Harvard Catalyst Profiles

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Qi Cui Ott, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hastie MJ, Jalbout T, Ott Q, Hopf HW, Cevasco M, Hastie J. Disruptive Behavior in Medicine: Sources, Impact, and Management. Anesth Analg. 2020 12; 131(6):1943-1949. PMID: 33009135.
    Citations:    Fields:    Translation:Humans
  2. Pendleton AA, McKinley SK, Pendleton VE, Ott QC, Petrusa ER, Srivastava SD, Lillemoe KD, Ferrone CR. A multi-institutional study of patient-derived gender-based discrimination experienced by resident physicians. Am J Surg. 2021 02; 221(2):309-314. PMID: 33081931.
    Citations:    Fields:    Translation:Humans
  3. Mitchell JD, Ku C, Wong V, Fisher LJ, Muret-Wagstaff SL, Ott Q, Shahul S, Bose R, Tibbles C, Jones SB. The Impact of a Resident Communication Skills Curriculum on Patients' Experiences of Care. A A Case Rep. 2016 Feb 01; 6(3):65-75. PMID: 26669651.
    Citations: 2     Fields:    Translation:Humans
  4. Chen D, Banerjee S, Cui QC, Kong D, Sarkar FH, Dou QP. Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo. PLoS One. 2012; 7(10):e47186. PMID: 23056607.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  5. Kona FR, Stark K, Bisoski L, Buac D, Cui Q, Dou QP. Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor. Breast Cancer Res Treat. 2012 Sep; 135(2):495-503. PMID: 22850893.
    Citations: 8     Fields:    Translation:HumansCells
  6. Wang S, Cui GZ, Song XF, Feng Y, Cui Q. Efficiency and stability enhancement of cis-epoxysuccinic acid hydrolase by fusion with a carbohydrate binding module and immobilization onto cellulose. Appl Biochem Biotechnol. 2012 Oct; 168(3):708-17. PMID: 22843080.
    Citations: 2     Fields:    Translation:Cells
  7. Cui GZ, Wang S, Li Y, Tian YJ, Feng Y, Cui Q. High yield recombinant expression, characterization and homology modeling of two types of cis-epoxysuccinic acid hydrolases. Protein J. 2012 Jun; 31(5):432-8. PMID: 22592448.
    Citations: 1     Fields:    Translation:Cells
  8. Neslund-Dudas C, Mitra B, Kandegedara A, Chen D, Schmitt S, Shen M, Cui Q, Rybicki BA, Dou QP. Association of metals and proteasome activity in erythrocytes of prostate cancer patients and controls. Biol Trace Elem Res. 2012 Oct; 149(1):5-9. PMID: 22422614.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  9. Cui GZ, Hong W, Zhang J, Li WL, Feng Y, Liu YJ, Cui Q. Targeted gene engineering in Clostridium cellulolyticum H10 without methylation. J Microbiol Methods. 2012 Jun; 89(3):201-8. PMID: 22450138.
    Citations: 18     Fields:    Translation:Cells
  10. Chen D, Pamu S, Cui Q, Chan TH, Dou QP. Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells. Bioorg Med Chem. 2012 May 01; 20(9):3031-7. PMID: 22459208.
    Citations: 35     Fields:    Translation:HumansCells
  11. Liu J, Tang Y, Wu K, Bi C, Cui Q. Conversion of fructose into 5-hydroxymethylfurfural (HMF) and its derivatives promoted by inorganic salt in alcohol. Carbohydr Res. 2012 Mar 01; 350:20-4. PMID: 22264628.
    Citations: 3     Fields:    Translation:Cells
  12. Cui Q, Li D, Zhang J, Wang X, Liu S, Wang L, Zhang P, Zhou J, Liu C, Jiang W, Zeng Y. The significance of preoperative chemotherapy in evaluation of recurrent soft tissue liposarcoma necrosis. Pathol Oncol Res. 2012 Jul; 18(3):629-33. PMID: 22173612.
    Citations: 1     Fields:    Translation:Humans
  13. Lu L, Kanwar J, Schmitt S, Cui QC, Zhang C, Zhao C, Dou QP. Inhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'. Anticancer Res. 2011 Jan; 31(1):1-10. PMID: 21273574.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  14. Wan SB, Yang H, Zhou Z, Cui QC, Chen D, Kanwar J, Mohammad I, Dou QP, Chan TH. Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors. Int J Mol Med. 2010 Oct; 26(4):447-55. PMID: 20818481.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  15. Xiao Y, Chen DI, Zhang X, Cui Q, Fan Y, Bi C, Dou QP. Molecular study on copper-mediated tumor proteasome inhibition and cell death. Int J Oncol. 2010 Jul; 37(1):81-87. PMID: 20514399.
    Citations: 13     Fields:    Translation:HumansCells
  16. Liu SB, Liu YS, Li DF, Fan HT, Huai JY, Guo J, Wang L, Liu C, Zhang P, Cui Q, Jiang WH, Cao YC, Jiang N, Sui JH, Zhang B, Zhou J. [Relationship of motor deficits and imaging features in metastatic epidural spinal cord compression]. Zhonghua Yi Xue Za Zhi. 2010 Jun 15; 90(23):1606-8. PMID: 20979746.
    Citations:    Fields:    Translation:Humans
  17. Zhang H, Chen D, Ringler J, Chen W, Cui QC, Ethier SP, Dou QP, Wu G. Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo. Cancer Res. 2010 May 15; 70(10):3996-4004. PMID: 20424113.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  18. Huo C, Yang H, Cui QC, Dou QP, Chan TH. Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs. Bioorg Med Chem. 2010 Feb; 18(3):1252-8. PMID: 20045338.
    Citations: 15     Fields:    Translation:Humans
  19. Yang H, Sun DK, Chen D, Cui QC, Gu YY, Jiang T, Chen W, Wan SB, Dou QP. Antitumor activity of novel fluoro-substituted (-)-epigallocatechin-3-gallate analogs. Cancer Lett. 2010 Jun 01; 292(1):48-53. PMID: 19962231.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Yin Y, Cui Q, Gilbert HY, Yang Y, Yang Z, Berlinicke C, Li Z, Zaverucha-do-Valle C, He H, Petkova V, Zack DJ, Benowitz LI. Oncomodulin links inflammation to optic nerve regeneration. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19587-92. PMID: 19875691.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  21. Zhai S, Yang L, Cui QC, Sun Y, Dou QP, Yan B. Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells. J Biol Inorg Chem. 2010 Feb; 15(2):259-69. PMID: 19809836.
    Citations: 20     Fields:    Translation:HumansCells
  22. Frezza M, Hindo SS, Tomco D, Allard MM, Cui QC, Heeg MJ, Chen D, Dou QP, Verani CN. Comparative activities of nickel(II) and zinc(II) complexes of asymmetric [NN'O] ligands as 26S proteasome inhibitors. Inorg Chem. 2009 Jul 06; 48(13):5928-37. PMID: 19496541.
    Citations: 7     Fields:    Translation:HumansCells
  23. Yang H, Zhou P, Huang H, Chen D, Ma N, Cui QC, Shen S, Dong W, Zhang X, Lian W, Wang X, Dou QP, Liu J. Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int J Cancer. 2009 May 15; 124(10):2450-9. PMID: 19165859.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  24. Padhye S, Yang H, Jamadar A, Cui QC, Chavan D, Dominiak K, McKinney J, Banerjee S, Dou QP, Sarkar FH. New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in cancer cells. Pharm Res. 2009 Aug; 26(8):1874-80. PMID: 19421843.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  25. Zhang X, Bi C, Fan Y, Cui Q, Chen D, Xiao Y, Dou QP. Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity. Int J Mol Med. 2008 Nov; 22(5):677-82. PMID: 18949390.
    Citations: 8     Fields:    Translation:HumansCells
  26. Shi G, Chen D, Zhai G, Chen MS, Cui QC, Zhou Q, He B, Dou QP, Jiang G. The proteasome is a molecular target of environmental toxic organotins. Environ Health Perspect. 2009 Mar; 117(3):379-86. PMID: 19337512.
    Citations: 10     Fields:    Translation:HumansCells
  27. Fang X, Cui Q, Tong Y, Feng Y, Shan L, Huang L, Wang J. A stabilizing alpha/beta-hydrophobic core greatly contributes to hyperthermostability of archaeal [P62A]Ssh10b. Biochemistry. 2008 Oct 28; 47(43):11212-21. PMID: 18821773.
    Citations: 3     Fields:    Translation:Cells
  28. Yu Z, Qin XL, Gu YY, Chen D, Cui QC, Jiang T, Wan SB, Dou QP. Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers. Int J Mol Sci. 2008 Jun; 9(6):951-61. PMID: 19325839.
    Citations: 7     Fields:    
  29. Chen D, Falsetti SC, Frezza M, Milacic V, Kazi A, Cui QC, Long TE, Turos E, Dou QP. Anti-tumor activity of N-thiolated beta-lactam antibiotics. Cancer Lett. 2008 Sep 08; 268(1):63-9. PMID: 18468785.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  30. Yu Z, Wang F, Milacic V, Li X, Cui QC, Zhang B, Yan B, Dou QP. Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues. Int J Mol Med. 2007 Dec; 20(6):919-25. PMID: 17982703.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  31. Chen D, Frezza M, Shakya R, Cui QC, Milacic V, Verani CN, Dou QP. Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti prostate tumor effects. Cancer Res. 2007 Oct 01; 67(19):9258-65. PMID: 17909033.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  32. Pang H, Chen D, Cui QC, Dou QP. Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells. Int J Mol Med. 2007 May; 19(5):809-16. PMID: 17390087.
    Citations: 16     Fields:    Translation:HumansCells
  33. Chen D, Cui QC, Yang H, Barrea RA, Sarkar FH, Sheng S, Yan B, Reddy GP, Dou QP. Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts. Cancer Res. 2007 Feb 15; 67(4):1636-44. PMID: 17308104.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  34. Chen D, Chen MS, Cui QC, Yang H, Dou QP. Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells. Front Biosci. 2007 Jan 01; 12:1935-45. PMID: 17127432.
    Citations: 28     Fields:    Translation:HumansCells
  35. Chen D, Cui QC, Yang H, Dou QP. Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res. 2006 Nov 01; 66(21):10425-33. PMID: 17079463.
    Citations: 154     Fields:    Translation:HumansAnimals
  36. Landis-Piwowar KR, Chen D, Cui QC, Minic V, Becker FF, Banik BK, Dou QP. Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells. Int J Mol Med. 2006 May; 17(5):931-5. PMID: 16596283.
    Citations: 3     Fields:    Translation:HumansCells
  37. Yang H, Chen D, Cui QC, Yuan X, Dou QP. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 01; 66(9):4758-65. PMID: 16651429.
    Citations: 202     Fields:    Translation:HumansAnimalsCells
  38. Daniel KG, Chen D, Orlu S, Cui QC, Miller FR, Dou QP. Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells. Breast Cancer Res. 2005; 7(6):R897-908. PMID: 16280039.
    Citations: 66     Fields:    Translation:HumansCells
  39. Chen D, Peng F, Cui QC, Daniel KG, Orlu S, Liu J, Dou QP. Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis. Front Biosci. 2005 Sep 01; 10:2932-9. PMID: 15970547.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  40. Cui Q, Li G, Ma J, Karplus M. A normal mode analysis of structural plasticity in the biomolecular motor F(1)-ATPase. J Mol Biol. 2004 Jul 02; 340(2):345-72. PMID: 15201057.
    Citations: 58     Fields:    Translation:Cells
  41. Cui Q, Cho KS, So KF, Yip HK. Synergistic effect of Nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems. J Neurotrauma. 2004 May; 21(5):617-25. PMID: 15165369.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Mellough CB, Cui Q, Spalding KL, Symons NA, Pollett MA, Snyder EY, Macklis JD, Harvey AR. Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells. Exp Neurol. 2004 Mar; 186(1):6-19. PMID: 14980806.
    Citations: 13     Fields:    Translation:AnimalsCells
  43. Cui Q, Tong Y, Xue H, Huang L, Feng Y, Wang J. Two conformations of archaeal Ssh10b. The origin of its temperature-dependent interaction with DNA. J Biol Chem. 2003 Dec 19; 278(51):51015-22. PMID: 14523014.
    Citations: 11     Fields:    Translation:Cells
  44. Elstner M, Cui Q, Munih P, Kaxiras E, Frauenheim T, Karplus M. Modeling zinc in biomolecules with the self consistent charge-density functional tight binding (SCC-DFTB) method: applications to structural and energetic analysis. J Comput Chem. 2003 Apr 15; 24(5):565-81. PMID: 12632471.
    Citations: 40     Fields:    Translation:Cells
  45. Guo H, Cui Q, Lipscomb WN, Karplus M. Understanding the role of active-site residues in chorismate mutase catalysis from molecular-dynamics simulations. Angew Chem Int Ed Engl. 2003 Apr 04; 42(13):1508-11. PMID: 12698486.
    Citations: 8     Fields:    Translation:Cells
  46. Yin Y, Cui Q, Li Y, Irwin N, Fischer D, Harvey AR, Benowitz LI. Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci. 2003 Mar 15; 23(6):2284-93. PMID: 12657687.
    Citations: 134     Fields:    Translation:AnimalsCells
  47. Yang W, Gao YQ, Cui Q, Ma J, Karplus M. The missing link between thermodynamics and structure in F1-ATPase. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):874-9. PMID: 12552084.
    Citations: 33     Fields:    Translation:AnimalsCells
  48. Smedarchina Z, Siebrand W, Fern√°ndez-Ramos A, Cui Q. Kinetic isotope effects for concerted multiple proton transfer: a direct dynamics study of an active-site model of carbonic anhydrase II. J Am Chem Soc. 2003 Jan 08; 125(1):243-51. PMID: 12515527.
    Citations: 16     Fields:    Translation:Cells
  49. Cui Q, Karplus M. Catalysis and specificity in enzymes: a study of triosephosphate isomerase and comparison with methyl glyoxal synthase. Adv Protein Chem. 2003; 66:315-72. PMID: 14631822.
    Citations: 25     Fields:    Translation:Cells
  50. Ma J, Flynn TC, Cui Q, Leslie AG, Walker JE, Karplus M. A dynamic analysis of the rotation mechanism for conformational change in F(1)-ATPase. Structure. 2002 Jul; 10(7):921-31. PMID: 12121647.
    Citations: 54     Fields:    Translation:Cells
  51. Cui Q, Karplus M. Quantum mechanics/molecular mechanics studies of triosephosphate isomerase-catalyzed reactions: effect of geometry and tunneling on proton-transfer rate constants. J Am Chem Soc. 2002 Mar 27; 124(12):3093-124. PMID: 11902900.
    Citations: 33     Fields:    Translation:Cells
  52. Guo H, Cui Q, Lipscomb WN, Karplus M. Substrate conformational transitions in the active site of chorismate mutase: their role in the catalytic mechanism. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9032-7. PMID: 11481470.
    Citations: 14     Fields:    Translation:AnimalsCells
  53. Cui Q, Karplus M. Triosephosphate isomerase: a theoretical comparison of alternative pathways. J Am Chem Soc. 2001 Mar 14; 123(10):2284-90. PMID: 11456876.
    Citations: 25     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.