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Nan McKenzie Laird, Ph.D.

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Harvard UniversityPh.D.1975Statistics
University of GeorgiaB.S.1969Statistics

Nan M. Laird is the Harvey V. Fineberg Professor of Biostatistics (Emerita) at Harvard University. During her more than forty years on the faculty, she developed many simple and practical statistical methods for pressing public health and medical problems. Her work on the EM Algorithm, with Art Dempster and Don Rubin, is among the top 100 most cited of all published articles in science. She has also developed popular and widely used methods for meta-analysis, longitudinal data and statistical genetics. She was awarded the third International Prize in Statistics in 2021 for her work on longitudinal data (joint with Jim Ware). She has worked in several areas of applications, including the quantification of adverse events in hospitals, childhood obesity, and genetic studies in Alzheimer's disease, bipolar disorder, asthma and lung disease. She has supervised over 30 doctoral and postdoctoral fellows at Harvard Biostatistics, and written two books widely used as texts, one on longitudinal data analysis with Garrett Fitzmaurice and Jim Ware, and another on the statistical analysis of genetic data with Christoph Lange. She has served on numerous committees for the NIH and NSF, including a National Academy of Sciences Committee on Cabin Air Quality which recommended the current ban on smoking in airplanes. She has received numerous awards including the 2011 Samuel S. Wilks Award from the American Statistical Association, the 25th Annual Lowell Reed Lecturer from the American Public Health Association in 2011, and the 2015 Marvin Zelen Award for Leadership in the Statistical Sciences.

Statistical methods for the analysis of data collected in public health and medical investigations, including:
Missing or incomplete observations
Data collected on individuals repeatedly, or over time
Health outcomes or exposures measured by multiple sources or Informants
Random Effects models for analysis of complex-multisource data
Combining the results of separate but parallel investigations, e. g. meta-analysis and Empirical Bayes
Statistical methods studying association between genetic variants and disease, especially using data from families

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH059532 (LAIRD, NAN MCKENZIE) Sep 30, 1998 - Feb 29, 2012
    Family Based Tests of Association for Complex Diseases
    Role: Principal Investigator
  2. R01MH054693 (NORMAND, SHARON-LISE TERESA) Aug 1, 1996 - Dec 31, 2012
    Analysis of Multiple Informant Data in Psychiatry
    Role: Co-Principal Investigator
  3. T32MH017119 (KOENEN, KARESTAN C) Jul 1, 1983 - Jun 30, 2025
    Training Program in Psychiatric Genetics and Translational Research
    Role: Co-Principal Investigator
  4. N01DK032241 (LAIRD, NAN M) Mar 1, 1983
    Role: Principal Investigator
  5. R01GM029745 (FITZMAURICE, GARRETT M) Sep 1, 1981 - Jan 31, 2007
    Methods for the Analysis of Longitudinal Data
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 Jun 22. PMID: 34159627.
    Citations:    Fields:    
  2. Parsons AA, Leggett D, Vollmer D, Perez V, Smith R, Goodman E, Mayes C, McLellan C, Laird N, Beck AF, Kahn R, Riley C. Cultivating social relationships and disrupting social isolation in low-income, high-disparity neighbourhoods in Ohio, USA. Health Soc Care Community. 2021 Feb 09. PMID: 33560567.
    Citations:    Fields:    
  3. Hecker J, William Townes F, Kachroo P, Laurie C, Lasky-Su J, Ziniti J, Cho MH, Weiss ST, Laird NM, Lange C. A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests. Bioinformatics. 2020 Dec 26. PMID: 33367522.
    Citations: 1     Fields:    
  4. Hecker J, Laird N, Lange C. A comparison of popular TDT-generalizations for family-based association analysis. Genet Epidemiol. 2019 04; 43(3):300-317. PMID: 30609057.
    Citations: 1     Fields:    Translation:Humans
  5. Hecker J, Xu X, Townes FW, Loehlein Fier H, Corcoran C, Laird N, Lange C. Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm. Genet Epidemiol. 2018 02; 42(1):123-126. PMID: 29159827.
    Citations: 2     Fields:    Translation:Humans
  6. Sato Y, Gosho M, Nagashima K, Takahashi S, Ware JH, Laird NM. Statistical Methods in the Journal - An Update. N Engl J Med. 2017 03 16; 376(11):1086-1087. PMID: 28296608.
    Citations: 7     Fields:    
  7. Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771. PMID: 27669027.
    Citations: 18     Fields:    Translation:Humans
  8. Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341. PMID: 27854507.
    Citations: 12     Fields:    Translation:Humans
  9. Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 05; 41(4):309-319. PMID: 28191685.
    Citations: 6     Fields:    Translation:Humans
  10. Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agustí A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH. Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 01; 194(1):48-57. PMID: 26771213.
    Citations: 25     Fields:    Translation:Humans
  11. Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138. PMID: 26634245.
    Citations: 54     Fields:    Translation:HumansCellsCTClinical Trials
  12. Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San José Estépar R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):559-69. PMID: 26030696.
    Citations: 59     Fields:    Translation:Humans
  13. Zhou JJ, Cho MH, Lange C, Lutz S, Silverman EK, Laird NM. Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered. 2015; 79(2):93-104. PMID: 26111731.
    Citations: 9     Fields:    Translation:Humans
  14. Yip WK, Fier H, DeMeo DL, Aryee M, Laird N, Lange C. A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol. 2014 Dec; 38(8):714-21. PMID: 25250875.
    Citations: 2     Fields:    Translation:HumansCells
  15. Chu JH, Hersh CP, Castaldi PJ, Cho MH, Raby BA, Laird N, Bowler R, Rennard S, Loscalzo J, Quackenbush J, Silverman EK. Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol. 2014 Jun 25; 8:78. PMID: 24964944.
    Citations: 15     Fields:    Translation:Humans
  16. Zhou JJ, Yip WK, Cho MH, Qiao D, McDonald ML, Laird NM. A comparative analysis of family-based and population-based association tests using whole genome sequence data. BMC Proc. 2014; 8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S33. PMID: 25519381.
    Citations: 5     
  17. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25. PMID: 24621683.
    Citations: 134     Fields:    Translation:Humans
  18. Zhou JJ, Cho MH, Castaldi PJ, Hersh CP, Silverman EK, Laird NM. Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med. 2013 Oct 15; 188(8):941-7. PMID: 23972146.
    Citations: 46     Fields:    Translation:Humans
  19. Moreno-Macías H, Dockery DW, Schwartz J, Gold DR, Laird NM, Sienra-Monge JJ, Del Río-Navarro BE, Ramírez-Aguilar M, Barraza-Villarreal A, Li H, London SJ, Romieu I. Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study. Respir Res. 2013 Feb 04; 14:14. PMID: 23379631.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  20. De G, Yip WK, Ionita-Laza I, Laird N. Rare variant analysis for family-based design. PLoS One. 2013; 8(1):e48495. PMID: 23341868.
    Citations: 49     Fields:    Translation:Humans
  21. Field AE, Sonneville KR, Micali N, Crosby RD, Swanson SA, Laird NM, Treasure J, Solmi F, Horton NJ. Prospective association of common eating disorders and adverse outcomes. Pediatrics. 2012 Aug; 130(2):e289-95. PMID: 22802602.
    Citations: 52     Fields:    Translation:Humans
  22. Adhikari K, AlChawa T, Ludwig K, Mangold E, Laird N, Lange C. Is it rare or common? Genet Epidemiol. 2012 Jul; 36(5):419-29. PMID: 22549767.
    Citations: 1     Fields:    Translation:Humans
  23. Yip WK, De G, Raby BA, Laird N. Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set. BMC Proc. 2011 Nov 29; 5 Suppl 9:S21. PMID: 22373204.
    Citations: 11     
  24. Yan A, Laird NM, Li C. Identifying rare variants using a Bayesian regression approach. BMC Proc. 2011 Nov 29; 5 Suppl 9:S99. PMID: 22373362.
    Citations: 2     
  25. Sebro R, Lange C, Laird NM, Rogus JJ, Risch NJ. Differentiating population stratification from genotyping error using family data. Ann Hum Genet. 2012 Jan; 76(1):42-52. PMID: 22111716.
    Citations: 1     Fields:    Translation:Humans
  26. Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1147-53. PMID: 21659657.
    Citations: 39     Fields:    Translation:HumansCellsCTClinical Trials
  27. Yoon FB, Fitzmaurice GM, Lipsitz SR, Horton NJ, Laird NM, Normand SL. Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case study. Stat Med. 2011 Jul 20; 30(16):1917-32. PMID: 21538986.
    Citations: 6     Fields:    Translation:Humans
  28. Javaras KN, Goldsmith HH, Laird NM. Estimating the effect of a predictor measured by two informants on a continuous outcome: a comparison of methods. Epidemiology. 2011 May; 22(3):390-9. PMID: 21403520.
