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Lynn Bry, Ph.D., M.D.

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Overview
Research: Mucosal Immunology/Infectious Disease

My laboratory studies the following aspects of host defense against microbial pathogens (1) host reponses against attaching and effacing pathogens such as Citrobacter rodentium and the enteropathogenic E. coli (EPEC), (2) the molecular basis of immunoprotection from colonization with commensals and (3) recruitment of adaptive memory responses against non-invasive enteric pathogens to fight primary infection with phylogenetically related invasive species.

We have defined the effector functions and locations at which protective T cell and B cell responses develop against the murine attaching and effacing pathogen Citrobacter rodentium. This EPEC-like organism produces a primary infection of the apical surface of the gut epithelium. Surprisingly, systemic and CD4+ T cell dependent IgG, and not mucosal IgA, proved the critical adaptive response needed to successfully control mucosal infection. Pathogen-specific IgG acts systemically and in the gut lumen to effect erradication of pathogens from the host. We have subsequently shown that interactions with complement are important for this erradication and for the development of specific IgG.

We have further developed this model to elucidate how the commensal flora primes adaptive responses recruited early in infection with C. rodentium. By forming the HDDC Gnotobiotic Mouse Core, we expect to be able to define how members of the commensal flora provide protection against phylogenetically related or unrelated organisms, through mechanisms including colonization resistance as well as cognate and non-cognate effects upon the immune system.

Research: Crimson Application - IT infrastructure to support high-through sample collection and downstream applications for a research enterprise.

Crimson prospectively matches discarded samples from clinical laboratories per investigator-defined criteria. This feature effectively harnesses the thousands of samples and associated data generated daily in clinical laboratories for productive use in IRB-approved studies. Additional functions of Crimson include management of sample inventories, user workgroups, and auditing capabilities to insure compliance with HIPAA and local IRBs. As of May 2007, Crimson has been integrated with the Research Patient Data Registry (RPDR), a clinical data repository that houses electronic information generated at BWH and MGH. This integration allows an investigator to define a cohort of patients on the RPDR and forward it to Crimson for collection of discarded samples.

Crimson went live on 2/1/2007 and has since handled >15,000 samples in its first year of operations, including >10,000 clinical trials samples and >5,000 discarded pathology samples collected for use by IRB-approved studies. The application was developed by myself and Neil Herring in the Pathology IT Division at BWH with software development support for Daedalus Software Inc. in Cambridge MA. Crimson remains a unique an innovative system, one that is being adopted by i2b2 (Informatics for Integrating Biology to the Bedside), an NIH Roadmap initiative.


Teaching:

I teach in the medical school courses IN704.0: "Immunology, Microbiology and Infectious Disease," HST-040: "Mechanisms of Microbial Pathogenesis" and the clerkship PA511M.J: "Clinical Laboratory Medicine." I am also course director for the clinical microbiology rotation at Brigham & Women's Hospital through which pathology residents and infectious disease fellows rotate, and organize the weekly plate rounds between the Clinical Laboratories and Division of Infectious Disease at Brigham & Women’s Hospital.

I am also a lecturer and mentor for the Project Success Program at Harvard Medical School.

Clinical:

As Associate Medical Director in the Clinical Microbiology Laboratory at Brigham and Women's Hospital, my duties include oversight of routine microbiological testing, evaluation and implementation of new modalities for diagnosing infectious diseases and determining antimicrobial resistance.

Since 2006 I have successfully worked to bring in additional high-throughput platforms for the molecular diagnosis of infectious agents, including HIV, HCV, gonorrhea and Chlamydia. I have also worked with clinicians in the renal division to implement decision/support trees based on key data from testing for BK virus in renal transplant patients, and with individuals in the pulmonary division to assist with microbiological assessment of cystic fibrosis patients seen at BWH.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI153605 (BRY, LYNN) Feb 1, 2021 - Jan 31, 2026
    NIH
    Commensal control of C. difficile virulence
    Role: Principal Investigator
  2. R01HD061916 (MANTIS, NICHOLAS J) Sep 15, 2009 - Jul 31, 2016
    NIH
    Epithelial Glycoconjugates as Barriers against Enteric Infections
    Role: Principal Investigator
  3. R01LM010100 (BRY, LYNN) Sep 1, 2009 - Aug 31, 2012
    NIH
    Crimson - i2b2 integration for high-throughput, scalable sample collection
    Role: Principal Investigator
  4. R21AI059628 (BRY, LYNN) Apr 1, 2004 - Mar 31, 2008
    NIH
    Protective role of cross-reactive anti-enteric antibody
    Role: Principal Investigator
  5. K08AI051734 (BRY, LYNN) Aug 1, 2003 - Jul 31, 2008
    NIH
    Role of T cells in self-limited mucosal infections
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Worley J, Delaney ML, Cummins CK, DuBois A, Klompas M, Bry L. Genomic Determination of Relative Risks for Clostridioides difficile Infection From Asymptomatic Carriage in Intensive Care Unit Patients. Clin Infect Dis. 2021 Oct 05; 73(7):e1727-e1736. PMID: 32676661.
    Citations: 1     Fields:    
  2. Smith-Page K, Kugadas A, Lin T, Delaney M, Bry L, Gadjeva M. Conjunctival Commensal Isolation and Identification in Mice. J Vis Exp. 2021 05 01; (171). PMID: 33999020.
    Citations:    Fields:    
  3. Neto CC, Mortzfeld BM, Turbitt JR, Bhattarai SK, Yeliseyev V, DiBenedetto N, Bry L, Bucci V. Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model. Microb Cell. 2021 Apr 29; 8(6):131-142. PMID: 34055966.
    Citations: 1     
  4. Worley JN, Javkar K, Hoffmann M, Hysell K, Garcia-Williams A, Tagg K, Kanjilal S, Strain E, Pop M, Allard M, Francois Watkins L, Bry L. Genomic Drivers of Multidrug-Resistant Shigella Affecting Vulnerable Patient Populations in the United States and Abroad. mBio. 2021 01 26; 12(1). PMID: 33500335.
    Citations: 1     Fields:    Translation:HumansCells
  5. Mansfield MJ, Tremblay BJ, Zeng J, Wei X, Hodgins H, Worley J, Bry L, Dong M, Doxey AC. Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B. PLoS Pathog. 2020 12; 16(12):e1009181. PMID: 33370413.
    Citations: 1     Fields:    Translation:HumansCells
  6. Turner JA, Stephen-Victor E, Wang S, Rivas MN, Abdel-Gadir A, Harb H, Cui Y, Fanny M, Charbonnier LM, Hung Fong JJ, Benamar M, Wang L, Burton OT, Bansal K, Bry L, Zhu C, Li QZ, Clement RL, Oettgen HC, Crestani E, Rachid R, Sage PT, Chatila TA. Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 Dec 15; 53(6):1331-1332. PMID: 33326768.
    Citations: 2     Fields:    
  7. Turner JA, Stephen-Victor E, Wang S, Rivas MN, Abdel-Gadir A, Harb H, Cui Y, Fanny M, Charbonnier LM, Fong JJH, Benamar M, Wang L, Burton OT, Bansal K, Bry L, Zhu C, Li QZ, Clement RL, Oettgen HC, Crestani E, Rachid R, Sage PT, Chatila TA. Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 12 15; 53(6):1202-1214.e6. PMID: 33086036.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  8. Osgood RS, Tashiro H, Kasahara DI, Yeliseyev V, Bry L, Shore SA. Gut microbiota from androgen-altered donors alter pulmonary responses to ozone in female mice. Physiol Rep. 2020 10; 8(19):e14584. PMID: 33052618.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Ennamorati M, Vasudevan C, Clerkin K, Halvorsen S, Verma S, Ibrahim S, Prosper S, Porter C, Yeliseyev V, Kim M, Gardecki J, Sassi S, Tearney G, Cherayil BJ, Bry L, Seed B, Jain N. Intestinal microbes influence development of thymic lymphocytes in early life. Proc Natl Acad Sci U S A. 2020 02 04; 117(5):2570-2578. PMID: 31964813.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Tashiro H, Cho Y, Kasahara DI, Brand JD, Bry L, Yeliseyev V, Abu-Ali G, Huttenhower C, Shore SA. Microbiota Contribute to Obesity-related Increases in the Pulmonary Response to Ozone. Am J Respir Cell Mol Biol. 2019 12; 61(6):702-712. PMID: 31144984.
    Citations: 10     Fields:    Translation:AnimalsCells
  11. Allegretti JR, Marcus J, Storm M, Sitko J, Kennedy K, Gerber GK, Bry L. Clinical Predictors of Recurrence After Primary Clostridioides difficile Infection: A Prospective Cohort Study. Dig Dis Sci. 2020 06; 65(6):1761-1766. PMID: 31667694.
    Citations:    Fields:    Translation:HumansCells
  12. Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S, Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA. Author Correction: Microbiota therapy acts via a regulatory T cell MyD88/ROR?t pathway to suppress food allergy. Nat Med. 2019 Sep; 25(9):1458. PMID: 31420602.
    Citations: 2     Fields:    
  13. Ziesack M, Gibson T, Oliver JKW, Shumaker AM, Hsu BB, Riglar DT, Giessen TW, DiBenedetto NV, Bry L, Way JC, Silver PA, Gerber GK. Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial Consortium. mSystems. 2019 Aug 13; 4(4). PMID: 31409662.
    Citations: 11     
  14. Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S, Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA. Microbiota therapy acts via a regulatory T cell MyD88/ROR?t pathway to suppress food allergy. Nat Med. 2019 07; 25(7):1164-1174. PMID: 31235962.
    Citations: 53     Fields:    Translation:AnimalsCells
  15. Hsu BB, Gibson TE, Yeliseyev V, Liu Q, Lyon L, Bry L, Silver PA, Gerber GK. Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model. . 2019 Jun 12; 25(6):803-814.e5. PMID: 31175044.
    Citations: 76     Translation:AnimalsCells
  16. Pecora N, Zhao X, Nudel K, Hoffmann M, Li N, Onderdonk AB, Yokoe D, Brown E, Allard M, Bry L. Diverse Vectors and Mechanisms Spread New Delhi Metallo-ß-Lactamases among Carbapenem-Resistant Enterobacteriaceae in the Greater Boston Area. Antimicrob Agents Chemother. 2019 02; 63(2). PMID: 30530605.
    Citations: 5     Fields:    Translation:HumansCells
  17. Crothers J, Bry L. Gutting TMA to Save the Heart. . 2018 10 10; 24(4):470-471. PMID: 30308152.
    Citations: 1     Translation:HumansAnimals
  18. Pirrone M, Imber DA, Marrazzo F, Pinciroli R, Zhang C, Bry L, Delaney ML, Dubois AM, Thomas JG, Nistico L, Melton-Kreft R, Bittner EA, Kacmarek RM, Berra L. Silver-Coated Endotracheal Tubes Cleaned With a Mechanism for Secretion Removal. Respir Care. 2019 01; 64(1):1-9. PMID: 30181363.
    Citations:    Fields:    Translation:HumansPHPublic Health
  19. Kim S, Kerns SJ, Ziesack M, Bry L, Gerber GK, Way JC, Silver PA. Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut. ACS Synth Biol. 2018 09 21; 7(9):2270-2281. PMID: 30125499.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Yao L, Seaton SC, Ndousse-Fetter S, Adhikari AA, DiBenedetto N, Mina AI, Banks AS, Bry L, Devlin AS. A selective gut bacterial bile salt hydrolase alters host metabolism. Elife. 2018 07 17; 7. PMID: 30014852.
    Citations: 53     Fields:    Translation:AnimalsCells
  21. Lavin R, DiBenedetto N, Yeliseyev V, Delaney M, Bry L. Gnotobiotic and Conventional Mouse Systems to Support Microbiota Based Studies. Curr Protoc Immunol. 2018 04; 121(1):e48. PMID: 30008984.
    Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
  22. Fujisaka S, Avila-Pacheco J, Soto M, Kostic A, Dreyfuss JM, Pan H, Ussar S, Altindis E, Li N, Bry L, Clish CB, Kahn CR. Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites. Cell Rep. 2018 03 13; 22(11):3072-3086. PMID: 29539432.
    Citations: 48     Fields:    Translation:HumansAnimals
  23. Basu SS, Delaney ML, Li N, Onderdonk AB, Bry L. Acetobacter indonesiensis Pneumonia after Lung Transplantation. Emerg Infect Dis. 2018 03; 24(3):598-599. PMID: 29460757.
    Citations:    Fields:    Translation:HumansCells
  24. Nudel K, Zhao X, Basu S, Dong X, Hoffmann M, Feldgarden M, Allard M, Klompas M, Bry L. Genomics of Corynebacterium striatum, an emerging multidrug-resistant pathogen of immunocompromised patients. Clin Microbiol Infect. 2018 Sep; 24(9):1016.e7-1016.e13. PMID: 29326010.
    Citations: 7     Fields:    Translation:HumansCells
  25. Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 07 05; 6. PMID: 28678006.
    Citations: 12     Fields:    Translation:AnimalsCells
  26. Ussar S, Haering MF, Fujisaka S, Lutter D, Lee KY, Li N, Gerber GK, Bry L, Kahn CR. Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes. 2017 04; 66(4):886-896. PMID: 28096258.
    Citations: 7     Fields:    Translation:Animals
  27. Fujisaka S, Ussar S, Clish C, Devkota S, Dreyfuss JM, Sakaguchi M, Soto M, Konishi M, Softic S, Altindis E, Li N, Gerber G, Bry L, Kahn CR. Antibiotic effects on gut microbiota and metabolism are host dependent. J Clin Invest. 2016 12 01; 126(12):4430-4443. PMID: 27775551.
    Citations: 42     Fields:    Translation:AnimalsCells
  28. Pallin DJ, Bry L, Dwyer RC, Lipworth AD, Leung DY, Camargo CA, Kupper TS, Filbin MR, Murphy GF. Toward an Objective Diagnostic Test for Bacterial Cellulitis. PLoS One. 2016; 11(9):e0162947. PMID: 27656884.
    Citations: 6     Fields:    
  29. Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L. Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study. Respir Care. 2016 Nov; 61(11):1431-1439. PMID: 27460104.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  30. Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 06 28; 7:12015. PMID: 27352007.
    Citations: 296     Fields:    Translation:HumansCells
  31. Boutin NT, Mathieu K, Hoffnagle AG, Allen NL, Castro VM, Morash M, O'Rourke PP, Hohmann EL, Herring N, Bry L, Slaugenhaupt SA, Karlson EW, Weiss ST, Smoller JW. Implementation of Electronic Consent at a Biobank: An Opportunity for Precision Medicine Research. J Pers Med. 2016 Jun 09; 6(2). PMID: 27294961.
    Citations: 17     
  32. Bucci V, Tzen B, Li N, Simmons M, Tanoue T, Bogart E, Deng L, Yeliseyev V, Delaney ML, Liu Q, Olle B, Stein RR, Honda K, Bry L, Gerber GK. MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses. Genome Biol. 2016 06 03; 17(1):121. PMID: 27259475.
    Citations: 55     Fields:    Translation:AnimalsCells
  33. Allegretti JR, Kearney S, Li N, Bogart E, Bullock K, Gerber GK, Bry L, Clish CB, Alm E, Korzenik JR. Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles. Aliment Pharmacol Ther. 2016 06; 43(11):1142-53. PMID: 27086647.
    Citations: 46     Fields:    Translation:HumansCells
  34. Redhu N, Shouval D, Bakthavatchalu V, Wang C, Conaway E, Goettel J, Mack M, Bleich A, Bry L, Fox J, Snapper S, Horwitz B. O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S2-3. PMID: 26849723.
    Citations:    
  35. Liu S, da Cunha AP, Rezende RM, Cialic R, Wei Z, Bry L, Comstock LE, Gandhi R, Weiner HL. The Host Shapes the Gut Microbiota via Fecal MicroRNA. . 2016 Jan 13; 19(1):32-43. PMID: 26764595.
    Citations: 194     Translation:HumansAnimalsCells
  36. Yu DH, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, Schady D, Roshan TN, Chen MH, Laritsky E, Ge Z, Wang H, Chen R, Westwater C, Bry L, Waterland RA, Moriarty C, Hwang C, Swennes AG, Moore SR, Shen L. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015 Sep 30; 16:211. PMID: 26420038.
    Citations: 46     Fields:    Translation:AnimalsCells
  37. Ussar S, Griffin NW, Bezy O, Fujisaka S, Vienberg S, Softic S, Deng L, Bry L, Gordon JI, Kahn CR. Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome. Cell Metab. 2015 Sep 01; 22(3):516-530. PMID: 26299453.
    Citations: 155     Fields:    Translation:Animals
  38. Pecora ND, Li N, Allard M, Li C, Albano E, Delaney M, Dubois A, Onderdonk AB, Bry L. Genomically Informed Surveillance for Carbapenem-Resistant Enterobacteriaceae in a Health Care System. mBio. 2015 Jul 28; 6(4):e01030. PMID: 26220969.
    Citations: 40     Fields:    Translation:HumansCells
  39. Wang S, Charbonnier LM, Noval Rivas M, Georgiev P, Li N, Gerber G, Bry L, Chatila TA. MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism. Immunity. 2015 Aug 18; 43(2):289-303. PMID: 26231118.
    Citations: 51     Fields:    Translation:AnimalsCells
  40. Louis DN, Feldman M, Carter AB, Dighe AS, Pfeifer JD, Bry L, Almeida JS, Saltz J, Braun J, Tomaszewski JE, Gilbertson JR, Sinard JH, Gerber GK, Galli SJ, Golden JA, Becich MJ. Computational Pathology: A Path Ahead. Arch Pathol Lab Med. 2016 Jan; 140(1):41-50. PMID: 26098131.
    Citations: 21     Fields:    Translation:Humans
  41. Yaung SJ, Deng L, Li N, Braff JL, Church GM, Bry L, Wang HH, Gerber GK. Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics. Mol Syst Biol. 2015 Jan; 11(1):788. PMID: 25762151; PMCID: PMC4380924.
    Citations:    
  42. Yaung SJ, Deng L, Li N, Braff JL, Church GM, Bry L, Wang HH, Gerber GK. Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics. Mol Syst Biol. 2015 Mar; 11(3):788. PMID: 26148351.
    Citations: 7     Fields:    Translation:AnimalsCells
  43. Robb JA, Bry L, Sluss PM, Wagar EA, Kennedy MF. A Call to Standardize Preanalytic Data Elements for Biospecimens, Part II. Arch Pathol Lab Med. 2015 Sep; 139(9):1125-8. PMID: 25594725.
    Citations: 4     Fields:    Translation:Humans
  44. Mietto C, Pinciroli R, Piriyapatsom A, Thomas JG, Bry L, Delaney ML, Du Bois A, Truelove J, Ackman JB, Wojtkiewicz GR, Nahrendorf M, Kacmarek RM, Berra L. Tracheal tube obstruction in mechanically ventilated patients assessed by high-resolution computed tomography. Anesthesiology. 2014 Dec; 121(6):1226-35. PMID: 25254903.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  45. Lyon E, Cockerill FR, Bale SJ, Beadling C, Bry L, Hagenkord J, Kulkarni S, Press R, Palomaki GE. Next generation sequencing in clinical diagnostics: experiences of early adopters. Clin Chem. 2015 Jan; 61(1):41-9. PMID: 25421800.
    Citations:    Fields:    Translation:Humans
  46. Louis DN, Gerber GK, Baron JM, Bry L, Dighe AS, Getz G, Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, Golden JA. Computational pathology: an emerging definition. Arch Pathol Lab Med. 2014 Sep; 138(9):1133-8. PMID: 25171694.
    Citations: 21     Fields:    Translation:Humans
  47. Aziz N, Zhao Q, Bry L, Driscoll DK, Funke B, Gibson JS, Grody WW, Hegde MR, Hoeltge GA, Leonard DG, Merker JD, Nagarajan R, Palicki LA, Robetorye RS, Schrijver I, Weck KE, Voelkerding KV. College of American Pathologists' laboratory standards for next-generation sequencing clinical tests. Arch Pathol Lab Med. 2015 Apr; 139(4):481-93. PMID: 25152313.
    Citations: 101     Fields:    Translation:Humans
  48. Belzer C, Gerber GK, Roeselers G, Delaney M, DuBois A, Liu Q, Belavusava V, Yeliseyev V, Houseman A, Onderdonk A, Cavanaugh C, Bry L. Dynamics of the microbiota in response to host infection. PLoS One. 2014; 9(7):e95534. PMID: 25014551.
    Citations: 23     Fields:    Translation:AnimalsCells
  49. Crawford JM, Bry L, Pfeifer J, Caughron SK, Black-Schaffer S, Kant JA, Kaufman JH. The business of genomic testing: a survey of early adopters. Genet Med. 2014 Dec; 16(12):954-61. PMID: 25010053.
    Citations: 5     Fields:    Translation:Humans
  50. Ghosh P, Vaidya A, Sahoo R, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA. Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans. J Clin Endocrinol Metab. 2014 Jun; 99(6):E999-E1006. PMID: 24628556.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  51. Ghosh P, Sahoo R, Vaidya A, Cantel S, Kavishwar A, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA. A specific and sensitive assay for blood levels of glycated CD59: a novel biomarker for diabetes. Am J Hematol. 2013 Aug; 88(8):670-6. PMID: 23670858.
    Citations: 15     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  52. Cebula A, Seweryn M, Rempala GA, Pabla SS, McIndoe RA, Denning TL, Bry L, Kraj P, Kisielow P, Ignatowicz L. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature. 2013 May 09; 497(7448):258-62. PMID: 23624374.
    Citations: 161     Fields:    Translation:AnimalsCells
  53. Noval Rivas M, Burton OT, Wise P, Zhang YQ, Hobson SA, Garcia Lloret M, Chehoud C, Kuczynski J, DeSantis T, Warrington J, Hyde ER, Petrosino JF, Gerber GK, Bry L, Oettgen HC, Mazmanian SK, Chatila TA. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol. 2013 Jan; 131(1):201-12. PMID: 23201093.
    Citations: 125     Fields:    Translation:AnimalsCellsPHPublic Health
  54. Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 2012 Nov 16; 37(5):930-46. PMID: 23123061.
    Citations: 21     Fields:    Translation:AnimalsCells
  55. Gerber GK, Onderdonk AB, Bry L. Inferring dynamic signatures of microbes in complex host ecosystems. PLoS Comput Biol. 2012; 8(8):e1002624. PMID: 22876171.
    Citations: 27     Fields:    Translation:Humans
  56. Lange NE, Celedón JC, Forno E, Ly NP, Onderdonk A, Bry L, Delaney ML, DuBois AM, Gold DR, Weiss ST, Litonjua AA. Maternal intestinal flora and wheeze in early childhood. Clin Exp Allergy. 2012 Jun; 42(6):901-8. PMID: 22909161.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  57. Dash RC, Robb JA, Booker DL, Foo WC, Witte DL, Bry L. Biospecimens and biorepositories for the community pathologist. Arch Pathol Lab Med. 2012 Jun; 136(6):668-78. PMID: 22646276.
    Citations: 5     Fields:    Translation:Humans
  58. Belzer C, Liu Q, Carroll MC, Bry L. THE ROLE OF SPECIFIC IgG AND COMPLEMENT IN COMBATING A PRIMARY MUCOSAL INFECTION OF THE GUT EPITHELIUM. Eur J Microbiol Immunol (Bp). 2011 Dec; 1(4):311-318. PMID: 22485193.
    Citations: 7     
  59. Kurreeman F, Liao K, Chibnik L, Hickey B, Stahl E, Gainer V, Li G, Bry L, Mahan S, Ardlie K, Thomson B, Szolovits P, Churchill S, Murphy SN, Cai T, Raychaudhuri S, Kohane I, Karlson E, Plenge RM. Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am J Hum Genet. 2011 Jan 07; 88(1):57-69. PMID: 21211616.
    Citations: 60     Fields:    Translation:Humans
  60. Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML, Punit S, Karlsson M, Bry L, Glickman JN, Gordon JI, Onderdonk AB, Glimcher LH. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. . 2010 Sep 16; 8(3):292-300. PMID: 20833380.
    Citations: 341     Translation:AnimalsCells
  61. Murphy S, Churchill S, Bry L, Chueh H, Weiss S, Lazarus R, Zeng Q, Dubey A, Gainer V, Mendis M, Glaser J, Kohane I. Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res. 2009 Sep; 19(9):1675-81. PMID: 19602638.
    Citations: 82     Fields:    Translation:Humans
  62. Bry, L. BWH Clinical Microbiology Manual for CP Residents. 2009.
  63. Mantis, N., Bry, L. The intestinal epithelium: At the Interface between host and pathogen. Immunity against mucosal pathogens. 2008.
  64. Brown MD, Bry L, Li Z, Sacks DB. Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin. J Biol Chem. 2008 Dec 12; 283(50):35212-22. PMID: 18809683.
    Citations: 24     Fields:    Translation:HumansCells
  65. Bry, L. Crimson Project (Word Mark). 2008.
  66. Mantis N., Bry L. The intestinal epithelium: The interface between host and pathogen. 2008.
  67. Baram-Tsbari, A., Sethi, R., Bry, L., Yarden, A. Asking scientists: a decade of questions analyzed by age, gender and country. Science Education. 2008; (In press).
  68. Brown MD, Bry L, Li Z, Sacks DB. IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42. J Biol Chem. 2007 Oct 12; 282(41):30265-72. PMID: 17693642.
    Citations: 32     Fields:    Translation:HumansCells
  69. Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, Blumberg RS. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Invest. 2006 Aug; 116(8):2142-2151. PMID: 16841095.
    Citations: 106     Fields:    Translation:Animals
  70. Ayelet Baram, Ricky Sethi, Lynn Bry, Anat Yarden. Using questions sent to an Ask-A-Scientist site to identify children's interests in science. Science Education. 2006; 90(6):1050-1072.
  71. Bry L, Brigl M, Brenner MB. CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium. Infect Immun. 2006 Jan; 74(1):673-81. PMID: 16369024.
    Citations: 34     Fields:    Translation:AnimalsCells
  72. Bry L. BWH Clinical Microbiology Handbook. 2005. 2005.
  73. Bry L., Vargas SO., McAdam A. The role of Burkholderia cepacia complex infections in patients with cystic fibrosis. CAP Check Survey 2004. 2004; In press.
  74. Bry L. Chapter 12: Prenatal diagnosis and screening of congenital infection. Handbook of Clinical Laboratory Testing During Pregnancy, Ann Gronowski ed. 2004; 245-289.
  75. Lynn Bry. MadSci (Word Mark). 2004.
  76. Bry L, Brenner MB. Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol. 2004 Jan 01; 172(1):433-41. PMID: 14688352.
    Citations: 65     Fields:    Translation:AnimalsCells
  77. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003 Dec; 4(12):1230-7. PMID: 14578883.
    Citations: 278     Fields:    Translation:HumansAnimalsCells
  78. Haspel R., Bry L. . Study Guide, HMS Clerkship PA511M.J Introduction to the Clinical Laboratory. 2003.
  79. Ellerin T.B., Bry L. Cavitary pneumonia caused by Rhodococcus equi in an HIV+ man. J. of Clin. Microbiol. 2003; 41(7):iii.
  80. Bry L. BWH Clinical Microbiology Handbook. 2001.
  81. Bry L, Chen PC, Sacks DB. Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin. Clin Chem. 2001 Feb; 47(2):153-63. PMID: 11159762.
    Citations: 92     Fields:    Translation:Humans
  82. Bry L. Web-based methods for analyzing and processing large volumes of question and answer information. Digital Reference Models for the New Millenium, R. David Lankes, Abby S. Kasowitz Eds. 2000; 54-62.
  83. Bry,\ L. . Study Guide, HMS Clerkship PA511M.J Introduction to the Clinical Laboratory. 1999.
  84. Bry, L. Developing and implementing an Ask-An-Expert Service on the World Wide Web. How to Build and Maintain Digital Reference Services. R. David Lankes and Abby S. Kasowtiz, eds. 1998; 42-48.
  85. Hooper LV, Bry L, Falk PG, Gordon JI. Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. Bioessays. 1998 Apr; 20(4):336-43. PMID: 9619105.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  86. Gordon JI, Hooper LV, McNevin MS, Wong M, Bry L. Epithelial cell growth and differentiation. III. Promoting diversity in the intestine: conversations between the microflora, epithelium, and diffuse GALT. Am J Physiol. 1997 Sep; 273(3 Pt 1):G565-70. PMID: 9316460.
    Citations: 25     Fields:    Translation:HumansAnimals
  87. Bry L, Falk PG, Midtvedt T, Gordon JI. A model of host-microbial interactions in an open mammalian ecosystem. Science. 1996 Sep 06; 273(5280):1380-3. PMID: 8703071.
    Citations: 174     Fields:    Translation:AnimalsCells
  88. Lynn Bry. Tansgenic and Gnotobiotic Models of Host-Microbial Interactions in the Gut. 1996.
  89. Bry L, Falk PG, Gordon JL. Genetic engineering of carbohydrate biosynthetic pathways in transgenic mice demonstrates cell cycle-associated regulation of glycoconjugate production in small intestinal epithelial cells. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1161-6. PMID: 8577733.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  90. Rubio CA, Kanter L, Björk J, Poppen B, Bry L. Paneth cell-rich flat adenoma of the rectum: report of a case. Jpn J Cancer Res. 1996 Jan; 87(1):109-12. PMID: 8609042.
    Citations: 2     Fields:    Translation:Humans
  91. Bry L, Sethi R, Kelly K, et al. MadSci Network: www.madsci.org. 1995.
  92. Falk PG, Bry L, Holgersson J, Gordon JI. Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1515-9. PMID: 7878011.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  93. Bry L, Falk P, Huttner K, Ouellette A, Midtvedt T, Gordon JI. Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10335-9. PMID: 7937951.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.