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Stella Kourembanas, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32HD098061 (KOUREMBANAS, STELLA) May 1, 2019 - Apr 30, 2024
    NIH/NICHD
    Neonatal Research Training Program
    Role: Principal Investigator
  2. R01HL146128 (KOUREMBANAS, STELLA) Mar 1, 2019 - Feb 28, 2023
    NIH/NHLBI
    MSC Exosome Treatment for BPD: Impact on Immunity and Lung Development
    Role: Principal Investigator
  3. R21AI134025 (KOUREMBANAS, STELLA) Jun 1, 2018 - May 31, 2020
    NIH/NIAID
    Mesenchymal Stem Cell Regulation by Syndecan-1 in Lung Injury
    Role: Principal Investigator
  4. R01HL085446 (KOUREMBANAS, STELLA) Apr 1, 2007 - Mar 31, 2013
    NIH/NHLBI
    Mesenchymal Stem Cells and Pulmonary Hypertension
    Role: Principal Investigator
  5. P50HL067669 (KOUREMBANAS, STELLA) Sep 30, 2001 - Jul 31, 2007
    NIH/NHLBI
    Injury, inflammation &repair: effect on developing lung
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hirsch K, Taglauer E, Seedorf G, Callahan C, Mandell E, White CW, Kourembanas S, Abman SH. Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental BPD. Am J Respir Crit Care Med. 2020 Jun 18. PMID: 32551816.
    Citations:    
  2. Hansmann G, Sallmon H, Roehr CC, Kourembanas S, Austin ED, Koestenberger M. Pulmonary hypertension in bronchopulmonary dysplasia. Pediatr Res. 2020 Jun 10. PMID: 32521539.
    Citations:    
  3. Spyropoulos F, Vitali SH, Touma M, Rose CD, Petty CR, Levy P, Kourembanas S, Christou H. Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020910976. PMID: 32537128.
    Citations:    
  4. Mansouri N, Willis GR, Fernandez-Gonzalez A, Reis M, Nassiri S, Mitsialis SA, Kourembanas S. Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes. JCI Insight. 2019 11 01; 4(21). PMID: 31581150.
    Citations:    
  5. Vitali SH, Fernandez-Gonzalez A, Nadkarni J, Kwong A, Rose C, Mitsialis SA, Kourembanas S. Heme oxygenase-1 dampens the macrophage sterile inflammasome response and regulates its components in the hypoxic lung. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L125-L134. PMID: 31664855.
    Citations:    
  6. Hudalla H, Michael Z, Christodoulou N, Willis GR, Fernandez-Gonzalez A, Filatava EJ, Dieffenbach P, Fredenburgh LE, Stearman RS, Geraci MW, Kourembanas S, Christou H. Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 10; 61(4):512-524. PMID: 30951642.
    Citations:    
  7. Willis GR, Fernandez-Gonzalez A, Reis M, Mitsialis SA, Kourembanas S. Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension? Int J Mol Sci. 2018 Aug 27; 19(9). PMID: 30150544.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Legchenko E, Chouvarine P, Borchert P, Fernandez-Gonzalez A, Snay E, Meier M, Maegel L, Mitsialis SA, Rog-Zielinska EA, Kourembanas S, Jonigk D, Hansmann G. PPAR? agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation. Sci Transl Med. 2018 04 25; 10(438). PMID: 29695452.
    Citations: 3     Fields:    
  9. Mitsialis SA, Willis GR, Fernandez-Gonzalez A, Kourembanas S. Reply to Muraca et al.: Exosome Treatment of Bronchopulmonary Dysplasia: How Pure Should Your Exosome Preparation Be? Am J Respir Crit Care Med. 2018 04 01; 197(7):970. PMID: 29160730.
    Citations: 1     Fields:    
  10. Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S. Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation. Am J Respir Crit Care Med. 2018 01 01; 197(1):104-116. PMID: 28853608.
