Harvard Catalyst Profiles

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Ramesh Shivdasani, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK121540 (SHIVDASANI, RAMESH A) Jun 1, 2019 - Mar 31, 2023
    Cellular and molecular characterization of the digestive tract sub-epithelium
    Role: Principal Investigator
  2. U01DK103152 (SHIVDASANI, RAMESH A) Sep 1, 2014 - Aug 31, 2024
    Anatomic and functional characterization of the intestinal crypt-villus niche
    Role: Principal Investigator
  3. R01DK082889 (SHIVDASANI, RAMESH A) Sep 1, 2010 - Aug 31, 2017
    Regulation of intestinal genes by CDX2 and other tissue-restricted transcription factors
    Role: Principal Investigator
  4. RC2CA148222 (SHIVDASANI, RAMESH A) Sep 30, 2009 - Aug 31, 2011
    Comprehensive Phenotypic Comparison of Normal and Cancer Stem Cells
    Role: Co-Principal Investigator
  5. R01DK081113 (SHIVDASANI, RAMESH A) Apr 1, 2008 - Aug 31, 2018
    Transcriptional control of gut epithelial homeostasis and regeneration
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021 Mar 12; 4(1):332. PMID: 33712729.
  2. Tsai PY, Lee MS, Jadhav U, Naqvi I, Madha S, Adler A, Mistry M, Naumenko S, Lewis CA, Hitchcock DS, Roberts FR, DelNero P, Hank T, Honselmann KC, Morales Oyarvide V, Mino-Kenudson M, Clish CB, Shivdasani RA, Kalaany NY. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021 Mar 09; 118(10). PMID: 33653947.
    Citations: 1     Fields:    
  3. Shivdasani RA, Clevers H, de Sauvage FJ. Tissue regeneration: Reserve or reverse? Science. 2021 Feb 19; 371(6531):784-786. PMID: 33602845.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Giraud J, Foroutan M, Boubaker-Vitre J, Grillet F, Homayed Z, Jadhav U, Crespy P, Breuker C, Bourgaux JF, Hazerbroucq J, Pignodel C, Brulin B, Shivdasani RA, Jay P, Hollande F, Pannequin J. Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis. Transl Oncol. 2021 Feb; 14(2):101001. PMID: 33360299.
  5. Saxena M, Shivdasani RA. Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells. Annu Rev Physiol. 2021 02 10; 83:405-427. PMID: 33234018.
    Citations:    Fields:    
  6. McCarthy N, Kraiczy J, Shivdasani RA. Cellular and molecular architecture of the intestinal stem cell niche. Nat Cell Biol. 2020 09; 22(9):1033-1041. PMID: 32884148.
    Citations: 4     Fields:    Translation:HumansAnimals
  7. Verzi MP, Shivdasani RA. Epigenetic regulation of intestinal stem cell differentiation. Am J Physiol Gastrointest Liver Physiol. 2020 08 01; 319(2):G189-G196. PMID: 32628072.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH. Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 03 09; 52(5):647-658.e6. PMID: 32155439.
    Citations: 5     Fields:    Translation:AnimalsCells
  9. McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RA. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5. PMID: 32084389.
    Citations: 17     Fields:    Translation:Cells
  10. Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A, Wucherpfennig K, Michor F, Clevers H, Shivdasani RA. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6. PMID: 32084390.
    Citations: 22     Fields:    Translation:Cells
  11. Jadhav U, Manieri E, Nalapareddy K, Madha S, Chakrabarti S, Wucherpfennig K, Barefoot M, Shivdasani RA. Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5. PMID: 32027840.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Kim CK, Saxena M, Maharjan K, Song JJ, Shroyer KR, Bialkowska AB, Shivdasani RA, Yang VW. Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells. Cell Mol Gastroenterol Hepatol. 2020; 9(4):587-609. PMID: 31778829.
    Citations: 6     Fields:    
  13. Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, Conemans EB, Morsink FHM, Graham MK, Valk GD, Vriens MR, Castillo CF, Ferrone CR, Adar T, Bowden M, Whitton HJ, Da Silva A, Font-Tello A, Long HW, Gaskell E, Shoresh N, Heaphy CM, Sicinska E, Kulke MH, Chung DC, Bernstein BE, Shivdasani RA. Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 Oct; 25(10):1627. PMID: 31501535.
    Citations:    Fields:    
  14. Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, Conemans EB, Morsink FHM, Graham MK, Valk GD, Vriens MR, Castillo CF, Ferrone CR, Adar T, Bowden M, Whitton HJ, Da Silva A, Font-Tello A, Long HW, Gaskell E, Shoresh N, Heaphy CM, Sicinska E, Kulke MH, Chung DC, Bernstein BE, Shivdasani RA. Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 08; 25(8):1260-1265. PMID: 31263286.
    Citations: 26     Fields:    Translation:HumansCells
  15. Jadhav U, Cavazza A, Banerjee KK, Xie H, O'Neill NK, Saenz-Vash V, Herbert Z, Madha S, Orkin SH, Zhai H, Shivdasani RA. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019 05 02; 74(3):542-554.e5. PMID: 30905509.
    Citations: 20     Fields:    Translation:AnimalsCells
  16. Kumar N, Tsai YH, Chen L, Zhou A, Banerjee KK, Saxena M, Huang S, Toke NH, Xing J, Shivdasani RA, Spence JR, Verzi MP. The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development. 2019 03 01; 146(5). PMID: 30745430.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  17. Jadhav U, Shivdasani RA. Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell. 2019 02 21; 176(5):949-951. PMID: 30794779.
    Citations:    Fields:    Translation:AnimalsCells
  18. Witwicki RM, Ekram MB, Qiu X, Janiszewska M, Shu S, Kwon M, Trinh A, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, Schlabach M, deWeck A, Keen N, Chan HM, Ruddy D, Rejtar T, Sovath S, Silver S, Sellers WR, Jagani Z, Hogarty MD, Roberts C, Brown M, Stegmaier K, Long H, Shivdasani RA, Pellman D, Polyak K. TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Rep. 2018 10 30; 25(5):1255-1267.e5. PMID: 30380416.
    Citations: 8     Fields:    Translation:HumansCells
  19. Banerjee KK, Saxena M, Kumar N, Chen L, Cavazza A, Toke NH, O'Neill NK, Madha S, Jadhav U, Verzi MP, Shivdasani RA. Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev. 2018 11 01; 32(21-22):1430-1442. PMID: 30366903.
    Citations: 8     Fields:    Translation:AnimalsCells
  20. Shivdasani RA. Limited gut cell repertoire for multiple hormones. Nat Cell Biol. 2018 08; 20(8):865-867. PMID: 30038256.
    Citations: 2     Fields:    Translation:Cells
  21. Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS. RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). PMID: 29500225.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  22. Saxena M, Roman AKS, O'Neill NK, Sulahian R, Jadhav U, Shivdasani RA. Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017 12 01; 31(23-24):2391-2404. PMID: 29321178.
    Citations: 9     Fields:    Translation:AnimalsCells
  23. Jadhav U, Saxena M, O'Neill NK, Saadatpour A, Yuan GC, Herbert Z, Murata K, Shivdasani RA. Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):65-77.e5. PMID: 28648363.
    Citations: 66     Fields:    Translation:AnimalsCells
  24. Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA. A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jul; 153(1):e6-e13. PMID: 28583825.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84. PMID: 28482897.
    Citations: 60     Fields:    Translation:HumansAnimals
  26. Schumacher SE, Shim BY, Corso G, Ryu MH, Kang YK, Roviello F, Saksena G, Peng S, Shivdasani RA, Bass AJ, Beroukhim R. Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients. PLoS One. 2017; 12(4):e0176045. PMID: 28426752.
    Citations: 11     Fields:    Translation:Humans
  27. Mathur R, Alver BH, San Roman AK, Wilson BG, Wang X, Agoston AT, Park PJ, Shivdasani RA, Roberts CW. ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet. 2017 Feb; 49(2):296-302. PMID: 27941798.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  28. Cejas P, Cavazza A, Yandava CN, Moreno V, Horst D, Moreno-Rubio J, Burgos E, Mendiola M, Taing L, Goel A, Feliu J, Shivdasani RA. Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. Cancer Res. 2017 02 01; 77(3):766-779. PMID: 27899379.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  29. Jadhav U, Shivdasani RA. Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2(6):714-715. PMID: 28174745.
    Citations:    Fields:    
  30. Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060. PMID: 27524622.
    Citations: 24     Fields:    Translation:AnimalsCells
  31. Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K. Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep. 2016 08 16; 16(7):1929-41. PMID: 27498859.
    Citations: 22     Fields:    Translation:AnimalsCells
  32. Zang C, Luyten A, Chen J, Liu XS, Shivdasani RA. NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes. Sci Rep. 2016 07 26; 6:30255. PMID: 27457419.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  33. Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA. Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400. PMID: 27212235.
    Citations: 36     Fields:    Translation:AnimalsCells
  34. Cejas P, Li L, O'Neill NK, Duarte M, Rao P, Bowden M, Zhou CW, Mendiola M, Burgos E, Feliu J, Moreno-Rubio J, Guadalajara H, Moreno V, García-Olmo D, Bellmunt J, Mullane S, Hirsch M, Sweeney CJ, Richardson A, Liu XS, Brown M, Shivdasani RA, Long HW. Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles. Nat Med. 2016 06; 22(6):685-91. PMID: 27111282.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  35. Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. PMID: 26908146.
    Citations: 37     Fields:    Translation:AnimalsCells
  36. Kim TH, Shivdasani RA. Stomach development, stem cells and disease. Development. 2016 Feb 15; 143(4):554-65. PMID: 26884394.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  37. Bertaux-Skeirik N, Centeno J, Feng R, Schumacher MA, Shivdasani RA, Zavros Y. Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods Mol Biol. 2016; 1422:23-31. PMID: 27246019.
    Citations: 5     Fields:    Translation:AnimalsCells
  38. Hanyuda A, Kim SA, Martinez-Fernandez A, Qian ZR, Yamauchi M, Nishihara R, Morikawa T, Liao X, Inamura K, Mima K, Cao Y, Zhang X, Wu K, Chan AT, Giovannucci EL, Meyerhardt JA, Fuchs CS, Shivdasani RA, Ogino S. Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer. Ann Surg Oncol. 2016 Mar; 23(3):908-17. PMID: 26577117.
    Citations: 16     Fields:    Translation:HumansCells
  39. Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA. SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):598-609.e6. PMID: 26516633.
