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Tarun Singhal, M.D., M.B.,B.S.

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Biography
Harvard Joint Program in Nuclear Medicine, Boston, MAAmerican Board of Nuclear Medicine06/2014Nuclear Medicine
Massachusetts General Hospital, Boston, MAFellowship06/2013Neurology
Harvard Partners Neurology Residency (Brigham and Women's Hospital/Massachusetts General Hospital), Boston, MAAmerican Board of Psychiatry and Neurology06/2012Neurology
Yale-New Haven Hospital, New Haven, CTInternship06/2009Internal Medicine
Yale Positron Emission Tomography Center, New Haven, CTPost-doctoral fellowship06/2008Positron Emission Tomography
Charles F. Kettering Memorial Hospital PET Center, Kettering, OhioPost-doctoral fellowship06/2007Positron Emission Tomography
All India Institute of Medical Sciences, New Delhi, IndiaM.D.06/2006Nuclear Medicine
All India Institute of Medical Sciences, New Delhi, IndiaM.B.B.S.03/2003Medicine
2016
'Race to Erase MS' Young Investigator Award
2011
Boston Society of Neurology and Psychiatry Cobb Assembly Best Paper Award
2010
Radiological Society of North America Molecular Imaging Travel Award
2008
Society of Nuclear Medicine Travel Award
2003
Among top 0.01% in National Post-Graduate Entrance Test
1997
Among top 0.001% in National Pre-Medical Test
1997
First rank in Delhi Pre-Medical Test
1997 - 2002
Honors in Biochemistry, Microbiology, Medicine and Psychiatry
1995 - 2006
National Talent Scholarship, Government of India

Overview
Research Interests: Positron Emission Tomography of neuroinflammation in Multiple Sclerosis, Alzheimer's DIsease, and related disorders; PET/MRI hybrid and correlative imaging; Translational applications of PET imaging in clinical neurology and neuroscience; Clinical Trials in multiple sclerosis

Clinical Interests: Multiple Sclerosis and related disorders; Diagnostic and Therapeutic Nuclear Medicine

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vives-Rodriguez A, Turk KW, Vassey EA, Singhal T, Cho CH, Budson AE. Reversible Amnestic Cognitive Impairment in a Patient With Brain Sagging Syndrome. Neurol Clin Pract. 2021 Aug; 11(4):e551-e554. PMID: 34484956.
    Citations:    
  2. Cicero S, Rissanen E, Carter K, Nguyen H, Petit R, Ellerin TB, Dhillon R, Singhal T. Aseptic Neutrophilic Meningitis With Hypoglycorrhachia Following a Single Ocrelizumab Infusion. Neurol Neuroimmunol Neuroinflamm. 2021 09; 8(5). PMID: 34210799.
    Citations:    Fields:    
  3. Singhal T, Rissanen E, Ficke J, Cicero S, Carter K, Weiner HL. Widespread Glial Activation in Primary Progressive Multiple Sclerosis Revealed by 18F-PBR06 PET: A Clinically Feasible, Individualized Approach. Clin Nucl Med. 2021 Feb 01; 46(2):136-137. PMID: 33208611.
    Citations:    Fields:    Translation:HumansCells
  4. Akbik F, Robertson M, Das AS, Singhal T, Lee JW, Vaitkevicius H. The PET Sandwich: Using Serial FDG-PET Scans with Interval Burst Suppression to Assess Ictal Components of Disease. Neurocrit Care. 2020 12; 33(3):657-669. PMID: 32253731.
    Citations: 1     Fields:    Translation:Humans
  5. Singhal T, Cicero S, Pan H, Carter K, Dubey S, Chu R, Glanz B, Hurwitz S, Tauhid S, Park MA, Kijewski M, Stern E, Bakshi R, Silbersweig D, Weiner HL. Regional microglial activation in the substantia nigra is linked with fatigue in MS. Neurol Neuroimmunol Neuroinflamm. 2020 09 03; 7(5). PMID: 32769103.
    Citations:    Fields:    Translation:HumansCells
  6. Akbik F, Robertson M, Das AS, Singhal T, Lee JW, Vaitkevicius H. Correction to: The PET Sandwich: Using Serial FDG-PET Scans with Interval Burst Suppression to Assess Ictal Components of Disease. Neurocrit Care. 2020 08; 33(1):330-331. PMID: 32378130.
    Citations:    Fields:    
  7. Tavazzi E, Zivadinov R, Dwyer MG, Jakimovski D, Singhal T, Weinstock-Guttman B, Bergsland N. MRI biomarkers of disease progression and conversion to secondary-progressive multiple sclerosis. Expert Rev Neurother. 2020 08; 20(8):821-834. PMID: 32306772.
