Harvard Catalyst Profiles

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Ciaran Patrick Kelly, M.D., M.B.


Available: 07/21/17, Expires: 06/28/21

The Celiac Center at BIDMC is a founding member of the Celiac Program at Harvard Medical School and is active in patient care, education and research in celiac disease and gluten-related disorders. The clinical staff at the center has cared for more than 5,000 patients with celiac disease and sees over 200 newly diagnosed patients annually.

The center maintains a rich database on its patients that has acted as a resource for studies on factors that influence dietary adherences, the burden of treatment of celiac disease, obesity in celiac disease and many others. Multiple additional studies are possible using this database. Ongoing studies also examine new approaches to celiac disease diagnosis, novel therapies and management of non-responsive celiac disease. Translational research studies examine in vitro culture of duodenal biopsies from celiac patients as an approach to developing new diagnostic tools and to provide new insights into disease pathogenesis. Educational initiatives include the www.CeliacNow.org website as well as work with local and national Celiac support organizations to address patients’ health education needs.

Thus, a wide range of potential projects are available depending on the interests of the Scholar. Specific project details and plans will be developed by the scholar working with the Celiac Center Medical Director, Dr Ciaran Kelly, and Research Director, Dr Daniel Leffler.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI095256 (HO, DAVID D) Jul 1, 2012 - Jun 30, 2016
    Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Role: Co-Principal Investigator
  2. R56AI095256 (HO, DAVID D) Sep 30, 2011 - Jun 30, 2012
    Combination Clostridium Difficile Toxin and Adhesin Vaccine
    Role: Co-Principal Investigator
  3. R01AI053069 (KELLY, CIARAN P) Apr 1, 2004 - Mar 31, 2010
    Immune Response to Clostridium difficile
    Role: Principal Investigator
  4. R01DK058858 (KELLY, CIARAN P) Mar 1, 2001 - Feb 28, 2006
    Role: Principal Investigator
  5. T32DK007760 (KELLY, CIARAN P) Jul 1, 1999 - Jun 30, 2014
    Research Training in Gastroenterology
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Silvester JA, Kelly CP, Duerksen DD. Reply to GASTRO-D-20-00033. Gastroenterology. 2020 Jul 18. PMID: 32693184.
  2. Therrien A, Silvester JA, Leonard MM, Leffler DA, Fasano A, Kelly CP. Enteric-Release Budesonide May Be Useful in the Management of Non-Responsive Celiac Disease. Dig Dis Sci. 2020 Jul 11. PMID: 32654085.
  3. Lin Q, Pollock NR, Banz A, Lantz A, Xu H, Gu L, Gerding DN, Garey KW, Gonzales-Luna AJ, Zhao M, Song L, Duffy DC, Kelly CP, Chen X. Toxin A-Predominant Pathogenic Clostridioides difficile: A Novel Clinical Phenotype. Clin Infect Dis. 2020 Jun 10; 70(12):2628-2633. PMID: 31400280.
  4. Pinto-Sanchez MI, Seiler CL, Santesso N, Alaedini A, Semrad C, Lee AR, Bercik P, Lebwohl B, Leffler DA, Kelly CP, Moayyedi P, Green PH, Verdu EF. Association Between Inflammatory Bowel Diseases and Celiac Disease: A Systematic Review and Meta-Analysis. Gastroenterology. 2020 May 08. PMID: 32416141.
  5. Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N, Conner ME, Savidge T, Kelly CP. Natural Clostridioides difficile Toxin Immunization in Colonized Infants. Clin Infect Dis. 2020 May 06; 70(10):2095-2102. PMID: 31253983.
  6. Kelly CP, Chen X, Williams D, Xu H, Cuddemi CA, Daugherty K, Barrett C, Miller M, Foussadier A, Lantz A, Banz A, Pollock NR. Host Immune Markers Distinguish Clostridioides difficile Infection From Asymptomatic Carriage and Non-C. difficile Diarrhea. Clin Infect Dis. 2020 Mar 03; 70(6):1083-1093. PMID: 31211839.
  7. Therrien A, Kelly CP, Silvester JA. Celiac Disease: Extraintestinal Manifestations and Associated Conditions. J Clin Gastroenterol. 2020 01; 54(1):8-21. PMID: 31513026.
  8. Mendo-Lopez R, Villafuerte-Gálvez J, White N, Mahoney MV, Kelly CP, Alonso CD. Recent developments in the management of recurrent Clostridioides difficile infection. Anaerobe. 2020 Apr; 62:102108. PMID: 31606481.
  9. White NC, Mendo-Lopez R, Papamichael K, Cuddemi CA, Barrett C, Daugherty K, Pollock N, Kelly CP, Alonso CD. Laxative use does not preclude diagnosis or reduce disease severity in Clostridiodes difficile infection. Clin Infect Dis. 2019 Oct 04. PMID: 31584632.
  10. Singh P, Singh A, Silvester JA, Sachdeva V, Chen X, Xu H, Leffler DA, Ahuja V, Duerksen DR, Kelly CP, Makharia GK. Inter- and Intra-assay Variation in the Diagnostic Performance of Assays for Anti-tissue Transglutaminase in 2 Populations. Clin Gastroenterol Hepatol. 2019 Sep 20. PMID: 31546060.
  11. Singh P, Arora A, Strand TA, Leffler DA, Mäki M, Kelly CP, Ahuja V, Makharia GK. Diagnostic Accuracy of Point of Care Tests for Diagnosing Celiac Disease: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2019 08; 53(7):535-542. PMID: 29912751.
    Citations:    Fields:    
  12. Alhassan E, Yadav A, Kelly CP, Mukherjee R. Novel Nondietary Therapies for Celiac Disease. Cell Mol Gastroenterol Hepatol. 2019; 8(3):335-345. PMID: 31146067.
  13. Therrien A, Silvester JA, Leffler DA, Kelly CP. Efficacy of Enteric-Release Oral Budesonide in Treatment of Acute Reactions to Gluten in Patients With Celiac Disease. Clin Gastroenterol Hepatol. 2020 01; 18(1):254-256. PMID: 30905717.
  14. Kelly CP, Chong Nguyen C, Palmieri LJ, Pallav K, Dowd SE, Humbert L, Seksik P, Bado A, Coffin B, Rainteau D, Kabbani T, Duboc H. Saccharomyces boulardii CNCM I-745 Modulates the Fecal Bile Acids Metabolism During Antimicrobial Therapy in Healthy Volunteers. Front Microbiol. 2019; 10:336. PMID: 30881353.
