Harvard Catalyst Profiles

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Tom A. Rapoport, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL150520 (RAPOPORT, TOM A) Feb 15, 2020 - Jan 21, 2024
    NIH
    Function and application of lung surfactant proteins
    Role: Principal Investigator
  2. P41RR015301 (EALICK, STEVEN E) Jun 15, 2001 - Mar 31, 2013
    NIH/NCRR
    An Undulator Resource for Structural Biology
    Role: Co-Principal Investigator
  3. R01GM054238 (RAPOPORT, TOM A) May 1, 1996 - Apr 30, 2004
    NIH
    POSTTRANSLATIONAL PROTEIN TRANSPORT INTO YEAST ER
    Role: Principal Investigator
  4. R01GM052586 (RAPOPORT, TOM A) May 1, 1995 - Feb 28, 2023
    NIH
    Protein Transport Across Membranes
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gao Y, Skowyra ML, Feng P, Rapoport TA. Protein import into peroxisomes occurs through a nuclear pore-like phase. Science. 2022 12 16; 378(6625):eadf3971. PMID: 36520918; PMCID: PMC9795577.
    Citations: 1     Fields:    Translation:HumansCells
  2. Feng P, Skowyra ML, Rapoport TA. Structure and function of the peroxisomal ubiquitin ligase complex. Biochem Soc Trans. 2022 12 16; 50(6):1921-1930. PMID: 36421406.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Pisa R, Rapoport TA. Disulfide-crosslink analysis of the ubiquitin ligase Hrd1 complex during endoplasmic reticulum-associated protein degradation. J Biol Chem. 2022 09; 298(9):102373. PMID: 35970394; PMCID: PMC9478403.
    Citations:    Fields:    Translation:AnimalsCells
  4. Skowyra ML, Rapoport TA. PEX5 translocation into and out of peroxisomes drives matrix protein import. Mol Cell. 2022 09 01; 82(17):3209-3225.e7. PMID: 35931083; PMCID: PMC9444985.
    Citations: 2     Fields:    Translation:HumansCells
  5. Feng P, Wu X, Erramilli SK, Paulo JA, Knejski P, Gygi SP, Kossiakoff AA, Rapoport TA. A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel. Nature. 2022 07; 607(7918):374-380. PMID: 35768507; PMCID: PMC9279156.
    Citations:    Fields:    Translation:HumansCells
  6. Ji Z, Li H, Peterle D, Paulo JA, Ficarro SB, Wales TE, Marto JA, Gygi SP, Engen JR, Rapoport TA. Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase. Mol Cell. 2022 02 03; 82(3):570-584.e8. PMID: 34951965; PMCID: PMC8818041.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Wu X, Rapoport TA. Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). Proc Natl Acad Sci U S A. 2021 10 12; 118(41). PMID: 34620716.
    Citations: 5     Fields:    Translation:HumansCells
  8. Wu X, Rapoport TA. Translocation of Proteins through a Distorted Lipid Bilayer. Trends Cell Biol. 2021 06; 31(6):473-484. PMID: 33531207; PMCID: PMC8122044.
    Citations: 7     Fields:    Translation:Cells
  9. Wang N, Clark LD, Gao Y, Kozlov MM, Shemesh T, Rapoport TA. Mechanism of membrane-curvature generation by ER-tubule shaping proteins. Nat Commun. 2021 01 25; 12(1):568. PMID: 33495454.
    Citations: 8     Fields:    Translation:AnimalsCells
  10. Sever N, Milicic G, Bodnar NO, Wu X, Rapoport TA. Mechanism of Lamellar Body Formation by Lung Surfactant Protein B. Mol Cell. 2021 01 07; 81(1):49-66.e8. PMID: 33242393; PMCID: PMC7797001.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  11. Catipovic MA, Rapoport TA. Protease protection assays show polypeptide movement into the SecY channel by power strokes of the SecA ATPase. EMBO Rep. 2020 11 05; 21(11):e50905. PMID: 32969592.
    Citations: 5     Fields:    
  12. Wu X, Siggel M, Ovchinnikov S, Mi W, Svetlov V, Nudler E, Liao M, Hummer G, Rapoport TA. Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex. Science. 2020 04 24; 368(6489). PMID: 32327568; PMCID: PMC7380553.
    Citations: 39     Fields:    Translation:Cells
  13. Yip MCJ, Bodnar NO, Rapoport TA. Ddi1 is a ubiquitin-dependent protease. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7776-7781. PMID: 32193351; PMCID: PMC7149228.
    Citations: 22     Fields:    Translation:AnimalsCells
  14. Peterson BG, Glaser ML, Rapoport TA, Baldridge RD. Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1. Elife. 2019 11 12; 8. PMID: 31713515; PMCID: PMC6914336.
    Citations: 9     Fields:    Translation:AnimalsCells
  15. Ma C, Wu X, Sun D, Park E, Catipovic MA, Rapoport TA, Gao N, Li L. Structure of the substrate-engaged SecA-SecY protein translocation machine. Nat Commun. 2019 06 28; 10(1):2872. PMID: 31253804.
    Citations: 17     Fields:    Translation:Cells
  16. Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science. 2019 08 02; 365(6452). PMID: 31249135; PMCID: PMC6980381.
    Citations: 72     Fields:    Translation:Cells
  17. Romano FB, Blok NB, Rapoport TA. Peroxisome protein import recapitulated in Xenopus egg extracts. J Cell Biol. 2019 06 03; 218(6):2021-2034. PMID: 30971414.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Catipovic MA, Bauer BW, Loparo JJ, Rapoport TA. Protein translocation by the SecA ATPase occurs by a power-stroke mechanism. EMBO J. 2019 05 02; 38(9). PMID: 30877095; PMCID: PMC6484406.
    Citations: 14     Fields:    Translation:Cells
  19. Wang S, Romano FB, Rapoport TA. Endoplasmic Reticulum Network Formation with Xenopus Egg Extracts. Cold Spring Harb Protoc. 2019 02 01; 2019(2). PMID: 29475993.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Wang N, Rapoport TA. Reconstituting the reticular ER network - mechanistic implications and open questions. J Cell Sci. 2019 01 22; 132(4). PMID: 30670475.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  21. Wu X, Cabanos C, Rapoport TA. Structure of the post-translational protein translocation machinery of the ER membrane. Nature. 2019 02; 566(7742):136-139. PMID: 30644436; PMCID: PMC6367035.
    Citations: 40     Fields:    Translation:AnimalsCells
  22. Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA. Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nat Struct Mol Biol. 2018 07; 25(7):616-622. PMID: 29967539; PMCID: PMC6044470.
    Citations: 37     Fields:    Translation:AnimalsCells
  23. Wu X, Rapoport TA. Mechanistic insights into ER-associated protein degradation. Curr Opin Cell Biol. 2018 08; 53:22-28. PMID: 29719269; PMCID: PMC6131047.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  24. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. J Biol Chem. 2018 04 06; 293(14):5360-5373. PMID: 29462788.
    Citations: 8     Fields:    Translation:Cells
  25. Wang S, Powers RE, Gold VA, Rapoport TA. The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discs. Life Sci Alliance. 2018 Jan; 1(1):e201700014. PMID: 30456344.
    Citations: 5     Fields:    
  26. Bodnar N, Rapoport T. Toward an understanding of the Cdc48/p97 ATPase. F1000Res. 2017; 6:1318. PMID: 28815021.
    Citations: 54     Fields:    
  27. Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature. 2017 08 17; 548(7667):352-355. PMID: 28682307; PMCID: PMC5736104.
    Citations: 75     Fields:    Translation:AnimalsCells
  28. Rapoport TA, Li L, Park E. Structural and Mechanistic Insights into Protein Translocation. Annu Rev Cell Dev Biol. 2017 10 06; 33:369-390. PMID: 28564553.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  29. Bodnar NO, Rapoport TA. Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. Cell. 2017 05 04; 169(4):722-735.e9. PMID: 28475898; PMCID: PMC5751438.
    Citations: 106     Fields:    Translation:AnimalsCells
  30. Tripathi A, Mandon EC, Gilmore R, Rapoport TA. Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins. J Biol Chem. 2017 05 12; 292(19):8007-8018. PMID: 28286332.
    Citations: 19     Fields:    Translation:AnimalsCells
  31. Powers RE, Wang S, Liu TY, Rapoport TA. Reconstitution of the tubular endoplasmic reticulum network with purified components. Nature. 2017 03 09; 543(7644):257-260. PMID: 28225760.
    Citations: 38     Fields:    Translation:AnimalsCells
  32. Wang S, Tukachinsky H, Romano FB, Rapoport TA. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife. 2016 09 13; 5. PMID: 27619977.
    Citations: 65     Fields:    Translation:AnimalsCells
  33. Baldridge RD, Rapoport TA. Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD. Cell. 2016 Jul 14; 166(2):394-407. PMID: 27321670; PMCID: PMC4946995.
    Citations: 85     Fields:    Translation:AnimalsCells
  34. Hu J, Rapoport TA. Fusion of the endoplasmic reticulum by membrane-bound GTPases. Semin Cell Dev Biol. 2016 12; 60:105-111. PMID: 27269373.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  35. Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA. Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature. 2016 Mar 17; 531(7594):395-399. PMID: 26950603; PMCID: PMC4855518.
    Citations: 67     Fields:    Translation:Cells
  36. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
    Citations: 68     Fields:    
  37. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1190-9. PMID: 26884191; PMCID: PMC4780648.
    Citations: 19     Fields:    Translation:Cells
  38. Tan D, Blok NB, Rapoport TA, Walz T. Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis. FEBS J. 2016 Mar; 283(6):986-92. PMID: 26476099; PMCID: PMC4803591.
    Citations: 8     Fields:    Translation:HumansCells
  39. Junker M, Rapoport TA. Involvement of VAT-1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria. Traffic. 2015 Dec; 16(12):1306-17. PMID: 26394711.
    Citations: 5     Fields:    Translation:AnimalsCells
  40. Blok NB, Tan D, Wang RY, Penczek PA, Baker D, DiMaio F, Rapoport TA, Walz T. Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4017-25. PMID: 26170309; PMCID: PMC4522808.
    Citations: 36     Fields:    Translation:AnimalsCells
  41. Chen Y, Bauer BW, Rapoport TA, Gumbart JC. Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol. 2015 Jul 17; 427(14):2348-59. PMID: 25982945; PMCID: PMC4472001.
    Citations: 12     Fields:    Translation:Cells
  42. Liu TY, Bian X, Romano FB, Shemesh T, Rapoport TA, Hu J. Cis and trans interactions between atlastin molecules during membrane fusion. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1851-60. PMID: 25825753; PMCID: PMC4403200.
    Citations: 34     Fields:    Translation:AnimalsCells
  43. Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D. Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon. J Cell Sci. 2015 Mar 15; 128(6):1217-29. PMID: 25616894; PMCID: PMC4359925.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  44. Shemesh T, Klemm RW, Romano FB, Wang S, Vaughan J, Zhuang X, Tukachinsky H, Kozlov MM, Rapoport TA. A model for the generation and interconversion of ER morphologies. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):E5243-51. PMID: 25404289; PMCID: PMC4267389.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  45. Stein A, Ruggiano A, Carvalho P, Rapoport TA. Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell. 2014 Sep 11; 158(6):1375-1388. PMID: 25215493; PMCID: PMC4163015.
    Citations: 91     Fields:    Translation:AnimalsCells
  46. Bauer BW, Shemesh T, Chen Y, Rapoport TA. A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase. Cell. 2014 Jun 05; 157(6):1416-1429. PMID: 24906156; PMCID: PMC4104599.
    Citations: 54     Fields:    Translation:Cells
  47. Markgraf DF, Klemm RW, Junker M, Hannibal-Bach HK, Ejsing CS, Rapoport TA. An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Cell Rep. 2014 Jan 16; 6(1):44-55. PMID: 24373967; PMCID: PMC3947819.
    Citations: 40     Fields:    Translation:AnimalsCells
  48. Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013 Dec 09; 203(5):801-14. PMID: 24297752.
    Citations: 43     Fields:    Translation:AnimalsCells
  49. Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW. Structure of the SecY channel during initiation of protein translocation. Nature. 2014 Feb 06; 506(7486):102-6. PMID: 24153188; PMCID: PMC3948209.
    Citations: 78     Fields:    Translation:Cells
  50. Li L, Fierer JO, Rapoport TA, Howarth M. Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag. J Mol Biol. 2014 Jan 23; 426(2):309-17. PMID: 24161952; PMCID: PMC3959856.
    Citations: 75     Fields:    Translation:Cells
  51. Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell. 2013 Jul 18; 154(2):285-96. PMID: 23870120; PMCID: PMC3767119.
    Citations: 83     Fields:    Translation:AnimalsCells
  52. Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75. PMID: 23684613.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  53. Park E, Rapoport TA. Bacterial protein translocation requires only one copy of the SecY complex in vivo. J Cell Biol. 2012 Sep 03; 198(5):881-93. PMID: 22927464.
    Citations: 29     Fields:    Translation:Cells
  54. Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J. Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):E2146-54. PMID: 22802620.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  55. Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA. The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol. 2012 Apr 16; 197(2):209-17. PMID: 22508509.
    Citations: 63     Fields:    Translation:AnimalsCells
  56. Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012 Jun; 13(6):880-90. PMID: 22409400.
    Citations: 69     Fields:    Translation:AnimalsCells
  57. Park E, Rapoport TA. Mechanisms of Sec61/SecY-mediated protein translocation across membranes. Annu Rev Biophys. 2012; 41:21-40. PMID: 22224601.
    Citations: 175     Fields:    Translation:AnimalsCells
  58. Hu J, Prinz WA, Rapoport TA. Weaving the web of ER tubules. Cell. 2011 Dec 09; 147(6):1226-31. PMID: 22153070.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  59. Park E, Rapoport TA. Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature. 2011 May 12; 473(7346):239-42. PMID: 21562565; PMCID: PMC3093665.
    Citations: 51     Fields:    Translation:Cells
  60. Stanley AM, Carvalho P, Rapoport T. Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking. FEBS Lett. 2011 May 06; 585(9):1281-6. PMID: 21486563.
    Citations: 13     Fields:    Translation:AnimalsCells
  61. Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 07; 192(5):825-38. PMID: 21357747.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  62. Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):3976-81. PMID: 21368113.
    Citations: 111     Fields:    Translation:HumansCells
  63. Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA. Mechanisms determining the morphology of the peripheral ER. Cell. 2010 Nov 24; 143(5):774-88. PMID: 21111237; PMCID: PMC3008339.
    Citations: 222     Fields:    Translation:AnimalsCells
  64. Rapoport TA. A preliminary report on my life in science. Mol Biol Cell. 2010 Nov 15; 21(22):3770-2. PMID: 21079005.
    Citations:    Fields:    
  65. Carvalho P, Stanley AM, Rapoport TA. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell. 2010 Nov 12; 143(4):579-91. PMID: 21074049; PMCID: PMC3026631.
    Citations: 164     Fields:    Translation:AnimalsCells
  66. Schulman S, Wang B, Li W, Rapoport TA. Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15027-32. PMID: 20696932.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  67. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12. PMID: 20110994.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  68. Bauer BW, Rapoport TA. Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20800-5. PMID: 19933328.
    Citations: 33     Fields:    Translation:Cells
  69. Zimmer J, Rapoport TA. Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol. 2009 Dec 11; 394(4):606-12. PMID: 19850053; PMCID: PMC2832196.
    Citations: 32     Fields:    Translation:Cells
  70. Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell. 2009 Aug 07; 138(3):549-61. PMID: 19665976; PMCID: PMC2746359.
    Citations: 265     Fields:    Translation:AnimalsCells
  71. Shibata Y, Hu J, Kozlov MM, Rapoport TA. Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol. 2009; 25:329-54. PMID: 19575675.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  72. Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA. A role for the two-helix finger of the SecA ATPase in protein translocation. Nature. 2008 Oct 16; 455(7215):984-7. PMID: 18923526; PMCID: PMC4354775.
    Citations: 68     Fields:    Translation:Cells
  73. Zimmer J, Nam Y, Rapoport TA. Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature. 2008 Oct 16; 455(7215):936-43. PMID: 18923516; PMCID: PMC7164768.
    Citations: 228     Fields:    Translation:Cells
  74. Rapoport TA. Protein transport across the endoplasmic reticulum membrane. FEBS J. 2008 Sep; 275(18):4471-8. PMID: 18671729.
    Citations: 12     Fields:    Translation:Cells
  75. Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW. Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure. 2008 Jul; 16(7):1126-37. PMID: 18611385.
    Citations: 44     Fields:    Translation:AnimalsCells
  76. Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem. 2008 Jul 04; 283(27):18892-904. PMID: 18442980.
    Citations: 179     Fields:    Translation:HumansAnimalsCells
  77. Goder V, Carvalho P, Rapoport TA. The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett. 2008 May 14; 582(11):1575-80. PMID: 18407841.
    Citations: 20     Fields:    Translation:AnimalsCells
  78. Erlandson KJ, Or E, Osborne AR, Rapoport TA. Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem. 2008 Jun 06; 283(23):15709-15. PMID: 18359943; PMCID: PMC2409214.
    Citations: 24     Fields:    Translation:Cells
  79. Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science. 2008 Feb 29; 319(5867):1247-50. PMID: 18309084.
    Citations: 226     Fields:    Translation:AnimalsCells
  80. Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW. Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell. 2007 Dec 28; 28(6):1083-92. PMID: 18158904.
    Citations: 51     Fields:    Translation:Cells
  81. Burton BM, Marquis KA, Sullivan NL, Rapoport TA, Rudner DZ. The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell. 2007 Dec 28; 131(7):1301-12. PMID: 18160039.
    Citations: 68     Fields:    Translation:Cells
  82. Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA. The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol. 2007 Dec; 5(12):e322. PMID: 18052610.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  83. Rapoport TA. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature. 2007 Nov 29; 450(7170):663-9. PMID: 18046402.
    Citations: 366     Fields:    Translation:Cells
  84. Ye J, Cho SH, Fuselier J, Li W, Beckwith J, Rapoport TA. Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem. 2007 Nov 30; 282(48):34945-51. PMID: 17913712.
    Citations: 7     Fields:    Translation:Cells
  85. Saparov SM, Erlandson K, Cannon K, Schaletzky J, Schulman S, Rapoport TA, Pohl P. Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell. 2007 May 25; 26(4):501-9. PMID: 17531809.
    Citations: 41     Fields:    Translation:Cells
  86. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21. PMID: 17531810.
    Citations: 54     Fields:    Translation:Cells
  87. Or E, Rapoport T. Cross-linked SecA dimers are not functional in protein translocation. FEBS Lett. 2007 Jun 12; 581(14):2616-20. PMID: 17511989; PMCID: PMC2755086.
    Citations: 11     Fields:    Translation:Cells
  88. Osborne AR, Rapoport TA. Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell. 2007 Apr 06; 129(1):97-110. PMID: 17418789.
    Citations: 71     Fields:    Translation:Cells
  89. Zimmer J, Li W, Rapoport TA. A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol. 2006 Dec 01; 364(3):259-65. PMID: 16989859.
    Citations: 41     Fields:    Translation:Cells
  90. Shibata Y, Voeltz GK, Rapoport TA. Rough sheets and smooth tubules. Cell. 2006 Aug 11; 126(3):435-9. PMID: 16901774.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
  91. Carvalho P, Goder V, Rapoport TA. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell. 2006 Jul 28; 126(2):361-73. PMID: 16873066.
    Citations: 362     Fields:    Translation:AnimalsCells
  92. Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11589-94. PMID: 16868077; PMCID: PMC1520313.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  93. Schaletzky J, Rapoport TA. Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane. Mol Biol Cell. 2006 Sep; 17(9):3860-9. PMID: 16822833; PMCID: PMC1593163.
    Citations: 19     Fields:    Translation:AnimalsCells
  94. Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell. 2006 Feb 10; 124(3):573-86. PMID: 16469703.
    Citations: 531     Fields:    Translation:HumansAnimalsCells