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Paul Hubert Lerou, M.D.

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Mentoring
DNA Damage Response in Pluripotent Stem Cells
Summer, 05/26/12 - 09/03/12

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00HD061981 (LEROU, PAUL HUBERT) Apr 1, 2011 - Mar 31, 2014
    NIH/NICHD
    Genomic stability of human pluripotent stem cells
    Role: Principal Investigator
  2. K99HD061981 (LEROU, PAUL HUBERT) Sep 1, 2009 - Aug 31, 2011
    NIH/NICHD
    Genomic stability of human pluripotent stem cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Spadafora R, Lu J, Khetani RS, Zhang C, Iberg A, Li H, Shi Y, Lerou PH. Lung-Resident Mesenchymal Stromal Cells Reveal Transcriptional Dynamics of Lung Development in Preterm Infants. Am J Respir Crit Care Med. 2018 Oct 01; 198(7):961-964. PMID: 29757681.
    Citations:    Fields:    
  2. Lu J, Baccei A, Lummertz da Rocha E, Guillermier C, McManus S, Finney LA, Zhang C, Steinhauser ML, Li H, Lerou PH. Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm. Stem Cell Res. 2018 04; 28:48-55. PMID: 29427839.
    Citations:    Fields:    Translation:HumansCells
  3. Wang W, Wang L, Lu J, Siedlak SL, Fujioka H, Liang J, Jiang S, Ma X, Jiang Z, da Rocha EL, Sheng M, Choi H, Lerou PH, Li H, Wang X. The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity. Nat Med. 2016 08; 22(8):869-78. PMID: 27348499.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  4. Lu J, Li H, Baccei A, Sasaki T, Gilbert DM, Lerou PH. Influence of ATM-Mediated DNA Damage Response on Genomic Variation in Human Induced Pluripotent Stem Cells. Stem Cells Dev. 2016 05 01; 25(9):740-7. PMID: 26935587; PMCID: PMC4854209.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun. 2015 Oct 23; 6:8715. PMID: 26493500; PMCID: PMC4620584.
    Citations: 70     Fields:    Translation:HumansCells
  6. Walsh BH, Baumer FM, Bernson-Leung ME, Lerou P, Peters JM. Teaching video neuroimages: nonepileptic myoclonus in a neonate following severe hypoxic-ischemic injury. Neurology. 2015 Mar 24; 84(12):e90. PMID: 25802277.
    Citations: 1     Fields:    Translation:Humans
  7. Gorman BR, Lu J, Baccei A, Lowry NC, Purvis JE, Mangoubi RS, Lerou PH. Multi-scale imaging and informatics pipeline for in situ pluripotent stem cell analysis. PLoS One. 2014; 9(12):e116037. PMID: 25551762; PMCID: PMC4281228.
    Citations: 1     Fields:    Translation:HumansCells
  8. Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. A nontranscriptional role for Oct4 in the regulation of mitotic entry. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15768-73. PMID: 25324523; PMCID: PMC4226071.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Liu JC, Lerou PH, Lahav G. Stem cells: balancing resistance and sensitivity to DNA damage. Trends Cell Biol. 2014 May; 24(5):268-74. PMID: 24721782; PMCID: PMC4342985.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  10. Lu J, Li H, Hu M, Sasaki T, Baccei A, Gilbert DM, Liu JS, Collins JJ, Lerou PH. The distribution of genomic variations in human iPSCs is related to replication-timing reorganization during reprogramming. Cell Rep. 2014 Apr 10; 7(1):70-8. PMID: 24685138; PMCID: PMC4133748.
    Citations: 8     Fields:    Translation:HumansCells
  11. Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol. 2014 Jun; 25(6):1211-25. PMID: 24357672; PMCID: PMC4033376.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  12. Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Agarwal V, Letai A, Lerou PH, Lahav G. High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell. 2013 Oct 03; 13(4):483-91. PMID: 23954752; PMCID: PMC4109647.
    Citations: 46     Fields:    Translation:HumansCells
  13. Cherry AB, Gagne KE, McLoughlin EM, Baccei A, Gorman B, Hartung O, Miller JD, Zhang J, Zon RL, Ince TA, Neufeld EJ, Lerou PH, Fleming MD, Daley GQ, Agarwal S. Induced pluripotent stem cells with a mitochondrial DNA deletion. Stem Cells. 2013 Jul; 31(7):1287-97. PMID: 23400930; PMCID: PMC3692613.
    Citations: 26     Fields:    Translation:HumansCells
  14. Guan X, Yabuuchi A, Huo H, Ginsberg E, Racowsky C, Daley GQ, Lerou PH. Derivation of human embryonic stem cells with NEMO deficiency. Stem Cell Res. 2012 May; 8(3):410-5. PMID: 22284529.
    Citations:    Fields:    Translation:HumansAnimalsCells
  15. Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW. Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19252-7. PMID: 22084091; PMCID: PMC3228440.
    Citations: 30     Fields:    Translation:AnimalsCells
  16. Lerou P. Embryonic stem cell derivation from human embryos. Methods Mol Biol. 2011; 767:31-5. PMID: 21822865.
    Citations: 1     Fields:    Translation:HumansCells
  17. Yabuuchi A, Lerou PH, Daley GQ. Derivation of mouse parthenogenetic embryonic stem cells. Methods in Bioengineering (Yarmush ML, Langer RS, editors). 2008.
  18. Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg E, Racowsky C, Daley GQ. Human embryonic stem cell derivation from poor-quality embryos. Nat Biotechnol. 2008 Feb; 26(2):212-4. PMID: 18223642.
    Citations: 28     Fields:    Translation:HumansCells
  19. Lerou PH, Yabuuchi A, Huo H, Miller JD, Boyer LF, Schlaeger TM, Daley GQ. Derivation and maintenance of human embryonic stem cells from poor-quality in vitro fertilization embryos. Nat Protoc. 2008; 3(5):923-33. PMID: 18451800.
    Citations: 20     Fields:    Translation:HumansCells
  20. Park IH, Lerou PH, Zhao R, Huo H, Daley GQ. Generation of human-induced pluripotent stem cells. Nat Protoc. 2008; 3(7):1180-6. PMID: 18600223.
    Citations: 139     Fields:    Translation:HumansCells
  21. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008 Jan 10; 451(7175):141-6. PMID: 18157115.
    Citations: 1014     Fields:    Translation:HumansAnimalsCells
  22. Lengerke C, Kim K, Lerou P, Daley GQ. Differentiation potential of histocompatible parthenogenetic embryonic stem cells. Ann N Y Acad Sci. 2007 Jun; 1106:209-18. PMID: 17360798.
    Citations: 5     Fields:    Translation:AnimalsCells
  23. Kim K, Lerou P, Yabuuchi A, Lengerke C, Ng K, West J, Kirby A, Daly MJ, Daley GQ. Histocompatible embryonic stem cells by parthenogenesis. Science. 2007 Jan 26; 315(5811):482-6. PMID: 17170255.
    Citations: 46     Fields:    Translation:AnimalsCells
  24. Lerou PH, Daley GQ. Therapeutic potential of embryonic stem cells. Blood Rev. 2005 Nov; 19(6):321-31. PMID: 16275420.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  25. Lerou PH. Lower respiratory tract infections in children. Curr Opin Pediatr. 2001 Apr; 13(2):200-6. PMID: 11317066.
    Citations:    Fields:    Translation:Humans
  26. Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA. t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6413-8. PMID: 9600980; PMCID: PMC27754.
    Citations: 36     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.