Harvard Catalyst Profiles

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Manoj T. Duraisingh, Ph.D.

Title
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Department
Address
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Mentoring
Genetic analysis of how Duffy antigen expression level affects erythrocyte susceptibility to vivax malaria infection
Summer, 06/20/11 - 08/12/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI140751 (DURAISINGH, MANOJ T) Jul 1, 2018 - Jun 30, 2023
    NIH/NIAID
    Elucidating ligand-receptor interactions required for Plasmodium vivax blood-stage infection
    Role: Principal Investigator
  2. R21AI139973 (DURAISINGH, MANOJ T) Jun 12, 2018 - May 31, 2020
    NIH/NIAID
    Forward genetic overexpression screens to identify parasite determinants of antimalarial susceptibility
    Role: Principal Investigator
  3. R01AI138551 (DURAISINGH, MANOJ T) Feb 20, 2018 - Jan 31, 2023
    NIH/NIAID
    Functional analysis of epigenetic regulators of malaria blood-stage proliferation and transmission
    Role: Principal Investigator
  4. R01HL139337 (DURAISINGH, MANOJ T) Apr 20, 2017 - Jan 31, 2021
    NIH/NHLBI
    Functional analysis of red blood cell determinants of Plasmodium invasion
    Role: Principal Investigator
  5. R21AI128480 (DURAISINGH, MANOJ T) Dec 15, 2016 - Nov 30, 2018
    NIH/NIAID
    Chemical genetic screening to identify synergistic inhibitors of malaria parasite cell cycle regulators
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Scully EJ, Shabani E, Rangel GW, Grüring C, Kanjee U, Clark MA, Chaand M, Kurita R, Nakamura Y, Ferreira MU, Duraisingh MT. Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion. Am J Hematol. 2019 May 31. PMID: 31148215.
    Citations:    
  2. Elsworth B, Keroack CD, Duraisingh MT. Elucidating Host Cell Uptake by Malaria Parasites. Trends Parasitol. 2019 May; 35(5):333-335. PMID: 31003757.
    Citations:    
  3. Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF. Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex. Nature. 2019 01; 565(7737):118-121. PMID: 30542156.
    Citations:    Fields:    
  4. Keroack CD, Elsworth B, Duraisingh MT. To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia. Int J Parasitol. 2019 Feb; 49(2):153-163. PMID: 30391230.
    Citations:    Fields:    
  5. Kanjee U, Rangel GW, Clark MA, Duraisingh MT. Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes. Curr Opin Microbiol. 2018 12; 46:109-115. PMID: 30366310.
    Citations:    
  6. Archer NM, Petersen N, Clark MA, Buckee CO, Childs LM, Duraisingh MT. Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):7350-7355. PMID: 29946035.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Duraisingh MT, Skillman KM. Epigenetic Variation and Regulation in Malaria Parasites. Annu Rev Microbiol. 2018 Sep 08; 72:355-375. PMID: 29927705.
    Citations:    Fields:    
  8. Obaldia N, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, Marti M. Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. MBio. 2018 05 08; 9(3). PMID: 29739900.
    Citations:    Fields:    Translation:HumansAnimals
  9. Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT. Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Commun Biol. 2018; 1:45. PMID: 30271928.
    Citations:    
  10. Rangel GW, Clark MA, Kanjee U, Lim C, Shaw-Saliba K, Menezes MJ, Mascarenhas A, Chery L, Gomes E, Rathod PK, Ferreira MU, Duraisingh MT. Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays. Antimicrob Agents Chemother. 2018 04; 62(4). PMID: 29378713.
    Citations: 1     Fields:    
  11. Patankar S, Sharma S, Rathod PK, Duraisingh MT. Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax. Proteomics Clin Appl. 2018 07; 12(4):e1700024. PMID: 29193853.
