Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Gary B. Ruvkun, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG043184 (RUVKUN, GARY B.) Aug 15, 2012 - Mar 31, 2022
    Inositol signaling in C. elegans Senescence and Diapause
    Role: Principal Investigator
  2. R01GM098647 (RUVKUN, GARY B.) Sep 30, 2011 - Aug 31, 2016
    Modified nucleotide cofactors and the interaction of the RNAome with the proteome
    Role: Principal Investigator
  3. R01DK070147 (RUVKUN, GARY B.) Sep 15, 2004 - Aug 31, 2014
    Genomic analysis of C. elegans fat regulatory pathways
    Role: Principal Investigator
  4. R56AG016636 (RUVKUN, GARY B) Sep 30, 1999 - Aug 31, 2022
    Genetic and Molecular Basis of Longevity
    Role: Principal Investigator
  5. R01AG016636 (RUVKUN, GARY B.) Apr 1, 1999 - Feb 28, 2021
    Genetic and Molecular Basis of Longevity
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ruvkun G, Lehrbach N. Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. Cold Spring Harb Perspect Biol. 2022 Aug 08. PMID: 35940907.
    Citations:    Fields:    
  2. Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G. Author Correction: Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2022 Jun; 24(6):1005-1007. PMID: 35411089.
    Citations:    Fields:    
  3. Ji F, Bonilla G, Krykbaev R, Ruvkun G, Tabach Y, Sadreyev RI. DEPCOD: a tool to detect and visualize co-evolution of protein domains. Nucleic Acids Res. 2022 May 10. PMID: 35536332; PMCID: PMC9252791.
    Citations:    Fields:    
  4. Snoozy J, Breen PC, Ruvkun G, Warnhoff K. moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans. MicroPubl Biol. 2022; 2022. PMID: 35224462; PMCID: PMC8864482.
  5. Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MJ, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM. Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Res. 2021 09 07; 49(15):8836-8865. PMID: 34329465; PMCID: PMC8421154.
    Citations: 7     Fields:    Translation:AnimalsCells
  6. Warnhoff K, Hercher TW, Mendel RR, Ruvkun G. Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans. Genes Dev. 2021 02 01; 35(3-4):212-217. PMID: 33446569; PMCID: PMC7849362.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  7. Bryan NC, Lebreton F, Gilmore M, Ruvkun G, Zuber MT, Carr CE. Genomic and Functional Characterization of Enterococcus faecalis Isolates Recovered From the International Space Station and Their Potential for Pathogenicity. Front Microbiol. 2020; 11:515319. PMID: 33505359.
  8. Mao K, Breen P, Ruvkun G. Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. PLoS Biol. 2020 12; 18(12):e3000996. PMID: 33264285.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Nanopore sequencing at Mars, Europa, and microgravity conditions. NPJ Microgravity. 2020 Sep 07; 6(1):24. PMID: 34489469.
    Citations: 2     
  10. Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Nanopore sequencing at Mars, Europa, and microgravity conditions. NPJ Microgravity. 2020; 6:24. PMID: 32964110; PMCID: PMC7477557.
    Citations: 4     
  11. Wei W, Ruvkun G. Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19970-19981. PMID: 32737159.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Fischer SEJ, Ruvkun G. Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):5987-5996. PMID: 32123111.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Govindan JA, Jayamani E, Ruvkun G. ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21651-21658. PMID: 31591219; PMCID: PMC6815122.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE. Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection. Astrobiology. 2019 09; 19(9):1139-1152. PMID: 31204862.
    Citations: 1     Fields:    Translation:HumansCells
  15. Armakola M, Ruvkun G. Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes. Proc Natl Acad Sci U S A. 2019 06 18; 116(25):12327-12336. PMID: 31164416; PMCID: PMC6589651.
    Citations: 2     Fields:    Translation:AnimalsCells
  16. Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019 05 30; 177(6):1507-1521.e16. PMID: 31031004.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  17. Lehrbach NJ, Breen PC, Ruvkun G. Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression. Cell. 2019 04 18; 177(3):737-750.e15. PMID: 31002798; PMCID: PMC6574124.
    Citations: 36     Fields:    Translation:AnimalsCells
  18. Lehrbach NJ, Ruvkun G. Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 2019 04 11; 8. PMID: 30973820; PMCID: PMC6459674.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  19. Warnhoff K, Ruvkun G. Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nat Chem Biol. 2019 05; 15(5):480-488. PMID: 30911177; PMCID: PMC6470025.
    Citations: 9     Fields:    Translation:Animals
  20. Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metab. 2019 05 07; 29(5):1182-1191.e4. PMID: 30799287; PMCID: PMC6506380.
    Citations: 18     Fields:    Translation:AnimalsCells
  21. Kniazeva M, Ruvkun G. Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3784-3792. PMID: 30808764; PMCID: PMC6397575.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG. DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nat Commun. 2018 10 23; 9(1):4400. PMID: 30353013.
    Citations: 48     Fields:    Translation:AnimalsCells
  23. Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH. Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Genetics. 2018 12; 210(4):1329-1337. PMID: 30287474; PMCID: PMC6283152.
    Citations: 6     Fields:    Translation:AnimalsCells
  24. Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT. Acceleration profiles and processing methods for parabolic flight. NPJ Microgravity. 2018; 4:14. PMID: 30109261; PMCID: PMC6081456.
    Citations: 2     
  25. Ambros V, Ruvkun G. Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018 07; 209(3):651-673. PMID: 29967059.
    Citations: 22     Fields:    Translation:Animals
  26. Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE. Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sci Space Res (Amst). 2018 Aug; 18:80-86. PMID: 30100151.
    Citations: 3     Fields:    Translation:Humans
  27. Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G. The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Genes Dev. 2018 05 01; 32(9-10):670-681. PMID: 29739806; PMCID: PMC6004069.
    Citations: 11     Fields:    Translation:AnimalsCells
  28. Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE. CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. BMC Bioinformatics. 2018 03 27; 19(1):108. PMID: 29587645.
    Citations: 5     Fields:    Translation:Cells
  29. Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE. Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Front Microbiol. 2017; 8:1819. PMID: 29018418; PMCID: PMC5623196.
    Citations: 19     
  30. Mojarro A, Ruvkun G, Zuber MT, Carr CE. Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. 2017 08; 17(8):747-760. PMID: 28704064.
    Citations: 10     Fields:    
  31. Lehrbach NJ, Ruvkun G. Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 2016 08 16; 5. PMID: 27528192.
    Citations: 89     Fields:    Translation:Animals
  32. Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G. A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev. 2016 07 01; 30(13):1515-28. PMID: 27401555; PMCID: PMC4949325.
    Citations: 26     Fields:    Translation:AnimalsCells
  33. Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G. Caenorhabditis elegans responses to bacteria from its natural habitats. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3941-9. PMID: 27317746; PMCID: PMC4941482.
    Citations: 119     Fields:    Translation:Animals
  34. Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F. Planetary Protection and Mars Special Regions--A Suggestion for Updating the Definition. Astrobiology. 2016 Feb; 16(2):119-25. PMID: 26848950.
    Citations: 10     Fields:    
  35. Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G. Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):12456-61. PMID: 26392561; PMCID: PMC4603447.
    Citations: 11     Fields:    Translation:AnimalsCells
  36. Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G. Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2015 Oct; 17(10):1294-303. PMID: 26322678; PMCID: PMC4589496.
    Citations: 11     Fields:    Translation:AnimalsCells
  37. Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA. piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Dev Cell. 2015 Aug 24; 34(4):457-65. PMID: 26279487; PMCID: PMC4550515.
    Citations: 40     Fields:    Translation:AnimalsCells
  38. Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y. PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. 2015 Jul 01; 43(W1):W154-9. PMID: 25958392; PMCID: PMC4489270.
    Citations: 21     Fields:    Translation:HumansAnimals
  39. Kirienko NV, Ausubel FM, Ruvkun G. Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1821-6. PMID: 25624506; PMCID: PMC4330731.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  40. O'Rourke EJ, Ruvkun G. Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2014 Dec 23; 17(1):104. PMID: 25534088.
  41. Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G. Gene pathways that delay Caenorhabditis elegans reproductive senescence. PLoS Genet. 2014 Dec; 10(12):e1004752. PMID: 25474471.
    Citations: 20     Fields:    Translation:AnimalsCells
  42. Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G. Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014 Aug; 21(8):712-20. PMID: 25038802.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  43. Liu Y, Samuel BS, Breen PC, Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014 Apr 17; 508(7496):406-10. PMID: 24695221.
    Citations: 146     Fields:    Translation:AnimalsCells
  44. Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Curr Biol. 2014 Apr 14; 24(8):839-44. PMID: 24684932.
    Citations: 31     Fields:    Translation:AnimalsCells
  45. Govindan JA, Ruvkun G. Pathogens. Virulence. 2014; 5(7):695-6. PMID: 25513769.
    Citations:    Fields:    Translation:HumansAnimals
  46. Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013 Dec 15; 27(24):2678-95. PMID: 24352423.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  47. Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 2013 Dec 05; 155(6):1409-21. PMID: 24269006; PMCID: PMC3956118.
    Citations: 267     Fields:    Translation:AnimalsCells
  48. Soukas AA, Carr CE, Ruvkun G. Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet. 2013 Oct; 9(10):e1003908. PMID: 24204312; PMCID: PMC3812091.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  49. Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G. Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol. 2013 Oct 01; 9:692. PMID: 24084807.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  50. Shi Z, Hayes G, Ruvkun G. Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. PLoS One. 2013; 8(9):e75475. PMID: 24058689.
    Citations: 6     Fields:    Translation:AnimalsCells
  51. Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G. Radiation resistance of sequencing chips for in situ life detection. Astrobiology. 2013 Jun; 13(6):560-9. PMID: 23734755.
    Citations: 2     Fields:    
  52. Shore DE, Ruvkun G. A cytoprotective perspective on longevity regulation. Trends Cell Biol. 2013 Sep; 23(9):409-20. PMID: 23726168.
    Citations: 69     Fields:    Translation:AnimalsCells
  53. Montgomery TA, Ruvkun G. MicroRNAs visit the ER. Cell. 2013 Apr 25; 153(3):511-2. PMID: 23622236.
    Citations: 1     Fields:    
  54. O'Rourke EJ, Ruvkun G. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013 Jun; 15(6):668-76. PMID: 23604316.
    Citations: 149     Fields:    Translation:AnimalsCells
  55. Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013 May; 15(5):491-501. PMID: 23604319.
    Citations: 96     Fields:    Translation:AnimalsCells
  56. Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM. Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe. 2013 Apr 17; 13(4):406-16. PMID: 23601103.
    Citations: 83     Fields:    Translation:AnimalsCells
  57. O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G. ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013 Feb 15; 27(4):429-40. PMID: 23392608.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  58. Shi Z, Montgomery TA, Qi Y, Ruvkun G. High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res. 2013 Mar; 23(3):497-508. PMID: 23363624.
    Citations: 36     Fields:    Translation:Animals
  59. Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G. Radiation resistance of biological reagents for in situ life detection. Astrobiology. 2013 Jan; 13(1):68-78. PMID: 23330963.
    Citations: 7     Fields:    
  60. Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 2013 Jan 31; 493(7434):694-8. PMID: 23364702.
    Citations: 84     Fields:    Translation:AnimalsCells
  61. Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP. Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One. 2012; 7(10):e48282. PMID: 23144747.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  62. Zhang C, Ruvkun G. New insights into siRNA amplification and RNAi. RNA Biol. 2012 Aug; 9(8):1045-9. PMID: 22858672.
    Citations: 15     Fields:    Translation:Animals
  63. Shore DE, Carr CE, Ruvkun G. Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012; 8(7):e1002792. PMID: 22829775.
    Citations: 66     Fields:    Translation:AnimalsCells
  64. Phillips CM, Montgomery TA, Breen PC, Ruvkun G. MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012 Jul 01; 26(13):1433-44. PMID: 22713602.
    Citations: 76     Fields:    Translation:AnimalsCells
  65. Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Curr Biol. 2012 May 22; 22(10):881-90. PMID: 22542102.
    Citations: 29     Fields:    Translation:AnimalsCells
  66. Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE. An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012 Apr 22; 9(7):714-6. PMID: 22522656.
    Citations: 76     Fields:    Translation:Animals
  67. Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet. 2012; 8(4):e1002616. PMID: 22536158.
    Citations: 73     Fields:    Translation:AnimalsCells
  68. Melo JA, Ruvkun G. Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell. 2012 Apr 13; 149(2):452-66. PMID: 22500807.
    Citations: 179     Fields:    Translation:AnimalsCells
  69. Wu X, Shi Z, Cui M, Han M, Ruvkun G. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet. 2012; 8(3):e1002542. PMID: 22412383.
    Citations: 34     Fields:    Translation:AnimalsCells
  70. Shi Z, Ruvkun G. The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4568-73. PMID: 22396595.
    Citations: 19     Fields:    Translation:AnimalsCells
  71. Kimura KD, Riddle DL, Ruvkun G. The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status. Cold Spring Harb Symp Quant Biol. 2011; 76:113-20. PMID: 22123849.
    Citations: 21     Fields:    Translation:AnimalsCells
  72. Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011 Nov; 7(11):e1002369. PMID: 22102828.
    Citations: 42     Fields:    Translation:AnimalsCells
  73. Russel S, Frand AR, Ruvkun G. Regulation of the C. elegans molt by pqn-47. Dev Biol. 2011 Dec 15; 360(2):297-309. PMID: 21989027.
    Citations: 19     Fields:    Translation:Animals
  74. Hayes GD, Riedel CG, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011 Oct 01; 25(19):2079-92. PMID: 21979920.
    Citations: 9     Fields:    Translation:AnimalsCells
  75. Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1201-8. PMID: 21245313.
    Citations: 75     Fields:    Translation:AnimalsCells
  76. Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS. RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods. 2011 Feb; 8(2):135-8. PMID: 21240281.
    Citations: 71     Fields:    Translation:Animals
  77. Wu X, Ruvkun G. Cancer. Germ cell genes and cancer. Science. 2010 Dec 24; 330(6012):1761-2. PMID: 21205660.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  78. Meli VS, Osuna B, Ruvkun G, Frand AR. MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell. 2010 May 15; 21(10):1648-61. PMID: 20335506.
    Citations: 22     Fields:    Translation:AnimalsCells
  79. Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009 Dec 14; 4(12):e8210. PMID: 20011587.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  80. O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009 Nov; 10(5):430-5. PMID: 19883620.
    Citations: 213     Fields:    Translation:AnimalsCells
  81. Curran SP, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009 Jun 25; 459(7250):1079-84. PMID: 19506556.
    Citations: 63     Fields:    Translation:AnimalsCells
  82. Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009 Feb 15; 23(4):496-511. PMID: 19240135; PMCID: PMC2648650.
    Citations: 212     Fields:    Translation:AnimalsCells
  83. Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY. Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1875-9. PMID: 19174521.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  84. Wang MC, O'Rourke EJ, Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science. 2008 Nov 07; 322(5903):957-60. PMID: 18988854.
    Citations: 193     Fields:    Translation:AnimalsCells
  85. Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G. The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph. 2008 Dec; 38(6):517-33. PMID: 18853276.
    Citations: 23     Fields:    Translation:Cells
  86. Ruvkun G. The perfect storm of tiny RNAs. Nat Med. 2008 Oct; 14(10):1041-5. PMID: 18841145.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  87. Fischer SE, Butler MD, Pan Q, Ruvkun G. Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 2008 Sep 25; 455(7212):491-6. PMID: 18784652.
    Citations: 54     Fields:    Translation:AnimalsCells
  88. Ruvkun G. Tiny RNA: Where do we come from? What are we? Where are we going? Trends Plant Sci. 2008 Jul; 13(7):313-6. PMID: 18562240.
    Citations: 2     Fields:    Translation:AnimalsCells
  89. Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008 May 30; 133(5):903-15. PMID: 18510933.
    Citations: 104     Fields:    Translation:AnimalsCells
  90. Patel DS, Fang LL, Svy DK, Ruvkun G, Li W. Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 2008 Jul; 135(13):2239-49. PMID: 18495818.
    Citations: 25     Fields:    Translation:AnimalsCells
  91. Gabel HW, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008 May; 15(5):531-3. PMID: 18438419.
    Citations: 32     Fields:    Translation:AnimalsCells
  92. Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 2008 Jan-Feb; 10(1):106-13. PMID: 18184361; PMCID: PMC2637451.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  93. Isenbarger TA, Finney M, Ríos-Velázquez C, Handelsman J, Ruvkun G. Miniprimer PCR, a new lens for viewing the microbial world. Appl Environ Microbiol. 2008 Feb; 74(3):840-9. PMID: 18083877.
    Citations: 27     Fields:    Translation:CellsPHPublic Health
  94. Parry DH, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007 Dec 04; 17(23):2013-22. PMID: 18023351.
    Citations: 54     Fields:    Translation:Animals
  95. Samuelson AV, Carr CE, Ruvkun G. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007 Nov 15; 21(22):2976-94. PMID: 18006689.
    Citations: 107     Fields:    Translation:AnimalsCells
  96. Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY. Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics. 2007 Oct; 177(2):835-45. PMID: 17720915.
    Citations: 17     Fields:    Translation:AnimalsCells
  97. Curran SP, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007 Apr 06; 3(4):e56. PMID: 17411345; PMCID: PMC1847696.
    Citations: 241     Fields:    Translation:AnimalsCells
  98. Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol. 2007; 72:489-97. PMID: 18419309.
    Citations: 14     Fields:    Translation:Animals
  99. Hayes GD, Frand AR, Ruvkun G. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 2006 Dec; 133(23):4631-41. PMID: 17065234.
    Citations: 64     Fields:    Translation:AnimalsCells
  100. Ruvinsky I, Ohler U, Burge CB, Ruvkun G. Detection of broadly expressed neuronal genes in C. elegans. Dev Biol. 2007 Feb 15; 302(2):617-26. PMID: 17046742.
    Citations: 22     Fields:    Translation:AnimalsCells
  101. Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006 Jul; 2(7):e99. PMID: 16839187; PMCID: PMC1487177.
    Citations: 31     Fields:    Translation:AnimalsCells
  102. Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci. 2006 May; 9(5):599-601. PMID: 16604067.
    Citations: 14     Fields:    Translation:Animals
  103. Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nat Genet. 2006 Mar; 38(3):363-8. PMID: 16462744.
    Citations: 99     Fields:    Translation:AnimalsCells
  104. Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006 Jan 27; 124(2):343-54. PMID: 16439208.
    Citations: 212     Fields:    Translation:AnimalsCells
  105. Ruvkun G. Clarifications on miRNA and cancer. Science. 2006 Jan 06; 311(5757):36-7. PMID: 16400132.
    Citations: 50     Fields:    Translation:HumansAnimals
  106. Hayes GD, Ruvkun G. Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harb Symp Quant Biol. 2006; 71:21-7. PMID: 17381276.
    Citations: 16     Fields:    Translation:AnimalsCells
  107. Frand AR, Russel S, Ruvkun G. Functional genomic analysis of C. elegans molting. PLoS Biol. 2005 Oct; 3(10):e312. PMID: 16122351; PMCID: PMC1233573.
    Citations: 139     Fields:    Translation:AnimalsCells
  108. Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005 Jul 28; 436(7050):593-7. PMID: 16049496.
    Citations: 141     Fields:    Translation:AnimalsCells
  109. Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM. Systematic analysis of genes required for synapse structure and function. Nature. 2005 Jul 28; 436(7050):510-7. PMID: 16049479.
    Citations: 190     Fields:    Translation:AnimalsCells
  110. Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005 Jul 01; 19(13):1544-55. PMID: 15998808; PMCID: PMC1172061.
    Citations: 228     Fields:    Translation:Animals
  111. Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P. Analysis of xbx genes in C. elegans. Development. 2005 Apr; 132(8):1923-34. PMID: 15790967.
    Citations: 96     Fields:    Translation:AnimalsCells
  112. Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science. 2005 May 20; 308(5725):1164-7. PMID: 15790806.
    Citations: 149     Fields:    Translation:AnimalsCells
  113. Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004 Oct; 36(10):1079-83. PMID: 15361871.
    Citations: 168     Fields:    Translation:AnimalsCells
  114. Mak HY, Ruvkun G. Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development. 2004 Apr; 131(8):1777-86. PMID: 15084462.
    Citations: 46     Fields:    Translation:AnimalsCells
  115. Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell. 2004 Feb 27; 13(4):469-82. PMID: 14992718.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  116. Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004 Feb 12; 427(6975):645-9. PMID: 14961122.
    Citations: 256     Fields:    Translation:HumansAnimalsCells
  117. Ruvkun G, Wightman B, Ha I. The 20 years it took to recognize the importance of tiny RNAs. Cell. 2004 Jan 23; 116(2 Suppl):S93-6, 2 p following S96. PMID: 15055593.
    Citations: 21     Fields:    Translation:Animals
  118. Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2004; 69:429-31. PMID: 16117677.
    Citations: 17     Fields:    Translation:AnimalsCells
  119. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):360-5. PMID: 14691248; PMCID: PMC314190.
    Citations: 228     Fields:    Translation:AnimalsCells
  120. Komaroff AL, Ruvkun G. Unraveling the secrets of the cell. Newsweek. 2003 Dec 08; 142(23):96. PMID: 14712576.
    Citations:    Fields:    Translation:HumansAnimals
  121. Ruvinsky I, Ruvkun G. Functional tests of enhancer conservation between distantly related species. Development. 2003 Nov; 130(21):5133-42. PMID: 12944426.
    Citations: 39     Fields:    Translation:AnimalsCells
  122. Aspöck G, Ruvkun G, Bürglin TR. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development. 2003 Aug; 130(15):3369-78. PMID: 12810585.
    Citations: 17     Fields:    Translation:AnimalsCells
  123. Sze JY, Ruvkun G. Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9560-5. PMID: 12883006; PMCID: PMC170957.
    Citations: 13     Fields:    Translation:AnimalsCells
  124. Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003 Jul 01; 259(1):1-8. PMID: 12812783.
    Citations: 42     Fields:    Translation:AnimalsCells
  125. Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J. Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evol Dev. 2003 Jul-Aug; 5(4):372-8. PMID: 12823453.
    Citations: 31     Fields:    Translation:Animals
  126. Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003 Jun 20; 300(5627):1921. PMID: 12817143.
    Citations: 270     Fields:    Translation:AnimalsCells
  127. Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Mol Cell. 2003 May; 11(5):1253-63. PMID: 12769849.
    Citations: 112     Fields:    Translation:AnimalsCells
  128. Lee SS, Kennedy S, Tolonen AC, Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science. 2003 Apr 25; 300(5619):644-7. PMID: 12690206.
    Citations: 255     Fields:    Translation:AnimalsCells
  129. Li W, Kennedy SG, Ruvkun G. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 2003 Apr 01; 17(7):844-58. PMID: 12654727; PMCID: PMC196030.
    Citations: 159     Fields:    Translation:AnimalsCells
  130. Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T. A uniform system for microRNA annotation. RNA. 2003 Mar; 9(3):277-9. PMID: 12592000.
    Citations: 733     Fields:    
  131. Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003 Jan 16; 421(6920):268-72. PMID: 12529643.
    Citations: 365     Fields:    Translation:HumansAnimalsCells
  132. Ruvkun GB. The tiny RNA world. Harvey Lect. 2003-2004; 99:1-21. PMID: 15984549.
    Citations: 7     Fields:    Translation:AnimalsCells
  133. Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet. 2003 Jan; 33(1):40-8. PMID: 12447374.
    Citations: 358     Fields:    Translation:AnimalsCells
  134. Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002 Dec 20; 277(51):49591-7. PMID: 12393910.
    Citations: 49     Fields:    Translation:AnimalsCells
  135. Sze JY, Zhang S, Li J, Ruvkun G. The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development. 2002 Aug; 129(16):3901-11. PMID: 12135927.
    Citations: 45     Fields:    Translation:AnimalsCells
  136. Lee SS, Ruvkun G. Longevity: don't hold your breath. Nature. 2002 Jul 18; 418(6895):287-8. PMID: 12124610.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  137. Pasquinelli AE, Ruvkun G. Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002; 18:495-513. PMID: 12142272.
    Citations: 118     Fields:    Translation:Animals
  138. Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001 Dec 11; 11(24):1950-7. PMID: 11747821.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  139. Ruvkun G. Molecular biology. Glimpses of a tiny RNA world. Science. 2001 Oct 26; 294(5543):797-9. PMID: 11679654.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  140. Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13; 106(1):23-34. PMID: 11461699.
    Citations: 739     Fields:    Translation:Animals
  141. Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001 Mar 15; 15(6):672-86. PMID: 11274053; PMCID: PMC312654.
    Citations: 262     Fields:    Translation:HumansAnimalsCells
  142. Bürglin TR, Ruvkun G. Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development. 2001 Mar; 128(5):779-90. PMID: 11171402.
    Citations: 23     Fields:    Translation:AnimalsCells
  143. Reinhart BJ, Ruvkun G. Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001 Jan; 157(1):199-209. PMID: 11139502.
    Citations: 18     Fields:    Translation:AnimalsCells
  144. Finch CE, Ruvkun G. The genetics of aging. Annu Rev Genomics Hum Genet. 2001; 2:435-62. PMID: 11701657.
    Citations: 110     Fields:    Translation:HumansAnimals
  145. Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem. 2001 Apr 20; 276(16):13402-10. PMID: 11124266.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  146. Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000 Nov 02; 408(6808):86-9. PMID: 11081512.
    Citations: 815     Fields:    Translation:HumansAnimalsCells
  147. Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR. Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Dev Genes Evol. 2000 Nov; 210(11):564-9. PMID: 11180807.
    Citations:    Fields:    Translation:AnimalsCells
  148. Wolkow CA, Kimura KD, Lee MS, Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science. 2000 Oct 06; 290(5489):147-50. PMID: 11021802.
    Citations: 234     Fields:    Translation:AnimalsCells
  149. Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10412-7. PMID: 10973497; PMCID: PMC27038.
    Citations: 53     Fields:    Translation:HumansCells
  150. Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000 Apr; 5(4):659-69. PMID: 10882102.
    Citations: 279     Fields:    Translation:AnimalsCells
  151. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24; 403(6772):901-6. PMID: 10706289.
    Citations: 1782     Fields:    Translation:AnimalsCells
  152. Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 2000 Feb 03; 403(6769):560-4. PMID: 10676966.
    Citations: 282     Fields:    Translation:AnimalsCells
  153. Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci U S A. 2000 Jan 04; 97(1):460-5. PMID: 10618440; PMCID: PMC26685.
    Citations: 41     Fields:    Translation:AnimalsCells
  154. Davidson EH, Ruvkun G. Themes from a NASA workshop on gene regulatory processes in development and evolution. J Exp Zool. 1999 Aug 15; 285(2):104-15. PMID: 10440721.
    Citations: 1     Fields:    Translation:Animals
  155. Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999 Jul 15; 13(14):1794-806. PMID: 10421632; PMCID: PMC316880.
    Citations: 65     Fields:    Translation:AnimalsCells
  156. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999 Jun 01; 13(11):1438-52. PMID: 10364160; PMCID: PMC316759.
    Citations: 155     Fields:    Translation:HumansAnimalsCells
  157. Hobert O, Ruvkun G. Pax genes in Caenorhabditis elegans: a new twist. Trends Genet. 1999 Jun; 15(6):214-6. PMID: 10354580.
    Citations: 9     Fields:    Translation:AnimalsCells
  158. Hobert O, Tessmar K, Ruvkun G. The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development. 1999 Apr; 126(7):1547-62. PMID: 10068647.
    Citations: 37     Fields:    Translation:AnimalsCells
  159. Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999 Jan 11; 144(1):45-57. PMID: 9885243; PMCID: PMC2148118.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  160. Ruvkun G, Hobert O. The taxonomy of developmental control in Caenorhabditis elegans. Science. 1998 Dec 11; 282(5396):2033-41. PMID: 9851920.
    Citations: 83     Fields:    Translation:AnimalsCells
  161. Hobert O, Ruvkun G. A common theme for LIM homeobox gene function across phylogeny? Biol Bull. 1998 Dec; 195(3):377-80. PMID: 9924780.
    Citations: 9     Fields:    Translation:Animals
  162. Slack FJ, Ruvkun G. A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci. 1998 Dec; 23(12):474-5. PMID: 9868369.
    Citations: 68     Fields:    Translation:Cells
  163. Ogg S, Ruvkun G. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell. 1998 Dec; 2(6):887-93. PMID: 9885576.
    Citations: 165     Fields:    Translation:AnimalsCells
  164. Slack F, Ruvkun G. Heterochronic genes in development and evolution. Biol Bull. 1998 Dec; 195(3):375-6. PMID: 9924779.
    Citations: 3     Fields:    Translation:Animals
  165. Guarente L, Ruvkun G, Amasino R. Aging, life span, and senescence. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11034-6. PMID: 9736682; PMCID: PMC33892.
    Citations: 8     Fields:    Translation:Animals
  166. Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998 Aug 15; 12(16):2488-98. PMID: 9716402; PMCID: PMC317081.
    Citations: 249     Fields:    Translation:AnimalsCells
  167. Hobert O, D'Alberti T, Liu Y, Ruvkun G. Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J Neurosci. 1998 Mar 15; 18(6):2084-96. PMID: 9482795; PMCID: PMC6792926.
    Citations: 36     Fields:    Translation:AnimalsCells
  168. Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 1998 Feb; 148(2):703-17. PMID: 9504918.
    Citations: 117     Fields:    Translation:AnimalsCells
  169. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997 Oct 30; 389(6654):994-9. PMID: 9353126.
    Citations: 775     Fields:    Translation:HumansAnimalsCells
  170. Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 1997 Oct 15; 11(20):2679-90. PMID: 9334330; PMCID: PMC316611.
    Citations: 84     Fields:    Translation:AnimalsCells
  171. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997 Aug 15; 277(5328):942-6. PMID: 9252323.
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  172. Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron. 1997 Aug; 19(2):345-57. PMID: 9292724.
    Citations: 105     Fields:    Translation:AnimalsCells
  173. Sluder AE, Lindblom T, Ruvkun G. The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Dev Biol. 1997 Apr 15; 184(2):303-19. PMID: 9133437.
    Citations: 5     Fields:    Translation:AnimalsCells
  174. Sze JY, Liu Y, Ruvkun G. VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development. 1997 Mar; 124(6):1159-68. PMID: 9102303.
    Citations: 5     Fields:    Translation:AnimalsCells
  175. Slack F, Ruvkun G. Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1997; 31:611-34. PMID: 9442909.
    Citations: 31     Fields:    Translation:HumansAnimals
  176. Ha I, Wightman B, Ruvkun G. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev. 1996 Dec 01; 10(23):3041-50. PMID: 8957004.
    Citations: 88     Fields:    Translation:AnimalsCells
  177. Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996 Aug 08; 382(6591):536-9. PMID: 8700226.
    Citations: 294     Fields:    Translation:AnimalsCells
  178. Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem. 1996 Jul; 67(1):46-57. PMID: 8667025.
    Citations: 12     Fields:    Translation:AnimalsCells
  179. Baumeister R, Liu Y, Ruvkun G. Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev. 1996 Jun 01; 10(11):1395-410. PMID: 8647436.
    Citations: 36