    Citations: 2     Fields:    
  40. San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. PMID: 26489894.
    Citations: 18     Fields:    Translation:AnimalsCells
  41. Pomerantz MM, Li F, Takeda DY, Lenci R, Chonkar A, Chabot M, Cejas P, Vazquez F, Cook J, Shivdasani RA, Bowden M, Lis R, Hahn WC, Kantoff PW, Brown M, Loda M, Long HW, Freedman ML. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nat Genet. 2015 Nov; 47(11):1346-51. PMID: 26457646.
    Citations: 119     Fields:    Translation:HumansCells
  42. Jayewickreme CD, Shivdasani RA. Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 01; 405(1):21-32. PMID: 26057579.
    Citations: 12     Fields:    Translation:Animals
  43. Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y. The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol. 2015 Apr 15; 593(8):1809-27. PMID: 25605613.
    Citations: 36     Fields:    Translation:AnimalsCells
  44. Verzi MP, Shin H, San Roman AK, Liu XS, Shivdasani RA. Erratum for Verzi et al., Intestinal Master Transcription Factor CDX2 Controls Chromatin Access for Partner Transcription Factor Binding. Mol Cell Biol. 2015 Jan 15; 35(2):496. PMID: 25535405.
  45. San Roman AK, Aronson BE, Krasinski SD, Shivdasani RA, Verzi MP. Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2. J Biol Chem. 2015 Jan 16; 290(3):1850-60. PMID: 25488664.
    Citations: 20     Fields:    Translation:AnimalsCells
  46. Luyten A, Zang C, Liu XS, Shivdasani RA. Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev. 2014 Aug 15; 28(16):1827-39. PMID: 25128499.
    Citations: 18     Fields:    Translation:AnimalsCells
  47. Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell. 2014 Aug 14; 158(4):889-902. PMID: 25126792.
    Citations: 104     Fields:    Translation:AnimalsCells
  48. Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y. Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 2014 Sep; 147(3):655-666.e9. PMID: 24859162.
    Citations: 17     Fields:    Translation:AnimalsCells
  49. Shivdasani RA. Radiation redux: reserve intestinal stem cells miss the call to duty. Cell Stem Cell. 2014 Feb 06; 14(2):135-6. PMID: 24506878.
    Citations: 2     Fields:    Translation:AnimalsCells
  50. San Roman AK, Jayewickreme CD, Murtaugh LC, Shivdasani RA. Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports. 2014 Feb 11; 2(2):127-34. PMID: 24527386.
    Citations: 42     Fields:    Translation:AnimalsCells
  51. Kim TH, Li F, Ferreiro-Neira I, Ho LL, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA. Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 2014 Feb 27; 506(7489):511-5. PMID: 24413398.
    Citations: 84     Fields:    Translation:AnimalsCells
  52. Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA. An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 2014 Dec 04; 33(49):5637-48. PMID: 24317510.
    Citations: 23     Fields:    Translation:HumansCells
  53. Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, Banck MS, Kanwar R, Kulkarni AA, Karpathakis A, Manzo V, Contractor T, Philips J, Nickerson E, Pho N, Hooshmand SM, Brais LK, Lawrence MS, Pugh T, McKenna A, Sivachenko A, Cibulskis K, Carter SL, Ojesina AI, Freeman S, Jones RT, Voet D, Saksena G, Auclair D, Onofrio R, Shefler E, Sougnez C, Grimsby J, Green L, Lennon N, Meyer T, Caplin M, Chung DC, Beutler AS, Ogino S, Thirlwell C, Shivdasani R, Asa SL, Harris CR, Getz G, Kulke M, Meyerson M. Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6. PMID: 24185511.
    Citations: 97     Fields:    Translation:Humans
  54. Pignon JC, Grisanzio C, Geng Y, Song J, Shivdasani RA, Signoretti S. p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8105-10. PMID: 23620512.
    Citations: 93     Fields:    Translation:AnimalsCells
  55. Ho LL, Sinha A, Verzi M, Bernt KM, Armstrong SA, Shivdasani RA. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol. 2013 May; 33(9):1735-45. PMID: 23428873.
    Citations: 9     Fields:    Translation:AnimalsCells
  56. Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J. Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. J Biol Chem. 2013 Mar 29; 288(13):9017-27. PMID: 23393141.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  57. Verzi MP, Shin H, San Roman AK, Liu XS, Shivdasani RA. Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding. Mol Cell Biol. 2013 Jan; 33(2):281-92. PMID: 23129810.
    Citations: 28     Fields:    Translation:AnimalsCells
  58. Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR. Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med. 2012 Aug 22; 4(148):148ra117. PMID: 22914623.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  59. Kim TH, Shivdasani RA. Stem cell niches: famished Paneth cells, gluttonous stem cells. Curr Biol. 2012 Jul 24; 22(14):R579-80. PMID: 22835795.
    Citations:    Fields:    Translation:AnimalsCells
  60. Dulak AM, Schumacher SE, van Lieshout J, Imamura Y, Fox C, Shim B, Ramos AH, Saksena G, Baca SC, Baselga J, Tabernero J, Barretina J, Enzinger PC, Corso G, Roviello F, Lin L, Bandla S, Luketich JD, Pennathur A, Meyerson M, Ogino S, Shivdasani RA, Beer DG, Godfrey TE, Beroukhim R, Bass AJ. Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res. 2012 Sep 01; 72(17):4383-93. PMID: 22751462.
    Citations: 114     Fields:    Translation:HumansCells
  61. Shivdasani RA. GEFs on the RhoAd to a colossal nucleus. Dev Cell. 2012 Mar 13; 22(3):471-2. PMID: 22421037.
    Citations:    Fields:    
  62. Kim TH, Escudero S, Shivdasani RA. Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3932-7. PMID: 22355124.
    Citations: 96     Fields:    Translation:AnimalsCells
  63. Horst D, Chen J, Morikawa T, Ogino S, Kirchner T, Shivdasani RA. Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling. Cancer Res. 2012 Mar 15; 72(6):1547-56. PMID: 22318865.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  64. Ho Sui SJ, Begley K, Reilly D, Chapman B, McGovern R, Rocca-Sera P, Maguire E, Altschuler GM, Hansen TA, Sompallae R, Krivtsov A, Shivdasani RA, Armstrong SA, Culhane AC, Correll M, Sansone SA, Hofmann O, Hide W. The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. Nucleic Acids Res. 2012 Jan; 40(Database issue):D984-91. PMID: 22121217.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  65. Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, Baselga J, Liu C, Shivdasani RA, Ogino S, Birren BW, Huttenhower C, Garrett WS, Meyerson M. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22(2):292-8. PMID: 22009990.
    Citations: 602     Fields:    Translation:HumansCells
  66. Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, Ercan D, Rogers A, Roncalli M, Takeda M, Fujisaka Y, Philips J, Shimizu T, Maenishi O, Cho Y, Sun J, Destro A, Taira K, Takeda K, Okabe T, Swanson J, Itoh H, Takada M, Lifshits E, Okuno K, Engelman JA, Shivdasani RA, Nishio K, Fukuoka M, Varella-Garcia M, Nakagawa K, Jänne PA. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011 Sep 07; 3(99):99ra86. PMID: 21900593.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  67. Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA. Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug; 138(15):3225-33. PMID: 21750033.
    Citations: 10     Fields:    Translation:AnimalsCells
  68. San Roman AK, Shivdasani RA. Boundaries, junctions and transitions in the gastrointestinal tract. Exp Cell Res. 2011 Nov 15; 317(19):2711-8. PMID: 21802415.
    Citations: 20     Fields:    Translation:HumansAnimals
  69. Woo J, Miletich I, Kim BM, Sharpe PT, Shivdasani RA. Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. PLoS One. 2011; 6(7):e22493. PMID: 21799872.
    Citations: 22     Fields:    Translation:AnimalsCells
  70. Zhang J, Roberts TM, Shivdasani RA. Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology. 2011 Jul; 141(1):50-61. PMID: 21723986.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  71. Verzi MP, Shin H, Ho LL, Liu XS, Shivdasani RA. Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol. 2011 May; 31(10):2026-39. PMID: 21402776.
    Citations: 51     Fields:    Translation:AnimalsCells
  72. Kim TH, Shivdasani RA. Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 2011 Apr 11; 208(4):677-88. PMID: 21402740.
    Citations: 52     Fields:    Translation:AnimalsCells
  73. Kim BM, Woo J, Kanellopoulou C, Shivdasani RA. Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development. 2011 Mar; 138(6):1081-6. PMID: 21307095.
    Citations: 8     Fields:    Translation:AnimalsCells
  74. Kim TH, Shivdasani RA. Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem. 2011 Apr 01; 286(13):11427-33. PMID: 21282114.
    Citations: 42     Fields:    Translation:AnimalsCells
  75. Mills JC, Shivdasani RA. Gastric epithelial stem cells. Gastroenterology. 2011 Feb; 140(2):412-24. PMID: 21144849.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  76. Verzi MP, Shin H, He HH, Sulahian R, Meyer CA, Montgomery RK, Fleet JC, Brown M, Liu XS, Shivdasani RA. Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell. 2010 Nov 16; 19(5):713-26. PMID: 21074721.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  77. Verzi MP, Shivdasani RA. Stem cells: The intestinal-crypt casino. Nature. 2010 Oct 28; 467(7319):1055-6. PMID: 20981089.
    Citations: 4     Fields:    Translation:AnimalsCells
  78. Horst D, Gu X, Bhasin M, Yang Q, Verzi M, Lin D, Joseph M, Zhang X, Chen W, Li YP, Shivdasani RA, Libermann TA. Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 05; 285(45):35047-55. PMID: 20801882.
    Citations: 17     Fields:    Translation:Animals
  79. Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15157-62. PMID: 20696899.
    Citations: 40     Fields:    Translation:HumansCells
  80. Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9. PMID: 20430747.
    Citations: 69     Fields:    Translation:AnimalsCells
  81. Echtler K, Stark K, Lorenz M, Kerstan S, Walch A, Jennen L, Rudelius M, Seidl S, Kremmer E, Emambokus NR, von Bruehl ML, Frampton J, Isermann B, Genzel-Boroviczény O, Schreiber C, Mehilli J, Kastrati A, Schwaiger M, Shivdasani RA, Massberg S. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med. 2010 Jan; 16(1):75-82. PMID: 19966813.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  82. MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18; 4(11):e7887. PMID: 19924296.
    Citations: 170     Fields:    Translation:Humans
  83. Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Ribeiro U, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Nov; 41(11):1238-42. PMID: 19801978.
    Citations: 425     Fields:    Translation:Humans
  84. Kunert S, Meyer I, Fleischhauer S, Wannack M, Fiedler J, Shivdasani RA, Schulze H. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood. 2009 Dec 24; 114(27):5532-40. PMID: 19801445.
    Citations: 12     Fields:    Translation:AnimalsCells
  85. Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, Silver J, Ogino S, Hooshmand S, Kwak E, Freed E, Meyerhardt JA, Saridaki Z, Georgoulias V, Finkelstein D, Fuchs CS, Kulke MH, Shivdasani RA. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer. 2009 Aug 04; 101(3):465-72. PMID: 19603024.
    Citations: 123     Fields:    Translation:Humans
  86. Baba Y, Nosho K, Shima K, Freed E, Irahara N, Philips J, Meyerhardt JA, Hornick JL, Shivdasani RA, Fuchs CS, Ogino S. Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Clin Cancer Res. 2009 Jul 15; 15(14):4665-73. PMID: 19584150.
    Citations: 58     Fields:    Translation:HumansCells
  87. Chen Z, Shivdasani RA. Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders. J Thromb Haemost. 2009 Jul; 7 Suppl 1:272-6. PMID: 19630815.
    Citations: 8     Fields:    Translation:Humans
  88. Pomerantz MM, Ahmadiyeh N, Jia L, Herman P, Verzi MP, Doddapaneni H, Beckwith CA, Chan JA, Hills A, Davis M, Yao K, Kehoe SM, Lenz HJ, Haiman CA, Yan C, Henderson BE, Frenkel B, Barretina J, Bass A, Tabernero J, Baselga J, Regan MM, Manak JR, Shivdasani R, Coetzee GA, Freedman ML. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009 Aug; 41(8):882-4. PMID: 19561607.
    Citations: 336     Fields:    Translation:HumansCells
  89. Montgomery RK, Shivdasani RA. Prominin1 (CD133) as an intestinal stem cell marker: promise and nuance. Gastroenterology. 2009 Jun; 136(7):2051-4. PMID: 19409288.
    Citations: 4     Fields:    Translation:AnimalsCells
  90. Wuelling M, Kaiser FJ, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A. Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009 Apr 01; 328(1):40-53. PMID: 19389374.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  91. Verzi MP, Stanfel MN, Moses KA, Kim BM, Zhang Y, Schwartz RJ, Shivdasani RA, Zimmer WE. Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology. 2009 May; 136(5):1701-10. PMID: 19208343.
    Citations: 29     Fields:    Translation:Animals
  92. Eeckhoute J, Lupien M, Meyer CA, Verzi MP, Shivdasani RA, Liu XS, Brown M. Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res. 2009 Mar; 19(3):372-80. PMID: 19129543.
    Citations: 61     Fields:    Translation:HumansCells
  93. Kantaputra P, Miletich I, Lüdecke HJ, Suzuki EY, Praphanphoj V, Shivdasani R, Wuelling M, Vortkamp A, Napierala D, Sharpe PT. Tricho-rhino-phalangeal syndrome with supernumerary teeth. J Dent Res. 2008 Nov; 87(11):1027-31. PMID: 18946009.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  94. Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S, Bojarski E, Mermel C, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE, Fuchs CS, Loda M, Shivdasani RA, Meyerson M, Hahn WC. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25; 455(7212):547-51. PMID: 18794900.
    Citations: 287     Fields:    Translation:HumansCells
  95. Kulke MH, Freed E, Chiang DY, Philips J, Zahrieh D, Glickman JN, Shivdasani RA. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chromosomes Cancer. 2008 Jul; 47(7):591-603. PMID: 18383209.
    Citations: 28     Fields:    Translation:HumansCells
  96. Hafler BP, Choi MY, Shivdasani RA, Rowitch DH. Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res. 2008 Jul 30; 1222:42-50. PMID: 18586225.
    Citations: 7     Fields:    Translation:AnimalsCells
  97. Verzi MP, Khan AH, Ito S, Shivdasani RA. Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008 Aug; 135(2):591-600. PMID: 18558092.
    Citations: 24     Fields:    Translation:AnimalsCells
  98. Napierala D, Sam K, Morello R, Zheng Q, Munivez E, Shivdasani RA, Lee B. Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008 Jul 15; 17(14):2244-54. PMID: 18424451.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  99. Verzi MP, Shivdasani RA. Wnt signaling in gut organogenesis. Organogenesis. 2008 Apr; 4(2):87-91. PMID: 19279719.
    Citations: 14     Fields:    
  100. Schulze H, Dose M, Korpal M, Meyer I, Italiano JE, Shivdasani RA. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem. 2008 May 16; 283(20):14109-19. PMID: 18347012.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  101. Choi MY, Romer AI, Wang Y, Wu MP, Ito S, Leiter AB, Shivdasani RA. Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May; 28(10):3208-18. PMID: 18347062.
    Citations: 16     Fields:    Translation:AnimalsCells
  102. Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16. PMID: 18230754.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  103. Kulke MH, Freed E, Chiang D, Philips J, Zahrieh D, Glickman JN, Shivdasani RA. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chrom Cancer. 2008; 47:591-603.
  104. Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet. 2008 Jan; 40(1):51-60. PMID: 17994017.
    Citations: 108     Fields:    Translation:AnimalsCells
  105. Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, Van de Ven WJ, Shivdasani RA. Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov; 6(5):406-13. PMID: 17983586.
    Citations: 19     Fields:    Translation:AnimalsCells
  106. Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Shivdasani RA, von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70. PMID: 17885137.
    Citations: 218     Fields:    Translation:AnimalsCells
  107. Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13. PMID: 17855428.
    Citations: 28     Fields:    Translation:AnimalsCells
  108. Kim BM, Mao J, Taketo MM, Shivdasani RA. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38. PMID: 17681174.
    Citations: 44     Fields:    Translation:AnimalsCells
  109. Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA. The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 2007 Jul 01; 110(1):171-9. PMID: 17392504.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  110. Chen Z, Hu M, Shivdasani RA. Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. Blood. 2007 Feb 15; 109(4):1451-9. PMID: 17047147.
    Citations: 29     Fields:    Translation:AnimalsCells
  111. Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA. A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct; 133(20):4119-29. PMID: 16971476.
    Citations: 45     Fields:    Translation:AnimalsCells
  112. Shivdasani RA. MicroRNAs: regulators of gene expression and cell differentiation. Blood. 2006 Dec 01; 108(12):3646-53. PMID: 16882713.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  113. Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood. 2006 May 15; 107(10):3868-75. PMID: 16434494.
    Citations: 58     Fields:    Translation:AnimalsCells
  114. Hu M, Shivdasani RA. Overlapping gene expression in fetal mouse intestine development and human colorectal cancer. Cancer Res. 2005 Oct 01; 65(19):8715-22. PMID: 16204040.
    Citations: 17     Fields:    Translation:HumansAnimals
  115. Patel SR, Richardson JL, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85. PMID: 16118321.
    Citations: 67     Fields:    Translation:AnimalsCells
  116. Richardson JL, Shivdasani RA, Boers C, Hartwig JH, Italiano JE. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75. PMID: 16118320.
    Citations: 42     Fields:    Translation:AnimalsCells
  117. Schulze H, Shivdasani RA. Mechanisms of thrombopoiesis. J Thromb Haemost. 2005 Aug; 3(8):1717-24. PMID: 16102038.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  118. Shivdasani RA, Schulze H. Culture, expansion, and differentiation of murine megakaryocytes. Curr Protoc Immunol. 2005 Jul; Chapter 22:Unit 22F.6. PMID: 18432953.
    Citations: 17     Fields:    Translation:AnimalsCells
  119. Kim BM, Buchner G, Miletich I, Sharpe PT, Shivdasani RA. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell. 2005 Apr; 8(4):611-22. PMID: 15809042.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  120. Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Kia X, Shivdasani RA, Spiegelman BM. Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 01; 19(3):362-75. PMID: 15687259.
    Citations: 48     Fields:    Translation:AnimalsCells
  121. Shivdasani RA. A Fli in the ointment. Blood. 2005; 105:9-10.
  122. Schulze, Shivdasani RA. Culture and in vitro differentiation of murine megakaryocytes. In: Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. 2005; Chapter 22F:6.1-6.13.
  123. Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 2005 Jan; 132(2):415-27. PMID: 15604097.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  124. Schulze H, Korpal M, Bergmeier W, Italiano JE, Wahl SM, Shivdasani RA. Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 2004 Dec 15; 104(13):3949-57. PMID: 15315966.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  125. Schulze H, Shivdasani RA. Molecular mechanisms of megakaryocyte differentiation. Semin Thromb Hemost. 2004 Aug; 30(4):389-98. PMID: 15354260.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  126. Shivdasani RA. Lonely in Paris: when one gene copy isn't enough. J Clin Invest. 2004 Jul; 114(1):17-9. PMID: 15232606.
    Citations: 1     Fields:    Translation:HumansCells
  127. Derjuga A, Gourley TS, Holm TM, Heng HH, Shivdasani RA, Ahmed R, Andrews NC, Blank V. Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol. 2004 Apr; 24(8):3286-94. PMID: 15060151.
    Citations: 30     Fields:    Translation:AnimalsCells
  128. Tou L, Liu Q, Shivdasani RA. Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004 Apr; 24(8):3132-9. PMID: 15060137.
    Citations: 34     Fields:    Translation:AnimalsCells
  129. Lepourcelet M, Chen YN, France DS, Wang H, Crews P, Petersen F, Bruseo C, Wood AW, Shivdasani RA. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell. 2004 Jan; 5(1):91-102. PMID: 14749129.
    Citations: 220     Fields:    Translation:AnimalsCells
  130. Schulze H, Shivdasani RA. Molecular mechanisms of megakaryocyte differentiation and platelet production. Sem Thromb Hemost. 2004; 30:389-98.
  131. Kacena MA, Shivdasani RA, Wilson K, Xi Y, Troiano N, Nazarian A, Gundberg CM, Bouxsein ML, Lorenzo JA, Horowitz MC. Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res. 2004 Apr; 19(4):652-60. PMID: 15005853.
    Citations: 52     Fields:    Translation:AnimalsCells
  132. Tiwari S, Italiano JE, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC, Shivdasani RA. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 2003 Dec 01; 102(12):3970-9. PMID: 12907454.
    Citations: 29     Fields:    Translation:AnimalsCells
  133. Italiano JE, Shivdasani RA. Megakaryocytes and beyond: the birth of platelets. J Thromb Haemost. 2003 Jun; 1(6):1174-82. PMID: 12871316.
    Citations: 47     Fields:    Translation:HumansCells
  134. Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96. PMID: 12586623.
    Citations: 37     Fields:    Translation:AnimalsCells
  135. Leibowitz SB, Shivdasani RA, Kantoff PW. Management of extragonadal germ cell tumors. In: Raghavan D, editor. American Cancer Society Atlas of Clinical Oncology - Germ Cell Tumors. 2003; 243-64.
  136. Malik TH, Von Stechow D, Bronson RT, Shivdasani RA. Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec; 22(24):8592-600. PMID: 12446778.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  137. Lepourcelet M, Shivdasani RA. Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. J Biol Chem. 2002 Dec 06; 277(49):47732-40. PMID: 12359720.
    Citations: 9     Fields:    Translation:AnimalsCells
  138. Shivdasani RA. Molecular regulation of vertebrate early endoderm development. Dev Biol. 2002 Sep 15; 249(2):191-203. PMID: 12221001.
    Citations: 23     Fields:    Translation:Animals
  139. Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS. A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J. 2002 Sep-Oct; 8(5):395-9. PMID: 12416897.
    Citations: 61     Fields:    Translation:HumansCTClinical Trials
  140. Shivdasani R. An animal model for myelofibrosis. Blood. 2002 Aug 15; 100(4):1109. PMID: 12149182.
    Citations:    Fields:    Translation:Animals
  141. Ryan DP, Kulke MH, Fuchs CS, Grossbard ML, Grossman SR, Morgan JA, Earle CC, Shivdasani R, Kim H, Mayer RJ, Clark JW. A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma. Cancer. 2002 Jan 01; 94(1):97-103. PMID: 11815964.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  142. Poy F, Lepourcelet M, Shivdasani RA, Eck MJ. Structure of a human Tcf4-beta-catenin complex. Nat Struct Biol. 2001 Dec; 8(12):1053-7. PMID: 11713476.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  143. Schwer HD, Lecine P, Tiwari S, Italiano JE, Hartwig JH, Shivdasani RA. A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86. PMID: 11369202.
    Citations: 63     Fields:    Translation:AnimalsCells
  144. Malik TH, Shoichet SA, Latham P, Kroll TG, Peters LL, Shivdasani RA. Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J. 2001 Apr 02; 20(7):1715-25. PMID: 11285235.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  145. Livingston DM, Shivdasani R. Toward mechanism-based cancer care. JAMA. 2001 Feb 07; 285(5):588-93. PMID: 11176864.
    Citations: 4     Fields:    Translation:HumansAnimals
  146. Kim SW, Shivdasani RV. Regulation of megakaryocyte and erythroid differentiation by NF-E2. In: Licht J, Ravid K, editors. Trancription factors: Normal and malignant development of blood cells. 2001; 13-29.
  147. Shivdasani RA. Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells. 2001; 19(5):397-407. PMID: 11553848.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  148. Li YJ, Higgins RR, Pak BJ, Shivdasani RA, Ney PA, Archer M, Ben-David Y. p45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemias. Mol Cell Biol. 2001 Jan; 21(1):73-80. PMID: 11113182.
    Citations: 7     Fields:    Translation:AnimalsCells
  149. Zhang J, Rosenthal A, de Sauvage FJ, Shivdasani RA. Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev Biol. 2001 Jan 01; 229(1):188-202. PMID: 11133163.
    Citations: 15     Fields:    Translation:AnimalsCells
  150. Lecine P, Italiano JE, Kim SW, Villeval JL, Shivdasani RA. Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 2000 Aug 15; 96(4):1366-73. PMID: 10942379.
    Citations: 46     Fields:    Translation:AnimalsCells
  151. Malik TH, Shivdasani RA. Structure and expression of a novel frizzled gene isolated from the developing mouse gut. Biochem J. 2000 Aug 01; 349 Pt 3:829-34. PMID: 10903145.
    Citations: 2     Fields:    Translation:AnimalsCells
  152. Shoichet SA, Malik TH, Rothman JH, Shivdasani RA. Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4076-81. PMID: 10760276.
    Citations: 8     Fields:    Translation:AnimalsCells
  153. Italiano JE, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312. PMID: 10601342.
    Citations: 150     Fields:    Translation:AnimalsCells
  154. Levin J, Peng JP, Baker GR, Villeval JL, Lecine P, Burstein SA, Shivdasani RA. Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood. 1999 Nov 01; 94(9):3037-47. PMID: 10556187.
    Citations: 37     Fields:    Translation:Animals
  155. Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA. Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999 May 01; 93(9):2867-75. PMID: 10216081.
    Citations: 107     Fields:    Translation:AnimalsCells
  156. Lee YJ, Swencki B, Shoichet S, Shivdasani RA. A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem. 1999 Jan 15; 274(3):1566-72. PMID: 9880534.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  157. Lecine P, Villeval JL, Vyas P, Swencki B, Xu Y, Shivdasani RA. Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood. 1998 Sep 01; 92(5):1608-16. PMID: 9716588.
    Citations: 54     Fields:    Translation:AnimalsCells
  158. de Sauvage FJ, Villeval JL, Shivdasani RA. Regulation of megakaryocytopoiesis and platelet production: lessons from animal models. J Lab Clin Med. 1998 Jun; 131(6):496-501. PMID: 9626984.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  159. Martin F, van Deursen JM, Shivdasani RA, Jackson CW, Troutman AG, Ney PA. Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 01; 91(9):3459-66. PMID: 9558405.
    Citations: 16     Fields:    Translation:AnimalsCells
  160. Lecine P, Blank V, Shivdasani R. Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes. J Biol Chem. 1998 Mar 27; 273(13):7572-8. PMID: 9516460.
    Citations: 26     Fields:    Translation:AnimalsCells
  161. Lecine P, Shivdasani RA. Cellular and molecular biology of megakaryocyte differentiation in the absence of lineage-restricted transcription factors. Stem Cells. 1998; 16 Suppl 2:91-5. PMID: 11012181.
    Citations: 3     Fields:    Translation:AnimalsCells
  162. Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998; 16 Suppl 2:79-83. PMID: 11012179.
    Citations: 25     Fields:    Translation:AnimalsCells
  163. Shivdasani RA. Stem cell transcription factors. Hematol Oncol Clin North Am. 1997 Dec; 11(6):1199-206. PMID: 9443052.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  164. Deveaux S, Cohen-Kaminsky S, Shivdasani RA, Andrews NC, Filipe A, Kuzniak I, Orkin SH, Roméo PH, Mignotte V. p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J. 1997 Sep 15; 16(18):5654-61. PMID: 9312024.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  165. Shivdasani RA, Fielder P, Keller GA, Orkin SH, de Sauvage FJ. Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood. 1997 Sep 01; 90(5):1821-7. PMID: 9292514.
    Citations: 15     Fields:    Translation:HumansAnimals
  166. McDevitt MA, Fujiwara Y, Shivdasani RA, Orkin SH. An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7976-81. PMID: 9223298.
    Citations: 28     Fields:    Translation:AnimalsCells
  167. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 01; 16(13):3965-73. PMID: 9233806.
    Citations: 206     Fields:    Translation:AnimalsCells
  168. McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6781-5. PMID: 9192642.
    Citations: 85     Fields:    Translation:AnimalsCells
  169. Chan FY, Robinson J, Brownlie A, Shivdasani RA, Donovan A, Brugnara C, Kim J, Lau BC, Witkowska HE, Zon LI. Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700. PMID: 9002973.
    Citations: 19     Fields:    Translation:AnimalsCells
  170. Shivdasani RA. Transcription factors in megakaryocyte differentiation and gene expression. In: Hunt P, Kuter D, Sheridan W, Zucker-Franklin D, editors. Thrombopoiesis and thrombopoietins. 1997; 189-202.
  171. Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE. Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27. PMID: 8808627.
    Citations: 61     Fields:    Translation:AnimalsCells
  172. Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood. 1996 May 15; 87(10):4025-39. PMID: 8639758.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  173. Shivdasani RA, Kantoff PW. Extragonadal germ cell tumors. In: Raghavan D, Scher HI, Leibel SA, Lange P, editors. Principles and practice of genitourinary oncology. 1996; 751-64.
  174. Shivdasani RA. The role of transcription factor NF-E2 in megakaryocyte maturation and platelet production. Stem Cells. 1996; 14 Suppl 1:112-5. PMID: 11012210.
    Citations: 7     Fields:    Translation:AnimalsCells
  175. Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8690-4. PMID: 7567998.
    Citations: 60     Fields:    Translation:AnimalsCells
  176. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 1995 Jun 02; 81(5):695-704. PMID: 7774011.
    Citations: 195     Fields:    Translation:AnimalsCells
  177. Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 02; 373(6513):432-4. PMID: 7830794.
    Citations: 237     Fields:    Translation:AnimalsCells
  178. Shivdasani RA, Anderson KC. Transfusion-associated graft-versus-host disease. In: Petz LD, Swisher S, Kleinman S, Spence R, Strauss R, editors. Clinical practice of transfusion medicine. 1995; 931-46.
  179. Shivdasani RA, Anderson KC. HLA homozygosity and shared HLA haplotypes in the development of transfusion-associated graft-versus-host disease. Leuk Lymphoma. 1994 Oct; 15(3-4):227-34. PMID: 7866271.
    Citations: 1     Fields:    Translation:Humans
  180. Coffey MJ, Sanders GM, Eschenbacher WL, Tsien A, Shivdasani RA, Weber RW, Toews GB, McCune JW. The role of methotrexate in the management of steriod-dependent asthma. Chest. 1994; 105:117-21.
  181. Shivdasani RA, Anderson KC. Transfusion-associated graft-versus-host disease: scratching the surface. Transfusion. 1993 Sep; 33(9):696-7. PMID: 8212111.
    Citations:    Fields:    Translation:Humans
  182. Shivdasani RA, Hess JL, Skarin AT, Pinkus GS. Intermediate lymphocytic lymphoma: clinical and pathologic features of a recently characterized subtype of non-Hodgkin's lymphoma. J Clin Oncol. 1993 Apr; 11(4):802-111. PMID: 8478674.
    Citations: 3     Fields:    Translation:Humans
  183. Shivdasani RA, Haluska FG, Dock NL, Dover JS, Kineke EJ, Anderson KC. Brief report: graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors. N Engl J Med. 1993 Mar 18; 328(11):766-70. PMID: 8437597.