Harvard Catalyst Profiles

Columbia University, College of Physicians and Surgeons	M.D.	1996	Medicine
Yale University	B.S.	1990	Biology
HSPH	Post Doc	2006	Immunology & Infectious Diseases - 5years Postdoctoral Fellow
Brigham and Women’s Hospital		2000	3years Internship/Residency in Internal Medicine
Brigham and Women’s Hospital		2001	1year Clinical Fellowship in Infectious Diseases

My laboratory focuses on the molecular basis of population heterogeneity in Mycobacterium tuberculosis (Mtb) and the extent to which differences between mycobacterial cells contribute to differences in disease and treatment outcomes. Our work combines bacterial genetic approaches with high throughput methodologies including population genomics, ssRNAseq and quantitative live cell imaging to define the molecular mechanisms by which Mtb generates diversity and how this diversity enables the bacterium to survive subsequent selective forces including antibiotics and immune selection. We further seek to understand the impact of host immune responses on the interaction of Mtb with the infected host, again working at both single cell and genomic levels. My work engages a broad network of collaborators including experts in technologies to assess single cell behavior at MIT and MGH, experts in sequencing methodologies at the Broad Institute and experts in human immunology at the Ragon Institute, where I am the outgoing Director of the TB Program.