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Ken Solt, M.D.

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Amherst College, Amherst, MAB.A.05/1996Chemistry
University of Pennsylvania, Philadelphia, PAM.D.05/2000Medicine
Massachusetts General Hospital, Boston, MA09/2004Anesthesiology

I study the mechanisms of emergence and cognitive recovery from general anesthesia using a systems neuroscience approach. In current clinical practice, emergence from general anesthesia is treated as a passive process dictated by the pharmacokinetics of anesthetic drug clearance. My group discovered that dopamine agonists induce active emergence from general anesthesia, and we subsequently discovered that optogenetic stimulation of dopaminergic neurons in the ventral tegmental area (VTA) restores consciousness in anesthetized rodents. I currently direct a translational research program that studies the role of dopamine pathways in restoring consciousness and cognition after general anesthesia. We combine intracranial stimulation, neurophysiological recordings, and cognitive testing in rodents to elucidate the neural circuits that govern anesthetic emergence, and we are actively developing anesthetic reversal agents for clinical use. Our long-term goal is to make general anesthesia safer by developing new therapeutic options for common clinical problems such as delayed emergence, postoperative delirium, and perioperative neurocognitive disorder.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM126155 (SOLT, KEN) Feb 1, 2019 - Nov 30, 2023
    The Anesthetic Circuitry of the Midbrain
    Role: Principal Investigator
  2. P01GM118269 (BROWN, EMERY N.) Feb 10, 2017 - Jan 31, 2022
    Integrated Systems Neuroscience Studies of Anaesthesia
    Role: Principal Investigator
  3. Scholar Award in Understanding Human Cognition (SOLT, KEN) Sep 1, 2014 - Aug 31, 2020
    James S. McDonnell Foundation
    Reanimation and Cognitive Recovery from General Anesthesia
    Role: Principal Investigator
  4. R01GM104948 (BROWN, EMERY N.) Sep 25, 2012 - Aug 31, 2018
    Redesigning General Anesthesia
    Role: Co-Principal Investigator
  5. K08GM094394 (SOLT, KEN) Sep 1, 2010 - Aug 31, 2014
    Active Induction of Emergence from General Anesthesia
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.