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Tom A. Rapoport, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL150520 (RAPOPORT, TOM A) Feb 15, 2020 - Jan 21, 2024
    NIH
    Function and application of lung surfactant proteins
    Role: Principal Investigator
  2. P41RR015301 (EALICK, STEVEN E) Jun 15, 2001 - Mar 31, 2013
    NIH/NCRR
    An Undulator Resource for Structural Biology
    Role: Co-Principal Investigator
  3. R01GM054238 (RAPOPORT, TOM A) May 1, 1996 - Apr 30, 2004
    NIH
    POSTTRANSLATIONAL PROTEIN TRANSPORT INTO YEAST ER
    Role: Principal Investigator
  4. R01GM052586 (RAPOPORT, TOM A) May 1, 1995 - Feb 28, 2023
    NIH
    Protein Transport Across Membranes
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wu X, Rapoport TA. Translocation of Proteins through a Distorted Lipid Bilayer. Trends Cell Biol. 2021 Jan 30. PMID: 33531207.
    Citations: 1     Fields:    
  2. Wang N, Clark LD, Gao Y, Kozlov MM, Shemesh T, Rapoport TA. Mechanism of membrane-curvature generation by ER-tubule shaping proteins. Nat Commun. 2021 01 25; 12(1):568. PMID: 33495454.
    Citations:    Fields:    Translation:AnimalsCells
  3. Sever N, Milicic G, Bodnar NO, Wu X, Rapoport TA. Mechanism of Lamellar Body Formation by Lung Surfactant Protein B. Mol Cell. 2021 01 07; 81(1):49-66.e8. PMID: 33242393.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Catipovic MA, Rapoport TA. Protease protection assays show polypeptide movement into the SecY channel by power strokes of the SecA ATPase. EMBO Rep. 2020 11 05; 21(11):e50905. PMID: 32969592.
    Citations: 3     Fields:    
  5. Wu X, Siggel M, Ovchinnikov S, Mi W, Svetlov V, Nudler E, Liao M, Hummer G, Rapoport TA. Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex. Science. 2020 04 24; 368(6489). PMID: 32327568.
    Citations: 13     Fields:    Translation:Cells
  6. Yip MCJ, Bodnar NO, Rapoport TA. Ddi1 is a ubiquitin-dependent protease. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7776-7781. PMID: 32193351.
    Citations: 12     Fields:    Translation:AnimalsCells
  7. Peterson BG, Glaser ML, Rapoport TA, Baldridge RD. Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1. Elife. 2019 11 12; 8. PMID: 31713515.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Ma C, Wu X, Sun D, Park E, Catipovic MA, Rapoport TA, Gao N, Li L. Structure of the substrate-engaged SecA-SecY protein translocation machine. Nat Commun. 2019 06 28; 10(1):2872. PMID: 31253804.
    Citations: 10     Fields:    Translation:Cells
  9. Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science. 2019 08 02; 365(6452). PMID: 31249135.
    Citations: 36     Fields:    Translation:Cells
  10. Romano FB, Blok NB, Rapoport TA. Peroxisome protein import recapitulated in Xenopus egg extracts. J Cell Biol. 2019 06 03; 218(6):2021-2034. PMID: 30971414.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Catipovic MA, Bauer BW, Loparo JJ, Rapoport TA. Protein translocation by the SecA ATPase occurs by a power-stroke mechanism. EMBO J. 2019 05 02; 38(9). PMID: 30877095.
    Citations: 10     Fields:    Translation:Cells
  12. Wang S, Romano FB, Rapoport TA. Endoplasmic Reticulum Network Formation with Xenopus Egg Extracts. Cold Spring Harb Protoc. 2019 02 01; 2019(2). PMID: 29475993.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Wang N, Rapoport TA. Reconstituting the reticular ER network - mechanistic implications and open questions. J Cell Sci. 2019 01 22; 132(4). PMID: 30670475.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  14. Wu X, Cabanos C, Rapoport TA. Structure of the post-translational protein translocation machinery of the ER membrane. Nature. 2019 02; 566(7742):136-139. PMID: 30644436.
    Citations: 16     Fields:    Translation:AnimalsCells
  15. Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA. Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nat Struct Mol Biol. 2018 07; 25(7):616-622. PMID: 29967539.
    Citations: 19     Fields:    Translation:AnimalsCells
  16. Wu X, Rapoport TA. Mechanistic insights into ER-associated protein degradation. Curr Opin Cell Biol. 2018 08; 53:22-28. PMID: 29719269.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  17. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. J Biol Chem. 2018 04 06; 293(14):5360-5373. PMID: 29462788.
    Citations: 6     Fields:    Translation:Cells
  18. Wang S, Powers RE, Gold VA, Rapoport TA. The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discs. Life Sci Alliance. 2018 Jan; 1(1):e201700014. PMID: 30456344.
    Citations: 4     Fields:    
  19. Bodnar N, Rapoport T. Toward an understanding of the Cdc48/p97 ATPase. F1000Res. 2017; 6:1318. PMID: 28815021.
    Citations: 33     Fields:    
  20. Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature. 2017 08 17; 548(7667):352-355. PMID: 28682307.
    Citations: 53     Fields:    Translation:AnimalsCells
  21. Rapoport TA, Li L, Park E. Structural and Mechanistic Insights into Protein Translocation. Annu Rev Cell Dev Biol. 2017 10 06; 33:369-390. PMID: 28564553.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  22. Bodnar NO, Rapoport TA. Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. Cell. 2017 05 04; 169(4):722-735.e9. PMID: 28475898.
    Citations: 63     Fields:    Translation:AnimalsCells
  23. Tripathi A, Mandon EC, Gilmore R, Rapoport TA. Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins. J Biol Chem. 2017 05 12; 292(19):8007-8018. PMID: 28286332.
    Citations: 13     Fields:    Translation:AnimalsCells
  24. Powers RE, Wang S, Liu TY, Rapoport TA. Reconstitution of the tubular endoplasmic reticulum network with purified components. Nature. 2017 03 09; 543(7644):257-260. PMID: 28225760.
    Citations: 29     Fields:    Translation:AnimalsCells
  25. Wang S, Tukachinsky H, Romano FB, Rapoport TA. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife. 2016 09 13; 5. PMID: 27619977.
    Citations: 41     Fields:    Translation:AnimalsCells
  26. Baldridge RD, Rapoport TA. Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD. Cell. 2016 Jul 14; 166(2):394-407. PMID: 27321670.
    Citations: 62     Fields:    Translation:AnimalsCells
  27. Hu J, Rapoport TA. Fusion of the endoplasmic reticulum by membrane-bound GTPases. Semin Cell Dev Biol. 2016 12; 60:105-111. PMID: 27269373.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  28. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
    Citations: 53     Fields:    
  29. Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA. Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature. 2016 Mar 17; 531(7594):395-399. PMID: 26950603.
    Citations: 45     Fields:    Translation:Cells
  30. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1190-9. PMID: 26884191.
    Citations: 18     Fields:    Translation:Cells
  31. Tan D, Blok NB, Rapoport TA, Walz T. Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis. FEBS J. 2016 Mar; 283(6):986-92. PMID: 26476099.
    Citations: 6     Fields:    Translation:HumansCells
  32. Junker M, Rapoport TA. Involvement of VAT-1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria. Traffic. 2015 Dec; 16(12):1306-17. PMID: 26394711.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. Blok NB, Tan D, Wang RY, Penczek PA, Baker D, DiMaio F, Rapoport TA, Walz T. Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4017-25. PMID: 26170309.
    Citations: 27     Fields:    Translation:AnimalsCells
  34. Chen Y, Bauer BW, Rapoport TA, Gumbart JC. Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol. 2015 Jul 17; 427(14):2348-59. PMID: 25982945.
    Citations: 10     Fields:    Translation:Cells
  35. Liu TY, Bian X, Romano FB, Shemesh T, Rapoport TA, Hu J. Cis and trans interactions between atlastin molecules during membrane fusion. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1851-60. PMID: 25825753.
    Citations: 30     Fields:    Translation:AnimalsCells
  36. Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D. Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon. J Cell Sci. 2015 Mar 15; 128(6):1217-29. PMID: 25616894.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  37. Shemesh T, Klemm RW, Romano FB, Wang S, Vaughan J, Zhuang X, Tukachinsky H, Kozlov MM, Rapoport TA. A model for the generation and interconversion of ER morphologies. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):E5243-51. PMID: 25404289.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  38. Stein A, Ruggiano A, Carvalho P, Rapoport TA. Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell. 2014 Sep 11; 158(6):1375-1388. PMID: 25215493.
    Citations: 69     Fields:    Translation:AnimalsCells
  39. Bauer BW, Shemesh T, Chen Y, Rapoport TA. A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase. Cell. 2014 Jun 05; 157(6):1416-1429. PMID: 24906156.
    Citations: 44     Fields:    Translation:Cells
  40. Markgraf DF, Klemm RW, Junker M, Hannibal-Bach HK, Ejsing CS, Rapoport TA. An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Cell Rep. 2014 Jan 16; 6(1):44-55. PMID: 24373967.
    Citations: 33     Fields:    Translation:AnimalsCells
  41. Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013 Dec 09; 203(5):801-14. PMID: 24297752.
    Citations: 32     Fields:    Translation:AnimalsCells
  42. Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW. Structure of the SecY channel during initiation of protein translocation. Nature. 2014 Feb 06; 506(7486):102-6. PMID: 24153188.
    Citations: 61     Fields:    Translation:Cells
  43. Li L, Fierer JO, Rapoport TA, Howarth M. Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag. J Mol Biol. 2014 Jan 23; 426(2):309-17. PMID: 24161952.
    Citations: 57     Fields:    Translation:Cells
  44. Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell. 2013 Jul 18; 154(2):285-96. PMID: 23870120.
    Citations: 62     Fields:    Translation:AnimalsCells
  45. Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75. PMID: 23684613.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  46. Park E, Rapoport TA. Bacterial protein translocation requires only one copy of the SecY complex in vivo. J Cell Biol. 2012 Sep 03; 198(5):881-93. PMID: 22927464.
    Citations: 27     Fields:    Translation:Cells
  47. Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J. Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):E2146-54. PMID: 22802620.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  48. Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA. The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol. 2012 Apr 16; 197(2):209-17. PMID: 22508509.
    Citations: 53     Fields:    Translation:AnimalsCells
  49. Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012 Jun; 13(6):880-90. PMID: 22409400.
    Citations: 60     Fields:    Translation:AnimalsCells
  50. Park E, Rapoport TA. Mechanisms of Sec61/SecY-mediated protein translocation across membranes. Annu Rev Biophys. 2012; 41:21-40. PMID: 22224601.
    Citations: 150     Fields:    Translation:AnimalsCells
  51. Hu J, Prinz WA, Rapoport TA. Weaving the web of ER tubules. Cell. 2011 Dec 09; 147(6):1226-31. PMID: 22153070.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  52. Park E, Rapoport TA. Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature. 2011 May 12; 473(7346):239-42. PMID: 21562565.
    Citations: 41     Fields:    Translation:Cells
  53. Stanley AM, Carvalho P, Rapoport T. Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking. FEBS Lett. 2011 May 06; 585(9):1281-6. PMID: 21486563.
    Citations: 12     Fields:    Translation:AnimalsCells
  54. Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 07; 192(5):825-38. PMID: 21357747.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  55. Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):3976-81. PMID: 21368113.
    Citations: 100     Fields:    Translation:HumansCells
  56. Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA. Mechanisms determining the morphology of the peripheral ER. Cell. 2010 Nov 24; 143(5):774-88. PMID: 21111237.
    Citations: 167     Fields:    Translation:AnimalsCells
  57. Rapoport TA. A preliminary report on my life in science. Mol Biol Cell. 2010 Nov 15; 21(22):3770-2. PMID: 21079005.
    Citations:    Fields:    
  58. Carvalho P, Stanley AM, Rapoport TA. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell. 2010 Nov 12; 143(4):579-91. PMID: 21074049.
    Citations: 139     Fields:    Translation:AnimalsCells
  59. Schulman S, Wang B, Li W, Rapoport TA. Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15027-32. PMID: 20696932.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  60. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12. PMID: 20110994.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  61. Bauer BW, Rapoport TA. Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20800-5. PMID: 19933328.
    Citations: 30     Fields:    Translation:Cells
  62. Zimmer J, Rapoport TA. Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol. 2009 Dec 11; 394(4):606-12. PMID: 19850053.
    Citations: 29     Fields:    Translation:Cells
  63. Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell. 2009 Aug 07; 138(3):549-61. PMID: 19665976.
    Citations: 224     Fields:    Translation:AnimalsCells
  64. Shibata Y, Hu J, Kozlov MM, Rapoport TA. Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol. 2009; 25:329-54. PMID: 19575675.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  65. Zimmer J, Nam Y, Rapoport TA. Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature. 2008 Oct 16; 455(7215):936-43. PMID: 18923516.
    Citations: 206     Fields:    Translation:Cells
  66. Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA. A role for the two-helix finger of the SecA ATPase in protein translocation. Nature. 2008 Oct 16; 455(7215):984-7. PMID: 18923526.
    Citations: 63     Fields:    Translation:Cells
  67. Rapoport TA. Protein transport across the endoplasmic reticulum membrane. FEBS J. 2008 Sep; 275(18):4471-8. PMID: 18671729.
    Citations: 10     Fields:    Translation:Cells
  68. Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW. Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure. 2008 Jul; 16(7):1126-37. PMID: 18611385.
    Citations: 38     Fields:    Translation:AnimalsCells
  69. Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem. 2008 Jul 04; 283(27):18892-904. PMID: 18442980.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  70. Goder V, Carvalho P, Rapoport TA. The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett. 2008 May 14; 582(11):1575-80. PMID: 18407841.
    Citations: 18     Fields:    Translation:AnimalsCells
  71. Erlandson KJ, Or E, Osborne AR, Rapoport TA. Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem. 2008 Jun 06; 283(23):15709-15. PMID: 18359943.
    Citations: 21     Fields:    Translation:Cells
  72. Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science. 2008 Feb 29; 319(5867):1247-50. PMID: 18309084.
    Citations: 189     Fields:    Translation:AnimalsCells
  73. Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW. Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell. 2007 Dec 28; 28(6):1083-92. PMID: 18158904.
    Citations: 46     Fields:    Translation:Cells
  74. Burton BM, Marquis KA, Sullivan NL, Rapoport TA, Rudner DZ. The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell. 2007 Dec 28; 131(7):1301-12. PMID: 18160039.
    Citations: 63     Fields:    Translation:Cells
  75. Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA. The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol. 2007 Dec; 5(12):e322. PMID: 18052610.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  76. Rapoport TA. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature. 2007 Nov 29; 450(7170):663-9. PMID: 18046402.
    Citations: 316     Fields:    Translation:Cells
  77. Ye J, Cho SH, Fuselier J, Li W, Beckwith J, Rapoport TA. Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem. 2007 Nov 30; 282(48):34945-51. PMID: 17913712.
    Citations: 6     Fields:    Translation:Cells
  78. Saparov SM, Erlandson K, Cannon K, Schaletzky J, Schulman S, Rapoport TA, Pohl P. Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell. 2007 May 25; 26(4):501-9. PMID: 17531809.
    Citations: 36     Fields:    Translation:Cells
  79. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21. PMID: 17531810.
    Citations: 48     Fields:    Translation:Cells
  80. Or E, Rapoport T. Cross-linked SecA dimers are not functional in protein translocation. FEBS Lett. 2007 Jun 12; 581(14):2616-20. PMID: 17511989.
    Citations: 11     Fields:    Translation:Cells
  81. Osborne AR, Rapoport TA. Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell. 2007 Apr 06; 129(1):97-110. PMID: 17418789.
    Citations: 68     Fields:    Translation:Cells
  82. Zimmer J, Li W, Rapoport TA. A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol. 2006 Dec 01; 364(3):259-65. PMID: 16989859.
    Citations: 36     Fields:    Translation:Cells
  83. Shibata Y, Voeltz GK, Rapoport TA. Rough sheets and smooth tubules. Cell. 2006 Aug 11; 126(3):435-9. PMID: 16901774.
    Citations: 151     Fields:    Translation:HumansAnimalsCells
  84. Carvalho P, Goder V, Rapoport TA. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell. 2006 Jul 28; 126(2):361-73. PMID: 16873066.
    Citations: 326     Fields:    Translation:AnimalsCells
  85. Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11589-94. PMID: 16868077.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  86. Schaletzky J, Rapoport TA. Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane. Mol Biol Cell. 2006 Sep; 17(9):3860-9. PMID: 16822833.
    Citations: 19     Fields:    Translation:AnimalsCells
  87. Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell. 2006 Feb 10; 124(3):573-86. PMID: 16469703.
    Citations: 456     Fields:    Translation:HumansAnimalsCells
  88. Rapoport TA. Protein transport in and out of the endoplasmic reticulum. Harvey Lect. 2006-2007; 102:51-72. PMID: 20166563.
    Citations:    Fields:    Translation:Cells
  89. Ye Y, Shibata Y, Kikkert M, van Voorden S, Wiertz E, Rapoport TA. Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A. 2005 Oct 04; 102(40):14132-8. PMID: 16186510.
    Citations: 149     Fields:    Translation:HumansCells
  90. Kothe M, Ye Y, Wagner JS, De Luca HE, Kern E, Rapoport TA, Lencer WI. Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem. 2005 Jul 29; 280(30):28127-32. PMID: 15932873.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  91. Ménétret JF, Hegde RS, Heinrich SU, Chandramouli P, Ludtke SJ, Rapoport TA, Akey CW. Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol. 2005 Apr 29; 348(2):445-57. PMID: 15811380.
    Citations: 45     Fields:    Translation:AnimalsCells
  92. Cannon KS, Or E, Clemons WM, Shibata Y, Rapoport TA. Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol. 2005 Apr 25; 169(2):219-25. PMID: 15851514.
    Citations: 71     Fields:    Translation:Cells
  93. Heinrich R, Rapoport TA. Generation of nonidentical compartments in vesicular transport systems. J Cell Biol. 2005 Jan 17; 168(2):271-80. PMID: 15657397.
    Citations: 27     Fields:    Translation:Cells
  94. Osborne AR, Rapoport TA, van den Berg B. Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol. 2005; 21:529-50. PMID: 16212506.
    Citations: 132     Fields:    Translation:AnimalsCells
  95. Or E, Boyd D, Gon S, Beckwith J, Rapoport T. The bacterial ATPase SecA functions as a monomer in protein translocation. J Biol Chem. 2005 Mar 11; 280(10):9097-105. PMID: 15618215.
    Citations: 43     Fields:    Translation:Cells
  96. Ye J, Osborne AR, Groll M, Rapoport TA. RecA-like motor ATPases--lessons from structures. Biochim Biophys Acta. 2004 Nov 04; 1659(1):1-18. PMID: 15511523.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  97. Rapoport TA, Goder V, Heinrich SU, Matlack KE. Membrane-protein integration and the role of the translocation channel. Trends Cell Biol. 2004 Oct; 14(10):568-75. PMID: 15450979.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  98. Clemons WM, Ménétret JF, Akey CW, Rapoport TA. Structural insight into the protein translocation channel. Curr Opin Struct Biol. 2004 Aug; 14(4):390-6. PMID: 15313231.
    Citations: 14     Fields:    Translation:Cells
  99. Osborne AR, Clemons WM, Rapoport TA. A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):10937-42. PMID: 15256599.
    Citations: 59     Fields:    Translation:Cells
  100. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 2004 Jun 24; 429(6994):841-7. PMID: 15215856.
    Citations: 372     Fields:    Translation:HumansAnimalsCells
  101. van den Berg B, Black PN, Clemons WM, Rapoport TA. Crystal structure of the long-chain fatty acid transporter FadL. Science. 2004 Jun 04; 304(5676):1506-9. PMID: 15178802.
    Citations: 64     Fields:    Translation:Cells
  102. Van den Berg B, Clemons WM, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA. X-ray structure of a protein-conducting channel. Nature. 2004 Jan 01; 427(6969):36-44. PMID: 14661030.
    Citations: 456     Fields:    Translation:Cells
  103. Plath K, Wilkinson BM, Stirling CJ, Rapoport TA. Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell. 2004 Jan; 15(1):1-10. PMID: 14617809.
    Citations: 19     Fields:    Translation:AnimalsCells
  104. Le Gall S, Neuhof A, Rapoport T. The endoplasmic reticulum membrane is permeable to small molecules. Mol Biol Cell. 2004 Feb; 15(2):447-55. PMID: 14617815.
    Citations: 36     Fields:    Translation:HumansCells
  105. Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI. Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell. 2003 Dec; 14(12):4783-93. PMID: 13679513.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  106. Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA. Gangliosides are receptors for murine polyoma virus and SV40. EMBO J. 2003 Sep 01; 22(17):4346-55. PMID: 12941687.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  107. Heinrich SU, Rapoport TA. Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J. 2003 Jul 15; 22(14):3654-63. PMID: 12853480.
    Citations: 35     Fields:    Translation:Cells
  108. Ye Y, Meyer HH, Rapoport TA. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol. 2003 Jul 07; 162(1):71-84. PMID: 12847084.
    Citations: 240     Fields:    Translation:AnimalsCells
  109. Flierman D, Ye Y, Dai M, Chau V, Rapoport TA. Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. J Biol Chem. 2003 Sep 12; 278(37):34774-82. PMID: 12813030.
    Citations: 39     Fields:    Translation:AnimalsCells
  110. Morgan DG, Ménétret JF, Neuhof A, Rapoport TA, Akey CW. Structure of the mammalian ribosome-channel complex at 17A resolution. J Mol Biol. 2002 Dec 06; 324(4):871-86. PMID: 12460584.
    Citations: 31     Fields:    Translation:AnimalsCells
  111. Rodighiero C, Tsai B, Rapoport TA, Lencer WI. Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. . 2002 Dec; 3(12):1222-7. PMID: 12446567.
    Citations: 65     Translation:Cells
  112. Tsai B, Rapoport TA. Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1. J Cell Biol. 2002 Oct 28; 159(2):207-16. PMID: 12403808.
    Citations: 59     Fields:    Translation:AnimalsCells
  113. Voeltz GK, Rolls MM, Rapoport TA. Structural organization of the endoplasmic reticulum. . 2002 Oct; 3(10):944-50. PMID: 12370207.
    Citations: 158     Translation:HumansAnimalsCells
  114. Or E, Navon A, Rapoport T. Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane. EMBO J. 2002 Sep 02; 21(17):4470-9. PMID: