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Martin Russell Pollak, M.D.

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Overview
We are working to identify genes involved in the development of focal segmental glomerulosclerosis (FSGS). FSGS is a common form of renal disease, seen both as an isolated entity and as a consequence of other primary processes. Towards this goal, blood for DNA extraction and clinical analyses have been performed on members of approximately 125 families with an inherited form of this condition, as well as over a hundred sporadic cases. We identified the first FSGS locus on chromosome 19q13. We have recently found mutations in ACTN4, encoding alpha-actinin-4, as the cause of disease in FSGS-1 linked families. Because FSGS is also a cause of renal dysfunction secondary to multiple other diseases, we are examining the role of this FSGS gene as a candidate renal dysfunction susceptibility gene. Current efforts are also underway to understand the function of ACTN4 and the mechanism of this form of kidney disease. We have developed “knockout” and “knockin” mouse models. We are working to identify additional human FSGS genes by genetic linkage and candidate gene approaches.

A second major focus of study is the extracellular calcium receptor. Previously, I cloned the human calcium-sensing receptor (CaR) gene and demonstrated that CaR defects cause three distinct disorders of extracellular calcium homeostasis. Our current work utilizes mouse models to further define the role of CaR. Mating mice heterozygous CaR "knockout" mice with mice with a targeted disruption of the preproPTH gene generates mice with both mutations. Mice homozygous for both "knockout" alleles, unlike the CaR-deficient mice, are viable because they will be incapable of developing the otherwise lethal hypercalcemia characteristic of CaR-deficient mice. We are using these mice to study the role of CaR in the intestine, in the kidney, as well as in the brain and bone marrow. In addition, we are using Cre/Lox technology to develop tools to allow tissue specific inactivation of CaR.

Mentoring
Available: 09/03/12, Expires: 08/31/20

Our laboratory has a major interest in understanding the basis of the large racial disparity in rates of kidney disease between people of recent African ancestry and other groups. We have found that this is due almost entirely to changes in a gene called APOL1. We are pursuing further studies of this at many levels: the development of animal models, additional human genetic studies, biochemistry, and clinical studies. There are opportunities for interested students in many of these areas.

Available: 06/01/17, Expires: 07/01/22

There are several general areas of study within my laboratory that provide potential projects for students: 1.We recently showed that variants in the APOL1 gene account for the large disparity in the rates of kidney disease between people of recent African ancestry and other groups. There are potential projects to help better understand this at many levels: genetic testing in humans; social and ethical implications; cell biologic studies to understand disease mechanism; development of animal models. 2. We do family based genetic studies to look for new genes involved in the etiology of kidney disease. These include studies of diseases of the glomerulus and disorders of kidney development. 3. We are using mouse models to explore the role of several human disease genes, including APOL1, INF2, ACTN4, and CASR. Students could play a role in any of these studies.

FSGS-associated mutations in TRPC6 potentially disrupt membrane turnover of the channel by the multivesicular body degradation pathway
Part Time, 10/28/08 - 06/12/09

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MD007898 (POLLAK, MARTIN R.) Jul 3, 2013 - Jan 31, 2018
    NIH/NIMHD
    Molecular Mechanism of APOL1 Associated Kidney Disease
    Role: Co-Principal Investigator
  2. R01MD007092 (POLLAK, MARTIN R.) Apr 1, 2012 - Jan 31, 2022
    NIH/NIMHD
    APOL1 variants: Understanding the basis of disparities in rates of kidney disease
    Role: Principal Investigator
  3. R24DK092158 (POLLAK, MARTIN R.) Sep 19, 2011 - Aug 31, 2013
    NIH/NIDDK
    Clinical characterization of the APOL1-associated phenotype
    Role: Co-Principal Investigator
  4. R01DK083592 (MILLER, RICHARD TYLER) Sep 30, 2010 - Jul 31, 2014
    NIH/NIDDK
    Biophysical Properties of Renal Glomeruli and Podocytes
    Role: Co-Principal Investigator
  5. R01DK088826 (POLLAK, MARTIN R.) Jul 15, 2010 - Nov 30, 2018
    NIH/NIDDK
    Biological Mechanism of INF2-mediated FSGS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chun J, Zhang JY, Wilkins MS, Subramanian B, Riella C, Magraner JM, Alper SL, Friedman DJ, Pollak MR. Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3712-3721. PMID: 30733285.
    Citations:    
  2. Poyan Mehr A, Sadeghi-Najafabadi M, Chau K, Messmer J, Pai R, Roy N, Friedman D, Pollak MR, Schlondorff J, Naljayan M, Singh T, Lecker SH, Rodby R, Germain M, Rennke H, Stillman IE. The Glomerular Disease Study and Trial Consortium: A Grassroots Initiative to Foster Collaboration and Innovation. Kidney Int Rep. 2019 Jan; 4(1):20-29. PMID: 30596165.
    Citations:    
  3. Subramanian B, Kaya O, Pollak MR, Yao G, Zhou J. Guided tissue organization and disease modeling in a kidney tubule array. Biomaterials. 2018 Nov; 183:295-305. PMID: 30189357.
    Citations:    Fields:    
  4. Franceschini N, Kopp JB, Barac A, Martin LW, Li Y, Qian H, Reiner AP, Pollak M, Wallace RB, Rosamond WD, Winkler CA. Association of APOL1 With Heart Failure With Preserved Ejection Fraction in Postmenopausal African American Women. JAMA Cardiol. 2018 Aug 01; 3(8):712-720. PMID: 29971324.
    Citations:    Fields:    
  5. Fan Y, Liu W, Bi R, Densmore MJ, Sato T, Mannstadt M, Yuan Q, Zhou X, Olauson H, Larsson TE, Toka HR, Pollak MR, Brown EM, Lanske B. Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3749-E3758. PMID: 29618612.
    Citations:    Fields:    Translation:Animals
  6. Zhang JY, Wang M, Tian L, Genovese G, Yan P, Wilson JG, Thadhani R, Mottl AK, Appel GB, Bick AG, Sampson MG, Alper SL, Friedman DJ, Pollak MR. UBD modifies APOL1-induced kidney disease risk. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):3446-3451. PMID: 29531077.
    Citations:    Fields:    Translation:Humans
  7. Skorecki KL, Lee JH, Langefeld CD, Rosset S, Tzur S, Wasser WG, Shemer R, Hawkins GA, Divers J, Parekh RS, Li M, Sampson MG, Kretzler M, Pollak MR, Shah S, Blackler D, Nichols B, Wilmot M, Alper SL, Freedman BI, Friedman DJ. A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. Nephrol Dial Transplant. 2018 02 01; 33(2):323-330. PMID: 28339911.
    Citations: 1     Fields:    
  8. Feng D, Notbohm J, Benjamin A, He S, Wang M, Ang LH, Bantawa M, Bouzid M, Del Gado E, Krishnan R, Pollak MR. Disease-causing mutation in a-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1517-1522. PMID: 29378953.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Feng D, DuMontier C, Pollak MR. Mechanical challenges and cytoskeletal impairments in focal segmental glomerulosclerosis. Am J Physiol Renal Physiol. 2018 May 01; 314(5):F921-F925. PMID: 29363327.
    Citations:    Fields:    
  10. Pollak MR. Introduction: APOL1-Associated Kidney Disease. Semin Nephrol. 2017 11; 37(6):489. PMID: 29110755.
    Citations:    Fields:    Translation:Humans
  11. Gucalp A, Iyengar NM, Zhou XK, Giri DD, Falcone DJ, Wang H, Williams S, Krasne MD, Yaghnam I, Kunzel B, Morris PG, Jones LW, Pollak M, Laudone VP, Hudis CA, Scher HI, Scardino PT, Eastham JA, Dannenberg AJ. Periprostatic adipose inflammation is associated with high-grade prostate cancer. Prostate Cancer Prostatic Dis. 2017 12; 20(4):418-423. PMID: 28653675.
