Harvard Catalyst Profiles

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Dennis Brown, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK121848 (BROWN, DENNIS) Sep 1, 2019 - Jun 30, 2024
    NIH/NIDDK
    Defining protein:protein interactions for the regulation of renal V-ATPase function: role in expression, assembly and trafficking.
    Role: Principal Investigator
  2. S10OD021577 (BROWN, DENNIS) Apr 1, 2016 - Mar 31, 2017
    NIH
    A Zeiss LSM800 confocal microscope with Airyscan
    Role: Principal Investigator
  3. R01DK096586 (BROWN, DENNIS) Sep 20, 2012 - Aug 31, 2021
    NIH/NIDDK
    Cell biology of vasopressin-induced water channels
    Role: Principal Investigator
  4. S10RR031563 (BROWN, DENNIS) Apr 1, 2011 - Mar 31, 2012
    NIH/NCRR
    A Nikon A1R Confocal Microscope System
    Role: Principal Investigator
  5. S10RR022602 (BROWN, DENNIS) Apr 1, 2006 - Mar 31, 2007
    NIH/NCRR
    An MMi CellCut Laser Mircrodissection System
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cheung PW, Bouley R, Brown D. Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit. Annu Rev Pharmacol Toxicol. 2020 01 06; 60:175-194. PMID: 31561739.
    Citations:    
  2. Brown D, Lu HA. Aquaporin-2 inhibitors: fishing in the chemical pool. J Am Soc Nephrol. 2013 Apr; 24(5):685-6. PMID: 23599384.
    Citations:    Fields:    Translation:HumansAnimals
  3. Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D. Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel. Am J Physiol Cell Physiol. 2013 Jan 01; 304(1):C38-48. PMID: 23015545.
    Citations: 21     Fields:    Translation:AnimalsCells
  4. Brown D, Bouley R, Paunescu TG, Breton S, Lu HA. New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells. Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1421-33. PMID: 22460710.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  5. Brown D, Wagner CA. Molecular mechanisms of acid-base sensing by the kidney. J Am Soc Nephrol. 2012 May; 23(5):774-80. PMID: 22362904.
    Citations: 23     Fields:    Translation:HumansAnimals
  6. Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R. Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand. Endocrinology. 2011 Oct; 152(10):3893-904. PMID: 21828182.
    Citations: 4     Fields:    Translation:AnimalsCells
  7. Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA. Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase. Am J Physiol Renal Physiol. 2011 Aug; 301(2):F309-18. PMID: 21511701.
    Citations: 29     Fields:    Translation:AnimalsCells
  8. Shum WW, Da Silva N, Belleannée C, McKee M, Brown D, Breton S. Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells. Am J Physiol Cell Physiol. 2011 Jul; 301(1):C31-43. PMID: 21411727.
    Citations: 15     Fields:    Translation:AnimalsCells
  9. Da Silva N, Cortez-Retamozo V, Reinecker HC, Wildgruber M, Hill E, Brown D, Swirski FK, Pittet MJ, Breton S. A dense network of dendritic cells populates the murine epididymis. Reproduction. 2011 May; 141(5):653-63. PMID: 21310816.
    Citations: 25     Fields:    Translation:AnimalsCells
  10. Merkulova M, Hurtado-Lorenzo A, Hosokawa H, Zhuang Z, Brown D, Ausiello DA, Marshansky V. Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution. Am J Physiol Cell Physiol. 2011 Jun; 300(6):C1442-55. PMID: 21307348.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Bouley R, Lu HA, Nunes P, Da Silva N, McLaughlin M, Chen Y, Brown D. Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration. J Am Soc Nephrol. 2011 Jan; 22(1):59-72. PMID: 21071524.
    Citations: 24     Fields:    Translation:AnimalsCells
  12. Zhuang Z, Marshansky V, Breton S, Brown D. Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F199-206. PMID: 20980408.
    Citations: 15     Fields:    Translation:AnimalsCells
  13. Miranda KC, Bond DT, McKee M, Skog J, Paunescu TG, Da Silva N, Brown D, Russo LM. Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease. Kidney Int. 2010 Jul; 78(2):191-9. PMID: 20428099.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  14. Miranda KC, Karet FE, Brown D. An extended nomenclature for mammalian V-ATPase subunit genes and splice variants. PLoS One. 2010 Mar 10; 5(3):e9531. PMID: 20224822.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  15. Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77. PMID: 20167703.