    Citations: 1     Fields:    Translation:Humans
  29. Howrigan DP, Laird NM, Smoller JW, Devlin B, McQueen MB. Using linkage information to weight a genome-wide association of bipolar disorder. . 2011 Jun; 156B(4):462-71. PMID: 21480485.
    Citations: 2     Translation:HumansCells
  30. Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70. PMID: 21401569.
    Citations: 2     Fields:    Translation:Humans
  31. Ionita-Laza I, Buxbaum JD, Laird NM, Lange C. A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet. 2011 Feb 03; 7(2):e1001289. PMID: 21304886.
    Citations: 89     Fields:    Translation:Humans
  32. Sato Y, Yamamoto N, Kunitoh H, Ohe Y, Minami H, Laird NM, Katori N, Saito Y, Ohnami S, Sakamoto H, Sawada J, Saijo N, Yoshida T, Tamura T. Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. J Thorac Oncol. 2011 Jan; 6(1):132-8. PMID: 21079520.
    Citations: 18     Fields:    Translation:Humans
  33. Sinha SK, Laird NM, Fitzmaurice GM. Multivariate logistic regression with incomplete covariate and auxiliary information. J Multivar Anal. 2010 Nov 01; 101(10):2389-2397. PMID: 20953361.
    Citations: 1     
  34. Ionita-Laza I, Laird NM. On the optimal design of genetic variant discovery studies. Stat Appl Genet Mol Biol. 2010; 9:Article33. PMID: 20812911.
    Citations: 7     Fields:    Translation:Humans
  35. VanderWeele TJ, Laird NM. Tests for compositional epistasis under single interaction-parameter models. Ann Hum Genet. 2011 Jan; 75(1):146-56. PMID: 20726965.
    Citations: 9     Fields:    Translation:Humans
  36. Moreno-Macias H, Romieu I, London SJ, Laird NM. Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. Hum Genomics. 2010 Jun; 4(5):302-26. PMID: 20650819.
    Citations: 4     Fields:    Translation:Humans
  37. Laird N, Fitzmaurice G, Ding X. Comments on 'Empirical vs natural weighting in random effects meta-analysis'. Stat Med. 2010 May 30; 29(12):1266-7; discussion 1272-81. PMID: 20499329.
    Citations: 4     Fields:    Translation:Humans
  38. Javaras KN, Hudson JI, Laird NM. Fitting ACE structural equation models to case-control family data. Genet Epidemiol. 2010 Apr; 34(3):238-45. PMID: 19918760.
    Citations: 6     Fields:    Translation:Humans
  39. Cho MH, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N, Reilly JJ, Silverman EK. Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. Respir Res. 2010 Mar 16; 11:30. PMID: 20233420.
    Citations: 25     Fields:    Translation:Humans
  40. Fan J, Ionita-Laza I, McQueen MB, Devlin B, Purcell S, Faraone SV, Allen MH, Bowden CL, Calabrese JR, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TB, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel JK, Sachs GS, Thase ME, Molay FB, Escamilla MA, Nimgaonkar VL, Sklar P, Laird NM, Smoller JW. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. . 2010 Jan 05; 153B(1):29-37. PMID: 19308960.
    Citations: 7     Translation:HumansCells
  41. Sato Y, Laird NM, Yoshida T. Biostatistic tools in pharmacogenomics--advances, challenges, potential. Curr Pharm Des. 2010; 16(20):2232-40. PMID: 20459388.
    Citations: 4     Fields:    Translation:Humans
  42. Louicharoen C, Patin E, Paul R, Nuchprayoon I, Witoonpanich B, Peerapittayamongkol C, Casademont I, Sura T, Laird NM, Singhasivanon P, Quintana-Murci L, Sakuntabhai A. Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians. Science. 2009 Dec 11; 326(5959):1546-9. PMID: 20007901.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  43. Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103. PMID: 19996607.
    Citations: 1     Fields:    Translation:Humans
  44. Hoffmann TJ, Lange C, Vansteelandt S, Laird NM. Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol. 2009 Dec; 33(8):691-9. PMID: 19365860.
    Citations: 18     Fields:    Translation:Humans
  45. Sato Y, Laird N, Suganami H, Hamada C, Niki N, Yoshimura I, Yoshida T. Statistical screening method for genetic factors influencing susceptibility to common diseases in a two-stage genome-wide association study. Stat Appl Genet Mol Biol. 2009; 8:Article 46. PMID: 19954418.