    Citations: 16     Fields:    
  11. Christou H, Hudalla H, Michael Z, Filatava EJ, Li J, Zhu M, Possomato-Vieira JS, Dias-Junior C, Kourembanas S, Khalil RA. Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model. J Pharmacol Exp Ther. 2018 02; 364(2):258-274. PMID: 29212831.
    Citations:    Fields:    
  12. Willis GR, Mitsialis SA, Kourembanas S. "Good things come in small packages": application of exosome-based therapeutics in neonatal lung injury. Pediatr Res. 2018 01; 83(1-2):298-307. PMID: 28985201.
    Citations: 1     Fields:    
  13. Willis GR, Kourembanas S, Mitsialis SA. Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency. Front Cardiovasc Med. 2017; 4:63. PMID: 29062835.
    Citations: 8     
  14. Thébaud B, Kourembanas S. Can We Cure Bronchopulmonary Dysplasia? J Pediatr. 2017 12; 191:12-14. PMID: 28942897.
    Citations:    Fields:    Translation:HumansAnimalsCells
  15. Willis GR, Kourembanas S, Mitsialis SA. Therapeutic Applications of Extracellular Vesicles: Perspectives from Newborn Medicine. Methods Mol Biol. 2017; 1660:409-432. PMID: 28828676.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  16. Mitsialis SA, Kourembanas S. Stem cell-based therapies for the newborn lung and brain: Possibilities and challenges. Semin Perinatol. 2016 Apr; 40(3):138-51. PMID: 26778234.
    Citations: 14     Fields:    Translation:HumansCells
  17. Cruz FF, Borg ZD, Goodwin M, Sokocevic D, Wagner DE, Coffey A, Antunes M, Robinson KL, Mitsialis SA, Kourembanas S, Thane K, Hoffman AM, McKenna DH, Rocco PR, Weiss DJ. Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice. Stem Cells Transl Med. 2015 Nov; 4(11):1302-16. PMID: 26378259.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  18. Vitali SH, Hansmann G, Rose C, Fernandez-Gonzalez A, Scheid A, Mitsialis SA, Kourembanas S. The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up. Pulm Circ. 2014 Dec; 4(4):619-29. PMID: 25610598.
    Citations: 13     
  19. Kourembanas S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu Rev Physiol. 2015; 77:13-27. PMID: 25293529.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  20. Hale A, Lee C, Annis S, Min PK, Pande R, Creager MA, Julian CG, Moore LG, Mitsialis SA, Hwang SJ, Kourembanas S, Chan SY. An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells. Biochim Biophys Acta. 2014 Nov; 1843(11):2528-42. PMID: 24983771.
    Citations: 12     Fields:    
  21. Kourembanas S. Expanding the pool of stem cell therapy for lung growth and repair. Circulation. 2014 May 27; 129(21):2091-3. PMID: 24710032.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  22. Kourembanas S. Stem cell-based therapy for newborn lung and brain injury: feasible, safe, and the next therapeutic breakthrough? J Pediatr. 2014 May; 164(5):954-6. PMID: 24630358.
    Citations: 7     Fields:    Translation:Humans
  23. Sdrimas K, Kourembanas S. MSC microvesicles for the treatment of lung disease: a new paradigm for cell-free therapy. Antioxid Redox Signal. 2014 Nov 01; 21(13):1905-15. PMID: 24382303.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  24. Xiao Y, Christou H, Liu L, Visner G, Mitsialis SA, Kourembanas S, Liu H. Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med. 2013 Aug 15; 188(4):482-91. PMID: 23822766.
    Citations: 13     Fields:    Translation:AnimalsCells
  25. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5. PMID: 23713908.
    Citations: 13     Fields:    Translation:Humans
  26. Hamvas A, Deterding R, Balch WE, Schwartz DA, Albertine KH, Whitsett JA, Cardoso WV, Kotton DN, Kourembanas S, Hagood JS. Diffuse lung disease in children: summary of a scientific conference. Pediatr Pulmonol. 2014 Apr; 49(4):400-9. PMID: 23798474.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  27. Lee C, Mitsialis SA, Aslam M, Vitali SH, Vergadi E, Konstantinou G, Sdrimas K, Fernandez-Gonzalez A, Kourembanas S. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation. 2012 Nov 27; 126(22):2601-11. PMID: 23114789.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  28. Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr. 2012 Jul 02; 12:89. PMID: 22747567.
    Citations: 26     Fields:    Translation:Humans
  29. Hansmann G, Fernandez-Gonzalez A, Aslam M, Vitali SH, Martin T, Mitsialis SA, Kourembanas S. Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. Pulm Circ. 2012 Apr-Jun; 2(2):170-81. PMID: 22837858.
    Citations: 46     
  30. Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J. Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012 Aug; 42(8):900-13. PMID: 22435680.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  31. Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L829-37. PMID: 22328358.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  32. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L875-90. PMID: 22287610.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. Fernandez-Gonzalez A, Alex Mitsialis S, Liu X, Kourembanas S. Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 15; 302(8):L775-84. PMID: 22287607.
    Citations: 13     Fields:    Translation:HumansAnimals
  34. Vergadi E, Chang MS, Lee C, Liang OD, Liu X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S. Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension. Circulation. 2011 May 10; 123(18):1986-95. PMID: 21518986.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  35. Liang OD, Mitsialis SA, Chang MS, Vergadi E, Lee C, Aslam M, Fernandez-Gonzalez A, Liu X, Baveja R, Kourembanas S. Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. Stem Cells. 2011 Jan; 29(1):99-107. PMID: 20957739.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  36. Kourembanas S, Steinhorn R. In-house neonatology: what are we waiting for? Am J Respir Crit Care Med. 2010 Sep 15; 182(6):728-9. PMID: 20833827.
    Citations: 1     Fields:    Translation:Humans
  37. Aslam M, Baveja R, Liang OD, Fernandez-Gonzalez A, Lee C, Mitsialis SA, Kourembanas S. Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1122-30. PMID: 19713447.
    Citations: 144     Fields:    Translation:AnimalsCells
  38. Vitali SH, Mitsialis SA, Liang OD, Liu X, Fernandez-Gonzalez A, Christou H, Wu X, McGowan FX, Kourembanas S. Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One. 2009 Jun 19; 4(6):e5978. PMID: 19543386.
    Citations: 11     Fields:    Translation:AnimalsCells
  39. Fernandez-Gonzalez A, Kourembanas S, Wyatt TA, Mitsialis SA. Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):305-13. PMID: 18776131.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  40. Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22. PMID: 18391113.
    Citations: 26     Fields:    Translation:AnimalsCells
  41. Fredenburgh L, Liang O, Macias A, Polte T, Riascos D, Chung SW, Schissel S, Ingber D, Mitsialis SA, Kourembanas S, Perella M. Absence of COX-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. J Clin Invest. Submitted. 2007.
  42. Wu X, Chang, MS, Mitsialis, SA, Kourembanas, S. Hypoxia regulates bone morphogenetic protein signaling in vascular smooth muscle cells through CtBP-1. Circ. Res. 2006; 99:240-247.
  43. Wu X, Chang MS, Mitsialis SA, Kourembanas S. Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1. Circ Res. 2006 Aug 04; 99(3):240-7. PMID: 16840720.
    Citations: 16     Fields:    Translation:HumansCells
  44. Liang OD, Mitsialis SA, Kourembanas S. . Bone marrow derived mesenchymal stem cells expressing human heme oxygenase-1 (HO-1) reverse hypoxic pulmonary hypertension in HO-1 null mice. American Thoracic Society International Conference Proceedings. 2006; 3:A25.
  45. Fernandez-Gonzalez A, Naghshineh S, Mitsialis SA, Kourembanas S. Heme oxygenase-1 (HO-1) overexpression prevents fibrosis and iron deposition in developmental lung injury. American Thoracic Society International Conference Proceedings. 2006; 3:A254.
  46. Fredenburgh LE, Liang OD, Macias AA, Mitsialis SA, Kourembanas S , Perrella MA. Exacerbation of hypoxia-induced pulmonary hypertension and vascular remodeling in COX-2 deficient mice. American Thoracic Society International Conference Proceedings. 2006; 3:A278.
  47. Vitali SH, Mitsialis SA, Christou H, Fernandez-Gonzalez A, Liu X, Kourembanas S. Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin. Chest. 2005 Dec; 128(6 Suppl):578S-579S. PMID: 16373841.
    Citations: 2     Fields:    Translation:Animals
  48. Danhaive O, Margossian R, Geva T, Kourembanas S. Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates. J Perinatol. 2005 Jul; 25(7):495-9. PMID: 15830004.
    Citations: 12     Fields:    Translation:Humans
  49. Christou H, Bailey N, Kluger MS, Mitsialis SA, Kourembanas S. Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2647-52. PMID: 15681695.
    Citations: 6     Fields:    Translation:AnimalsCells
  50. Vitali S, Mitsialis SA, Christou H, Kluger M, Liu X, Kourembanas S. . HO-1 mediated cardiac protection in chronic hypoxia: Role of carbon monoxide and bilirubin. 4th International HO Conference, Boston, MA. 2005.
  51. Liang O, Mitsialis SA, Kourembanas S. . Bone-marrow derived mesenchymal stem cells expressing human HO-1 reverse hypoxic pulmonary hypertension in HO-1 null mice. 4th International HO Conference, Boston, MA. 2005.
  52. Fernandez-Gonzalez A, Naghshineh S, Mitsialis SA, Kourembanas S. . Heme Oxygenase-1 overexpression decreases alveolar remodeling and iron deposition in developmental lung injury. 4th International CO Conference, Boston, MA. 2005.
  53. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas S. Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. FASEB J. 2004 Jul; 18(10):1090-2. PMID: 15132979.
    Citations: 28     Fields:    Translation:AnimalsCells
  54. Kourembanas S. Shock. Manual of Neonatal Care(Cloherty JP, Eichenwald E, Stark AR, eds.). 2004; 181-185.
  55. Vitali S, Mitsialis SA, Christou H, Kourembanas S . Mechanisms of HO-1 cytoprotection in hypoxic pulmonary hypertension. Pediatric Research. 2004; 55(4):A2683.
  56. Wu X, Kourembanas S . Hypoxia suppresses bone morphogenetic protein mediated Id1 gene activation n human pulmonary artery smooth muscle cells. Am. J. Respir. Crit. Care Med. 2004; A510.
  57. Zampetaki A, Minamino T, Mitsialis SA, Kourembanas S. Effect of heme oxygenase-1 overexpression in two models of lung inflammation. Exp Biol Med (Maywood). 2003 May; 228(5):442-6. PMID: 12709566.
    Citations: 18     Fields:    Translation:HumansAnimals
  58. Christou H, Mitsialis SA, Kourembanas S. Regulation of heme oxygenase-1 (HO-1) gene expression in vascular smooth muscle cells by extracellular acidosis. Pediatric Research. 2003; 53(4):A3220.
  59. Kourembanas S. Hypoxia and carbon monoxide in the vasculature. Antioxid Redox Signal. 2002 Apr; 4(2):291-9. PMID: 12006180.
    Citations: 12     Fields:    Translation:HumansAnimals
  60. Zampetaki A, Mitsialis SA, Pfeilschifter J, Kourembanas, S. Regulation of macrophage inflammatory protein-2 (MIP-2) gene expression by hypoxia. Am. J. Respir. Crit. Care Med. 2002; 165(8):A546.
  61. Brodsky D, Christou H, Bernfield M, Kourembanas S. Response of the developing lung to injury (Haddad GG, Abman S, Chernik V, eds.). Basic Mechanisms of Pediatric Respiratory Disease. 2002; 102-123.
  62. Kourembanas S, Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Atwater L, Abraham NG, Perrella MA, Mitsialis SA. Targeted expression of heme oxygenase-1 and pulmonary responses to hypoxia. Heme Oxygenase in Biology and Medicine. 2002; 193-204.
  63. Minamino T, Kourembanas S. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res. 2001 Aug 03; 89(3):237-43. PMID: 11485973.
    Citations: 19     Fields:    Translation:AnimalsCells
  64. Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803. PMID: 11447290.
    Citations: 101     Fields:    Translation:HumansAnimals
  65. Ellington M, O'Reilly D, Allred EN, McCormick MC, Wessel DL, Kourembanas S. Child health status, neurodevelopmental outcome, and parental satisfaction in a randomized, controlled trial of nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics. 2001 Jun; 107(6):1351-6. PMID: 11389256.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  66. Minamino T, Mitsialis SA, Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol. 2001 May; 21(10):3336-42. PMID: 11313459.
    Citations: 39     Fields:    Translation:AnimalsCells
  67. Christou H, Van Marter LJ, Wessel DL, Allred EN, Kane JW, Thompson JE, Stark AR, Kourembanas S. Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn. Crit Care Med. 2000 Nov; 28(11):3722-7. PMID: 11098980.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  68. Christou H, Morita T, Hsieh CM, Koike H, Arkonac B, Perrella MA, Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res. 2000 Jun 23; 86(12):1224-9. PMID: 10864912.
    Citations: 53     Fields:    Translation:Animals
  69. Yet S-F, Perrella MA, Christou H, Tian R, Ingwall J, Kourembanas S, Lee M-E. The role of heme oxygenase-1 in the regulation of cardiomyocyte death during ischemia/reperfusion. Acta Haematologica. 2000; 103(1):A276.
  70. Brodsky S, Mitsialis SA, Minamino T, Kourembanas S. Herbimycin A and geldanamycin inhibit the hypoxic induction of the vascular endothelial growth factor (VEGF) gene in pulmonary artery endothelial cells. Pediatric Research. 2000; 47(4):A380.
  71. Kourembanas S, Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Lynch L, Abraham NG, Perrella MA, Mitsialis SA. Heme oxygenase and pulmonary responses to hypoxia. Acta Haematologica. 2000; 103(1):A247.
  72. Christou H, Minamino T, Hsieh C-M, Liu Y, Lynch L, Mitsialis SA, Perrella MA, Kourembanas S. Transgenic mice overexpressing heme oxygenase-1 (HO-1) in the lung are protected from development of hypoxia-induced pulmonary hypertension: Evidence of antiinflammatory effects of HO-1. Pediatric Research. 2000; 47(4):A385.
  73. Christou H, Minamino T, Mitsialis SA, Kourembanas S. Extracellular acidosis induces heme oxygenase-1 (HO-1) gene expression in vascular smooth muscle cells. Pediatric Research. 2000; 47(4):A386.
  74. Maemura K, Hsieh CM, Jain MK, Fukumoto S, Layne MD, Liu Y, Kourembanas S, Yet SF, Perrella MA, Lee ME. Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. J Biol Chem. 1999 Oct 29; 274(44):31565-70. PMID: 10531360.
    Citations: 16     Fields:    Translation:AnimalsCells
  75. Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9. PMID: 10207174.
    Citations: 102     Fields:    Translation:Animals
  76. Maemura K, Mukesh JK, Hsieh C-M, Fukumoto S, Kourembanas S, Yet S-F, Perrella MA, Lee M-E. Functional analysis of endothelial PAS domain Protein 1: Generation of a dominant negative mutant by deleting C-terminal potent transactivation domain. Circulation. 1999; 100(18):A193.
  77. Christou H, Magnani B, Morse DS, Allred EN, Van Marter LJ, Wessel DL, Kourembanas S. Inhaled nitric oxide does not affect adenosine 5'-diphosphate-dependent platelet activation in infants with persistent pulmonary hypertension of the newborn. Pediatrics. 1998 Dec; 102(6):1390-3. PMID: 9832574.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  78. Kourembanas S, Morita T, Christou H, Liu Y, Koike H, Brodsky D, Arthur V, Mitsial SA. Hypoxic responses of vascular cells. Chest. 1998 Jul; 114(1 Suppl):25S-28S. PMID: 9676610.
