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Albert Edge, PH.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lopez-Juarez A, Lahlou H, Ripoll C, Cazals Y, Brezun JM, Wang Q, Edge A, Zine A. Engraftment of Human Stem Cell-Derived Otic Progenitors in the Damaged Cochlea. Mol Ther. 2019 Apr 02. PMID: 31005598.
    Citations:    
  2. Lenz DR, Gunewardene N, Abdul-Aziz DE, Wang Q, Gibson TM, Edge ASB. Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation. Front Cell Dev Biol. 2019; 7:14. PMID: 30873406.
    Citations:    
  3. Samarajeewa A, Lenz DR, Xie L, Chiang H, Kirchner R, Mulvaney JF, Edge ASB, Dabdoub A. Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea. Development. 2018 11 27; 145(23). PMID: 30389848.
    Citations:    Fields:    
  4. Zhang J, Wang Q, Abdul-Aziz D, Mattiacio J, Edge ASB, White PM. ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea. Eur J Neurosci. 2018 Nov; 48(10):3299-3316. PMID: 30270571.
    Citations:    Fields:    
  5. Yeh WH, Chiang H, Rees HA, Edge ASB, Liu DR. In vivo base editing of post-mitotic sensory cells. Nat Commun. 2018 06 05; 9(1):2184. PMID: 29872041.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Kempfle JS, Nguyen K, Hamadani C, Koen N, Edge AS, Kashemirov BA, Jung DH, McKenna CE. Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss. Bioconjug Chem. 2018 04 18; 29(4):1240-1250. PMID: 29485861.
    Citations:    Fields:    
  7. Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton RA, Babina M, Baillie JK, Barnett TC, Beckhouse AG, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle AJ, Clevers HC, Davis CA, Detmar M, Dohi T, Edge ASB, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Fagiolini M, Fairbairn L, Farach-Carson MC, Faulkner GJ, Ferrai C, Fisher ME, Forrester LM, Fujita R, Furusawa JI, Geijtenbeek TB, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heutink P, Hitchens KJ, Hume DA, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura YI, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken SP, Knox AJ, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris KJ, Motohashi H, Mummery CL, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin XY, Rehli M, Rizzu P, Roy S, Sajantila A, Sakaguchi S, Sato H, Satoh H, Savvi S, Saxena A, Schmidl C, Schneider C, Schulze-Tanzil GG, Schwegmann A, Sheng G, Shin JW, Sugiyama D, Sugiyama T, Summers KM, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyoda H, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Wells CA, Winteringham LN, Wolvetang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang PG, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin S, Sengstag T, Severin J, Shimoji H, Suzuki M, Suzuki H, Kawai J, Kondo N, Itoh M, Daub CO, Kasukawa T, Kawaji H, Carninci P, Forrest ARR, Hayashizaki Y. FANTOM5 CAGE profiles of human and mouse samples. Sci Data. 2017 08 29; 4:170112. PMID: 28850106.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat Commun. 2017 06 06; 8:15790. PMID: 28585549.
    Citations: 19     Fields:    Translation:AnimalsCells
  9. Kempfle JS, Fiorillo B, Kanumuri VV, Barber S, Edge ASB, Cunnane M, Remenschneider AK, Lee DJ, Kozin ED. Quantitative imaging analysis of transcanal endoscopic Infracochlear approach to the internal auditory canal. Am J Otolaryngol. 2017 Sep - Oct; 38(5):518-520. PMID: 28687426.
    Citations: 1     Fields:    Translation:Humans
  10. McLean WJ, Yin X, Lu L, Lenz DR, McLean D, Langer R, Karp JM, Edge ASB. Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. Cell Rep. 2017 02 21; 18(8):1917-1929. PMID: 28228258.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. McLean WJ, McLean DT, Eatock RA, Edge AS. Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs. Development. 2016 12 01; 143(23):4381-4393. PMID: 27789624.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Hu L, Lu J, Chiang H, Wu H, Edge AS, Shi F. Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice. J Neurosci. 2016 09 07; 36(36):9479-89. PMID: 27605621.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Cheng YF, Tong M, Edge AS. Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development. J Biol Chem. 2016 Sep 30; 291(40):21096-21109. PMID: 27542412.
    Citations: 2     Fields:    Translation:HumansCells
  14. Kempfle JS, Turban JL, Edge AS. Sox2 in the differentiation of cochlear progenitor cells. Sci Rep. 2016 Mar 18; 6:23293. PMID: 26988140.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Kempfle J, Kozin ED, Remenschneider AK, Eckhard A, Edge A, Lee DJ. Endoscopic Transcanal Retrocochlear Approach to the Internal Auditory Canal with Cochlear Preservation: Pilot Cadaveric Study. Otolaryngol Head Neck Surg. 2016 05; 154(5):920-923. PMID: 26932951.
    Citations: 1     Fields:    Translation:Humans
  16. Geng R, Noda T, Mulvaney JF, Lin VY, Edge AS, Dabdoub A. Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. PLoS One. 2016; 11(2):e0148339. PMID: 26859490.
    Citations: 6     Fields:    Translation:AnimalsCells
  17. Chambers AR, Resnik J, Yuan Y, Whitton JP, Edge AS, Liberman MC, Polley DB. Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation. Neuron. 2016 Feb 17; 89(4):867-79. PMID: 26833137.
    Citations: 23     Fields:    Translation:AnimalsCells
  18. Fujioka M, Okano H, Edge AS. Manipulating cell fate in the cochlea: a feasible therapy for hearing loss. Trends Neurosci. 2015 Mar; 38(3):139-44. PMID: 25593106.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  19. Darrow KN, Slama MC, Kozin ED, Owoc M, Hancock K, Kempfle J, Edge A, Lacour S, Boyden E, Polley D, Brown MC, Lee DJ. Optogenetic stimulation of the cochlear nucleus using channelrhodopsin-2 evokes activity in the central auditory pathways. Brain Res. 2015 Mar 02; 1599:44-56. PMID: 25481416.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Diensthuber M, Zecha V, Wagenblast J, Arnhold S, Edge AS, Stöver T. Spiral ganglion stem cells can be propagated and differentiated into neurons and glia. Biores Open Access. 2014 Jun 01; 3(3):88-97. PMID: 24940560.
    Citations: 13     
  21. Shi F, Hu L, Jacques BE, Mulvaney JF, Dabdoub A, Edge AS. ß-Catenin is required for hair-cell differentiation in the cochlea. J Neurosci. 2014 May 07; 34(19):6470-9. PMID: 24806673.
    Citations: 33     Fields:    Translation:AnimalsCells
  22. Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furino M, Furusawa J, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JF, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-Sim A, Manabe R, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Noma S, Noazaki T, Ogishima S, Ohkura N, Ohimiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JG, Rackham OJ, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, 't Hoen PA, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyodo H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verado R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y. A promoter-level mammalian expression atlas. Nature. 2014 Mar 27; 507(7493):462-70. PMID: 24670764.
    Citations: 447     Fields:    Translation:HumansAnimalsCells
  23. Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F, Forrest ARR, Carninci P, Rehli M, Sandelin A. An atlas of active enhancers across human cell types and tissues. Nature. 2014 Mar 27; 507(7493):455-461. PMID: 24670763.
    Citations: 503     Fields:    Translation:HumansCells
  24. Bramhall NF, Shi F, Arnold K, Hochedlinger K, Edge AS. Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. Stem Cell Reports. 2014 Mar 11; 2(3):311-22. PMID: 24672754.
    Citations: 48     Fields:    Translation:AnimalsCells
  25. Brugeaud A, Tong M, Luo L, Edge AS. Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells. Dev Neurobiol. 2014 Apr; 74(4):457-66. PMID: 24123853.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Parker MA, Cheng YF, Kinouchi H, Bieber R, Edge AS. An independent construct for conditional expression of atonal homolog-1. Hum Gene Ther Methods. 2014 Feb; 25(1):1-13. PMID: 24066662.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  27. Yuan Y, Shi F, Yin Y, Tong M, Lang H, Polley DB, Liberman MC, Edge AS. Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy. J Assoc Res Otolaryngol. 2014 Feb; 15(1):31-43. PMID: 24113829.
    Citations: 33     Fields:    Translation:AnimalsCells
  28. Shi F, Hu L, Edge AS. Generation of hair cells in neonatal mice by ß-catenin overexpression in Lgr5-positive cochlear progenitors. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13851-6. PMID: 23918377.
    Citations: 59     Fields:    Translation:AnimalsCells
  29. Kao SY, Kempfle JS, Jensen JB, Perez-Fernandez D, Lysaght AC, Edge AS, Stankovic KM. Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss. Neurobiol Dis. 2013 Aug; 56:25-33. PMID: 23607938.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Tong M, Brugeaud A, Edge AS. Regenerated synapses between postnatal hair cells and auditory neurons. J Assoc Res Otolaryngol. 2013 Jun; 14(3):321-9. PMID: 23423560.
    Citations: 16     Fields:    Translation:AnimalsCells
  31. Shi F, Edge AS. Prospects for replacement of auditory neurons by stem cells. Hear Res. 2013 Mar; 297:106-12. PMID: 23370457.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  32. Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS. Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron. 2013 Jan 09; 77(1):58-69. PMID: 23312516.
    Citations: 106     Fields:    Translation:AnimalsCells
  33. Nayagam BA, Edge AS, Needham K, Hyakumura T, Leung J, Nayagam DA, Dottori M. An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants. Stem Cells Dev. 2013 Mar 15; 22(6):901-12. PMID: 23078657.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  34. Shi F, Kempfle JS, Edge AS. Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. J Neurosci. 2012 Jul 11; 32(28):9639-48. PMID: 22787049.
    Citations: 81     Fields:    Translation:AnimalsCells
  35. Jeon SJ, Fujioka M, Kim SC, Edge AS. Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells. J Neurosci. 2011 Jun 08; 31(23):8351-8. PMID: 21653840.
    Citations: 43     Fields:    Translation:AnimalsCells
  36. Fujioka M, Tokano H, Fujioka KS, Okano H, Edge AS. Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation. J Clin Invest. 2011 Jun; 121(6):2462-9. PMID: 21576819.
    Citations: 9     Fields:    Translation:AnimalsCells
  37. Parker MA, Jiang K, Kempfle JS, Mizutari K, Simmons CL, Bieber R, Adams J, Edge AS. TAK1 expression in the cochlea: a specific marker for adult supporting cells. J Assoc Res Otolaryngol. 2011 Aug; 12(4):471-83. PMID: 21472480.
    Citations: 5     Fields:    Translation:AnimalsCells
  38. Parker M, Brugeaud A, Edge AS. Primary culture and plasmid electroporation of the murine organ of Corti. J Vis Exp. 2010 Feb 04; (36). PMID: 20134402.
    Citations: 19     Fields:    Translation:Animals
  39. Shi F, Cheng YF, Wang XL, Edge AS. Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhancer. J Biol Chem. 2010 Jan 01; 285(1):392-400. PMID: 19864427.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  40. Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. BMC Neurosci. 2009 Sep 24; 10:122. PMID: 19778451.
    Citations: 9     Fields:    Translation:AnimalsCells
  41. Edge AS, Chen ZY. Hair cell regeneration. Curr Opin Neurobiol. 2008 Aug; 18(4):377-82. PMID: 18929656.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  42. Martinez-Monedero R, Yi E, Oshima K, Glowatzki E, Edge AS. Differentiation of inner ear stem cells to functional sensory neurons. Dev Neurobiol. 2008 Apr; 68(5):669-84. PMID: 18278797.
    Citations: 42     Fields:    Translation:AnimalsCells
  43. Shi F, Corrales CE, Liberman MC, Edge AS. BMP4 induction of sensory neurons from human embryonic stem cells and reinnervation of sensory epithelium. Eur J Neurosci. 2007 Dec; 26(11):3016-23. PMID: 18005071.
    Citations: 34     Fields:    Translation:HumansCells
  44. Martinez-Monedero R, Oshima K, Heller S, Edge AS. The potential role of endogenous stem cells in regeneration of the inner ear. Hear Res. 2007 May; 227(1-2):48-52. PMID: 17321086.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  45. Martinez-Monedero R, Edge AS. Stem cells for the replacement of inner ear neurons and hair cells. Int J Dev Biol. 2007; 51(6-7):655-61. PMID: 17891724.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  46. Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. J Assoc Res Otolaryngol. 2007 Mar; 8(1):18-31. PMID: 17171473.
    Citations: 109     Fields:    Translation:AnimalsCells
  47. Jeon SJ, Oshima K, Heller S, Edge AS. Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Mol Cell Neurosci. 2007 Jan; 34(1):59-68. PMID: 17113786.
    Citations: 31     Fields:    Translation:AnimalsCells
  48. Corrales CE, Pan L, Li H, Liberman MC, Heller S, Edge AS. Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti. J Neurobiol. 2006 Nov; 66(13):1489-500. PMID: 17013931.
    Citations: 55     Fields:    Translation:AnimalsCells
  49. Huang L, Shimaoka M, Rondon IJ, Roy I, Chang Q, Po M, Dransfield DT, Ladner RC, Edge AS, Salas A, Wood CR, Springer TA, Cohen EH. Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. J Leukoc Biol. 2006 Oct; 80(4):905-14. PMID: 16888085.
    Citations: 8     Fields:    Translation:HumansCells
  50. Martinez-Monedero R, Corrales CE, Cuajungco MP, Heller S, Edge AS. Reinnervation of hair cells by auditory neurons after selective removal of spiral ganglion neurons. J Neurobiol. 2006 Mar; 66(4):319-31. PMID: 16408287.
    Citations: 31     Fields:    Translation:AnimalsCells
  51. Li H, Corrales CE, Edge A, Heller S. Stem cells as therapy for hearing loss. Trends Mol Med. 2004 Jul; 10(7):309-15. PMID: 15242678.
    Citations: 25     Fields:    Translation:HumansCells
  52. Crosby K, Yatko C, Dersimonian H, Pan L, Edge AS. A novel monoclonal antibody inhibits the immune response of human cells against porcine cells: identification of a porcine antigen homologous to CD58. Transplantation. 2004 Apr 27; 77(8):1288-94. PMID: 15114100.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  53. Edge AS. Deglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function. Biochem J. 2003 Dec 01; 376(Pt 2):339-50. PMID: 12974674.
    Citations: 27     Fields:    Translation:Cells
  54. Nagata H, Ito M, Shirota C, Edge A, McCowan TC, Fox IJ. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. Transplantation. 2003 Aug 27; 76(4):732-4. PMID: 12973119.
    Citations: 16     Fields:    Translation:AnimalsCells
  55. Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge AS, Jacoby DB, Dinsmore JH, Wright S, Aretz TH, Eisen HJ, Aaronson KD. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol. 2003 Mar 05; 41(5):879-88. PMID: 12628737.
    Citations: 89     Fields:    Translation:HumansCellsCTClinical Trials
  56. Del Priore LV, Sheng Y, Johnson E, Jacoby D, Edge A, Suzuki T, Geng L, Tezel TH, Kaplan HJ. Identification of transplanted retinal pigment epithelium with a novel chromosomal marker. Curr Eye Res. 2003 Feb; 26(2):125-31. PMID: 12815532.
    Citations:    Fields:    Translation:AnimalsCells
  57. Nagata H, Ito M, Cai J, Edge AS, Platt JL, Fox IJ. Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation. Gastroenterology. 2003 Feb; 124(2):422-31. PMID: 12557148.
    Citations: 21     Fields:    Translation:AnimalsCells
  58. Nagata H, Ito M, Shirota C, Edge ASB, McCowan TC, Fox IJ. Transplantation. Route of hepatocyte delivery affects hepatocyte engraftment in the spleen. 2003; 76:732-734.
  59. Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, Zawadzka A, Wetzel K, Sawyer DB, Colucci WS, Apstein CS, Liao R. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation. 2001 Apr 10; 103(14):1920-7. PMID: 11294813.
    Citations: 42     Fields:    Translation:Animals
  60. Edge ASB. Graft. Xenotransplantation of neural cells. 2001; 4:118-119.
  61. Edge AS, Spiro RG. A specific structural alteration in the heparan sulphate of human glomerular basement membrane in diabetes. Diabetologia. 2000 Aug; 43(8):1056-9. PMID: 10990084.
    Citations: 4     Fields:    Translation:Humans
  62. Edge AS. Current applications of cellular xenografts. Transplant Proc. 2000 Aug; 32(5):1169-71. PMID: 10936405.
    Citations: 6     Fields:    Translation:HumansAnimals
  63. Stefan AM, Coulter S, Gray B, LaMorte W, Nikelaeson S, Edge AS, Afdhal NH. Xenogeneic transplantation of porcine hepatocytes into the CCl4 cirrhotic rat model. Cell Transplant. 1999 Nov-Dec; 8(6):649-59. PMID: 10701494.
    Citations: 2     Fields:    Translation:Animals
  64. DerSimonian H, Pan L, Yatko C, Rodrigue-Way A, Johnson E, Edge AS. Human anti-porcine T cell response: blocking with anti-class I antibody leads to hyporesponsiveness and a switch in cytokine production. J Immunol. 1999 Jun 15; 162(12):6993-7001. PMID: 10358140.
    Citations:    Fields:    Translation:HumansAnimalsCells
  65. Edge AS, Gosse ME, Dinsmore J. Xenogeneic cell therapy: current progress and future developments in porcine cell transplantation. Cell Transplant. 1998 Nov-Dec; 7(6):525-39. PMID: 9853581.
    Citations: 9     Fields:    Translation:HumansAnimals
  66. Sullivan JA, Oettinger HF, Sachs DH, Edge AS. Analysis of polymorphism in porcine MHC class I genes: alterations in signals recognized by human cytotoxic lymphocytes. J Immunol. 1997 Sep 01; 159(5):2318-26. PMID: 9278321.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  67. Edge AS, Spiro RG. Structure of the O-linked oligosaccharides from a major thyroid cell surface glycoprotein. Arch Biochem Biophys. 1997 Jul 01; 343(1):73-80. PMID: 9210648.
    Citations: 3     Fields:    Translation:Cells
  68. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med. 1997 Mar; 3(3):350-3. PMID: 9055867.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  69. Gunsalus JR, Coulter SM, Gray BM, Edge AS. Xenotransplantation for the treatment of hypercholesterolemia. Transplant Proc. 1997 Feb-Mar; 29(1-2):905-6. PMID: 9123581.
    Citations:    Fields:    Translation:Animals
  70. Donnelly CE, Yatko C, Johnson EW, Edge AS. Human natural killer cells account for non-MHC class I-restricted cytolysis of porcine cells. Cell Immunol. 1997 Feb 01; 175(2):171-8. PMID: 9023423.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  71. Oettinger HF, Sullivan JA, Horvath KE, Kelley JA, Jacoby DB, Dinsmore J, Zawadska A, Edge ASB. Xenotransplantation. Species-specific detection of porcine xenografts with an antibody against a novel epitope of the lymphocyte homing receptor CD44. 1997; 4:252-261.
  72. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge AS. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med. 1997 Jan; 3(1):48-53. PMID: 8986740.
    Citations: 12     Fields:    Translation:Animals
  73. Edge ASB, DInsmore J. Xeno. Xenotransplantation in the central nervous system. 1997; 5:23-25.
  74. LaVecchio JA, Dunne AD, Edge AS. Enzymatic removal of alpha-galactosyl epitopes from porcine endothelial cells diminishes the cytotoxic effect of natural antibodies. Transplantation. 1995 Oct 27; 60(8):841-7. PMID: 7482745.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  75. Oettinger HF, Rodrigue-Way A, Bousquet JJ, Edge AS. Porcine repeat element DNA: in situ detection of xenotransplanted cells. Cell Transplant. 1995 Mar-Apr; 4(2):253-6. PMID: 7773559.
    Citations:    Fields:    Translation:HumansAnimalsCells
  76. Edge AS, Karasik A, Yamada K, Kahn CR. Effect of dexamethasone on the carbohydrate chains of the insulin receptor. Biochem Biophys Res Commun. 1994 Apr 29; 200(2):852-9. PMID: 8179619.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  77. Edge AS, Kahn CR, Spiro RG. Insulin receptor carbohydrate units contain poly-N-acetyllactosamine chains. Endocrinology. 1990 Oct; 127(4):1887-95. PMID: 2119296.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  78. Edge AS, Spiro RG. Characterization of novel sequences containing 3-O-sulfated glucosamine in glomerular basement membrane heparan sulfate and localization of sulfated disaccharides to a peripheral domain. J Biol Chem. 1990 Sep 15; 265(26):15874-81. PMID: 2144291.
    Citations: 12     Fields:    Translation:AnimalsCells
  79. Edge AS, Spiro RG. Presence of an O-glycosidically linked hexasaccharide in fetuin. J Biol Chem. 1987 Nov 25; 262(33):16135-41. PMID: 2445744.
    Citations: 20     Fields:    Translation:AnimalsCells
  80. Edge AS, Spiro RG. Selective deglycosylation of the heparan sulfate proteoglycan of bovine glomerular basement membrane and identification of the core protein. J Biol Chem. 1987 May 15; 262(14):6893-8. PMID: 2952658.
    Citations: 8     Fields:    Translation:Animals
  81. Edge AS, Van Langenhove A, Reinhold V, Weber P. Characterization of O-glycosidically linked oligosaccharides of rat erythrocyte membrane sialoglycoproteins. Biochemistry. 1986 Dec 02; 25(24):8017-24. PMID: 3801456.
    Citations: 1     Fields:    Translation:AnimalsCells
  82. Edge AS, Spiro RG. Thyroid cell surface glycoproteins. Nature and disposition of carbohydrate units and evaluation of their blood group I activity. J Biol Chem. 1985 Dec 05; 260(28):15332-8. PMID: 4066673.
    Citations: 6     Fields:    Translation:AnimalsCells
  83. Edge AS, Spiro RG. Structural elucidation of glycosaminoglycans through characterization of disaccharides obtained after fragmentation by hydrazine-nitrous acid treatment. Arch Biochem Biophys. 1985 Aug 01; 240(2):560-72. PMID: 3927841.
    Citations: 6     Fields:    Translation:HumansAnimals
  84. Herzberg VL, Grigorescu F, Edge AS, Spiro RG, Kahn CR. Characterization of insulin receptor carbohydrate by comparison of chemical and enzymatic deglycosylation. Biochem Biophys Res Commun. 1985 Jun 28; 129(3):789-96. PMID: 2990467.
    Citations: 10     Fields:    Translation:HumansCells
  85. Edge AS, Spiro RG. Presence of sulfate in N-glycosidically linked carbohydrate units of calf thyroid plasma membrane glycoproteins. J Biol Chem. 1984 Apr 25; 259(8):4710-3. PMID: 6715317.
    Citations: 8     Fields:    Translation:AnimalsCells
  86. Edge AS, Weber P. Isolation of sulfited oligosaccharides from glycoproteins treated with alkaline sulfite. Carbohydr Res. 1984 Mar 15; 126(2):279-85. PMID: 6201272.
    Citations:    Fields:    Translation:AnimalsCells
  87. Edge AS, Faltynek CR, Hof L, Reichert LE, Weber P. Deglycosylation of glycoproteins by trifluoromethanesulfonic acid. Anal Biochem. 1981 Nov 15; 118(1):131-7. PMID: 6175244.
    Citations: 184     Fields:    Translation:HumansAnimals
  88. Edge AS, Weber P. Purification and characterization of the major sialoglycoproteins of the rat erythrocyte membrane. Arch Biochem Biophys. 1981 Jul; 209(2):697-705. PMID: 7294819.
    Citations: 1     Fields:    Translation:AnimalsCells
  89. Edge AS, Weber P. Cleavage of dehydroalanine-containing peptides with mercuric acetate. Int J Pept Protein Res. 1981 Jul; 18(1):1-5. PMID: 7309364.
    Citations:    Fields:    
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.