Harvard Catalyst Profiles

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Mark Daniel Fleming, M.D., D.Phil.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL125710 (FINLEY, DANIEL J) May 15, 2015 - Mar 31, 2019
    NIH/NHLBI
    A novel program of ubiquitination in global remodeling of the erythroid proteome
    Role: Co-Principal Investigator
  2. R24DK099808 (SHIMAMURA, AKIKO) Sep 29, 2013 - Aug 31, 2018
    NIH/NIDDK
    Translational Studies of Inherited Marrow Failure and Myelodysplastic Syndromes
    Role: Co-Principal Investigator
  3. R01DK100806 (FLEMING, MARK D) Sep 18, 2013 - Jun 30, 2017
    NIH/NIDDK
    Murine Models of Heme Metabolism and Iron Recycling
    Role: Principal Investigator
  4. R24DK094746 (WILLIAMS, DAVID A) Aug 1, 2012 - Jul 31, 2014
    NIH/NIDDK
    Molecular Genetic Investigation of Pediatric Myelodysplastic Syndrome
    Role: Co-Principal Investigator
  5. R21HL116210 (FINLEY, DANIEL J) May 15, 2012 - Apr 30, 2014
    NIH/NHLBI
    Ubiquitination in erythropoiesis and the pathophysiology of anemia
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guerra A, Oikonomidou PR, Sinha S, Zhang J, Lo Presti V, Hamilton CR, Breda L, Casu C, La P, Martins AC, Sendamarai AK, Fleming M, Rivella S. Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of beta-thalassemia. Blood. 2019 May 31. PMID: 31151988.
    Citations:    
  2. Rowe RG, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, Yermalovich A, Barragan J, Mathieu R, Jha DK, Fleming MD, North TE, Daley GQ. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019 Mar 04; 216(3):527-538. PMID: 30728174.
    Citations:    
  3. Yin S, Gambe RG, Sun J, Martinez AZ, Cartun ZJ, Regis FFD, Wan Y, Fan J, Brooks AN, Herman SEM, Ten Hacken E, Taylor-Weiner A, Rassenti LZ, Ghia EM, Kipps TJ, Obeng EA, Cibulskis CL, Neuberg D, Campagna DR, Fleming MD, Ebert BL, Wiestner A, Leshchiner I, DeCaprio JA, Getz G, Reed R, Carrasco RD, Wu CJ, Wang L. A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. Cancer Cell. 2019 Feb 11; 35(2):283-296.e5. PMID: 30712845.
    Citations:    
  4. Lopez R, DeMartino R, Fleming M, Bjarnason H, Neisen M. Aspiration thrombectomy for acute iliofemoral or central deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2019 Mar; 7(2):162-168. PMID: 30639411.
    Citations:    Fields:    
  5. Santana-Codina N, Gableske S, Rey MQD, Malachowska B, Jedrychowski MP, Biancur DE, Schmidt PJ, Fleming MD, Fendler W, Harper JW, Kimmelman AC, Mancias JD. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica. 2019 Jul; 104(7):1342-1354. PMID: 30630985.
    Citations:    Fields:    
  6. Chisholm KM, Denton C, Keel S, Geddis AE, Xu M, Appel BE, Cantor AB, Fleming MD, Shimamura A. Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy. Pediatr Dev Pathol. 2019 Jul-Aug; 22(4):315-328. PMID: 30600763.
    Citations:    Fields:    
  7. Ducamp S, Fleming MD. The molecular genetics of sideroblastic anemia. Blood. 2019 Jan 03; 133(1):59-69. PMID: 30401706.
    Citations:    Fields:    
  8. Fleming MD, Shim JK, Yen I, Van Natta M, Hanssmann C, Burke NJ. Caring for "Super-utilizers": Neoliberal Social Assistance in the Safety-net. Med Anthropol Q. 2019 Jun; 33(2):173-190. PMID: 30291726.
    Citations:    Fields:    
  9. Van Natta M, Burke NJ, Yen IH, Fleming MD, Hanssmann CL, Rasidjan MP, Shim JK. Stratified citizenship, stratified health: Examining latinx legal status in the U.S. healthcare safety net. Soc Sci Med. 2019 Jan; 220:49-55. PMID: 30391641.
    Citations:    Fields:    
  10. Gansner JM, Furutani E, Campagna DR, Fleming MD, Shimamura A. Pancreatic lipomatosis in Diamond-Blackfan anemia: The importance of genetic testing in bone marrow failure disorders. Am J Hematol. 2018 09; 93(9):1194-1195. PMID: 29885000.
    Citations:    Fields:    
  11. Riley LG, Heeney MM, Rudinger-Thirion J, Frugier M, Campagna DR, Zhou R, Hale GA, Hilliard LM, Kaplan JA, Kwiatkowski JL, Sieff CA, Steensma DP, Rennings AJ, Simons A, Schaap N, Roodenburg RJ, Kleefstra T, Arenillas L, Fita-Torró J, Ahmed R, Abboud M, Bechara E, Farah R, Tamminga RYJ, Bottomley SS, Sanchez M, Huls G, Swinkels DW, Christodoulou J, Fleming MD. The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2. Haematologica. 2018 Dec; 103(12):2008-2015. PMID: 30026338.
    Citations:    
  12. Berhe S, Heeney MM, Campagna DR, Thompson JF, White EJ, Ross T, Peake RWA, Hanrahan JD, Rodriguez V, Renaud DL, Patnaik MS, Chang E, Bottomley SS, Fleming MD. Recurrent heteroplasmy for the MT-ATP6 p.Ser148Asn (m.8969G>A) mutation in patients with syndromic congenital sideroblastic anemia of variable clinical severity. Haematologica. 2018 Dec; 103(12):e561-e563. PMID: 30006447.
    Citations:    
  13. Hickson LJ, Rule AD, Thorsteinsdottir B, Shields RC, Porter IE, Fleming MD, Ubl DS, Crowson CS, Hanson KT, Elhassan BT, Mehrotra R, Arya S, Albright RC, Williams AW, Habermann EB. Predictors of early mortality and readmissions among dialysis patients undergoing lower extremity amputation. J Vasc Surg. 2018 11; 68(5):1505-1516. PMID: 30369411.
    Citations:    Fields:    
  14. Hofmann I, Geer MJ, Vögtle T, Crispin A, Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijpers MJE, Heemskerk JWM, Eble JA, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Jarvis GE, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA. Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. Blood. 2018 09 27; 132(13):1399-1412. PMID: 29898956.