    Citations: 2     Fields:    Translation:Humans
  12. Sato T, Courbebaisse M, Ide N, Fan Y, Hanai JI, Kaludjerovic J, Densmore MJ, Yuan Q, Toka HR, Pollak MR, Hou J, Lanske B. Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14. Proc Natl Acad Sci U S A. 2017 04 18; 114(16):E3344-E3353. PMID: 28373577.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Wang H, Pun PH, Kwee L, Craig D, Haynes C, Chryst-Ladd M, Svetkey LP, Patel UD, Hauser ER, Pollak MR, Kraus WE, Shah SH. Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization. Cardiorenal Med. 2017 Feb; 7(2):96-103. PMID: 28611783.
    Citations:    
  14. Feng D, Steinke JM, Krishnan R, Birrane G, Pollak MR. Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing. PLoS One. 2016; 11(12):e0167467. PMID: 27977723.
    Citations: 1     Fields:    Translation:Humans
  15. Shukha K, Mueller JL, Chung RT, Curry MP, Friedman DJ, Pollak MR, Berg AH. Most ApoL1 Is Secreted by the Liver. J Am Soc Nephrol. 2017 Apr; 28(4):1079-1083. PMID: 27932478.
    Citations: 5     Fields:    Translation:Humans
  16. Pollak M. Genetics of Familial FSGS. Semin Nephrol. 2016 11; 36(6):467-472. PMID: 27987547.
    Citations: 2     Fields:    Translation:HumansCells
  17. Greka A, Gibson D, Mundel P, Demetri G, Hildebrandt F, Pollak M, Florez J. Personalized Comments on Challenges and Opportunities in Kidney Disease Therapeutics: The Glom-NExT Symposium. Semin Nephrol. 2016 11; 36(6):448. PMID: 27987543.
    Citations: 2     Fields:    Translation:Humans
  18. Bondzie PA, Chen HA, Cao MZ, Tomolonis JA, He F, Pollak MR, Henderson JM. Non-muscle myosin-IIA is critical for podocyte f-actin organization, contractility, and attenuation of cell motility. Cytoskeleton (Hoboken). 2016 Aug; 73(8):377-95. PMID: 27232264.
    Citations: 1     Fields:    Translation:HumansCells
  19. Subramanian B, Sun H, Yan P, Charoonratana VT, Higgs HN, Wang F, Lai KV, Valenzuela DM, Brown EJ, Schlöndorff JS, Pollak MR. Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury. Kidney Int. 2016 08; 90(2):363-372. PMID: 27350175.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Sharma AK, Friedman DJ, Pollak MR, Alper SL. Structural characterization of the C-terminal coiled-coil domains of wild-type and kidney disease-associated mutants of apolipoprotein L1. FEBS J. 2016 05; 283(10):1846-62. PMID: 26945671.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Friedman DJ, Pollak MR. Apolipoprotein L1 and Kidney Disease in African Americans. Trends Endocrinol Metab. 2016 Apr; 27(4):204-215. PMID: 26947522.
    Citations: 11     Fields:    Translation:HumansAnimals
  22. Olabisi O, Al-Romaih K, Henderson J, Tomar R, Drummond I, MacRae C, Pollak M. From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? Clin Nephrol. 2016 Supplement 1; 86 (2016)(13):114-118. PMID: 27509583.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Olabisi OA, Zhang JY, VerPlank L, Zahler N, DiBartolo S, Heneghan JF, Schlöndorff JS, Suh JH, Yan P, Alper SL, Friedman DJ, Pollak MR. APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):830-7. PMID: 26699492.
    Citations: 34     Fields:    Translation:HumansCells
  24. Mukamal KJ, Tremaglio J, Friedman DJ, Ix JH, Kuller LH, Tracy RP, Pollak MR. APOL1 Genotype, Kidney and Cardiovascular Disease, and Death in Older Adults. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):398-403. PMID: 26634651.
    Citations: 20     Fields:    Translation:Humans
  25. Allen DB, Backeljauw P, Bidlingmaier M, Biller BM, Boguszewski M, Burman P, Butler G, Chihara K, Christiansen J, Cianfarani S, Clayton P, Clemmons D, Cohen P, Darendeliler F, Deal C, Dunger D, Erfurth EM, Fuqua JS, Grimberg A, Haymond M, Higham C, Ho K, Hoffman AR, Hokken-Koelega A, Johannsson G, Juul A, Kopchick J, Lee P, Pollak M, Radovick S, Robison L, Rosenfeld R, Ross RJ, Savendahl L, Saenger P, Sorensen HT, Stochholm K, Strasburger C, Swerdlow A, Thorner M. GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults. Eur J Endocrinol. 2016 02; 174(2):P1-9. PMID: 26563978.
    Citations: 22     Fields:    Translation:Humans
  26. MacRae CA, Pollak MR. Effect Size Does Matter: The Long Road to Mechanistic Insight From Genome-Wide Association. Circulation. 2015 Nov 24; 132(21):1943-5. PMID: 26487758.
    Citations: 1     Fields:    Translation:HumansCells
  27. Feng D, DuMontier C, Pollak MR. The role of alpha-actinin-4 in human kidney disease. Cell Biosci. 2015; 5:44. PMID: 26301083.
    Citations: 8     
  28. Toka HR, Pollak MR, Houillier P. Calcium Sensing in the Renal Tubule. Physiology (Bethesda). 2015 Jul; 30(4):317-26. PMID: 26136545.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Heneghan JF, Vandorpe DH, Shmukler BE, Giovinazzo JA, Giovinnazo JA, Raper J, Friedman DJ, Pollak MR, Alper SL. BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. Am J Physiol Cell Physiol. 2015 Sep 01; 309(5):C332-47. PMID: 26108665.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  30. Pollak MR. Modifiers of Cardiac Phenotypes. Circ Cardiovasc Genet. 2015 Jun; 8(3):425-6. PMID: 26082553.
    Citations:    Fields:    Translation:Humans
  31. Sampson MG, Pollak MR. Opportunities and Challenges of Genotyping Patients With Nephrotic Syndrome in the Genomic Era. Semin Nephrol. 2015 May; 35(3):212-21. PMID: 26215859.
    Citations: 7     Fields:    Translation:Humans
  32. Ruchi R, Genovese G, Lee J, Charoonratana VT, Bernhardy AJ, Alper SL, Kopp JB, Thadhani R, Friedman DJ, Pollak MR. Copy Number Variation at the APOL1 Locus. PLoS One. 2015; 10(5):e0125410. PMID: 25933006.
    Citations: 4     Fields:    Translation:Humans
  33. Ehrlicher AJ, Krishnan R, Guo M, Bidan CM, Weitz DA, Pollak MR. Alpha-actinin binding kinetics modulate cellular dynamics and force generation. Proc Natl Acad Sci U S A. 2015 May 26; 112(21):6619-24. PMID: 25918384.
    Citations: 21     Fields:    Translation:HumansCells
  34. Pollak MR. Idiopathic pediatric chronic kidney disease: can genomic technology crack the case? J Clin Invest. 2015 May; 125(5):1799-800. PMID: 25893596.