    Citations:    Fields:    
  12. Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 01 05; 359(6371):48-55. PMID: 29302006.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  13. Paul AS, Duraisingh MT. Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry. Trends Parasitol. 2018 02; 34(2):95-97. PMID: 29269028.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Dec 14; 171(7):1532-1544.e15. PMID: 29129376.
    Citations: 17     Fields:    Translation:HumansAnimals
  15. Lim C, Dankwa S, Paul AS, Duraisingh MT. Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination. Cold Spring Harb Perspect Med. 2017 Nov 01; 7(11). PMID: 28213436.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  16. Scully EJ, Kanjee U, Duraisingh MT. Molecular interactions governing host-specificity of blood stage malaria parasites. Curr Opin Microbiol. 2017 Dec; 40:21-31. PMID: 29096194.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Kanjee U, Grüring C, Chaand M, Lin KM, Egan E, Manzo J, Jones PL, Yu T, Barker R, Weekes MP, Duraisingh MT. CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9356-E9365. PMID: 29078358.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Dankwa S, Chaand M, Kanjee U, Jiang RHY, Nobre LV, Goldberg JM, Bei AK, Moechtar MA, Grüring C, Ahouidi AD, Ndiaye D, Dieye TN, Mboup S, Weekes MP, Duraisingh MT. Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes. Infect Immun. 2017 10; 85(10). PMID: 28760933.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT. The Molecular Basis of Erythrocyte Invasion by Malaria Parasites. Cell Host Microbe. 2017 Aug 09; 22(2):232-245. PMID: 28799908.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Bei AK, Ahouidi AD, Dvorin JD, Miura K, Diouf A, Ndiaye D, Premji Z, Diakite M, Mboup S, Long CA, Duraisingh MT. Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen. J Infect Dis. 2017 07 15; 216(2):267-275. PMID: 28605544.
    Citations:    Fields:    Translation:HumansAnimalsCells
  21. Kumar S, Kumar M, Ekka R, Dvorin JD, Paul AS, Madugundu AK, Gilberger T, Gowda H, Duraisingh MT, Keshava Prasad TS, Sharma P. PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum. Nat Commun. 2017 07 05; 8(1):63. PMID: 28680058.
    Citations: 6     Fields:    Translation:AnimalsCells
  22. Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT. Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Mar 06; 2:17038. PMID: 28263306.
    Citations:    Fields:    
  23. Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT. Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Feb 17; 2:17017. PMID: 28211852.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. Chery L, Maki JN, Mascarenhas A, Walke JT, Gawas P, Almeida A, Fernandes M, Vaz M, Ramanan R, Shirodkar D, Bernabeu M, Manoharan SK, Pereira L, Dash R, Sharma A, Shaik RB, Chakrabarti R, Babar P, White J, Mudeppa DG, Kumar S, Zuo W, Skillman KM, Kanjee U, Lim C, Shaw-Saliba K, Kumar A, Valecha N, Jindal VN, Khandeparkar A, Naik P, Amonkar S, Duraisingh MT, Tuljapurkar S, Smith JD, Dubhashi N, Pinto RG, Silveria M, Gomes E, Rathod PK. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malar J. 2016 11 25; 15(1):569. PMID: 27884146.
    Citations: 5     Fields:    
  25. Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, Rayner JC. Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications. PLoS Negl Trop Dis. 2016 Oct; 10(10):e0005091. PMID: 27798646.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Mantel PY, Hjelmqvist D, Walch M, Kharoubi-Hess S, Nilsson S, Ravel D, Ribeiro M, Grüring C, Ma S, Padmanabhan P, Trachtenberg A, Ankarklev J, Brancucci NM, Huttenhower C, Duraisingh MT, Ghiran I, Kuo WP, Filgueira L, Martinelli R, Marti M. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria. Nat Commun. 2016 10 10; 7:12727. PMID: 27721445.
    Citations: 23     Fields:    Translation:HumansCells
  27. Shaw-Saliba K, Thomson-Luque R, Obaldía N, Nuñez M, Dutary S, Lim C, Barnes S, Kocken CH, Duraisingh MT, Adams JH, Pasini EM. Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model. PLoS Negl Trop Dis. 2016 07; 10(7):e0004870. PMID: 27463518.