    Citations: 15     Fields:    Translation:AnimalsCells
  16. Belleannée C, Da Silva N, Shum WW, Brown D, Breton S. Role of purinergic signaling pathways in V-ATPase recruitment to apical membrane of acidifying epididymal clear cells. Am J Physiol Cell Physiol. 2010 Apr; 298(4):C817-30. PMID: 20071692.
    Citations: 19     Fields:    Translation:AnimalsCells
  17. Paunescu TG, Ljubojevic M, Russo LM, Winter C, McLaughlin MM, Wagner CA, Breton S, Brown D. cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F643-54. PMID: 20053793.
    Citations: 57     Fields:    Translation:AnimalsCells
  18. Pastor-Soler NM, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S. Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones. Reproduction. 2010 Mar; 139(3):613-21. PMID: 19948840.
    Citations: 9     Fields:    Translation:Animals
  19. Bouley R, Palomino Z, Tang SS, Nunes P, Kobori H, Lu HA, Shum WW, Sabolic I, Brown D, Ingelfinger JR, Jung FF. Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1575-86. PMID: 19776169.
    Citations: 10     Fields:    Translation:AnimalsCells
  20. Brown D, Paunescu TG, Breton S, Marshansky V. Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking. J Exp Biol. 2009 Jun; 212(Pt 11):1762-72. PMID: 19448085.
    Citations: 46     Fields:    Translation:AnimalsCells
  21. Shum WW, Da Silva N, Brown D, Breton S. Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk. J Exp Biol. 2009 Jun; 212(Pt 11):1753-61. PMID: 19448084.
    Citations: 42     Fields:    Translation:AnimalsCells
  22. Brown D, Breton S, Ausiello DA, Marshansky V. Sensing, signaling and sorting events in kidney epithelial cell physiology. Traffic. 2009 Mar; 10(3):275-84. PMID: 19170982.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  23. Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D. Impaired tubular uptake explains albuminuria in early diabetic nephropathy. J Am Soc Nephrol. 2009 Mar; 20(3):489-94. PMID: 19118149.
    Citations: 70     Fields:    Translation:Animals
  24. Shum WW, Da Silva N, McKee M, Smith PJ, Brown D, Breton S. Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia. Cell. 2008 Dec 12; 135(6):1108-17. PMID: 19070580.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  25. Belleannée C, Da Silva N, Shum WW, Marsolais M, Laprade R, Brown D, Breton S. Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9. Biol Reprod. 2009 Jan; 80(1):134-43. PMID: 18829705.
    Citations: 7     Fields:    Translation:AnimalsCells
  26. Nunes P, Hasler U, McKee M, Lu HA, Bouley R, Brown D. A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2. Am J Physiol Cell Physiol. 2008 Dec; 295(6):C1476-87. PMID: 18799651.
    Citations: 16     Fields:    Translation:AnimalsCells
  27. Brown D, Hasler U, Nunes P, Bouley R, Lu HA. Phosphorylation events and the modulation of aquaporin 2 cell surface expression. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):491-8. PMID: 18695390.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  28. Paunescu TG, Jones AC, Tyszkowski R, Brown D. V-ATPase expression in the mouse olfactory epithelium. Am J Physiol Cell Physiol. 2008 Oct; 295(4):C923-30. PMID: 18667600.
    Citations: 15     Fields:    Translation:AnimalsCells
  29. Hasler U, Nunes P, Bouley R, Lu HA, Matsuzaki T, Brown D. Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells. J Biol Chem. 2008 Sep 26; 283(39):26643-61. PMID: 18664568.
    Citations: 24     Fields:    Translation:AnimalsCells
  30. Brown D. Aquaporins and vasopressin signaling in kidney health and disease: introduction. Semin Nephrol. 2008 May; 28(3):215-6. PMID: 18519082.
    Citations:    Fields:    Translation:HumansCells
  31. Bouley R, Hasler U, Lu HA, Nunes P, Brown D. Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus. Semin Nephrol. 2008 May; 28(3):266-78. PMID: 18519087.
    Citations: 27     Fields:    Translation:HumansCells
  32. Lu HJ, Matsuzaki T, Bouley R, Hasler U, Qin QH, Brown D. The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F290-4. PMID: 18434387.
    Citations: 39     Fields:    Translation:AnimalsCells
  33. Lu L, Bao Y, Khan A, Goldstein AM, Newburg DS, Quaroni A, Brown D, Walker WA. Hydrocortisone modulates cholera toxin endocytosis by regulating immature enterocyte plasma membrane phospholipids. Gastroenterology. 2008 Jul; 135(1):185-193.e1. PMID: 18456000.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  34. Russo LM, Brown D, Lin HY. The soluble transforming growth factor-beta receptor: advantages and applications. Int J Biochem Cell Biol. 2009 Mar; 41(3):472-6. PMID: 18339576.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  35. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 01; 283(5):2986-96. PMID: 18055461.
    Citations: 22     Fields:    Translation:AnimalsCells
  36. Paunescu TG, Da Silva N, Russo LM, McKee M, Lu HA, Breton S, Brown D. Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Am J Physiol Renal Physiol. 2008 Jan; 294(1):F130-8. PMID: 17959750.
    Citations: 41     Fields:    Translation:AnimalsCells
  37. Paunescu TG, Russo LM, Da Silva N, Kovacikova J, Mohebbi N, Van Hoek AN, McKee M, Wagner CA, Breton S, Brown D. Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice. Am J Physiol Renal Physiol. 2007 Dec; 293(6):F1915-26. PMID: 17898041.
    Citations: 33     Fields:    Translation:AnimalsCells
  38. Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD. Controversies in nephrology: response to 'renal albumin handling, facts, and artifacts'. Kidney Int. 2007 Nov; 72(10):1195-7. PMID: 17851467.
    Citations: 7     Fields:    Translation:AnimalsCells
  39. Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007 Sep 28; 282(39):28721-32. PMID: 17636261.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  40. Da Silva N, Shum WW, El-Annan J, Paunescu TG, McKee M, Smith PJ, Brown D, Breton S. Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit. Am J Physiol Cell Physiol. 2007 Jul; 293(1):C199-210. PMID: 17392376.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  41. Russo LM, del Re E, Brown D, Lin HY. Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor. Diabetes. 2007 Feb; 56(2):380-8. PMID: 17259382.
    Citations: 35     Fields:    Translation:AnimalsCells
  42. Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int. 2007 Mar; 71(6):504-13. PMID: 17228368.
    Citations: 115     Fields:    Translation:Animals
  43. Breton S, Brown D. New insights into the regulation of V-ATPase-dependent proton secretion. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F1-10. PMID: 17032935.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  44. Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K. In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett. 2006 Oct; 6(10):2225-31. PMID: 17034088.
    Citations: 33     Fields:    Translation:AnimalsCells
  45. Da Silva N, Piétrement C, Brown D, Breton S. Segmental and cellular expression of aquaporins in the male excurrent duct. Biochim Biophys Acta. 2006 Aug; 1758(8):1025-33. PMID: 16935257.
    Citations: 11     Fields:    Translation:Animals
  46. Bouley R, Hawthorn G, Russo LM, Lin HY, Ausiello DA, Brown D. Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell. 2006 Apr; 98(4):215-32. PMID: 16563128.
    Citations: 22     Fields:    Translation:AnimalsCells
  47. Brown D. Imaging protein trafficking. Nephron Exp Nephrol. 2006; 103(2):e55-61. PMID: 16543765.
    Citations: 2     Fields:    Translation:Animals
  48. Russo LM, McKee M, Brown D. Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney. Am J Physiol Renal Physiol. 2006 Jul; 291(1):F246-53. PMID: 16449354.
    Citations: 23     Fields:    Translation:AnimalsCells
  49. Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V. V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. Nat Cell Biol. 2006 Feb; 8(2):124-36. PMID: 16415858.