    Citations:    Fields:    Translation:HumansCells
  35. Joerger M, van Schaik RH, Becker ML, Hayoz S, Pollak M, Cathomas R, Winterhalder R, Gillessen S, Rothermundt C. Multidrug and toxin extrusion 1 and human organic cation transporter 1 polymorphisms in patients with castration-resistant prostate cancer receiving metformin (SAKK 08/09). Prostate Cancer Prostatic Dis. 2015 Jun; 18(2):167-72. PMID: 25753371.
    Citations: 2     Fields:    Translation:Humans
  36. Kopp JB, Winkler CA, Zhao X, Radeva MK, Gassman JJ, D'Agati VD, Nast CC, Wei C, Reiser J, Guay-Woodford LM, Pollak MR, Hildebrandt F, Moxey-Mims M, Gipson DS, Trachtman H, Friedman AL, Kaskel FJ. Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial. J Am Soc Nephrol. 2015 Jun; 26(6):1443-8. PMID: 25573908.
    Citations: 33     Fields:    Translation:Humans
  37. Sun H, Al-Romaih KI, MacRae CA, Pollak MR. Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus. EBioMedicine. 2014 Dec; 1(2-3):107-15. PMID: 26086034.
    Citations: 8     Fields:    
  38. Toka HR, Pollak MR. The role of the calcium-sensing receptor in disorders of abnormal calcium handling and cardiovascular disease. Curr Opin Nephrol Hypertens. 2014 Sep; 23(5):494-501. PMID: 24992569.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  39. Pollak MR. Familial FSGS. Adv Chronic Kidney Dis. 2014 Sep; 21(5):422-5. PMID: 25168831.
    Citations: 16     Fields:    Translation:Humans
  40. Nichols B, Jog P, Lee JH, Blackler D, Wilmot M, D'Agati V, Markowitz G, Kopp JB, Alper SL, Pollak MR, Friedman DJ. Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1. Kidney Int. 2015 Feb; 87(2):332-42. PMID: 25100047.
    Citations: 70     Fields:    Translation:HumansCells
  41. Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, Cheng D, Saleem MA, Satchell SC, Banas B, Mathieson PW, Kretzler M, Hemal AK, Rudel LL, Petrovic S, Weckerle A, Pollak MR, Ross MD, Parks JS, Freedman BI. Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol. 2015 Feb; 26(2):339-48. PMID: 25012173.
    Citations: 48     Fields:    Translation:HumansCells
  42. Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, Amodu O, Anabwani G, Andersen K, Arogundade F, Arulogun O, Asogun D, Bakare R, Balde N, Baniecki ML, Beiswanger C, Benkahla A, Bethke L, Boehnke M, Boima V, Brandful J, Brooks AI, Brosius FC, Brown C, Bucheton B, Burke DT, Burnett BG, Carrington-Lawrence S, Carstens N, Chisi J, Christoffels A, Cooper R, Cordell H, Crowther N, Croxton T, de Vries J, Derr L, Donkor P, Doumbia S, Duncanson A, Ekem I, El Sayed A, Engel ME, Enyaru JC, Everett D, Fadlelmola FM, Fakunle E, Fischbeck KH, Fischer A, Folarin O, Gamieldien J, Garry RF, Gaseitsiwe S, Gbadegesin R, Ghansah A, Giovanni M, Goesbeck P, Gomez-Olive FX, Grant DS, Grewal R, Guyer M, Hanchard NA, Happi CT, Hazelhurst S, Hennig BJ, Hertz- C, Hide W, Hilderbrandt F, Hugo-Hamman C, Ibrahim ME, James R, Jaufeerally-Fakim Y, Jenkins C, Jentsch U, Jiang PP, Joloba M, Jongeneel V, Joubert F, Kader M, Kahn K, Kaleebu P, Kapiga SH, Kassim SK, Kasvosve I, Kayondo J, Keavney B, Kekitiinwa A, Khan SH, Kimmel P, King MC, Kleta R, Koffi M, Kopp J, Kretzler M, Kumuthini J, Kyobe S, Kyobutungi C, Lackland DT, Lacourciere KA, Landouré G, Lawlor R, Lehner T, Lesosky M, Levitt N, Littler K, Lombard Z, Loring JF, Lyantagaye S, Macleod A, Madden EB, Mahomva CR, Makani J, Mamven M, Marape M, Mardon G, Marshall P, Martin DP, Masiga D, Mason R, Mate-Kole M, Matovu E, Mayige M, Mayosi BM, Mbanya JC, McCurdy SA, McCarthy MI, McIlleron H, Mc'Ligeyo SO, Merle C, Mocumbi AO, Mondo C, Moran JV, Motala A, Moxey-Mims M, Mpoloka WS, Msefula CL, Mthiyane T, Mulder N, Mulugeta Gh, Mumba D, Musuku J, Nagdee M, Nash O, Ndiaye D, Nguyen AQ, Nicol M, Nkomazana O, Norris S, Nsangi B, Nyarko A, Nyirenda M, Obe E, Obiakor R, Oduro A, Ofori-Acquah SF, Ogah O, Ogendo S, Ohene-Frempong K, Ojo A, Olanrewaju T, Oli J, Osafo C, Ouwe Missi Oukem-Boyer O, Ovbiagele B, Owen A, Owolabi MO, Owolabi L, Owusu-Dabo E, Pare G, Parekh R, Patterton HG, Penno MB, Peterson J, Pieper R, Plange-Rhule J, Pollak M, Puzak J, Ramesar RS, Ramsay M, Rasooly R, Reddy S, Sabeti PC, Sagoe K, Salako T, Samassékou O, Sandhu MS, Sankoh O, Sarfo FS, Sarr M, Shaboodien G, Sidibe I, Simo G, Simuunza M, Smeeth L, Sobngwi E, Soodyall H, Sorgho H, Sow Bah O, Srinivasan S, Stein DJ, Susser ES, Swanepoel C, Tangwa G, Tareila A, Tastan Bishop O, Tayo B, Tiffin N, Tinto H, Tobin E, Tollman SM, Traoré M, Treadwell MJ, Troyer J, Tsimako-Johnstone M, Tukei V, Ulasi I, Ulenga N, van Rooyen B, Wachinou AP, Waddy SP, Wade A, Wayengera M, Whitworth J, Wideroff L, Winkler CA, Winnicki S, Wonkam A, Yewondwos M, sen T, Yozwiak N, Zar H. Research capacity. Enabling the genomic revolution in Africa. Science. 2014 Jun 20; 344(6190):1346-8. PMID: 24948725.
    Citations: 79     Fields:    Translation:Humans
  43. Grgic I, Hofmeister AF, Genovese G, Bernhardy AJ, Sun H, Maarouf OH, Bijol V, Pollak MR, Humphreys BD. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. Kidney Int. 2014 Dec; 86(6):1116-29. PMID: 24940801.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  44. Pollak MR, Quaggin SE, Hoenig MP, Dworkin LD. The glomerulus: the sphere of influence. Clin J Am Soc Nephrol. 2014 Aug 07; 9(8):1461-9. PMID: 24875196.
    Citations: 9     Fields:    Translation:HumansAnimals
  45. Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):E2130-9. PMID: 24808134.
    Citations: 62     Fields:    Translation:HumansAnimals
  46. Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol. 2014 Sep; 25(9):1991-2002. PMID: 24676636.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  47. Barua M, Stellacci E, Stella L, Weins A, Genovese G, Muto V, Caputo V, Toka HR, Charoonratana VT, Tartaglia M, Pollak MR. Mutations in PAX2 associate with adult-onset FSGS. J Am Soc Nephrol. 2014 Sep; 25(9):1942-53. PMID: 24676634.