    Citations: 3     Fields:    Translation:AnimalsCells
  28. Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. Int J Parasitol. 2016 10; 46(11):679-83. PMID: 27456552.
    Citations: 1     Fields:    Translation:HumansAnimals
  29. Paul AS, Moreira CK, Elsworth B, Allred DR, Duraisingh MT. Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites. Antimicrob Agents Chemother. 2016 08; 60(8):5059-63. PMID: 27246780.
    Citations: 2     Fields:    Translation:Animals
  30. Kumar S, Mudeppa DG, Sharma A, Mascarenhas A, Dash R, Pereira L, Shaik RB, Maki JN, White J, Zuo W, Tuljapurkar S, Duraisingh MT, Gomes E, Chery L, Rathod PK. Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Mol Biochem Parasitol. 2016 Nov - Dec; 210(1-2):1-4. PMID: 27457272.
    Citations:    Fields:    Translation:HumansAnimals
  31. Lim C, Pereira L, Saliba KS, Mascarenhas A, Maki JN, Chery L, Gomes E, Rathod PK, Duraisingh MT. Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates. J Infect Dis. 2016 10 01; 214(7):1081-4. PMID: 27432121.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  32. Lim C, Pereira L, Shardul P, Mascarenhas A, Maki J, Rixon J, Shaw-Saliba K, White J, Silveira M, Gomes E, Chery L, Rathod PK, Duraisingh MT. Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia. Am J Hematol. 2016 08; 91(8):852-5. PMID: 27074559.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  33. Duraisingh MT, Horn D. Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa. Cell Host Microbe. 2016 May 11; 19(5):629-40. PMID: 27173931.
    Citations: 7     Fields:    Translation:HumansAnimals
  34. Dankwa S, Lim C, Bei AK, Jiang RH, Abshire JR, Patel SD, Goldberg JM, Moreno Y, Kono M, Niles JC, Duraisingh MT. Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite. Nat Commun. 2016 Apr 04; 7:11187. PMID: 27041489.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  35. Sidik SM, Hortua Triana MA, Paul AS, El Bakkouri M, Hackett CG, Tran F, Westwood NJ, Hui R, Zuercher WJ, Duraisingh MT, Moreno SN, Lourido S. Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling. J Biol Chem. 2016 Apr 29; 291(18):9566-80. PMID: 26933036.
    Citations: 7     Fields:    Translation:AnimalsCells
  36. Joice R, Frantzreb C, Pradham A, Seydel KB, Kamiza S, Wirth DF, Duraisingh MT, Molyneux ME, Taylor TE, Marti M, Milner DA. Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients. Mod Pathol. 2016 Apr; 29(4):381-90. PMID: 26916076.
    Citations: 3     Fields:    Translation:Humans
  37. Obaldía N, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti M. Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Sci Rep. 2016 Feb 16; 6:21216. PMID: 26880111.
    Citations: 1     Fields:    Translation:Animals
  38. Ahouidi AD, Amambua-Ngwa A, Awandare GA, Bei AK, Conway DJ, Diakite M, Duraisingh MT, Rayner JC, Zenonos ZA. Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN). Trends Parasitol. 2016 Apr; 32(4):274-283. PMID: 26725306.
    Citations:    Fields:    Translation:HumansAnimalsCells
  39. Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT. The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrob Agents Chemother. 2016 01; 60(1):613-6. PMID: 26459896.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  40. Assefa S, Lim C, Preston MD, Duffy CW, Nair MB, Adroub SA, Kadir KA, Goldberg JM, Neafsey DE, Divis P, Clark TG, Duraisingh MT, Conway DJ, Pain A, Singh B. Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13027-32. PMID: 26438871.
    Citations: 15     Fields:    Translation:Animals
  41. Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):42-56. PMID: 26259939.