  15. Pollock NR, Banz A, Chen X, Williams D, Xu H, Cuddemi CA, Cui AX, Perrotta M, Alhassan E, Riou B, Lantz A, Miller MA, Kelly CP. Comparison of Clostridioides difficile Stool Toxin Concentrations in Adults With Symptomatic Infection and Asymptomatic Carriage Using an Ultrasensitive Quantitative Immunoassay. Clin Infect Dis. 2019 01 01; 68(1):78-86. PMID: 29788296.
    Citations: 1     Fields:    
  16. Serena G, Kelly CP, Fasano A. Nondietary Therapies for Celiac Disease. Gastroenterol Clin North Am. 2019 03; 48(1):145-163. PMID: 30711207.
  17. McDonald LC, Johnson S, Bakken JS, Garey KW, Kelly C, Gerding DN. Reply to Fabre et al. Clin Infect Dis. 2018 11 28; 67(12):1958-1959. PMID: 29860268.
    Citations:    Fields:    
  18. Wang S, Wang Y, Cai Y, Kelly CP, Sun X. Novel Chimeric Protein Vaccines Against Clostridium difficile Infection. Front Immunol. 2018; 9:2440. PMID: 30405630.
  19. Džunková M, Moya A, Chen X, Kelly C, D'Auria G. Detection of mixed-strain infections by FACS and ultra-low input genome sequencing. Gut Microbes. 2020 05 03; 11(3):305-309. PMID: 30289342.
    Citations:    Fields:    
  20. Gerding DN, Kelly CP, Rahav G, Lee C, Dubberke ER, Kumar PN, Yacyshyn B, Kao D, Eves K, Ellison MC, Hanson ME, Guris D, Dorr MB. Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection in Patients at Increased Risk for Recurrence. Clin Infect Dis. 2018 08 16; 67(5):649-656. PMID: 29538686.
    Citations: 2     Fields:    
  21. Wang Y, Wang S, Kelly CP, Feng H, Greenberg A, Sun X. TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection. Infect Immun. 2018 08; 86(8). PMID: 29844241.
    Citations:    Fields:    
  22. Chen X, Kelly CP. On and Off: A Dual Role for Cysteine Protease Autoprocessing of C difficile Toxin B on Cytotoxicity vs Proinflammatory Toxin Actions? Cell Mol Gastroenterol Hepatol. 2018; 5(4):654-655. PMID: 29713672.
  23. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, Loo V, Shaklee Sammons J, Sandora TJ, Wilcox MH. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018 03 19; 66(7):987-994. PMID: 29562266.
    Citations: 12     Fields:    
  24. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, Loo V, Shaklee Sammons J, Sandora TJ, Wilcox MH. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018 03 19; 66(7):e1-e48. PMID: 29462280.
    Citations: 17     Fields:    
  25. Singh P, Arora A, Strand TA, Leffler DA, Catassi C, Green PH, Kelly CP, Ahuja V, Makharia GK. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2018 06; 16(6):823-836.e2. PMID: 29551598.
    Citations: 6     Fields:    
  26. Koon HW, Wang J, Mussatto CC, Ortiz C, Lee EC, Tran DH, Chen X, Kelly CP, Pothoulakis C. Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B-Mediated Inflammatory Responses via Inhibition of NF-?B Activity. Antimicrob Agents Chemother. 2018 01; 62(1). PMID: 29038278.
    Citations: 1     Fields:    
  27. Hughey JJ, Ray BK, Lee AR, Voorhees KN, Kelly CP, Schuppan D. Self-reported dietary adherence, disease-specific symptoms, and quality of life are associated with healthcare provider follow-up in celiac disease. BMC Gastroenterol. 2017 Dec 11; 17(1):156. PMID: 29228908.
    Citations:    Fields:    Translation:Humans
  28. Yu H, Chen K, Sun Y, Carter M, Garey KW, Savidge TC, Devaraj S, Tessier ME, von Rosenvinge EC, Kelly CP, Pasetti MF, Feng H. Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity. Clin Vaccine Immunol. 2017 Aug; 24(8). PMID: 28592627.
    Citations: 1     Fields:    Translation:HumansCells
  29. Tian N, Faller L, Leffler DA, Kelly CP, Hansen J, Bosch JA, Wei G, Paster BJ, Schuppan D, Helmerhorst EJ. Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients. Appl Environ Microbiol. 2017 03 15; 83(6). PMID: 28087531.
    Citations: 3     Fields:    Translation:HumansCells
  30. Mahadev S, Murray JA, Wu TT, Chandan VS, Torbenson MS, Kelly CP, Maki M, Green PH, Adelman D, Lebwohl B. Factors associated with villus atrophy in symptomatic coeliac disease patients on a gluten-free diet. Aliment Pharmacol Ther. 2017 04; 45(8):1084-1093. PMID: 28220520.
    Citations: 3     Fields:    Translation:Humans
  31. Wilcox MH, Gerding DN, Poxton IR, Kelly C, Nathan R, Birch T, Cornely OA, Rahav G, Bouza E, Lee C, Jenkin G, Jensen W, Kim YS, Yoshida J, Gabryelski L, Pedley A, Eves K, Tipping R, Guris D, Kartsonis N, Dorr MB. Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection. N Engl J Med. 2017 01 26; 376(4):305-317. PMID: 28121498.
    Citations: 53     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  32. Patel I, Wungjiranirun M, Theethira T, Villafuerte-Galvez J, Castillo N, Akbari M, Alonso CD, Leffler DA, Kelly CP. Lack of adherence to SHEA-IDSA treatment guidelines for Clostridium difficile infection is associated with increased mortality. J Antimicrob Chemother. 2017 02; 72(2):574-581. PMID: 28115504.
    Citations: 2     Fields:    Translation:HumansCells
  33. Koon HW, Su B, Xu C, Mussatto CC, Tran DH, Lee EC, Ortiz C, Wang J, Lee JE, Ho S, Chen X, Kelly CP, Pothoulakis C. Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G610-G623. PMID: 27514478.
    Citations: 3     Fields:    Translation:AnimalsCells
  34. Rubio-Tapia A, Malamut G, Verbeek WH, van Wanrooij RL, Leffler DA, Niveloni SI, Arguelles-Grande C, Lahr BD, Zinsmeister AR, Murray JA, Kelly CP, Bai JC, Green PH, Daum S, Mulder CJ, Cellier C. Creation of a model to predict survival in patients with refractory coeliac disease using a multinational registry. Aliment Pharmacol Ther. 2016 10; 44(7):704-14. PMID: 27485029.
    Citations: 1     Fields:    Translation:HumansCells
  35. Kurada S, Veeraraghavan G, Kaswala D, Hansen J, Cohen D, Kelly C, Leffler D. Low testosterone in non-responsive coeliac disease: A case series, case-control study with comparisons to the National Health and Nutrition Examination Survey. Dig Liver Dis. 2016 Oct; 48(10):1155-61. PMID: 27378706.
    Citations:    Fields:    Translation:Humans
  36. Džunková M, Moya A, Vázquez-Castellanos JF, Artacho A, Chen X, Kelly C, D'Auria G. Active and Secretory IgA-Coated Bacterial Fractions Elucidate Dysbiosis in Clostridium difficile Infection. mSphere. 2016 May-Jun; 1(3). PMID: 27303742.
    Citations: 2     
  37. Adriaanse MP, Leffler DA, Kelly CP, Schuppan D, Najarian RM, Goldsmith JD, Buurman WA, Vreugdenhil AC. Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge. Am J Gastroenterol. 2016 07; 111(7):1014-22. PMID: 27185075.
    Citations: 3     Fields:    Translation:Humans
  38. Hughes M, Qazi T, Berg A, Weinberg J, Chen X, Kelly CP, Farraye FA. Host Immune Response to Clostridium difficile Infection in Inflammatory Bowel Disease Patients. Inflamm Bowel Dis. 2016 Apr; 22(4):853-61. PMID: 26954708.
    Citations: 2     Fields:    Translation:HumansCells
  39. Wungjiranirun M, Kelly CP, Leffler DA. Current Status of Celiac Disease Drug Development. Am J Gastroenterol. 2016 06; 111(6):779-86. PMID: 27021196.
    Citations: 4     Fields:    Translation:Humans
  40. Pallav K, Xu H, Leffler DA, Kabbani T, Kelly CP. Immunoglobulin A deficiency in celiac disease in the United States. J Gastroenterol Hepatol. 2016 Jan; 31(1):133-7. PMID: 26412412.
    Citations: 4     Fields:    Translation:Humans
  41. Zhang Z, Chen X, Hernandez LD, Lipari P, Flattery A, Chen SC, Kramer S, Polishook JD, Racine F, Cape H, Kelly CP, Therien AG. Correction for Zhang et al., Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection. Infect Immun. 2015 Dec; 83(12):4899. PMID: 26556881.
    Citations:    Fields:    
  42. Tian N, Leffler DA, Kelly CP, Hansen J, Marietta EV, Murray JA, Schuppan D, Helmerhorst EJ. Despite sequence homologies to gluten, salivary proline-rich proteins do not elicit immune responses central to the pathogenesis of celiac disease. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 01; 309(11):G910-7. PMID: 26505973.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  43. Villafuerte-Galvez J, Vanga RR, Dennis M, Hansen J, Leffler DA, Kelly CP, Mukherjee R. Factors governing long-term adherence to a gluten-free diet in adult patients with coeliac disease. Aliment Pharmacol Ther. 2015 Sep; 42(6):753-60. PMID: 26206401.
    Citations: 5     Fields:    Translation:Humans
  44. Akbari M, Vodonos A, Silva G, Wungjiranirun M, Leffler DA, Kelly CP, Novack V. The impact of PCR on Clostridium difficile detection and clinical outcomes. J Med Microbiol. 2015 Sep; 64(9):1082-1086. PMID: 26297376.
    Citations: 2     Fields:    Translation:HumansCells
  45. Castillo NE, Vanga RR, Theethira TG, Rubio-Tapia A, Murray JA, Villafuerte J, Bonder A, Mukherjee R, Hansen J, Dennis M, Kelly CP, Leffler DA. Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US population. Am J Gastroenterol. 2015 Aug; 110(8):1216-22. PMID: 26150087.
    Citations: 2     Fields:    Translation:Humans
  46. Kaswala DH, Veeraraghavan G, Kelly CP, Leffler DA. Celiac Disease: Diagnostic Standards and Dilemmas. Diseases. 2015 Jun 16; 3(2):86-101. PMID: 28943611.
  47. Shields K, Araujo-Castillo RV, Theethira TG, Alonso CD, Kelly CP. Recurrent Clostridium difficile infection: From colonization to cure. Anaerobe. 2015 Aug; 34:59-73. PMID: 25930686.
    Citations: 14     Fields:    Translation:HumansCells
  48. Tian N, Messana I, Leffler DA, Kelly CP, Hansen J, Cabras T, D'Alessandro A, Schuppan D, Castagnola M, Helmerhorst EJ. Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease? Proteomics Clin Appl. 2015 Oct; 9(9-10):953-64. PMID: 25726832.
    Citations: 3     Fields:    Translation:HumansCells
  49. Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H. Identification of toxemia in patients with Clostridium difficile infection. PLoS One. 2015; 10(4):e0124235. PMID: 25885671.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  50. Leffler DA, Kelly CP, Green PH, Fedorak RN, DiMarino A, Perrow W, Rasmussen H, Wang C, Bercik P, Bachir NM, Murray JA. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology. 2015 Jun; 148(7):1311-9.e6. PMID: 25683116.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  51. Kelly CP, Bai JC, Liu E, Leffler DA. Advances in diagnosis and management of celiac disease. Gastroenterology. 2015 May; 148(6):1175-86. PMID: 25662623.
    Citations: 24     Fields:    Translation:HumansAnimals
  52. Zhang Z, Chen X, Hernandez LD, Lipari P, Flattery A, Chen SC, Kramer S, Polishook JD, Racine F, Cape H, Kelly CP, Therien AG. Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection. Infect Immun. 2015 Jan; 83(1):405-16. PMID: 25385797.
    Citations: 9     Fields:    Translation:AnimalsCells
  53. Kabbani TA, Vanga RR, Leffler DA, Villafuerte J, Pallav K, Hansen J, Mukherjee R, Dennis M, Kelly C. Response to Aziz et al. Am J Gastroenterol. 2014 Sep; 109(9):1499-500. PMID: 25196881.
    Citations:    Fields:    Translation:Humans
  54. Shah S, Akbari M, Vanga R, Kelly CP, Hansen J, Theethira T, Tariq S, Dennis M, Leffler DA. Patient perception of treatment burden is high in celiac disease compared with other common conditions. Am J Gastroenterol. 2014 Sep; 109(9):1304-11. PMID: 24980880.
