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profileSimon Christopher Robson, PH.D., M.B.CH.B.

TitleCharlotte F. and Irving W. Rabb Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
C L S 612
330 Brookline Ave
Boston MA 02215
Phone617/735-2921
Fax617/735-2930
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Available: 07/10/17, Expires: 06/30/18

The major research interests in my laboratory are in purinergic signaling and our focus has been on the vascular and immune ectonucleotidases of the CD39 family. These immune cell signaling pathways are crucial in modulating inflammation and immune responses in the liver and gastrointestinal tract, and are linked to the pathogenesis of inflammatory bowel disease (IBD), non-alcoholic steatohepatitis (NASH) and in the context of progressive liver fibrosis/cirrhosis. Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, currently impacting up to one-third of adults in Western world and beyond. However, only a small proportion of patients exhibit inflammation and progressive liver fibrosis, which leads to cirrhosis and hepatocellular carcinoma. Understanding the pathologic mechanism that drives liver fibrosis is thus essential for the development of urgently needed diagnostic strategies and directing personalized therapeutic approaches. Purines, such as adenosine triphosphate (ATP) and derivatives, arise from nutrient oxidation and provide the energy currency of cells; as well as critical intracellular signaling molecules (e.g. cyclic-AMP). When ATP is released from cells, it can also serve as an essential signaling molecule, modulating inflammation and fibrosis. In the extracellular space, ATP phosphohydrolysis results in adenosine and generation of other nucleosides. We have identified ectonucleotidase activity in the vasculature and immunoregulatory cells and confirmed that CD39 has identity with the ATP or nucleoside triphosphate diphosphohydrolase (EC 3.6.1.5; ENTPD1). Recent work has detailed the functional consequences of plasma membrane expression of CD39 and related family members by endothelium, dendritic cells, regulatory T cells, T helper type 17 (Th17) and natural killer T (NKT) cells. Further, we have developed global and targeted Cd39-deficient mice together with CD39 transgenic mice and pigs. Studies using these mutant animals and biological reagents/drugs that neutralize CD39 bioactivity, indicate that purinergic signals exert major impacts on metabolism, liver function, insulin resistance, as well as impacting survival and end organ injury in models of inflammation and hepatic/intestinal fibrogenesis. The proposed HMS scholarly project will target and define the mechanism of purinergic signaling in regulation of macrophage activation and generation of pro-fibrogenic stimuli in mouse liver models of liver injury and fibrogenesis. Phenotypes of CD39-deficient and wild type mouse macrophages will be studied in vitro and in co-culture with hepatic stellate cells in presence of exogenous ATP/adenosine and other purines. Identification of those myeloid ATP receptors which mediate inflammatory and fibrogenic responses (e.g. P2X7) will be achieved using chemical inhibitors and siRNA screens. Putative fibrogenic/fibrolytic soluble mediators released by macrophages in response to ATP/adenosine will be identified in macrophage/HSC co-culture systems and in vivo models using the unique reagents and mutant mice available in my laboratory. Full details and preliminary data are available on request.

Available: 07/01/17, Expires: 06/30/18

The ectoezyme CD39 scavenges extracellular ATP and ADP, ultimately generating adenosine and resulting in anti-inflammatory effects in the vasculature. We have recently evaluated the role of CD39 in the development of atherosclerosis in setting of hyperlipidemia.

Apolipoprotein E-knockout (Cd39+/+/ApoE-/-, ApoE KO) and Cd39/ApoE double knockout (Cd39-/-/ApoE-/-, DKO) mice were maintained on chow or Western diet for up to 20 weeks before evaluation of atherosclerotic lesions. Surprisingly, we found that DKO mice exhibited significantly less severe disease than the ApoE KO mice, irrespective of diet.

Analyses of plaque composition revealed diminished foam cells in the fatty streaks and smaller necrotic cores in advanced lesions of DKO mice, when compared with those in ApoE KO mice. In vitro studies with either genetic deletion or pharmacological inhibition of CD39, revealed increased ATP-binding cassette transporter A1-mediated cholesterol efflux to apolipoprotein A1 from macrophages.

These data are consistent with augmented effects of extracellular ATP in reverse cholesterol transport and the consequently elevated HDL levels measured in DKO mice. Curiously, no differences in foam cell formation and viability were detected between ApoE KO and DKO macrophages when treated with oxidized LDL.

Our findings indicate that the deficiency of CD39 attenuates atherosclerosis development, which may result from enhanced macrophage cholesterol efflux. We are interested in studying these pathways further.