    Citations: 13     Fields:    Translation:HumansCells
  48. Brown EJ, Pollak MR, Barua M. Genetic testing for nephrotic syndrome and FSGS in the era of next-generation sequencing. Kidney Int. 2014 May; 85(5):1030-8. PMID: 24599252.
    Citations: 20     Fields:    Translation:Humans
  49. Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov MG, Depalma SR, Gupta N, Gabriel SB, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, Hirschhorn JN, Altshuler DM, Pollak MR, Wilson JG, Seidman JG, Seidman C. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ Res. 2014 Feb 28; 114(5):845-50. PMID: 24379297.
    Citations: 54     Fields:    Translation:Humans
  50. Ashraf S, Gee HY, Woerner S, Xie LX, Vega-Warner V, Lovric S, Fang H, Song X, Cattran DC, Avila-Casado C, Paterson AD, Nitschké P, Bole-Feysot C, Cochat P, Esteve-Rudd J, Haberberger B, Allen SJ, Zhou W, Airik R, Otto EA, Barua M, Al-Hamed MH, Kari JA, Evans J, Bierzynska A, Saleem MA, Böckenhauer D, Kleta R, El Desoky S, Hacihamdioglu DO, Gok F, Washburn J, Wiggins RC, Choi M, Lifton RP, Levy S, Han Z, Salviati L, Prokisch H, Williams DS, Pollak M, Clarke CF, Pei Y, Antignac C, Hildebrandt F. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. J Clin Invest. 2013 Dec; 123(12):5179-89. PMID: 24270420.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  51. Bruggeman LA, O'Toole JF, Ross MD, Madhavan SM, Smurzynski M, Wu K, Bosch RJ, Gupta S, Pollak MR, Sedor JR, Kalayjian RC. Plasma apolipoprotein L1 levels do not correlate with CKD. J Am Soc Nephrol. 2014 Mar; 25(3):634-44. PMID: 24231663.
    Citations: 33     Fields:    Translation:Humans
  52. Williams WW, Pollak MR. Health disparities in kidney disease--emerging data from the human genome. N Engl J Med. 2013 Dec 05; 369(23):2260-1. PMID: 24206461.
    Citations: 4     Fields:    Translation:Humans
  53. Barua M, Shieh E, Schlondorff J, Genovese G, Kaplan BS, Pollak MR. Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis. Kidney Int. 2014 Jan; 85(1):124-33. PMID: 24048372.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  54. Toka HR, Genovese G, Mount DB, Pollak MR, Curhan GC. Frequency of rare allelic variation in candidate genes among individuals with low and high urinary calcium excretion. PLoS One. 2013; 8(8):e71885. PMID: 23991001.
    Citations: 2     Fields:    Translation:Humans
  55. Toka HR, Yang J, Zera CA, Duffield JS, Pollak MR, Mount DB. Pregnancy-associated polyuria in familial renal glycosuria. Am J Kidney Dis. 2013 Dec; 62(6):1160-4. PMID: 23871407.
    Citations: 1     Fields:    Translation:Humans
  56. Romero JR, Youte R, Brown EM, Pollak MR, Goltzman D, Karaplis A, Pong LC, Chien L, Chattopadhyay N, Rivera A. Parathyroid hormone ablation alters erythrocyte parameters that are rescued by calcium-sensing receptor gene deletion. Eur J Haematol. 2013 Jul; 91(1):37-45. PMID: 23528155.
    Citations: 1     Fields:    Translation:AnimalsCells
  57. Sun H, Schlondorff J, Higgs HN, Pollak MR. Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling. J Am Soc Nephrol. 2013 May; 24(6):917-29. PMID: 23620398.
    Citations: 16     Fields:    Translation:HumansCells
  58. Genovese G, Friedman DJ, Pollak MR. APOL1 variants and kidney disease in people of recent African ancestry. Nat Rev Nephrol. 2013 04; 9(4):240-4. PMID: 23438974.
    Citations: 34     Fields:    Translation:Humans
  59. Genovese G, Handsaker RE, Li H, Altemose N, Lindgren AM, Chambert K, Pasaniuc B, Price AL, Reich D, Morton CC, Pollak MR, Wilson JG, McCarroll SA. Using population admixture to help complete maps of the human genome. Nat Genet. 2013 Apr; 45(4):406-14, 414e1-2. PMID: 23435088.
    Citations: 28     Fields:    Translation:HumansCells
  60. Kirby A, Gnirke A, Jaffe DB, Barešová V, Pochet N, Blumenstiel B, Ye C, Aird D, Stevens C, Robinson JT, Cabili MN, Gat-Viks I, Kelliher E, Daza R, DeFelice M, Hulková H, Sovová J, Vylet'al P, Antignac C, Guttman M, Handsaker RE, Perrin D, Steelman S, Sigurdsson S, Scheinman SJ, Sougnez C, Cibulskis K, Parkin M, Green T, Rossin E, Zody MC, Xavier RJ, Pollak MR, Alper SL, Lindblad-Toh K, Gabriel S, Hart PS, Regev A, Nusbaum C, Kmoch S, Bleyer AJ, Lander ES, Daly MJ. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Nat Genet. 2013 Mar; 45(3):299-303. PMID: 23396133.
    Citations: 57     Fields:    Translation:HumansCells
  61. Quinn SJ, Thomsen AR, Egbuna O, Pang J, Baxi K, Goltzman D, Pollak M, Brown EM. CaSR-mediated interactions between calcium and magnesium homeostasis in mice. Am J Physiol Endocrinol Metab. 2013 Apr 01; 304(7):E724-33. PMID: 23360827.
    Citations: 7     Fields:    Translation:Animals
  62. Yao NY, Broedersz CP, Depken M, Becker DJ, Pollak MR, Mackintosh FC, Weitz DA. Stress-enhanced gelation: a dynamic nonlinearity of elasticity. Phys Rev Lett. 2013 Jan 04; 110(1):018103. PMID: 23383843.
    Citations: 7     Fields:    Translation:Humans
  63. Quinn SJ, Thomsen AR, Pang JL, Kantham L, Bräuner-Osborne H, Pollak M, Goltzman D, Brown EM. Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. Am J Physiol Endocrinol Metab. 2013 Feb 01; 304(3):E310-20. PMID: 23233539.
    Citations: 21     Fields:    Translation:Animals
  64. Carrasquillo R, Tian D, Krishna S, Pollak MR, Greka A, Schlöndorff J. SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. BMC Cell Biol. 2012 Nov 21; 13:33. PMID: 23171048.
    Citations: 3     Fields:    Translation:HumansCells
  65. Barua M, Brown EJ, Charoonratana VT, Genovese G, Sun H, Pollak MR. Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis. Kidney Int. 2013 Feb; 83(2):316-22. PMID: 23014460.
    Citations: 34     Fields:    Translation:HumansCells
  66. Toka HR, Al-Romaih K, Koshy JM, DiBartolo S, Kos CH, Quinn SJ, Curhan GC, Mount DB, Brown EM, Pollak MR. Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol. 2012 Nov; 23(11):1879-90. PMID: 22997254.
    Citations: 17     Fields:    Translation:AnimalsCells
  67. Lee BT, Kumar V, Williams TA, Abdi R, Bernhardy A, Dyer C, Conte S, Genovese G, Ross MD, Friedman DJ, Gaston R, Milford E, Pollak MR, Chandraker A. The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival. Am J Transplant. 2012 Jul; 12(7):1924-8. PMID: 22487534.
    Citations: 56     Fields:    Translation:Humans
  68. Pollak MR, Genovese G, Friedman DJ. APOL1 and kidney disease. Curr Opin Nephrol Hypertens. 2012 Mar; 21(2):179-82. PMID: 22257798.