    Citations: 23     Fields:    Translation:HumansAnimals
  42. Paul AS, Saha S, Engelberg K, Jiang RH, Coleman BI, Kosber AL, Chen CT, Ganter M, Espy N, Gilberger TW, Gubbels MJ, Duraisingh MT. Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans. Cell Host Microbe. 2015 Jul 08; 18(1):49-60. PMID: 26118996.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  43. Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT. Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science. 2015 May 08; 348(6235):711-4. PMID: 25954012.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  44. Paul AS, Egan ES, Duraisingh MT. Host-parasite interactions that guide red blood cell invasion by malaria parasites. Curr Opin Hematol. 2015 May; 22(3):220-6. PMID: 25767956.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  45. Merrick CJ, Jiang RH, Skillman KM, Samarakoon U, Moore RM, Dzikowski R, Ferdig MT, Duraisingh MT. Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. PLoS One. 2015; 10(3):e0118865. PMID: 25780929.
    Citations: 4     Fields:    Translation:Animals
  46. Choi JY, Duraisingh MT, Marti M, Ben Mamoun C, Voelker DR. From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE. J Biol Chem. 2015 Apr 24; 290(17):10972-80. PMID: 25724650.
    Citations: 7     Fields:    Translation:AnimalsCells
  47. Mejia P, Treviño-Villarreal JH, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh MT, Mitchell JR. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nat Commun. 2015 Jan 30; 6:6050. PMID: 25636003.
    Citations: 14     Fields:    Translation:AnimalsCells
  48. Bei AK, Duraisingh MT. Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry. Methods Mol Biol. 2015; 1325:167-86. PMID: 26450388.
    Citations:    Fields:    Translation:HumansAnimalsCells
  49. Kumar AA, Lim C, Moreno Y, Mace CR, Syed A, Van Tyne D, Wirth DF, Duraisingh MT, Whitesides GM. Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers. Am J Hematol. 2015 Jan; 90(1):31-6. PMID: 25263455.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  50. Coleman BI, Skillman KM, Jiang RHY, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BFC, Marti M, Llinás M, Buckee CO, Duraisingh MT. A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. Cell Host Microbe. 2014 Aug 13; 16(2):177-186. PMID: 25121747.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  51. Guillén N, Duraisingh M. Editorial overview: Host-microbe interactions: parasites: sensing and responding to the changing environment: the life of protozoan parasites. Curr Opin Microbiol. 2014 Aug; 20:vii-ix. PMID: 25081632.
    Citations:    Fields:    Translation:HumansAnimals
  52. Niang M, Bei AK, Madnani KG, Pelly S, Dankwa S, Kanjee U, Gunalan K, Amaladoss A, Yeo KP, Bob NS, Malleret B, Duraisingh MT, Preiser PR. STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting. Cell Host Microbe. 2014 Jul 09; 16(1):81-93. PMID: 25011110.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  53. Joice R, Nilsson SK, Montgomery J, Dankwa S, Egan E, Morahan B, Seydel KB, Bertuccini L, Alano P, Williamson KC, Duraisingh MT, Taylor TE, Milner DA, Marti M. Plasmodium falciparum transmission stages accumulate in the human bone marrow. Sci Transl Med. 2014 Jul 09; 6(244):244re5. PMID: 25009232.
    Citations: 50     Fields:    Translation:HumansAnimals
  54. Grüring C, Moon RW, Lim C, Holder AA, Blackman MJ, Duraisingh MT. Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol. 2014 May; 16(5):612-20. PMID: 24506567.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  55. Horn D, Duraisingh MT. Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol. 2014; 54:71-94. PMID: 24050701.
