Harvard Catalyst Profiles

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Xiaoying Wang, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS099539 (WANG, XIAOYING) Aug 2, 2019 - Jun 30, 2021
    Recombinant FGF21 as a novel approach for treating ischemic stroke in type 2 diabetes
    Role: Principal Investigator
  2. R01NS092085 (WANG, XIAOYING) Aug 2, 2019 - Feb 29, 2020
    Annexin A2 as a cerebrovascular therapy in traumatic brain injury
    Role: Principal Investigator
  3. U01NS072324 (WANG, XIAOYING) Aug 15, 2011 - Jul 31, 2016
    Development of annexin A2 plus tPA as a novel stroke thrombolytic therapy
    Role: Principal Investigator
  4. R01NS065998 (WANG, XIAOYING) Jul 1, 2010 - Jun 30, 2015
    Recombinant annexin A2 plus tPA for combination stroke therapy
    Role: Principal Investigator
  5. R01NS049476 (WANG, XIAOYING) Jan 1, 2006 - Dec 31, 2010
    Neuroprotective Mechanisms of Neuroglobin in Stroke
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang Q, Yuan J, Yu Z, Lin L, Jiang Y, Cao Z, Zhuang P, Whalen MJ, Song B, Wang XJ, Li X, Lo EH, Xu Y, Wang X. FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice. Mol Neurobiol. 2018 Jun; 55(6):4702-4717. PMID: 28712011.
    Citations: 2     Fields:    
  2. Weng L, Cao X, Han L, Zhao H, Qiu S, Yan Y, Wang X, Chen X, Zheng W, Xu X, Gao Y, Chen Y, Li J, Yang Y, Xu Y. Association of increased Treg and Th17 with pathogenesis of moyamoya disease. Sci Rep. 2017 06 08; 7(1):3071. PMID: 28596558.
    Citations:    Fields:    Translation:HumansCells
  3. Fan X, Jiang Y, Yu Z, Liu Q, Guo S, Sun X, van Leyen K, Ning M, Gao X, Lo EH, Wang X. Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats. Transl Stroke Res. 2017 12; 8(6):549-559. PMID: 28580536.
    Citations: 2     Fields:    Translation:Animals
  4. Lin L, Desai R, Wang X, Lo EH, Xing C. Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation. 2017 05 08; 14(1):101. PMID: 28482909.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Lin L, Wang Q, Qian K, Cao Z, Xiao J, Wang X, Li X, Yu Z. bFGF Protects Against Oxygen Glucose Deprivation/Reoxygenation-Induced Endothelial Monolayer Permeability via S1PR1-Dependent Mechanisms. Mol Neurobiol. 2018 Apr; 55(4):3131-3142. PMID: 28466272.
    Citations:    Fields:    
  6. Ji B, Zhou F, Han L, Yang J, Fan H, Li S, Li J, Zhang X, Wang X, Chen X, Xu Y. Sodium Tanshinone IIA Sulfonate Enhances Effectiveness Rt-PA Treatment in Acute Ischemic Stroke Patients Associated with Ameliorating Blood-Brain Barrier Damage. Transl Stroke Res. 2017 08; 8(4):334-340. PMID: 28243834.
    Citations: 3     Fields:    Translation:Humans
  7. Liu Y, Zheng Y, Karatas H, Wang X, Foerch C, Lo EH, van Leyen K. 12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke. Stroke. 2017 02; 48(2):445-451. PMID: 28057806.
    Citations: 2     Fields:    Translation:Animals
  8. Zhao S, Yu Z, Liu Y, Bai Y, Jiang Y, van Leyen K, Yang YG, Lok JM, Whalen MJ, Lo EH, Wang X. CD47 deficiency improves neurological outcomes of traumatic brain injury in mice. Neurosci Lett. 2017 03 16; 643:125-130. PMID: 27931776.
    Citations:    Fields:    Translation:Animals
  9. Takase H, Washida K, Hayakawa K, Arai K, Wang X, Lo EH, Lok J. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2018 03 15; 340:205-211. PMID: 27829126.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  11. Liu N, Yu Z, Xun Y, Li M, Peng X, Xiao Y, Hu X, Sun Y, Yang M, Gan S, Yuan S, Wang X, Xiang S, Zhang J. TNFAIP1 contributes to the neurotoxicity induced by Aß25-35 in Neuro2a cells. BMC Neurosci. 2016 07 18; 17(1):51. PMID: 27430312.
    Citations:    Fields:    Translation:AnimalsCells
  12. Yang M, Orgah J, Zhu J, Fan G, Han J, Wang X, Zhang B, Zhu Y. Danhong injection attenuates cardiac injury induced by ischemic and reperfused neuronal cells through regulating arginine vasopressin expression and secretion. Brain Res. 2016 07 01; 1642:516-523. PMID: 27107944.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Yuan J, Cui G, Li W, Zhang X, Wang X, Zheng H, Zhang J, Xiang S, Xie Z. Propofol Enhances Hemoglobin-Induced Cytotoxicity in Neurons. Anesth Analg. 2016 Apr; 122(4):1024-30. PMID: 26771264.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH. Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma. 2016 07 15; 33(14):1303-16. PMID: 26528928.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Liu N, Yu Z, Gao X, Song YS, Yuan J, Xun Y, Wang T, Yan F, Yuan S, Zhang J, Xiang S, Lo EH, Wang X. Establishment of Cell-Based Neuroglobin Promoter Reporter Assay for Neuroprotective Compounds Screening. CNS Neurol Disord Drug Targets. 2016; 15(5):629-39. PMID: 26996171.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS. Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. J Neurochem. 2016 Feb; 136(4):851-858. PMID: 26603372.
    Citations: 3     Fields:    
  17. Jiang Y, Fan X, Yu Z, Liao Z, Wang XS, van Leyen K, Sun X, Lo EH, Wang X. Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy. Front Cell Neurosci. 2015; 9:397. PMID: 26528130.
    Citations: 3     
  18. van Leyen K, Arai K, Wang X, Lo EH. From cell to cell: the breakdown of intercellular connectivity after stroke and how to regain contact. Brain Res. 2015 Oct 14; 1623:1-2. PMID: 26363519.
    Citations: 1     Fields:    Translation:Humans
  19. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X. Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res. 2015 Dec; 6(6):478-84. PMID: 26449616.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Jiang Y, Fan X, Yu Z, Cheng C, Wang XS, Lo EH, Sun X, Wang X. Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment-associated hemorrhage and improves recovery in rat embolic focal stroke. Neurosci Lett. 2015 Aug 18; 602:73-8. PMID: 26149229.
    Citations: 5     Fields:    Translation:Animals
  21. Yu Z, Zhang Y, Liu N, Yuan J, Lin L, Zhuge Q, Xiao J, Wang X. Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons. Mol Neurobiol. 2016 07; 53(5):3249-3257. PMID: 26050086.
    Citations: 9     Fields:    Translation:AnimalsCells
  22. Yu Z, Li Z, Liu N, Jizhang Y, McCarthy TJ, Tedford CE, Lo EH, Wang X. Near infrared radiation protects against oxygen-glucose deprivation-induced neurotoxicity by down-regulating neuronal nitric oxide synthase (nNOS) activity in vitro. Metab Brain Dis. 2015 Jun; 30(3):829-37. PMID: 25796222.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Suh JY, Shim WH, Cho G, Fan X, Kwon SJ, Kim JK, Dai G, Wang X, Kim YR. Reduced microvascular volume and hemispherically deficient vasoreactivity to hypercapnia in acute ischemia: MRI study using permanent middle cerebral artery occlusion rat model. J Cereb Blood Flow Metab. 2015 Jun; 35(6):1033-43. PMID: 25690471.
    Citations: 3     Fields:    Translation:Animals
  24. Guo Z, Xu L, Wang X, Sun X. MMP-9 expression and activity is concurrent with endothelial cell apoptosis in the basilar artery after subarachnoid hemorrhaging in rats. Neurol Sci. 2015 Jul; 36(7):1241-5. PMID: 25627354.
    Citations:    Fields:    Translation:AnimalsCells
  25. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8. PMID: 25475543.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  26. Fan X, Jiang Y, Yu Z, Yuan J, Sun X, Xiang S, Lo EH, Wang X. Combination approaches to attenuate hemorrhagic transformation after tPA thrombolytic therapy in patients with poststroke hyperglycemia/diabetes. Adv Pharmacol. 2014; 71:391-410. PMID: 25307224.
    Citations: 6     Fields:    Translation:HumansAnimals
  27. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014 Jul; 45(7):2085-92. PMID: 24916903.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  28. Yu Z, Liu N, Zhao J, Li Y, McCarthy TJ, Tedford CE, Lo EH, Wang X. Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation. Metab Brain Dis. 2015 Apr; 30(2):491-6. PMID: 24599760.
    Citations: 4     Fields:    Translation:AnimalsCells
  29. Wang X, Fan X, Yu Z, Liao Z, Zhao J, Mandeville E, Guo S, Lo EH, Wang X. Effects of tissue plasminogen activator and annexin A2 combination therapy on long-term neurological outcomes of rat focal embolic stroke. Stroke. 2014 Feb; 45(2):619-22. PMID: 24368559.
    Citations: 9     Fields:    Translation:Animals
  30. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH. Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest. 2013 Aug; 123(8):3373-7. PMID: 23867621.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  31. Ning MM, Lopez M, Sarracino D, Cao J, Karchin M, McMullin D, Wang X, Buonanno FS, Lo EH. Pharmaco-proteomics opportunities for individualizing neurovascular treatment. Neurol Res. 2013 Jun; 35(5):448-56. PMID: 23711324.
    Citations: 4     Fields:    Translation:Humans
  32. Yu Z, Liu N, Li Y, Xu J, Wang X. Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons. Neurobiol Dis. 2013 Aug; 56:95-103. PMID: 23639789.
    Citations: 20     Fields:    Translation:AnimalsCells
  33. Yu Z, Poppe JL, Wang X. Mitochondrial mechanisms of neuroglobin's neuroprotection. Oxid Med Cell Longev. 2013; 2013:756989. PMID: 23634236.
    Citations: 13     Fields:    Translation:HumansCells
  34. Dai H, Yu Z, Fan X, Liu N, Yan M, Chen Z, Lo EH, Hajjar KA, Wang X. Dysfunction of annexin A2 contributes to hyperglycaemia-induced loss of human endothelial cell surface fibrinolytic activity. Thromb Haemost. 2013 Jun; 109(6):1070-8. PMID: 23572070.
    Citations: 4     Fields:    Translation:HumansCells
  35. Meng R, Wang X, Hussain M, Dornbos D, Meng L, Liu Y, Wu Y, Ning M, Ferdinando S B, Lo EH, Ding Y, Ji X. Evaluation of plasma D-dimer plus fibrinogen in predicting acute CVST. Int J Stroke. 2014 Feb; 9(2):166-73. PMID: 23506130.
    Citations: 5     Fields:    Translation:Humans
  36. Fan X, Lo EH, Wang X. Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats. Stroke. 2013 Mar; 44(3):745-52. PMID: 23422086.
    Citations: 26     Fields:    Translation:Animals
  37. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203. PMID: 23408937.
    Citations: 3     Fields:    Translation:Animals
  38. Rosell A, Agin V, Rahman M, Morancho A, Ali C, Koistinaho J, Wang X, Vivien D, Schwaninger M, Montaner J. Translational Stroke Research. Distal occlusion of the middle cerebral artery in mice: Are we ready to assess long-term functional outcome?. 2013; DOI 10.1007/s12975-012-0234-1.
  39. Liu N, Yu Z, Li Y, Yuan J, Zhang J, Xiang S, Wang X. Transcriptional regulation of mouse neuroglobin gene by cyclic AMP responsive element binding protein (CREB) in N2a cells. Neurosci Lett. 2013 Feb 08; 534:333-7. PMID: 23182882.
    Citations: 9     Fields:    Translation:AnimalsCells
  40. Fan X, Ning M, Lo EH, Wang X. Early insulin glycemic control combined with tPA thrombolysis reduces acute brain tissue damages in a focal embolic stroke model of diabetic rats. Stroke. 2013 Jan; 44(1):255-9. PMID: 23117722.
    Citations: 9     Fields:    Translation:HumansAnimalsPHPublic Health
  41. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, Li G, Ren C, Luo Y, Ling F, Jia J, Hua Y, Wang X, Ding Y, Lo EH, Ji X. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012 Oct 30; 79(18):1853-61. PMID: 23035060.
    Citations: 72     Fields:    Translation:HumansPHPublic Health
  42. Tjärnlund-Wolf A, Brogren H, Lo EH, Wang X. Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases. Stroke. 2012 Oct; 43(10):2833-9. PMID: 22879095.
    Citations: 13     Fields:    Translation:Humans
  43. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519.
    Citations: 11     Fields:    Translation:Animals
  44. Yu Z, Liu N, Liu J, Yang K, Wang X. Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders. Int J Mol Sci. 2012; 13(6):6995-7014. PMID: 22837676.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  45. Meng R, Dornbos D, Meng L, Wu Y, Liu Y, Li G, Li G, Li S, Sun F, Wang X, Ding Y, Ji X. Clinical differences between acute CVST and non-thrombotic CVSS. Clin Neurol Neurosurg. 2012 Nov; 114(9):1257-62. PMID: 22676956.
    Citations: 1     Fields:    Translation:Humans
  46. Yu Z, Xu J, Liu N, Wang Y, Li X, Pallast S, van Leyen K, Wang X. Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons. Neuroscience. 2012 Aug 30; 218:235-42. PMID: 22659017.
    Citations: 15     Fields:    Translation:AnimalsCells
  47. Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, Whalen MJ, Lo EH. Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury. Transl Stroke Res. 2012 Jul; 3 Suppl 1:S119-24. PMID: 22773936.
    Citations: 17     Fields:    
  48. Meng R, Yan W, Wang X, Dornbos D, Liu Y, Ning M, Ferdinando S B, Ding Y, Ji X. CVST, distinguished from nonthrombotic CVSS before treatment - a MUST. Int J Stroke. 2012 Apr; 7(3):274. PMID: 22405281.
    Citations:    Fields:    Translation:Humans
  49. Liu N, Yu Z, Xiang S, Zhao S, Tjärnlund-Wolf A, Xing C, Zhang J, Wang X. Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J. 2012 Apr 01; 443(1):153-64. PMID: 22239089.
    Citations: 14     Fields:    Translation:AnimalsCells
  50. Meng R, Konakondla S, Wang X, Lo EH, Ding Y, Ji X. Plasma biomarker may help to distinguish acute CVST from non-thrombotic CVSS in emergency. Int J Stroke. 2012 Feb; 7(2):183-4. PMID: 22264373.
    Citations:    Fields:    Translation:Humans
  51. Meng R, Ji X, Wang X, Ding Y. Intractable & Rare Diseases Research. The etiologies of new cases of cerebral venous sinus thrombosis reported in the past year. 2012; 1:23-26.
  52. Meng R, Ji X, Dornbos D, Feeney K, Ding Y, Wang X. A case of Susac's syndrome in a Chinese male. J Neurol Sci. 2012 Mar 15; 314(1-2):181-2; author reply 183. PMID: 22178082.
    Citations: 2     Fields:    Translation:Humans
  53. Yu Z, Liu N, Wang Y, Li X, Wang X. Identification of neuroglobin-interacting proteins using yeast two-hybrid screening. Neuroscience. 2012 Jan 03; 200:99-105. PMID: 22079573.
    Citations: 14     Fields:    Translation:AnimalsCells
  54. Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, Wang X. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012 Feb; 43(2):567-70. PMID: 22052516.
    Citations: 28     Fields:    Translation:Animals
  55. Wei X, Yu Z, Cho KS, Chen H, Malik MT, Chen X, Lo EH, Wang X, Chen DF. Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage. Am J Pathol. 2011 Dec; 179(6):2788-97. PMID: 21967817.
    Citations: 12     Fields:    Translation:AnimalsCells
  56. Lok J, Leung W, Zhao S, Pallast S, van Leyen K, Guo S, Wang X, Yalcin A, Lo EH. ?-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma. J Neurochem. 2011 Jul; 118(2):248-55. PMID: 21534958.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  57. Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH. Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain. Diabetes. 2011 Jun; 60(6):1789-96. PMID: 21562076.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  58. Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011 May; 42(5):1469-72. PMID: 21415401.
    Citations: 4     Fields:    Translation:Animals
  59. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5. PMID: 21372305.
    Citations: 10     Fields:    Translation:Animals
  60. Meng R, Li ZY, Ji X, Ding Y, Meng S, Wang X. Antithrombin III associated with fibrinogen predicts the risk of cerebral ischemic stroke. Clin Neurol Neurosurg. 2011 Jun; 113(5):380-6. PMID: 21316837.
    Citations: 5     Fields:    Translation:Humans
  61. Cheung JS, Wang X, Sun PZ . The Open Neuroimaging Journal. Magnetic resonance imaging and spectroscopy characterization of tissue metabolism impairment during acute ischemic stroke. 2011; 5(S 1-M2):66-73.
  62. Ning M, Sarracino DA, Kho AT, Guo S, Lee SR, Krastins B, Buonanno FS, Vizcaíno JA, Orchard S, McMullin D, Wang X, Lo EH. Proteomic temporal profile of human brain endothelium after oxidative stress. Stroke. 2011 Jan; 42(1):37-43. PMID: 21164131.
    Citations: 11     Fields:    Translation:HumansCells
  63. Ning M, Sarracino DA, Buonanno FS, Krastins B, Chou S, McMullin D, Wang X, Lopez M, Lo EH. Proteomic Protease Substrate Profiling of tPA Treatment in Acute Ischemic Stroke Patients: A Step Toward Individualizing Thrombolytic Therapy at the Bedside. Transl Stroke Res. 2010 Dec 01; 1(4):268-75. PMID: 22140417.
    Citations: 11     Fields:    
  64. Fan X, Yu Z, Liu J, Liu N, Hajjar KA, Furie KL, Lo EH, Wang X. Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy. Stroke. 2010 Oct; 41(10 Suppl):S54-8. PMID: 20876506.
    Citations: 15     Fields:    Translation:Animals
  65. Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, Zhao S, Hajjar KA, Lo EH, Wang X. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1137-46. PMID: 20068577.
    Citations: 40     Fields:    Translation:HumansAnimals
  66. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67. PMID: 20068575.
    Citations: 26     Fields:    Translation:AnimalsCells
  67. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41. PMID: 19469687.
    Citations: 35     Fields:    Translation:AnimalsCells
  68. Pallast S, Arai K, Wang X, Lo EH, van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9. PMID: 19737346.
    Citations: 33     Fields:    Translation:AnimalsCells
  69. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH. Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res. 2009 Aug 15; 87(11):2571-7. PMID: 19360900.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  70. Ji RR, Xu ZZ, Wang X, Lo EH. Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci. 2009 Jul; 30(7):336-40. PMID: 19523695.
    Citations: 30     Fields:    Translation:HumansAnimals
  71. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X. Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience. 2009 Aug 18; 162(2):396-403. PMID: 19401220.
    Citations: 27     Fields:    Translation:AnimalsCells
  72. Yu Z, Fan X, Lo EH, Wang X. Neuroprotective roles and mechanisms of neuroglobin. Neurol Res. 2009 Mar; 31(2):122-7. PMID: 19298751.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  73. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH. CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol. 2009 May; 217(1):165-70. PMID: 19233173.
    Citations: 27     Fields:    Translation:Animals
  74. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009 Jan; 87(1):164-70. PMID: 18711728.
    Citations: 42     Fields:    Translation:AnimalsCells
  75. Ning M, Wang X, Lo EH. Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier. Handb Clin Neurol. 2009; 92:117-36. PMID: 18790272.
    Citations: 5     Fields:    Translation:HumansAnimals
  76. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH. Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem. 2009 Jan; 108(2):430-6. PMID: 19012741.
    Citations: 18     Fields:    Translation:AnimalsCells
  77. Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH. Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke. 2008 Dec; 39(12):3372-7. PMID: 18927459.
    Citations: 80     Fields:    Translation:Animals
  78. Wang X, Rosell A, Lo EH. Targeting extracellular matrix proteolysis for hemorrhagic complications of tPA stroke therapy. CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):235-42. PMID: 18673208.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  79. Guo S, Kim WJ, Lok J, Lee SR, Besancon E, Luo BH, Stins MF, Wang X, Dedhar S, Lo EH. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7582-7. PMID: 18495934.
    Citations: 86     Fields:    Translation:AnimalsCells
  80. Sun PZ, Murata Y, Lu J, Wang X, Lo EH, Sorensen AG. Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke. Magn Reson Med. 2008 May; 59(5):1175-82. PMID: 18429031.
    Citations: 33     Fields:    Translation:Animals
  81. Wang X, Liu J, Zhu H, Tejima E, Tsuji K, Murata Y, Atochin DN, Huang PL, Zhang C, Lo EH. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke. 2008 Jun; 39(6):1869-74. PMID: 18403737.
    Citations: 59     Fields:    Translation:AnimalsCells
  82. Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH, Gao YJ, Roy K, Corfas G, Lo EH, Ji RR. Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med. 2008 Mar; 14(3):331-6. PMID: 18264108.
    Citations: 188     Fields:    Translation:AnimalsCells
  83. Lee SR, Lok J, Rosell A, Kim HY, Murata Y, Atochin D, Huang PL, Wang X, Ayata C, Moskowitz MA, Lo EH. Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience. 2007 Nov 30; 150(1):50-7. PMID: 17936515.
    Citations: 12     Fields:    Translation:AnimalsCells
  84. Ide K, Wang H, Tahara H, Liu J, Wang X, Asahara T, Sykes M, Yang YG, Ohdan H. Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5062-6. PMID: 17360380.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  85. Lee SR, Guo SZ, Scannevin RH, Magliaro BC, Rhodes KJ, Wang X, Lo EH. Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators. Neurosci Lett. 2007 Apr 24; 417(1):1-5. PMID: 17386975.
    Citations: 23     Fields:    Translation:AnimalsCells
  86. Tejima E, Zhao BQ, Tsuji K, Rosell A, van Leyen K, Gonzalez RG, Montaner J, Wang X, Lo EH. Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage. J Cereb Blood Flow Metab. 2007 Mar; 27(3):460-8. PMID: 16788715.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  87. Wang S, Lee SR, Guo SZ, Kim WJ, Montaner J, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes. Stroke. 2006 Jul; 37(7):1910-2. PMID: 16741180.
    Citations: 19     Fields:    Translation:AnimalsCells
  88. Ning M, Furie KL, Koroshetz WJ, Lee H, Barron M, Lederer M, Wang X, Zhu M, Sorensen AG, Lo EH, Kelly PJ. Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke. Neurology. 2006 May 23; 66(10):1550-5. PMID: 16717217.
    Citations: 54     Fields:    Translation:Humans
  89. Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006 Apr; 12(4):441-5. PMID: 16565723.
    Citations: 247     Fields:    Translation:AnimalsCells
  90. Shang A, Zhou D, Wang L, Gao Y, Fan M, Wang X, Zhou R, Zhang C. Increased neuroglobin levels in the cerebral cortex and serum after ischemia-reperfusion insults. Brain Res. 2006 Mar 17; 1078(1):219-26. PMID: 16492379.
    Citations: 23     Fields:    Translation:AnimalsCells
  91. Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005 Sep; 36(9):1954-9. PMID: 16051896.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  92. Lee SR, Wang X, Tsuji K, Lo EH. Extracellular proteolytic pathophysiology in the neurovascular unit after stroke. Neurol Res. 2004 Dec; 26(8):854-61. PMID: 15727269.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  93. Wang X, Tsuji K, Lee SR, Ning M, Furie KL, Buchan AM, Lo EH. Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke. 2004 Nov; 35(11 Suppl 1):2726-30. PMID: 15459442.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  94. Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H, Wang X, Rosenberg GA, Lo EH, Moskowitz MA. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest. 2004 May; 113(10):1447-55. PMID: 15146242.
    Citations: 113     Fields:    Translation:AnimalsCells
  95. Wang X, Lo EH. Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol. 2003 Dec; 28(3):229-44. PMID: 14709787.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  96. Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, Lo EH. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003 Oct; 9(10):1313-7. PMID: 12960961.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  97. Asahi M, Rammohan R, Sumii T, Wang X, Pauw RJ, Weissig V, Torchilin VP, Lo EH. Antiactin-targeted immunoliposomes ameliorate tissue plasminogen activator-induced hemorrhage after focal embolic stroke. J Cereb Blood Flow Metab. 2003 Aug; 23(8):895-9. PMID: 12902833.
    Citations: 6     Fields:    Translation:Animals
  98. Aoki T, Sumii T, Mori T, Wang X, Lo EH. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke. 2002 Nov; 33(11):2711-7. PMID: 12411666.
    Citations: 66     Fields:    Translation:AnimalsCells
  99. Mori T, Wang X, Aoki T, Lo EH. Downregulation of matrix metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain injury. J Neurotrauma. 2002 Nov; 19(11):1411-9. PMID: 12490006.
    Citations: 28     Fields:    Translation:AnimalsCells
  100. Ge Y, Wang X, Chen Z, Landman N, Lo EH, Kang JX. Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis. J Neurochem. 2002 Sep; 82(6):1360-6. PMID: 12354283.
    Citations: 9     Fields:    Translation:AnimalsCells
  101. Lo EH, Wang X, Cuzner ML. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res. 2002 Jul 01; 69(1):1-9. PMID: 12111810.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  102. Wang X, Mori T, Sumii T, Lo EH. Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke. 2002 Jul; 33(7):1882-8. PMID: 12105370.
    Citations: 58     Fields:    Translation:AnimalsCells
  103. Singhal AB, Wang X, Sumii T, Mori T, Lo EH. Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 2002 Jul; 22(7):861-8. PMID: 12142571.
    Citations: 46     Fields:    Translation:AnimalsCells
  104. Wang X, Mori T, Jung JC, Fini ME, Lo EH. Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J Neurotrauma. 2002 May; 19(5):615-25. PMID: 12042096.
    Citations: 28     Fields:    Translation:AnimalsCells
  105. Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52. PMID: 11919515.
    Citations: 39     Fields:    Translation:AnimalsCells
  106. Mori T, Wang X, Kline AE, Siao CJ, Dixon CE, Tsirka SE, Lo EH. Reduced cortical injury and edema in tissue plasminogen activator knockout mice after brain trauma. Neuroreport. 2001 Dec 21; 12(18):4117-20. PMID: 11742249.
    Citations: 14     Fields:    Translation:AnimalsCells
  107. Wang X, Shimizu-Sasamata M, Moskowitz MA, Newcomb R, Lo EH. Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice. Neurosci Lett. 2001 Nov 09; 313(3):121-4. PMID: 11682142.
    Citations: 3     Fields:    Translation:Animals
  108. Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 01; 21(19):7724-32. PMID: 11567062.
    Citations: 266     Fields:    Translation:AnimalsCells
  109. Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000 Sep 15; 20(18):7037-42. PMID: 10995849.
    Citations: 102     Fields:    Translation:AnimalsCells
  110. Asahi M, Asahi K, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Mar; 20(3):452-7. PMID: 10724108.
    Citations: 50     Fields:    Translation:Animals
  111. Matsushita K, Meng W, Wang X, Asahi M, Asahi K, Moskowitz MA, Lo EH. Evidence for apoptosis after intercerebral hemorrhage in rat striatum. J Cereb Blood Flow Metab. 2000 Feb; 20(2):396-404. PMID: 10698078.
    Citations: 68     Fields:    Translation:AnimalsCells
  112. Meng W, Wang X, Asahi M, Kano T, Asahi K, Ackerman RH, Lo EH. Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1999 Dec; 19(12):1316-21. PMID: 10598935.
    Citations: 17     Fields:    Translation:Animals
  113. Wang X, Asahi M, Lo EH. Tissue type plasminogen activator amplifies hemoglobin-induced neurotoxicity in rat neuronal cultures. Neurosci Lett. 1999 Oct 22; 274(2):79-82. PMID: 10553942.
    Citations: 12     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.