria remains one of the most serious infectious diseases of humans with an estimated 500 million new infections and approximately 2 million deaths each year. We are interested in understanding the processes that underlie the pathogenesis of human malarial disease at the cellular and molecular level.

Plasmodium falciparum is a protozoan parasite, which multiplies exponentially in red blood cells (erythrocytes) in the course of its life-cycle, resulting in the clinical symptoms associated with severe malaria. We have developed transfection-based molecular and cell biological tools for the functional analysis of genes that may be involved in the initiation and progression of disease. We are also developing forward genetic screens for the identification of new molecules associated with virulence. These advances have coincided with the complete sequencing of the P. falciparum genome, which provides us with a blueprint to unravel the unique biology and genetics of this organism.

In the laboratory, we focus on the molecular basis of erythrocyte invasion by P. falciparum. To initiate a blood-stage infection, invasive forms (known as merozoites) recognize multiple receptors on the surface of the erythrocyte, after which they signal to initiate a cascade of intracellular events to complete the invasion process. We are interested in elucidating the functions of the molecules involved in this complex process. Such an understanding is a prerequisite for the rational design of vaccines directed against this life-cycle stage.

Also of interest is the regulation of antigenic variation in P. falciparum-infected erythrocytes. Following invasion, P. falciparum remodels the infected erythrocyte with the export of various proteins to the erythrocyte surface. Amongst these is a family of molecules, encoded by the var gene family, that are central both to the adherence of infected cells to specific human endothelial receptors and to the evasion of host immune responses raised against this adhesin. We are studying the mechanisms of gene silencing that lead to the mutually exclusive expression of a single member of the var gene family. This includes an understanding of the unique telomere biology of the parasite.

We also have a long-standing interest in elucidating the molecular basis of P. falciparum drug-resistance. In the absence of an effective vaccine, chemotherapy is the mainstay of malaria treatment. This is becomingly increasingly compromised through the development and spread of antimalarial resistance.

We are engaged in field projects with collaborators in malaria-endemic areas, including Senegal, Nigeria and Tanzania, to determine the relevance of our laboratory findings in different epidemiological settings.

Mentoring
Genetic analysis of how Duffy antigen expression level affects erythrocyte susceptibility to vivax malaria infection
Summer, 06/20/11 - 08/12/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI153945 (DURAISINGH, MANOJ T) Jun 12, 2020 - May 31, 2022
    NIH
    Developing comparative chemical genomics and genetic validation tools for Babesia spp.
    Role: Principal Investigator
  2. R01AI140751 (DURAISINGH, MANOJ T) Jul 1, 2018 - Jun 30, 2023
    NIH
    Elucidating ligand-receptor interactions required for Plasmodium vivax blood-stage infection
    Role: Principal Investigator
  3. R21AI139973 (DURAISINGH, MANOJ T) Jun 12, 2018 - May 31, 2020
    NIH
    Forward genetic overexpression screens to identify parasite determinants of antimalarial susceptibility
    Role: Principal Investigator
  4. R01AI138551 (DURAISINGH, MANOJ T) Feb 20, 2018 - Jan 31, 2023
    NIH
    Functional analysis of epigenetic regulators of malaria blood-stage proliferation and transmission
    Role: Principal Investigator
  5. R01HL139337 (DURAISINGH, MANOJ T) Apr 20, 2017 - Jan 31, 2021
    NIH
    Functional analysis of red blood cell determinants of Plasmodium invasion
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gnangnon B, Duraisingh MT, Buckee CO. Deconstructing the parasite multiplication rate of Plasmodium falciparum. Trends Parasitol. 2021 Jun 09. PMID: 34119440.
    Citations:    Fields:    
  2. Kanjee U, Grüring C, Babar P, Meyers A, Dash R, Pereira L, Mascarenhas A, Chaand M, Rangel GW, Clark MA, Chery L, Gomes E, Rathod PK, Duraisingh MT. Plasmodium vivax Strains Use Alternative Pathways for Invasion. J Infect Dis. 2021 May 28; 223(10):1817-1821. PMID: 32941614.
    Citations: 1     Fields:    
  3. Buyon LE, Elsworth B, Duraisingh MT. The molecular basis of antimalarial drug resistance in Plasmodium vivax. Int J Parasitol Drugs Drug Resist. 2021 Aug; 16:23-37. PMID: 33957488.
    Citations: 1     Fields:    
  4. Tennessen JA, Duraisingh MT. Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes. Mol Biol Evol. 2021 04 13; 38(4):1356-1371. PMID: 33185667.
    Citations:    Fields:    Translation:Humans
  5. Gubbels MJ, Coppens I, Zarringhalam K, Duraisingh MT, Engelberg K. The Modular Circuitry of Apicomplexan Cell Division Plasticity. Front Cell Infect Microbiol. 2021; 11:670049. PMID: 33912479.
