Harvard Catalyst Profiles

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Tom A. Rapoport, Ph.D.

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Research
research activities and funding
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  1. P41RR015301 (EALICK, STEVEN E) Jun 15, 2001 - Mar 31, 2013
    NIH/NCRR
    An Undulator Resource for Structural Biology
    Role: Co-Principal Investigator
  2. R01GM054238 (RAPOPORT, TOM A) May 1, 1996 - Apr 30, 2004
    NIH/NIGMS
    POSTTRANSLATIONAL PROTEIN TRANSPORT INTO YEAST ER
    Role: Principal Investigator
  3. R01GM052586 (RAPOPORT, TOM A) May 1, 1995 - Feb 28, 2023
    NIH/NIGMS
    Protein Transport Across Membranes
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ma C, Wu X, Sun D, Park E, Catipovic MA, Rapoport TA, Gao N, Li L. Structure of the substrate-engaged SecA-SecY protein translocation machine. Nat Commun. 2019 Jun 28; 10(1):2872. PMID: 31253804.
    Citations:    
  2. Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA. Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science. 2019 Jun 27. PMID: 31249135.
    Citations:    
  3. Romano FB, Blok NB, Rapoport TA. Peroxisome protein import recapitulated in Xenopus egg extracts. J Cell Biol. 2019 Jun 03; 218(6):2021-2034. PMID: 30971414.
    Citations:    
  4. Catipovic MA, Bauer BW, Loparo JJ, Rapoport TA. Protein translocation by the SecA ATPase occurs by a power-stroke mechanism. EMBO J. 2019 May 02; 38(9). PMID: 30877095.
    Citations:    
  5. Wang S, Romano FB, Rapoport TA. Endoplasmic Reticulum Network Formation with Xenopus Egg Extracts. Cold Spring Harb Protoc. 2019 Feb 01; 2019(2):pdb.prot097204. PMID: 29475993.
    Citations:    Fields:    
  6. Wang N, Rapoport TA. Reconstituting the reticular ER network - mechanistic implications and open questions. J Cell Sci. 2019 Jan 22; 132(4). PMID: 30670475.
    Citations:    Fields:    
  7. Wu X, Cabanos C, Rapoport TA. Structure of the post-translational protein translocation machinery of the ER membrane. Nature. 2019 02; 566(7742):136-139. PMID: 30644436.
    Citations:    Fields:    
  8. Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA. Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nat Struct Mol Biol. 2018 Jul; 25(7):616-622. PMID: 29967539.
    Citations:    Fields:    
  9. Wu X, Rapoport TA. Mechanistic insights into ER-associated protein degradation. Curr Opin Cell Biol. 2018 08; 53:22-28. PMID: 29719269.
    Citations: 2     Fields:    
  10. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA. Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii. J Biol Chem. 2018 04 06; 293(14):5360-5373. PMID: 29462788.
    Citations:    Fields:    Translation:Cells
  11. Wang S, Powers RE, Gold VA, Rapoport TA. The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discs. Life Sci Alliance. 2018 Jan; 1(1):e201700014. PMID: 30456344.
    Citations:    
  12. Bodnar N, Rapoport T. Toward an understanding of the Cdc48/p97 ATPase. F1000Res. 2017; 6:1318. PMID: 28815021.
    Citations: 3     
  13. Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature. 2017 08 17; 548(7667):352-355. PMID: 28682307.
    Citations: 9     Fields:    Translation:AnimalsCells
  14. Rapoport TA, Li L, Park E. Structural and Mechanistic Insights into Protein Translocation. Annu Rev Cell Dev Biol. 2017 10 06; 33:369-390. PMID: 28564553.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Bodnar NO, Rapoport TA. Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. Cell. 2017 05 04; 169(4):722-735.e9. PMID: 28475898.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Tripathi A, Mandon EC, Gilmore R, Rapoport TA. Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins. J Biol Chem. 2017 05 12; 292(19):8007-8018. PMID: 28286332.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Powers RE, Wang S, Liu TY, Rapoport TA. Reconstitution of the tubular endoplasmic reticulum network with purified components. Nature. 2017 03 09; 543(7644):257-260. PMID: 28225760.
    Citations: 6     Fields:    Translation:AnimalsCells
  18. Wang S, Tukachinsky H, Romano FB, Rapoport TA. Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife. 2016 09 13; 5. PMID: 27619977.
    Citations: 10     Fields:    Translation:AnimalsCells
  19. Baldridge RD, Rapoport TA. Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD. Cell. 2016 Jul 14; 166(2):394-407. PMID: 27321670.
    Citations: 23     Fields:    Translation:AnimalsCells
  20. Hu J, Rapoport TA. Fusion of the endoplasmic reticulum by membrane-bound GTPases. Semin Cell Dev Biol. 2016 12; 60:105-111. PMID: 27269373.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
    Citations: 24     Fields:    
  22. Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA. Crystal structure of a substrate-engaged SecY protein-translocation channel. Nature. 2016 Mar 17; 531(7594):395-399. PMID: 26950603.
    Citations: 18     Fields:    Translation:Cells
  23. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1190-9. PMID: 26884191.
    Citations: 4     Fields:    Translation:Cells
  24. Tan D, Blok NB, Rapoport TA, Walz T. Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis. FEBS J. 2016 Mar; 283(6):986-92. PMID: 26476099.
    Citations: 5     Fields:    Translation:HumansCells
  25. Junker M, Rapoport TA. Involvement of VAT-1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria. Traffic. 2015 Dec; 16(12):1306-17. PMID: 26394711.
    Citations: 1     Fields:    Translation:AnimalsCells
  26. Blok NB, Tan D, Wang RY, Penczek PA, Baker D, DiMaio F, Rapoport TA, Walz T. Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4017-25. PMID: 26170309.
    Citations: 19     Fields:    Translation:AnimalsCells
  27. Chen Y, Bauer BW, Rapoport TA, Gumbart JC. Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol. 2015 Jul 17; 427(14):2348-59. PMID: 25982945.
    Citations: 4     Fields:    Translation:Cells
  28. Liu TY, Bian X, Romano FB, Shemesh T, Rapoport TA, Hu J. Cis and trans interactions between atlastin molecules during membrane fusion. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1851-60. PMID: 25825753.
    Citations: 14     Fields:    Translation:AnimalsCells
  29. Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D. Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon. J Cell Sci. 2015 Mar 15; 128(6):1217-29. PMID: 25616894.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  30. Shemesh T, Klemm RW, Romano FB, Wang S, Vaughan J, Zhuang X, Tukachinsky H, Kozlov MM, Rapoport TA. A model for the generation and interconversion of ER morphologies. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):E5243-51. PMID: 25404289.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  31. Stein A, Ruggiano A, Carvalho P, Rapoport TA. Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell. 2014 Sep 11; 158(6):1375-1388. PMID: 25215493.
    Citations: 45     Fields:    Translation:AnimalsCells
  32. Bauer BW, Shemesh T, Chen Y, Rapoport TA. A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase. Cell. 2014 Jun 05; 157(6):1416-29. PMID: 24906156.
    Citations: 23     Fields:    Translation:Cells
  33. Markgraf DF, Klemm RW, Junker M, Hannibal-Bach HK, Ejsing CS, Rapoport TA. An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Cell Rep. 2014 Jan 16; 6(1):44-55. PMID: 24373967.
    Citations: 19     Fields:    Translation:AnimalsCells
  34. Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013 Dec 09; 203(5):801-14. PMID: 24297752.
    Citations: 18     Fields:    Translation:AnimalsCells
  35. Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW. Structure of the SecY channel during initiation of protein translocation. Nature. 2014 Feb 06; 506(7486):102-6. PMID: 24153188.
    Citations: 47     Fields:    Translation:Cells
  36. Li L, Fierer JO, Rapoport TA, Howarth M. Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag. J Mol Biol. 2014 Jan 23; 426(2):309-17. PMID: 24161952.
    Citations: 24     Fields:    Translation:Cells
  37. Terasaki M, Shemesh T, Kasthuri N, Klemm RW, Schalek R, Hayworth KJ, Hand AR, Yankova M, Huber G, Lichtman JW, Rapoport TA, Kozlov MM. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell. 2013 Jul 18; 154(2):285-96. PMID: 23870120.
    Citations: 33     Fields:    Translation:AnimalsCells
  38. Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY. A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep. 2013 May 30; 3(5):1465-75. PMID: 23684613.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  39. Park E, Rapoport TA. Bacterial protein translocation requires only one copy of the SecY complex in vivo. J Cell Biol. 2012 Sep 03; 198(5):881-93. PMID: 22927464.
    Citations: 21     Fields:    Translation:Cells
  40. Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J. Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):E2146-54. PMID: 22802620.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  41. Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA. The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol. 2012 Apr 16; 197(2):209-17. PMID: 22508509.
    Citations: 40     Fields:    Translation:AnimalsCells
  42. Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw JM. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic. 2012 Jun; 13(6):880-90. PMID: 22409400.
    Citations: 47     Fields:    Translation:AnimalsCells
  43. Park E, Rapoport TA. Mechanisms of Sec61/SecY-mediated protein translocation across membranes. Annu Rev Biophys. 2012; 41:21-40. PMID: 22224601.
    Citations: 111     Fields:    Translation:AnimalsCells
  44. Hu J, Prinz WA, Rapoport TA. Weaving the web of ER tubules. Cell. 2011 Dec 09; 147(6):1226-31. PMID: 22153070.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  45. Park E, Rapoport TA. Preserving the membrane barrier for small molecules during bacterial protein translocation. Nature. 2011 May 12; 473(7346):239-42. PMID: 21562565.
    Citations: 29     Fields:    Translation:Cells
  46. Stanley AM, Carvalho P, Rapoport T. Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking. FEBS Lett. 2011 May 06; 585(9):1281-6. PMID: 21486563.
    Citations: 10     Fields:    Translation:AnimalsCells
  47. Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 07; 192(5):825-38. PMID: 21357747.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  48. Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):3976-81. PMID: 21368113.
    Citations: 70     Fields:    Translation:HumansCells
  49. Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA. Mechanisms determining the morphology of the peripheral ER. Cell. 2010 Nov 24; 143(5):774-88. PMID: 21111237.
    Citations: 122     Fields:    Translation:AnimalsCells
  50. Rapoport TA. A preliminary report on my life in science. Mol Biol Cell. 2010 Nov 15; 21(22):3770-2. PMID: 21079005.
    Citations:    Fields:    
  51. Carvalho P, Stanley AM, Rapoport TA. Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell. 2010 Nov 12; 143(4):579-91. PMID: 21074049.
    Citations: 118     Fields:    Translation:AnimalsCells
  52. Schulman S, Wang B, Li W, Rapoport TA. Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15027-32. PMID: 20696932.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  53. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12. PMID: 20110994.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  54. Bauer BW, Rapoport TA. Mapping polypeptide interactions of the SecA ATPase during translocation. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20800-5. PMID: 19933328.
    Citations: 21     Fields:    Translation:Cells
  55. Zimmer J, Rapoport TA. Conformational flexibility and peptide interaction of the translocation ATPase SecA. J Mol Biol. 2009 Dec 11; 394(4):606-12. PMID: 19850053.
    Citations: 21     Fields:    Translation:Cells
  56. Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell. 2009 Aug 07; 138(3):549-61. PMID: 19665976.
    Citations: 171     Fields:    Translation:AnimalsCells
  57. Shibata Y, Hu J, Kozlov MM, Rapoport TA. Mechanisms shaping the membranes of cellular organelles. Annu Rev Cell Dev Biol. 2009; 25:329-54. PMID: 19575675.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  58. Zimmer J, Nam Y, Rapoport TA. Structure of a complex of the ATPase SecA and the protein-translocation channel. Nature. 2008 Oct 16; 455(7215):936-43. PMID: 18923516.
    Citations: 159     Fields:    Translation:Cells
  59. Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA. A role for the two-helix finger of the SecA ATPase in protein translocation. Nature. 2008 Oct 16; 455(7215):984-7. PMID: 18923526.
    Citations: 48     Fields:    Translation:Cells
  60. Rapoport TA. Protein transport across the endoplasmic reticulum membrane. FEBS J. 2008 Sep; 275(18):4471-8. PMID: 18671729.
    Citations: 8     Fields:    Translation:Cells
  61. Ménétret JF, Hegde RS, Aguiar M, Gygi SP, Park E, Rapoport TA, Akey CW. Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure. 2008 Jul; 16(7):1126-37. PMID: 18611385.
    Citations: 32     Fields:    Translation:AnimalsCells
  62. Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK. The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem. 2008 Jul 04; 283(27):18892-904. PMID: 18442980.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  63. Goder V, Carvalho P, Rapoport TA. The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p. FEBS Lett. 2008 May 14; 582(11):1575-80. PMID: 18407841.
    Citations: 13     Fields:    Translation:AnimalsCells
  64. Erlandson KJ, Or E, Osborne AR, Rapoport TA. Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem. 2008 Jun 06; 283(23):15709-15. PMID: 18359943.
    Citations: 11     Fields:    Translation:Cells
  65. Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA. Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science. 2008 Feb 29; 319(5867):1247-50. PMID: 18309084.
    Citations: 154     Fields:    Translation:AnimalsCells
  66. Ménétret JF, Schaletzky J, Clemons WM, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW. Ribosome binding of a single copy of the SecY complex: implications for protein translocation. Mol Cell. 2007 Dec 28; 28(6):1083-92. PMID: 18158904.
    Citations: 43     Fields:    Translation:Cells
  67. Burton BM, Marquis KA, Sullivan NL, Rapoport TA, Rudner DZ. The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis. Cell. 2007 Dec 28; 131(7):1301-12. PMID: 18160039.
    Citations: 56     Fields:    Translation:Cells
  68. Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA. The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol. 2007 Dec; 5(12):e322. PMID: 18052610.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  69. Rapoport TA. Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes. Nature. 2007 Nov 29; 450(7170):663-9. PMID: 18046402.
    Citations: 254     Fields:    Translation:Cells
  70. Ye J, Cho SH, Fuselier J, Li W, Beckwith J, Rapoport TA. Crystal structure of an unusual thioredoxin protein with a zinc finger domain. J Biol Chem. 2007 Nov 30; 282(48):34945-51. PMID: 17913712.
    Citations: 6     Fields:    Translation:Cells
  71. Saparov SM, Erlandson K, Cannon K, Schaletzky J, Schulman S, Rapoport TA, Pohl P. Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell. 2007 May 25; 26(4):501-9. PMID: 17531809.
    Citations: 28     Fields:    Translation:Cells
  72. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21. PMID: 17531810.
    Citations: 41     Fields:    Translation:Cells
  73. Or E, Rapoport T. Cross-linked SecA dimers are not functional in protein translocation. FEBS Lett. 2007 Jun 12; 581(14):2616-20. PMID: 17511989.
    Citations: 10     Fields:    Translation:Cells
  74. Osborne AR, Rapoport TA. Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell. 2007 Apr 06; 129(1):97-110. PMID: 17418789.
    Citations: 64     Fields:    Translation:Cells
  75. Zimmer J, Li W, Rapoport TA. A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol. 2006 Dec 01; 364(3):259-65. PMID: 16989859.
    Citations: 29     Fields:    Translation:Cells
  76. Shibata Y, Voeltz GK, Rapoport TA. Rough sheets and smooth tubules. Cell. 2006 Aug 11; 126(3):435-9. PMID: 16901774.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  77. Carvalho P, Goder V, Rapoport TA. Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell. 2006 Jul 28; 126(2):361-73. PMID: 16873066.
    Citations: 268     Fields:    Translation:AnimalsCells
  78. Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11589-94. PMID: 16868077.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  79. Schaletzky J, Rapoport TA. Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane. Mol Biol Cell. 2006 Sep; 17(9):3860-9. PMID: 16822833.
    Citations: 18     Fields:    Translation:AnimalsCells
  80. Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A class of membrane proteins shaping the tubular endoplasmic reticulum. Cell. 2006 Feb 10; 124(3):573-86. PMID: 16469703.
    Citations: 366     Fields:    Translation:HumansAnimalsCells
  81. Rapoport TA. Protein transport in and out of the endoplasmic reticulum. Harvey Lect. 2006-2007; 102:51-72. PMID: 20166563.
    Citations:    Fields:    Translation:Cells
  82. Ye Y, Shibata Y, Kikkert M, van Voorden S, Wiertz E, Rapoport TA. Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A. 2005 Oct 04; 102(40):14132-8. PMID: 16186510.
    Citations: 128     Fields:    Translation:HumansCells
  83. Kothe M, Ye Y, Wagner JS, De Luca HE, Kern E, Rapoport TA, Lencer WI. Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate. J Biol Chem. 2005 Jul 29; 280(30):28127-32. PMID: 15932873.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  84. Ménétret JF, Hegde RS, Heinrich SU, Chandramouli P, Ludtke SJ, Rapoport TA, Akey CW. Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol. 2005 Apr 29; 348(2):445-57. PMID: 15811380.
    Citations: 42     Fields:    Translation:AnimalsCells
  85. Cannon KS, Or E, Clemons WM, Shibata Y, Rapoport TA. Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY. J Cell Biol. 2005 Apr 25; 169(2):219-25. PMID: 15851514.
    Citations: 58     Fields:    Translation:Cells
  86. Heinrich R, Rapoport TA. Generation of nonidentical compartments in vesicular transport systems. J Cell Biol. 2005 Jan 17; 168(2):271-80. PMID: 15657397.
    Citations: 24     Fields:    Translation:Cells
  87. Osborne AR, Rapoport TA, van den Berg B. Protein translocation by the Sec61/SecY channel. Annu Rev Cell Dev Biol. 2005; 21:529-50. PMID: 16212506.
    Citations: 116     Fields:    Translation:AnimalsCells
  88. Or E, Boyd D, Gon S, Beckwith J, Rapoport T. The bacterial ATPase SecA functions as a monomer in protein translocation. J Biol Chem. 2005 Mar 11; 280(10):9097-105. PMID: 15618215.
    Citations: 38     Fields:    Translation:Cells
  89. Ye J, Osborne AR, Groll M, Rapoport TA. RecA-like motor ATPases--lessons from structures. Biochim Biophys Acta. 2004 Nov 04; 1659(1):1-18. PMID: 15511523.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  90. Rapoport TA, Goder V, Heinrich SU, Matlack KE. Membrane-protein integration and the role of the translocation channel. Trends Cell Biol. 2004 Oct; 14(10):568-75. PMID: 15450979.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  91. Clemons WM, Ménétret JF, Akey CW, Rapoport TA. Structural insight into the protein translocation channel. Curr Opin Struct Biol. 2004 Aug; 14(4):390-6. PMID: 15313231.
    Citations: 13     Fields:    Translation:Cells
  92. Osborne AR, Clemons WM, Rapoport TA. A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):10937-42. PMID: 15256599.
    Citations: 51     Fields:    Translation:Cells
  93. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature. 2004 Jun 24; 429(6994):841-7. PMID: 15215856.
    Citations: 321     Fields:    Translation:HumansAnimalsCells
  94. van den Berg B, Black PN, Clemons WM, Rapoport TA. Crystal structure of the long-chain fatty acid transporter FadL. Science. 2004 Jun 04; 304(5676):1506-9. PMID: 15178802.
    Citations: 45     Fields:    Translation:Cells
  95. Van den Berg B, Clemons WM, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA. X-ray structure of a protein-conducting channel. Nature. 2004 Jan 01; 427(6969):36-44. PMID: 14661030.
    Citations: 385     Fields:    Translation:Cells
  96. Plath K, Wilkinson BM, Stirling CJ, Rapoport TA. Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell. 2004 Jan; 15(1):1-10. PMID: 14617809.
    Citations: 15     Fields:    Translation:AnimalsCells
  97. Le Gall S, Neuhof A, Rapoport T. The endoplasmic reticulum membrane is permeable to small molecules. Mol Biol Cell. 2004 Feb; 15(2):447-55. PMID: 14617815.
    Citations: 31     Fields:    Translation:HumansCells
  98. Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI. Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell. 2003 Dec; 14(12):4783-93. PMID: 13679513.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  99. Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA. Gangliosides are receptors for murine polyoma virus and SV40. EMBO J. 2003 Sep 01; 22(17):4346-55. PMID: 12941687.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  100. Heinrich SU, Rapoport TA. Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane. EMBO J. 2003 Jul 15; 22(14):3654-63. PMID: 12853480.
    Citations: 32     Fields:    Translation:Cells
  101. Ye Y, Meyer HH, Rapoport TA. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol. 2003 Jul 07; 162(1):71-84. PMID: 12847084.
    Citations: 206     Fields:    Translation:AnimalsCells
  102. Flierman D, Ye Y, Dai M, Chau V, Rapoport TA. Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane. J Biol Chem. 2003 Sep 12; 278(37):34774-82. PMID: 12813030.
    Citations: 35     Fields:    Translation:AnimalsCells
  103. Morgan DG, Ménétret JF, Neuhof A, Rapoport TA, Akey CW. Structure of the mammalian ribosome-channel complex at 17A resolution. J Mol Biol. 2002 Dec 06; 324(4):871-86. PMID: 12460584.
    Citations: 31     Fields:    Translation:AnimalsCells
  104. Rodighiero C, Tsai B, Rapoport TA, Lencer WI. Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation. EMBO Rep. 2002 Dec; 3(12):1222-7. PMID: 12446567.
    Citations: 57     Fields:    Translation:Cells
  105. Tsai B, Rapoport TA. Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1. J Cell Biol. 2002 Oct 28; 159(2):207-16. PMID: 12403808.
    Citations: 56     Fields:    Translation:AnimalsCells
  106. Voeltz GK, Rolls MM, Rapoport TA. Structural organization of the endoplasmic reticulum. EMBO Rep. 2002 Oct; 3(10):944-50. PMID: 12370207.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  107. Or E, Navon A, Rapoport T. Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane. EMBO J. 2002 Sep 02; 21(17):4470-9. PMID: 12198149.
    Citations: 56     Fields:    Translation:Cells
  108. Stein PA, Toret CP, Salic AN, Rolls MM, Rapoport TA. A novel centrosome-associated protein with affinity for microtubules. J Cell Sci. 2002 Sep 01; 115(Pt 17):3389-402. PMID: 12154070.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  109. Breyton C, Haase W, Rapoport TA, Kühlbrandt W, Collinson I. Three-dimensional structure of the bacterial protein-translocation complex SecYEG. Nature. 2002 Aug 08; 418(6898):662-5. PMID: 12167867.
    Citations: 74     Fields:    Translation:Cells
  110. Rapoport T. Profile: Tom Rapoport interviewed by Rabiya S. Tuma. Trends Cell Biol. 2002 Jun; 12(6):288-9. PMID: 12074889.
    Citations:    Fields:    
  111. Heinrich R, Neel BG, Rapoport TA. Mathematical models of protein kinase signal transduction. Mol Cell. 2002 May; 9(5):957-70. PMID: 12049733.
    Citations: 134     Fields:    Translation:Cells
  112. Rolls MM, Hall DH, Victor M, Stelzer EH, Rapoport TA. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell. 2002 May; 13(5):1778-91. PMID: 12006669.
    Citations: 67     Fields:    Translation:AnimalsCells
  113. Tsai B, Ye Y, Rapoport TA. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol. 2002 Apr; 3(4):246-55. PMID: 11994744.
    Citations: 179     Fields:    Translation:HumansAnimalsCells
  114. Ye Y, Meyer HH, Rapoport TA. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature. 2001 Dec 06; 414(6864):652-6. PMID: 11740563.
    Citations: 387     Fields:    Translation:AnimalsCells
  115. Horwich AL, Fenton WA, Rapoport TA. Protein folding taking shape. Workshop on molecular chaperones. EMBO Rep. 2001 Dec; 2(12):1068-73. PMID: 11743017.
    Citations: 6     Fields:    Translation:Cells
  116. Verhey KJ, Rapoport TA. Kinesin carries the signal. Trends Biochem Sci. 2001 Sep; 26(9):545-50. PMID: 11551791.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  117. Shamu CE, Flierman D, Ploegh HL, Rapoport TA, Chau V. Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol Biol Cell. 2001 Aug; 12(8):2546-55. PMID: 11514634.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  118. Collinson I, Breyton C, Duong F, Tziatzios C, Schubert D, Or E, Rapoport T, Kühlbrandt W. Projection structure and oligomeric properties of a bacterial core protein translocase. EMBO J. 2001 May 15; 20(10):2462-71. PMID: 11350935.
    Citations: 39     Fields:    Translation:Cells
  119. Tsai B, Rodighiero C, Lencer WI, Rapoport TA. Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell. 2001 Mar 23; 104(6):937-48. PMID: 11290330.
    Citations: 153     Fields:    Translation:AnimalsCells
  120. Verhey KJ, Meyer D, Deehan R, Blenis J, Schnapp BJ, Rapoport TA, Margolis B. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J Cell Biol. 2001 Mar 05; 152(5):959-70. PMID: 11238452.
    Citations: 171     Fields:    Translation:AnimalsCells
  121. Liebermeister W, Rapoport TA, Heinrich R. Ratcheting in post-translational protein translocation: a mathematical model. J Mol Biol. 2001 Jan 19; 305(3):643-56. PMID: 11152619.
    Citations: 14     Fields:    Translation:Cells
  122. Menetret JF, Neuhof A, Morgan DG, Plath K, Radermacher M, Rapoport TA, Akey CW. The structure of ribosome-channel complexes engaged in protein translocation. Mol Cell. 2000 Nov; 6(5):1219-32. PMID: 11106759.
    Citations: 57     Fields:    Translation:AnimalsCells
  123. Plath K, Rapoport TA. Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum. J Cell Biol. 2000 Oct 02; 151(1):167-78. PMID: 11018062.
    Citations: 23     Fields:    Translation:AnimalsCells
  124. Morgan DG, Ménétret JF, Radermacher M, Neuhof A, Akey IV, Rapoport TA, Akey CW. A comparison of the yeast and rabbit 80 S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments. J Mol Biol. 2000 Aug 11; 301(2):301-21. PMID: 10926511.
    Citations: 16     Fields:    Translation:AnimalsCells
  125. Prinz WA, Grzyb L, Veenhuis M, Kahana JA, Silver PA, Rapoport TA. Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Biol. 2000 Aug 07; 150(3):461-74. PMID: 10931860.
    Citations: 125     Fields:    Translation:AnimalsCells
  126. Heinrich SU, Mothes W, Brunner J, Rapoport TA. The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell. 2000 Jul 21; 102(2):233-44. PMID: 10943843.
    Citations: 82     Fields:    Translation:AnimalsCells
  127. Prinz A, Behrens C, Rapoport TA, Hartmann E, Kalies KU. Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA. EMBO J. 2000 Apr 17; 19(8):1900-6. PMID: 10775273.
    Citations: 35     Fields:    Translation:AnimalsCells
  128. Dreier L, Rapoport TA. In vitro formation of the endoplasmic reticulum occurs independently of microtubules by a controlled fusion reaction. J Cell Biol. 2000 Mar 06; 148(5):883-98. PMID: 10704440.
    Citations: 68     Fields:    Translation:AnimalsCells
  129. Hinkle B, Rolls MM, Stein P, Rapoport T, Terasaki M. Ran is associated with chromosomes during starfish oocyte meiosis and embryonic mitoses. Zygote. 2000; 8 Suppl 1:S91. PMID: 11191341.
    Citations:    Fields:    Translation:AnimalsCells
  130. Shamu CE, Story CM, Rapoport TA, Ploegh HL. The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol. 1999 Oct 04; 147(1):45-58. PMID: 10508854.
    Citations: 42     Fields:    Translation:HumansCells
  131. Rapoport TA, Matlack KE, Plath K, Misselwitz B, Staeck O. Posttranslational protein translocation across the membrane of the endoplasmic reticulum. Biol Chem. 1999 Oct; 380(10):1143-50. PMID: 10595576.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  132. Schröder K, Martoglio B, Hofmann M, Hölscher C, Hartmann E, Prehn S, Rapoport TA, Dobberstein B. Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J. 1999 Sep 01; 18(17):4804-15. PMID: 10469658.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  133. Misselwitz B, Staeck O, Matlack KE, Rapoport TA. Interaction of BiP with the J-domain of the Sec63p component of the endoplasmic reticulum protein translocation complex. J Biol Chem. 1999 Jul 16; 274(29):20110-5. PMID: 10400622.
    Citations: 28     Fields:    Translation:Cells
  134. Rolls MM, Stein PA, Taylor SS, Ha E, McKeon F, Rapoport TA. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol. 1999 Jul 12; 146(1):29-44. PMID: 10402458.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  135. Matlack KE, Misselwitz B, Plath K, Rapoport TA. BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane. Cell. 1999 May 28; 97(5):553-64. PMID: 10367885.
    Citations: 95     Fields:    Translation:AnimalsCells
  136. Meyer TH, Ménétret JF, Breitling R, Miller KR, Akey CW, Rapoport TA. The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex. J Mol Biol. 1999 Jan 29; 285(4):1789-800. PMID: 9917412.
    Citations: 39     Fields:    Translation:Cells
  137. Verhey KJ, Lizotte DL, Abramson T, Barenboim L, Schnapp BJ, Rapoport TA. Light chain-dependent regulation of Kinesin's interaction with microtubules. J Cell Biol. 1998 Nov 16; 143(4):1053-66. PMID: 9817761.
    Citations: 88     Fields:    Translation:AnimalsCells
  138. Misselwitz B, Staeck O, Rapoport TA. J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences. Mol Cell. 1998 Nov; 2(5):593-603. PMID: 9844632.
    Citations: 80     Fields:    Translation:Cells
  139. Plath K, Mothes W, Wilkinson BM, Stirling CJ, Rapoport TA. Signal sequence recognition in posttranslational protein transport across the yeast ER membrane. Cell. 1998 Sep 18; 94(6):795-807. PMID: 9753326.
    Citations: 104