Harvard Catalyst Profiles

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Sun Hur, Ph.D.

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Overview
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The Hur laboratory investigates molecular mechanisms of self and non-self discrimination by the immune systems. The lab currently focuses on two topics: (1) the innate immune receptors involved in antiviral immune response, and (2) the transcription factors involved in T cell development of self tolerance. The lab uses a combination of structural biology, biochemistry and cell biology to identify molecular principles governing these key immunological processes. Visit http://hurlab.tch.harvard.edu/
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI154653 (HUR, SUN) Jul 1, 2020 - Jun 30, 2025
    NIH/NIAID
    Molecular mechanisms for antiviral signaling and regulation by MDA5 and TRIM65
    Role: Principal Investigator
  2. DP1AI152074 (HUR, SUN) Sep 30, 2019 - Jul 31, 2024
    NIH/NIAID
    Resolving functional aggregates: A new perspective on innate immune control
    Role: Principal Investigator
  3. R21AI147099 (HUR, SUN) Jun 10, 2019 - May 31, 2021
    NIH/NIAID
    Defining the molecular mechanism of Aire in T-cell tolerance
    Role: Principal Investigator
  4. R21AI130791 (HUR, SUN) Jan 20, 2017 - Dec 31, 2018
    NIH/NIAID
    Re-defining RIG-I-like helicases as viral RNA receptors with effector functions
    Role: Principal Investigator
  5. R21AI119880 (HUR, SUN) Jun 26, 2015 - May 31, 2017
    NIH/NIAID
    Interplays between ADAR1 and MDA5 in the pathogenesis of Aicardi-Goutière Syndrome
    Role: Principal Investigator

Bibliographic
selected publications
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.