    Citations:    Fields:    Translation:AnimalsCells
  6. Clark MA, Kanjee U, Rangel GW, Chery L, Mascarenhas A, Gomes E, Rathod PK, Brugnara C, Ferreira MU, Duraisingh MT. Plasmodium vivax infection compromises reticulocyte stability. Nat Commun. 2021 03 12; 12(1):1629. PMID: 33712609.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Proto WR, Siegel SV, Dankwa S, Liu W, Kemp A, Marsden S, Zenonos ZA, Unwin S, Sharp PM, Wright GJ, Hahn BH, Duraisingh MT, Rayner JC. Author Correction: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand. Nat Commun. 2021 Feb 16; 12(1):1188. PMID: 33594063.
    Citations:    Fields:    
  8. Elsworth B, Duraisingh MT. A framework for signaling throughout the life cycle of Babesia species. Mol Microbiol. 2021 05; 115(5):882-890. PMID: 33274587.
    Citations: 1     Fields:    
  9. Kumar M, Skillman K, Duraisingh MT. Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites. Mol Microbiol. 2021 05; 115(5):891-900. PMID: 33236377.
    Citations: 1     Fields:    
  10. Anderson TJC, Duraisingh MT. Transformative tools for parasitic flatworms. Science. 2020 09 25; 369(6511):1562-1564. PMID: 32973017.
    Citations:    Fields:    Translation:Animals
  11. Paul AS, Miliu A, Paulo JA, Goldberg JM, Bonilla AM, Berry L, Seveno M, Braun-Breton C, Kosber AL, Elsworth B, Arriola JSN, Lebrun M, Gygi SP, Lamarque MH, Duraisingh MT. Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes. Nat Commun. 2020 07 15; 11(1):3532. PMID: 32669539.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Hung J, Goodman A, Ravel D, Lopes SCP, Rangel GW, Nery OA, Malleret B, Nosten F, Lacerda MVG, Ferreira MU, Rénia L, Duraisingh MT, Costa FTM, Marti M, Carpenter AE. Keras R-CNN: library for cell detection in biological images using deep neural networks. BMC Bioinformatics. 2020 Jul 11; 21(1):300. PMID: 32652926.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Gubbels MJ, Keroack CD, Dangoudoubiyam S, Worliczek HL, Paul AS, Bauwens C, Elsworth B, Engelberg K, Howe DK, Coppens I, Duraisingh MT. Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes. Front Cell Infect Microbiol. 2020; 10:269. PMID: 32582569.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO. Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains. PLoS Comput Biol. 2020 04; 16(4):e1007702. PMID: 32315315.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Rangel GW, Clark MA, Kanjee U, Goldberg JM, MacInnis B, José Menezes M, Ferreira MU, Duraisingh MT. Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle. PLoS Negl Trop Dis. 2020 03; 14(3):e0008104. PMID: 32119669.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Proto WR, Siegel SV, Dankwa S, Liu W, Kemp A, Marsden S, Zenonos ZA, Unwin S, Sharp PM, Wright GJ, Hahn BH, Duraisingh MT, Rayner JC. Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand. Nat Commun. 2019 10 04; 10(1):4512. PMID: 31586047.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Ravenhill BJ, Kanjee U, Ahouidi A, Nobre L, Williamson J, Goldberg JM, Antrobus R, Dieye T, Duraisingh MT, Weekes MP. Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations. Commun Biol. 2019 Sep 20; 2(1):350. PMID: 31925190.
    Citations:    
  18. Ravenhill BJ, Kanjee U, Ahouidi A, Nobre L, Williamson J, Goldberg JM, Antrobus R, Dieye T, Duraisingh MT, Weekes MP. Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations. Commun Biol. 2019; 2:350. PMID: 31552303.
    Citations: 3     Translation:HumansCells
  19. Archer NM, Petersen N, Duraisingh MT. Fetal hemoglobin does not inhibit Plasmodium falciparum growth. Blood Adv. 2019 07 23; 3(14):2149-2152. PMID: 31311778.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Scully EJ, Shabani E, Rangel GW, Grüring C, Kanjee U, Clark MA, Chaand M, Kurita R, Nakamura Y, Ferreira MU, Duraisingh MT. Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion. Am J Hematol. 2019 09; 94(9):963-974. PMID: 31148215.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Elsworth B, Keroack CD, Duraisingh MT. Elucidating Host Cell Uptake by Malaria Parasites. Trends Parasitol. 2019 05; 35(5):333-335. PMID: 31003757.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF. Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex. Nature. 2019 01; 565(7737):118-121. PMID: 30542156.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  23. Keroack CD, Elsworth B, Duraisingh MT. To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia. Int J Parasitol. 2019 02; 49(2):153-163. PMID: 30391230.