    Citations: 19     Fields:    Translation:Humans
  69. Xue Y, Xiao Y, Liu J, Karaplis AC, Pollak MR, Brown EM, Miao D, Goltzman D. The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice. Am J Physiol Endocrinol Metab. 2012 Apr 01; 302(7):E841-51. PMID: 22275754.
    Citations: 11     Fields:    Translation:AnimalsCells
  70. Boucher I, Yu W, Beaudry S, Negoro H, Tran M, Pollak MR, Henderson JM, Denker BM. Ga12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. Lab Invest. 2012 May; 92(5):662-75. PMID: 22249312.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  71. Friedman DJ, Kozlitina J, Genovese G, Jog P, Pollak MR. Population-based risk assessment of APOL1 on renal disease. J Am Soc Nephrol. 2011 Nov; 22(11):2098-105. PMID: 21997396.
    Citations: 81     Fields:    Translation:Humans
  72. Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol. 2011 Nov; 22(11):2129-37. PMID: 21997394.
    Citations: 214     Fields:    Translation:Humans
  73. Kanji Z, Powe CE, Wenger JB, Huang C, Ankers E, Sullivan DA, Collerone G, Powe NR, Tonelli M, Bhan I, Bernhardy AJ, Dibartolo S, Friedman D, Genovese G, Pollak MR, Thadhani R. Genetic variation in APOL1 associates with younger age at hemodialysis initiation. J Am Soc Nephrol. 2011 Nov; 22(11):2091-7. PMID: 21997398.
    Citations: 33     Fields:    Translation:Humans
  74. Akilesh S, Suleiman H, Yu H, Stander MC, Lavin P, Gbadegesin R, Antignac C, Pollak M, Kopp JB, Winn MP, Shaw AS. Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. J Clin Invest. 2011 Oct; 121(10):4127-37. PMID: 21911940.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  75. Friedman DJ, Pollak MR. Genetics of kidney failure and the evolving story of APOL1. J Clin Invest. 2011 Sep; 121(9):3367-74. PMID: 21881214.
    Citations: 42     Fields:    Translation:Humans
  76. Shankland SJ, Pollak MR. A suPAR circulating factor causes kidney disease. Nat Med. 2011 Aug 04; 17(8):926-7. PMID: 21818086.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  77. Yao NY, Becker DJ, Broedersz CP, Depken M, Mackintosh FC, Pollak MR, Weitz DA. Nonlinear viscoelasticity of actin transiently cross-linked with mutant a-actinin-4. J Mol Biol. 2011 Sep 02; 411(5):1062-71. PMID: 21762701.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  78. Al-Romaih KI, Genovese G, Al-Mojalli H, Al-Othman S, Al-Manea H, Al-Suleiman M, Al-Jondubi M, Atallah N, Al-Rodayyan M, Weins A, Pollak MR, Adra CN. Genetic diagnosis in consanguineous families with kidney disease by homozygosity mapping coupled with whole-exome sequencing. Am J Kidney Dis. 2011 Aug; 58(2):186-95. PMID: 21658830.
    Citations: 8     Fields:    Translation:Humans
  79. Suissa S, Azoulay L, Dell'Aniello S, Evans M, Vora J, Pollak M. Long-term effects of insulin glargine on the risk of breast cancer. Diabetologia. 2011 Sep; 54(9):2254-62. PMID: 21614572.
    Citations: 40     Fields:    Translation:Humans
  80. Shu L, Ji J, Zhu Q, Cao G, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D. The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. J Bone Miner Res. 2011 May; 26(5):1057-71. PMID: 21542007.
    Citations: 16     Fields:    Translation:AnimalsCells
  81. Liakopoulos V, Huerta A, Cohen S, Pollak MR, Sirota RA, Superdock K, Appel GB. Familial collapsing focal segmental glomerulosclerosis. Clin Nephrol. 2011 Apr; 75(4):362-8. PMID: 21426891.
    Citations: 7     Fields:    Translation:Humans
  82. Sun H, Schlondorff JS, Brown EJ, Higgs HN, Pollak MR. Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2). Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2933-8. PMID: 21278336.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  83. Wyss HM, Henderson JM, Byfield FJ, Bruggeman LA, Ding Y, Huang C, Suh JH, Franke T, Mele E, Pollak MR, Miner JH, Janmey PA, Weitz DA, Miller RT. Biophysical properties of normal and diseased renal glomeruli. Am J Physiol Cell Physiol. 2011 Mar; 300(3):C397-405. PMID: 21123730.
    Citations: 26     Fields:    Translation:AnimalsCells
  84. Broedersz CP, Depken M, Yao NY, Pollak MR, Weitz DA, MacKintosh FC. Cross-link-governed dynamics of biopolymer networks. Phys Rev Lett. 2010 Dec 03; 105(23):238101. PMID: 21231506.
    Citations: 14     Fields:    
  85. Algire C, Amrein L, Bazile M, David S, Zakikhani M, Pollak M. Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene. 2011 Mar 10; 30(10):1174-82. PMID: 21102522.
    Citations: 60     Fields:    Translation:AnimalsCells
  86. Shao H, Wang JH, Pollak MR, Wells A. a-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts. PLoS One. 2010 Nov 11; 5(11):e13921. PMID: 21085685.
    Citations: 30     Fields:    Translation:AnimalsCells
  87. Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 03; 29(21):3593-606. PMID: 20935625.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  88. Feng J, Petersen CD, Coy DH, Jiang JK, Thomas CJ, Pollak MR, Wank SA. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17791-6. PMID: 20876097.
    Citations: 31     Fields:    Translation:AnimalsCells
  89. Parikh SM, Pollak MR. VEGF receptors and glomerular function. J Am Soc Nephrol. 2010 Oct; 21(10):1599-600. PMID: 20847145.
    Citations:    Fields:    Translation:AnimalsCells
  90. Schachter ME, Monahan M, Radhakrishnan J, Crew J, Pollak M, Ratner L, Valeri AM, Stokes MB, Appel GB. Recurrent focal segmental glomerulosclerosis in the renal allograft: single center experience in the era of modern immunosuppression. Clin Nephrol. 2010 Sep; 74(3):173-81. PMID: 20860901.
    Citations: 10     Fields:    Translation:Humans
  91. Thomas JA, Antonelli JA, Lloyd JC, Masko EM, Poulton SH, Phillips TE, Pollak M, Freedland SJ. Effect of intermittent fasting on prostate cancer tumor growth in a mouse model. Prostate Cancer Prostatic Dis. 2010 Dec; 13(4):350-5. PMID: 20733612.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  92. Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol. 2010 Sep; 21(9):1422-6. PMID: 20688934.
    Citations: 113     Fields:    Translation:HumansAnimals
  93. Genovese G, Tonna SJ, Knob AU, Appel GB, Katz A, Bernhardy AJ, Needham AW, Lazarus R, Pollak MR. A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. Kidney Int. 2010 Oct; 78(7):698-704. PMID: 20668430.
    Citations: 62     Fields:    Translation:Humans
  94. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13; 329(5993):841-5. PMID: 20647424.
    Citations: 557     Fields:    Translation:HumansAnimals
  95. Pollak MR. Genetics and genetic testing in kidney disease: introduction. Semin Nephrol. 2010 Jul; 30(4):355. PMID: 20807607.
    Citations:    Fields:    Translation:Humans
  96. Genovese G, Leibon G, Pollak MR, Rockmore DN. Improved IBD detection using incomplete haplotype information. BMC Genet. 2010 Jun 30; 11:58. PMID: 20591167.