    Citations: 2     Fields:    Translation:Humans
  8. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Correction to: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 Feb; 26(1):121. PMID: 31515701.
    Citations:    Fields:    
  9. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 02; 26(1):118-120. PMID: 31286440.
    Citations:    Fields:    Translation:Humans
  10. Singhal T, O'Connor K, Dubey S, Pan H, Chu R, Hurwitz S, Cicero S, Tauhid S, Silbersweig D, Stern E, Kijewski M, DiCarli M, Weiner HL, Bakshi R. Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study. Neurol Neuroimmunol Neuroinflamm. 2019 09; 6(5):e587. PMID: 31355321.
    Citations: 4     Fields:    Translation:Humans
  11. Singhal T, O'Connor K, Dubey S, Pan H, Chu R, Hurwitz S, Cicero S, Tauhid S, Silbersweig D, Stern E, Kijewski M, DiCarli M, Weiner HL, Bakshi R. Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study. Neurol Neuroimmunol Neuroinflamm. 2019 Sep; 6(5). PMID: 31454766.
    Citations:    
  12. Singhal T, O'Connor K, Dubey S, Belanger AP, Hurwitz S, Chu R, Tauhid S, Kijewski MF, DiCarli MF, Weiner HL, Bakshi R. 18F-PBR06 Versus 11C-PBR28 PET for Assessing White Matter Translocator Protein Binding in Multiple Sclerosis. Clin Nucl Med. 2018 Sep; 43(9):e289-e295. PMID: 30004939.
    Citations: 8     Fields:    Translation:Humans
  13. Singhal T, Weiner HL, Bakshi R. TSPO-PET Imaging to Assess Cerebral Microglial Activation in Multiple Sclerosis. Semin Neurol. 2017 10; 37(5):546-557. PMID: 29207414.
    Citations: 2     Fields:    Translation:HumansCells
  14. Singhal T, Kim CK. Putaminal Hypometabolism Exceeding Caudate Abnormalities on 18F-FDG PET in Huntington Disease. Clin Nucl Med. 2017 Jul; 42(7):e343-e344. PMID: 28418951.
    Citations: 1     Fields:    Translation:Humans
  15. Tummala S, Singhal T, Oommen VV, Kim G, Khalid F, Healy BC, Bakshi R. Spinal Cord as an Adjunct to Brain Magnetic Resonance Imaging in Defining "No Evidence of Disease Activity" in Multiple Sclerosis. Int J MS Care. 2017 May-Jun; 19(3):158-164. PMID: 28603465.
    Citations: 1     
  16. Singhal T, Tauhid S, Hurwitz S, Neema M, Bakshi R. The Effect of Glatiramer Acetate on Spinal Cord Volume in Relapsing-Remitting Multiple Sclerosis. J Neuroimaging. 2017 01; 27(1):33-36. PMID: 27466943.
    Citations: 5     Fields:    Translation:Humans
  17. Singhal T, Stern E. Biomarkers in Randomized Clinical Trials: Positron Emission Tomography and Nuclear Medicine Techniques. Front Neurol Neurosci. 2016; 39:109-16. PMID: 27463807.
    Citations:    Fields:    Translation:Humans
  18. Agnihotri SP, Singhal T, Stern BJ, Cho TA. Neurosarcoidosis. Semin Neurol. 2014 Sep; 34(4):386-94. PMID: 25369434.
    Citations: 6     Fields:    Translation:Humans
  19. Singhal T, Alavi A, Kim CK. Brain: positron emission tomography tracers beyond [¹8F]fluorodeoxyglucose. PET Clin. 2014 Jul; 9(3):267-76. PMID: 25030390.
    Citations: 3     Fields:    Translation:Humans
  20. Singhal T. The history of cerebral PET scanning: From physiology to cutting-edge technology. Neurology. 2013 Oct 01; 81(14):1275. PMID: 24081964.
    Citations: 1     Fields:    Translation:HumansAnimals
  21. Singhal T, Venna N. Mystery case: frontal meningoencephalocele causing recurrent bacterial meningitis. Neurology. 2013 Jun 11; 80(24):e250. PMID: 23751922.
    Citations:    Fields:    Translation:Humans
  22. Singhal T. Positron emission tomography applications in clinical neurology. Semin Neurol. 2012 Sep; 32(4):421-31. PMID: 23361486.
    Citations: 11     Fields:    Translation:HumansAnimals
  23. Singhal T, Narayanan TK, Jacobs MP, Bal C, Mantil JC. 11C-methionine PET for grading and prognostication in gliomas: a comparison study with 18F-FDG PET and contrast enhancement on MRI. J Nucl Med. 2012 Nov; 53(11):1709-15. PMID: 23055534.
    Citations: 42     Fields:    Translation:Humans
  24. Alfson ED, Awosika OO, Singhal T, Fricchione GL. Lysis of catatonic withdrawal by propofol in a bone-marrow transplant recipient with adenovirus limbic encephalitis. Psychosomatics. 2013 Mar-Apr; 54(2):192-5. PMID: 22705183.
    Citations: 2     Fields:    Translation:HumansCells
  25. Gallezot JD, Beaver JD, Gunn RN, Nabulsi N, Weinzimmer D, Singhal T, Slifstein M, Fowles K, Ding YS, Huang Y, Laruelle M, Carson RE, Rabiner EA. Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo. Synapse. 2012 Jun; 66(6):489-500. PMID: 22213512.
    Citations: 45     Fields:    Translation:AnimalsCells
  26. Singhal T, Ding YS, Weinzimmer D, Normandin MD, Labaree D, Ropchan J, Nabulsi N, Lin SF, Skaddan MB, Soeller WC, Huang Y, Carson RE, Treadway JL, Cline GW. Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes. Mol Imaging Biol. 2011 Oct; 13(5):973-84. PMID: 20824509.
    Citations: 35     Fields:    Translation:Animals
  27. Ding YS, Singhal T, Planeta-Wilson B, Gallezot JD, Nabulsi N, Labaree D, Ropchan J, Henry S, Williams W, Carson RE, Neumeister A, Malison RT. PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT. Synapse. 2010 Jan; 64(1):30-8. PMID: 19728366.
    Citations: 38     Fields:    Translation:Humans
  28. Gallezot JD, Nabulsi N, Neumeister A, Planeta-Wilson B, Williams WA, Singhal T, Kim S, Maguire RP, McCarthy T, Frost JJ, Huang Y, Ding YS, Carson RE. Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans. J Cereb Blood Flow Metab. 2010 Jan; 30(1):196-210. PMID: 19773803.
    Citations: 33     Fields:    Translation:Humans
  29. Singhal T, B. Planeta-Wilson, J. D. Gallezot, S. Henry, N. Nabulsi, D. Labaree, J. Ropchan, R. E. Carson, A. Neumeister and Y. S. Ding. . High resolution parametric mapping of human norepinephrine transporter (NET) system in the brain with (S,S)-[11C]O-methylreboxetine (MRB). JNM. 2008.
  30. Singhal T, Narayanan TK, Jain V, Mukherjee J, Mantil J. 11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas. Mol Imaging Biol. 2008 Jan-Feb; 10(1):1-18. PMID: 17957408.
    Citations: 60     Fields:    Translation:HumansAnimals
  31. Prasad K, Kumar A, Gupta PK, Singhal T. Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis. Cochrane Database Syst Rev. 2007 Oct 17; (4):CD001832. PMID: 17943757.
    Citations: 5     Fields:    Translation:Humans
  32. Tripathi M, Singhal T, Chandrasekhar N, Kumar P, Bal C, Jhulka PK, Bandopadhyaya G, Malhotra A. Samarium-153 ethylenediamine tetramethylene phosphonate therapy for bone pain palliation in skeletal metastases. Indian J Cancer. 2006 Apr-Jun; 43(2):86-92. PMID: 16790946.
    Citations: 11     Fields:    Translation:Humans
  33. Singhal T, Bal CS, Sagar R, Bandopadhyaya GP, Malhotra A. 99mTc ECD Brain SPECT in major depression patients before and after anti-depressant therapy: A Statistical Parametric Mapping study. JNM. 2005.
  34. Barai S, Bandopadhayaya GP, Bhowmik D, Patel CD, Malhotra A, Agarwal P, Singhal T. Prevalence of vesicoureteral reflux in patients with incidentally diagnosed adult hypertension. Urology. 2004 Jun; 63(6):1045-8; discussion 1048-9. PMID: 15183945.
    Citations: 5     Fields:    Translation:Humans
  35. Prasad K, Singhal T, Jain N, Gupta PK. Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis. Cochrane Database Syst Rev. 2004; (2):CD001832. PMID: 15106163.
    Citations:    Fields:    Translation:Humans
  36. Barai S, Kumar R, Mehta SN, Dinda AK, Yadav R, Bandopadhayaya GP, Tarun S, Malhotra A. Diagnostic significance of semiquantitative and quantitative parameters of Tc99m-Ethylenedicystine renal allograft scintigraphy. Int Urol Nephrol. 2003; 35(4):451-6. PMID: 15198143.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.