    Citations: 4     Fields:    Translation:HumansAnimals
  24. Kanjee U, Rangel GW, Clark MA, Duraisingh MT. Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes. Curr Opin Microbiol. 2018 12; 46:109-115. PMID: 30366310.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  25. Archer NM, Petersen N, Clark MA, Buckee CO, Childs LM, Duraisingh MT. Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):7350-7355. PMID: 29946035.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  26. Duraisingh MT, Skillman KM. Epigenetic Variation and Regulation in Malaria Parasites. Annu Rev Microbiol. 2018 Sep 08; 72:355-375. PMID: 29927705.
    Citations: 10     Fields:    Translation:HumansAnimals
  27. Obaldia N, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, Marti M. Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. mBio. 2018 05 08; 9(3). PMID: 29739900.
    Citations: 46     Fields:    Translation:HumansAnimals
  28. Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT. Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Commun Biol. 2018; 1:45. PMID: 30271928.
    Citations: 6     
  29. Rangel GW, Clark MA, Kanjee U, Lim C, Shaw-Saliba K, Menezes MJ, Mascarenhas A, Chery L, Gomes E, Rathod PK, Ferreira MU, Duraisingh MT. Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays. Antimicrob Agents Chemother. 2018 04; 62(4). PMID: 29378713.
    Citations: 14     Fields:    Translation:HumansAnimals
  30. Patankar S, Sharma S, Rathod PK, Duraisingh MT. Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax. Proteomics Clin Appl. 2018 07; 12(4):e1700024. PMID: 29193853.
    Citations:    Fields:    Translation:HumansAnimals
  31. Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 01 05; 359(6371):48-55. PMID: 29302006.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  32. Paul AS, Duraisingh MT. Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry. Trends Parasitol. 2018 02; 34(2):95-97. PMID: 29269028.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  33. Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Dec 14; 171(7):1532-1544.e15. PMID: 29129376.
    Citations: 67     Fields:    Translation:HumansAnimals
  34. Lim C, Dankwa S, Paul AS, Duraisingh MT. Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination. Cold Spring Harb Perspect Med. 2017 Nov 01; 7(11). PMID: 28213436.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  35. Scully EJ, Kanjee U, Duraisingh MT. Molecular interactions governing host-specificity of blood stage malaria parasites. Curr Opin Microbiol. 2017 Dec; 40:21-31. PMID: 29096194.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  36. Kanjee U, Grüring C, Chaand M, Lin KM, Egan E, Manzo J, Jones PL, Yu T, Barker R, Weekes MP, Duraisingh MT. CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9356-E9365. PMID: 29078358.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  37. Dankwa S, Chaand M, Kanjee U, Jiang RHY, Nobre LV, Goldberg JM, Bei AK, Moechtar MA, Grüring C, Ahouidi AD, Ndiaye D, Dieye TN, Mboup S, Weekes MP, Duraisingh MT. Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes. Infect Immun. 2017 10; 85(10). PMID: 28760933.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  38. Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT. The Molecular Basis of Erythrocyte Invasion by Malaria Parasites. . 2017 Aug 09; 22(2):232-245. PMID: 28799908.
    Citations: 61     Translation:HumansAnimalsCells
  39. Bei AK, Ahouidi AD, Dvorin JD, Miura K, Diouf A, Ndiaye D, Premji Z, Diakite M, Mboup S, Long CA, Duraisingh MT. Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen. J Infect Dis. 2017 07 15; 216(2):267-275. PMID: 28605544.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  40. Kumar S, Kumar M, Ekka R, Dvorin JD, Paul AS, Madugundu AK, Gilberger T, Gowda H, Duraisingh MT, Keshava Prasad TS, Sharma P. PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum. Nat Commun. 2017 07 05; 8(1):63. PMID: 28680058.
    Citations: 26     Fields:    Translation:AnimalsCells
  41. Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT. Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Mar 06; 2:17038. PMID: 28263306.
    Citations:    Fields:    
  42. Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT. Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Feb 17; 2:17017. PMID: 28211852.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  43. Chery L, Maki JN, Mascarenhas A, Walke JT, Gawas P, Almeida A, Fernandes M, Vaz M, Ramanan R, Shirodkar D, Bernabeu M, Manoharan SK, Pereira L, Dash R, Sharma A, Shaik RB, Chakrabarti R, Babar P, White J, Mudeppa DG, Kumar S, Zuo W, Skillman KM, Kanjee U, Lim C, Shaw-Saliba K, Kumar A, Valecha N, Jindal VN, Khandeparkar A, Naik P, Amonkar S, Duraisingh MT, Tuljapurkar S, Smith JD, Dubhashi N, Pinto RG, Silveria M, Gomes E, Rathod PK. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malar J. 2016 11 25; 15(1):569. PMID: 27884146.
    Citations: 10     Fields:    Translation:Humans
  44. Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, Rayner JC. Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications. PLoS Negl Trop Dis. 2016 Oct; 10(10):e0005091. PMID: 27798646.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  45. Mantel PY, Hjelmqvist D, Walch M, Kharoubi-Hess S, Nilsson S, Ravel D, Ribeiro M, Grüring C, Ma S, Padmanabhan P, Trachtenberg A, Ankarklev J, Brancucci NM, Huttenhower C, Duraisingh MT, Ghiran I, Kuo WP, Filgueira L, Martinelli R, Marti M. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria. Nat Commun. 2016 10 10; 7:12727. PMID: 27721445.
    Citations: 63     Fields:    Translation:HumansCells
  46. Shaw-Saliba K, Thomson-Luque R, Obaldía N, Nuñez M, Dutary S, Lim C, Barnes S, Kocken CH, Duraisingh MT, Adams JH, Pasini EM. Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model. PLoS Negl Trop Dis. 2016 07; 10(7):e0004870. PMID: 27463518.
    Citations: 7     Fields:    Translation:AnimalsCells
  47. Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. Int J Parasitol. 2016 10; 46(11):679-83. PMID: 27456552.
    Citations: 4     Fields:    Translation:HumansAnimals
  48. Paul AS, Moreira CK, Elsworth B, Allred DR, Duraisingh MT. Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites. Antimicrob Agents Chemother. 2016 08; 60(8):5059-63. PMID: 27246780.
    Citations: 7     Fields:    Translation:Animals
  49. Kumar S, Mudeppa DG, Sharma A, Mascarenhas A, Dash R, Pereira L, Shaik RB, Maki JN, White J, Zuo W, Tuljapurkar S, Duraisingh MT, Gomes E, Chery L, Rathod PK. Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Mol Biochem Parasitol. 2016 Nov - Dec; 210(1-2):1-4. PMID: 27457272.
    Citations: 2     Fields:    Translation:HumansAnimals
  50. Lim C, Pereira L, Saliba KS, Mascarenhas A, Maki JN, Chery L, Gomes E, Rathod PK, Duraisingh MT. Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates. J Infect Dis. 2016 10 01; 214(7):1081-4. PMID: 27432121.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  51. Lim C, Pereira L, Shardul P, Mascarenhas A, Maki J, Rixon J, Shaw-Saliba K, White J, Silveira M, Gomes E, Chery L, Rathod PK, Duraisingh MT. Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia. Am J Hematol. 2016 08; 91(8):852-5. PMID: 27074559.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  52. Duraisingh MT, Horn D. Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa. . 2016 May 11; 19(5):629-40. PMID: 27173931.
    Citations: 21     Translation:HumansAnimals
  53. Dankwa S, Lim C, Bei AK, Jiang RH, Abshire JR, Patel SD, Goldberg JM, Moreno Y, Kono M, Niles JC, Duraisingh MT. Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite. Nat Commun. 2016 Apr 04; 7:11187. PMID: 27041489.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  54. Sidik SM, Hortua Triana MA, Paul AS, El Bakkouri M, Hackett CG, Tran F, Westwood NJ, Hui R, Zuercher WJ, Duraisingh MT, Moreno SN, Lourido S. Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling. J Biol Chem. 2016 Apr 29; 291(18):9566-80. PMID: 26933036.
    Citations: 19     Fields:    Translation:AnimalsCells
  55. Joice R, Frantzreb C, Pradham A, Seydel KB, Kamiza S, Wirth DF, Duraisingh MT, Molyneux ME, Taylor TE, Marti M, Milner DA. Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients. Mod Pathol. 2016 Apr; 29(4):381-90. PMID: 26916076.
    Citations: 5     Fields:    Translation:Humans
  56. Obaldía N, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti M. Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Sci Rep. 2016 Feb 16; 6:21216. PMID: 26880111.
    Citations: 1     Fields:    Translation:Animals
  57. Ahouidi AD, Amambua-Ngwa A, Awandare GA, Bei AK, Conway DJ, Diakite M, Duraisingh MT, Rayner JC, Zenonos ZA. Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN). Trends Parasitol. 2016 Apr; 32(4):274-283. PMID: 26725306.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  58. Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT. The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrob Agents Chemother. 2016 01; 60(1):613-6. PMID: 26459896.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  59. Assefa S, Lim C, Preston MD, Duffy CW, Nair MB, Adroub SA, Kadir KA, Goldberg JM, Neafsey DE, Divis P, Clark TG, Duraisingh MT, Conway DJ, Pain A, Singh B. Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13027-32. PMID: 26438871.
    Citations: 32     Fields:    Translation:Animals
  60. Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):42-56. PMID: 26259939.
    Citations: 40     Fields:    Translation:HumansAnimals
  61. Paul AS, Saha S, Engelberg K, Jiang RH, Coleman BI, Kosber AL, Chen CT, Ganter M, Espy N, Gilberger TW, Gubbels MJ, Duraisingh MT. Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans. . 2015 Jul 08; 18(1):49-60. PMID: 26118996.
    Citations: 29     Translation:HumansAnimalsCells
  62. Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT. Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science. 2015 May 08; 348(6235):711-4. PMID: 25954012.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  63. Paul AS, Egan ES, Duraisingh MT. Host-parasite interactions that guide red blood cell invasion by malaria parasites. Curr Opin Hematol. 2015 May; 22(3):220-6. PMID: 25767956.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  64. Merrick CJ, Jiang RH, Skillman KM, Samarakoon U, Moore RM, Dzikowski R, Ferdig MT, Duraisingh MT. Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. PLoS One. 2015; 10(3):e0118865. PMID: 25780929.
    Citations: 9     Fields:    Translation:Animals
  65. Choi JY, Duraisingh MT, Marti M, Ben Mamoun C, Voelker DR. From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE. J Biol Chem. 2015 Apr 24; 290(17):10972-80. PMID: 25724650.
    Citations: 13     Fields:    Translation:AnimalsCells
  66. Mejia P, Treviño-Villarreal JH, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh MT, Mitchell JR. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nat Commun. 2015 Jan 30; 6:6050. PMID: 25636003.
    Citations: 28     Fields:    Translation:AnimalsCells
  67. Bei AK, Duraisingh MT. Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry. Methods Mol Biol. 2015; 1325:167-86. PMID: 26450388.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  68. Kumar AA, Lim C, Moreno Y, Mace CR, Syed A, Van Tyne D, Wirth DF, Duraisingh MT, Whitesides GM. Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers. Am J Hematol. 2015 Jan; 90(1):31-6. PMID: 25263455.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  69. Coleman BI, Skillman KM, Jiang RHY, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BFC, Marti M, Llinás M, Buckee CO, Duraisingh MT. A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. . 2014 Aug 13; 16(2):177-186. PMID: 25121747.
    Citations: 71     Translation:HumansAnimalsCells
  70. Guillén N, Duraisingh M. Editorial overview: Host-microbe interactions: parasites: sensing and responding to the changing environment: the life of protozoan parasites. Curr Opin Microbiol. 2014 Aug; 20:vii-ix. PMID: 25081632.
    Citations:    Fields:    Translation:HumansAnimals
  71. Niang M, Bei AK, Madnani KG, Pelly S, Dankwa S, Kanjee U, Gunalan K, Amaladoss A, Yeo KP, Bob NS, Malleret B, Duraisingh MT, Preiser PR. STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting. . 2014 Jul 09; 16(1):81-93. PMID: 25011110.
    Citations: 51     Translation:HumansAnimalsCells
  72. Joice R, Nilsson SK, Montgomery J, Dankwa S, Egan E, Morahan B, Seydel KB, Bertuccini L, Alano P, Williamson KC, Duraisingh MT, Taylor TE, Milner DA, Marti M. Plasmodium falciparum transmission stages accumulate in the human bone marrow. Sci Transl Med. 2014 Jul 09; 6(244):244re5. PMID: 25009232.
    Citations: 101     Fields:    Translation:HumansAnimals
  73. Grüring C, Moon RW, Lim C, Holder AA, Blackman MJ, Duraisingh MT. Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol. 2014 May; 16(5):612-20. PMID: 24506567.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  74. Horn D, Duraisingh MT. Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol. 2014; 54:71-94. PMID: 24050701.
    Citations: 15     Fields:    Translation:Humans
  75. Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MT. Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. J Infect Dis. 2013 Nov 15; 208(10):1679-87. PMID: 23904294.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  76. Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh MT, Gilberger TW. Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum. Biochem J. 2013 Jun 15; 452(3):457-66. PMID: 23544851.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  77. Badiane AS, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr O, Ndir O, Tolia NH, Mboup S, Duraisingh MT. Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway. Clin Vaccine Immunol. 2013 Aug; 20(8):1238-45. PMID: 23761656.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  78. Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT. Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nat Commun. 2013; 4:1638. PMID: 23535659.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  79. Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. . 2012 Dec 13; 12(6):739-50. PMID: 23245319.
    Citations: 11     Translation:AnimalsCells
  80. Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S. Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries. 2012 Oct 19; 6(10):727-33. PMID: 23103895.
    Citations: 1     Fields:    Translation:HumansAnimals
  81. Gubbels MJ, Duraisingh MT. Evolution of apicomplexan secretory organelles. Int J Parasitol. 2012 Nov; 42(12):1071-81. PMID: 23068912.
    Citations: 32     Fields:    Translation:AnimalsCells
  82. Vorobjev IA, Buchholz K, Prabhat P, Ketman K, Egan ES, Marti M, Duraisingh MT, Barteneva NS. Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malar J. 2012 Sep 05; 11:312. PMID: 22950515.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  83. Duraisingh MT, Lodish HF. Sickle cell microRNAs inhibit the malaria parasite. . 2012 Aug 16; 12(2):127-8. PMID: 22901533.
    Citations: 2     
  84. Bei AK, Duraisingh MT. Functional analysis of erythrocyte determinants of Plasmodium infection. Int J Parasitol. 2012 May 15; 42(6):575-82. PMID: 22726752.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  85. Merrick CJ, Huttenhower C, Buckee C, Amambua-Ngwa A, Gomez-Escobar N, Walther M, Conway DJ, Duraisingh MT. Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria. J Infect Dis. 2012 May 15; 205(10):1593-600. PMID: 22448008.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  86. Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod PK. Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop. 2012 Mar; 121(3):256-66. PMID: 22266213.
    Citations: 9     Fields:    Translation:HumansAnimalsPHPublic Health
  87. Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Ferguson DJ, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels MJ. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 2012 Jan 13; 335(6065):218-21. PMID: 22246776.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  88. Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10. PMID: 22195562.
    Citations: 21     Fields:    Translation:AnimalsCells
  89. Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar; 121(3):175-83. PMID: 22142790.
    Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
  90. Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop. 2012 Mar; 121(3):166-74. PMID: 22119584.
    Citations: 14     Fields:    Translation:HumansAnimalsPHPublic Health
  91. Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature. 2011 Nov 09; 480(7378):534-7. PMID: 22080952.
    Citations: 266     Fields:    Translation:HumansAnimalsCells
  92. Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol. 2011 Jun 20; 12(6):R56. PMID: 21689454.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  93. Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Jun; 55(6):2612-22. PMID: 21422215.
    Citations: 11     Fields:    Translation:HumansAnimals
  94. Comeaux CA, Coleman BI, Bei AK, Whitehurst N, Duraisingh MT. Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth. Mol Microbiol. 2011 Apr; 80(2):378-90. PMID: 21320181.
    Citations: 25     Fields:    Translation:Animals
  95. Bei AK, Brugnara C, Duraisingh MT. In vitro genetic analysis of an erythrocyte determinant of malaria infection. J Infect Dis. 2010 Dec 01; 202(11):1722-7. PMID: 20958212.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  96. Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22; 285(43):33054-33064. PMID: 20702404.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  97. Merrick CJ, Duraisingh MT. Epigenetics in Plasmodium: what do we really know? Eukaryot Cell. 2010 Aug; 9(8):1150-8. PMID: 20562224.
    Citations: 20     Fields:    Translation:HumansAnimals
  98. Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010 May 14; 328(5980):910-2. PMID: 20466936.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  99. Bei AK, Desimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT. A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol. 2010 Apr; 85(4):234-7. PMID: 20196166.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  100. Dvorin JD, Bei AK, Coleman BI, Duraisingh MT. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 Feb; 75(4):990-1006. PMID: 20487292.
    Citations: 19     Fields:    Translation:AnimalsCells
  101. Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 2010 Feb 26; 285(9):6857-66. PMID: 20042598.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  102. Ahouidi AD, Bei AK, Neafsey DE, Sarr O, Volkman S, Milner D, Cox-Singh J, Ferreira MU, Ndir O, Premji Z, Mboup S, Duraisingh MT. Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infect Genet Evol. 2010 Mar; 10(2):200-6. PMID: 19931645.
    Citations: 14     Fields:    Translation:HumansAnimals
  103. Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J. Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010 Feb; 9(2):228-41. PMID: 19783771.
    Citations: 45     Fields:    Translation:Animals
  104. Merrick CJ, Dzikowski R, Imamura H, Chuang J, Deitsch K, Duraisingh MT. The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. Int J Parasitol. 2010 Jan; 40(1):35-43. PMID: 19666023.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  105. DeSimone TM, Jennings CV, Bei AK, Comeaux C, Coleman BI, Refour P, Triglia T, Stubbs J, Cowman AF, Duraisingh MT. Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Mol Microbiol. 2009 May; 72(3):578-89. PMID: 19400777.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  106. Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009 Apr 23; 52(8):2185-7. PMID: 19317450.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  107. Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol. 2009 Apr 14; 7(4):e84. PMID: 19402747.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  108. Lantos PM, Ahouidi AD, Bei AK, Jennings CV, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology. 2009 Jan; 136(1):1-9. PMID: 19126266.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  109. Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):972-5. PMID: 19097788.
    Citations: 19     Fields:    Translation:AnimalsCells
  110. Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85. PMID: 18842591.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  111. DeSimone TM, Bei AK, Jennings CV, Duraisingh MT. Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. Int J Parasitol. 2009 Mar; 39(4):399-405. PMID: 18831976.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  112. Coleman BI, Duraisingh MT. Transcriptional control and gene silencing in Plasmodium falciparum. Cell Microbiol. 2008 Oct; 10(10):1935-46. PMID: 18637022.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  113. Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One. 2008 Feb 13; 3(2):e1570. PMID: 18270564.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  114. Duraisingh MT, DeSimone T, Jennings C, Refour P, Wu C. Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching. Subcell Biochem. 2008; 47:46-57. PMID: 18512340.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  115. Comeaux CA, Duraisingh MT. Unravelling a histone code for malaria virulence. Mol Microbiol. 2007 Dec; 66(6):1291-5. PMID: 18028316.
    Citations:    Fields:    Translation:AnimalsCells
  116. Militello KT, Refour P, Comeaux CA, Duraisingh MT. Antisense RNA and RNAi in protozoan parasites: working hard or hardly working? Mol Biochem Parasitol. 2008 Feb; 157(2):117-26. PMID: 18053590.
    Citations: 23     Fields:    Translation:Animals
  117. Merrick CJ, Duraisingh MT. Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryot Cell. 2007 Nov; 6(11):2081-91. PMID: 17827348.
    Citations: 33     Fields:    Translation:AnimalsCells
  118. Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg. 2007 Aug; 77(2):201-8. PMID: 17690387.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  119. Jennings CV, Ahouidi AD, Zilversmit M, Bei AK, Rayner J, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infect Immun. 2007 Jul; 75(7):3531-8. PMID: 17470537.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  120. Bei AK, Membi CD, Rayner JC, Mubi M, Ngasala B, Sultan AA, Premji Z, Duraisingh MT. Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania. Mol Biochem Parasitol. 2007 May; 153(1):66-71. PMID: 17303262.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  121. Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF. A genome-wide map of diversity in Plasmodium falciparum. Nat Genet. 2007 Jan; 39(1):113-9. PMID: 17159979.
    Citations: 165     Fields:    Translation:HumansAnimals
  122. Merrick CJ, Duraisingh MT. Heterochromatin-mediated control of virulence gene expression. Mol Microbiol. 2006 Nov; 62(3):612-20. PMID: 17076663.
    Citations: 24     Fields:    Translation:AnimalsCells
  123. Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep; 61(5):1187-95. PMID: 16925553.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  124. Duraisingh M, Ferdig MT, Stoeckert CJ, Volkman SK, McGovern VP. Plasmodium research in the postgenomic era. Trends Parasitol. 2006 Jan; 22(1):1-4. PMID: 16311071.
    Citations: 1     Fields:    Translation:HumansAnimals
  125. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science. 2005 Aug 26; 309(5739):1384-7. PMID: 16123303.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  126. Duraisingh MT, Refour P. Multiple drug resistance genes in malaria -- from epistasis to epidemiology. Mol Microbiol. 2005 Aug; 57(4):874-7. PMID: 16091030.
    Citations: 14     Fields:    Translation:HumansAnimals
  127. Duraisingh MT, Cowman AF. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 2005 Jun; 94(3):181-90. PMID: 15876420.
    Citations: 114     Fields:    Translation:HumansAnimals
  128. Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, Thompson JK, Freitas-Junior LH, Scherf A, Crabb BS, Cowman AF. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 2005 Apr 08; 121(1):13-24. PMID: 15820675.
    Citations: 209     Fields:    Translation:HumansAnimalsCells
  129. Triglia T, Duraisingh MT, Good RT, Cowman AF. Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol. 2005 Jan; 55(1):162-74. PMID: 15612925.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  130. Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4796-801. PMID: 12672957.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  131. Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, McFadden GI, Cowman AF. Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J. 2003 Mar 03; 22(5):1047-57. PMID: 12606570.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  132. Ngo T, Duraisingh M, Reed M, Hipgrave D, Biggs B, Cowman AF. Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin. Am J Trop Med Hyg. 2003 Mar; 68(3):350-6. PMID: 12685644.
    Citations: 27     Fields:    Translation:Animals
  133. Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, Cowman AF. A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem. 2003 Apr 18; 278(16):14480-6. PMID: 12556470.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  134. Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF. Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med. 2003 Jan; 9(1):87-92. PMID: 12469115.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  135. Sutherland CJ, Alloueche A, Curtis J, Drakeley CJ, Ord R, Duraisingh M, Greenwood BM, Pinder M, Warhurst D, Targett GA. Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes. Am J Trop Med Hyg. 2002 Dec; 67(6):578-85. PMID: 12518847.
    Citations: 43     Fields:    Translation:HumansAnimals
  136. Baldi DL, Good R, Duraisingh MT, Crabb BS, Cowman AF. Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infect Immun. 2002 Sep; 70(9):5236-45. PMID: 12183575.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  137. Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, Upcroft P. Resistance to antiparasitic drugs: the role of molecular diagnosis. Int J Parasitol. 2002 May; 32(5):637-53. PMID: 11943235.
    Citations: 11     Fields:    Translation:HumansAnimals
  138. O'Donnell RA, Freitas-Junior LH, Preiser PR, Williamson DH, Duraisingh M, McElwain TF, Scherf A, Cowman AF, Crabb BS. A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J. 2002 Mar 01; 21(5):1231-9. PMID: 11867551.
    Citations: 50     Fields:    Translation:AnimalsCells
  139. Cowman AF, Baldi DL, Duraisingh M, Healer J, Mills KE, O'Donnell RA, Thompson J, Triglia T, Wickham ME, Crabb BS. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):25-33. PMID: 11839179.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  140. Duraisingh MT, Triglia T, Cowman AF. Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol. 2002 Jan; 32(1):81-9. PMID: 11796125.
    Citations: 77     Fields:    Translation:Animals
  141. Warhurst DC, Duraisingh MT. Rational use of drugs against Plasmodium falciparum. Trans R Soc Trop Med Hyg. 2001 Jul-Aug; 95(4):345-6. PMID: 11579870.
    Citations: 3     Fields:    Translation:HumansAnimals
  142. Cowman AF, Duraisingh MT. An old enemy, a new battle plan. Perspective on combating drug-resistant malaria. . 2001 Feb; 2(2):77-9. PMID: 11258713.
    Citations: 1     Translation:HumansAnimals
  143. Duraisingh MT, von Seidlein LV, Jepson A, Jones P, Sambou I, Pinder M, Warhurst DC. Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum. Parasitology. 2000 Jul; 121 ( Pt 1):1-7. PMID: 11085219.
    Citations: 21     Fields:    Translation:HumansAnimals
  144. Duraisingh MT, Roper C, Walliker D, Warhurst DC. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol. 2000 May; 36(4):955-61. PMID: 10844681.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  145. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol. 2000 Apr 30; 108(1):13-23. PMID: 10802315.
    Citations: 131     Fields:    Translation:HumansAnimals
  146. von Seidlein L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P, Doherty T. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 2000 Jan 29; 355(9201):352-7. PMID: 10665554.
    Citations: 40     Fields:    Translation:HumansAnimalsCTClinical Trials
  147. Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother. 1999 Dec; 43(12):2943-9. PMID: 10582887.
    Citations: 117     Fields:    Translation:HumansAnimals
  148. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study. Parasitology. 1999 Nov; 119 ( Pt 5):435-40. PMID: 10599075.
    Citations: 11     Fields:    Translation:HumansAnimals
  149. Jelinek T, Kilian AH, Curtis J, Duraisingh MT, Kabagambe G, von Sonnenburg F, Warhurst DC. Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children. Am J Trop Med Hyg. 1999 Jul; 61(1):125-30. PMID: 10432069.
    Citations: 12     Fields:    Translation:HumansAnimals
  150. Jelinek T, Rønn AM, Lemnge MM, Curtis J, Mhina J, Duraisingh MT, Bygbjerg IC, Warhurst DC. Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania. Trop Med Int Health. 1998 Aug; 3(8):605-9. PMID: 9735930.
    Citations: 20     Fields:    Translation:HumansAnimals
  151. Curtis J, Duraisingh MT, Warhurst DC. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. J Infect Dis. 1998 May; 177(5):1429-33. PMID: 9593041.
    Citations: 15     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  152. Duraisingh MT, Curtis J, Warhurst DC. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol. 1998 May; 89(1):1-8. PMID: 9603482.
    Citations: 101     Fields:    Translation:Animals
  153. Jelinek T, Rønn AM, Curtis J, Duraisingh MT, Lemnge MM, Mhina J, Bygbjerg IC, Warhurst DC. High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance. Trop Med Int Health. 1997 Nov; 2(11):1075-9. PMID: 9391510.
    Citations: 6     Fields:    Translation:HumansAnimals
  154. von Seidlein L, Duraisingh MT, Drakeley CJ, Bailey R, Greenwood BM, Pinder M. Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia. Trans R Soc Trop Med Hyg. 1997 Jul-Aug; 91(4):450-3. PMID: 9373652.
    Citations: 12     Fields:    Translation:HumansAnimals
  155. Duraisingh MT, Drakeley CJ, Muller O, Bailey R, Snounou G, Targett GA, Greenwood BM, Warhurst DC. Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology. 1997 Mar; 114 ( Pt 3):205-11. PMID: 9075340.
    Citations: 43     Fields:    Translation:HumansAnimalsCTClinical Trials
  156. Curtis J, Duraisingh MT, Trigg JK, Mbwana H, Warhurst DC, Curtis CF. Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania. Trans R Soc Trop Med Hyg. 1996 Nov-Dec; 90(6):678-80. PMID: 9015515.
    Citations: 6     Fields:    Translation:HumansAnimals
  157. Drakeley CJ, Duraisingh MT, Póvoa M, Conway DJ, Targett GA, Baker DA. Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate. Mol Biochem Parasitol. 1996 Oct 30; 81(2):253-7. PMID: 8898341.
    Citations: 7     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.