    Citations: 12     Fields:    Translation:Humans
  56. Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MT. Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. J Infect Dis. 2013 Nov 15; 208(10):1679-87. PMID: 23904294.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  57. Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh MT, Gilberger TW. Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum. Biochem J. 2013 Jun 15; 452(3):457-66. PMID: 23544851.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  58. Badiane AS, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr O, Ndir O, Tolia NH, Mboup S, Duraisingh MT. Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway. Clin Vaccine Immunol. 2013 Aug; 20(8):1238-45. PMID: 23761656.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  59. Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT. Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nat Commun. 2013; 4:1638. PMID: 23535659.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  60. Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe. 2012 Dec 13; 12(6):739-50. PMID: 23245319.
    Citations: 10     Fields:    Translation:AnimalsCells
  61. Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S. Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries. 2012 Oct 19; 6(10):727-33. PMID: 23103895.
    Citations: 2     Fields:    Translation:HumansAnimals
  62. Gubbels MJ, Duraisingh MT. Evolution of apicomplexan secretory organelles. Int J Parasitol. 2012 Nov; 42(12):1071-81. PMID: 23068912.
    Citations: 17     Fields:    Translation:AnimalsCells
  63. Vorobjev IA, Buchholz K, Prabhat P, Ketman K, Egan ES, Marti M, Duraisingh MT, Barteneva NS. Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malar J. 2012 Sep 05; 11:312. PMID: 22950515.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  64. Duraisingh MT, Lodish HF. Sickle cell microRNAs inhibit the malaria parasite. Cell Host Microbe. 2012 Aug 16; 12(2):127-8. PMID: 22901533.
    Citations: 2     Fields:    
  65. Bei AK, Duraisingh MT. Functional analysis of erythrocyte determinants of Plasmodium infection. Int J Parasitol. 2012 May 15; 42(6):575-82. PMID: 22726752.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  66. Merrick CJ, Huttenhower C, Buckee C, Amambua-Ngwa A, Gomez-Escobar N, Walther M, Conway DJ, Duraisingh MT. Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria. J Infect Dis. 2012 May 15; 205(10):1593-600. PMID: 22448008.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  67. Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod PK. Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop. 2012 Mar; 121(3):256-66. PMID: 22266213.
    Citations: 9     Fields:    Translation:HumansAnimalsPHPublic Health
  68. Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Ferguson DJ, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels MJ. A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 2012 Jan 13; 335(6065):218-21. PMID: 22246776.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  69. Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10. PMID: 22195562.
    Citations: 17     Fields:    Translation:AnimalsCells
  70. Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar; 121(3):175-83. PMID: 22142790.
    Citations: 6     Fields:    Translation:HumansAnimalsPHPublic Health
  71. Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop. 2012 Mar; 121(3):166-74. PMID: 22119584.
    Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
  72. Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature. 2011 Nov 09; 480(7378):534-7. PMID: 22080952.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  73. Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol. 2011 Jun 20; 12(6):R56. PMID: 21689454.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  74. Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Jun; 55(6):2612-22. PMID: 21422215.
    Citations: 9     Fields:    Translation:HumansAnimals
  75. Comeaux CA, Coleman BI, Bei AK, Whitehurst N, Duraisingh MT. Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth. Mol Microbiol. 2011 Apr; 80(2):378-90. PMID: 21320181.
    Citations: 20     Fields:    Translation:Animals
  76. Bei AK, Brugnara C, Duraisingh MT. In vitro genetic analysis of an erythrocyte determinant of malaria infection. J Infect Dis. 2010 Dec 01; 202(11):1722-7. PMID: 20958212.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  77. Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22; 285(43):33054-64. PMID: 20702404.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  78. Merrick CJ, Duraisingh MT. Epigenetics in Plasmodium: what do we really know? Eukaryot Cell. 2010 Aug; 9(8):1150-8. PMID: 20562224.
    Citations: 18     Fields:    Translation:HumansAnimals
  79. Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010 May 14; 328(5980):910-2. PMID: 20466936.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  80. Bei AK, Desimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT. A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol. 2010 Apr; 85(4):234-7. PMID: 20196166.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  81. Dvorin JD, Bei AK, Coleman BI, Duraisingh MT. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 Feb; 75(4):990-1006. PMID: 20487292.
    Citations: 13     Fields:    Translation:AnimalsCells
  82. Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 2010 Feb 26; 285(9):6857-66. PMID: 20042598.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  83. Ahouidi AD, Bei AK, Neafsey DE, Sarr O, Volkman S, Milner D, Cox-Singh J, Ferreira MU, Ndir O, Premji Z, Mboup S, Duraisingh MT. Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infect Genet Evol. 2010 Mar; 10(2):200-6. PMID: 19931645.
    Citations: 10     Fields:    Translation:HumansAnimals
  84. Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J. Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010 Feb; 9(2):228-41. PMID: 19783771.
    Citations: 29     Fields:    Translation:Animals
  85. Merrick CJ, Dzikowski R, Imamura H, Chuang J, Deitsch K, Duraisingh MT. The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. Int J Parasitol. 2010 Jan; 40(1):35-43. PMID: 19666023.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  86. DeSimone TM, Jennings CV, Bei AK, Comeaux C, Coleman BI, Refour P, Triglia T, Stubbs J, Cowman AF, Duraisingh MT. Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Mol Microbiol. 2009 May; 72(3):578-89. PMID: 19400777.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  87. Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009 Apr 23; 52(8):2185-7. PMID: 19317450.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  88. Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol. 2009 Apr 14; 7(4):e84. PMID: 19402747.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  89. Lantos PM, Ahouidi AD, Bei AK, Jennings CV, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology. 2009 Jan; 136(1):1-9. PMID: 19126266.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  90. Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):972-5. PMID: 19097788.
    Citations: 13     Fields:    Translation:AnimalsCells
  91. Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85. PMID: 18842591.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  92. DeSimone TM, Bei AK, Jennings CV, Duraisingh MT. Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. Int J Parasitol. 2009 Mar; 39(4):399-405. PMID: 18831976.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  93. Coleman BI, Duraisingh MT. Transcriptional control and gene silencing in Plasmodium falciparum. Cell Microbiol. 2008 Oct; 10(10):1935-46. PMID: 18637022.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  94. Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One. 2008 Feb 13; 3(2):e1570. PMID: 18270564.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  95. Duraisingh MT, DeSimone T, Jennings C, Refour P, Wu C. Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching. Subcell Biochem. 2008; 47:46-57. PMID: 18512340.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  96. Comeaux CA, Duraisingh MT. Unravelling a histone code for malaria virulence. Mol Microbiol. 2007 Dec; 66(6):1291-5. PMID: 18028316.
    Citations:    Fields:    Translation:AnimalsCells
  97. Militello KT, Refour P, Comeaux CA, Duraisingh MT. Antisense RNA and RNAi in protozoan parasites: working hard or hardly working? Mol Biochem Parasitol. 2008 Feb; 157(2):117-26. PMID: 18053590.
    Citations: 19     Fields:    Translation:Animals
  98. Merrick CJ, Duraisingh MT. Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryot Cell. 2007 Nov; 6(11):2081-91. PMID: 17827348.
    Citations: 29     Fields:    Translation:AnimalsCells
  99. Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg. 2007 Aug; 77(2):201-8. PMID: 17690387.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  100. Jennings CV, Ahouidi AD, Zilversmit M, Bei AK, Rayner J, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infect Immun. 2007 Jul; 75(7):3531-8. PMID: 17470537.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  101. Bei AK, Membi CD, Rayner JC, Mubi M, Ngasala B, Sultan AA, Premji Z, Duraisingh MT. Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania. Mol Biochem Parasitol. 2007 May; 153(1):66-71. PMID: 17303262.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  102. Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF. A genome-wide map of diversity in Plasmodium falciparum. Nat Genet. 2007 Jan; 39(1):113-9. PMID: 17159979.
    Citations: 130     Fields:    Translation:HumansAnimals
  103. Merrick CJ, Duraisingh MT. Heterochromatin-mediated control of virulence gene expression. Mol Microbiol. 2006 Nov; 62(3):612-20. PMID: 17076663.