    Citations:    Fields:    Translation:Humans
  46. Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, Montrose D, Fagiolini A, Friedman ES, Allen MH, Bowden CL, Calabrese J, El-Mallakh RS, Escamilla M, Faraone SV, Fossey MD, Gyulai L, Loftis JM, Hauser P, Ketter TA, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Laird N, Keshavan M, Thase ME, Axelson D, Birmaher B, Lewis D, Monk T, Frank E, Kupfer DJ, Devlin B, Nimgaonkar VL. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009 Nov; 11(7):701-10. PMID: 19839995.
    Citations: 55     Fields:    Translation:Humans
  47. Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 2009 Oct; 5(10):e1000694. PMID: 19851442.
    Citations: 25     Fields:    Translation:Humans
  48. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird NM, Khuhaprema T, Brennan P, Boffetta P, Yoshida T. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer. 2009 Aug 15; 125(4):837-43. PMID: 19415745.
    Citations: 33     Fields:    Translation:Humans
  49. Javaras KN, Laird NM, Hudson JI, Ripley BD. Estimating disease prevalence using relatives of case and control probands. Biometrics. 2010 Mar; 66(1):214-21. PMID: 19459833.
    Citations: 5     Fields:    Translation:Humans
  50. Ding X, Laird N. Family-Based Association Tests with longitudinal measurements: handling missing data. Hum Hered. 2009; 68(2):98-105. PMID: 19365136.
    Citations: 1     Fields:    Translation:Humans
  51. Hoffmann TJ, Laird NM. fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages. J Stat Softw. 2009 Apr 01; 30(2). PMID: 21625291.
    Citations: 5     
  52. Ding X, Weiss S, Raby B, Lange C, Laird NM. Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol. 2009; 8:Article 17. PMID: 19222384.
    Citations: 2     Fields:    Translation:Humans
  53. Murphy JM, Horton NJ, Burke JD, Monson RR, Laird NM, Lesage A, Sobol AM. Obesity and weight gain in relation to depression: findings from the Stirling County Study. Int J Obes (Lond). 2009 Mar; 33(3):335-41. PMID: 19139752.
    Citations: 19     Fields:    Translation:Humans
  54. Sato Y, Laird NM, Nagashima K, Kato R, Hamano T, Yafune A, Kaniwa N, Saito Y, Sugiyama E, Kim SR, Furuse J, Ishii H, Ueno H, Okusaka T, Saijo N, Sawada JI, Yoshida T. A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies. Pharmacogenomics J. 2009 Apr; 9(2):137-46. PMID: 19104505.
    Citations: 2     Fields:    Translation:Humans
  55. Lasky-Su J, Anney RJ, Neale BM, Franke B, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C, Faraone SV. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. . 2008 Dec 05; 147B(8):1355-8. PMID: 18937294.
    Citations: 46     Translation:Humans
  56. Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV. Genome-wide association scan of attention deficit hyperactivity disorder. . 2008 Dec 05; 147B(8):1337-44. PMID: 18980221.
    Citations: 101     Translation:Humans
  57. Lasky-Su J, Neale BM, Franke B, Anney RJ, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C, Faraone SV. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. . 2008 Dec 05; 147B(8):1345-54. PMID: 18821565.
    Citations: 151     Translation:Humans
  58. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32. PMID: 18976728.
    Citations: 204     Fields:    Translation:HumansCells
  59. Ding X, Lange C, Xu X, Laird N. New powerful approaches for family-based association tests with longitudinal measurements. Ann Hum Genet. 2009 Jan; 73(1):74-83. PMID: 18798838.
    Citations: 6     Fields:    Translation:Humans
  60. Ionita-Laza I, Laird NM, Raby BA, Weiss ST, Lange C. On the frequency of copy number variants. Bioinformatics. 2008 Oct 15; 24(20):2350-5. PMID: 18689430.
    Citations: 3     Fields:    Translation:Humans
  61. Field AE, Javaras KM, Aneja P, Kitos N, Camargo CA, Taylor CB, Laird NM. Family, peer, and media predictors of becoming eating disordered. Arch Pediatr Adolesc Med. 2008 Jun; 162(6):574-9. PMID: 18524749.
    Citations: 41     Fields:    Translation:Humans
  62. Hudson JI, Javaras KN, Laird NM, VanderWeele TJ, Pope HG, Hernán MA. A structural approach to the familial coaggregation of disorders. Epidemiology. 2008 May; 19(3):431-9. PMID: 18379420.
    Citations: 13     Fields:    Translation:Humans
  63. Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST, Lange C. On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol. 2008 Apr; 32(3):273-84. PMID: 18228561.