    Citations: 6     Fields:    Translation:Humans
  97. Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE. Metabolite profiling identifies markers of uremia. J Am Soc Nephrol. 2010 Jun; 21(6):1041-1051. PMID: 20378825.
    Citations: 49     Fields:    Translation:Humans
  98. Pollak M, Russell-Jones D. Insulin analogues and cancer risk: cause for concern or cause célèbre? Int J Clin Pract. 2010 Apr; 64(5):628-36. PMID: 20201993.
    Citations: 18     Fields:    Translation:Humans
  99. Sun W, Sun W, Liu J, Zhou X, Xiao Y, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D. Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development. 2010 Mar; 137(6):985-92. PMID: 20150282.
    Citations: 12     Fields:    Translation:AnimalsCells
  100. Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nat Genet. 2010 Jan; 42(1):72-6. PMID: 20023659.
    Citations: 153     Fields:    Translation:HumansCells
  101. Pollak MR. Expanding the spectrum of NPHS1-associated disease. Kidney Int. 2009 Dec; 76(12):1221-3. PMID: 19946311.
    Citations: 1     Fields:    Translation:Humans
  102. Kantham L, Quinn SJ, Egbuna OI, Baxi K, Butters R, Pang JL, Pollak MR, Goltzman D, Brown EM. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab. 2009 Oct; 297(4):E915-23. PMID: 19797241.
    Citations: 34     Fields:    Translation:Animals
  103. Pollak MR. Surprising results following conditional podocyte inactivation. J Am Soc Nephrol. 2009 Oct; 20(10):2086-8. PMID: 19762489.
    Citations: 1     Fields:    Translation:AnimalsCells
  104. Egbuna O, Quinn S, Kantham L, Butters R, Pang J, Pollak M, Goltzman D, Brown E. The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone. Am J Physiol Renal Physiol. 2009 Sep; 297(3):F720-8. PMID: 19474191.
    Citations: 10     Fields:    Translation:Animals
  105. Gualberto A, Dolled-Filhart MP, Hixon ML, Christensen J, Rimm DL, Lee AV, Wang Y, Pollak M, Paz-Ares LG, Karp DD. Molecular bases for sensitivity to figitumumab (CP-751,871) in NSCLC. J Clin Oncol. 2009 May 20; 27(15_suppl):8091. PMID: 27962669.
    Citations:    
  106. Hixon ML, Gualberto A, Demers L, Paz-Ares LG, Novello S, Blakely LJ, Langer CL, Lipton A, Pollak M, Karp DD. Correlation of plasma levels of free insulin-like growth factor 1 and clinical benefit of the IGF-IR inhibitor figitumumab (CP- 751, 871). J Clin Oncol. 2009 May 20; 27(15_suppl):3539. PMID: 27961330.
    Citations:    
  107. Ali SM, Chapman JW, Demers L, Shepherd L, Han L, Wilson C, Pritchard K, Leitzel K, Pollak M, Lipton A. Effect of adjuvant chemotherapy on bone resorption marker beta C-telopeptide (B-CTX) in postmenopausal women. J Clin Oncol. 2009 May 20; 27(15_suppl):594. PMID: 27960704.
    Citations:    
  108. Henderson JM, Alexander MP, Pollak MR. Patients with ACTN4 mutations demonstrate distinctive features of glomerular injury. J Am Soc Nephrol. 2009 May; 20(5):961-8. PMID: 19357256.
    Citations: 18     Fields:    Translation:HumansCells
  109. Schlöndorff J, Del Camino D, Carrasquillo R, Lacey V, Pollak MR. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. Am J Physiol Cell Physiol. 2009 Mar; 296(3):C558-69. PMID: 19129465.
    Citations: 48     Fields:    Translation:HumansCells
  110. Pollak MR. Kidney disease and African ancestry. Nat Genet. 2008 Oct; 40(10):1145-6. PMID: 18818713.
    Citations: 3     Fields:    Translation:HumansCells
  111. Tonna SJ, Needham A, Polu K, Uscinski A, Appel GB, Falk RJ, Katz A, Al-Waheeb S, Kaplan BS, Jerums G, Savige J, Harmon J, Zhang K, Curhan GC, Pollak MR. NPHS2 variation in focal and segmental glomerulosclerosis. BMC Nephrol. 2008 Sep 29; 9:13. PMID: 18823551.
    Citations: 19     Fields:    Translation:Humans
  112. Ward SM, Weins A, Pollak MR, Weitz DA. Dynamic viscoelasticity of actin cross-linked with wild-type and disease-causing mutant alpha-actinin-4. Biophys J. 2008 Nov 15; 95(10):4915-23. PMID: 18689451.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  113. Forman JP, Fisher ND, Pollak MR, Cox DG, Tonna S, Curhan GC. Renin-angiotensin system polymorphisms and risk of hypertension: influence of environmental factors. J Clin Hypertens (Greenwich). 2008 Jun; 10(6):459-66. PMID: 18550936.
    Citations: 2     Fields:    Translation:Humans
  114. Leibon G, Rockmore DN, Pollak MR. A SNP streak model for the identification of genetic regions identical-by-descent. Stat Appl Genet Mol Biol. 2008; 7(1):Article16. PMID: 18518857.
    Citations: 15     Fields:    Translation:Humans
  115. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K. Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6998-7003. PMID: 18458324.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  116. Pollak MR. Focal segmental glomerulosclerosis: recent advances. Curr Opin Nephrol Hypertens. 2008 Mar; 17(2):138-42. PMID: 18277145.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  117. Henderson JM, Al-Waheeb S, Weins A, Dandapani SV, Pollak MR. Mice with altered alpha-actinin-4 expression have distinct morphologic patterns of glomerular disease. Kidney Int. 2008 Mar; 73(6):741-50. PMID: 18185509.
    Citations: 13     Fields:    Translation:HumansAnimals
  118. Lee SH, Weins A, Hayes DB, Pollak MR, Dominguez R. Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J Mol Biol. 2008 Feb 15; 376(2):317-24. PMID: 18164029.
    Citations: 12     Fields:    Translation:HumansCells
  119. Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). Gene. 2008 Feb 29; 410(1):44-52. PMID: 18206321.
    Citations: 2     Fields:    Translation:Humans
  120. Mistry K, Ireland JH, Ng RC, Henderson JM, Pollak MR. Novel mutations in NPHP4 in a consanguineous family with histological findings of focal segmental glomerulosclerosis. Am J Kidney Dis. 2007 Nov; 50(5):855-64. PMID: 17954299.
    Citations: 3     Fields:    Translation:Humans
  121. Pollak MR, Alexander MP, Henderson JM. A case of familial kidney disease. Clin J Am Soc Nephrol. 2007 Nov; 2(6):1367-74. PMID: 17942774.
    Citations: 4     Fields:    Translation:Humans
  122. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  123. Copelovitch L, Guttenberg M, Pollak MR, Kaplan BS. Renin-angiotensin axis blockade reduces proteinuria in presymptomatic patients with familial FSGS. Pediatr Nephrol. 2007 Oct; 22(10):1779-84. PMID: 17530296.
    Citations: 8     Fields:    Translation:Humans
  124. Schlöndorff JS, Pollak MR. TRPC6 in glomerular health and disease: what we know and what we believe. Semin Cell Dev Biol. 2006 Dec; 17(6):667-74. PMID: 17116414.
    Citations: 15     Fields:    Translation:HumansAnimals
  125. Dandapani SV, Sugimoto H, Matthews BD, Kolb RJ, Sinha S, Gerszten RE, Zhou J, Ingber DE, Kalluri R, Pollak MR. Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem. 2007 Jan 05; 282(1):467-77. PMID: 17082197.
    Citations: 46     Fields:    Translation:AnimalsCells
  126. Chattopadhyay N, Jeong KH, Yano S, Huang S, Pang JL, Ren X, Terwilliger E, Kaiser UB, Vassilev PM, Pollak MR, Brown EM. Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E523-32. PMID: 17003237.
    Citations: 9     Fields:    Translation:AnimalsCells
  127. Liu B, Lee KW, Anzo M, Zhang B, Zi X, Tao Y, Shiry L, Pollak M, Lin S, Cohen P. Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis. Oncogene. 2007 Mar 15; 26(12):1811-9. PMID: 16983336.
    Citations: 33     Fields:    Translation:AnimalsCells
  128. Dandapani SV, Pollak MR. The glomerular filter: Biologic and genetic complexity. Kidney Int. 2006 Sep; 70(6):980-2. PMID: 16957744.
    Citations: 1     Fields:    Translation:HumansCells
  129. Möller CC, Pollak MR, Reiser J. The genetic basis of human glomerular disease. Adv Chronic Kidney Dis. 2006 Apr; 13(2):166-73. PMID: 16580618.
    Citations: 12     Fields:    Translation:HumansCells
  130. Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature. 2006 Feb 02; 439(7076):599-603. PMID: 16382241.
    Citations: 204     Fields:    Translation:AnimalsCells
  131. Weins A, Kenlan P, Herbert S, Le TC, Villegas I, Kaplan BS, Appel GB, Pollak MR. Mutational and Biological Analysis of alpha-actinin-4 in focal segmental glomerulosclerosis. J Am Soc Nephrol. 2005 Dec; 16(12):3694-701. PMID: 16251236.
    Citations: 55     Fields:    Translation:Humans
  132. Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005 Jul; 37(7):739-44. PMID: 15924139.
    Citations: 251     Fields:    Translation:HumansCells
  133. Hunt JL, Pollak MR, Denker BM. Cultured podocytes establish a size-selective barrier regulated by specific signaling pathways and demonstrate synchronized barrier assembly in a calcium switch model of junction formation. J Am Soc Nephrol. 2005 Jun; 16(6):1593-602. PMID: 15843471.
    Citations: 14     Fields:    Translation:AnimalsCells
  134. Leykin I, Hao K, Cheng J, Meyer N, Pollak MR, Smith RJ, Wong WH, Rosenow C, Li C. Comparative linkage analysis and visualization of high-density oligonucleotide SNP array data. BMC Genet. 2005 Feb 15; 6:7. PMID: 15713228.
    Citations: 12     Fields:    Translation:Humans
  135. Ellinor PT, Moore RK, Patton KK, Ruskin JN, Pollak MR, Macrae CA. Mutations in the long QT gene, KCNQ1, are an uncommon cause of atrial fibrillation. Heart. 2004 Dec; 90(12):1487-8. PMID: 15547041.
    Citations: 25     Fields:    Translation:HumansCells
  136. Fuchs C, Pollak M, Sargent DJ, Meyerhardt JA, Ramanathan RK, Williamson S, Findlay B, Green E, Goldberg RM. Insulin-like growth factor-I (IGF-1), IGF binding protein-3 (IGFBP-3), and outcome in metastatic colorectal cancer (CRC): Results from Intergroup Trial N9741. J Clin Oncol. 2004 Jul 15; 22(14_suppl):3521. PMID: 28016522.
    Citations:    
  137. Diorio C, Pollak M, Byrne C, Mâsse B, Côté G, Hébert-Croteau N, Yaffe M, Bérubé S, Morin C, Brisson J. Insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP-3), and mammographic breast density. J Clin Oncol. 2004 Jul 15; 22(14_suppl):9501. PMID: 28016801.
    Citations:    
  138. Yao J, Le TC, Kos CH, Henderson JM, Allen PG, Denker BM, Pollak MR. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol. 2004 Jun; 2(6):e167. PMID: 15208719.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  139. Camirand A, Pollak M. Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells. Br J Cancer. 2004 May 04; 90(9):1825-9. PMID: 15150607.
    Citations: 11     Fields:    Translation:HumansCells
  140. Pereira AC, Pereira AB, Mota GF, Cunha RS, Herkenhoff FL, Pollak MR, Mill JG, Krieger JE. NPHS2 R229Q functional variant is associated with microalbuminuria in the general population. Kidney Int. 2004 Mar; 65(3):1026-30. PMID: 14871423.
    Citations: 29     Fields:    Translation:Humans
  141. Ismail HA, Pollak M, Behlouli H, Tanguay S, Bégin LR, Aprikian AG. Serum insulin-like growth factor (IGF)-1 and IGF-binding protein-3 do not correlate with Gleason score or quantity of prostate cancer in biopsy samples. BJU Int. 2003 Nov; 92(7):699-702. PMID: 14616449.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  142. Kos CH, Le TC, Sinha S, Henderson JM, Kim SH, Sugimoto H, Kalluri R, Gerszten RE, Pollak MR. Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest. 2003 Jun; 111(11):1683-90. PMID: 12782671.
    Citations: 71     Fields:    Translation:AnimalsCells
  143. Kos CH, Karaplis AC, Peng JB, Hediger MA, Goltzman D, Mohammad KS, Guise TA, Pollak MR. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest. 2003 Apr; 111(7):1021-8. PMID: 12671051.
    Citations: 48     Fields:    Translation:Animals
  144. Pollak MR. The genetic basis of FSGS and steroid-resistant nephrosis. Semin Nephrol. 2003 Mar; 23(2):141-6. PMID: 12704574.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  145. Pollak MR. Inherited podocytopathies: FSGS and nephrotic syndrome from a genetic viewpoint. J Am Soc Nephrol. 2002 Dec; 13(12):3016-23. PMID: 12444222.
    Citations: 28     Fields:    Translation:HumansAnimals
  146. Tsukaguchi H, Sudhakar A, Le TC, Nguyen T, Yao J, Schwimmer JA, Schachter AD, Poch E, Abreu PF, Appel GB, Pereira AB, Kalluri R, Pollak MR. NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele. J Clin Invest. 2002 Dec; 110(11):1659-66. PMID: 12464671.
    Citations: 72     Fields:    Translation:HumansCells
  147. Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst. 2001 Dec 19; 93(24):1852-7. PMID: 11752009.
    Citations: 260     Fields:    Translation:HumansCells
  148. Chan TW, Pollak M, Huynh H. Inhibition of insulin-like growth factor signaling pathways in mammary gland by pure antiestrogen ICI 182,780. Clin Cancer Res. 2001 Aug; 7(8):2545-54. PMID: 11489838.
    Citations: 10     Fields:    Translation:AnimalsCells
  149. Jernström H, Deal C, Wilkin F, Chu W, Tao Y, Majeed N, Hudson T, Narod SA, Pollak M. Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women. Cancer Epidemiol Biomarkers Prev. 2001 Apr; 10(4):377-84. PMID: 11319179.
    Citations: 36     Fields:    Translation:HumansCells
  150. Kaplan J, Pollak MR. Familial focal segmental glomerulosclerosis. Curr Opin Nephrol Hypertens. 2001 Mar; 10(2):183-7. PMID: 11224692.
    Citations: 4     Fields:    Translation:HumansAnimals
  151. Jernström H, Chu W, Vesprini D, Tao Y, Majeed N, Deal C, Pollak M, Narod SA. Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk. Mol Genet Metab. 2001 Feb; 72(2):144-54. PMID: 11161840.
    Citations: 26     Fields:    Translation:Humans
  152. Zi X, Zhang J, Agarwal R, Pollak M. Silibinin up-regulates insulin-like growth factor-binding protein 3 expression and inhibits proliferation of androgen-independent prostate cancer cells. Cancer Res. 2000 Oct 15; 60(20):5617-20. PMID: 11059749.
    Citations: 21     Fields:    Translation:HumansCells
  153. Tsukaguchi H, Yager H, Dawborn J, Jost L, Cohlmia J, Abreu PF, Pereira AB, Pollak MR. A locus for adolescent and adult onset familial focal segmental glomerulosclerosis on chromosome 1q25-31. J Am Soc Nephrol. 2000 Sep; 11(9):1674-80. PMID: 10966492.
    Citations: 4     Fields:    Translation:HumansCells
  154. Olszak IT, Poznansky MC, Evans RH, Olson D, Kos C, Pollak MR, Brown EM, Scadden DT. Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo. J Clin Invest. 2000 May; 105(9):1299-305. PMID: 10792005.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  155. Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, Tong HQ, Mathis BJ, Rodríguez-Pérez JC, Allen PG, Beggs AH, Pollak MR. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet. 2000 Mar; 24(3):251-6. PMID: 10700177.
    Citations: 347     Fields:    Translation:HumansCells
  156. Nickerson T, Pollak M. Bicalutamide (Casodex)-induced prostate regression involves increased expression of genes encoding insulin-like growth factor binding proteins. Urology. 1999 Dec; 54(6):1120-5. PMID: 10604720.
    Citations: 10     Fields:    Translation:Animals
  157. Rozen F, Pollak M. Inhibition of insulin-like growth factor I receptor signaling by the vitamin D analogue EB1089 in MCF-7 breast cancer cells: A role for insulin-like growth factor binding proteins. Int J Oncol. 1999 Sep; 15(3):589-94. PMID: 10427145.
    Citations: 7     Fields:    Translation:HumansCells
  158. Gherman RB, Bowen E, Eggleston MK, Teague KE, Sayles T, Brown EM, Pollak MR. Successful pregnancy outcome in a woman with a gain-of-function mutation of the calcium-sensing receptor. A case report. J Reprod Med. 1999 Aug; 44(8):745-7. PMID: 10483549.
    Citations:    Fields:    Translation:Humans
  159. Nickerson T, Miyake H, Gleave ME, Pollak M. Castration-induced apoptosis of androgen-dependent shionogi carcinoma is associated with increased expression of genes encoding insulin-like growth factor-binding proteins. Cancer Res. 1999 Jul 15; 59(14):3392-5. PMID: 10416600.
    Citations: 6     Fields:    Translation:AnimalsCells
  160. Nickerson T, Zhang J, Pollak M. Regression of DMBA-induced breast carcinoma following ovariectomy is associated with increased expression of genes encoding insulin-like growth factor binding proteins. Int J Oncol. 1999 May; 14(5):987-90. PMID: 10200352.
    Citations:    Fields:    Translation:Animals
  161. Rozen F, Zhang J, Pollak M. Antiproliferative action of tumor necrosis factor-alpha on MCF-7 breastcancer cells is associated with increased insulin-like growth factor binding protein-3 accumulation. Int J Oncol. 1998 Oct; 13(4):865-9. PMID: 9735418.
    Citations: 11     Fields:    Translation:HumansCells
  162. Huynh H, Pollak M, Zhang JC. Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089. Int J Oncol. 1998 Jul; 13(1):137-43. PMID: 9625815.
    Citations: 11     Fields:    Translation:HumansCells
  163. Nickerson T, Pollak M, Huynh H. Castration-induced apoptosis in the rat ventral prostate is associated with increased expression of genes encoding insulin-like growth factor binding proteins 2,3,4 and 5. Endocrinology. 1998 Feb; 139(2):807-10. PMID: 9449659.
    Citations: 13     Fields:    Translation:Animals
  164. Mathis BJ, Kim SH, Calabrese K, Haas M, Seidman JG, Seidman CE, Pollak MR. A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13. Kidney Int. 1998 Feb; 53(2):282-6. PMID: 9461087.
    Citations: 9     Fields:    Translation:HumansCells
  165. Brown EM, Pollak M, Hebert SC. The extracellular calcium-sensing receptor: its role in health and disease. Annu Rev Med. 1998; 49:15-29. PMID: 9509247.
    Citations: 32     Fields:    Translation:HumansCells
  166. Pollak M. IGF-I physiology and breast cancer. Recent Results Cancer Res. 1998; 152:63-70. PMID: 9928547.
    Citations: 11     Fields:    Translation:Humans
  167. Huynh H, Pollak M. Stabilization of mammary-derived growth inhibitor messenger RNA by antiestrogens. Clin Cancer Res. 1997 Nov; 3(11):2151-6. PMID: 9815609.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  168. Pollak M. The potential role of somatostatin analogues in breast cancer treatment. Yale J Biol Med. 1997 Sep-Dec; 70(5-6):535-9. PMID: 9825480.
    Citations: 1     Fields:    Translation:Humans
  169. Károlyi L, Ziegler A, Pollak M, Fischbach M, Grzeschik KH, Koch MC, Seyberth HW. Gitelman's syndrome is genetically distinct from other forms of Bartter's syndrome. Pediatr Nephrol. 1996 Oct; 10(5):551-4. PMID: 8897553.
    Citations: 3     Fields:    Translation:Humans
  170. Pollak MR, Delaney VB, Graham RM, Hebert SC. Gitelman's syndrome (Bartter's variant) maps to the thiazide-sensitive cotransporter gene locus on chromosome 16q13 in a large kindred. J Am Soc Nephrol. 1996 Oct; 7(10):2244-8. PMID: 8915985.
    Citations: 4     Fields:    Translation:HumansCells
  171. Bai M, Quinn S, Trivedi S, Kifor O, Pearce SH, Pollak MR, Krapcho K, Hebert SC, Brown EM. Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor. J Biol Chem. 1996 Aug 09; 271(32):19537-45. PMID: 8702647.
    Citations: 59     Fields:    Translation:HumansCells
  172. Pollak MR, Seidman CE, Brown EM. Three inherited disorders of calcium sensing. Medicine (Baltimore). 1996 May; 75(3):115-23. PMID: 8965680.
    Citations: 4     Fields:    Translation:HumansAnimals
  173. Hebert SC, Pollak M, Riccardi D, Brown EM. A Ca(2+)-sensing receptor: from physiology to inherited disorders of calcium homeostasis. Adv Nephrol Necker Hosp. 1996; 25:245-55. PMID: 8717629.
    Citations:    Fields:    Translation:HumansAnimals
  174. Pollak M. Peptide growth factors and breast cancer treatment: recent translational research. Recent Results Cancer Res. 1996; 140:43-9. PMID: 8787075.
    Citations:    Fields:    Translation:Humans
  175. Pollak M. Enhancement of the anti-neoplastic effects of tamoxifen by somatostatin analogues. Digestion. 1996; 57 Suppl 1:29-33. PMID: 8813463.
    Citations: 4     Fields:    Translation:HumansAnimals
  176. Ho C, Conner DA, Pollak MR, Ladd DJ, Kifor O, Warren HB, Brown EM, Seidman JG, Seidman CE. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet. 1995 Dec; 11(4):389-94. PMID: 7493018.
    Citations: 103     Fields:    Translation:HumansAnimals
  177. Hosokawa Y, Pollak MR, Brown EM, Arnold A. Mutational analysis of the extracellular Ca(2+)-sensing receptor gene in human parathyroid tumors. J Clin Endocrinol Metab. 1995 Nov; 80(11):3107-10. PMID: 7593409.
    Citations: