Title Oscar M. Schloss, MD Professor of Pediatrics, Professor of Biological Chemistry and Molecular Pharmacology Institution Boston Children's Hospital Address Children's Hospital C L S B 3095 3 Blackfan Circle Boston MA 02115
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Title
Oscar M. Schloss, MD Professor of Pediatrics
Institution
Boston Children's Hospital

Overview
The Hur laboratory investigates molecular mechanisms of self and non-self discrimination by the immune systems. The lab currently focuses on two topics: (1) the innate immune receptors involved in antiviral immune response, and (2) the transcription factors involved in T cell development of self tolerance. The lab uses a combination of structural biology, biochemistry and cell biology to identify molecular principles governing these key immunological processes. Visit http://hurlab.tch.harvard.edu/

Research
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R01AI154653
(HUR, SUN)
Jul 1, 2020 - Jun 30, 2025
Molecular mechanisms for antiviral signaling and regulation by MDA5 and TRIM65
Role: Principal Investigator
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DP1AI152074
(HUR, SUN)
Sep 30, 2019 - Jul 31, 2024
Resolving functional aggregates: A new perspective on innate immune control
Role: Principal Investigator
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R21AI147099
(HUR, SUN)
Jun 10, 2019 - May 31, 2021
Defining the molecular mechanism of Aire in T-cell tolerance
Role: Principal Investigator
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R21AI130791
(HUR, SUN)
Jan 20, 2017 - Dec 31, 2018
Re-defining RIG-I-like helicases as viral RNA receptors with effector functions
Role: Principal Investigator
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R21AI119880
(HUR, SUN)
Jun 26, 2015 - May 31, 2017
Interplays between ADAR1 and MDA5 in the pathogenesis of Aicardi-Goutière Syndrome
Role: Principal Investigator
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R01AI111784
(HUR, SUN)
Sep 17, 2014 - Aug 31, 2024
Molecular mechanism of RIG-I and RIPLET in antiviral signaling
Role: Principal Investigator
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R01AI106912
(HUR, SUN)
May 15, 2014 - Apr 30, 2019
Molecular Mechanisms for Antiviral Signal Activation by MDA5 and RIG-I
Role: Principal Investigator

Bibliographic
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