    Citations: 7     Fields:    Translation:HumansAnimals
  79. Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. J Biol Chem. 1998 Jun 12; 273(24):15257-62. PMID: 9614141.
    Citations: 25     Fields:    Translation:AnimalsCells
  80. Christou H, Yoshida A, Arthur V, Morita T, Kourembanas S. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 1998 Jun; 18(6):768-76. PMID: 9618381.
    Citations: 31     Fields:    Translation:Animals
  81. Maemura K, Jain MK, Decarie LA, Liu Y, Kourembanas S, Milstone DS, Lee S-L, Perrella MA, Yet S-F, Lee M-E. Activation of KDR/flk-1 promoter by endothelial PAS domain protein-1: Potential role of endothelial PAS domain protein-1 in endothelial cell differentiation. Circulation. 1998.
  82. Christou H, Van Marter LJ, Wessel DL, Allred EN, Kane JW, Thompson JE, Stark AR, Kourembanas S. Combination of inhaled nitric oxide with high frequency ventilation reduces the need for extracorporeal membrane oxygenation in infants with persistant pulmonary hypertension of the newborn: Results from a single center trial. Pediatric Research. 1998; 43(4):169A.
  83. Maemura K, Fukumoto S, Jain MK, Kourembanas S, Perrella MA, Yet S-F, Lee M-E. Characterization of functional domains of endothelial PAS domain protein-1 and generation of a dominant negative mutant. Circulation. 1998.
  84. Kourembanas S. Shock. Manual of Neonatal Care (Cloherty JP and Stark AR, eds.). 1998; 171-173.
  85. Morita T, Mitsialis SA, Koike H, Liu Y, Kourembanas S. Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells. J Biol Chem. 1997 Dec 26; 272(52):32804-9. PMID: 9407056.
    Citations: 56     Fields:    Translation:AnimalsCells
  86. Wessel DL, Adatia I, Van Marter LJ, Thompson JE, Kane JW, Stark AR, Kourembanas S. Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics. 1997 Nov; 100(5):E7. PMID: 9347001.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  87. Hammerman SI, Kourembanas S, Conca TJ, Tucci M, Brauer M, Farber HW. Endothelin-1 production during the acute chest syndrome in sickle cell disease. Am J Respir Crit Care Med. 1997 Jul; 156(1):280-5. PMID: 9230761.
    Citations: 20     Fields:    Translation:HumansAnimals
  88. Christou H, Adatia I, Van Marter LJ, Kane JW, Thompson JE, Stark AR, Wessel DL, Kourembanas S. Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J Pediatr. 1997 Apr; 130(4):603-11. PMID: 9108859.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  89. Kourembanas S, Morita T, Liu Y, Christou H. Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Kidney Int. 1997 Feb; 51(2):438-43. PMID: 9027718.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  90. Christou H, Morita T, Koike H, Hsieh, CM, Perrella M, Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Pediatric Research. 1997; 41:A238.
  91. Christou H, Magnani B, Morse D, Allred E, Van Marter L, Wessel D, Kourembanas S. Inhaled nitric oxide does not inhibit platelet activation in infants with persistent pulmonary hypertension of the newborn (PPHN). Pediatric Research. 1997; 41:A844.
  92. Morita T, Kourembanas S, Togashi A, Negishi K, Katayama S. Endogenous carbon monoxide regulates tube formation by human microvascular endothelial cells under high glucose. Circulation. 1997; 96(8):A4067.
  93. Kourembanas S. Regulation of Carbon Monoxide Producation and Vascular Responses. Ketsuatsu - Japanese Journal of Blood Pressure. 1996; 3(2):260-268.
  94. Wessel D, Adatia I, Thompson J, Kane J, Van Marter L, Stark A, Kourembanas S. Improved oxygenation in a randomized trial of inhaled nitric oxide for PPHN. Pediatric Research. 1996; 39(4):A1498.
  95. Morita T, Kourembanas S. Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest. 1995 Dec; 96(6):2676-82. PMID: 8675634.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  96. Kostyk SK, Kourembanas S, Wheeler EL, Medeiros D, McQuillan LP, D'Amore PA, Braunhut SJ. Basic fibroblast growth factor increases nitric oxide synthase production in bovine endothelial cells. Am J Physiol. 1995 Nov; 269(5 Pt 2):H1583-9. PMID: 7503252.
    Citations: 11     Fields:    Translation:AnimalsCells
  97. Liu Y, Cox SR, Morita T, Kourembanas S. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res. 1995 Sep; 77(3):638-43. PMID: 7641334.
    Citations: 190     Fields:    Translation:AnimalsCells
  98. Morita T, Perrella MA, Lee ME, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1475-9. PMID: 7878003.
    Citations: 98     Fields:    Translation:AnimalsCells
  99. Itoh A, Levinson SF, Morita T, Kourembanas S, Brody JS, Mitsialis SA. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Cell Mol Biol Res. 1995; 41(3):147-54. PMID: 8589754.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  100. Kourembanas S. Persistent pulmonary hypertension of the newborn: Role of nitric oxide. J. Int. Care Medicine. 1995; 10:270-282.
  101. Liu Y, Cox S, Kourembanas S. Hypoxia upregulates the transcription of human vascular endothelial growth factor gene via a 28-bp enhancer. FASEB J. 1995; 9(3):A611.
  102. Kourembanas S, Stark AR. Inhaled NO for PPHN: Basic Biology to Clinical Application (Fanaroff AA and Klaus MH, eds.). 1995 Year Book of Neonatal and Perinatal Medicine. 1995; xvii-xxxvi.
  103. Morita T, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of endothelial cell gene expression and cGMP content. Circulation. 1995; 92(8):110.
  104. Christou H, Yoshida H, Morita T, Kourembanas S. Increased epithelial cell expression of vascular endothelial growth factor (VEGF) in the lungs of animals with hypoxia-induced pulmonary hypertension. Am. J. Resp. Crit. Care Med. 1995; 151(4):A732.
  105. Morita T, Perrella MA, Lee M-E, Kourembanas S. Hypoxia increases cGMP levels in rat vascular smooth muscle cells via inducation of heme oxygenase-1. 67th Scientific Sessions of the American Heart Assocation, Dallas, TX. 1994.
  106. McQuillan LP, Leung GK, Marsden PA, Kostyk SK, Kourembanas S. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am J Physiol. 1994 Nov; 267(5 Pt 2):H1921-7. PMID: 7526714.
    Citations: 70     Fields:    Translation:HumansCells
  107. Kourembanas S, Bernfield M. Hypoxia and endothelial-smooth muscle cell interactions in the lung. Am J Respir Cell Mol Biol. 1994 Oct; 11(4):373-4. PMID: 7917305.
    Citations: 3     Fields:    Translation:HumansAnimals
  108. Perrella MA, Yoshizumi M, Fen Z, Tsai JC, Hsieh CM, Kourembanas S, Lee ME. Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells. J Biol Chem. 1994 May 20; 269(20):14595-600. PMID: 7514175.
    Citations: 23     Fields:    Translation:AnimalsCells
  109. Kourembanas S, McQuillan L, Christou H, Adatia I, Van Marter L, Kane J, Thompson J, Fackler J, Wessel D, Stark A. Inhaled nitric oxide (NO) alters endogenous endothelin-1 (ET-1) and cGMP levels in newborns with persistent pulmonary hypertension (PPHN). Pediatric Research. 1994; 35(4):234A.
  110. Kourembanas S, McQuillan LP, Leung GK, Faller DV. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest. 1993 Jul; 92(1):99-104. PMID: 8326022.
    Citations: 74     Fields:    Translation:HumansCells
  111. Kourembanas S, Leung GK, McQuillan LP. Hypoxia inhibits nitric oxide synthase (NOS) gene expression and nitric oxide (NO) production in endothelial cells. Pediatric Research. 1993; 33:51A.
  112. Yoshizumi M, Kourembanas S, Temizer DH, Cambria RP, Quertermous T, Lee ME. Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells. J Biol Chem. 1992 May 15; 267(14):9467-9. PMID: 1577791.
    Citations: 23     Fields:    Translation:HumansCells
  113. Kourembanas S. Hypoxic responses of the neonatal endothelium. Semin Perinatol. 1992 Apr; 16(2):140-6. PMID: 1636128.
    Citations:    Fields:    Translation:Humans
  114. Kourembanas S, Marsden P, Faller DV. Feedback loops regulated the production of vasoactive agents by human endothelial cells. Pediatric Research. 1992; 31:46A.
  115. Kourembanas S, Marsden PA, McQuillan LP, Faller DV. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest. 1991 Sep; 88(3):1054-7. PMID: 1885767.
    Citations: 100     Fields:    Translation:HumansCells
  116. Kourembanas S, Marsden P, McQuillan LP, Faller DV. Molecular mechanisms contrbuting to hypoxic vasoconstriction. Pediatric Research. 1991; 29:255A.
  117. Kourembanas S. Shock. Manual of Neonatal Care (Cloherty JP and Stark AR, eds.). 1991; 68-71.
  118. Kourembanas S, Hannan RL, Faller DV. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J Clin Invest. 1990 Aug; 86(2):670-4. PMID: 2384608.
    Citations: 63     Fields:    Translation:HumansCells
  119. Torday JS, Kourembanas S. Fetal rat lung fibroblasts produce a TGF beta homolog that blocks alveolar type II cell maturation. Dev Biol. 1990 May; 139(1):35-41. PMID: 2328838.
    Citations: 8     Fields:    Translation:AnimalsCells
  120. Kourembanas S, Marsden P, Faller DV. Molecular mechanisms contributing to vaso-occlusion in sickle cell disease. Blood. 1990; 76:10S1.
  121. Kourembanas S, Faller DV. Platelet-derived growth factor production by human umbilical vein endothelial cells is regulated by basic fibroblast growth factor. J Biol Chem. 1989 Mar 15; 264(8):4456-9. PMID: 2925652.
    Citations: 10     Fields:    Translation:HumansCells
  122. Kourembanas S, Hannan RL, Faller DV. Hypoxia stimulates platelet-derived growth factor (PDGF) production by human umbilical vein endothelial cells (HUVEC). Pediatric Research. 1989; 25:54A.
  123. Faller DV, Kourembanas S, Ginsberg D, Hannan R, Collins T, Ewenstein BM, Pober JS, Tantravahi R. Immortalization of human endothelial cells by murine sarcoma viruses, without morphologic transformation. J Cell Physiol. 1988 Jan; 134(1):47-56. PMID: 2826502.
    Citations: 7     Fields:    Translation:HumansCells
  124. Kourembanas S, Faller DV. Regulation of platelet-derived growth factor (PDGF) gene expression by basic fibroblast growth factor (bFGF) in human umbilical vein endothelial cells. Pediatric Research. 1988; 23:245A.
  125. Hannan RL, Kourembanas S, Flanders KC, Rogelj SJ, Roberts AB, Faller DV, Klagsbrun M. Endothelial cells synthesize basic fibroblast growth factor and transforming growth factor beta. Growth Factors. 1988; 1(1):7-17. PMID: 3272801.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  126. Phelps DS, Church S, Kourembanas S, Taeusch HW, Floros J . Increases in the 35kDa surfactant-associated protein and its mRNA following in vivo dexamethasone treatment of fetal and neonatal rats. Electrophoresis. 1987; 8:235-238.
  127. Floros J, Phelps DS, Kourembanas S, Taeusch HW. Primary translation products, biosynthesis, and tissue specificity of the major surfactant protein in rat. J Biol Chem. 1986 Jan 15; 261(2):828-31. PMID: 3753602.
    Citations: 4     Fields:    Translation:AnimalsCells
  128. Kourembanas S, Floros J, Phelps DS, Taeusch HW. Developmental profile of surgactant associated protein (Apoprotein A) in the rat lung. Eleventh Annual New England Conference on Perinatal Resesarch. 1985.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.