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profileTom A. Rapoport, Ph.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Cell Biology, Rm 613
45 Shattuck St
Boston MA 02115
Phone617/432-0637
Fax617/432-1190
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P41RR015301     (EALICK, STEVEN E)Jun 15, 2001 - Mar 31, 2013
NIH/NCRR
An Undulator Resource for Structural Biology
Role: Co-Principal Investigator

R01GM054238     (RAPOPORT, TOM A)May 1, 1996 - Apr 30, 2004
NIH/NIGMS
POSTTRANSLATIONAL PROTEIN TRANSPORT INTO YEAST ER
Role: Principal Investigator

R01GM052586     (RAPOPORT, TOM A)May 1, 1995 - Mar 31, 2019
NIH/NIGMS
Protein Transport Across Membranes
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tripathi A, Mandon EC, Gilmore R, Rapoport TA. Two alternative binding mechanisms connect the protein translocation Sec71/Sec72 complex with heat shock proteins. J Biol Chem. 2017 Mar 12. PMID: 28286332.
    View in: PubMed
  2. Powers RE, Wang S, Liu TY, Rapoport TA. Reconstitution of the tubular endoplasmic reticulum network with purified components. Nature. 2017 Mar 09; 543(7644):257-260. PMID: 28225760.
    View in: PubMed
  3. Wang S, Tukachinsky H, Romano FB, Rapoport TA. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife. 2016 Sep 13; 5. PMID: 27619977.
    View in: PubMed
  4. Baldridge RD, Rapoport TA. Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD. Cell. 2016 Jul 14; 166(2):394-407. PMID: 27321670; PMCID: PMC4946995 [Available on 07/14/17].
  5. Hu J, Rapoport TA. Fusion of the endoplasmic reticulum by membrane-bound GTPases. Semin Cell Dev Biol. 2016 Dec; 60:105-111. PMID: 27269373.
    View in: PubMed
  6. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396; PMCID: PMC4786681.
  7. Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA. Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature. 2016 Mar 17; 531(7594):395-9. PMID: 26950603; PMCID: PMC4855518.
  8. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1190-9. PMID: 26884191; PMCID: PMC4780648.
  9. Tan D, Blok NB, Rapoport TA, Walz T. Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis. FEBS J. 2016 Mar; 283(6):986-92. PMID: 26476099; PMCID: PMC4803591 [Available on 03/01/17].
  10. Junker M, Rapoport TA. Involvement of VAT-1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria. Traffic. 2015 Dec; 16(12):1306-17. PMID: 26394711.
    View in: PubMed
  11. Blok NB, Tan D, Wang RY, Penczek PA, Baker D, DiMaio F, Rapoport TA, Walz T. Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4017-25. PMID: 26170309; PMCID: PMC4522808.
  12. Chen Y, Bauer BW, Rapoport TA, Gumbart JC. Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol. 2015 Jul 17; 427(14):2348-59. PMID: 25982945; PMCID: PMC4472001.
  13. Liu TY, Bian X, Romano FB, Shemesh T, Rapoport TA, Hu J. Cis and trans interactions between atlastin molecules during membrane fusion. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1851-60. PMID: 25825753; PMCID: PMC4403200.
  14. Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D. Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon. J Cell Sci. 2015 Mar 15; 128(6):1217-29. PMID: 25616894; PMCID: PMC4359925.
  15. Shemesh T, Klemm RW, Romano FB, Wang S, Vaughan J, Zhuang X, Tukachinsky H, Kozlov MM, Rapoport TA. A model for the generation and interconversion of ER morphologies. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):E5243-51. PMID: 25404289; PMCID: PMC4267389.
  16. Stein A, Ruggiano A, Carvalho P, Rapoport TA. Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell. 2014 Sep 11; 158(6):1375-88. PMID: 25215493; PMCID: PMC4163015.
  17. Bauer BW, Shemesh T, Chen Y, Rapoport TA. A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase. Cell. 2014 Jun 05; 157(6):1416-29. PMID: 24906156; PMCID: PMC4104599.
  18. Markgraf DF, Klemm RW, Junker M, Hannibal-Bach HK, Ejsing CS, Rapoport TA. An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Cell Rep. 2014 Jan 16; 6(1):44-55. PMID: 24373967; PMCID: PMC3947819.
  19. Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013 Dec 09; 203(5):801-14. PMID: 24297752; PMCID: PMC3857478.
  20. Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW. Structure of the SecY channel during initiation of protein translocation. Nature. 2014 Feb 06; 506(7486):102-6. PMID: 24153188; PMCID: PMC3948209.
  21. Li L, Fierer JO, Rapoport TA, Howarth M. Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag. J Mol Biol. 2014 Jan 23; 426(2):309-17. PMID: 24161952; PMCID: PMC3959856.
  22. Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell. 2013 Jul 18; 154(2):285-96. PMID: 23870120; PMCID: PMC3767119.
  23. Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75. PMID: 23684613; PMCID: PMC3742324.
  24. Park E, Rapoport TA. Bacterial protein translocation requires only one copy of the SecY complex in vivo. J Cell Biol. 2012 Sep 03; 198(5):881-93. PMID: 22927464; PMCID: PMC3432775.
  25. Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J. Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):E2146-54. PMID: 22802620; PMCID: PMC3420179.
  26. Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA. The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol. 2012 Apr 16; 197(2):209-17. PMID: 22508509; PMCID: PMC3328390.
  27. Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012 Jun; 13(6):880-90. PMID: 22409400; PMCID: PMC3648210.
  28. Park E, Rapoport TA. Mechanisms of Sec61/SecY-mediated protein translocation across membranes. Annu Rev Biophys. 2012; 41:21-40. PMID: 22224601.
    View in: PubMed
  29. Hu J, Prinz WA, Rapoport TA. Weaving the web of ER tubules. Cell. 2011 Dec 09; 147(6):1226-31. PMID: 22153070; PMCID: PMC3478066.
  30. Park E, Rapoport TA. Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature. 2011 May 12; 473(7346):239-42. PMID: 21562565; PMCID: PMC3093665.
  31. Stanley AM, Carvalho P, Rapoport T. Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking. FEBS Lett. 2011 May 06; 585(9):1281-6. PMID: 21486563; PMCID: PMC3109430.
  32. Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 07; 192(5):825-38. PMID: 21357747; PMCID: PMC3051819.
  33. Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):3976-81. PMID: 21368113; PMCID: PMC3054032.
  34. Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA. Mechanisms determining the morphology of the peripheral ER. Cell. 2010 Nov 24; 143(5):774-88. PMID: 21111237; PMCID: PMC3008339.
  35. Rapoport TA. A preliminary report on my life in science. Mol Biol Cell. 2010 Nov 15; 21(22):3770-2. PMID: 21079005; PMCID: PMC2982106.
  36. Carvalho P, Stanley AM, Rapoport TA. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell. 2010 Nov 12; 143(4):579-91. PMID: 21074049; PMCID: PMC3026631.
  37. Schulman S, Wang B, Li W, Rapoport TA. Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15027-32. PMID: 20696932; PMCID: PMC2930587.
  38. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12. PMID: 20110994; PMCID: PMC2919313.
  39. Bauer BW, Rapoport TA. Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20800-5. PMID: 19933328.
    View in: PubMed
  40. Zimmer J, Rapoport TA. Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol. 2009 Dec 11; 394(4):606-12. PMID: 19850053; PMCID: PMC2832196.
  41. Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell. 2009 Aug 07; 138(3):549-61. PMID: 19665976; PMCID: PMC2746359.
  42. Shibata Y, Hu J, Kozlov MM, Rapoport TA. Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol. 2009; 25:329-54. PMID: 19575675.
    View in: PubMed
  43. Zimmer J, Nam Y, Rapoport TA. Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature. 2008 Oct 16; 455(7215):936-43. PMID: 18923516.
    View in: PubMed
  44. Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA. A role for the two-helix finger of the SecA ATPase in protein translocation. Nature. 2008 Oct 16; 455(7215):984-7. PMID: 18923526; PMCID: PMC4354775.
  45. Rapoport TA. Protein transport across the endoplasmic reticulum membrane. FEBS J. 2008 Sep; 275(18):4471-8. PMID: 18671729.
    View in: PubMed
  46. Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW. Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure. 2008 Jul; 16(7):1126-37. PMID: 18611385; PMCID: PMC2527209.
  47. Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem. 2008 Jul 04; 283(27):18892-904. PMID: 18442980; PMCID: PMC2441541.
  48. Goder V, Carvalho P, Rapoport TA. The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett. 2008 May 14; 582(11):1575-80. PMID: 18407841; PMCID: PMC2438607.
  49. Erlandson KJ, Or E, Osborne AR, Rapoport TA. Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem. 2008 Jun 06; 283(23):15709-15. PMID: 18359943; PMCID: PMC2409214.
  50. Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science. 2008 Feb 29; 319(5867):1247-50. PMID: 18309084.
    View in: PubMed
  51. Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW. Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell. 2007 Dec 28; 28(6):1083-92. PMID: 18158904.
    View in: PubMed
  52. Burton BM, Marquis KA, Sullivan NL, Rapoport TA, Rudner DZ. The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell. 2007 Dec 28; 131(7):1301-12. PMID: 18160039; PMCID: PMC2913279.
  53. Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA. The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol. 2007 Dec; 5(12):e322. PMID: 18052610; PMCID: PMC2100149.
  54. Rapoport TA. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature. 2007 Nov 29; 450(7170):663-9. PMID: 18046402.
    View in: PubMed
  55. Ye J, Cho SH, Fuselier J, Li W, Beckwith J, Rapoport TA. Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem. 2007 Nov 30; 282(48):34945-51. PMID: 17913712.
    View in: PubMed
  56. Saparov SM, Erlandson K, Cannon K, Schaletzky J, Schulman S, Rapoport TA, Pohl P. Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell. 2007 May 25; 26(4):501-9. PMID: 17531809.
    View in: PubMed
  57. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21. PMID: 17531810.
    View in: PubMed
  58. Or E, Rapoport T. Cross-linked SecA dimers are not functional in protein translocation. FEBS Lett. 2007 Jun 12; 581(14):2616-20. PMID: 17511989; PMCID: PMC2755086.
  59. Osborne AR, Rapoport TA. Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell. 2007 Apr 06; 129(1):97-110. PMID: 17418789.
    View in: PubMed
  60. Zimmer J, Li W, Rapoport TA. A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol. 2006 Dec 01; 364(3):259-65. PMID: 16989859.
    View in: PubMed
  61. Shibata Y, Voeltz GK, Rapoport TA. Rough sheets and smooth tubules. Cell. 2006 Aug 11; 126(3):435-9. PMID: 16901774.
    View in: PubMed
  62. Carvalho P, Goder V, Rapoport TA. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell. 2006 Jul 28; 126(2):361-73. PMID: 16873066.
    View in: PubMed
  63. Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11589-94. PMID: 16868077; PMCID: PMC1520313.
  64. Schaletzky J, Rapoport TA. Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane. Mol Biol Cell. 2006 Sep; 17(9):3860-9. PMID: 16822833; PMCID: PMC1593163.
  65. Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell. 2006 Feb 10; 124(3):573-86. PMID: 16469703.
    View in: PubMed
  66. Rapoport TA. Protein transport in and out of the endoplasmic reticulum. Harvey Lect. 2006-2007; 102:51-72. PMID: 20166563.
    View in: PubMed
  67. Ye Y, Shibata Y, Kikkert M, van Voorden S, Wiertz E, Rapoport TA. Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A. 2005 Oct 04; 102(40):14132-8. PMID: 16186510; PMCID: PMC1242302.
  68. Kothe M, Ye Y, Wagner JS, De Luca HE, Kern E, Rapoport TA, Lencer WI. Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem. 2005 Jul 29; 280(30):28127-32. PMID: 15932873.
    View in: PubMed
  69. Ménétret JF, Hegde RS, Heinrich SU, Chandramouli P, Ludtke SJ, Rapoport TA, Akey CW. Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol. 2005 Apr 29; 348(2):445-57. PMID: 15811380.
    View in: PubMed
  70. Cannon KS, Or E, Clemons WM, Shibata Y, Rapoport TA. Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol. 2005 Apr 25; 169(2):219-25. PMID: 15851514; PMCID: PMC2171872.
  71. Heinrich R, Rapoport TA. Generation of nonidentical compartments in vesicular transport systems. J Cell Biol. 2005 Jan 17; 168(2):271-80. PMID: 15657397; PMCID: PMC2171580.
  72. Osborne AR, Rapoport TA, van den Berg B. Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol. 2005; 21:529-50. PMID: 16212506.
    View in: PubMed
  73. Or E, Boyd D, Gon S, Beckwith J, Rapoport T. The bacterial ATPase SecA functions as a monomer in protein translocation. J Biol Chem. 2005 Mar 11; 280(10):9097-105. PMID: 15618215.
    View in: PubMed
  74. Ye J, Osborne AR, Groll M, Rapoport TA. RecA-like motor ATPases--lessons from structures. Biochim Biophys Acta. 2004 Nov 04; 1659(1):1-18. PMID: 15511523.
    View in: PubMed
  75. Rapoport TA, Goder V, Heinrich SU, Matlack KE. Membrane-protein integration and the role of the translocation channel. Trends Cell Biol. 2004 Oct; 14(10):568-75. PMID: 15450979.
    View in: PubMed
  76. Clemons WM, Ménétret JF, Akey CW, Rapoport TA. Structural insight into the protein translocation channel. Curr Opin Struct Biol. 2004 Aug; 14(4):390-6. PMID: 15313231.
    View in: PubMed
  77. Osborne AR, Clemons WM, Rapoport TA. A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):10937-42. PMID: 15256599; PMCID: PMC491988.
  78. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 2004 Jun 24; 429(6994):841-7. PMID: 15215856.
    View in: PubMed
  79. van den Berg B, Black PN, Clemons WM, Rapoport TA. Crystal structure of the long-chain fatty acid transporter FadL. Science. 2004 Jun 04; 304(5676):1506-9. PMID: 15178802.
    View in: PubMed
  80. Van den Berg B, Clemons WM, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA. X-ray structure of a protein-conducting channel. Nature. 2004 Jan 01; 427(6969):36-44. PMID: 14661030.
    View in: PubMed
  81. Plath K, Wilkinson BM, Stirling CJ, Rapoport TA. Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell. 2004 Jan; 15(1):1-10. PMID: 14617809; PMCID: PMC307522.
  82. Le Gall S, Neuhof A, Rapoport T. The endoplasmic reticulum membrane is permeable to small molecules. Mol Biol Cell. 2004 Feb; 15(2):447-55. PMID: 14617815; PMCID: PMC329208.
  83. Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI. Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell. 2003 Dec; 14(12):4783-93. PMID: 13679513; PMCID: PMC284783.
  84. Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA. Gangliosides are receptors for murine polyoma virus and SV40. EMBO J. 2003 Sep 01; 22(17):4346-55. PMID: 12941687; PMCID: PMC202381.
  85. Heinrich SU, Rapoport TA. Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J. 2003 Jul 15; 22(14):3654-63. PMID: 12853480; PMCID: PMC165616.
  86. Ye Y, Meyer HH, Rapoport TA. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol. 2003 Jul 07; 162(1):71-84. PMID: 12847084; PMCID: PMC2172719.
  87. Flierman D, Ye Y, Dai M, Chau V, Rapoport TA. Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. J Biol Chem. 2003 Sep 12; 278(37):34774-82. PMID: 12813030.
    View in: PubMed
  88. Morgan DG, Ménétret JF, Neuhof A, Rapoport TA, Akey CW. Structure of the mammalian ribosome-channel complex at 17A resolution. J Mol Biol. 2002 Dec 06; 324(4):871-86. PMID: 12460584.
    View in: PubMed
  89. Rodighiero C, Tsai B, Rapoport TA, Lencer WI. Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep. 2002 Dec; 3(12):1222-7. PMID: 12446567; PMCID: PMC1308323.
  90. Tsai B, Rapoport TA. Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1. J Cell Biol. 2002 Oct 28; 159(2):207-16. PMID: 12403808; PMCID: PMC2173060.
  91. Voeltz GK, Rolls MM, Rapoport TA. Structural organization of the endoplasmic reticulum. EMBO Rep. 2002 Oct; 3(10):944-50. PMID: 12370207; PMCID: PMC1307613.
  92. Or E, Navon A, Rapoport T. Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane. EMBO J. 2002 Sep 02; 21(17):4470-9. PMID: 12198149; PMCID: PMC126201.
  93. Stein PA, Toret CP, Salic AN, Rolls MM, Rapoport TA. A novel centrosome-associated protein with affinity for microtubules. J Cell Sci. 2002 Sep 01; 115(Pt 17):3389-402. PMID: 12154070.
    View in: PubMed
  94. Breyton C, Haase W, Rapoport TA, Kühlbrandt W, Collinson I. Three-dimensional structure of the bacterial protein-translocation complex SecYEG. Nature. 2002 Aug 08; 418(6898):662-5. PMID: 12167867.
    View in: PubMed
  95. Rapoport T. Profile: Tom Rapoport interviewed by Rabiya S. Tuma. Trends Cell Biol. 2002 Jun; 12(6):288-9. PMID: 12074889.
    View in: PubMed
  96. Heinrich R, Neel BG, Rapoport TA. Mathematical models of protein kinase signal transduction. Mol Cell. 2002 May; 9(5):957-70. PMID: 12049733.
    View in: PubMed
  97. Rolls MM, Hall DH, Victor M, Stelzer EH, Rapoport TA. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell. 2002 May; 13(5):1778-91. PMID: 12006669; PMCID: PMC111143.
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  99. Ye Y, Meyer HH, Rapoport TA. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature. 2001 Dec 06; 414(6864):652-6. PMID: 11740563.
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  100. Horwich AL, Fenton WA, Rapoport TA. Protein folding taking shape. Workshop on molecular chaperones. EMBO Rep. 2001 Dec; 2(12):1068-73. PMID: 11743017; PMCID: PMC1084171.
  101. Verhey KJ, Rapoport TA. Kinesin carries the signal. Trends Biochem Sci. 2001 Sep; 26(9):545-50. PMID: 11551791.
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  102. Shamu CE, Flierman D, Ploegh HL, Rapoport TA, Chau V. Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol Biol Cell. 2001 Aug; 12(8):2546-55. PMID: 11514634; PMCID: PMC58612.
  103. Collinson I, Breyton C, Duong F, Tziatzios C, Schubert D, Or E, Rapoport T, Kühlbrandt W. Projection structure and oligomeric properties of a bacterial core protein translocase. EMBO J. 2001 May 15; 20(10):2462-71. PMID: 11350935; PMCID: PMC125464.
  104. Tsai B, Rodighiero C, Lencer WI, Rapoport TA. Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell. 2001 Mar 23; 104(6):937-48. PMID: 11290330.
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  105. Verhey KJ, Meyer D, Deehan R, Blenis J, Schnapp BJ, Rapoport TA, Margolis B. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J Cell Biol. 2001 Mar 05; 152(5):959-70. PMID: 11238452; PMCID: PMC2198804.
  106. Liebermeister W, Rapoport TA, Heinrich R. Ratcheting in post-translational protein translocation: a mathematical model. J Mol Biol. 2001 Jan 19; 305(3):643-56. PMID: 11152619.
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  107. Menetret JF, Neuhof A, Morgan DG, Plath K, Radermacher M, Rapoport TA, Akey CW. The structure of ribosome-channel complexes engaged in protein translocation. Mol Cell. 2000 Nov; 6(5):1219-32. PMID: 11106759.
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  108. Plath K, Rapoport TA. Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum. J Cell Biol. 2000 Oct 02; 151(1):167-78. PMID: 11018062; PMCID: PMC2189806.
  109. Morgan DG, Ménétret JF, Radermacher M, Neuhof A, Akey IV, Rapoport TA, Akey CW. A comparison of the yeast and rabbit 80 S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments. J Mol Biol. 2000 Aug 11; 301(2):301-21. PMID: 10926511.
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  110. Prinz WA, Grzyb L, Veenhuis M, Kahana JA, Silver PA, Rapoport TA. Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Biol. 2000 Aug 07; 150(3):461-74. PMID: 10931860; PMCID: PMC2175198.
  111. Heinrich SU, Mothes W, Brunner J, Rapoport TA. The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell. 2000 Jul 21; 102(2):233-44. PMID: 10943843.
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  112. Prinz A, Behrens C, Rapoport TA, Hartmann E, Kalies KU. Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA. EMBO J. 2000 Apr 17; 19(8):1900-6. PMID: 10775273; PMCID: PMC302021.
  113. Dreier L, Rapoport TA. In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction. J Cell Biol. 2000 Mar 06; 148(5):883-98. PMID: 10704440; PMCID: PMC2174540.
  114. Hinkle B, Rolls MM, Stein P, Rapoport T, Terasaki M. Ran is associated with chromosomes during starfish oocyte meiosis and embryonic mitoses. Zygote. 2000; 8 Suppl 1:S91. PMID: 11191341.
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  115. Shamu CE, Story CM, Rapoport TA, Ploegh HL. The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol. 1999 Oct 04; 147(1):45-58. PMID: 10508854; PMCID: PMC2164983.
  116. Rapoport TA, Matlack KE, Plath K, Misselwitz B, Staeck O. Posttranslational protein translocation across the membrane of the endoplasmic reticulum. Biol Chem. 1999 Oct; 380(10):1143-50. PMID: 10595576.
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  117. Schröder K, Martoglio B, Hofmann M, Hölscher C, Hartmann E, Prehn S, Rapoport TA, Dobberstein B. Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J. 1999 Sep 01; 18(17):4804-15. PMID: 10469658; PMCID: PMC1171552.
  118. Misselwitz B, Staeck O, Matlack KE, Rapoport TA. Interaction of BiP with the J-domain of the Sec63p component of the endoplasmic reticulum protein translocation complex. J Biol Chem. 1999 Jul 16; 274(29):20110-5. PMID: 10400622.
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  119. Rolls MM, Stein PA, Taylor SS, Ha E, McKeon F, Rapoport TA. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol. 1999 Jul 12; 146(1):29-44. PMID: 10402458; PMCID: PMC2199743.
  120. Matlack KE, Misselwitz B, Plath K, Rapoport TA. BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane. Cell. 1999 May 28; 97(5):553-64. PMID: 10367885.
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  121. Meyer TH, Ménétret JF, Breitling R, Miller KR, Akey CW, Rapoport TA. The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex. J Mol Biol. 1999 Jan 29; 285(4):1789-800. PMID: 9917412.
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  122. Verhey KJ, Lizotte DL, Abramson T, Barenboim L, Schnapp BJ, Rapoport TA. Light chain-dependent regulation of Kinesin's interaction with microtubules. J Cell Biol. 1998 Nov 16; 143(4):1053-66. PMID: 9817761; PMCID: PMC2132950.
  123. Misselwitz B, Staeck O, Rapoport TA. J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences. Mol Cell. 1998 Nov; 2(5):593-603. PMID: 9844632.
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  124. Plath K, Mothes W, Wilkinson BM, Stirling CJ, Rapoport TA. Signal sequence recognition in posttranslational protein transport across the yeast ER membrane. Cell. 1998 Sep 18; 94(6):795-807. PMID: 9753326.
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  125. Mothes W, Jungnickel B, Brunner J, Rapoport TA. Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane. J Cell Biol. 1998 Jul 27; 142(2):355-64. PMID: 9679136; PMCID: PMC2133054.
  126. Kalies KU, Rapoport TA, Hartmann E. The beta subunit of the Sec61 complex facilitates cotranslational protein transport and interacts with the signal peptidase during translocation. J Cell Biol. 1998 May 18; 141(4):887-94. PMID: 9585408; PMCID: PMC2132780.
  127. Hegde RS, Voigt S, Rapoport TA, Lingappa VR. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum. Cell. 1998 Mar 06; 92(5):621-31. PMID: 9506517.
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  128. Matlack KE, Mothes W, Rapoport TA. Protein translocation: tunnel vision. Cell. 1998 Feb 06; 92(3):381-90. PMID: 9476897.
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  129. Neuhof A, Rolls MM, Jungnickel B, Kalies KU, Rapoport TA. Binding of signal recognition particle gives ribosome/nascent chain complexes a competitive advantage in endoplasmic reticulum membrane interaction. Mol Biol Cell. 1998 Jan; 9(1):103-15. PMID: 9436994; PMCID: PMC25224.
  130. Helman S, Rapoport T. Women in black: challenging Israel's gender and socio-political orders. Br J Sociol. 1997 Dec; 48(4):681-700. PMID: 9421959.
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  131. Matlack KE, Plath K, Misselwitz B, Rapoport TA. Protein transport by purified yeast Sec complex and Kar2p without membranes. Science. 1997 Aug 15; 277(5328):938-41. PMID: 9252322.
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  132. Mothes W, Heinrich SU, Graf R, Nilsson I, von Heijne G, Brunner J, Rapoport TA. Molecular mechanism of membrane protein integration into the endoplasmic reticulum. Cell. 1997 May 16; 89(4):523-33. PMID: 9160744.
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  133. Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 1996 Dec 05; 384(6608):432-8. PMID: 8945469.
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  134. Hanein D, Matlack KE, Jungnickel B, Plath K, Kalies KU, Miller KR, Rapoport TA, Akey CW. Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation. Cell. 1996 Nov 15; 87(4):721-32. PMID: 8929540.
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  135. Rapoport TA, Rolls MM, Jungnickel B. Approaching the mechanism of protein transport across the ER membrane. Curr Opin Cell Biol. 1996 Aug; 8(4):499-504. PMID: 8791447.
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  136. Voigt S, Jungnickel B, Hartmann E, Rapoport TA. Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane. J Cell Biol. 1996 Jul; 134(1):25-35. PMID: 8698819; PMCID: PMC2120911.
  137. Bacher G, Lütcke H, Jungnickel B, Rapoport TA, Dobberstein B. Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting. Nature. 1996 May 16; 381(6579):248-51. PMID: 8622769.
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  138. Ahnert-Hilger G, Kutay U, Chahoud I, Rapoport T, Wiedenmann B. Synaptobrevin is essential for secretion but not for the development of synaptic processes. Eur J Cell Biol. 1996 May; 70(1):1-11. PMID: 8738414.
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  139. Finke K, Plath K, Panzner S, Prehn S, Rapoport TA, Hartmann E, Sommer T. A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae. EMBO J. 1996 Apr 01; 15(7):1482-94. PMID: 8612571; PMCID: PMC450055.
  140. Whitley P, Grahn E, Kutay U, Rapoport TA, von Heijne G. A 12-residue-long polyleucine tail is sufficient to anchor synaptobrevin to the endoplasmic reticulum membrane. J Biol Chem. 1996 Mar 29; 271(13):7583-6. PMID: 8631791.
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  141. Rapoport TA, Jungnickel B, Kutay U. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes. Annu Rev Biochem. 1996; 65:271-303. PMID: 8811181.
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  142. Lyko F, Martoglio B, Jungnickel B, Rapoport TA, Dobberstein B. Signal sequence processing in rough microsomes. J Biol Chem. 1995 Aug 25; 270(34):19873-8. PMID: 7650000.
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  143. Jungnickel B, Rapoport TA. A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane. Cell. 1995 Jul 28; 82(2):261-70. PMID: 7628015.
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  144. Panzner S, Dreier L, Hartmann E, Kostka S, Rapoport TA. Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell. 1995 May 19; 81(4):561-70. PMID: 7758110.
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  145. Oliver J, Jungnickel B, Görlich D, Rapoport T, High S. The Sec61 complex is essential for the insertion of proteins into the membrane of the endoplasmic reticulum. FEBS Lett. 1995 Apr 03; 362(2):126-30. PMID: 7720858.
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  146. Kutay U, Ahnert-Hilger G, Hartmann E, Wiedenmann B, Rapoport TA. Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. EMBO J. 1995 Jan 16; 14(2):217-23. PMID: 7835332; PMCID: PMC398073.
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  148. Mothes W, Prehn S, Rapoport TA. Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane. EMBO J. 1994 Sep 01; 13(17):3973-82. PMID: 8076593; PMCID: PMC395317.
  149. Kalies KU, Görlich D, Rapoport TA. Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex. J Cell Biol. 1994 Aug; 126(4):925-34. PMID: 8051212; PMCID: PMC2120124.
  150. Jungnickel B, Rapoport TA, Hartmann E. Protein translocation: common themes from bacteria to man. FEBS Lett. 1994 Jun 06; 346(1):73-7. PMID: 8206162.
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  151. Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA. Evolutionary conservation of components of the protein translocation complex. Nature. 1994 Feb 17; 367(6464):654-7. PMID: 8107851.
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  152. High S, Martoglio B, Görlich D, Andersen SS, Ashford AJ, Giner A, Hartmann E, Prehn S, Rapoport TA, Dobberstein B, et al. Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. J Biol Chem. 1993 Dec 15; 268(35):26745-51. PMID: 8253810.
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  153. Görlich D, Rapoport TA. Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane. Cell. 1993 Nov 19; 75(4):615-30. PMID: 8242738.
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  154. Jungnickel B, Rapoport TA. DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid) inhibits an early step of protein translocation across the mammalian ER membrane. FEBS Lett. 1993 Aug 30; 329(3):268-72. PMID: 8396042.
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  155. Hartmann E, Görlich D, Kostka S, Otto A, Kraft R, Knespel S, Bürger E, Rapoport TA, Prehn S. A tetrameric complex of membrane proteins in the endoplasmic reticulum. Eur J Biochem. 1993 Jun 01; 214(2):375-81. PMID: 7916687.
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  156. High S, Andersen SS, Görlich D, Hartmann E, Prehn S, Rapoport TA, Dobberstein B. Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion. J Cell Biol. 1993 May; 121(4):743-50. PMID: 8491769; PMCID: PMC2119797.
  157. Kutay U, Hartmann E, Rapoport TA. A class of membrane proteins with a C-terminal anchor. Trends Cell Biol. 1993 Mar; 3(3):72-5. PMID: 14731773.
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  160. Hartmann E, Rapoport TA, Prehn S. Signal sequence identified. Nature. 1992 Jul 16; 358(6383):198. PMID: 1321345.
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  162. Müsch A, Wiedmann M, Rapoport TA. Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane. Cell. 1992 Apr 17; 69(2):343-52. PMID: 1568249.
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  166. High S, Görlich D, Wiedmann M, Rapoport TA, Dobberstein B. The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER. J Cell Biol. 1991 Apr; 113(1):35-44. PMID: 1848866; PMCID: PMC2288910.
  167. Rapoport T. Gender-differential patterns of adolescent socialization in three arenas. J Youth Adolesc. 1991 Feb; 20(1):31-51. PMID: 24264915.
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  168. Rapoport TA. Protein translocation. A bacterium catches up. Nature. 1991 Jan 10; 349(6305):107-8. PMID: 1846029.
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  170. Vogel F, Hartmann E, Görlich D, Rapoport TA. Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane. Eur J Cell Biol. 1990 Dec; 53(2):197-202. PMID: 1964414.
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  171. Görlich D, Prehn S, Hartmann E, Herz J, Otto A, Kraft R, Wiedmann M, Knespel S, Dobberstein B, Rapoport TA. The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents. J Cell Biol. 1990 Dec; 111(6 Pt 1):2283-94. PMID: 2177473; PMCID: PMC2116355.
  172. Rapoport TA. Protein transport across the ER membrane. Trends Biochem Sci. 1990 Sep; 15(9):355-8. PMID: 2238046.
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  174. Cohen-Shalev A, Rapoport T. Developmental assumptions in literary criticism and their implications for conceptions of continuity and change in literary creativity. Psychol Aging. 1990 Mar; 5(1):79-85. PMID: 2317304.
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  175. Muesch A, Hartmann E, Rohde K, Rubartelli A, Sitia R, Rapoport TA. A novel pathway for secretory proteins? Trends Biochem Sci. 1990 Mar; 15(3):86-8. PMID: 2139259.
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  176. Wiedmann M, Goerlich D, Hartmann E, Kurzchalia TV, Rapoport TA. Photocrosslinking demonstrates proximity of a 34 kDa membrane protein to different portions of preprolactin during translocation through the endoplasmic reticulum. FEBS Lett. 1989 Nov 06; 257(2):263-8. PMID: 2583273.
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  177. Bernstein HD, Rapoport TA, Walter P. Cytosolic protein translocation factors. Is SRP still unique? Cell. 1989 Sep 22; 58(6):1017-9. PMID: 2550141.
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  179. Hartmann E, Rapoport TA, Lodish HF. Predicting the orientation of eukaryotic membrane-spanning proteins. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5786-90. PMID: 2762295; PMCID: PMC297715.
  180. Rapoport T, Rosenhek Z. Complex role experiences and personal differentiation: a real-life experiment. J Adolesc. 1989 Jun; 12(2):207-19. PMID: 2768601.
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  182. Huth A, Petrukhin KE, Modyanov NN, Rapoport TA. SRP-dependent membrane integration of the beta-subunit of Na+,K+-ATPase. Biomed Biochim Acta. 1989; 48(1):77-84. PMID: 2549983.
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  183. Wiedmann M, Wiedmann B, Voigt S, Wachter E, Müller HG, Rapoport TA. Post-translational transport of proteins into microsomal membranes of Candida maltosa. EMBO J. 1988 Jun; 7(6):1763-8. PMID: 3169003; PMCID: PMC457166.
  184. Bassüner R, Bäumlein H, Huth A, Jung R, Wobus U, Rapoport TA, Saalbach G, Müntz K. Abundant embryonic mRNA in field bean (Vicia faba L.) codes for a new class of seed proteins: cDNA cloning and characterization of the primary translation product. Plant Mol Biol. 1988 May; 11(3):321-34. PMID: 24272345.
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  185. Kurzchalia TV, Wiedmann M, Breter H, Zimmermann W, Bauschke E, Rapoport TA. tRNA-mediated labelling of proteins with biotin. A nonradioactive method for the detection of cell-free translation products. Eur J Biochem. 1988 Mar 15; 172(3):663-8. PMID: 3350017.
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  186. Bassuner R, Baumlein H, Huth A, Jung R, Wobus U, Rapoport TA, Saalbach G, Müntz K. Abundant embryonic mRNA in field been (Vicin faba L.) codes for a new class of seed proteins: cDNA cloning and characterization of the primary translation product. Plant Mol Biol. 1988; II:321-34.
  187. Wiedmann M, Kurzchalia TV, Hartmann E, Rapoport TA. A signal sequence receptor in the endoplasmic reticulum membrane. Nature. 1987 Aug 27-Sep 2; 328(6133):830-3. PMID: 3041222.
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  188. Prehn S, Wiedmann M, Rapoport TA, Zwieb C. Protein translocation across wheat germ microsomal membranes requires an SRP-like component. EMBO J. 1987 Jul; 6(7):2093-7. PMID: 16453782.
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  190. Wiedmann M, Kurzchalia TV, Bielka H, Rapoport TA. Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking. J Cell Biol. 1987 Feb; 104(2):201-8. PMID: 3643215; PMCID: PMC2114417.
  191. Kurzchalia TV, Wiedmann M, Girshovich AS, Bochkareva ES, Bielka H, Rapoport TA. The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle. Nature. 1986 Apr 17-23; 320(6063):634-6. PMID: 3010127.
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  193. Rapoport TA. Protein translocation across and integration into membranes. CRC Crit Rev Biochem. 1986; 20(1):73-137. PMID: 3007024.
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  194. Wiedmann M, Huth A, Rapoport TA. Internally transposed signal sequence of carp preproinsulin retains its functions with the signal recognition particle. FEBS Lett. 1986 Jan 01; 194(1):139-45. PMID: 3000822.
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  195. Rapoport TA. Extensions of the signal hypothesis--sequential insertion model versus amphipathic tunnel hypothesis. FEBS Lett. 1985 Jul 22; 187(1):1-10. PMID: 3160605.
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  197. Rapoport TA, Wiedmann M. Application of the signal hypothesis to the incorporation of integral membrane proteins. Curr Top Mem Trans. 1985; 24:1-62.
  198. Wiedmann M, Huth A, Rapoport TA. Xenopus oocytes can secrete bacterial beta-lactamase. Nature. 1984 Jun 14-20; 309(5969):637-9. PMID: 6374471.
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  199. Huth A, Rapoport TA, Kääriäinen L. Envelope proteins of Semliki Forest virus synthesized in Xenopus oocytes are transported to the cell surface. EMBO J. 1984 Apr; 3(4):767-71. PMID: 6373249; PMCID: PMC557424.
  200. Bassüner R, Wobus U, Rapoport TA. Signal recognition particle triggers the translocation of storage globulin polypeptides from field beans (Vicia faba L.) across mammalian endoplasmic reticulum membrane. FEBS Lett. 1984 Jan 30; 166(2):314-20. PMID: 6198216.
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  201. Pfeiffer M, Hahn V, Huth A, Liebscher DH, Pöhlmann CH, Rapoport TA, Rosenthal S, Tran-Batcke A, Wolf M. Expression of the DNA sequence coding for carp preproinsulin in E.coli-initiation of translation at the eukaryotic start condon. Biol Zbl. 1984; 103:637-47.
  202. Hahn V, Winkler J, Rapoport TA, Liebscher DH, Coutelle C, Rosenthal S. Carp preproinsulin cDNA sequence and evolution of insulin genes. Folia Biol (Praha). 1984; 30 Spec No:72-82. PMID: 6373397.
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  203. Finkelstein AV, Bendzko P, Rapoport TA. Recognition of signal sequences. FEBS Lett. 1983 Sep 19; 161(2):176-9. PMID: 6617872.
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  204. Hahn V, Winkler J, Rapoport TA, Liebscher DH, Coutelle C, Rosenthal S. Carp preproinsulin cDNA sequence and evolution of insulin genes. Nucleic Acids Res. 1983 Jul 11; 11(13):4541-52. PMID: 6306593; PMCID: PMC326063.
  205. Bassüner R, Huth A, Manteuffel R, Rapoport TA. Secretion of plant storage globulin polypeptides by Xenopus laevis oocytes. Eur J Biochem. 1983 Jun 15; 133(2):321-6. PMID: 6852043.
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  206. Rapoport TA, Huth A, Proesch S, Bendzko P, Kaeaeriaeinen L, Bassuner R, Manteuffel R, Finkelstein A. Transport of proteins and signal recognition. Protein synthesis (Abraham AKK, Eikhom TS, Pryme IF). 1983; 81-100.
  207. Hahn V, Winkler J, Rapoport TA, Liebscher DH, Coutelle CH, Rosenthal S. Carp preproinsulin cDNA sequence and evolution of insulin genes. Nucl Acid Res. 1983; 11:4541-52.
  208. Bendzko P, Prehn S, Pfeil W, Rapoport TA. Different modes of membrane interactions of the signal sequence of carp preproinsulin and of the insertion sequence of rabbit cytochrome b5. Eur J Biochem. 1982 Mar; 123(1):121-6. PMID: 7067693.
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  209. Huth A, Rapoport TA. Regulation of the biosynthesis of insulin in isolated Brockmann bodies of the carp (Cyprinus carpio). Gen Comp Endocrinol. 1982 Feb; 46(2):158-67. PMID: 7049828.
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  210. Makower A, Dettmer R, Rapoport TA, Knospe S, Behlke J, Prehn S, Franke P, Etzold G, Rosenthal S. Carp insulin: amino acid sequence, biological activity and structural properties. Eur J Biochem. 1982 Feb; 122(2):339-45. PMID: 7037403.
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  211. Rapoport TA. Intracellular compartmentation and secretion of carp proinsulin synthesized in Xenopus oocytes. Eur J Biochem. 1981 Apr; 115(3):665-9. PMID: 7238527.
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  212. Prehn S, Nürnberg P, Rapoport TA. A receptor for single segments of secretory proteins in rough endoplasmic reticulum membranes. FEBS Lett. 1981 Jan 12; 123(1):79-84. PMID: 6258987.
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  213. Huth A, Rapoport TA. Regulation of insulin biosynthesis in carp islets (Cyprinus carpio). Acta Biol Med Ger. 1981; 40(1):87-92. PMID: 7020309.
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  214. Heinrich R, Rapoport TA. Mathematical modelling of translation of mRNA in eucaryotes; steady state, time-dependent processes and application to reticulocytes. J Theor Biol. 1980 Sep 21; 86(2):279-313. PMID: 7442295.
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  215. Liebscher DH, Coutelle C, Rapoport TA, Hahn V, Rosenthal S, Prehn S, Williamson R. Cloning of carp preproinsulin cDNA in the bacterial plasmid pBR322. Gene. 1980 May; 9(3-4):233-46. PMID: 6993287.
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  216. Rapoport TA, Prehn S, Tsamaloukas A, Coutelle CH, Liebscher DH, Huth A, Rosenthal S. Biosynthesis of proinsulin of carp (cyrpinus carpio) and characterization and cloning of mRNA. Ann NY Acad Sci. 1980; 343:111-32.
  217. Prehn S, Tsamaloukas A, Rapoport TA. Demonstration of specific receptors of the rough endoplasmic membrane for the signal sequence of carp preproinsulin. Eur J Biochem. 1980; 107(1):185-95. PMID: 6249584.
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  218. Rapoport TA, Prehn S, Tsamaloukas A, Coutelle C, Liebscher DH, Huth A, Rosenthal S. Biosynthesis of proinsulin of carp (Cyprinus carpio) and characterization and cloning of mRNA. Ann N Y Acad Sci. 1980; 343:111-32. PMID: 6994550.
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  219. Heinrich R, Rapoport TA. Mathematical modeling of translation of mRNA in eukaryotes; steady states, time-dependent processes and application to reticulocytes. J Theoret Biol. 1980; 86:279-313.
  220. Rapoport TA, Prehn S, Huth A, Tsamaloukas A. Biosynthesis of proinsulin of carp. Physiol Sci. 1980; 13:135-46.
  221. Thiele BJ, Belkner J, Andree H, Rapoport TA, Rapoport SM. Synthesis of non-globin proteins in rabbit-erythroid cells. Synthesis of a lipoxygenase in reticulocytes. Eur J Biochem. 1979 Jun 01; 96(3):563-9. PMID: 111926.
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  222. Grosse R, Rapoport T, Malur J, Fischer J, Repke KR. Mathematical modelling of ATP, K+ and Na+ interactions with (Na+ + K+)-ATPase occurring under equilibrium conditions. Biochim Biophys Acta. 1979 Feb 02; 550(3):500-14. PMID: 217431.
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  223. Rosenthal S, Coutelle CH, Hahn V, Liebscher DH, Rapoport TA. Cloning of vertebrate genes in E.coli; perspective for basic research, technical microbiology and medicine/considering own data. Studia biophysica. 1979; 76:147-8.
  224. Grosse R, Rapoport TA, Malur J, Fischer J, Repke KRH. Mathematical modeling of ATP, K+ and Na+ interactions with the Na+-K+) -ATPase occurring under equilibrium conditions. Biochim Biophys Acta. 1979; 550:500-14.
  225. Rapoport TA, Thiele BJ, Prehn S, Marbaix G, Cleuter Y, Hubert E, Huez G. Synthesis of carp proinsulin in Xenopus oocytes. Eur J Biochem. 1978 Jun 15; 87(2):229-33. PMID: 668692.
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  226. Rapoport TA, Kohnert KD, Knospe S, Lukowsky A, Prehn S, Schäfer H, Schmidt S, Ziegler M. Preparation and characterization of insulin of carp (Cyprinus carpio). Acta Biol Med Ger. 1978; 37(8):1153-60. PMID: 373345.
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  227. Rapoport I, Rapoport TA, Rapoport SM. Analysis of pH-induced changes of the glycolysis of human erythrocytes. Acta Biol Med Ger. 1978; 37(3):393-401. PMID: 32713.
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  228. Goor A, Rapoport T. Enhancing creativity in an informal educational framework. J Educ Psychol. 1977 Oct; 69(5):636-43. PMID: 908785.
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  229. Schulz J, Baufeld A, Hofmann E, Rapoport TA, Heinrich R, Rapoport SM. Regulation of anaerobic glycolysis in Ehrlich ascites tumour cells. Acta Biol Med Ger. 1977; 36(10):1379-91. PMID: 28629.
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  230. Rapoport TA, Heinrich R. Modellierung metabolischer systeme. Mathematische Modell-bildung, Akademie/Verl. 1977; 208-19.
  231. Heinrich R, Rapoport SM, Rapoport TA. Metabolic regulation and mathematical models. Prog Biophys Mol Biol. 1977; 32(1):1-82. PMID: 343173.
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  232. Rapoport TA, Otto M, Heinrich R. An extended model of the glycolysis in erythrocytes. Acta Biol Med Ger. 1977; 36(3-4):461-8. PMID: 145774.
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  233. Rapoport TA, Klatt D, Prehn S, Hahn V, Höhne WE. Evidence for the synthesis of a precursor of carp proinsulin in a cell-free translation system. FEBS Lett. 1976 Oct 15; 69(1):32-6. PMID: 791674.
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  234. Rapoport TA, Heinrich R, Rapoport SM. The regulatory principles of glycolysis in erythrocytes in vivo and in vitro. A minimal comprehensive model describing steady states, quasi-steady states and time-dependent processes. Biochem J. 1976 Feb 15; 154(2):449-69. PMID: 132930; PMCID: PMC1172726.
  235. Heinrich R, Rapoport TA. Mathematical analysis of multienzyme systems. II. Steady state and transient control. Biosystems. 1975 Jul; 7(1):130-6. PMID: 125616.
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  236. Rapoport TA, Heinrich R. Mathematical analysis of multienzyme systems. I. Modelling of the glycolysis of human erythrocytes. Biosystems. 1975 Jul; 7(1):120-9. PMID: 168932.
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  237. Heinrich R, Rapoport TA. Mathematical analysis of multienzume systient control. Bio Systems. 1975; 7:130-136.
  238. Lukowsky A, Prehn S, Rapoport TA. Biosynthesis of proinsulin in islets of Langerhans of the carp (Cyprinus carpio). Biochim Biophys Acta. 1974 Aug 08; 359(2):248-52. PMID: 4604163.
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  239. Heinrich R, Rapoport TA. A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem. 1974 Feb 15; 42(1):89-95. PMID: 4830198.
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  240. Rapoport TA, Heinrich R, Jacobasch G, Rapoport S. A linear steady-state treatment of enzymatic chains. A mathematical model of glycolysis of human erythrocytes. Eur J Biochem. 1974 Feb 15; 42(1):107-20. PMID: 4364392.
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  241. Heinrich R, Rapoport TA. A linear steady-state treatment of enzymatic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector. Eur J Biochem. 1974 Feb 15; 42(1):97-105. PMID: 4830199.
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  242. Lukowsky A, Prehn S, Rapoport TA. Biosynthesis of proinsulin in islets of Langerhans of carp (Cyprinus carpio). Biochem Biophys Acta. 1974; 359:248-52.
  243. Heinrich R, Rapoport TA. The regulatory principles of the glycolysis of erythrocytes in vivo and in vitro. Symp Biol Hung. 1974; 18:173-212.
  244. Rapoport TA, Prehn S, Lukowsky A, Junghahn I. Biosynthesis of proinsulin of carp (Cyprinus carpio). Acta Biol Med Ger. 1974; 33(5-6):953-61. PMID: 4619956.
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  245. Rapoport TA, Prehn S, Lukowsky A, Junghahn I. Biosynthesis of proinsulin of carp (Cyrpinus carpio). Acta Biol Med Germ. 1974; 33:953-61.
  246. Rapoport SM, Rapoport TA, Heinrich R. The regulation of glycolysis in erythrocytes. 9th FEBS meeting Budapest, Publ. House Hung. Acad. Sci. 1974; 195-209.
  247. Höhne WE, Rapoport TA. Slow conformational changes of the inorganic pyrophosphatase from bakers' yeast induced by divalent metal ions. Eur J Biochem. 1973 Mar 01; 33(2):323-31. PMID: 4348444.
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  248. Rapoport TA, Höhne WE, Heitmann P, Rapoport S. Binding of ligands to the inorganic pyrophosphatase of bakers' yeast. Eur J Biochem. 1973 Mar 01; 33(2):341-7. PMID: 4348445.
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  249. Heinrich R, Rapoport TA. Linear theory of enzymatic chains; its application for the analysis of the crossover theorem and of the glycolysis of human erythrocytes. Acta Biol Med Ger. 1973; 31(4):479-94. PMID: 4150081.
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  250. Heinrich R, Rapoport TA. On the theory of enzymatic systems with application to the glycolysis of erythrocutes. Abhandlg. d. AdW der DDR VII. Intern. Sympo. uber Struktur und Funktion der Erythozyten. 1973; 21-7.
  251. Rapoport TA, Höhne WE, Reich JG, Heitmann P, Rapoport SM. A kinetic model for the action of the inorganic pyrophosphatase from bakers' yeast. The activating influence of magnesium ions. Eur J Biochem. 1972 Mar 27; 26(2):237-46. PMID: 4558242.
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  252. Höhne WE, Rapoport, TA, Heitmann P. Eine automatische Apparatur zur Ermittlung der kinetischen Parameter enzymatischer reaktionen. Acta Biol Med Germ. 1972; 29:841-50.
  253. Höhne WE, Rapoport T, Heitmann P. [An automatic apparatus for the determination of kinetic parameters of enzymatic reactions]. Acta Biol Med Ger. 1972; 29(6):841-50. PMID: 4349525.
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