    Citations: 24     Fields:    Translation:Humans
  55. Vanga RR, Kelly CP. Novel therapeutic approaches for celiac disease. Discov Med. 2014 May; 17(95):285-93. PMID: 24882720.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  56. Pallav K, Kabbani T, Tariq S, Vanga R, Kelly CP, Leffler DA. Clinical utility of celiac disease-associated HLA testing. Dig Dis Sci. 2014 Sep; 59(9):2199-206. PMID: 24705698.
    Citations: 8     Fields:    Translation:Humans
  57. Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H. A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice. J Infect Dis. 2014 Sep 15; 210(6):964-72. PMID: 24683195.
    Citations: 23     Fields:    Translation:AnimalsCells
  58. Kabbani TA, Vanga RR, Leffler DA, Villafuerte-Galvez J, Pallav K, Hansen J, Mukherjee R, Dennis M, Kelly CP. Celiac disease or non-celiac gluten sensitivity? An approach to clinical differential diagnosis. Am J Gastroenterol. 2014 May; 109(5):741-6; quiz 747. PMID: 24619056.
    Citations: 15     Fields:    Translation:Humans
  59. Hourigan SK, Chirumamilla SR, Ross T, Golub JE, Rabizadeh S, Saeed SA, Elson CO, Kelly CP, Carroll KC, Oliva-Hemker M, Sears C. Clostridium difficile carriage and serum antitoxin responses in children with inflammatory bowel disease. Inflamm Bowel Dis. 2013 Dec; 19(13):2744-52. PMID: 24145927.
    Citations: 12     Fields:    Translation:HumansCells
  60. Locher HH, Seiler P, Chen X, Schroeder S, Pfaff P, Enderlin M, Klenk A, Fournier E, Hubschwerlen C, Ritz D, Kelly CP, Keck W. In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections. Antimicrob Agents Chemother. 2014; 58(2):892-900. PMID: 24277020.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  61. Chen X, Yang G, Song JH, Xu H, Li D, Goldsmith J, Zeng H, Parsons-Wingerter PA, Reinecker HC, Kelly CP. Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation. PLoS One. 2013; 8(5):e64227. PMID: 23675530.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  62. Srivastava N, VanderLaan PA, Kelly CP, Costa DB. Esophagitis: a novel adverse event of crizotinib in a patient with ALK-positive non-small-cell lung cancer. J Thorac Oncol. 2013 Mar; 8(3):e23-4. PMID: 23407563.
    Citations: 3     Fields:    Translation:Humans
  63. Higa JT, Kelly CP. New drugs and strategies for management of Clostridium difficile colitis. J Intensive Care Med. 2014 Jul-Aug; 29(4):190-9. PMID: 23753229.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  64. Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN. Commentary: larazotide acetate - an exciting new development for coeliac patients? Authors' reply. Aliment Pharmacol Ther. 2013 Feb; 37(4):496-7. PMID: 23336684.
    Citations:    Fields:    Translation:Humans
  65. Kabbani TA, Kelly CP, Betensky RA, Hansen J, Pallav K, Villafuerte-Gálvez JA, Vanga R, Mukherjee R, Novero A, Dennis M, Leffler DA. Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome. Gastroenterology. 2013 May; 144(5):912-917.e1. PMID: 23354016.
    Citations: 11     Fields:    Translation:Humans
  66. Tanpowpong P, Broder-Fingert S, Obuch JC, Rahni DO, Katz AJ, Leffler DA, Kelly CP, Camargo CA. Multicenter study on the value of ICD-9-CM codes for case identification of celiac disease. Ann Epidemiol. 2013 Mar; 23(3):136-42. PMID: 23313264.
    Citations: 8     Fields:    Translation:Humans
  67. Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, Zevallos V, Libermann TA, Dillon S, Freitag TL, Kelly CP, Schuppan D. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med. 2012 Dec 17; 209(13):2395-408. PMID: 23209313.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  68. Panzer RM, Dennis M, Kelly CP, Weir D, Leichtner A, Leffler DA. Navigating the gluten-free diet in college. J Pediatr Gastroenterol Nutr. 2012 Dec; 55(6):740-4. PMID: 22732896.
    Citations: 2     Fields:    Translation:Humans
  69. Kelly CP. Can we identify patients at high risk of recurrent Clostridium difficile infection? Clin Microbiol Infect. 2012 Dec; 18 Suppl 6:21-7. PMID: 23121551.
    Citations: 53     Fields:    Translation:HumansCells
  70. Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN. Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther. 2013 Jan; 37(2):252-62. PMID: 23163616.
    Citations: 33     Fields:    Translation:HumansCells
  71. Tanpowpong P, Obuch JC, Jiang H, McCarty CE, Katz AJ, Leffler DA, Kelly CP, Weir DC, Leichtner AM, Camargo CA. Multicenter study on season of birth and celiac disease: evidence for a new theoretical model of pathogenesis. J Pediatr. 2013 Mar; 162(3):501-4. PMID: 23084709.
    Citations: 3     Fields:    Translation:Humans
  72. Mukherjee R, Kelly CP, Schuppan D. Nondietary therapies for celiac disease. Gastrointest Endosc Clin N Am. 2012 Oct; 22(4):811-31. PMID: 23083995.
    Citations: 6     Fields:    Translation:Humans
  73. Leffler DA, Kelly CP, Abdallah HZ, Colatrella AM, Harris LA, Leon F, Arterburn LA, Paterson BM, Lan ZH, Murray JA. A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am J Gastroenterol. 2012 Oct; 107(10):1554-62. PMID: 22825365.
    Citations: 29     Fields:    Translation:HumansCellsPHPublic Health
  74. Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 2013 Sep; 62(9):1295-305. PMID: 22760006.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  75. Martinez FJ, Leffler DA, Kelly CP. Clostridium difficile outbreaks: prevention and treatment strategies. Risk Manag Healthc Policy. 2012; 5:55-64. PMID: 22826646.
    Citations: 7     
  76. Kelly CP. Current strategies for management of initial Clostridium difficile infection. J Hosp Med. 2012 Mar; 7 Suppl 3:S5-10. PMID: 22407996.
    Citations: 11     Fields:    Translation:HumansCells
  77. Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C. The Oslo definitions for coeliac disease and related terms. Gut. 2013 Jan; 62(1):43-52. PMID: 22345659.
    Citations: 224     Fields:    Translation:Humans
  78. Kabbani TA, Goldberg A, Kelly CP, Pallav K, Tariq S, Peer A, Hansen J, Dennis M, Leffler DA. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther. 2012 Mar; 35(6):723-9. PMID: 22316503.
    Citations: 33     Fields:    Translation:Humans
  79. Pallav K, Leffler DA, Bennett M, Tariq S, Xu H, Kabbani T, Moss AC, Dennis M, Kelly CP, Schuppan D. Open conformation tissue transglutaminase testing for celiac dietary assessment. Dig Liver Dis. 2012 May; 44(5):375-8. PMID: 22261352.
    Citations: 2     Fields:    Translation:Humans
  80. Pallav K, Leffler DA, Tariq S, Kabbani T, Hansen J, Peer A, Bhansali A, Najarian R, Kelly CP. Noncoeliac enteropathy: the differential diagnosis of villous atrophy in contemporary clinical practice. Aliment Pharmacol Ther. 2012 Feb; 35(3):380-90. PMID: 22145590.
    Citations: 22     Fields:    Translation:Humans
  81. Na X, Kelly C. Probiotics in clostridium difficile Infection. J Clin Gastroenterol. 2011 Nov; 45 Suppl:S154-8. PMID: 21992956.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  82. Floch MH, Walker WA, Madsen K, Sanders ME, Macfarlane GT, Flint HJ, Dieleman LA, Ringel Y, Guandalini S, Kelly CP, Brandt LJ. Recommendations for probiotic use-2011 update. J Clin Gastroenterol. 2011 Nov; 45 Suppl:S168-71. PMID: 21992958.
    Citations: 52     Fields:    Translation:Humans
  83. Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum of refractory celiac disease in a north american referral center. Am J Gastroenterol. 2011 May; 106(5):923-8. PMID: 21468013.
    Citations: 25     Fields:    Translation:Humans
  84. Kelly CP, Kyne L. The host immune response to Clostridium difficile. J Med Microbiol. 2011 Aug; 60(Pt 8):1070-1079. PMID: 21415200.
    Citations: 43     Fields:    Translation:HumansCells
  85. Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan DB, Sheth S, Kelly CP. Small intestinal release mesalamine for the treatment of refractory celiac disease type I. J Clin Gastroenterol. 2011 Jan; 45(1):30-3. PMID: 20871406.
    Citations: 6     Fields:    Translation:Humans
  86. Leffler DA, Kheraj R, Garud S, Neeman N, Nathanson LA, Kelly CP, Sawhney M, Landon B, Doyle R, Rosenberg S, Aronson M. The incidence and cost of unexpected hospital use after scheduled outpatient endoscopy. Arch Intern Med. 2010 Oct 25; 170(19):1752-7. PMID: 20975024.
    Citations: 17     Fields:    Translation:Humans
  87. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010 May; 31(5):431-55. PMID: 20307191.
    Citations: 692     Fields:    Translation:HumansCellsPHPublic Health
  88. Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Najarian R, Sheth S, Schuppan D, Dennis M, Leffler DA. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol. 2010 Jul; 8(7):587-90. PMID: 20417725.
    Citations: 16     Fields:    Translation:Humans
  89. Kelly CP. Large intestine. Curr Opin Gastroenterol. 2010 Jan; 26(1):45-6. PMID: 19881344.
    Citations:    Fields:    Translation:Humans
  90. Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly CP, Ewoldt RH, McKinley GH, So P, Erramilli S, Bansil R. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14321-6. PMID: 19706518.
    Citations: 71     Fields:    Translation:AnimalsCells
  91. Freitag TL, Rietdijk S, Junker Y, Popov Y, Bhan AK, Kelly CP, Terhorst C, Schuppan D. Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice. Gut. 2009 Dec; 58(12):1597-605. PMID: 19671544.
    Citations: 6     Fields:    Translation:AnimalsCells
  92. Leffler DA, Dennis M, Edwards George J, Jamma S, Cook EF, Schuppan D, Kelly CP. A validated disease-specific symptom index for adults with celiac disease. Clin Gastroenterol Hepatol. 2009 Dec; 7(12):1328-34, 1334.e1-3. PMID: 19665584.
    Citations: 20     Fields:    Translation:Humans
  93. Lembo AJ, Ganz RA, Sheth S, Cave D, Kelly C, Levin P, Kazlas PT, Baldwin PC, Lindmark WR, McGrath JR, Hamblin MR. Treatment of Helicobacter pylori infection with intra-gastric violet light phototherapy: a pilot clinical trial. Lasers Surg Med. 2009 Jul; 41(5):337-44. PMID: 19533762.
    Citations: 15     Fields:    Translation:HumansCells
  94. Cloud J, Noddin L, Pressman A, Hu M, Kelly C. Clostridium difficile strain NAP-1 is not associated with severe disease in a nonepidemic setting. Clin Gastroenterol Hepatol. 2009 Aug; 7(8):868-873.e2. PMID: 19465153.
    Citations: 37     Fields:    Translation:HumansCells
  95. Hyett B, Martinez FJ, Gill BM, Mehra S, Lembo A, Kelly CP, Leffler DA. Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis. Gastroenterology. 2009 Aug; 137(2):445-52. PMID: 19410575.
    Citations: 33     Fields:    Translation:Humans
  96. Garud S, Leffler D, Dennis M, Edwards-George J, Saryan D, Sheth S, Schuppan D, Jamma S, Kelly CP. Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States. Aliment Pharmacol Ther. 2009 Apr 15; 29(8):898-905. PMID: 19183153.
    Citations: 15     Fields:    Translation:Humans
  97. Edwards George JB, Leffler DA, Dennis MD, Franko DL, Blom-Hoffman J, Kelly CP. Psychological correlates of gluten-free diet adherence in adults with celiac disease. J Clin Gastroenterol. 2009 Apr; 43(4):301-6. PMID: 18580599.
    Citations: 6     Fields:    Translation:Humans
  98. Kelly CP. A 76-year-old man with recurrent Clostridium difficile-associated diarrhea: review of C. difficile infection. JAMA. 2009 Mar 04; 301(9):954-62. PMID: 19190304.
    Citations: 29     Fields:    Translation:HumansCells
  99. Leffler DA, Dennis M, Edwards George JB, Jamma S, Magge S, Cook EF, Schuppan D, Kelly CP. A simple validated gluten-free diet adherence survey for adults with celiac disease. Clin Gastroenterol Hepatol. 2009 May; 7(5):530-6, 536.e1-2. PMID: 19268725.
    Citations: 39     Fields:    Translation:Humans
  100. Keates AC, Tummala S, Peek RM, Csizmadia E, Kunzli B, Becker K, Correa P, Romero-Gallo J, Piazuelo MB, Sheth S, Kelly CP, Robson SC, Keates S. Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells. Infect Immun. 2008 Sep; 76(9):3992-9. PMID: 18519558.
    Citations: 9     Fields:    Translation:HumansCells
  101. Leffler DA, Edwards-George J, Dennis M, Schuppan D, Cook F, Franko DL, Blom-Hoffman J, Kelly CP. Factors that influence adherence to a gluten-free diet in adults with celiac disease. Dig Dis Sci. 2008 Jun; 53(6):1573-81. PMID: 17990115.
    Citations: 33     Fields:    Translation:Humans
  102. Taylor CP, Tummala S, Molrine D, Davidson L, Farrell RJ, Lembo A, Hibberd PL, Lowy I, Kelly CP. Open-label, dose escalation phase I study in healthy volunteers to evaluate the safety and pharmacokinetics of a human monoclonal antibody to Clostridium difficile toxin A. Vaccine. 2008 Jun 25; 26(27-28):3404-9. PMID: 18502001.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  103. Leffler DA, Edwards George JB, Dennis M, Cook EF, Schuppan D, Kelly CP. A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac disease. Aliment Pharmacol Ther. 2007 Nov 01; 26(9):1227-35. PMID: 17944737.
    Citations: 28     Fields:    Translation:Humans
  104. Garud S, Brown A, Cheifetz A, Levitan EB, Kelly CP. Meta-analysis of the placebo response in ulcerative colitis. Dig Dis Sci. 2008 Apr; 53(4):875-91. PMID: 17934839.
    Citations: 2     Fields:    Translation:Humans
  105. Kelly CP. Playing host to the difficult Clostridium. Clin Gastroenterol Hepatol. 2007 Aug; 5(8):912-4. PMID: 17678842.
    Citations:    Fields:    Translation:HumansAnimalsCells
  106. Kelly CP. Protease-activated receptor 2 in the intestinal inflammatory response induced by Clostridium difficile toxin A. Gastroenterology. 2007 Jun; 132(7):2599-601. PMID: 17570231.
    Citations:    Fields:    Translation:HumansAnimals
  107. Keates S, Keates AC, Katchar K, Peek RM, Kelly CP. Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis. 2007 Jul 01; 196(1):95-103. PMID: 17538889.
    Citations: 18     Fields:    Translation:HumansCells
  108. Leffler DA, Dennis M, Hyett B, Kelly E, Schuppan D, Kelly CP. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol. 2007 Apr; 5(4):445-50. PMID: 17382600.
    Citations: 64     Fields:    Translation:Humans
  109. Ghose C, Kalsy A, Sheikh A, Rollenhagen J, John M, Young J, Rollins SM, Qadri F, Calderwood SB, Kelly CP, Ryan ET. Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice. Infect Immun. 2007 Jun; 75(6):2826-32. PMID: 17371854.
    Citations: 25     Fields:    Translation:AnimalsCellsPHPublic Health
  110. Leffler DA, Dennis M, Edwards George JB, Kelly CP. The interaction between eating disorders and celiac disease: an exploration of 10 cases. Eur J Gastroenterol Hepatol. 2007 Mar; 19(3):251-5. PMID: 17301653.
    Citations: 7     Fields:    Translation:Humans
  111. Cloud J, Kelly CP. Update on Clostridium difficile associated disease. Curr Opin Gastroenterol. 2007 Jan; 23(1):4-9. PMID: 17133077.
    Citations: 39     Fields:    Translation:HumansCells
  112. Schuppan D, Kelly CP, Krauss N. Monitoring non-responsive patients with celiac disease. Gastrointest Endosc Clin N Am. 2006 Jul; 16(3):593-603. PMID: 16876729.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  113. Leffler D, Cloud JW, Kelly CP. Gastric acid-suppressive agents and risk of Clostridium difficile-associated disease. JAMA. 2006 Jun 14; 295(22):2599-600; author reply 2600-1. PMID: 16772617.
    Citations: 3     Fields:    Translation:HumansCells
  114. Leffler DA, Kelly CP. Update on the evaluation and diagnosis of celiac disease. Curr Opin Allergy Clin Immunol. 2006 Jun; 6(3):191-6. PMID: 16670513.
    Citations: 2     Fields:    Translation:Humans
  115. Keates S, Keates AC, Nath S, Peek RM, Kelly CP. Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut. 2005 Oct; 54(10):1363-9. PMID: 15863471.
    Citations: 16     Fields:    Translation:HumansCells
  116. Schuppan D, Dennis MD, Kelly CP. Celiac disease: epidemiology, pathogenesis, diagnosis, and nutritional management. Nutr Clin Care. 2005 Apr-Jun; 8(2):54-69. PMID: 16013224.
    Citations: 16     Fields:    Translation:Humans
  117. Guandalini S, Guiadalini S, Kelly CP. Toward optimal health: Stefano Guandalini [corrected] M.D., and Ciaran P. Kelly, M.D. Discuss celiac disease. Interview by Jodi R Godfrey. J Womens Health (Larchmt). 2005 Mar; 14(2):110-6. PMID: 15775728.
    Citations: 1     Fields:    Translation:Humans
  118. Zaman MM, Gelrud A, Junaidi O, Regan MM, Warny M, Shea JC, Kelly C, O'Sullivan BP, Freedman SD. Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered. Clin Diagn Lab Immunol. 2004 Sep; 11(5):819-24. PMID: 15358638.
    Citations: 23     Fields:    Translation:HumansCells
  119. Sougioultzis S, Lee CK, Alsahli M, Banerjee S, Cadoz M, Schrader R, Guy B, Bedford P, Monath TP, Kelly CP, Michetti P. Safety and efficacy of E coli enterotoxin adjuvant for urease-based rectal immunization against Helicobacter pylori. Vaccine. 2002 Dec 13; 21(3-4):194-201. PMID: 12450694.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  120. Banerjee S, Medina-Fatimi A, Nichols R, Tendler D, Michetti M, Simon J, Kelly CP, Monath TP, Michetti P. Safety and efficacy of low dose Escherichia coli enterotoxin adjuvant for urease based oral immunisation against Helicobacter pylori in healthy volunteers. Gut. 2002 Nov; 51(5):634-40. PMID: 12377799.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials
  121. Farrell RJ, Menconi MJ, Keates AC, Kelly CP. P-glycoprotein-170 inhibition significantly reduces cortisol and ciclosporin efflux from human intestinal epithelial cells and T lymphocytes. Aliment Pharmacol Ther. 2002 May; 16(5):1021-31. PMID: 11966513.
    Citations: 10     Fields:    Translation:HumansCells
  122. Tendler DA, Aboudola S, Zacks JF, O'Brien MJ, Kelly CP. Prolapsing mucosal polyps: an underrecognized form of colonic polyp--a clinicopathological study of 15 cases. Am J Gastroenterol. 2002 Feb; 97(2):370-6. PMID: 11866275.
    Citations: 14     Fields:    Translation:Humans
  123. Farrell RJ, Kelly CP. Diagnosis of celiac sprue. Am J Gastroenterol. 2001 Dec; 96(12):3237-46. PMID: 11774931.
    Citations: 24     Fields:    Translation:Humans
  124. Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM, Shaw LM, Kelly CP. cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem. 2001 Dec 21; 276(51):48127-34. PMID: 11604402.
    Citations: 61     Fields:    Translation:HumansCells
  125. Zhao D, Keates AC, Kuhnt-Moore S, Moyer MP, Kelly CP, Pothoulakis C. Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes. J Biol Chem. 2001 Nov 30; 276(48):44464-71. PMID: 11574537.
    Citations: 38     Fields:    Translation:HumansCells
  126. Keates AC, Keates S, Kwon JH, Arseneau KO, Law DJ, Bai L, Merchant JL, Wang TC, Kelly CP. ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2001 Nov 23; 276(47):43713-22. PMID: 11559712.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  127. Kyne L, Farrell RJ, Kelly CP. Clostridium difficile. Gastroenterol Clin North Am. 2001 Sep; 30(3):753-77, ix-x. PMID: 11586556.
    Citations: 24     Fields:    Translation:HumansCells
  128. Kyne L, Kelly CP. Recurrent Clostridium difficile diarrhoea. Gut. 2001 Jul; 49(1):152-3. PMID: 11413124.
    Citations: 14     Fields:    Translation:Humans
  129. Warny M, Aboudola S, Robson SC, Sévigny J, Communi D, Soltoff SP, Kelly CP. P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem. 2001 Jul 13; 276(28):26051-6. PMID: 11349132.
    Citations: 58     Fields:    Translation:HumansCells
  130. Qamar A, Aboudola S, Warny M, Michetti P, Pothoulakis C, LaMont JT, Kelly CP. Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice. Infect Immun. 2001 Apr; 69(4):2762-5. PMID: 11254650.
    Citations: 31     Fields:    Translation:AnimalsPHPublic Health
  131. Kyne L, Warny M, Qamar A, Kelly CP. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet. 2001 Jan 20; 357(9251):189-93. PMID: 11213096.
    Citations: 182     Fields:    Translation:HumansCells
  132. Keates AC, Castagliuolo I, Cruickshank WW, Qiu B, Arseneau KO, Brazer W, Kelly CP. Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice. Gastroenterology. 2000 Oct; 119(4):972-82. PMID: 11040184.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  133. Michetti M, Kelly CP, Kraehenbuhl JP, Bouzourene H, Michetti P. Gastric mucosal alpha(4)beta(7)-integrin-positive CD4 T lymphocytes and immune protection against helicobacter infection in mice. Gastroenterology. 2000 Jul; 119(1):109-18. PMID: 10889160.
    Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
  134. Warny M, Keates AC, Keates S, Castagliuolo I, Zacks JK, Aboudola S, Qamar A, Pothoulakis C, LaMont JT, Kelly CP. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest. 2000 Apr; 105(8):1147-56. PMID: 10772660.
    Citations: 67     Fields:    Translation:AnimalsCells
  135. Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med. 2000 Feb 10; 342(6):390-7. PMID: 10666429.
    Citations: 234     Fields:    Translation:HumansCells
  136. Keates S, Keates AC, Warny M, Peek RM, Murray PG, Kelly CP. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J Immunol. 1999 Nov 15; 163(10):5552-9. PMID: 10553083.
    Citations: 68     Fields:    Translation:HumansCells
  137. Warny M, Kelly CP. Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases. Am J Physiol. 1999 03; 276(3):C717-24. PMID: 10070000.
    Citations: 26     Fields:    Translation:HumansCells
  138. Warny M, Fatimi A, Bostwick EF, Laine DC, Lebel F, LaMont JT, Pothoulakis C, Kelly CP. Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut. 1999 Feb; 44(2):212-7. PMID: 9895380.
    Citations: 26     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  139. Bliss CM, Golenbock DT, Keates S, Linevsky JK, Kelly CP. Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun. 1998 Nov; 66(11):5357-63. PMID: 9784544.
    Citations: 24     Fields:    Translation:HumansCells
  140. Kyne L, Kelly CP. Prospects for a vaccine for Clostridium difficile. BioDrugs. 1998 Sep; 10(3):173-81. PMID: 18020593.
    Citations: 5     Fields:    
  141. Castagliuolo I, Keates AC, Wang CC, Pasha A, Valenick L, Kelly CP, Nikulasson ST, LaMont JT, Pothoulakis C. Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells. J Immunol. 1998 Jun 15; 160(12):6039-45. PMID: 9637520.
    Citations: 28     Fields:    Translation:AnimalsCells
  142. Kelly CP, LaMont JT. Clostridium difficile infection. Annu Rev Med. 1998; 49:375-90. PMID: 9509270.
    Citations: 102     Fields:    Translation:HumansCells
  143. Linevsky JK, Pothoulakis C, Keates S, Warny M, Keates AC, Lamont JT, Kelly CP. IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. Am J Physiol. 1997 12; 273(6):G1333-40. PMID: 9435559.
    Citations: 27     Fields:    Translation:HumansCells
  144. Keates S, Hitti YS, Upton M, Kelly CP. Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology. 1997 Oct; 113(4):1099-109. PMID: 9322504.
    Citations: 95     Fields:    Translation:HumansCells
  145. Salcedo J, Keates S, Pothoulakis C, Warny M, Castagliuolo I, LaMont JT, Kelly CP. Intravenous immunoglobulin therapy for severe Clostridium difficile colitis. Gut. 1997 Sep; 41(3):366-70. PMID: 9378393.
    Citations: 57     Fields:    Translation:HumansCells
  146. Castagliuolo I, Kelly CP, Qiu BS, Nikulasson ST, LaMont JT, Pothoulakis C. IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum. Am J Physiol. 1997 Aug; 273(2 Pt 1):G333-41. PMID: 9277411.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  147. Keates S, Keates AC, Mizoguchi E, Bhan A, Kelly CP. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol. 1997 Jul; 273(1 Pt 1):G75-82. PMID: 9252512.
    Citations: 27     Fields:    Translation:HumansCells
  148. Castagliuolo I, Keates AC, Qiu B, Kelly CP, Nikulasson S, Leeman SE, Pothoulakis C. Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4788-93. PMID: 9114070.
    Citations: 45     Fields:    Translation:AnimalsCells
  149. Kelly CP, Chetham S, Keates S, Bostwick EF, Roush AM, Castagliuolo I, LaMont JT, Pothoulakis C. Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract. Antimicrob Agents Chemother. 1997 Feb; 41(2):236-41. PMID: 9021173.
    Citations: 18     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  150. Kelly CP. Cell death and clostridium difficile toxins: the murder weapon uncovered. Inflamm Bowel Dis. 1997; 3(2):177-8. PMID: 23282760.
    Citations:    Fields:    
  151. Kelly CP. Immune response to Clostridium difficile infection. Eur J Gastroenterol Hepatol. 1996 Nov; 8(11):1048-53. PMID: 8944364.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  152. Pothoulakis C, Gilbert RJ, Cladaras C, Castagliuolo I, Semenza G, Hitti Y, Montcrief JS, Linevsky J, Kelly CP, Nikulasson S, Desai HP, Wilkins TD, LaMont JT. Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A. J Clin Invest. 1996 Aug 01; 98(3):641-9. PMID: 8698855.
    Citations: 29     Fields:    Translation:AnimalsCells
  153. Pothoulakis C, Galili U, Castagliuolo I, Kelly CP, Nikulasson S, Dudeja PK, Brasitus TA, LaMont JT. A human antibody binds to alpha-galactose receptors and mimics the effects of Clostridium difficile toxin A in rat colon. Gastroenterology. 1996 Jun; 110(6):1704-12. PMID: 8964394.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  154. Kelly CP, Pothoulakis C, Vavva F, Castagliuolo I, Bostwick EF, O'Keane JC, Keates S, LaMont JT. Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins. Antimicrob Agents Chemother. 1996 Feb; 40(2):373-9. PMID: 8834883.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  155. Kelly CP, Keates S, Siegenberg D, Linevsky JK, Pothoulakis C, Brady HR. IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells. Am J Physiol. 1994 Dec; 267(6 Pt 1):G991-7. PMID: 7810667.
    Citations: 14     Fields:    Translation:HumansCells
  156. Kelly CP, Becker S, Linevsky JK, Joshi MA, O'Keane JC, Dickey BF, LaMont JT, Pothoulakis C. Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit. J Clin Invest. 1994 Mar; 93(3):1257-65. PMID: 7907603.
    Citations: 79     Fields:    Translation:AnimalsCells
  157. Kelly CP, Pothoulakis C, LaMont JT. Clostridium difficile colitis. N Engl J Med. 1994 Jan 27; 330(4):257-62. PMID: 8043060.
    Citations: 239     Fields:    Translation:HumansCells
  158. Pothoulakis C, Karmeli F, Kelly CP, Eliakim R, Joshi MA, O'Keane CJ, Castagliuolo I, LaMont JT, Rachmilewitz D. Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum. Gastroenterology. 1993 Sep; 105(3):701-7. PMID: 8395445.
    Citations: 28     Fields:    Translation:AnimalsCells
  159. Pothoulakis C, Castagliuolo I, Kelly CP, Lamont JT. Clostridium difficile-associated diarrhea and colitis: pathogenesis and therapy. Int J Antimicrob Agents. 1993 Jul; 3(1):17-32. PMID: 18611542.
    Citations: 3     Fields:    
  160. Pothoulakis C, Kelly CP, Joshi MA, Gao N, O'Keane CJ, Castagliuolo I, Lamont JT. Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. Gastroenterology. 1993 Apr; 104(4):1108-15. PMID: 8462799.
    Citations: 42     Fields:    Translation:AnimalsCells
  161. Kelly CP, Pothoulakis C, Orellana J, LaMont JT. Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A-receptor binding. Gastroenterology. 1992 Jan; 102(1):35-40. PMID: 1309359.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  162. Kelly CP, Feighery CF, Gallagher RB, Gibney MJ, Weir DG. Mucosal and systemic IgA anti-gliadin antibody in celiac disease. Contrasting patterns of response in serum, saliva, and intestinal secretions. Dig Dis Sci. 1991 Jun; 36(6):743-51. PMID: 2032515.
    Citations: 10     Fields:    Translation:Humans
  163. Leung DY, Kelly CP, Boguniewicz M, Pothoulakis C, LaMont JT, Flores A. Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin. J Pediatr. 1991 Apr; 118(4 Pt 1):633-7. PMID: 1901084.
    Citations: 63     Fields:    Translation:HumansCells
  164. Kelly CP, Feighery CF, Gallagher RB, Weir DG. Diagnosis and treatment of gluten-sensitive enteropathy. Adv Intern Med. 1990; 35:341-63. PMID: 2405597.
    Citations: 5     Fields:    Translation:Humans
  165. Gallagher RB, Kelly CP, Neville S, Sheils O, Weir DG, Feighery CF. Complement activation within the coeliac small intestine is localised to Brunner's glands. Gut. 1989 Nov; 30(11):1568-73. PMID: 2599443.
    Citations: 5     Fields:    Translation:Humans
  166. Kelly CP, Johnston CF, Nolan N, Keeling PW, Weir DG. Necrolytic migratory erythema with elevated plasma enteroglucagon in celiac disease. Gastroenterology. 1989 May; 96(5 Pt 1):1350-3. PMID: 2703119.
    Citations: 3     Fields:    Translation:Humans
  167. Gallagher RB, Feighery C, Weir DG, Kelly CP, Whelan CA. Studies on the interaction between alpha-gliadin and HLA and T cell receptor molecules in coeliac disease. Clin Exp Immunol. 1988 Dec; 74(3):413-8. PMID: 3266119.
    Citations: 1     Fields:    Translation:HumansCells
  168. Nolan NP, Kelly CP, Humphreys JF, Cooney C, O'Connor R, Walsh TN, Weir DG, O'Briain DS. An epidemic of pseudomembranous colitis: importance of person to person spread. Gut. 1987 Nov; 28(11):1467-73. PMID: 3428672.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  169. Kelly CP, England RE, McDonald GS, Weir DG. Suloctidil hepatitis: a case presentation. Ir J Med Sci. 1987 Oct; 156(10):290-1. PMID: 2828270.
    Citations:    Fields:    Translation:Humans
  170. Kelly CP, O'Shea B, Kelly J, Feighery C, Weir DG. Atopy and childhood coeliac disease. Lancet. 1987 Jul 11; 2(8550):109. PMID: 2885566.
    Citations: 1     Fields:    Translation:Humans
  171. Kelly CP, O'Connor R, Weir DG. Pseudomembranous colitis and cefotaxime. Lancet. 1986 Jan 11; 1(8472):102-3. PMID: 2867303.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.