This study examines the determinants of hypogonadotropic hypogonadism in adolescent and young adult female athletes who develop athletic amenorrhea, and the response of bone density and bone structural parameters to physiologic estrogen replacement.
Students will work on recruitment strategies for the study, conduct of study visits, data collection and management, sample collection and management, and analysis of cross-sectional data. Students will be encouraged to work on study related abstracts for national level meetings and on related manuscripts.
Adolescence and young adulthood are often a time for the onset of eating disorders, as well as a key window of neurocognitive development and hormone changes. Estrogen dysregulation is common in eating disorders and is associated with impaired cognitive flexibility and altered reward responsiveness and valuation, which in turn, may play a mechanistic role in the onset and course of eating disorders. This proposal utilizes physiologic estrogen as a probe, studying its role in cognitive flexibility, reward responsiveness and valuation, and in turn, eating disorder psychopathology, in eating disorders.
The student will work on scoring study instruments, the study database, and recruitment of study participants.
The study aims to examine the impact of Roux-en-Y gastric bypass and vertical sleeve gastrectomy on bone density, geometry, structure and strength estimates in adolescents with severe obesity 14-21 years old, and to understand the mechanisms that underlie these changes.