    Citations: 22     Fields:    Translation:AnimalsCells
  104. Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep; 61(5):1187-95. PMID: 16925553.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  105. Duraisingh M, Ferdig MT, Stoeckert CJ, Volkman SK, McGovern VP. Plasmodium research in the postgenomic era. Trends Parasitol. 2006 Jan; 22(1):1-4. PMID: 16311071.
    Citations: 1     Fields:    Translation:HumansAnimals
  106. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science. 2005 Aug 26; 309(5739):1384-7. PMID: 16123303.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  107. Duraisingh MT, Refour P. Multiple drug resistance genes in malaria -- from epistasis to epidemiology. Mol Microbiol. 2005 Aug; 57(4):874-7. PMID: 16091030.
    Citations: 13     Fields:    Translation:HumansAnimals
  108. Duraisingh MT, Cowman AF. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 2005 Jun; 94(3):181-90. PMID: 15876420.
    Citations: 95     Fields:    Translation:HumansAnimals
  109. Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, Thompson JK, Freitas-Junior LH, Scherf A, Crabb BS, Cowman AF. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 2005 Apr 08; 121(1):13-24. PMID: 15820675.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  110. Triglia T, Duraisingh MT, Good RT, Cowman AF. Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol. 2005 Jan; 55(1):162-74. PMID: 15612925.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  111. Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4796-801. PMID: 12672957.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  112. Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, McFadden GI, Cowman AF. Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J. 2003 Mar 03; 22(5):1047-57. PMID: 12606570.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  113. Ngo T, Duraisingh M, Reed M, Hipgrave D, Biggs B, Cowman AF. Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin. Am J Trop Med Hyg. 2003 Mar; 68(3):350-6. PMID: 12685644.
    Citations: 24     Fields:    Translation:Animals
  114. Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, Cowman AF. A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem. 2003 Apr 18; 278(16):14480-6. PMID: 12556470.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  115. Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF. Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med. 2003 Jan; 9(1):87-92. PMID: 12469115.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  116. Sutherland CJ, Alloueche A, Curtis J, Drakeley CJ, Ord R, Duraisingh M, Greenwood BM, Pinder M, Warhurst D, Targett GA. Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes. Am J Trop Med Hyg. 2002 Dec; 67(6):578-85. PMID: 12518847.
    Citations: 39     Fields:    Translation:HumansAnimals
  117. Baldi DL, Good R, Duraisingh MT, Crabb BS, Cowman AF. Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infect Immun. 2002 Sep; 70(9):5236-45. PMID: 12183575.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  118. Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, Upcroft P. Resistance to antiparasitic drugs: the role of molecular diagnosis. Int J Parasitol. 2002 May; 32(5):637-53. PMID: 11943235.
    Citations: 10     Fields:    Translation:HumansAnimals
  119. O'Donnell RA, Freitas-Junior LH, Preiser PR, Williamson DH, Duraisingh M, McElwain TF, Scherf A, Cowman AF, Crabb BS. A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J. 2002 Mar 01; 21(5):1231-9. PMID: 11867551.
    Citations: 43     Fields:    Translation:AnimalsCells
  120. Cowman AF, Baldi DL, Duraisingh M, Healer J, Mills KE, O'Donnell RA, Thompson J, Triglia T, Wickham ME, Crabb BS. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):25-33. PMID: 11839179.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  121. Duraisingh MT, Triglia T, Cowman AF. Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol. 2002 Jan; 32(1):81-9. PMID: 11796125.
    Citations: 72     Fields:    Translation:Animals
  122. Warhurst DC, Duraisingh MT. Rational use of drugs against Plasmodium falciparum. Trans R Soc Trop Med Hyg. 2001 Jul-Aug; 95(4):345-6. PMID: 11579870.
    Citations: 3     Fields:    Translation:HumansAnimals
  123. Cowman AF, Duraisingh MT. An old enemy, a new battle plan. Perspective on combating drug-resistant malaria. EMBO Rep. 2001 Feb; 2(2):77-9. PMID: 11258713.
    Citations: 1     Fields:    Translation:HumansAnimals
  124. Duraisingh MT, von Seidlein LV, Jepson A, Jones P, Sambou I, Pinder M, Warhurst DC. Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum. Parasitology. 2000 Jul; 121 ( Pt 1):1-7. PMID: 11085219.
    Citations: 21     Fields:    Translation:HumansAnimals
  125. Duraisingh MT, Roper C, Walliker D, Warhurst DC. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol. 2000 May; 36(4):955-61. PMID: 10844681.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  126. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol. 2000 Apr 30; 108(1):13-23. PMID: 10802315.
    Citations: 115     Fields:    Translation:HumansAnimals
  127. von Seidlein L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P, Doherty T. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 2000 Jan 29; 355(9201):352-7. PMID: 10665554.
    Citations: 37     Fields:    Translation:HumansAnimalsCTClinical Trials
  128. Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother. 1999 Dec; 43(12):2943-9. PMID: 10582887.
    Citations: 103     Fields:    Translation:HumansAnimals
  129. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study. Parasitology. 1999 Nov; 119 ( Pt 5):435-40. PMID: 10599075.
    Citations: 8     Fields:    Translation:HumansAnimals
  130. Jelinek T, Kilian AH, Curtis J, Duraisingh MT, Kabagambe G, von Sonnenburg F, Warhurst DC. Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children. Am J Trop Med Hyg. 1999 Jul; 61(1):125-30. PMID: 10432069.
    Citations: 12     Fields:    Translation:HumansAnimals
  131. Jelinek T, Rønn AM, Lemnge MM, Curtis J, Mhina J, Duraisingh MT, Bygbjerg IC, Warhurst DC. Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania. Trop Med Int Health. 1998 Aug; 3(8):605-9. PMID: 9735930.
    Citations: 19     Fields:    Translation:HumansAnimals
  132. Curtis J, Duraisingh MT, Warhurst DC. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. J Infect Dis. 1998 May; 177(5):1429-33. PMID: 9593041.
    Citations: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  133. Duraisingh MT, Curtis J, Warhurst DC. Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol. 1998 May; 89(1):1-8. PMID: 9603482.
    Citations: 91     Fields:    Translation:Animals
  134. Jelinek T, Rønn AM, Curtis J, Duraisingh MT, Lemnge MM, Mhina J, Bygbjerg IC, Warhurst DC. High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance. Trop Med Int Health. 1997 Nov; 2(11):1075-9. PMID: 9391510.
    Citations: 4     Fields:    Translation:HumansAnimals
  135. von Seidlein L, Duraisingh MT, Drakeley CJ, Bailey R, Greenwood BM, Pinder M. Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia. Trans R Soc Trop Med Hyg. 1997 Jul-Aug; 91(4):450-3. PMID: 9373652.
    Citations: 11     Fields:    Translation:HumansAnimals
  136. Duraisingh MT, Drakeley CJ, Muller O, Bailey R, Snounou G, Targett GA, Greenwood BM, Warhurst DC. Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology. 1997 Mar; 114 ( Pt 3):205-11. PMID: 9075340.
    Citations: 42     Fields:    Translation:HumansAnimalsCTClinical Trials
  137. Curtis J, Duraisingh MT, Trigg JK, Mbwana H, Warhurst DC, Curtis CF. Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania. Trans R Soc Trop Med Hyg. 1996 Nov-Dec; 90(6):678-80. PMID: 9015515.
    Citations: 6     Fields:    Translation:HumansAnimals
  138. Drakeley CJ, Duraisingh MT, Póvoa M, Conway DJ, Targett GA, Baker DA. Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate. Mol Biochem Parasitol. 1996 Oct 30; 81(2):253-7. PMID: 8898341.
    Citations: 5     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.