Harvard Catalyst Profiles

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Sun Hur, Ph.D.

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The Hur laboratory investigates molecular mechanisms of self and non-self discrimination by the immune systems. The lab currently focuses on two topics: (1) the innate immune receptors involved in antiviral immune response, and (2) the transcription factors involved in T cell development of self tolerance. The lab uses a combination of structural biology, biochemistry and cell biology to identify molecular principles governing these key immunological processes. Visit http://hurlab.tch.harvard.edu/

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI154653 (HUR, SUN) Jul 1, 2020 - Jun 30, 2025
    Molecular mechanisms for antiviral signaling and regulation by MDA5 and TRIM65
    Role: Principal Investigator
  2. DP1AI152074 (HUR, SUN) Sep 30, 2019 - Jul 31, 2024
    Resolving functional aggregates: A new perspective on innate immune control
    Role: Principal Investigator
  3. R21AI147099 (HUR, SUN) Jun 10, 2019 - May 31, 2021
    Defining the molecular mechanism of Aire in T-cell tolerance
    Role: Principal Investigator
  4. R21AI130791 (HUR, SUN) Jan 20, 2017 - Dec 31, 2018
    Re-defining RIG-I-like helicases as viral RNA receptors with effector functions
    Role: Principal Investigator
  5. R21AI119880 (HUR, SUN) Jun 26, 2015 - May 31, 2017
    Interplays between ADAR1 and MDA5 in the pathogenesis of Aicardi-Goutière Syndrome
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Leng F, Zhang W, Ramirez RN, Leon J, Zhong Y, Hou L, Yuki K, van der Veeken J, Rudensky AY, Benoist C, Hur S. The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. Immunity. 2022 08 09; 55(8):1354-1369.e8. PMID: 35926508.
    Citations:    Fields:    Translation:Cells
  2. Huoh YS, Hur S. Death domain fold proteins in immune signaling and transcriptional regulation. FEBS J. 2022 07; 289(14):4082-4097. PMID: 33905163; PMCID: PMC8548401.
    Citations: 2     Fields:    Translation:Cells
  3. Ahmad S, Mu X, Hur S. The Role of RNA Editing in the Immune Response. Methods Mol Biol. 2021; 2181:287-307. PMID: 32729087.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S. Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Mol Cell. 2021 02 04; 81(3):599-613.e8. PMID: 33373584.
    Citations: 12     Fields:    Translation:HumansCells
  5. Wang HT, Hur S. Substrate recognition by TRIM and TRIM-like proteins in innate immunity. Semin Cell Dev Biol. 2021 03; 111:76-85. PMID: 33092958; PMCID: PMC7572318.
    Citations: 8     Fields:    Translation:HumansCells
  6. Huoh YS, Wu B, Park S, Yang D, Bansal K, Greenwald E, Wong WP, Mathis D, Hur S. Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance. Nat Commun. 2020 04 02; 11(1):1625. PMID: 32242017.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  7. Cadena C, Hur S. Filament-like Assemblies of Intracellular Nucleic Acid Sensors: Commonalities and Differences. Mol Cell. 2019 10 17; 76(2):243-254. PMID: 31626748; PMCID: PMC6880955.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, Chang HY. N6-Methyladenosine Modification Controls Circular RNA Immunity. Mol Cell. 2019 10 03; 76(1):96-109.e9. PMID: 31474572; PMCID: PMC6778039.
    Citations: 173     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  9. Jasenosky LD, Cadena C, Mire CE, Borisevich V, Haridas V, Ranjbar S, Nambu A, Bavari S, Soloveva V, Sadukhan S, Cassell GH, Geisbert TW, Hur S, Goldfeld AE. The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus. iScience. 2019 Sep 27; 19:1279-1290. PMID: 31402258.
    Citations: 44     
  10. Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park JW, Oh SW, Fujita T, Hou F, Binder M, Hur S. Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity. Cell. 2019 05 16; 177(5):1187-1200.e16. PMID: 31006531; PMCID: PMC6525047.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  11. Hur S. Double-Stranded RNA Sensors and Modulators in Innate Immunity. Annu Rev Immunol. 2019 04 26; 37:349-375. PMID: 30673536; PMCID: PMC7136661.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  12. Mu X, Greenwald E, Ahmad S, Hur S. An origin of the immunogenicity of in vitro transcribed RNA. Nucleic Acids Res. 2018 06 01; 46(10):5239-5249. PMID: 29534222; PMCID: PMC6007322.
    Citations: 34     Fields:    Translation:HumansCells
  13. Ahmad S, Mu X, Yang F, Greenwald E, Park JW, Jacob E, Zhang CZ, Hur S. Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation. Cell. 2018 02 08; 172(4):797-810.e13. PMID: 29395326.
    Citations: 132     Fields:    Translation:HumansCells
  14. Cadena C, Hur S. Antiviral Immunity and Circular RNA: No End in Sight. Mol Cell. 2017 Jul 20; 67(2):163-164. PMID: 28732203; PMCID: PMC6085925.
    Citations: 21     Fields:    Translation:Humans
  15. Sohn J, Hur S. Filament assemblies in foreign nucleic acid sensors. Curr Opin Struct Biol. 2016 Apr; 37:134-44. PMID: 26859869; PMCID: PMC5070476.
    Citations: 32     Fields:    Translation:AnimalsCells
  16. Wu B, Huoh YS, Hur S. Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors. Methods Mol Biol. 2016; 1390:131-42. PMID: 26803627; PMCID: PMC6122957.
    Citations: 5     Fields:    Translation:HumansCells
  17. Ahmad S, Hur S. Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors. Trends Biochem Sci. 2015 Oct; 40(10):576-585. PMID: 26410598; PMCID: PMC4584414.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  18. Wu B, Hur S. How RIG-I like receptors activate MAVS. Curr Opin Virol. 2015 Jun; 12:91-8. PMID: 25942693; PMCID: PMC4470786.
    Citations: 84     Fields:    Translation:HumansCells
  19. Yao H, Dittmann M, Peisley A, Hoffmann HH, Gilmore RH, Schmidt T, Schmidt-Burgk J, Hornung V, Rice CM, Hur S. ATP-dependent effector-like functions of RIG-I-like receptors. Mol Cell. 2015 May 07; 58(3):541-548. PMID: 25891073; PMCID: PMC4427555.
    Citations: 43     Fields:    Translation:HumansCells
  20. del Toro Duany Y, Wu B, Hur S. MDA5-filament, dynamics and disease. Curr Opin Virol. 2015 Jun; 12:20-5. PMID: 25676875.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  21. Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S. Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I. Mol Cell. 2014 Aug 21; 55(4):511-23. PMID: 25018021.
    Citations: 127     Fields:    Translation:Cells
  22. Rice GI, Del Toro Duany Y, Jenkinson EM, Forte GM, Anderson BH, Ariaudo G, Bader-Meunier B, Baildam EM, Battini R, Beresford MW, Casarano M, Chouchane M, Cimaz R, Collins AE, Cordeiro NJ, Dale RC, Davidson JE, De Waele L, Desguerre I, Faivre L, Fazzi E, Isidor B, Lagae L, Latchman AR, Lebon P, Li C, Livingston JH, Lourenço CM, Mancardi MM, Masurel-Paulet A, McInnes IB, Menezes MP, Mignot C, O'Sullivan J, Orcesi S, Picco PP, Riva E, Robinson RA, Rodriguez D, Salvatici E, Scott C, Szybowska M, Tolmie JL, Vanderver A, Vanhulle C, Vieira JP, Webb K, Whitney RN, Williams SG, Wolfe LA, Zuberi SM, Hur S, Crow YJ. Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling. Nat Genet. 2014 May; 46(5):503-509. PMID: 24686847; PMCID: PMC4004585.
    Citations: 242     Fields:    Translation:HumansCells
  23. Peisley A, Wu B, Xu H, Chen ZJ, Hur S. Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature. 2014 May 01; 509(7498):110-4. PMID: 24590070; PMCID: PMC6136653.
    Citations: 183     Fields:    Translation:HumansCells
  24. Peisley A, Wu B, Yao H, Walz T, Hur S. RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner. Mol Cell. 2013 Sep 12; 51(5):573-83. PMID: 23993742.
    Citations: 120     Fields:    Translation:HumansCells
  25. Wu B, Hur S. Viral counterattack against the host innate immune system. Cell Res. 2013 Jun; 23(6):735-6. PMID: 23478300.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  26. Wu B, Peisley A, Richards C, Yao H, Zeng X, Lin C, Chu F, Walz T, Hur S. Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell. 2013 Jan 17; 152(1-2):276-89. PMID: 23273991.
    Citations: 249     Fields:    Translation:HumansCells
  27. Peisley A, Jo MH, Lin C, Wu B, Orme-Johnson M, Walz T, Hohng S, Hur S. Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3340-9. PMID: 23129641.
    Citations: 73     Fields:    Translation:HumansCells
  28. Peisley A, Hur S. Multi-level regulation of cellular recognition of viral dsRNA. Cell Mol Life Sci. 2013 Jun; 70(11):1949-63. PMID: 22960755.
    Citations: 15     Fields:    Translation:Cells
  29. Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T, Hur S. Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21010-5. PMID: 22160685.
    Citations: 149     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.