    Citations: 1     Fields:    
  15. Heeney MM, Guo D, De Falco L, Campagna DR, Olbina G, Kao PP, Schmitz-Abe K, Rahimov F, Gutschow P, Westerman K, Ostland V, Jackson T, Klaassen RJ, Markianos K, Finberg KE, Iolascon A, Westerman M, London WB, Fleming MD. Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency. Blood. 2018 07 26; 132(4):448-452. PMID: 29895660.
    Citations:    Fields:    
  16. Dombrowski JC, Hughes JP, Buskin SE, Bennett A, Katz D, Fleming M, Nunez A, Golden MR. A Cluster Randomized Evaluation of a Health Department Data to Care Intervention Designed to Increase Engagement in HIV Care and Antiretroviral Use. Sex Transm Dis. 2018 06; 45(6):361-367. PMID: 29465679.
    Citations: 2     Fields:    
  17. Mirza AK, Stauffer K, Fleming MD, De Martino R, Oderich G, Kalra M, Gloviczki P, Bower T. Endoscopic versus open great saphenous vein harvesting for femoral to popliteal artery bypass. J Vasc Surg. 2018 04; 67(4):1199-1206. PMID: 29102747.
    Citations:    Fields:    Translation:Humans
  18. Schmidt PJ, Liu K, Visner G, Fitzgerald K, Fishman S, Racie T, Hettinger JL, Butler JS, Fleming MD. RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of ß-thalassemia intermedia. Am J Hematol. 2018 Jun; 93(6):745-750. PMID: 29498084.
    Citations:    Fields:    
  19. Van Natta M, Burke NJ, Yen IH, Rubin S, Fleming MD, Thompson-Lastad A, Shim JK. Complex care and contradictions of choice in the safety net. Sociol Health Illn. 2018 03; 40(3):538-551. PMID: 29424102.
    Citations:    Fields:    Translation:Humans
  20. Carapito R, Konantz M, Paillard C, Miao Z, Pichot A, Leduc MS, Yang Y, Bergstrom KL, Mahoney DH, Shardy DL, Alsaleh G, Naegely L, Kolmer A, Paul N, Hanauer A, Rolli V, Müller JS, Alghisi E, Sauteur L, Macquin C, Morlon A, Sancho CS, Amati-Bonneau P, Procaccio V, Mosca-Boidron AL, Marle N, Osmani N, Lefebvre O, Goetz JG, Unal S, Akarsu NA, Radosavljevic M, Chenard MP, Rialland F, Grain A, Béné MC, Eveillard M, Vincent M, Guy J, Faivre L, Thauvin-Robinet C, Thevenon J, Myers K, Fleming MD, Shimamura A, Bottollier-Lemallaz E, Westhof E, Lengerke C, Isidor B, Bahram S. Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. J Clin Invest. 2017 Nov 01; 127(11):4090-4103. PMID: 28972538.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  21. Donohoe S, Alluri RK, Hill JR, Fleming M, Tan E, Marecek G. Impact of Computed Tomography on Operative Planning for Ankle Fractures Involving the Posterior Malleolus. Foot Ankle Int. 2017 Dec; 38(12):1337-1342. PMID: 28954524.
    Citations:    Fields:    Translation:Humans
  22. Thompson-Lastad A, Yen IH, Fleming MD, Van Natta M, Rubin S, Shim JK, Burke NJ. Response to commentary, "Trauma and the structuring of complex care: Back to the settlements?" by Elizabeth Bowen. Soc Sci Med. 2017 11; 192:28-29. PMID: 28957781.
    Citations:    Fields:    
  23. Garcia LA, Rocha-Singh KJ, Krishnan P, Zeller T, Tepe G, Fleming M, Granada JF, Turco MA, Tieché C, Jaff MR. Angiographic classification of patterns of restenosis following femoropopliteal artery intervention: A proposed scoring system. Catheter Cardiovasc Interv. 2017 Oct 01; 90(4):639-646. PMID: 28795488.
    Citations:    Fields:    Translation:Humans
  24. Nguyen AT, Prado MA, Schmidt PJ, Sendamarai AK, Wilson-Grady JT, Min M, Campagna DR, Tian G, Shi Y, Dederer V, Kawan M, Kuehnle N, Paulo JA, Yao Y, Weiss MJ, Justice MJ, Gygi SP, Fleming MD, Finley D. UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017 08 04; 357(6350). PMID: 28774900.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Thompson-Lastad A, Yen IH, Fleming MD, Van Natta M, Rubin S, Shim JK, Burke NJ. Defining trauma in complex care management: Safety-net providers' perspectives on structural vulnerability and time. Soc Sci Med. 2017 08; 186:104-112. PMID: 28618290.
    Citations:    Fields:    Translation:Humans
  26. Huang Y, Gloviczki P, Duncan AA, Fleming MD, Driscoll DJ, Kalra M, Oderich GS, Bower TC. Management of refractory chylous ascites with peritoneovenous shunts. J Vasc Surg Venous Lymphat Disord. 2017 07; 5(4):538-546. PMID: 28623993.
    Citations:    Fields:    Translation:Humans
  27. Fleming MD, Shim JK, Yen IH, Thompson-Lastad A, Rubin S, Van Natta M, Burke NJ. Patient engagement at the margins: Health care providers' assessments of engagement and the structural determinants of health in the safety-net. Soc Sci Med. 2017 06; 183:11-18. PMID: 28445806.
    Citations: 1     Fields:    Translation:Humans
  28. Sun PY, Fleming MD, Stauffer K, Kalra M, Oderich G, Bower T, Gloviczki P, DeMartino RR. Outcome of peripheral venous reconstructions during tumor resection. J Vasc Surg Venous Lymphat Disord. 2017 03; 5(2):185-193. PMID: 28214485.
    Citations:    Fields:    Translation:Humans
  29. Huang Y, Gloviczki P, Duncan AA, Kalra M, Oderich GS, Fleming MD, Harmsen WS, Bower TC. Maximal aortic diameter affects outcome after endovascular repair of abdominal aortic aneurysms. J Vasc Surg. 2017 05; 65(5):1313-1322.e4. PMID: 28034585.
    Citations:    Fields:    Translation:Humans
  30. Cattivelli K, Campagna DR, Schmitz-Abe K, Heeney MM, Yaish HM, Caruso Brown AE, Kearney S, Walkovich K, Markianos K, Fleming MD, Neufeld EJ. Ringed sideroblasts in ß-thalassemia. Pediatr Blood Cancer. 2017 05; 64(5). PMID: 27808451.