    Citations: 148     Fields:    Translation:HumansAnimalsCells
  50. Da Silva N, Silberstein C, Beaulieu V, Piétrement C, Van Hoek AN, Brown D, Breton S. Postnatal expression of aquaporins in epithelial cells of the rat epididymis. Biol Reprod. 2006 Feb; 74(2):427-38. PMID: 16221990.
    Citations: 16     Fields:    Translation:AnimalsCells
  51. Pietrement C, Sun-Wada GH, Silva ND, McKee M, Marshansky V, Brown D, Futai M, Breton S. Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis. Biol Reprod. 2006 Jan; 74(1):185-94. PMID: 16192400.
    Citations: 55     Fields:    Translation:Animals
  52. Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13616-21. PMID: 16174750.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  53. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. PMID: 16169464.
    Citations: 120     Fields:    Translation:Animals
  54. Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005 Jul; 37(7):739-44. PMID: 15924139.
    Citations: 251     Fields:    Translation:HumansCells
  55. Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA. Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1390-401. PMID: 15677378.
    Citations: 16     Fields:    Translation:AnimalsCells
  56. Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12. PMID: 15644488.
    Citations: 40     Fields:    Translation:AnimalsCells
  57. Miller RL, Zhang P, Smith M, Beaulieu V, Paunescu TG, Brown D, Breton S, Nelson RD. V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice. Am J Physiol Cell Physiol. 2005 May; 288(5):C1134-44. PMID: 15634743.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  58. Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 04; 280(9):8452-63. PMID: 15591047.
    Citations: 40     Fields:    Translation:AnimalsCells
  59. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Renal vacuolar H+-ATPase. Physiol Rev. 2004 Oct; 84(4):1263-314. PMID: 15383652.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  60. Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP. Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14877-82. PMID: 15465913.
    Citations: 47     Fields:    Translation:AnimalsCells
  61. Paredes AM, Ferreira D, Horton M, Saad A, Tsuruta H, Johnston R, Klimstra W, Ryman K, Hernandez R, Chiu W, Brown DT. Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion. Virology. 2004 Jul 01; 324(2):373-86. PMID: 15207623.
    Citations: 29     Fields:    Translation:AnimalsCells
  62. Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11. PMID: 15149973.
    Citations: 40     Fields:    Translation:AnimalsCells
  63. Fujita Y, Terashima M, Kakuta T, Itoh J, Tokimasa T, Brown D, Saito A. Transcellular water transport and stability of expression in aquaporin 1-transfected LLC-PK1 cells in the development of a portable bioartificial renal tubule device. Tissue Eng. 2004 May-Jun; 10(5-6):711-22. PMID: 15265288.
    Citations: 4     Fields:    Translation:AnimalsCells
  64. Paunescu TG, Da Silva N, Marshansky V, McKee M, Breton S, Brown D. Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C149-62. PMID: 15013950.
    Citations: 33     Fields:    Translation:Animals
  65. El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. Am J Physiol Cell Physiol. 2004 Apr; 286(4):C768-78. PMID: 14684384.
    Citations: 10     Fields:    Translation:AnimalsCells
  66. Smith AN, Lovering RC, Futai M, Takeda J, Brown D, Karet FE. Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes. Mol Cell. 2003 Oct; 12(4):801-3. PMID: 14580332.
    Citations: 16     Fields:    Translation:HumansAnimals
  67. Lu H, Sun TX, Bouley R, Blackburn K, McLaughlin M, Brown D. Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2. Am J Physiol Renal Physiol. 2004 Feb; 286(2):F233-43. PMID: 14519593.
    Citations: 49     Fields:    Translation:AnimalsCells
  68. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 05; 278(49):49523-9. PMID: 14512417.
    Citations: 97     Fields:    Translation:AnimalsCells
  69. Ba J, Brown D, Friedman PA. Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1233-43. PMID: 12952858.
    Citations: 32     Fields:    Translation:AnimalsCells
  70. Pearson AM, Baksa K, Rämet M, Protas M, McKee M, Brown D, Ezekowitz RA. Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Microbes Infect. 2003 Aug; 5(10):815-24. PMID: 12919849.
    Citations: 26     Fields:    Translation:AnimalsCells
  71. Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol. 2003 Jun 17; 13(12):1070-4. PMID: 12814555.
    Citations: 102     Fields:    Translation:AnimalsCells
  72. Bouley R, Sun TX, Chenard M, McLaughlin M, McKee M, Lin HY, Brown D, Ausiello DA. Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C750-62. PMID: 12801889.
    Citations: 21     Fields:    Translation:AnimalsCells
  73. Wagner CA, Lükewille U, Valles P, Breton S, Brown D, Giebisch GH, Geibel JP. A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. Pflugers Arch. 2003 Aug; 446(5):623-32. PMID: 12748863.
    Citations: 16     Fields:    Translation:Animals
  74. Brown D. The ins and outs of aquaporin-2 trafficking. Am J Physiol Renal Physiol. 2003 May; 284(5):F893-901. PMID: 12676734.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  75. Isnard-Bagnis C, Da Silva N, Beaulieu V, Yu AS, Brown D, Breton S. Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C220-32. PMID: 12475763.
    Citations: 16     Fields:    Translation:AnimalsCells
  76. Zharkikh L, Zhu X, Stricklett PK, Kohan DE, Chipman G, Breton S, Brown D, Nelson RD. Renal principal cell-specific expression of green fluorescent protein in transgenic mice. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1351-64. PMID: 12426236.
    Citations: 11     Fields:    Translation:AnimalsCells
  77. Sabolic I, Ljubojevic M, Herak-Kramberger CM, Brown D. Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1389-402. PMID: 12426237.
    Citations: 6     Fields:    Translation:AnimalsCells
  78. van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7. PMID: 12374804.
    Citations: 24     Fields:    Translation:AnimalsCells
  79. Marshansky V, Ausiello DA, Brown D. Physiological importance of endosomal acidification: potential role in proximal tubulopathies. Curr Opin Nephrol Hypertens. 2002 Sep; 11(5):527-37. PMID: 12187318.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  80. Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22. PMID: 12021052.
    Citations: 18     Fields:    Translation:AnimalsCells
  81. Sun TX, Van Hoek A, Huang Y, Bouley R, McLaughlin M, Brown D. Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F998-1011. PMID: 11997316.
    Citations: 45     Fields:    Translation:AnimalsCells
  82. Christmas P, Weber BM, McKee M, Brown D, Soberman RJ. Membrane localization and topology of leukotriene C4 synthase. J Biol Chem. 2002 Aug 09; 277(32):28902-8. PMID: 12023288.
    Citations: 12     Fields:    Translation:AnimalsCells
  83. Sabolic I, Herak-Kramberger CM, Ljubojevic M, Biemesderfer D, Brown D. NHE3 and NHERF are targeted to the basolateral membrane in proximal tubules of colchicine-treated rats. Kidney Int. 2002 Apr; 61(4):1351-64. PMID: 11918742.
    Citations: 7     Fields:    Translation:AnimalsCells
  84. Breton S, Inoue T, Knepper MA, Brown D. Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia. Am J Physiol Renal Physiol. 2002 Mar; 282(3):F523-9. PMID: 11832435.
    Citations: 6     Fields:    Translation:AnimalsCells
  85. Cario E, Brown D, McKee M, Lynch-Devaney K, Gerken G, Podolsky DK. Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am J Pathol. 2002 Jan; 160(1):165-73. PMID: 11786410.
    Citations: 66     Fields:    Translation:HumansCells
  86. Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):14-20. PMID: 11731004.
    Citations: 2     Fields:    Translation:HumansCells
  87. Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D. Aquaporin 9 expression along the male reproductive tract. Biol Reprod. 2001 Aug; 65(2):384-93. PMID: 11466204.
    Citations: 34     Fields:    Translation:AnimalsCells
  88. Herak-Kramberger CM, Breton S, Brown D, Kraus O, Sabolic I. Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract. Biol Reprod. 2001 Jun; 64(6):1699-707. PMID: 11369598.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  89. Herak-Kramberger CM, Sabolic I, Blanusa M, Smith PJ, Brown D, Breton S. Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis. Biol Reprod. 2000 Aug; 63(2):599-606. PMID: 10906070.
    Citations: 8     Fields:    Translation:AnimalsCells
  90. Breton S, Nsumu NN, Galli T, Sabolic I, Smith PJ, Brown D. Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract. Am J Physiol Renal Physiol. 2000 May; 278(5):F717-25. PMID: 10807583.
    Citations: 17     Fields:    Translation:AnimalsCells
  91. Baus M, Medjugorac-Popovski M, Brown D, Sabolic I, Mirela B, Mila MP, Ivan S. In colchicine-treated rats, cellular distribution of AQP-1 in convoluted and straight proximal tubule segments is differently affected. Pflugers Arch. 2000 Jan; 439(3):321-30. PMID: 10650984.
    Citations: 4     Fields:    Translation:AnimalsCells
  92. Sabolic I, Herak-Kramberger CM, Breton S, Brown D. Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval. J Am Soc Nephrol. 1999 May; 10(5):913-22. PMID: 10232676.
    Citations: 14     Fields:    Translation:Animals
  93. Breton S, Tyszkowski R, Sabolic I, Brown D. Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis. Histochem Cell Biol. 1999 Feb; 111(2):97-105. PMID: 10090570.
    Citations: 14     Fields:    Translation:Animals
  94. Herak-Kramberger CM, Brown D, Sabolic I. Cadmium inhibits vacuolar H(+)-ATPase and endocytosis in rat kidney cortex. Kidney Int. 1998 Jun; 53(6):1713-26. PMID: 9607204.
    Citations: 8     Fields:    Translation:AnimalsCells
  95. Sabolic I, Brown D, Gluck SL, Alper SL. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37. PMID: 8995726.
    Citations: 26     Fields:    Translation:Animals
  96. Brown D, Sabolic I, Breton S. Polarized expression of membrane proteins in renal epithelial cells: involvement of specialized transport vesicles and intracellular pathways. Adv Nephrol Necker Hosp. 1997; 27:297-315. PMID: 9408453.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  97. Sabolic I, Brown D, Barckhardt T. Ecto-ATPase activity and labeling with the anti-ecto-ATPase antibody in renal brush border do not coincide. Am J Physiol. 1996 Nov; 271(5 Pt 2):F1100-1. PMID: 8946006.
    Citations:    Fields:    Translation:HumansAnimalsCells
  98. Brown D, Katsura T, Kawashima M, Verkman AS, Sabolic I. Cellular distribution of the aquaporins: a family of water channel proteins. Histochem Cell Biol. 1995 Jul; 104(1):1-9. PMID: 7584554.
    Citations: 13     Fields:    Translation:HumansAnimals
  99. Schweickhardt C, Sabolic I, Brown D, Burckhardt G. Ecto-adenosinetriphosphatase in rat small intestinal brush-border membranes. Am J Physiol. 1995 Apr; 268(4 Pt 1):G663-72. PMID: 7733291.
    Citations: 3     Fields:    Translation:AnimalsCells
  100. Bachinsky DR, Sabolic I, Emmanouel DS, Jefferson DM, Carone FA, Brown D, Perrone RD. Water channel expression in human ADPKD kidneys. Am J Physiol. 1995 Mar; 268(3 Pt 2):F398. PMID: 7535000.
    Citations: 5     Fields:    Translation:HumansCells
  101. Sabolic I, Katsura T, Verbavatz JM, Brown D. The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats. J Membr Biol. 1995 Feb; 143(3):165-75. PMID: 7539496.
    Citations: 36     Fields:    Translation:AnimalsCells
  102. Valenti G, Verbavatz JM, Sabolic I, Ausiello DA, Verkman AS, Brown D. A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells. Am J Physiol. 1994 Sep; 267(3 Pt 1):C812-20. PMID: 7524336.
    Citations: 5     Fields:    Translation:AnimalsCells
  103. Sabolic I, Brown D. Water transport in renal tubules is mediated by aquaporins. Clin Investig. 1994 Sep; 72(9):698-700. PMID: 7531521.
    Citations: 1     Fields:    Translation:HumansAnimals
  104. Sabolic I, Brown D, Verbavatz JM, Kleinman J. H(+)-ATPases of renal cortical and medullary endosomes are differentially sensitive to Sch-28080 and omeprazole. Am J Physiol. 1994 Jun; 266(6 Pt 2):F868-77. PMID: 7517642.
    Citations: 7     Fields:    Translation:AnimalsCells
  105. Verbavatz JM, Van Hoek AN, Ma T, Sabolic I, Valenti G, Ellisman MH, Ausiello DA, Verkman AS, Brown D. A 28 kDa sarcolemmal antigen in kidney principal cell basolateral membranes: relationship to orthogonal arrays and MIP26. J Cell Sci. 1994 Apr; 107 ( Pt 4):1083-94. PMID: 7520041.
    Citations: 5     Fields:    Translation:AnimalsCells
  106. Verbavatz JM, Brown D, Sabolic I, Valenti G, Ausiello DA, Van Hoek AN, Ma T, Verkman AS. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. J Cell Biol. 1993 Nov; 123(3):605-18. PMID: 7693713.
    Citations: 50     Fields:    Translation:AnimalsCells
  107. Brown D, Verbavatz JM, Valenti G, Lui B, Sabolic I. Localization of the CHIP28 water channel in reabsorptive segments of the rat male reproductive tract. Eur J Cell Biol. 1993 Aug; 61(2):264-73. PMID: 8223717.
    Citations: 18     Fields:    Translation:AnimalsCells
  108. Brown D, Sabolic I. Endosomal pathways for water channel and proton pump recycling in kidney epithelial cells. J Cell Sci Suppl. 1993; 17:49-59. PMID: 8144705.
    Citations: 6     Fields:    Translation:AnimalsCells
  109. Sabolic I, Valenti G, Verbavatz JM, Van Hoek AN, Verkman AS, Ausiello DA, Brown D. Localization of the CHIP28 water channel in rat kidney. Am J Physiol. 1992 Dec; 263(6 Pt 1):C1225-33. PMID: 1282299.
    Citations: 55     Fields:    Translation:Animals
  110. Brown D, Sabolic I, Gluck S. Polarized targeting of V-ATPase in kidney epithelial cells. J Exp Biol. 1992 Nov; 172:231-43. PMID: 1491226.
    Citations: 11     Fields:    Translation:AnimalsCells
  111. Sabolic I, Wuarin F, Shi LB, Verkman AS, Ausiello DA, Gluck S, Brown D. Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase. J Cell Biol. 1992 Oct; 119(1):111-22. PMID: 1388176.
    Citations: 8     Fields:    Translation:AnimalsCells
  112. Brown D, Lui B, Gluck S, Sabolic I. A plasma membrane proton ATPase in specialized cells of rat epididymis. Am J Physiol. 1992 Oct; 263(4 Pt 1):C913-6. PMID: 1415677.
    Citations: 18     Fields:    Translation:AnimalsCells
  113. Sabolic I, Culic O, Lin SH, Brown D. Localization of ecto-ATPase in rat kidney and isolated renal cortical membrane vesicles. Am J Physiol. 1992 Feb; 262(2 Pt 2):F217-28. PMID: 1311523.
    Citations: 9     Fields:    Translation:AnimalsCells
  114. Sabolic I, Shi LB, Brown D, Ausiello DA, Verkman AS. Proteinases inhibit H(+)-ATPase and Na+/H+ exchange but not water transport in apical and endosomal membranes from rat proximal tubule. Biochim Biophys Acta. 1992 Jan 10; 1103(1):137-47. PMID: 1309658.
    Citations: 2     Fields:    Translation:AnimalsCells
  115. Stow JL, Sabolic I, Brown D. Heterogeneous localization of G protein alpha-subunits in rat kidney. Am J Physiol. 1991 Nov; 261(5 Pt 2):F831-40. PMID: 1951714.
    Citations: 13     Fields:    Translation:AnimalsCells
  116. Brown D, Sabolic I, Gluck S. Colchicine-induced redistribution of proton pumps in kidney epithelial cells. Kidney Int Suppl. 1991 Jul; 33:S79-83. PMID: 1653875.
    Citations: 12     Fields:    Translation:AnimalsCells
  117. Sabolic I, Brown D. Na+(Li+)-H+ exchange in rat renal cortical vesicles with endosomal characteristics. Am J Physiol. 1990 May; 258(5 Pt 2):F1245-53. PMID: 1692448.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.