Harvard Catalyst Profiles

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Marcia Beurman Goldberg, M.D.

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Title
Institution
Department

Mentoring
Available: 09/01/14, Expires: 06/30/20

The student will investigate mechanisms by which proteins involved in virulence are secreted from bacterial pathogens, using genetic and molecular biological approaches.

Available: 09/01/14, Expires: 12/31/20

We are investigating the molecular mechanisms by which the intracellular pathogen Shigella causes disease. We are characterizing both the bacterial and the host factors required for pathogenesis, focusing on the mechanisms by which one modulates the other at the molecular level.

Available: 09/01/12, Expires: 12/31/20

Investigations into the mechanisms by which intracellular human pathogens of major importance worldwide are able to cause disease. Molecular and cellular biology.

Available: 12/01/18, Expires: 12/31/20

We investigate how intracellular bacterial pathogens cause disease. These bacteria secrete into the host cell cytosol an array of proteins that alter host cell function in ways that enhance infection. Students would investigate the mechanism of specific secreted bacterial proteins or host pathways in these processes.

Available: 12/01/18, Expires: 12/31/20

We are investigating the molecular mechanisms by which the intracellular pathogen Shigella causes disease. We are characterizing both the bacterial and the host factors required for pathogenesis, focusing on the mechanisms by which one modulates the other at the molecular level.

Pathogenesis Research[login at prompt]
Available: 09/01/19, Expires: 06/30/20

Investigations into the mechanisms by which bacterial pathogens cause disease and into the cell biology of bacterial proteins involved in virulence.

The student's project involves detailed investigations into the mechanisms by which the intracellular bacterial pathogen Shigella causes disease in humans. In particular, the project involves defining the molecular mechanisms by which bacterial proteins alter mammalian host cell signaling pathways to enhance bacterial infection.

Available: 07/24/17, Expires: 07/31/20

We investigate how intracellular bacterial pathogens cause disease. These bacteria secrete into the host cell cytosol an array of proteins that alter host cell function in ways that enhance infection. Students would investigate the mechanism of specific secreted bacterial proteins or host pathways in these processes.

Available: 07/01/17, Expires: 07/31/20

The rise of antibiotic resistance has been declared by the WHO to be the greatest threat to human health, with current deaths due to antibiotic resistant infection estimated to be currently 700,000 per year and projected to be 10 million per year by 2050. One major contributor to this problem is the inappropriate over-use of antibiotics, with recent CDC estimates suggesting that over 30% of prescriptions are unnecessary. Novel biomarkers that rapidly discriminate between states of infection from those that are non-infectious would be transforming in their ability to guide appropriate antibiotic use. We are working to develop such biomarkers.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32AI007061 (GOLDBERG, MARCIA B) Dec 1, 2016 - May 31, 2024
    NIH/NIAID
    Infectious Disease and Basic Microbiological Mechanisms
    Role: Principal Investigator
  2. R21AI101545 (GOLDBERG, MARCIA B) Sep 1, 2014 - Aug 31, 2016
    NIH/NIAID
    Bacterial cell envelope in polar positioning of autotransporter proteins
    Role: Principal Investigator
  3. R21AI113484 (GOLDBERG, MARCIA B) Jun 1, 2014 - May 31, 2016
    NIH/NIAID
    Shigella repression of innate immunity early during infection
    Role: Principal Investigator
  4. R21AI103676 (GOLDBERG, MARCIA B) Feb 1, 2013 - Jan 31, 2015
    NIH/NIAID
    The cellular filopodia mechanism in Shigella membrane protrusion formation
    Role: Principal Investigator
  5. R01AI081724 (GOLDBERG, MARCIA B) Jan 1, 2010 - Jun 30, 2022
    NIH/NIAID
    Host factors in Shigella flexneri infection
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N. An immune-cell signature of bacterial sepsis. Nat Med. 2020 03; 26(3):333-340. PMID: 32066974.
    Citations:    
  2. Russo BC, Duncan JK, Wiscovitch AL, Hachey AC, Goldberg MB. Activation of Shigella flexneri type 3 secretion requires a host-induced conformational change to the translocon pore. PLoS Pathog. 2019 11; 15(11):e1007928. PMID: 31725799.
    Citations:    
  3. Russo BC, Duncan JK, Goldberg MB. Topological Analysis of the Type 3 Secretion System Translocon Pore Protein IpaC following Its Native Delivery to the Plasma Membrane during Infection. mBio. 2019 05 28; 10(3). PMID: 31138750.
    Citations:    
  4. Bhattacharyya RP, Walker M, Boykin R, Son SS, Liu J, Hachey AC, Ma P, Wu L, Choi K, Cummins KC, Benson M, Skerry J, Ryu H, Wong SY, Goldberg MB, Han J, Pierce VM, Cosimi LA, Shoresh N, Livny J, Beechem J, Hung DT. Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA. Sci Rep. 2019 03 14; 9(1):4516. PMID: 30872641.
    Citations:    
  5. Miller KA, Garza-Mayers AC, Leung Y, Goldberg MB. Identification of interactions among host and bacterial proteins and evaluation of their role early during Shigella flexneri infection. Microbiology. 2018 04; 164(4):540-550. PMID: 29488864.
    Citations:    Fields:    
  6. Piantadosi A, Kanjilal S, Ganesh V, Khanna A, Hyle EP, Rosand J, Bold T, Metsky HC, Lemieux J, Leone MJ, Freimark L, Matranga CB, Adams G, McGrath G, Zamirpour S, Telford S, Rosenberg E, Cho T, Frosch MP, Goldberg MB, Mukerji SS, Sabeti PC. Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing. Clin Infect Dis. 2018 02 10; 66(5):789-792. PMID: 29020227.
    Citations: 1     Fields:    
  7. Piantadosi A, Mukerji SS, Chitneni P, Cho TA, Cosimi LA, Hung DT, Goldberg MB, Sabeti PC, Kuritzkes DR, Grad YH. Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis. Open Forum Infect Dis. 2017; 4(3):ofx138. PMID: 28761901.
    Citations: 1     
  8. Russo BC, Stamm LM, Raaben M, Kim CM, Kahoud E, Robinson LR, Bose S, Queiroz AL, Herrera BB, Baxt LA, Mor-Vaknin N, Fu Y, Molina G, Markovitz DM, Whelan SP, Goldberg MB. Intermediate filaments enable pathogen docking to trigger type 3 effector translocation. Nat Microbiol. 2016 Mar 07; 1:16025. PMID: 27572444.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Lu R, Herrera BB, Eshleman HD, Fu Y, Bloom A, Li Z, Sacks DB, Goldberg MB. Shigella Effector OspB Activates mTORC1 in a Manner That Depends on IQGAP1 and Promotes Cell Proliferation. PLoS Pathog. 2015 Oct; 11(10):e1005200. PMID: 26473364.
    Citations: 5     Fields:    Translation:HumansCells
  10. Lee SY, Gertler FB, Goldberg MB. Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery. Microbiology. 2015 Nov; 161(11):2149-60. PMID: 26358985.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Garza-Mayers AC, Miller KA, Russo BC, Nagda DV, Goldberg MB. Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop. mBio. 2015 Mar 03; 6(2):e02584. PMID: 25736891.
    Citations: 6     Fields:    Translation:HumansCells
  12. Yi CR, Allen JE, Russo B, Lee SY, Heindl JE, Baxt LA, Herrera BB, Kahoud E, MacBeath G, Goldberg MB. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. J Biol Chem. 2014 Oct 24; 289(43):30101-13. PMID: 25124035.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Baxt LA, Goldberg MB. Host and bacterial proteins that repress recruitment of LC3 to Shigella early during infection. PLoS One. 2014; 9(4):e94653. PMID: 24722587.
    Citations: 23     Fields:    Translation:HumansCells
  14. Gray AN, Li Z, Henderson-Frost J, Goldberg MB. Biogenesis of YidC cytoplasmic membrane substrates is required for positioning of autotransporter IcsA at future poles. J Bacteriol. 2014 Feb; 196(3):624-32. PMID: 24272775.
    Citations: 4     Fields:    Translation:Cells
  15. Li Z, Boyd D, Reindl M, Goldberg MB. Identification of YidC residues that define interactions with the Sec Apparatus. J Bacteriol. 2014 Jan; 196(2):367-77. PMID: 24187090.
    Citations: 4     Fields:    Translation:Cells
  16. Baxt LA, Garza-Mayers AC, Goldberg MB. Bacterial subversion of host innate immune pathways. Science. 2013 May 10; 340(6133):697-701. PMID: 23661751.
    Citations: 57     Fields:    Translation:HumansCells
  17. Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ. The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium. Cell Host Microbe. 2012 Dec 13; 12(6):778-90. PMID: 23245322.
    Citations: 73     Fields:    Translation:HumansCells
  18. Gray AN, Henderson-Frost JM, Boyd D, Sharafi S, Niki H, Goldberg MB. Unbalanced Charge Distribution as a Determinant for Dependence of a Subset of Escherichia coli Membrane Proteins on the Membrane Insertase YidC. MBio. 2012; 3(6). PMID: 23188509.
    Citations:    
  19. Fixen KR, Janakiraman A, Garrity S, Slade DJ, Gray AN, Karahan N, Hochschild A, Goldberg MB. Genetic reporter system for positioning of proteins at the bacterial pole. mBio. 2012; 3(2). PMID: 22375072.
    Citations: 3     Fields:    Translation:Cells
  20. Gray AN, Henderson-Frost JM, Boyd D, Sharafi S, Shirafi S, Niki H, Goldberg MB. Unbalanced charge distribution as a determinant for dependence of a subset of Escherichia coli membrane proteins on the membrane insertase YidC. mBio. 2011; 2(6). PMID: 22108384.
    Citations: 8     Fields:    Translation:Cells
  21. Stamm LM, Goldberg MB. Microbiology. Establishing the secretion hierarchy. Science. 2011 Mar 04; 331(6021):1147-8. PMID: 21385706.
    Citations: 9     Fields:    Translation:Cells
  22. Jehl SP, Doling AM, Giddings KS, Phalipon A, Sansonetti PJ, Goldberg MB, Starnbach MN. Antigen-specific CD8(+) T cells fail to respond to Shigella flexneri. Infect Immun. 2011 May; 79(5):2021-30. PMID: 21357720.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Stamm LM, Heller DM, Goldberg MB. Caging targets for destruction. Cell Host Microbe. 2010 Nov 18; 8(5):391-3. PMID: 21075349.
    Citations:    Fields:    
  24. Baxt LA, Goldberg MB. Anaerobic environment of the intestine primes pathogenic Shigella for infection. Expert Rev Anti Infect Ther. 2010 Nov; 8(11):1225-9. PMID: 21073287.
    Citations: 1     Fields:    
  25. Lu R, Goldberg MB. Bacterial exploitation of host cell signaling. Sci Transl Med. 2010 Sep 29; 2(51):51ps48. PMID: 20881278.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  26. Heindl JE, Saran I, Yi CR, Lesser CF, Goldberg MB. Requirement for formin-induced actin polymerization during spread of Shigella flexneri. Infect Immun. 2010 Jan; 78(1):193-203. PMID: 19841078.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  27. Janakiraman A, Fixen KR, Gray AN, Niki H, Goldberg MB. A genome-scale proteomic screen identifies a role for DnaK in chaperoning of polar autotransporters in Shigella. J Bacteriol. 2009 Oct; 191(20):6300-11. PMID: 19684128.
    Citations: 9     Fields:    Translation:Cells
  28. Yi CR, Goldberg MB. Enterohemorrhagic Escherichia coli raises the I-BAR. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6431-2. PMID: 19380713.
    Citations: 3     Fields:    Translation:HumansCells
  29. Yi CR, Goldberg MB. Putting enterohemorrhagic E. coli on a pedestal. Cell Host Microbe. 2009 Mar 19; 5(3):215-7. PMID: 19286129.
    Citations: 1     Fields:    Translation:Cells
  30. Wagner JK, Heindl JE, Gray AN, Jain S, Goldberg MB. Contribution of the periplasmic chaperone Skp to efficient presentation of the autotransporter IcsA on the surface of Shigella flexneri. J Bacteriol. 2009 Feb; 191(3):815-21. PMID: 19047350.
    Citations: 31     Fields:    Translation:Cells
  31. Germane KL, Ohi R, Goldberg MB, Spiller BW. Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules. Biochemistry. 2008 Sep 30; 47(39):10241-3. PMID: 18763811.
    Citations: 12     Fields:    Translation:HumansCells
  32. Goldman SR, Tu Y, Goldberg MB. Differential regulation by magnesium of the two MsbB paralogs of Shigella flexneri. J Bacteriol. 2008 May; 190(10):3526-37. PMID: 18359815.
    Citations: 11     Fields:    Translation:Cells
  33. Edgar R, Rokney A, Feeney M, Semsey S, Kessel M, Goldberg MB, Adhya S, Oppenheim AB. Bacteriophage infection is targeted to cellular poles. Mol Microbiol. 2008 Jun; 68(5):1107-16. PMID: 18363799.
    Citations: 29     Fields:    Translation:Cells
  34. Leung Y, Ally S, Goldberg MB. Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibition. Cell Host Microbe. 2008 Jan 17; 3(1):39-47. PMID: 18191793.
    Citations: 25     Fields:    Translation:HumansCells
  35. Jain S, Goldberg MB. Requirement for YaeT in the outer membrane assembly of autotransporter proteins. J Bacteriol. 2007 Jul; 189(14):5393-8. PMID: 17513479.
    Citations: 44     Fields:    Translation:Cells
  36. Pradel N, Santini CL, Bernadac A, Shih YL, Goldberg MB, Wu LF. Polar positional information in Escherichia coli spherical cells. Biochem Biophys Res Commun. 2007 Feb 09; 353(2):493-500. PMID: 17188233.
    Citations: 6     Fields:    Translation:Cells
  37. Jain S, van Ulsen P, Benz I, Schmidt MA, Fernandez R, Tommassen J, Goldberg MB. Polar localization of the autotransporter family of large bacterial virulence proteins. J Bacteriol. 2006 Jul; 188(13):4841-50. PMID: 16788193.
    Citations: 37     Fields:    Translation:Cells
  38. Nilsen T, Yan AW, Gale G, Goldberg MB. Presence of multiple sites containing polar material in spherical Escherichia coli cells that lack MreB. J Bacteriol. 2005 Sep; 187(17):6187-96. PMID: 16109960.
    Citations: 24     Fields:    Translation:Cells
  39. Wing HJ, Goldman SR, Ally S, Goldberg MB. Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus. Infect Immun. 2005 Feb; 73(2):1217-20. PMID: 15664968.
    Citations: 9     Fields:    Translation:Cells
  40. Janakiraman A, Goldberg MB. Recent advances on the development of bacterial poles. Trends Microbiol. 2004 Nov; 12(11):518-25. PMID: 15488393.
    Citations: 19     Fields:    Translation:Cells
  41. Nilsen T, Ghosh AS, Goldberg MB, Young KD. Branching sites and morphological abnormalities behave as ectopic poles in shape-defective Escherichia coli. Mol Microbiol. 2004 May; 52(4):1045-54. PMID: 15130123.
    Citations: 34     Fields:    Translation:Cells
  42. Ally S, Sauer NJ, Loureiro JJ, Snapper SB, Gertler FB, Goldberg MB. Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins. Cell Microbiol. 2004 Apr; 6(4):355-66. PMID: 15009027.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  43. Baron MJ, Bolduc GR, Goldberg MB, Aupérin TC, Madoff LC. Alpha C protein of group B Streptococcus binds host cell surface glycosaminoglycan and enters cells by an actin-dependent mechanism. J Biol Chem. 2004 Jun 04; 279(23):24714-23. PMID: 15044471.
    Citations: 27     Fields:    Translation:HumansCells
  44. Wing HJ, Yan AW, Goldman SR, Goldberg MB. Regulation of IcsP, the outer membrane protease of the Shigella actin tail assembly protein IcsA, by virulence plasmid regulators VirF and VirB. J Bacteriol. 2004 Feb; 186(3):699-705. PMID: 14729695.
    Citations: 17     Fields:    Translation:Cells
  45. Janakiraman A, Goldberg MB. Evidence for polar positional information independent of cell division and nucleoid occlusion. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):835-40. PMID: 14715903.
    Citations: 24     Fields:    Translation:Cells
  46. Brandon LD, Goehring N, Janakiraman A, Yan AW, Wu T, Beckwith J, Goldberg MB. IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributed. Mol Microbiol. 2003 Oct; 50(1):45-60. PMID: 14507362.
    Citations: 46     Fields:    Translation:Cells
  47. Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR. Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May; 71(5):2775-86. PMID: 12704152.
    Citations: 151     Fields:    Translation:Cells
  48. Magdalena J, Goldberg MB. Quantification of Shigella IcsA required for bacterial actin polymerization. Cell Motil Cytoskeleton. 2002 Apr; 51(4):187-96. PMID: 11977093.
    Citations: 9     Fields:    Translation:AnimalsCells
  49. Goldberg MB. Actin-based motility of intracellular microbial pathogens. Microbiol Mol Biol Rev. 2001 Dec; 65(4):595-626, table of contents. PMID: 11729265.
    Citations: 57     Fields:    Translation:HumansCells
  50. Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904. PMID: 11584271.
    Citations: 110     Fields:    Translation:AnimalsCells
  51. Robbins JR, Monack D, McCallum SJ, Vegas A, Pham E, Goldberg MB, Theriot JA. The making of a gradient: IcsA (VirG) polarity in Shigella flexneri. Mol Microbiol. 2001 Aug; 41(4):861-72. PMID: 11532149.
    Citations: 33     Fields:    Translation:Cells
  52. Charles M, Pérez M, Kobil JH, Goldberg MB. Polar targeting of Shigella virulence factor IcsA in Enterobacteriacae and Vibrio. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9871-6. PMID: 11481451.
    Citations: 48     Fields:    Translation:Cells
  53. Venkatesan MM, Goldberg MB, Rose DJ, Grotbeck EJ, Burland V, Blattner FR. Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri. Infect Immun. 2001 May; 69(5):3271-85. PMID: 11292750.
    Citations: 54     Fields:    Translation:HumansCells
  54. Brandon LD, Goldberg MB. Periplasmic transit and disulfide bond formation of the autotransported Shigella protein IcsA. J Bacteriol. 2001 Feb; 183(3):951-8. PMID: 11208794.
    Citations: 36     Fields:    Translation:Cells
  55. Way SS, Borczuk AC, Goldberg MB. Thymic independence of adaptive immunity to the intracellular pathogen Shigella flexneri serotype 2a. Infect Immun. 1999 Aug; 67(8):3970-9. PMID: 10417163.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  56. Way SS, Borczuk AC, Goldberg MB. Adaptive immune response to Shigella flexneri 2a cydC in immunocompetent mice and mice lacking immunoglobulin A. Infect Immun. 1999 Apr; 67(4):2001-4. PMID: 10085048.
    Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
  57. Steinhauer J, Agha R, Pham T, Varga AW, Goldberg MB. The unipolar Shigella surface protein IcsA is targeted directly to the bacterial old pole: IcsP cleavage of IcsA occurs over the entire bacterial surface. Mol Microbiol. 1999 Apr; 32(2):367-77. PMID: 10231492.
    Citations: 45     Fields:    Translation:Cells
  58. Way SS, Sallustio S, Magliozzo RS, Goldberg MB. Impact of either elevated or decreased levels of cytochrome bd expression on Shigella flexneri virulence. J Bacteriol. 1999 Feb; 181(4):1229-37. PMID: 9973350.
    Citations: 30     Fields:    Translation:AnimalsCells
  59. Charles M, Magdalena J, Theriot JA, Goldberg MB. Functional analysis of a rickettsial OmpA homology domain of Shigella flexneri icsA. J Bacteriol. 1999 Feb; 181(3):869-78. PMID: 9922250.
    Citations: 4     Fields:    Translation:AnimalsCells
  60. Way SS, Goldberg MB. Clearance of Shigella flexneri infection occurs through a nitric oxide-independent mechanism. Infect Immun. 1998 Jun; 66(6):3012-6. PMID: 9596784.
    Citations: 2     Fields:    Translation:AnimalsCells
  61. Way SS, Borczuk AC, Dominitz R, Goldberg MB. An essential role for gamma interferon in innate resistance to Shigella flexneri infection. Infect Immun. 1998 Apr; 66(4):1342-8. PMID: 9529051.
    Citations: 23     Fields:    Translation:AnimalsCells
  62. Shere KD, Sallustio S, Manessis A, D'Aversa TG, Goldberg MB. Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility. Mol Microbiol. 1997 Aug; 25(3):451-62. PMID: 9302008.
    Citations: 50     Fields:    Translation:Cells
  63. Goldberg MB. Shigella actin-based motility in the absence of vinculin. Cell Motil Cytoskeleton. 1997; 37(1):44-53. PMID: 9142438.
    Citations: 8     Fields:    Translation:Cells
  64. Sandlin RC, Goldberg MB, Maurelli AT. Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a. Mol Microbiol. 1996 Oct; 22(1):63-73. PMID: 8899709.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  65. Goldberg MB, Theriot JA. Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility. Proc Natl Acad Sci U S A. 1995 Jul 03; 92(14):6572-6. PMID: 7604035.
    Citations: 67     Fields:    Translation:AnimalsCells
  66. Sandlin RC, Lampel KA, Keasler SP, Goldberg MB, Stolzer AL, Maurelli AT. Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane. Infect Immun. 1995 Jan; 63(1):229-37. PMID: 7528731.
    Citations: 50     Fields:    Translation:HumansCells
  67. Goldberg MB, Theriot JA, Sansonetti PJ. Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent. Infect Immun. 1994 Dec; 62(12):5664-8. PMID: 7960150.
    Citations: 21     Fields:    Translation:AnimalsCells
  68. Goldberg MB. Cleavage of the Shigella surface protein IcsA (VirG): intention or accident? Trends Microbiol. 1994 Feb; 2(2):35-6; discussion 36-7. PMID: 8162437.
    Citations: 2     Fields:    Translation:HumansCells
  69. Goldberg MB, Sansonetti PJ. Shigella subversion of the cellular cytoskeleton: a strategy for epithelial colonization. Infect Immun. 1993 Dec; 61(12):4941-6. PMID: 8225568.
    Citations: 26     Fields:    Translation:HumansCells
  70. Goldberg MB, Barzu O, Parsot C, Sansonetti PJ. Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement. Infect Agents Dis. 1993 Aug; 2(4):210-1. PMID: 8173795.
    Citations: 17     Fields:    Translation:HumansCells
  71. Goldberg MB, Bârzu O, Parsot C, Sansonetti PJ. Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement. J Bacteriol. 1993 Apr; 175(8):2189-96. PMID: 8468279.
    Citations: 81     Fields:    Translation:HumansCells
  72. Goldberg MB, Boyko SA, Butterton JR, Stoebner JA, Payne SM, Calderwood SB. Characterization of a Vibrio cholerae virulence factor homologous to the family of TonB-dependent proteins. Mol Microbiol. 1992 Aug; 6(16):2407-18. PMID: 1406279.
    Citations: 33     Fields:    Translation:AnimalsCells
  73. Goldberg MB, Boyko SA, Calderwood SB. Positive transcriptional regulation of an iron-regulated virulence gene in Vibrio cholerae. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1125-9. PMID: 1705025.
    Citations: 60     Fields:    Translation:Cells
  74. Goldberg MB, Boyko SA, Calderwood SB. Transcriptional regulation by iron of a Vibrio cholerae virulence gene and homology of the gene to the Escherichia coli fur system. J Bacteriol. 1990 Dec; 172(12):6863-70. PMID: 2174861.
    Citations: 37     Fields:    Translation:Cells
  75. Calderwood SB, Acheson DW, Goldberg MB, Boyko SA, Donohue-Rolfe A. A system for production and rapid purification of large amounts of the Shiga toxin/Shiga-like toxin I B subunit. Infect Immun. 1990 Sep; 58(9):2977-82. PMID: 2201641.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  76. Pearson GD, DiRita VJ, Goldberg MB, Boyko SA, Calderwood SB, Mekalanos JJ. New attenuated derivatives of Vibrio cholerae. Res Microbiol. 1990 Sep-Oct; 141(7-8):893-9. PMID: 2101479.
    Citations: 9     Fields:    Translation:HumansCells
  77. Goldberg MB, DiRita VJ, Calderwood SB. Identification of an iron-regulated virulence determinant in Vibrio cholerae, using TnphoA mutagenesis. Infect Immun. 1990 Jan; 58(1):55-60. PMID: 2152889.
    Citations: 55     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.