    Citations:    Fields:    Translation:HumansCells
  31. Obeng EA, Chappell RJ, Seiler M, Chen MC, Campagna DR, Schmidt PJ, Schneider RK, Lord AM, Wang L, Gambe RG, McConkey ME, Ali AM, Raza A, Yu L, Buonamici S, Smith PG, Mullally A, Wu CJ, Fleming MD, Ebert BL. Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation. Cancer Cell. 2016 09 12; 30(3):404-417. PMID: 27622333.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  32. Boyraz B, Bellomo CM, Fleming MD, Cutler CS, Agarwal S. A novel TERC CR4/CR5 domain mutation causes telomere disease via decreased TERT binding. Blood. 2016 10 20; 128(16):2089-2092. PMID: 27587879.
    Citations:    Fields:    Translation:HumansCells
  33. Lichtenstein DA, Crispin AW, Sendamarai AK, Campagna DR, Schmitz-Abe K, Sousa CM, Kafina MD, Schmidt PJ, Niemeyer CM, Porter J, May A, Patnaik MM, Heeney MM, Kimmelman A, Bottomley SS, Paw BH, Markianos K, Fleming MD. A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. Blood. 2016 10 13; 128(15):1913-1917. PMID: 27488349.
    Citations: 3     Fields:    Translation:HumansCells
  34. Heideman PP, Rajebi MR, McKusick MA, Bjarnason H, Oderich GS, Friese JL, Fleming MD, Stockland AH, Harmsen WS, Mandrekar J, Misra S. Impact of Chronic Kidney Disease on Clinical Outcomes of Endovascular Treatment for Femoropopliteal Arterial Disease. J Vasc Interv Radiol. 2016 Aug; 27(8):1204-14. PMID: 27321888.
    Citations:    Fields:    Translation:Humans
  35. Gifford SM, Fleming MD, Mendes BC, Stauffer KC, De Martino RR, Oderich GS, Gloviczki P, Bower TC. Impact of femoropopliteal endovascular interventions on subsequent open bypass. J Vasc Surg. 2016 09; 64(3):623-8. PMID: 27288105.
    Citations: 1     Fields:    Translation:Humans
  36. Cao C, Fleming MD. The placenta: the forgotten essential organ of iron transport. Nutr Rev. 2016 07; 74(7):421-31. PMID: 27261274.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Mangum JE, Hardee JP, Fix DK, Puppa MJ, Elkes J, Altomare D, Bykhovskaya Y, Campagna DR, Schmidt PJ, Sendamarai AK, Lidov HG, Barlow SC, Fischel-Ghodsian N, Fleming MD, Carson JA, Patton JR. Pseudouridine synthase 1 deficient mice, a model for Mitochondrial Myopathy with Sideroblastic Anemia, exhibit muscle morphology and physiology alterations. Sci Rep. 2016 05 20; 6:26202. PMID: 27197761.
    Citations: 4     Fields:    Translation:Animals
  38. Peeran S, DeMartino RR, Huang Y, Fleming M, Kalra M, Oderich GS, Duncan AA, Bower TC, Gloviczki P. Outcomes of Women Treated for Popliteal Artery Aneurysms. Ann Vasc Surg. 2016 Jul; 34:187-92. PMID: 27116904.
    Citations:    Fields:    Translation:Humans
  39. Guo W, Schmidt PJ, Fleming MD, Bhasin S. Effects of Testosterone on Erythropoiesis in a Female Mouse Model of Anemia of Inflammation. Endocrinology. 2016 07; 157(7):2937-46. PMID: 27074351.
    Citations: 3     Fields:    Translation:Animals
  40. Gifford SM, Duncan AA, Greiten LE, Gloviczki P, Oderich GS, Kalra M, Fleming MD, Bower TC. The natural history and outcomes for thoracic and abdominal penetrating aortic ulcers. J Vasc Surg. 2016 05; 63(5):1182-8. PMID: 26852004.
    Citations: 1     Fields:    Translation:Humans
  41. Jabara HH, Boyden SE, Chou J, Ramesh N, Massaad MJ, Benson H, Bainter W, Fraulino D, Rahimov F, Sieff C, Liu ZJ, Alshemmari SH, Al-Ramadi BK, Al-Dhekri H, Arnaout R, Abu-Shukair M, Vatsayan A, Silver E, Ahuja S, Davies EG, Sola-Visner M, Ohsumi TK, Andrews NC, Notarangelo LD, Fleming MD, Al-Herz W, Kunkel LM, Geha RS. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016 Jan; 48(1):74-8. PMID: 26642240.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  42. Latour C, Besson-Fournier C, Meynard D, Silvestri L, Gourbeyre O, Aguilar-Martinez P, Schmidt PJ, Fleming MD, Roth MP, Coppin H. Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin. Hepatology. 2016 Jan; 63(1):126-37. PMID: 26406355.
    Citations: 12     Fields:    Translation:Animals
  43. Fleming MD, Pockaj BA, Hansen AJ, Gray RJ, Patel MD. Radioactive seed localization for excision of non-palpable in-transit metastatic melanoma. Radiol Case Rep. 2006; 1(2):54-7. PMID: 27298682.
    Citations:    
  44. Riley LG, Rudinger-Thirion J, Schmitz-Abe K, Thorburn DR, Davis RL, Teo J, Arbuckle S, Cooper ST, Campagna DR, Frugier M, Markianos K, Sue CM, Fleming MD, Christodoulou J. LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. JIMD Rep. 2016; 28:49-57. PMID: 26537577.
    Citations: 5     
  45. Schmitz-Abe K, Ciesielski SJ, Schmidt PJ, Campagna DR, Rahimov F, Schilke BA, Cuijpers M, Rieneck K, Lausen B, Linenberger ML, Sendamarai AK, Guo C, Hofmann I, Newburger PE, Matthews D, Shimamura A, Snijders PJ, Towne MC, Niemeyer CM, Watson HG, Dziegiel MH, Heeney MM, May A, Bottomley SS, Swinkels DW, Markianos K, Craig EA, Fleming MD. Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9. Blood. 2015 Dec 17; 126(25):2734-8. PMID: 26491070.
    Citations: 8     Fields:    Translation:HumansCells
  46. Strajina V, Oderich GS, Fatima J, Gloviczki P, Duncan AA, Kalra M, Fleming M, Macedo TA. Endovascular aortic aneurysm repair in patients with narrow aortas using bifurcated stent grafts is safe and effective. J Vasc Surg. 2015 Nov; 62(5):1140-7.e1. PMID: 26372194.
    Citations:    Fields:    Translation:Humans
  47. Reed NR, Oderich GS, Manunga J, Duncan A, Misra S, de Souza LR, Fleming M, de Martino R. Feasibility of endovascular repair of splenic artery aneurysms using stent grafts. J Vasc Surg. 2015 Dec; 62(6):1504-10. PMID: 26365664.
    Citations: 1     Fields:    Translation:Humans
  48. Herrmann J, Bell MR, Warren RL, Lerman A, Fleming MD, Patnaik M. Complicated and Advanced Atherosclerosis in a Young Woman With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Success and Challenges of BCR/ABL1-Targeted Cancer Therapy. Mayo Clin Proc. 2015 Aug; 90(8):1167-8. PMID: 26250733.
    Citations: 3     Fields:    Translation:Humans
  49. Cao C, Fleming MD. The ins and outs of erythroid heme transport. Haematologica. 2015 Jun; 100(6):703. PMID: 26034110.
    Citations:    Fields:    Translation:HumansAnimalsCells
  50. Johnstone JK, Fleming MD, Gloviczki P, Stone W, Kalra M, Oderich GS, Duncan AA, De Martino RR, Bower TC. Surgical treatment of popliteal venous aneurysms. Ann Vasc Surg. 2015 Aug; 29(6):1084-9. PMID: 26009475.
    Citations:    Fields:    Translation:Humans
  51. Scott A, Glover J, Skoda-Smith S, Torgerson TR, Xu M, Burroughs LM, Woolfrey AE, Fleming MD, Shimamura A. Severe combined immunodeficiency (SCID) presenting with neonatal aplastic anemia. Pediatr Blood Cancer. 2015 Nov; 62(11):2047-9. PMID: 26011426.
    Citations:    Fields:    Translation:Humans
  52. Huang Y, Gloviczki P, Oderich GS, Duncan AA, Kalra M, Fleming MD, Harmsen WS, Bower TC. Outcome after open and endovascular repairs of abdominal aortic aneurysms in matched cohorts using propensity score modeling. J Vasc Surg. 2015 Aug; 62(2):304-11.e2. PMID: 25943452.
    Citations: 3     Fields:    Translation:Humans
  53. Schmidt PJ, Racie T, Westerman M, Fitzgerald K, Butler JS, Fleming MD. Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of ß-thalassemia intermedia. Am J Hematol. 2015 Apr; 90(4):310-3. PMID: 25557851.
    Citations: 13     Fields:    Translation:Animals
  54. Rana MA, Gloviczki P, Kalra M, Bjarnason H, Huang Y, Fleming MD. Open surgical removal of retained and dislodged inferior vena cava filters. J Vasc Surg Venous Lymphat Disord. 2015 Apr; 3(2):201-6. PMID: 26993841.
    Citations: 2     Fields:    Translation:Humans
  55. Fleming MD, Lall P, Nagorney DM, Gloviczki P, Kalra M, Duncan A, Oderich G, Toomey B, Bower TC. Operative interventions for extrahepatic portomesenteric venous aneurysms and long-term outcomes. Ann Vasc Surg. 2015; 29(4):654-60. PMID: 25770384.
    Citations:    Fields:    Translation:Humans
  56. Forester CM, Sartain SE, Guo D, Harris MH, Weinberg OK, Fleming MD, London WB, Williams DA, Hofmann I. Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors. Am J Hematol. 2015 Apr; 90(4):320-6. PMID: 25580823.
    Citations: 4     Fields:    Translation:Humans
  57. Sabino J, Polfer E, Tintle S, Jessie E, Fleming M, Martin B, Shashikant M, Valerio IL. A decade of conflict: flap coverage options and outcomes in traumatic war-related extremity reconstruction. Plast Reconstr Surg. 2015 Mar; 135(3):895-902. PMID: 25415277.
    Citations: 5     Fields:    Translation:Humans
  58. Valerio IL, Campbell P, Sabino J, Lucas DJ, Jessie E, Rodriguez C, Fleming M. TXA in combat casualty care--does it adversely affect extremity reconstruction and flap thrombosis rates? Mil Med. 2015 Mar; 180(3 Suppl):24-8. PMID: 25747626.
    Citations: 1     Fields:    Translation:Humans
  59. Ludwig LS, Cho H, Wakabayashi A, Eng JC, Ulirsch JC, Fleming MD, Lodish HF, Sankaran VG. Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis. Am J Hematol. 2015 May; 90(5):386-91. PMID: 25615569.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  60. Rathkolb B, Klempt M, Sabrautzki S, Michel D, Klaften M, Laufs J, Sedlmeier R, Hans W, Fuchs H, Muckenthaler MU, Horsch M, Campagna DR, Fleming M, Hrabé de Angelis M, Wolf E, Aigner B. Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels. Biometals. 2015 Apr; 28(2):293-306. PMID: 25636453.
    Citations:    Fields:    Translation:AnimalsCells
  61. Gloviczki P, Huang Y, Oderich GS, Duncan AA, Kalra M, Fleming MD, Harmsen WS, Bower TC. Clinical presentation, comorbidities, and age but not female gender predict survival after endovascular repair of abdominal aortic aneurysm. J Vasc Surg. 2015 Apr; 61(4):853-61.e2. PMID: 25595402.
    Citations: 6     Fields:    Translation:Humans
  62. Valerio IL, Campbell P, Sabino J, Dearth CL, Fleming M. The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care. Regen Med. 2015; 10(5):611-22. PMID: 26237704.
    Citations: 6     Fields:    Translation:HumansCells
  63. Gutschow P, Schmidt PJ, Han H, Ostland V, Bartnikas TB, Pettiglio MA, Herrera C, Butler JS, Nemeth E, Ganz T, Fleming MD, Westerman M. A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. Haematologica. 2015 Feb; 100(2):167-77. PMID: 25425686.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  64. Zhang MY, Keel SB, Walsh T, Lee MK, Gulsuner S, Watts AC, Pritchard CC, Salipante SJ, Jeng MR, Hofmann I, Williams DA, Fleming MD, Abkowitz JL, King MC, Shimamura A. Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity. Haematologica. 2015 Jan; 100(1):42-8. PMID: 25239263.
    Citations: 31     Fields:    Translation:Humans
  65. Chakraborty PK, Schmitz-Abe K, Kennedy EK, Mamady H, Naas T, Durie D, Campagna DR, Lau A, Sendamarai AK, Wiseman DH, May A, Jolles S, Connor P, Powell C, Heeney MM, Giardina PJ, Klaassen RJ, Kannengiesser C, Thuret I, Thompson AA, Marques L, Hughes S, Bonney DK, Bottomley SS, Wynn RF, Laxer RM, Minniti CP, Moppett J, Bordon V, Geraghty M, Joyce PB, Markianos K, Rudner AD, Holcik M, Fleming MD. Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). Blood. 2014 Oct 30; 124(18):2867-71. PMID: 25193871.
    Citations: 30     Fields:    Translation:HumansCells
  66. Crompton BD, Stewart C, Taylor-Weiner A, Alexe G, Kurek KC, Calicchio ML, Kiezun A, Carter SL, Shukla SA, Mehta SS, Thorner AR, de Torres C, Lavarino C, Suñol M, McKenna A, Sivachenko A, Cibulskis K, Lawrence MS, Stojanov P, Rosenberg M, Ambrogio L, Auclair D, Seepo S, Blumenstiel B, DeFelice M, Imaz-Rosshandler I, Schwarz-Cruz Y Celis A, Rivera MN, Rodriguez-Galindo C, Fleming MD, Golub TR, Getz G, Mora J, Stegmaier K. The genomic landscape of pediatric Ewing sarcoma. Cancer Discov. 2014 Nov; 4(11):1326-41. PMID: 25186949.
    Citations: 69     Fields:    Translation:HumansCells
  67. Ohgami RS, Sendamarai AK, Atwater SK, Liedtke M, Fleming MD, Natkunam Y, Warnke RA. Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression. Am J Surg Pathol. 2014 Sep; 38(9):1298-304. PMID: 24618611.
    Citations: 2     Fields:    Translation:HumansCells
  68. Valerio I, Sabino J, Thomas S, Tintle S, Fleming M, Shashikant M, Kumar A. Multiple limbs salvaged using tissue transfers in the same casualty: a cohort comparison study chronicling a decade of war-injured patients. Plast Reconstr Surg. 2014 Aug; 134(2):333-8. PMID: 25068331.
    Citations: 1     Fields:    Translation:Humans
  69. Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG. Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6. PMID: 25044010.
    Citations: 9     Fields:    Translation:HumansCells
  70. Bottomley SS, Fleming MD. Sideroblastic anemia: diagnosis and management. Hematol Oncol Clin North Am. 2014 Aug; 28(4):653-70, v. PMID: 25064706.
    Citations: 11     Fields:    Translation:Humans
  71. Gifford SM, Kalra M, Gloviczki P, Duncan AA, Oderich GS, Fleming MD, Harmsen S, Bower TC. Reflux in the below-knee great saphenous vein can be safely treated with endovenous ablation. J Vasc Surg Venous Lymphat Disord. 2014 Oct; 2(4):397-402. PMID: 26993545.
    Citations: 1     Fields:    
  72. Huang Y, Gloviczki P, Oderich GS, Duncan AA, Kalra M, Fleming MD, Harmsen WS, Bower TC. Outcomes of endovascular and contemporary open surgical repairs of popliteal artery aneurysm. J Vasc Surg. 2014 Sep; 60(3):631-8.e2. PMID: 24768361.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  73. Gagne KE, Ghazvinian R, Yuan D, Zon RL, Storm K, Mazur-Popinska M, Andolina L, Bubala H, Golebiowska S, Higman MA, Kalwak K, Kurre P, Matysiak M, Niewiadomska E, Pels S, Petruzzi MJ, Pobudejska-Pieniazek A, Szczepanski T, Fleming MD, Gazda HT, Agarwal S. Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia. Blood. 2014 Jul 17; 124(3):437-40. PMID: 24735966.
    Citations: 6     Fields:    Translation:Humans
  74. Mendes BC, Oderich GS, Fleming MD, Misra S, Duncan AA, Kalra M, Cha S, Gloviczki P. Clinical significance of embolic events in patients undergoing endovascular femoropopliteal interventions with or without embolic protection devices. J Vasc Surg. 2014 Feb; 59(2):359-367.e1. PMID: 24461861.
    Citations: 3     Fields:    Translation:Humans
  75. Schmidt PJ, Fleming MD. Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches. Hematol Oncol Clin North Am. 2014 Apr; 28(2):387-401. PMID: 24589273.
    Citations: 6     Fields:    Translation:HumansAnimals
  76. Bishop A, Fleming M. Patient safety and engagement at the frontlines of healthcare. Healthc Q. 2014; 17 Spec No:36-40. PMID: 25344613.
    Citations:    Fields:    Translation:Humans
  77. Campagna DR, de Bie CI, Schmitz-Abe K, Sweeney M, Sendamarai AK, Schmidt PJ, Heeney MM, Yntema HG, Kannengiesser C, Grandchamp B, Niemeyer CM, Knoers NV, Swart S, Marron G, van Wijk R, Raymakers RA, May A, Markianos K, Bottomley SS, Swinkels DW, Fleming MD. X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations. Am J Hematol. 2014 Mar; 89(3):315-9. PMID: 24166784.
    Citations: 13     Fields:    Translation:HumansCells
  78. Valerio IL, Sabino J, Bevevino A, Tintle SM, Fleming M, Kumar A. Sequential free tissue transfers for simultaneous upper and lower limb salvage. Microsurgery. 2013 Sep; 33(6):447-53. PMID: 24006342.
    Citations: 1     Fields:    Translation:Humans
  79. Lipshultz SE, Lipsitz SR, Kutok JL, Miller TL, Colan SD, Neuberg DS, Stevenson KE, Fleming MD, Sallan SE, Franco VI, Henkel JM, Asselin BL, Athale UH, Clavell LA, Michon B, Laverdiere C, Larsen E, Kelly KM, Silverman LB. Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia. Cancer. 2013 Oct 01; 119(19):3555-62. PMID: 23861158.
    Citations: 28     Fields:    Translation:Humans
  80. Armstrong AJ, Shen T, Halabi S, Kemeny G, Bitting RL, Kartcheske P, Embree E, Morris K, Winters C, Jaffe T, Fleming M, George DJ. A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer. Clin Genitourin Cancer. 2013 Dec; 11(4):397-406. PMID: 23830964.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  81. Manunga JM, Gloviczki P, Oderich GS, Kalra M, Duncan AA, Fleming MD, Bower TC. Femoral artery calcification as a determinant of success for percutaneous access for endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2013 Nov; 58(5):1208-12. PMID: 23830310.
    Citations: 7     Fields:    Translation:Humans
  82. Johnstone JK, Fleming MD, Costopoulos MG, Bjarnason H. Percutaneous removal of a Bard Simon nitinol permanent inferior vena cava filter. Perspect Vasc Surg Endovasc Ther. 2012 Dec; 24(4):198-201. PMID: 23820181.
    Citations:    Fields:    Translation:Humans
  83. Valerio I, Sabino J, Heckert R, Thomas S, Tintle S, Fleming M, Kumar A. Known preoperative deep venous thrombosis and/or pulmonary embolus: to flap or not to flap the severely injured extremity? Plast Reconstr Surg. 2013 Jul; 132(1):213-20. PMID: 23508052.
    Citations: 3     Fields:    Translation:Humans
  84. Cherry AB, Gagne KE, McLoughlin EM, Baccei A, Gorman B, Hartung O, Miller JD, Zhang J, Zon RL, Ince TA, Neufeld EJ, Lerou PH, Fleming MD, Daley GQ, Agarwal S. Induced pluripotent stem cells with a mitochondrial DNA deletion. Stem Cells. 2013 Jul; 31(7):1287-97. PMID: 23400930.
    Citations: 26     Fields:    Translation:HumansCells
  85. Gauss GH, Kleven MD, Sendamarai AK, Fleming MD, Lawrence CM. The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site. J Biol Chem. 2013 Jul 12; 288(28):20668-82. PMID: 23733181.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  86. Wiseman DH, May A, Jolles S, Connor P, Powell C, Heeney MM, Giardina PJ, Klaassen RJ, Chakraborty P, Geraghty MT, Major-Cook N, Kannengiesser C, Thuret I, Thompson AA, Marques L, Hughes S, Bonney DK, Bottomley SS, Fleming MD, Wynn RF. A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD). Blood. 2013 Jul 04; 122(1):112-23. PMID: 23553769.
    Citations: 16     Fields:    Translation:HumansCells
  87. Bartnikas TB, Wildt SJ, Wineinger AE, Schmitz-Abe K, Markianos K, Cooper DM, Fleming MD. A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2. Comp Med. 2013 Apr; 63(2):143-55. PMID: 23582421.
    Citations: 3     Fields:    Translation:AnimalsCells
  88. Crompton BD, Carlton AL, Thorner AR, Christie AL, Du J, Calicchio ML, Rivera MN, Fleming MD, Kohl NE, Kung AL, Stegmaier K. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 01; 73(9):2873-83. PMID: 23536552.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  89. Yuan X, Fleming MD, Hamza I. Heme transport and erythropoiesis. Curr Opin Chem Biol. 2013 Apr; 17(2):204-11. PMID: 23415705.
    Citations: 17     Fields:    Translation:HumansAnimals
  90. White C, Yuan X, Schmidt PJ, Bresciani E, Samuel TK, Campagna D, Hall C, Bishop K, Calicchio ML, Lapierre A, Ward DM, Liu P, Fleming MD, Hamza I. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013 Feb 05; 17(2):261-70. PMID: 23395172.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  91. Anderson SA, Nizzi CP, Chang YI, Deck KM, Schmidt PJ, Galy B, Damnernsawad A, Broman AT, Kendziorski C, Hentze MW, Fleming MD, Zhang J, Eisenstein RS. The IRP1-HIF-2a axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab. 2013 Feb 05; 17(2):282-90. PMID: 23395174.
    Citations: 47     Fields:    Translation:AnimalsCells
  92. Bartnikas TB, Steinbicker AU, Campagna DR, Blevins S, Woodward LS, Herrera C, Bloch KD, Justice MJ, Fleming MD. Identification and characterization of a novel murine allele of Tmprss6. Haematologica. 2013 Jun; 98(6):854-61. PMID: 23300183.
    Citations: 2     Fields:    Translation:AnimalsCells
  93. Schmidt PJ, Toudjarska I, Sendamarai AK, Racie T, Milstein S, Bettencourt BR, Hettinger J, Bumcrot D, Fleming MD. An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine ß-thalassemia intermedia. Blood. 2013 Feb 14; 121(7):1200-8. PMID: 23223430.
    Citations: 46     Fields:    Translation:AnimalsCells
  94. Fleming MD, Hamza I. Mitochondrial heme: an exit strategy at last. J Clin Invest. 2012 Dec; 122(12):4328-30. PMID: 23187133.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  95. Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature. 2012 Nov 22; 491(7425):608-12. PMID: 23135403.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  96. Bear JR, McKay P, Nanos G, Fleming M, Rich N. Vascular injury and concomitant long-bone fracture in war wounds. J Vasc Surg. 2012 Dec; 56(6):1795-8. PMID: 23009831.
    Citations:    Fields:    Translation:Humans
  97. Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, de Wit R, Mulders P, Chi KN, Shore ND, Armstrong AJ, Flaig TW, Fléchon A, Mainwaring P, Fleming M, Hainsworth JD, Hirmand M, Selby B, Seely L, de Bono JS. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012 Sep 27; 367(13):1187-97. PMID: 22894553.
    Citations: 804     Fields:    Translation:HumansCellsCTClinical Trials
  98. Badalian-Very G, Vergilio JA, Fleming M, Rollins BJ. Pathogenesis of Langerhans cell histiocytosis. Annu Rev Pathol. 2013 Jan 24; 8:1-20. PMID: 22906202.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  99. Schmidt PJ, Fleming MD. Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2. Am J Hematol. 2012 Jun; 87(6):588-95. PMID: 22460705.
    Citations: 17     Fields:    Translation:AnimalsCells
  100. Hartnell N, MacKinnon N, Sketris I, Fleming M. Identifying, understanding and overcoming barriers to medication error reporting in hospitals: a focus group study. BMJ Qual Saf. 2012 May; 21(5):361-8. PMID: 22389018.
    Citations: 17     Fields:    Translation:Humans
  101. Bartnikas TB, Parker CC, Cheng R, Campagna DR, Lim JE, Palmer AA, Fleming MD. QTLs for murine red blood cell parameters in LG/J and SM/J F(2) and advanced intercross lines. Mamm Genome. 2012 Jun; 23(5-6):356-66. PMID: 22322356.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  102. Bartnikas TB, Fleming MD, Schmidt PJ. Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances. Biochim Biophys Acta. 2012 Sep; 1823(9):1444-50. PMID: 22306267.
    Citations:    Fields:    Translation:HumansAnimalsCells
  103. Bartnikas TB, Fleming MD. Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice. Haematologica. 2012 Feb; 97(2):189-92. PMID: 21993681.
    Citations: 6     Fields:    Translation:Animals
  104. Anderson DS, Kirchner M, Kellogg M, Kalish LA, Jeong JY, Vanasse G, Berliner N, Fleming MD, Steen H. Design and validation of a high-throughput matrix-assisted laser desorption ionization time-of-flight mass spectrometry method for quantification of hepcidin in human plasma. Anal Chem. 2011 Nov 01; 83(21):8357-62. PMID: 21958231.
    Citations: 3     Fields:    Translation:Humans
  105. Vanasse GJ, Jeong JY, Tate J, Bathulapalli H, Anderson D, Steen H, Fleming M, Mattocks K, Telenti A, Fellay J, Justice AC, Berliner N. A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Blood. 2011 Nov 17; 118(20):5401-8. PMID: 21926355.
    Citations: 1     Fields:    Translation:HumansCells
  106. Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood. 2011 Oct 13; 118(15):4224-30. PMID: 21841161.
    Citations: 61     Fields:    Translation:AnimalsCells
  107. Sironen A, Kotaja N, Mulhern H, Wyatt TA, Sisson JH, Pavlik JA, Miiluniemi M, Fleming MD, Lee L. Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Biol Reprod. 2011 Oct; 85(4):690-701. PMID: 21715716.
    Citations: 15     Fields:    Translation:AnimalsCells
  108. Sundt TM, Fleming MD, Flemming MD, Oderich GS, Torres NE, Li Z, Lenoch J, Kalra M. Spinal cord protection during open repair of thoracic and thoracoabdominal aortic aneurysms using profound hypothermia and circulatory arrest. J Am Coll Surg. 2011 Apr; 212(4):678-83; discussion 684-5. PMID: 21463811.
    Citations: 3     Fields:    Translation:Humans
  109. Fleming MD. Congenital sideroblastic anemias: iron and heme lost in mitochondrial translation. Hematology Am Soc Hematol Educ Program. 2011; 2011:525-31. PMID: 22160084.
    Citations: 25     Fields:    Translation:HumansCells
  110. Bartnikas TB, Campagna DR, Antiochos B, Mulhern H, Pondarré C, Fleming MD. Characterization of mitochondrial ferritin-deficient mice. Am J Hematol. 2010 Dec; 85(12):958-60. PMID: 20960432.
    Citations: 9     Fields:    Translation:Animals
  111. Bartnikas TB, Fleming MD. A tincture of hepcidin cures all: the potential for hepcidin therapeutics. J Clin Invest. 2010 Dec; 120(12):4187-90. PMID: 21099105.
    Citations: 3     Fields:    Translation:HumansAnimals
  112. Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 2010 Oct 19; 18(4):353-66. PMID: 20951945.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  113. Bartnikas TB, Andrews NC, Fleming MD. Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood. 2011 Jan 13; 117(2):630-7. PMID: 20956801.
    Citations: 32     Fields:    Translation:HumansAnimals
  114. Wang J, Liu Y, Li Z, Du J, Ryu MJ, Taylor PR, Fleming MD, Young KH, Pitot H, Zhang J. Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood. 2010 Dec 23; 116(26):5991-6002. PMID: 20921338.
    Citations: 48     Fields:    Translation:AnimalsCells
  115. Galsky MD, Von Hoff DD, Neubauer M, Anderson T, Fleming M, Nagarwala Y, Mahoney JM, Midwinter D, Vocila L, Zaks TZ. Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplified solid tumors. Invest New Drugs. 2012 Apr; 30(2):695-701. PMID: 20857170.
    Citations: 18     Fields:    Translation:HumansCTClinical Trials
  116. Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, Stewart AF, Voight BF, Willenborg C, Wright B, Altshuler D, Arking D, Balkau B, Barnes D, Boerwinkle E, Böhm B, Bonnefond A, Bonnycastle LL, Boomsma DI, Bornstein SR, Böttcher Y, Bumpstead S, Burnett-Miller MS, Campbell H, Cao A, Chambers J, Clark R, Collins FS, Coresh J, de Geus EJ, Dei M, Deloukas P, Döring A, Egan JM, Elosua R, Ferrucci L, Forouhi N, Fox CS, Franklin C, Franzosi MG, Gallina S, Goel A, Graessler J, Grallert H, Greinacher A, Hadley D, Hall A, Hamsten A, Hayward C, Heath S, Herder C, Homuth G, Hottenga JJ, Hunter-Merrill R, Illig T, Jackson AU, Jula A, Kleber M, Knouff CW, Kong A, Kooner J, Köttgen A, Kovacs P, Krohn K, Kühnel B, Kuusisto J, Laakso M, Lathrop M, Lecoeur C, Li M, Li M, Loos RJ, Luan J, Lyssenko V, Mägi R, Magnusson PK, Mälarstig A, Mangino M, Martínez-Larrad MT, März W, McArdle WL, McPherson R, Meisinger C, Meitinger T, Melander O, Mohlke KL, Mooser VE, Morken MA, Narisu N, Nathan DM, Nauck M, O'Donnell C, Oexle K, Olla N, Pankow JS, Payne F, Peden JF, Pedersen NL, Peltonen L, Perola M, Polasek O, Porcu E, Rader DJ, Rathmann W, Ripatti S, Rocheleau G, Roden M, Rudan I, Salomaa V, Saxena R, Schlessinger D, Schunkert H, Schwarz P, Seedorf U, Selvin E, Serrano-Ríos M, Shrader P, Silveira A, Siscovick D, Song K, Spector TD, Stefansson K, Steinthorsdottir V, Strachan DP, Strawbridge R, Stumvoll M, Surakka I, Swift AJ, Tanaka T, Teumer A, Thorleifsson G, Thorsteinsdottir U, Tönjes A, Usala G, Vitart V, Völzke H, Wallaschofski H, Waterworth DM, Watkins H, Wichmann HE, Wild SH, Willemsen G, Williams GH, Wilson JF, Winkelmann J, Wright AF, Zabena C, Zhao JH, Epstein SE, Erdmann J, Hakonarson HH, Kathiresan S, Khaw KT, Roberts R, Samani NJ, Fleming MD, Sladek R, Abecasis G, Boehnke M, Froguel P, Groop L, McCarthy MI, Kao WH, Florez JC, Uda M, Wareham NJ, Barroso I, Meigs JB. Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec; 59(12):3229-39. PMID: 20858683.
    Citations: 141     Fields:    Translation:Humans
  117. Armand P, Kim HT, Rhodes J, Sainvil MM, Cutler C, Ho VT, Koreth J, Alyea EP, Hearsey D, Neufeld EJ, Fleming MD, Steen H, Anderson D, Kwong RY, Soiffer RJ, Antin JH. Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation. Biol Blood Marrow Transplant. 2011 Jun; 17(6):852-60. PMID: 20854920.
    Citations: 17     Fields:    Translation:Humans
  118. Schmidt PJ, Andrews NC, Fleming MD. Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. Blood. 2010 Dec 16; 116(25):5679-87. PMID: 20837779.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  119. Wong TE, Calicchio ML, Fleming MD, Shimamura A, Harris MH. SBDS protein expression patterns in the bone marrow. Pediatr Blood Cancer. 2010 Sep; 55(3):546-9. PMID: 20658628.
    Citations: 4     Fields:    Translation:HumansCells
  120. Moreno JA, Fleming MD, Farnell MB, Gloviczki P. Extrahepatic portal vein aneurysm. J Vasc Surg. 2011 Jul; 54(1):225-6. PMID: 20691558.
    Citations: 3     Fields:    Translation:Humans
  121. Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley GQ. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med. 2010 Aug; 16(8):903-8. PMID: 20616797.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  122. Goy A, Bernstein SH, McDonald A, Pickard MD, Shi H, Fleming MD, Bryant B, Trepicchio W, Fisher RI, Boral AL, Mulligan G. Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial. Leuk Lymphoma. 2010 Jul; 51(7):1269-77. PMID: 20572799.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  123. Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 2010 Sep 16; 116(11):1919-23. PMID: 20519626.
    Citations: 167     Fields:    Translation:Humans
  124. Lizarraga SB, Margossian SP, Harris MH, Campagna DR, Han AP, Blevins S, Mudbhary R, Barker JE, Walsh CA, Fleming MD. Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development. 2010 Jun; 137(11):1907-17. PMID: 20460369.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  125. Chen JH, Fleming MD, Pinkus GS, Pinkus JL, Nichols KE, Mo JQ, Perez-Atayde AR. Pathology of the liver in familial hemophagocytic lymphohistiocytosis. Am J Surg Pathol. 2010 Jun; 34(6):852-67. PMID: 20442642.
    Citations: 4     Fields:    Translation:HumansCells
  126. Finberg KE, Whittlesey RL, Fleming MD, Andrews NC. Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood. 2010 May 06; 115(18):3817-26. PMID: 20200349.
    Citations: 46     Fields:    Translation:AnimalsCells
  127. Freeman AL, Tornetta P, Schmidt A, Bechtold J, Ricci W, Fleming M. How much do locked screws add to the fixation of "hybrid" plate constructs in osteoporotic bone? J Orthop Trauma. 2010 Mar; 24(3):163-9. PMID: 20182252.
    Citations: 4     Fields:    Translation:Humans
  128. Anderson DS, Heeney MM, Roth U, Menzel C, Fleming MD, Steen H. High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine. Anal Chem. 2010 Feb 15; 82(4):1551-5. PMID: 20102179.
    Citations: 6     Fields:    Translation:Humans
  129. Bergmann AK, Campagna DR, McLoughlin EM, Agarwal S, Fleming MD, Bottomley SS, Neufeld EJ. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Pediatr Blood Cancer. 2010 Feb; 54(2):273-8. PMID: 19731322.
    Citations: 37     Fields:    Translation:Humans
  130. Fleming MD, Stone WM, Scott P, Chapital AB, Fowl RJ, Money SR. Safety of carotid endarterectomy in patients concurrently on clopidogrel. Ann Vasc Surg. 2009 Sep-Oct; 23(5):612-5. PMID: 19747611.
    Citations: 1     Fields:    Translation:Humans
  131. Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT. Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22. PMID: 19704007.
    Citations: 14     Fields:    Translation:AnimalsCells
  132. Degar BA, Fleming MD, Rollins BJ. Histiocytoses. Oncology of Infancy and Childhood (Orkin SH, Fisher D, Look AT, Lux SE, Ginsberg D, Nathan DG, editors). 2009.
  133. Guernsey DL, Jiang H, Campagna DR, Evans SC, Ferguson M, Kellogg MD, Lachance M, Matsuoka M, Nightingale M, Rideout A, Saint-Amant L, Schmidt PJ, Orr A, Bottomley SS, Fleming MD, Ludman M, Dyack S, Fernandez CV, Samuels ME. Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet. 2009 Jun; 41(6):651-3. PMID: 19412178.
    Citations: 65     Fields:    Translation:HumansAnimals
  134. Zhang J, Wang J, Liu Y, Sidik H, Young KH, Lodish HF, Fleming MD. Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood. 2009 Feb 05; 113(6):1304-14. PMID: 19066392.
    Citations: 43     Fields:    Translation:AnimalsCells
  135. Andrews NC, Ullrich C, Fleming MD. Iron metabolism and sideroblastic anemias. Nathan and Oski's Hematology of Infancy and Childhood (Orkin SH, Fisher D, Look AT, Lux SE, Ginsberg D, Nathan DG, editors). 2008.
  136. Lambe T, Simpson RJ, Dawson S, Bouriez-Jones T, Crockford TL, Lepherd M, Latunde-Dada GO, Robinson H, Raja KB, Campagna DR, Villarreal G, Ellory JC, Goodnow CC, Fleming MD, McKie AT, Cornall RJ. Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. Blood. 2009 Feb 19; 113(8):1805-8. PMID: 18955558.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  137. Carpenter S, Fraser J, Fleming M, Gray R, Halyard M, Pockaj B. Optimal treatment of multiple ipsilateral primary breast cancers. Am J Surg. 2008 Oct; 196(4):530-6. PMID: 18809057.
    Citations:    Fields:    Translation:Humans
  138. Tian M, Campagna DR, Woodward LS, Justice MJ, Fleming MD. hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse. Blood. 2008 Nov 15; 112(10):4308-13. PMID: 18780836.
    Citations: 4     Fields:    Translation:AnimalsCells
  139. Sendamarai AK, Ohgami RS, Fleming MD, Lawrence CM. Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7410-5. PMID: 18495927.
    Citations: 19     Fields:    Translation:HumansCells
  140. Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M, Hamza I. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature. 2008 Jun 19; 453(7198):1127-31. PMID: 18418376.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  141. Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, Andrews NC, Fleming MD. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet. 2008 May; 40(5):569-71. PMID: 18408718.
    Citations: 175     Fields:    Translation: