Harvard Catalyst Profiles

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Sareh Parangi, M.D.

Title
Institution
Department
Address
Fax

Mentoring
Development of a Clinically Relevant Orthotopic Model for Human Medullary Thyroid Cancer
Summer, 03/26/13 - 08/23/13

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA239193 (FERRONE, SOLDANO) Jun 1, 2019 - May 31, 2021
    NIH/NCI
    Adaptive immunotherapy of anaplastic thyroid cancer
    Role: Co-Principal Investigator
  2. R01CA149738 (PARANGI, SAREH) Jan 14, 2011 - Dec 31, 2015
    NIH/NCI
    The Role of BRAF Mutation in Thyroid Cancer Invasion
    Role: Principal Investigator
  3. K08CA088965 (PARANGI, SAREH) Aug 7, 2002 - Jul 31, 2007
    NIH/NCI
    Antiangiogenic therapy of pancreatic cancer
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Enumah S, Fingeret A, Parangi S, Dias-Santagata D, Sadow PM, Lubitz CC. BRAFV600E Mutation is Associated with an Increased Risk of Papillary Thyroid Cancer Recurrence. World J Surg. 2020 08; 44(8):2685-2691. PMID: 32347351.
    Citations:    
  2. Wachtel H, Roses RE, Kuo LE, Lindeman BM, Nehs MA, Tavakkoli A, Parangi S, Hodin RA, Fraker DL, James BC, Carr AA, Wang TS, Solórzano CC, Lubitz CC. Adrenalectomy for Secondary Malignancy: Patients, Outcomes, and Indications. Ann Surg. 2020 May 18. PMID: 32427760.
    Citations:    
  3. McKinley SK, Parangi S. Addressing Sexual Harassment in Surgical Training. Ann Surg. 2020 04; 271(4):614-615. PMID: 31850995.
    Citations:    
  4. Golingan H, Samuels SK, Camacho P, Dadhania DM, Pedraza-Taborda FE, Randolph G, Parangi S, Bimston DN, Harrell RM. MANAGEMENT OF HYPERPARATHYROIDISM IN KIDNEY TRANSPLANTATION CANDIDATES: A NEED FOR CONSENSUS. Endocr Pract. 2020 Mar; 26(3):299-304. PMID: 31682519.
    Citations:    
  5. Gartland RM, Bloom JP, Parangi S, Hodin R, DeRoo C, Stephen AE, Narra V, Lubitz CC, Mort E. A Long, Unnerving Road: Malpractice Claims Involving the Surgical Management of Thyroid and Parathyroid Disease. World J Surg. 2019 11; 43(11):2850-2855. PMID: 31384995.
    Citations:    
  6. Giantini Larsen AM, Pories S, Parangi S, Robertson FC. Barriers to Pursuing a Career in Surgery: An Institutional Survey of Harvard Medical School Students. Ann Surg. 2019 10 09. PMID: 31599803.
    Citations:    
  7. Shillcutt SK, Parangi S, Diekman S, Ghalib R, Schoenthaler R, Girgis LM, Parekh R, Bhargava H, Silver JK. Survey of Women Physicians' Experience with Elected Leadership Positions. Health Equity. 2019; 3(1):162-168. PMID: 31289775.
    Citations:    
  8. Silver JK, Ghalib R, Poorman JA, Al-Assi D, Parangi S, Bhargava H, Shillcutt SK. Analysis of Gender Equity in Leadership of Physician-Focused Medical Specialty Societies, 2008-2017. JAMA Intern Med. 2019 Mar 01; 179(3):433-435. PMID: 30615072.
    Citations:    Fields:    
  9. Pories SE, Turner PL, Greenberg CC, Babu MA, Parangi S. Leadership in American Surgery: Women are Rising to the Top. Ann Surg. 2019 02; 269(2):199-205. PMID: 30048312.
    Citations:    Fields:    
  10. Gunda V, Gigliotti B, Ashry T, Ndishabandi D, McCarthy M, Zhou Z, Amin S, Lee KE, Stork T, Wirth L, Freeman GJ, Alessandrini A, Parangi S. Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer. Int J Cancer. 2019 05 01; 144(9):2266-2278. PMID: 30515783.
    Citations:    Fields:    
  11. Boufraqech M, Patel D, Nilubol N, Powers A, King T, Shell J, Lack J, Zhang L, Gara SK, Gunda V, Klubo-Gwiezdzinska J, Kumar S, Fagin J, Knauf J, Parangi S, Venzon D, Quezado M, Kebebew E. Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness. Thyroid. 2019 01; 29(1):79-92. PMID: 30398411.
    Citations:    Fields:    
  12. Kuo LE, Parangi S, Cho NL. Diversity and inclusion in a surgical society: A longitudinal investigation. Surgery. 2019 04; 165(4):808-813. PMID: 30509749.
    Citations:    Fields:    
  13. Gunda V, Gigliotti B, Ndishabandi D, Ashry T, McCarthy M, Zhou Z, Amin S, Freeman GJ, Alessandrini A, Parangi S. Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer. Br J Cancer. 2018 11; 119(10):1223-1232. PMID: 30327563.
    Citations:    Fields:    
  14. Fitarelli-Kiehl M, Yu F, Ashtaputre R, Leong KW, Ladas I, Supplee J, Paweletz C, Mitra D, Schoenfeld JD, Parangi S, Makrigiorgos GM. Denaturation-Enhanced Droplet Digital PCR for Liquid Biopsies. Clin Chem. 2018 12; 64(12):1762-1771. PMID: 30274976.
    Citations:    Fields:    
  15. West MA, Hwang S, Maier RV, Ahuja N, Angelos P, Bass BL, Brasel KJ, Chen H, Davis KA, Eberlein TJ, Fong Y, Greenberg CC, Lillemoe KD, McCarthy MC, Michelassi F, Numann PJ, Parangi S, Reyes JD, Sanfey HA, Stain SC, Weigel RJ, Wren SM. Ensuring Equity, Diversity, and Inclusion in Academic Surgery: An American Surgical Association White Paper. Ann Surg. 2018 09; 268(3):403-407. PMID: 30004923.
    Citations:    Fields:    
  16. Gopal RK, Kübler K, Calvo SE, Polak P, Livitz D, Rosebrock D, Sadow PM, Campbell B, Donovan SE, Amin S, Gigliotti BJ, Grabarek Z, Hess JM, Stewart C, Braunstein LZ, Arndt PF, Mordecai S, Shih AR, Chaves F, Zhan T, Lubitz CC, Kim J, Iafrate AJ, Wirth L, Parangi S, Leshchiner I, Daniels GH, Mootha VK, Dias-Santagata D, Getz G, McFadden DG. Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma. Cancer Cell. 2018 08 13; 34(2):242-255.e5. PMID: 30107175.
    Citations: 1     Fields:    
  17. Rosenbaum MW, Gigliotti BJ, Pai SI, Parangi S, Wachtel H, Mino-Kenudson M, Gunda V, Faquin WC. PD-L1 and IDO1 Are Expressed in Poorly Differentiated Thyroid Carcinoma. Endocr Pathol. 2018 Mar; 29(1):59-67. PMID: 29372535.
    Citations: 1     Fields:    Translation:Humans
  18. Lubitz CC, Zhan T, Gunda V, Amin S, Gigliotti BJ, Fingeret AL, Holm TM, Wachtel H, Sadow PM, Wirth LJ, Sullivan RJ, Panka DJ, Parangi S. Circulating BRAFV600E Levels Correlate with Treatment in Patients with Thyroid Carcinoma. Thyroid. 2018 03; 28(3):328-339. PMID: 29378474.
    Citations:    Fields:    Translation:HumansAnimals
  19. Mainthia R, Wachtel H, Chen Y, Mort E, Parangi S, Sadow PM, Lubitz CC. Evaluating the projected surgical impact of reclassifying noninvasive encapsulated follicular variant of papillary thyroid cancer as noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Surgery. 2018 01; 163(1):60-65. PMID: 29146229.
    Citations: 2     Fields:    Translation:Humans
  20. Snyder SK, Angelos P, Carty SE, Doherty GM, Howe JR, Lee JA, Libutti SK, Miller BS, Parangi S, Patel KN, Sippel RC, Sturgeon C, Wang TS, Yip L, Zeiger MA. Injection of bulking agents for laryngoplasty. Surgery. 2018 01; 163(1):6-8. PMID: 29129367.
    Citations:    Fields:    Translation:Humans
  21. Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Cancer Discov. 2018 02; 8(2):216-233. PMID: 29101163.
    Citations: 4     Fields:    
  22. Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018 02; 8(2):196-215. PMID: 29101162.
    Citations: 4     Fields:    
  23. Chen Y, Deshpande V, Ferrone C, Blaszkowsky LS, Parangi S, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C. Primary lymph node gastrinoma: A single institution experience. Surgery. 2017 11; 162(5):1088-1094. PMID: 28705492.
    Citations: 1     Fields:    Translation:Humans
  24. Silver JK, Slocum CS, Bank AM, Bhatnagar S, Blauwet CA, Poorman JA, Villablanca A, Parangi S. Where Are the Women? The Underrepresentation of Women Physicians Among Recognition Award Recipients From Medical Specialty Societies. PM R. 2017 Aug; 9(8):804-815. PMID: 28606837.
    Citations: 3     Fields:    Translation:Humans
  25. Sanfey H, Crandall M, Shaughnessy E, Stein SL, Cochran A, Parangi S, Laronga C. Strategies for Identifying and Closing the Gender Salary Gap in Surgery. J Am Coll Surg. 2017 08; 225(2):333-338. PMID: 28400299.
    Citations:    Fields:    
  26. Gunda V, Sarosiek KA, Brauner E, Kim YS, Amin S, Zhou Z, Letai A, Parangi S. Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis. Cancer Lett. 2017 06 01; 395:1-10. PMID: 28259821.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  27. Lubitz CC, De Gregorio L, Fingeret AL, Economopoulos KP, Termezawi D, Hassan M, Parangi S, Stephen AE, Halpern EF, Donelan K, Swan JS. Measurement and Variation in Estimation of Quality of Life Effects of Patients Undergoing Treatment for Papillary Thyroid Carcinoma. Thyroid. 2017 02; 27(2):197-206. PMID: 27824301.
    Citations: 1     Fields:    Translation:Humans
  28. Pusztaszeri M, Rossi ED, Auger M, Baloch Z, Bishop J, Bongiovanni M, Chandra A, Cochand-Priollet B, Fadda G, Hirokawa M, Hong S, Kakudo K, Krane JF, Nayar R, Parangi S, Schmitt F, Faquin WC. The Bethesda System for Reporting Thyroid Cytopathology: Proposed Modifications and Updates for the Second Edition from an International Panel. Acta Cytol. 2016; 60(5):399-405. PMID: 27764825.
    Citations: 5     Fields:    Translation:Humans
  29. Pusztaszeri M, Rossi ED, Auger M, Baloch Z, Bishop J, Bongiovanni M, Chandra A, Cochand-Priollet B, Fadda G, Hirokawa M, Hong S, Kakudo K, Krane JF, Nayar R, Parangi S, Schmitt F, Faquin WC. The Bethesda System for Reporting Thyroid Cytopathology: proposed modifications and updates for the second edition from an international panel. J Am Soc Cytopathol. 2016 Sep - Oct; 5(5):245-251. PMID: 31042501.
    Citations:    
  30. Liu Y, Gunda V, Zhu X, Xu X, Wu J, Askhatova D, Farokhzad OC, Parangi S, Shi J. Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7750-5. PMID: 27342857.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  31. Brauner E, Gunda V, Vanden Borre P, Zurakowski D, Kim YS, Dennett KV, Amin S, Freeman GJ, Parangi S. Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer. Oncotarget. 2016 Mar 29; 7(13):17194-211. PMID: 26943572.
    Citations: 4     Fields:    Translation:HumansAnimals
  32. De Gregorio L, Lubitz CC, Hodin RA, Gaz RD, Parangi S, Phitayakorn R, Stephen AE. The Truth about Double Adenomas: Incidence, Localization, and Intraoperative Parathyroid Hormone. J Am Coll Surg. 2016 06; 222(6):1044-52. PMID: 27234627.
    Citations: 2     Fields:    Translation:Humans
  33. Lubitz CC, Parangi S, Holm TM, Bernasconi MJ, Schalck AP, Suh H, Economopoulos KP, Gunda V, Donovan SE, Sadow PM, Wirth LJ, Sullivan RJ, Panka DJ. Detection of Circulating BRAF(V600E) in Patients with Papillary Thyroid Carcinoma. J Mol Diagn. 2016 Jan; 18(1):100-8. PMID: 26631873.
    Citations: 3     Fields:    Translation:HumansCells
  34. Parangi S. Editorial: Translaryngeal vocal cord ultrasound: Ready for prime time. Surgery. 2016 Jan; 159(1):67-9. PMID: 26522697.
    Citations:    Fields:    Translation:Humans
  35. Varmeh S, Vanden Borre P, Gunda V, Brauner E, Holm T, Wang Y, Sadreyev RI, Parangi S. Genome-wide analysis of differentially expressed miRNA in PLX4720-resistant and parental human thyroid cancer cell lines. Surgery. 2016 Jan; 159(1):152-62. PMID: 26456124.
    Citations: 1     Fields:    Translation:HumansCells
  36. Economopoulos KP, Phitayakorn R, Lubitz CC, Sadow PM, Parangi S, Stephen AE, Hodin RA. Should specific patient clinical characteristics discourage adrenal surgeons from performing laparoscopic transperitoneal adrenalectomy? Surgery. 2016 Jan; 159(1):240-8. PMID: 26453136.
    Citations: 4     Fields:    Translation:Humans
  37. Brauner E, Holmes BJ, Krane JF, Nishino M, Zurakowski D, Hennessey JV, Faquin WC, Parangi S. Performance of the Afirma Gene Expression Classifier in Hürthle Cell Thyroid Nodules Differs from Other Indeterminate Thyroid Nodules. Thyroid. 2015 Jul; 25(7):789-96. PMID: 25962906.
    Citations: 12     Fields:    Translation:HumansCells
  38. Hazen EP, Sherry NA, Parangi S, Rabito CA, Sadow PM. Case records of the Massachusetts General Hospital. Case 10-2015. A 15-year-old girl with Graves’ disease and psychotic symptoms. N Engl J Med. 2015 Mar 26; 372(13):1250-8. PMID: 25806918.
    Citations:    Fields:    Translation:Humans
  39. Chen Y, Masiakos PT, Gaz RD, Hodin RA, Parangi S, Randolph GW, Sadow PM, Stephen AE. Pediatric thyroidectomy in a high volume thyroid surgery center: Risk factors for postoperative hypocalcemia. J Pediatr Surg. 2015 Aug; 50(8):1316-9. PMID: 25783304.
    Citations: 1     Fields:    Translation:Humans
  40. Vanden Borre P, Gunda V, McFadden DG, Sadow PM, Varmeh S, Bernasconi M, Parangi S. Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer. Oncotarget. 2014 Jun 30; 5(12):3996-4010. PMID: 24994118.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  41. Gunda V, Frederick DT, Bernasconi MJ, Wargo JA, Parangi S. A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression. Thyroid. 2014 Aug; 24(8):1241-50. PMID: 24811699.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  42. Parangi S, Suh H. The role of genetic markers in the evaluation and management of thyroid nodules. Surg Clin North Am. 2014 Jun; 94(3):515-28. PMID: 24857574.
    Citations: 1     Fields:    Translation:Humans
  43. Bernet V, Hupart KH, Parangi S, Woeber KA. AACE/ACE disease state commentary: molecular diagnostic testing of thyroid nodules with indeterminate cytopathology. Endocr Pract. 2014 Apr; 20(4):360-3. PMID: 24727662.
    Citations: 15     Fields:    Translation:Humans
  44. Gunda V, Bucur O, Varnau J, Vanden Borre P, Bernasconi MJ, Khosravi-Far R, Parangi S. Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways. Cell Death Dis. 2014 Mar 06; 5:e1104. PMID: 24603332.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  45. Vanden Borre P, McFadden DG, Gunda V, Sadow PM, Varmeh S, Bernasconi M, Jacks T, Parangi S. The next generation of orthotopic thyroid cancer models: immunocompetent orthotopic mouse models of BRAF V600E-positive papillary and anaplastic thyroid carcinoma. Thyroid. 2014 Apr; 24(4):705-14. PMID: 24295207.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  46. Gunda V, Cogdill AP, Bernasconi MJ, Wargo JA, Parangi S. Potential role of 5-aza-2'-deoxycytidine induced MAGE-A4 expression in immunotherapy for anaplastic thyroid cancer. Surgery. 2013 Dec; 154(6):1456-62; discussion 1462. PMID: 24238058.
    Citations: 5     Fields:    Translation:HumansCells
  47. Phitayakorn R, Morales-Garcia D, Wanderer J, Lubitz CC, Gaz RD, Stephen AE, Ehrenfeld JM, Daniels GH, Hodin RA, Parangi S. Surgery for Graves' disease: a 25-year perspective. Am J Surg. 2013 Nov; 206(5):669-73. PMID: 24011567.
    Citations: 4     Fields:    Translation:Humans
  48. Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2013 Mar 14; 121(11):2154-64. PMID: 23315169.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  49. Prescott JD, Sadow PM, Hodin RA, Le LP, Gaz RD, Randolph GW, Stephen AE, Parangi S, Daniels GH, Lubitz CC. BRAF V600E status adds incremental value to current risk classification systems in predicting papillary thyroid carcinoma recurrence. Surgery. 2012 Dec; 152(6):984-90. PMID: 23158172.
    Citations: 16     Fields:    Translation:Humans
  50. Nagarkatti SS, Faquin WC, Lubitz CC, Garcia DM, Barbesino G, Ross DS, Hodin RA, Daniels GH, Parangi S. Management of thyroid nodules with atypical cytology on fine-needle aspiration biopsy. Ann Surg Oncol. 2013 Jan; 20(1):60-5. PMID: 22941160.
    Citations: 8     Fields:    Translation:Humans
  51. Lubitz CC, Nagarkatti SS, Faquin WC, Samir AE, Hassan MC, Barbesino G, Ross DS, Randolph GW, Gaz RD, Stephen AE, Hodin RA, Daniels GH, Parangi S. Diagnostic yield of nondiagnostic thyroid nodules is not altered by timing of repeat biopsy. Thyroid. 2012 Jun; 22(6):590-4. PMID: 22667452.
    Citations: 10     Fields:    Translation:Humans
  52. Barbesino G, Goldfarb M, Parangi S, Yang J, Ross DS, Daniels GH. Thyroid lobe ablation with radioactive iodine as an alternative to completion thyroidectomy after hemithyroidectomy in patients with follicular thyroid carcinoma: long-term follow-up. Thyroid. 2012 Apr; 22(4):369-76. PMID: 22385290.
    Citations: 6     Fields:    Translation:Humans
  53. Samir AE, Vij A, Seale MK, Desai G, Halpern E, Faquin WC, Parangi S, Hahn PF, Daniels GH. Ultrasound-guided percutaneous thyroid nodule core biopsy: clinical utility in patients with prior nondiagnostic fine-needle aspirate. Thyroid. 2012 May; 22(5):461-7. PMID: 22304390.
    Citations: 30     Fields:    Translation:Humans
  54. Prescott JD, Parangi S. Bilaterality in papillary thyroid carcinoma: does it influence prognosis? Ann Surg Oncol. 2012 Jan; 19(1):1-2. PMID: 21956610.
    Citations: 3     Fields:    Translation:Humans
  55. Nehs MA, Nucera C, Nagarkatti SS, Sadow PM, Morales-Garcia D, Hodin RA, Parangi S. Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer. Endocrinology. 2012 Feb; 153(2):985-94. PMID: 22202162.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  56. Yip DT, Hassan M, Pazaitou-Panayiotou K, Ruan DT, Gawande AA, Gaz RD, Moore FD, Hodin RA, Stephen AE, Sadow PM, Daniels GH, Randolph GW, Parangi S, Lubitz CC. Preoperative basal calcitonin and tumor stage correlate with postoperative calcitonin normalization in patients undergoing initial surgical management of medullary thyroid carcinoma. Surgery. 2011 Dec; 150(6):1168-77. PMID: 22136837.
    Citations: 3     Fields:    Translation:Humans
  57. Goldfarb M, Perry Z, A Hodin R, Parangi S. Medical and surgical risks in thyroid surgery: lessons from the NSQIP. Ann Surg Oncol. 2011 Dec; 18(13):3551-8. PMID: 21769463.
    Citations: 5     Fields:    Translation:Humans
  58. Nucera C, Lawler J, Parangi S. BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res. 2011 Apr 01; 71(7):2417-22. PMID: 21447745.
    Citations: 33     Fields:    Translation:HumansAnimals
  59. Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist. 2011; 16(3):296-309. PMID: 21355020.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  60. Nagarkatti SS, Mekel M, Sofferman RA, Parangi S. Overcoming obstacles to setting up office-based ultrasound for evaluation of thyroid and parathyroid diseases. Laryngoscope. 2011 Mar; 121(3):548-54. PMID: 21305549.
    Citations: 1     Fields:    Translation:Humans
  61. Cabot RC, Harris NL, Shepard JA, Rosenberg ES, Cort AM, Ebeling SH, Peters CC, Misra M, Parangi S, Ross DS, Shailam R, Sadow PM. Case records of the Massachusetts General Hospital: Case 38-2010: a 13-year-old girl with an enlarging neck mass. N Engl J Med. 2010 Dec 16; 363(25):2445-54. PMID: 21158661.
    Citations: 2     Fields:    Translation:Humans
  62. Yip L, Kebebew E, Milas M, Carty SE, Fahey TJ, Parangi S, Zeiger MA, Nikiforov YE. Summary statement: utility of molecular marker testing in thyroid cancer. Surgery. 2010 Dec; 148(6):1313-5. PMID: 21134567.
    Citations: 8     Fields:    Translation:Humans
  63. Goldfarb M, Gondek S, Hodin R, Parangi S. Resident/fellow assistance in the operating room for endocrine surgery in the era of fellowships. Surgery. 2010 Dec; 148(6):1065-71; discussion 1071-2. PMID: 21134534.
    Citations: 2     Fields:    Translation:Humans
  64. Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? Oncotarget. 2010 Dec; 1(8):751-6. PMID: 21321384.
    Citations: 19     Fields:    Translation:Humans
  65. Lubitz CC, Hunter GJ, Hamberg LM, Parangi S, Ruan D, Gawande A, Gaz RD, Randolph GW, Moore FD, Hodin RA, Stephen AE. Accuracy of 4-dimensional computed tomography in poorly localized patients with primary hyperparathyroidism. Surgery. 2010 Dec; 148(6):1129-37; discussion 1137-8. PMID: 21134543.
    Citations: 6     Fields:    Translation:Humans
  66. Nehs MA, Nagarkatti S, Nucera C, Hodin RA, Parangi S. Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer. Surgery. 2010 Dec; 148(6):1154-62; discussion 1162. PMID: 21134546.
    Citations: 19     Fields:    Translation:Animals
  67. Mekel M, Nucera C, Hodin RA, Parangi S. Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules. Am J Surg. 2010 Jul; 200(1):136-43. PMID: 20637346.
    Citations: 2     Fields:    Translation:Humans
  68. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10649-54. PMID: 20498063.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  69. Mekel M, Stephen AE, Gaz RD, Randolph GW, Richer S, Perry ZH, Lubitz CC, Nehs MA, Parangi S, Hodin RA. Surgical drains can be safely avoided in lateral neck dissections for papillary thyroid cancer. Am J Surg. 2010 Apr; 199(4):485-90. PMID: 20359568.
    Citations: 2     Fields:    Translation:Humans
  70. Lubitz CC, Faquin WC, Yang J, Mekel M, Gaz RD, Parangi S, Randolph GW, Hodin RA, Stephen AE. Clinical and cytological features predictive of malignancy in thyroid follicular neoplasms. Thyroid. 2010 Jan; 20(1):25-31. PMID: 20025540.
    Citations: 15     Fields:    Translation:HumansCells
  71. Mekel M, Stephen AE, Gaz RD, Perry ZH, Hodin RA, Parangi S. Thyroid surgery in octogenarians is associated with higher complication rates. Surgery. 2009 Nov; 146(5):913-21. PMID: 19744461.
    Citations: 11     Fields:    Translation:Humans
  72. Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S. A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid. 2009 Oct; 19(10):1077-84. PMID: 19772429.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  73. O'Neal PB, Poylin V, Mowschenson P, Parangi S, Horowitz G, Pant P, Hasselgren PO. When initial postexcision PTH level does not fall appropriately during parathyroidectomy: what to do next? World J Surg. 2009 Aug; 33(8):1665-73. PMID: 19495864.
    Citations: 1     Fields:    Translation:Humans
  74. Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J. Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Oct; 23(10):3368-76. PMID: 19528255.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  75. Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Res. 2009 May 01; 69(9):3856-65. PMID: 19366809.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  76. Nucera C, Goldfarb M, Hodin R, Parangi S. Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E). Biochim Biophys Acta. 2009 Apr; 1795(2):152-61. PMID: 19356676.
    Citations: 25     Fields:    Translation:Humans
  77. Demirjian AN, Grossman JM, Chan JL, Parangi S. Parathyroid carcinoma and neurofibromatosis. Surgery. 2008 Nov; 144(5):827-9. PMID: 19081027.
    Citations:    Fields:    Translation:Humans
  78. Zhang X, Parangi S. Quantification of vascular endothelial cell apoptosis in vivo. Methods Enzymol. 2008; 446:287-92. PMID: 18603129.
    Citations:    Fields:    Translation:AnimalsCells
  79. Zhang X, Xu J, Lawler J, Terwilliger E, Parangi S. Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin. Clin Cancer Res. 2007 Jul 01; 13(13):3968-76. PMID: 17606731.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  80. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO. Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg. 2007 Jun; 193(6):707-12. PMID: 17512281.
    Citations: 3     Fields:    Translation:Humans
  81. Parangi S, Levine D, Henry A, Isakovich N, Pories S. Surgical gastrointestinal disorders during pregnancy. Am J Surg. 2007 Feb; 193(2):223-32. PMID: 17236852.
    Citations: 13     Fields:    Translation:Humans
  82. Evenson A, Mitchell J, Wei W, Poylin V, Parangi S, Hasselgren PO. The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases, atrogin-1 and MuRF1, are not altered in patients with primary hyperparathyroidism. Int J Mol Med. 2006 Sep; 18(3):471-5. PMID: 16865232.
    Citations:    Fields:    Translation:Humans
  83. Zhang X, Connolly C, Duquette M, Lawler J, Parangi S. Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. Cancer Lett. 2007 Mar 08; 247(1):143-9. PMID: 16757110.
    Citations: 8     Fields:    Translation:HumansAnimals
  84. Upalakalin JN, Collins LC, Tawa N, Parangi S. Carcinoid tumors in the breast. Am J Surg. 2006 Jun; 191(6):799-805. PMID: 16720153.
    Citations: 17     Fields:    Translation:Humans
  85. Kim MP, Vin Y, Parangi S. Image of the month. Enterolithotomy. Arch Surg. 2006 Jun; 141(6):609-10. PMID: 16785364.
    Citations:    Fields:    Translation:Humans
  86. Osborn C, Parangi S. Partial thyroidectomy: illustrated reflections for surgical residents. Curr Surg. 2006 Jan-Feb; 63(1):39-43. PMID: 16373159.
    Citations:    Fields:    Translation:Humans
  87. Warren AG, Parangi S. Image of the month: acute and chronic cholecystitis with abscess formation. Arch Surg. 2006 Jan; 141(1):101-2. PMID: 16415420.
    Citations:    Fields:    Translation:Humans
  88. Mitchell JC, Grant F, Evenson AR, Parker JA, Hasselgren PO, Parangi S. Preoperative evaluation of thyroid nodules with 18FDG-PET/CT. Surgery. 2005 Dec; 138(6):1166-74; discussion 1174-5. PMID: 16360405.
    Citations: 22     Fields:    Translation:Humans
  89. Zhang X, Galardi E, Duquette M, Lawler J, Parangi S. Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. Clin Cancer Res. 2005 Aug 01; 11(15):5622-30. PMID: 16061881.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  90. Mitchell JC, Parangi S. Angiogenesis in benign and malignant thyroid disease. Thyroid. 2005 Jun; 15(6):494-510. PMID: 16029116.
    Citations: 5     Fields:    Translation:HumansAnimals
  91. Ren B, Wang Y, Ndebele K, Zhi Q, Chen FH, Wang YZ, Parangi S. Multiple signaling is involved in endostatin-mediated apoptosis in ECV 304 endothelial cells. Front Biosci. 2005 May 01; 10:1089-97. PMID: 15769608.
    Citations: 4     Fields:    Translation:HumansCells
  92. Zhang X, Galardi E, Duquette M, Delic M, Lawler J, Parangi S. Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. Clin Cancer Res. 2005 Mar 15; 11(6):2337-44. PMID: 15788685.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  93. Mitchell J, Parangi S. The thyroid incidentaloma: an increasingly frequent consequence of radiologic imaging. Semin Ultrasound CT MR. 2005 Feb; 26(1):37-46. PMID: 15771264.
    Citations: 13     Fields:    Translation:Humans
  94. Mitchell JC, Parangi S. Thyroid incidentalomas: a new epidemic. Curr Surg. 2004 Nov-Dec; 61(6):545-51. PMID: 15590018.
    Citations: 3     Fields:    Translation:Humans
  95. Stephan S, Datta K, Wang E, Li J, Brekken RA, Parangi S, Thorpe PE, Mukhopadhyay D. Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. Clin Cancer Res. 2004 Oct 15; 10(20):6993-7000. PMID: 15501979.
    Citations: 25     Fields:    Translation:Animals
  96. Gremmels JM, Kruskal JB, Parangi S, Kane RA. Hemorrhagic cholecystitis simulating gallbladder carcinoma. J Ultrasound Med. 2004 Jul; 23(7):993-5. PMID: 15292572.
    Citations: 3     Fields:    Translation:Humans
  97. Silver RJ, Parangi S. Management of thyroid incidentalomas. Surg Clin North Am. 2004 Jun; 84(3):907-19. PMID: 15145242.
    Citations: 10     Fields:    Translation:Humans
  98. Mitchell JC, Parangi S. Laparoscopic adrenalectomy for pheochromocytoma. Curr Surg. 2003 Nov-Dec; 60(6):561-6. PMID: 14972190.
    Citations: 1     Fields:    
  99. Saurborn DP, Kruskal JB, Stillman IE, Parangi S. Best cases from the AFIP: paraganglioma of the organs of Zuckerkandl. Radiographics. 2003 Sep-Oct; 23(5):1279-86. PMID: 12975514.
    Citations: 5     Fields:    Translation:Humans
  100. Zeng H, Datta K, Neid M, Li J, Parangi S, Mukhopadhyay D. Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line. Biochem Biophys Res Commun. 2003 Feb 28; 302(1):46-55. PMID: 12593846.
    Citations: 19     Fields:    Translation:HumansCells
  101. D'Avanzo A, Parangi S, Morita E, Perrier ND, Wu HS, Siperstein AE, Duh QY, Treseler PA, Clark OH. False positive 99mTc sestamibi scans in patients with osteitis fibrosa cystica and brown tumours. Eur J Surg. 2001 Aug; 167(8):592-7. PMID: 11716445.
    Citations: 1     Fields:    Translation:Humans
  102. D'Avanzo A, Parangi S, Morita E, Duh QY, Siperstein AE, Clark OH. Hyperparathyroidism after thyroid surgery and autotransplantation of histologically normal parathyroid glands. J Am Coll Surg. 2000 May; 190(5):546-52. PMID: 10801021.
    Citations: 6     Fields:    Translation:Humans
  103. Evans CP, Elfman F, Parangi S, Conn M, Cunha G, Shuman MA. Inhibition of prostate cancer neovascularization and growth by urokinase-plasminogen activator receptor blockade. Cancer Res. 1997 Aug 15; 57(16):3594-9. PMID: 9270033.
    Citations: 9     Fields:    Translation:Animals
  104. Arbiser JL, Moses MA, Fernandez CA, Ghiso N, Cao Y, Klauber N, Frank D, Brownlee M, Flynn E, Parangi S, Byers HR, Folkman J. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):861-6. PMID: 9023347.
    Citations: 103     Fields:    Translation:AnimalsCells
  105. Klauber N, Parangi S, Flynn E, Hamel E, D'Amato RJ. Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res. 1997 Jan 01; 57(1):81-6. PMID: 8988045.
    Citations: 82     Fields:    Translation:HumansAnimals
  106. Parangi S, O'Reilly M, Christofori G, Holmgren L, Grosfeld J, Folkman J, Hanahan D. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):2002-7. PMID: 8700875.
    Citations: 58     Fields:    Translation:AnimalsCells
  107. Parangi S, Dietrich W, Christofori G, Lander ES, Hanahan D. Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma. Cancer Res. 1995 Dec 15; 55(24):6071-6. PMID: 8521395.
    Citations: 19     Fields:    Translation:Animals
  108. Chen C, Parangi S, Tolentino MJ, Folkman J. A strategy to discover circulating angiogenesis inhibitors generated by human tumors. Cancer Res. 1995 Oct 01; 55(19):4230-3. PMID: 7545537.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  109. Parangi S, Oz MC, Blume RS, Bixon R, Laffey KJ, Perzin KH, Buda JA, Markowitz AM, Nowygrod R. Hepatobiliary complications of polyarteritis nodosa. Arch Surg. 1991 Jul; 126(7):909-12. PMID: 1677243.
    Citations: 8     Fields:    Translation:Humans
  110. Oz MC, Johnson JP, Parangi S, Chuck RS, Marboe CC, Bass LS, Nowygrod R, Treat MR. Tissue soldering by use of indocyanine green dye-enhanced fibrinogen with the near infrared diode laser. J Vasc Surg. 1990 May; 11(5):718-25. PMID: 2335838.
    Citations: 6     Fields:    Translation:Animals
  111. Oz MC, Bass LS, Chuck RS, Johnson JP, Parangi S, Nowygrod R, Treat MR. Strength of laser vascular fusion: preliminary observations on the role of thrombus. Lasers Surg Med. 1990; 10(4):393-5. PMID: 2392020.
    Citations:    Fields:    Translation:Animals
  112. Wong SM, Lindeman RP, Parangi S, Chase HS. Role of calcium in mediating action of carbachol in T84 cells. Am J Physiol. 1989 Nov; 257(5 Pt 1):C976-85. PMID: 2556936.
    Citations: 11     Fields:    Translation:HumansCells
  113. Shea C, Glass DJ, Parangi S, Van der Ploeg LH. Variant surface glycoprotein gene expression site switches in Trypanosoma brucei. J Biol Chem. 1986 May 05; 261(13):6056-63. PMID: 3009443.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.