    Citations: 33     Fields:    Translation:Humans
  64. Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, Illig T, Fox CS, Levy D, Laird N, Ding X, McQueen MB, Butler J, Ardlie K, Papoutsakis C, Dedoussis G, O'Donnell CJ, Wichmann HE, Celedón JC, Schadt E, Hirschhorn J, Weiss ST, Stefansson K, Lange C. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58. PMID: 18387595.
    Citations: 72     Fields:    Translation:Humans
  65. Rakovski CS, Weiss ST, Laird NM, Lange C. FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Hum Hered. 2008; 66(2):122-6. PMID: 18382091.
    Citations: 2     Fields:    Translation:Humans
  66. Murphy JM, Burke JD, Monson RR, Horton NJ, Laird NM, Lesage A, Sobol AM, Leighton AH. Mortality associated with depression: a forty-year perspective from the Stirling County Study. Soc Psychiatry Psychiatr Epidemiol. 2008 Aug; 43(8):594-601. PMID: 18327523.
    Citations: 16     Fields:    Translation:Humans
  67. Javaras KN, Laird NM, Reichborn-Kjennerud T, Bulik CM, Pope HG, Hudson JI. Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study. Int J Eat Disord. 2008 Mar; 41(2):174-9. PMID: 18095307.
    Citations: 42     Fields:    Translation:Humans
  68. Javaras KN, Pope HG, Lalonde JK, Roberts JL, Nillni YI, Laird NM, Bulik CM, Crow SJ, McElroy SL, Walsh BT, Tsuang MT, Rosenthal NR, Hudson JI. Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry. 2008 Feb; 69(2):266-73. PMID: 18348600.
    Citations: 70     Fields:    Translation:Humans
  69. Lasky-Su J, Lange C, Biederman J, Tsuang M, Doyle AE, Smoller JW, Laird N, Faraone S. Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. . 2008 Jan 05; 147B(1):100-6. PMID: 17579349.
    Citations: 15     Translation:Humans
  70. Laird NM, Lange C. Family-based methods for linkage and association analysis. Adv Genet. 2008; 60:219-52. PMID: 18358323.
    Citations: 33     Fields:    Translation:Humans
  71. Schneiter K, Degnan JH, Corcoran C, Xu X, Laird N. EFBAT: exact family-based association tests. BMC Genet. 2007 Dec 20; 8:86. PMID: 18096066.
    Citations: 2     Fields:    Translation:HumansCells
  72. Ionita-Laza I, McQueen MB, Laird NM, Lange C. Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet. 2007 Sep; 81(3):607-14. PMID: 17701906.
    Citations: 50     Fields:    Translation:Humans
  73. Harezlak J, Coull BA, Laird NM, Magari SR, Christiani DC. Penalized solutions to functional regression problems. Comput Stat Data Anal. 2007 Jun 15; 51(10):4911-4925. PMID: 18552972.
    Citations: 5     
  74. Lasky-Su J, Biederman J, Laird N, Tsuang M, Doyle AE, Smoller JW, Lange C, Faraone SV. Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. Ann Hum Genet. 2007 Sep; 71(Pt 5):648-59. PMID: 17501935.
    Citations: 6     Fields:    Translation:Humans
  75. Harezlak J, Naumova E, Laird NM. LongCriSP: a test for bump hunting in longitudinal data. Stat Med. 2007 Mar 15; 26(6):1383-97. PMID: 16850452.
    Citations: 2     Fields:    Translation:Humans
  76. Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros ME, Avila L, Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61. PMID: 17465681.
    Citations: 66     Fields:    Translation:Humans
  77. McQueen MB, Weiss S, Laird NM, Lange C. On the parsing of statistical information in family-based association testing. Nat Genet. 2007 Mar; 39(3):281-2. PMID: 17325672.
    Citations: 1     Fields:    Translation:Humans
  78. Litman HJ, Horton NJ, Hernández B, Laird NM. Incorporating missingness for estimation of marginal regression models with multiple source predictors. Stat Med. 2007 Feb 28; 26(5):1055-68. PMID: 16755531.
    Citations: 8     Fields:    Translation:Humans
  79. Lasky-Su J, Faraone SV, Lange C, Tsuang MT, Doyle AE, Smoller JW, Laird NM, Biederman J. A study of how socioeconomic status moderates the relationship between SNPs encompassing BDNF and ADHD symptom counts in ADHD families. Behav Genet. 2007 May; 37(3):487-97. PMID: 17216343.
    Citations: 16     Fields:    Translation:Humans
  80. Rakovski CS, Xu X, Lazarus R, Blacker D, Laird NM. A new multimarker test for family-based association studies. Genet Epidemiol. 2007 Jan; 31(1):9-17. PMID: 17086514.
    Citations: 23     Fields:    Translation:Humans
  81. Van Steen K, Laird NM, Markel P, Molenberghs G. Approaches to handling incomplete data in family-based association testing. Ann Hum Genet. 2007 Mar; 71(Pt 2):141-51. PMID: 17096676.
    Citations: 1     Fields:    Translation:Humans
  82. Xu X, Rakovski C, Xu X, Laird N. An efficient family-based association test using multiple markers. Genet Epidemiol. 2006 Nov; 30(7):620-6. PMID: 16868964.
    Citations: 15     Fields:    Translation:Humans
  83. Litman HJ, Horton NJ, Murphy JM, Laird NM. Marginal regression models with a time to event outcome and discrete multiple source predictors. Lifetime Data Anal. 2006 Sep; 12(3):249-65. PMID: 17021951.
    Citations:    Fields:    Translation:Humans
  84. Laird NM, Lange C. Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet. 2006 May; 7(5):385-94. PMID: 16619052.
    Citations: 156     Fields:    Translation:Humans
  85. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF. A common genetic variant is associated with adult and childhood obesity. Science. 2006 Apr 14; 312(5771):279-83. PMID: 16614226.
    Citations: 237     Fields:    Translation:Humans
  86. McQueen MB, Blacker D, Laird NM. Variance calculations for identity-by-descent estimation. Am J Hum Genet. 2006 Jun; 78(6):914-21. PMID: 16685643.
    Citations: 2     Fields:    Translation:Humans
  87. Wang L, Wang X, Laird N, Zuckerman B, Stubblefield P, Xu X. Polymorphism in maternal LRP8 gene is associated with fetal growth. Am J Hum Genet. 2006 May; 78(5):770-777. PMID: 16642433.
    Citations: 23     Fields:    Translation:Humans
  88. Hudson JI, Lalonde JK, Berry JM, Pindyck LJ, Bulik CM, Crow SJ, McElroy SL, Laird NM, Tsuang MT, Walsh BT, Rosenthal NR, Pope HG. Binge-eating disorder as a distinct familial phenotype in obese individuals. Arch Gen Psychiatry. 2006 Mar; 63(3):313-9. PMID: 16520437.
    Citations: 50     Fields:    Translation:Humans
  89. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu X. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006 Jan; 83(1):146-54. PMID: 16400063.
    Citations: 167     Fields:    Translation:Humans
  90. McQueen MB, Murphy A, Kraft P, Su J, Lazarus R, Laird NM, Lange C, Van Steen K. Comparison of linkage and association strategies for quantitative traits using the COGA dataset. BMC Genet. 2005 Dec 30; 6 Suppl 1:S96. PMID: 16451712.
    Citations:    Fields:    Translation:HumansCells
  91. Murphy A, McQueen MB, Su J, Kraft P, Lazarus R, Laird NM, Lange C, Van Steen K. Genomic screening in family-based association testing. BMC Genet. 2005 Dec 30; 6 Suppl 1:S115. PMID: 16451572.
    Citations: 2     Fields:    Translation:Humans
  92. Field AE, Austin SB, Striegel-Moore R, Taylor CB, Camargo CA, Laird N, Colditz G. Weight concerns and weight control behaviors of adolescents and their mothers. Arch Pediatr Adolesc Med. 2005 Dec; 159(12):1121-6. PMID: 16330734.
    Citations: 10     Fields:    Translation:Humans
  93. Schneiter K, Laird N, Corcoran C. Exact family-based association tests for biallelic data. Genet Epidemiol. 2005 Nov; 29(3):185-94. PMID: 16094642.
    Citations: 5     Fields:    Translation:Humans
  94. Hsu YH, Niu T, Terwedow HA, Xu X, Feng Y, Li Z, Brain JD, Rosen CJ, Laird N, Xu X. Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet. 2006 Jan; 118(5):568-77. PMID: 16249885.
    Citations: 36     Fields:    Translation:Humans
  95. McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP, Laird NM. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95. PMID: 16175504.
    Citations: 71     Fields:    Translation:HumansCells
  96. Smoller JW, Yamaki LH, Fagerness JA, Biederman J, Racette S, Laird NM, Kagan J, Snidman N, Faraone SV, Hirshfeld-Becker D, Tsuang MT, Slaugenhaupt SA, Rosenbaum JF, Sklar PB. The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder. Biol Psychiatry. 2005 Jun 15; 57(12):1485-92. PMID: 15953484.
    Citations: 44     Fields:    Translation:Humans
  97. Van Steen K, McQueen MB, Herbert A, Raby B, Lyon H, Demeo DL, Murphy A, Su J, Datta S, Rosenow C, Christman M, Silverman EK, Laird NM, Weiss ST, Lange C. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91. PMID: 15937480.
    Citations: 89     Fields:    Translation:Humans
  98. Hersh CP, Demeo DL, Lange C, Litonjua AA, Reilly JJ, Kwiatkowski D, Laird N, Sylvia JS, Sparrow D, Speizer FE, Weiss ST, Silverman EK. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8. PMID: 15817713.
    Citations: 67     Fields:    Translation:HumansCells
  99. Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K, Patterson N. No bias in linkage analysis. Am J Hum Genet. 2004 Oct; 75(4):722-3; author reply 723-7. PMID: 15338460.
    Citations: 1     Fields:    Translation:Humans
  100. Lange C, van Steen K, Andrew T, Lyon H, DeMeo DL, Raby B, Murphy A, Silverman EK, MacGregor A, Weiss ST, Laird NM. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17. PMID: 16646795.
    Citations: 50     Fields:    
  101. Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56. PMID: 15175276.
    Citations: 84     Fields:    Translation:HumansCells
  102. Feng Y, Niu T, Xing H, Xu X, Chen C, Peng S, Wang L, Laird N, Xu X. A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet. 2004 Jul; 75(1):112-21. PMID: 15154117.
    Citations: 78     Fields:    Translation:Humans
  103. Murphy JM, Horton NJ, Laird NM, Monson RR, Sobol AM, Leighton AH. Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution, and comorbidity. Acta Psychiatr Scand. 2004 May; 109(5):355-75. PMID: 15049772.
    Citations: 23     Fields:    Translation:Humans
  104. Brennan TA, Leape LL, Laird NM, Hebert L, Localio AR, Lawthers AG, Newhouse JP, Weiler PC, Hiatt HH. Incidence of adverse events and negligence in hospitalized patients: results of the Harvard Medical Practice Study I. 1991. Qual Saf Health Care. 2004 Apr; 13(2):145-51; discussion 151-2. PMID: 15069223.
    Citations: 89     Fields:    Translation:Humans
  105. Hao K, Wang X, Niu T, Xu X, Li A, Chang W, Wang L, Li G, Laird N, Xu X. A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods. Hum Mol Genet. 2004 Apr 01; 13(7):683-91. PMID: 14976157.
    Citations: 27     Fields:    Translation:Humans
  106. Field AE, Manson JE, Laird N, Williamson DF, Willett WC, Colditz GA. Weight cycling and the risk of developing type 2 diabetes among adult women in the United States. Obes Res. 2004 Feb; 12(2):267-74. PMID: 14981219.
    Citations: 31     Fields:    Translation:Humans
  107. Lyon H, Lange C, Lake S, Silverman EK, Randolph AG, Kwiatkowski D, Raby BA, Lazarus R, Weiland KM, Laird N, Weiss ST. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004 Feb; 26(2):155-65. PMID: 14748015.
    Citations: 36     Fields:    Translation:HumansCells
  108. Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM. PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9. PMID: 14740322.
    Citations: 128     Fields:    Translation:Humans
  109. Lange C, Blacker D, Laird NM. Family-based association tests for survival and times-to-onset analysis. Stat Med. 2004 Jan 30; 23(2):179-89. PMID: 14716720.
    Citations: 21     Fields:    Translation:Humans
  110. Lake SL, Laird NM. Tests of gene-environment interaction for case-parent triads with general environmental exposures. Ann Hum Genet. 2004 Jan; 68(Pt 1):55-64. PMID: 14748830.
    Citations: 22     Fields:    Translation:HumansPHPublic Health
  111. Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol. 2004 Jan; 26(1):61-9. PMID: 14691957.
    Citations: 168     Fields:    Translation:Humans
  112. Hao K, Xu X, Laird N, Wang X, Xu X. Power estimation of multiple SNP association test of case-control study and application. Genet Epidemiol. 2004 Jan; 26(1):22-30. PMID: 14691954.
    Citations: 16     Fields:    Translation:Humans
  113. Smoller JW, Rosenbaum JF, Biederman J, Kennedy J, Dai D, Racette SR, Laird NM, Kagan J, Snidman N, Hirshfeld-Becker D, Tsuang MT, Sklar PB, Slaugenhaupt SA. Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. Biol Psychiatry. 2003 Dec 15; 54(12):1376-81. PMID: 14675801.
    Citations: 37     Fields:    Translation:Humans
  114. Silverman EK, Kwiatkowski DJ, Sylvia JS, Lazarus R, Drazen JM, Lange C, Laird NM, Weiss ST. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol. 2003 Nov; 112(5):870-6. PMID: 14610472.
    Citations: 39     Fields:    Translation:HumansCTClinical Trials
  115. Field AE, Laird N, Steinberg E, Fallon E, Semega-Janneh M, Yanovski JA. Which metric of relative weight best captures body fatness in children? Obes Res. 2003 Nov; 11(11):1345-52. PMID: 14627755.
    Citations: 30     Fields:    Translation:Humans
  116. Mangweth B, Hudson JI, Pope HG, Hausmann A, De Col C, Laird NM, Beibl W, Tsuang MT. Family study of the aggregation of eating disorders and mood disorders. Psychol Med. 2003 Oct; 33(7):1319-23. PMID: 14580085.
    Citations: 9     Fields:    Translation:Humans
  117. Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11. PMID: 14502464.
    Citations: 33     Fields:    Translation:Humans
  118. Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet. 2003 Nov 01; 12(21):2765-76. PMID: 12966032.
    Citations: 15     Fields:    Translation:HumansCells
  119. Murphy JM, Horton NJ, Monson RR, Laird NM, Sobol AM, Leighton AH. Cigarette smoking in relation to depression: historical trends from the Stirling County Study. Am J Psychiatry. 2003 Sep; 160(9):1663-9. PMID: 12944343.
    Citations: 51     Fields:    Translation:Humans
  120. Slasor P, Laird N. Joint models for efficient estimation in proportional hazards regression models. Stat Med. 2003 Jul 15; 22(13):2137-48. PMID: 12820279.
    Citations: 1     Fields:    Translation:HumansCells
  121. Laird NM, Cuenco KT. Regression methods for assessing familial aggregation of disease. Stat Med. 2003 May 15; 22(9):1447-55. PMID: 12704608.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  122. Yang Q, Xu X, Laird N. Power evaluations for family-based tests of association with incomplete parental genotypes. Genetics. 2003 May; 164(1):399-406. PMID: 12750350.
    Citations: 4     Fields:    
  123. Lange C, Silverman EK, Xu X, Weiss ST, Laird NM. A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics. 2003 Apr; 4(2):195-206. PMID: 12925516.
    Citations: 93     Fields:    Translation:Humans
  124. Hudson JI, Mangweth B, Pope HG, De Col C, Hausmann A, Gutweniger S, Laird NM, Biebl W, Tsuang MT. Family study of affective spectrum disorder. Arch Gen Psychiatry. 2003 Feb; 60(2):170-7. PMID: 12578434.
    Citations: 33     Fields:    Translation:Humans
  125. Lake SL, Lyon H, Tantisira K, Silverman EK, Weiss ST, Laird NM, Schaid DJ. Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered. 2003; 55(1):56-65. PMID: 12890927.
    Citations: 166     Fields:    Translation:Humans
  126. Lange C, DeMeo DL, Laird NM. Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet. 2002 Dec; 71(6):1330-41. PMID: 12454799.
    Citations: 59     Fields:    Translation:Humans
  127. DeMeo DL, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird N, Weiss ST. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48. PMID: 12432502.
    Citations: 23     Fields:    Translation:HumansCells
  128. Lange C, Laird NM. Power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet. 2002 Sep; 71(3):575-84. PMID: 12181775.
    Citations: 46     Fields:    Translation:Humans
  129. Lange C, Laird NM. On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol. 2002 Aug; 23(2):165-80. PMID: 12214309.
    Citations: 50     Fields:    Translation:Humans
  130. Murphy JM, Nierenberg AA, Laird NM, Monson RR, Sobol AM, Leighton AH. Incidence of major depression: prediction from subthreshold categories in the Stirling County Study. J Affect Disord. 2002 Apr; 68(2-3):251-9. PMID: 12063153.
    Citations: 7     Fields:    Translation:Humans
  131. Pauler DK, Laird NM. Non-linear hierarchical models for monitoring compliance. Stat Med. 2002 Jan 30; 21(2):219-29. PMID: 11782061.
    Citations: 1     Fields:    Translation:Humans