Modern industrial-type conditions including dioxins, which are found in cigarette smoke and aromatic hydrocarbons increase the risk of developing atherosclerosis in humans, and this has been confirmed experimentally. The prototypic dioxin compound TCDD (2,3,7,8- tetrachlorodibenzo-p-dioxin) binds the aryl hydrocarbon receptor (AhR) and exacerbates atherosclerosis in hyperlipidemic mice, but the mechanism responsible for this have not been identified. We note too that AhR activation up-regulates ectonucleotidases of the CD39 family on immune cells and vascular endothelium in vivo and in vitro.

Hypothesis: Activation of the AhR promotes and exacerbates atherosclerosis by up-regulating CD39 and/or perturbing functions of FoxP3+ Treg and CD39+Th17 cells, and IL-1 production.

Aims are to test:
Whether AhR activation induces atherosclerosis via a CD39-dependent pathway. The requirement for CD39 will be tested by whole body and cell specific deletion as well as bone marrow chimerism. We will also test if CD39 dependent Treg and Th17 cells modify atherosclerosis. The role of AhR activation in the development of these cell types will be tested in vitro and in vivo. In addition the ability of these cell types (wild-type and CD39 null) to contribute to atherosclerosis will be tested by adoptive transfer into Rag2/ApoE double null mice.

Lastly, the student and team will study if the CD39 dependence for atherosclerosis is due to adenosine A2aR/CREB/HIF-1α pathway induced sustained production of IL-1α and IL-1β. The role of this pathway in atherosclerosis will be determined by examining the requirement of sustained activation of macrophages by cholesterol crystals in vitro, and by A2aR agonists in CD39/apolipoprotein E double null mice in vivo. Cell specificity will be established by using macrophage specific A2aR and CD39 null mice.

Collectively these studies will fully test and demonstrate the role of CD39 dependent cellular and molecular pathways that are required for dioxin induced or exacerbated atherosclerosis.

Available: 08/21/17, Expires: 09/30/18

The research interests in my laboratory are in purinergic signaling and our focus has been on the vascular and immune ectonucleotidases of the CD39 family. These signaling pathways are crucial in modulating inflammation and immune responses in the liver and gastrointestinal tract, such as in inflammatory bowel disease (IBD), non-alcoholic steatohepatitis (NASH) and liver fibrosis.

We have identified ectonucleotidase activity in the vasculature and immunoregulatory cells and confirmed that CD39 has identity with the ATP or nucleoside triphosphate diphosphohydrolase (EC 3.6.1.5; ENTPD1). We have developed Cd39-deficient and CD39 transgenic mice and pigs. Over expression of CD39 in transgenic vasculature and immune cells has demonstrated substantive benefits in allo and xenograft function. Modulation of CD39 also impacts survival and in models of inflammation and hepatic/intestinal fibrogenesis.

Recent work has detailed the functional consequences of plasma membrane expression of CD39 and related family members by dendritic cells, regulatory T cells, T helper type 17 (Th17) and natural killer T (NKT) cells.

The proposed HMS scholarly project will target and define the mechanism of purinergic signaling in regulation of macrophage activation and generation of pro-fibrogenic stimuli in mouse liver models of liver injury.

Phenotype of CD39-deficient and wildtype macrophages will be studied in vitro and in co-culture with hepatic stellate cells in presence of exogenous ATP/adenosine. Identification of ATP receptor which mediates hyper-inflammatory responses in absence of Cd39 will be studied (P2X7) using chemical inhibitors and siRNA screens. Putative fibrogenic/fibrolytic soluble mediators released by macrophages in response to ATP/Adenosine will be identified in macrophage/HSC co-culture system using neutralizing antibodies.

Full details and preliminary data are available on request.

Collapse completed student projects
The role of CD39 in the modulation of effector/regulatory cell balance in inflammatory bowel disease
Summer, 06/11/12 - 09/07/12

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21CA164970     (ROBSON, SIMON C)Apr 1, 2012 - Mar 31, 2014
NIH/NCI
Engineering Inhibitory Antibodies to Ectoenzymes for Cancer Treatment
Role: Principal Investigator

R01HL094400     (ROBSON, SIMON C)Jul 1, 2009 - Jun 30, 2012
NIH/NHLBI
Purinergic Thromboregulation
Role: Principal Investigator

U01AI066331     (ROBSON, SIMON C)Jul 1, 2005 - Jun 30, 2011
NIH/NIAID
Thromboregulatory strategies to prolong xenograft survival.
Role: Principal Investigator

P01HL076540     (AIRD, WILLIAM C)Jul 1, 2004 - Jul 31, 2015
NIH/NHLBI
Endothelial Cell Phenotypes in Health and Disease
Role: Co-Principal Investigator

P01AI045897     (SYKES, MEGAN)Sep 1, 2000 - Jul 31, 2021
NIH/NIAID
A Tolerance Approach to Xenotransplantation
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhong AH, Gordon Jiang Z, Cummings RD, Robson SC. Various N-glycoforms differentially upregulate E-NTPDase activity of the NTPDase3/CD39L3 ecto-enzymatic domain. Purinergic Signal. 2017 Sep 27. PMID: 28956227.
    View in: PubMed
  2. Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG. Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease. J Crohns Colitis. 2017 Sep 01; 11(9):1113-1123. PMID: 28472257.
    View in: PubMed
  3. Fried DE, Watson RE, Robson SC, Gulbransen BD. Ammonia modifies enteric neuromuscular transmission through glial gamma-aminobutyric acid signaling. Am J Physiol Gastrointest Liver Physiol. 2017 Aug 24; ajpgi.00154.2017. PMID: 28838986.
    View in: PubMed
  4. Lanser AJ, Rezende RM, Rubino S, Lorello PJ, Donnelly DJ, Xu H, Lau LA, Dulla CG, Caldarone BJ, Robson SC, Weiner HL. Disruption of the ATP/adenosine balance in CD39-/- mice is associated with handling-induced seizures. Immunology. 2017 Jul 25. PMID: 28742222.
    View in: PubMed
  5. Atanasov G, Dietel C, Feldbrügge L, Benzing C, Krenzien F, Brandl A, Mann E, Englisch JP, Schierle K, Robson SC, Splith K, Morgul MH, Reutzel-Selke A, Jonas S, Pascher A, Bahra M, Pratschke J, Schmelzle M. Tumor necrosis and infiltrating macrophages predict survival after curative resection for cholangiocarcinoma. Oncoimmunology. 2017; 6(8):e1331806. PMID: 28919993.
    View in: PubMed
  6. de Andrade Mello P, Bian S, Savio LEB, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017 Sep 15; 8(40):67254-67268. PMID: 28978031.
    View in: PubMed
  7. Mello PA, Bian S, Baggio Savio LE, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017 Jun 21. PMID: 28658673.
    View in: PubMed
  8. Savio LEB, de Andrade Mello P, Figliuolo VR, de Avelar Almeida TF, Santana PT, Oliveira SDS, Silva CLM, Feldbrügge L, Csizmadia E, Minshall RD, Longhi MS, Wu Y, Robson SC, Coutinho-Silva R. CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. J Hepatol. 2017 Oct; 67(4):716-726. PMID: 28554875.
    View in: PubMed
  9. Longhi MS, Moss A, Jiang ZG, Robson SC. Purinergic signaling during intestinal inflammation. J Mol Med (Berl). 2017 May 26. PMID: 28547076.
    View in: PubMed
  10. De Giorgi M, Enjyoji K, Jiang G, Csizmadia E, Mitsuhashi S, Gumina RJ, Smolenski RT, Robson SC. Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice. J Lipid Res. 2017 Jul; 58(7):1292-1305. PMID: 28487312.
    View in: PubMed
  11. Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017 05 04; 2(9). PMID: 28469075.
    View in: PubMed
  12. Zhang H, Chan LL, Rice W, Kassam N, Longhi MS, Zhao H, Robson SC, Gao W, Wu Y. Novel high-throughput cell-based hybridoma screening methodology using the Celigo Image Cytometer. J Immunol Methods. 2017 Aug; 447:23-30. PMID: 28414024.
    View in: PubMed
  13. Sashindranath M, Dwyer KM, Dezfouli S, Selan C, Crikis S, Lu B, Yuan Y, Hickey MJ, Peter K, Robson SC, Cowan PJ, Nandurkar HH. Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury. Purinergic Signal. 2017 Jun; 13(2):259-265. PMID: 28343356.
    View in: PubMed
  14. Yang X, Wu L, Lin J, Wang A, Wan X, Wu Y, Robson SC, Sang X, Zhao H. Distinct hepatitis B virus integration patterns in hepatocellular carcinoma and adjacent normal liver tissue. Int J Cancer. 2017 Mar 15; 140(6):1324-1330. PMID: 27943263.
    View in: PubMed
  15. Allard B, Longhi MS, Robson SC, Stagg J. The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev. 2017 Mar; 276(1):121-144. PMID: 28258700.
    View in: PubMed
  16. Savio LE, Andrade MG, de Andrade Mello P, Santana PT, Moreira-Souza AC, Kolling J, Longoni A, Feldbrügge L, Wu Y, Wyse AT, Robson SC, Coutinho-Silva R. P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction. Mol Neurobiol. 2016 Oct 11. PMID: 27730511.
    View in: PubMed
  17. Miao R, Wu Y, Zhang H, Zhou H, Sun X, Csizmadia E, He L, Zhao Y, Jiang C, Miksad RA, Ghaziani T, Robson SC, Zhao H. Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer. Sci Rep. 2016 Sep 13; 6:33121. PMID: 27618777.
    View in: PubMed
  18. Mahnke K, Useliene J, Ring S, Kage P, Jendrossek V, Robson SC, Bylaite-Bucinskiene M, Steinbrink K, Enk AH. Down-Regulation of CD62L Shedding in T Cells by CD39+ Regulatory T Cells Leads to Defective Sensitization in Contact Hypersensitivity Reactions. J Invest Dermatol. 2017 Jan; 137(1):106-114. PMID: 27623510.
    View in: PubMed
  19. Vaughn BP, Vatanen T, Allegretti JR, Bai A, Xavier RJ, Korzenik J, Gevers D, Ting A, Robson SC, Moss AC. Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease. Inflamm Bowel Dis. 2016 Sep; 22(9):2182-90. PMID: 27542133; PMCID: PMC4995064 [Available on 09/01/17].
  20. Atanasov G, Schierle K, Hau HM, Dietel C, Krenzien F, Brandl A, Wiltberger G, Englisch JP, Robson SC, Reutzel-Selke A, Pascher A, Jonas S, Pratschke J, Benzing C, Schmelzle M. Prognostic Significance of Tumor Necrosis in Hilar Cholangiocarcinoma. Ann Surg Oncol. 2017 Feb; 24(2):518-525. PMID: 27480355.
    View in: PubMed
  21. Covarrubias R, Chepurko E, Reynolds A, Huttinger ZM, Huttinger R, Stanfill K, Wheeler DG, Novitskaya T, Robson SC, Dwyer KM, Cowan PJ, Gumina RJ. Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice. Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9):1809-20. PMID: 27417582.
    View in: PubMed
  22. Wu L, Bai X, Xie Y, Yang Z, Yang X, Lin J, Zhu C, Wang A, Zhang H, Miao R, Wu Y, Robson SC, Zhao Y, Sang X, Zhao H. MetastamiRs: A promising choice for antihepatocellular carcinoma nucleic acid drug development. Hepatol Res. 2017 Jan; 47(1):80-94. PMID: 27138942.
    View in: PubMed
  23. Mitsuhashi S, Feldbrügge L, Csizmadia E, Mitsuhashi M, Robson SC, Moss AC. Luminal Extracellular Vesicles (EVs) in Inflammatory Bowel Disease (IBD) Exhibit Proinflammatory Effects on Epithelial Cells and Macrophages. Inflamm Bowel Dis. 2016 Jul; 22(7):1587-95. PMID: 27271497; PMCID: PMC4911338 [Available on 07/01/17].
  24. Gubatan J, Mitsuhashi S, Zenlea T, Rosenberg L, Robson S, Moss AC. Low Serum Vitamin D During Remission Increases Risk of Clinical Relapse in Patients With Ulcerative Colitis. Clin Gastroenterol Hepatol. 2017 Feb; 15(2):240-246.e1. PMID: 27266980.
    View in: PubMed
  25. Takenaka MC, Robson S, Quintana FJ. Regulation of the T Cell Response by CD39. Trends Immunol. 2016 Jul; 37(7):427-39. PMID: 27236363.
    View in: PubMed
  26. Robson S, Willmott GR. Asymmetries in the spread of drops impacting on hydrophobic micropillar arrays. Soft Matter. 2016 May 25; 12(21):4853-65. PMID: 27140067.
    View in: PubMed
  27. Liberal R, Grant CR, Ma Y, Csizmadia E, Jiang ZG, Heneghan MA, Yee EU, Mieli-Vergani G, Vergani D, Robson SC, Longhi MS. CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease. J Autoimmun. 2016 Aug; 72:102-12. PMID: 27210814.
    View in: PubMed
  28. Atanasov G, Hau HM, Dietel C, Benzing C, Krenzien F, Brandl A, Englisch JP, Wiltberger G, Schierle K, Robson SC, Reutzel-Selke A, Jonas S, Pascher A, Pratschke J, Schmelzle M. Prognostic significance of TIE2-expressing monocytes in hilar cholangiocarcinoma. J Surg Oncol. 2016 Jul; 114(1):91-8. PMID: 27111031.
    View in: PubMed
  29. Schulte am Esch J, Schmelzle M, Duhme C, Fuerst G, Robson SC, Bode JG, Krieg A, Topp SA, Haeussinger D, Knoefel WT. Reply to Letter: "Infusion of CD133+ Bone Marrow-Derived Stem Cell After Selective Portal Vein Embolization Enhances Functional Hepatic Reserves After Extended Right Hepatectomy". Ann Surg. 2016 Mar; 263(3):e44-5. PMID: 25894409; PMCID: PMC4609212 [Available on 03/01/17].
  30. Homola M, Pfeffer M, Robson SC, Fischer C, Zimmermann H, Korf HW. Melatonin receptor deficiency decreases and temporally shifts ecto-5'-nucleotidase mRNA levels in mouse prosencephalon. Cell Tissue Res. 2016 Jul; 365(1):147-56. PMID: 26917036.
    View in: PubMed
  31. Jiang ZG, Tapper EB, Connelly MA, Pimentel CF, Feldbrügge L, Kim M, Krawczyk S, Afdhal N, Robson SC, Herman MA, Otvos JD, Mukamal KJ, Lai M. Steatohepatitis and liver fibrosis are predicted by the characteristics of very low density lipoprotein in nonalcoholic fatty liver disease. Liver Int. 2016 Aug; 36(8):1213-20. PMID: 26815314; PMCID: PMC4942367.
  32. Gibson DJ, Elliott L, McDermott E, Tosetto M, Keegan D, Byrne K, Martin ST, Rispens T, Cullen G, Mulcahy HE, Cheifetz AS, Moss AC, Robson SC, Doherty GA, Ryan EJ. Heightened Expression of CD39 by Regulatory T Lymphocytes Is Associated with Therapeutic Remission in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015 Dec; 21(12):2806-14. PMID: 26332314.
    View in: PubMed
  33. Bai A, Moss A, Rothweiler S, Longhi MS, Wu Y, Junger WG, Robson SC. NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine. Nat Commun. 2015 Nov 09; 6:8819. PMID: 26549640; PMCID: PMC4667632.
  34. Lazar Z, Müllner N, Lucattelli M, Ayata CK, Cicko S, Yegutkin GG, De Cunto G, Müller T, Meyer A, Hossfeld M, Sorichter S, Horvath I, Virchow CJ, Robson SC, Lungarella G, Idzko M. NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD. Eur Respir J. 2016 Jan; 47(1):254-63. PMID: 26541524.
    View in: PubMed
  35. Atanasov G, Hau HM, Dietel C, Benzing C, Krenzien F, Brandl A, Wiltberger G, Matia I, Prager I, Schierle K, Robson SC, Reutzel-Selke A, Pratschke J, Schmelzle M, Jonas S. Prognostic significance of macrophage invasion in hilar cholangiocarcinoma. BMC Cancer. 2015 Oct 24; 15:790. PMID: 26497197; PMCID: PMC4620011.
  36. Jiang ZG, de Boer IH, Mackey RH, Jensen MK, Lai M, Robson SC, Tracy R, Kuller LH, Mukamal KJ. Associations of insulin resistance, inflammation and liver synthetic function with very low-density lipoprotein: The Cardiovascular Health Study. Metabolism. 2016 Mar; 65(3):92-9. PMID: 26892520; PMCID: PMC4761104 [Available on 03/01/17].
  37. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. PMID: 26485519; PMCID: PMC4618999.
  38. Pimentel CF, Jiang ZG, Otsubo T, Feldbrügge L, Challies TL, Nasser I, Robson S, Afdhal N, Lai M. Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH. Dig Dis Sci. 2016 Mar; 61(3):905-12. PMID: 26462489; PMCID: PMC4761280 [Available on 03/01/17].
  39. Ferrari D, Gambari R, Idzko M, Müller T, Albanesi C, Pastore S, La Manna G, Robson SC, Cronstein B. Purinergic signaling in scarring. FASEB J. 2016 Jan; 30(1):3-12. PMID: 26333425; PMCID: PMC4684510 [Available on 01/01/17].
  40. Nowak-Machen M, Lange M, Exley M, Wu S, Usheva A, Robson SC. Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury. Purinergic Signal. 2015 Dec; 11(4):455-61. PMID: 26306905; PMCID: PMC4648788 [Available on 02/26/16].
  41. Cowan PJ, Robson SC. Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation. Int J Surg. 2015 Nov; 23(Pt B):296-300. PMID: 26220018.
    View in: PubMed
  42. Ledderose C, Bao Y, Ledderose S, Woehrle T, Heinisch M, Yip L, Zhang J, Robson SC, Shapiro NI, Junger WG. Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis. 2016 Feb 01; 213(3):456-64. PMID: 26150546; PMCID: PMC4704665 [Available on 02/01/17].
  43. Bai A, Robson S. Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161. Purinergic Signal. 2015 Sep; 11(3):317-9. PMID: 26059452; PMCID: PMC4529856.
  44. Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-a. Nat Med. 2015 Jun; 21(6):638-46. PMID: 26005855; PMCID: PMC4476246.
  45. Homola M, Pfeffer M, Fischer C, Zimmermann H, Robson SC, Korf HW. Expression of ectonucleotidases in the prosencephalon of melatonin-proficient C3H and melatonin-deficient C57Bl mice: spatial distribution and time-dependent changes. Cell Tissue Res. 2015 Oct; 362(1):163-76. PMID: 25959293.
    View in: PubMed
  46. Zhang Y, Robson SC, Morris KL, Heiney KM, Dwyer KM, Kishore BK, Ecelbarger CM. Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1). Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1398-408. PMID: 25877509; PMCID: PMC4469885.
  47. Ring S, Pushkarevskaya A, Schild H, Probst HC, Jendrossek V, Wirsdörfer F, Ledent C, Robson SC, Enk AH, Mahnke K. Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway. J Immunol. 2015 Apr 15; 194(8):3735-44. PMID: 25780038.
    View in: PubMed
  48. Todd JN, Poon W, Lyssenko V, Groop L, Nichols B, Wilmot M, Robson S, Enjyoji K, Herman MA, Hu C, Zhang R, Jia W, Ma R, Florez JC, Friedman DJ. Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans. J Clin Endocrinol Metab. 2015 May; 100(5):E688-96. PMID: 25719930; PMCID: PMC4422893.
  49. Yoshida O, Dou L, Kimura S, Yokota S, Isse K, Robson SC, Geller DA, Thomson AW. CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection. Transpl Immunol. 2015 Mar; 32(2):76-83. PMID: 25661084; PMCID: PMC4368493.
  50. Grant CR, Liberal R, Ma Y, Robson SC, Mieli-Vergani G, Vergani D, Longhi MS. Reply: To PMID 23787765. Hepatology. 2015 Feb; 61(2):737-8. PMID: 25042541.
    View in: PubMed
  51. Gampe K, Stefani J, Hammer K, Brendel P, Pötzsch A, Enikolopov G, Enjyoji K, Acker-Palmer A, Robson SC, Zimmermann H. NTPDase2 and purinergic signaling control progenitor cell proliferation in neurogenic niches of the adult mouse brain. Stem Cells. 2015 Jan; 33(1):253-64. PMID: 25205248; PMCID: PMC4270857 [Available on 01/01/16].
  52. Gampe K, Haverkamp S, Robson SC, Gachet C, Hüser L, Acker-Palmer A, Zimmermann H. NTPDase2 and the P2Y1 receptor are not required for mammalian eye formation. Purinergic Signal. 2015 Mar; 11(1):155-60. PMID: 25504514; PMCID: PMC4336302.
  53. William JH, Tapper EB, Yee EU, Robson SC. Secondary kwashiorkor: a rare complication of gastric bypass surgery. Am J Med. 2015 May; 128(5):e1-2. PMID: 25498166.
    View in: PubMed
  54. Jiang ZG, Wu Y, Csizmadia E, Feldbrügge L, Enjyoji K, Tigges J, Toxavidis V, Stephan H, Müller CE, McKnight CJ, Moss A, Robson SC. Erratum to: Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma. Purinergic Signal. 2014 Dec; 10(4):855. PMID: 25301668.
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  55. Csóka B, Németh ZH, Töro G, Koscsó B, Kókai E, Robson SC, Enjyoji K, Rolandelli RH, Erdélyi K, Pacher P, Haskó G. CD39 improves survival in microbial sepsis by attenuating systemic inflammation. FASEB J. 2015 Jan; 29(1):25-36. PMID: 25318479; PMCID: PMC4285550.
  56. Yu W, Sun X, Robson SC, Hill WG. ADP-induced bladder contractility is mediated by P2Y12 receptor and temporally regulated by ectonucleotidases and adenosine signaling. FASEB J. 2014 Dec; 28(12):5288-98. PMID: 25208846; PMCID: PMC4232283.
  57. Azimzadeh AM, Byrne GW, Ezzelarab M, Welty E, Braileanu G, Cheng X, Robson SC, McGregor CG, Cooper DK, Pierson RN. Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells. Xenotransplantation. 2014 Nov-Dec; 21(6):555-66. PMID: 25176173; PMCID: PMC4262663.
  58. Bai A, Moss A, Kokkotou E, Usheva A, Sun X, Cheifetz A, Zheng Y, Longhi MS, Gao W, Wu Y, Robson SC. CD39 and CD161 modulate Th17 responses in Crohn's disease. J Immunol. 2014 Oct 01; 193(7):3366-77. PMID: 25172498; PMCID: PMC4170017.
  59. Jiang ZG, Wu Y, Csizmadia E, Feldbrügge L, Enjyoji K, Tigges J, Toxavidis V, Stephan H, Müller CE, Müller CE, McKnight CJ, Moss A, Robson SC. Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma. Purinergic Signal. 2014 Dec; 10(4):611-8. PMID: 25165006; PMCID: PMC4272360.
  60. Moeckel D, Jeong SS, Sun X, Broekman MJ, Nguyen A, Drosopoulos JH, Marcus AJ, Robson SC, Chen R, Abendschein D. Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk. Sci Transl Med. 2014 Aug 06; 6(248):248ra105. PMID: 25100739; PMCID: PMC4291186.
  61. Yeh H, Machaidze Z, Wamala I, Fraser JW, Navarro-Alvarez N, Kim K, Schuetz C, Shi S, Zhu A, Hertl M, Elias N, Farkash EA, Vagefi PA, Varma M, Smith RN, Robson SC, Van Cott EM, Sachs DH, Markmann JF. Increased transfusion-free survival following auxiliary pig liver xenotransplantation. Xenotransplantation. 2014 Sep-Oct; 21(5):454-64. PMID: 25130043.
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  62. Roberts VS, Cowan PJ, Alexander SI, Robson SC, Dwyer KM. The role of adenosine receptors A2A and A2B signaling in renal fibrosis. Kidney Int. 2014 Oct; 86(4):685-92. PMID: 25054776.
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  63. Wang Y, Telesford KM, Ochoa-Repáraz J, Haque-Begum S, Christy M, Kasper EJ, Wang L, Wu Y, Robson SC, Kasper DL, Kasper LH. An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling. Nat Commun. 2014 Jul 21; 5:4432. PMID: 25043484; PMCID: PMC4118494.
  64. Vaughn BP, Robson SC, Longhi MS. Purinergic signaling in liver disease. Dig Dis. 2014; 32(5):516-24. PMID: 25034284.
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  65. Vabres B, Le Bas-Bernardet S, Riochet D, Chérel Y, Minault D, Hervouet J, Ducournau Y, Moreau A, Daguin V, Coulon F, Pallier A, Brouard S, Robson SC, Nottle MB, Cowan PJ, Venturi E, Mermillod P, Brachet P, Galli C, Lagutina I, Duchi R, Bach JM, Blancho G, Soulillou JP, Vanhove B. hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model. Xenotransplantation. 2014 Sep-Oct; 21(5):431-43. PMID: 25040113.
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  66. Wang Y, Begum-Haque S, Telesford KM, Ochoa-Repáraz J, Christy M, Kasper EJ, Kasper DL, Robson SC, Kasper LH. A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation. Gut Microbes. 2014 Jul 01; 5(4):552-61. PMID: 25006655.
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  67. Miao R, Luo H, Zhou H, Li G, Bu D, Yang X, Zhao X, Zhang H, Liu S, Zhong Y, Zou Z, Zhao Y, Yu K, He L, Sang X, Zhong S, Huang J, Wu Y, Miksad RA, Robson SC, Jiang C, Zhao Y, Zhao H. Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis. J Hepatol. 2014 Oct; 61(4):840-9. PMID: 24859455.
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  68. Ham M, Longhi MS, Lahiff C, Cheifetz A, Robson S, Moss AC. Vitamin D levels in adults with Crohn's disease are responsive to disease activity and treatment. Inflamm Bowel Dis. 2014 May; 20(5):856-60. PMID: 24681654; PMCID: PMC4077052.
  69. Malo MS, Moaven O, Muhammad N, Biswas B, Alam SN, Economopoulos KP, Gul SS, Hamarneh SR, Malo NS, Teshager A, Mohamed MM, Tao Q, Narisawa S, Millán JL, Hohmann EL, Warren HS, Robson SC, Hodin RA. Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. Am J Physiol Gastrointest Liver Physiol. 2014 May 15; 306(10):G826-38. PMID: 24722905; PMCID: PMC4024727.
  70. Gong W, Ge F, Liu D, Wu Y, Liu F, Kim BS, Huang T, Koulmanda M, Robson SC, Strom TB. Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model. Clin Immunol. 2014 Jul; 153(1):8-16. PMID: 24691417.
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  71. Longhi MS, Moss A, Bai A, Wu Y, Huang H, Cheifetz A, Quintana FJ, Robson SC. Characterization of human CD39+ Th17 cells with suppressor activity and modulation in inflammatory bowel disease. PLoS One. 2014; 9(2):e87956. PMID: 24505337; PMCID: PMC3914873.
  72. Grant CR, Liberal R, Holder BS, Cardone J, Ma Y, Robson SC, Mieli-Vergani G, Vergani D, Longhi MS. Dysfunctional CD39(POS) regulatory T cells and aberrant control of T-helper type 17 cells in autoimmune hepatitis. Hepatology. 2014 Mar; 59(3):1007-15. PMID: 23787765.
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  73. Jiang ZG, Mukamal K, Tapper E, Robson SC, Tsugawa Y. Low LDL-C and high HDL-C levels are associated with elevated serum transaminases amongst adults in the United States: a cross-sectional study. PLoS One. 2014; 9(1):e85366. PMID: 24454851; PMCID: PMC3893181.
  74. Kapila N, Higa JT, Longhi MS, Robson SC. Autoimmune Hepatitis: Clinical Review with Insights into the Purinergic Mechanism of Disease. J Clin Transl Hepatol. 2013 Dec; 1(2):79-86. PMID: 26356124; PMCID: PMC4521285.
  75. Safaie P, Ham M, Kuang P, Mehta AS, Wang M, Cheifetz AS, Robson S, Lau D, Block TM, Moss AC. Lectin-reactive anti-a-gal in patients with Crohn's disease: correlation with clinical phenotypes. Inflamm Bowel Dis. 2013 Dec; 19(13):2796-800. PMID: 24185312; PMCID: PMC4112456.
  76. Fernández P, Perez-Aso M, Smith G, Wilder T, Trzaska S, Chiriboga L, Franks A, Robson SC, Cronstein BN, Chan ES. Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis. Am J Pathol. 2013 Dec; 183(6):1740-6. PMID: 24266925.
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  77. Burnstock G, Vaughn B, Robson SC. Purinergic signalling in the liver in health and disease. Purinergic Signal. 2014 Mar; 10(1):51-70. PMID: 24271096; PMCID: PMC3944046.
  78. Jangi S, Otterbein L, Robson S. The molecular basis for the immunomodulatory activities of unconjugated bilirubin. Int J Biochem Cell Biol. 2013 Dec; 45(12):2843-51. PMID: 24144577.
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  79. Yoshida O, Kimura S, Jackson EK, Robson SC, Geller DA, Murase N, Thomson AW. CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice. Hepatology. 2013 Dec; 58(6):2163-75. PMID: 23813862; PMCID: PMC3844081.
  80. Pintore L, Paltrinieri S, Vadori M, Besenzon F, Cavicchioli L, De Benedictis GM, Calabrese F, Cozzi E, Nottle MB, Robson SC, Cowan PJ, Castagnaro M. Clinicopathological findings in non-human primate recipients of porcine renal xenografts: quantitative and qualitative evaluation of proteinuria. Xenotransplantation. 2013 Nov-Dec; 20(6):449-57. PMID: 24112104.
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  81. Yoshida S, Kornek M, Ikenaga N, Schmelzle M, Masuzaki R, Csizmadia E, Wu Y, Robson SC, Schuppan D. Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma. Hepatology. 2013 Nov; 58(5):1667-80. PMID: 23729316.
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  82. Byrne GW, Azimzadeh AM, Ezzelarab M, Tazelaar HD, Ekser B, Pierson RN, Robson SC, Cooper DK, McGregor CG. Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection. Xenotransplantation. 2013 Sep-Oct; 20(5):292-307. PMID: 25098626; PMCID: PMC4126170.
  83. Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013 Oct; 14(10):1054-63. PMID: 23995234; PMCID: PMC3964005.
  84. Vandenbeuch A, Anderson CB, Parnes J, Enjyoji K, Robson SC, Finger TE, Kinnamon SC. Role of the ectonucleotidase NTPDase2 in taste bud function. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14789-94. PMID: 23959882; PMCID: PMC3767538.
  85. Westall GP, Levvey BJ, Salvaris E, Gooi J, Marasco S, Rosenfeldt F, Egan C, McEgan Ccp R, Mennen M, Russell P, Robson SC, Nottle MB, Dwyer KM, Snell GI, Cowan PJ. Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation. J Heart Lung Transplant. 2013 Nov; 32(11):1123-30. PMID: 23932853.
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  86. Cohen HB, Briggs KT, Marino JP, Ravid K, Robson SC, Mosser DM. TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses. Blood. 2013 Sep 12; 122(11):1935-45. PMID: 23908469; PMCID: PMC3772500.
  87. Pettengill M, Robson S, Tresenriter M, Millán JL, Usheva A, Bingham T, Belderbos M, Bergelson I, Burl S, Kampmann B, Gelinas L, Kollmann T, Bont L, Levy O. Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. J Biol Chem. 2013 Sep 20; 288(38):27315-26. PMID: 23897810; PMCID: PMC3779727.
  88. Tapper EB, Robson S, Malik R. Reply to: "Circulating platelet derived microparticles are not increased in patients with cirrhosis". J Hepatol. 2013 Oct; 59(4):913. PMID: 23816703.
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  89. Cohen J, Hariton E, Kothari D, Pihan GA, Robson SC. Hepatosplenic alpha/beta T-cell lymphoma masquerading as cirrhosis. J Gastrointest Oncol. 2013 Jun; 4(2):131-6. PMID: 23730508; PMCID: PMC3635184.
  90. Lehwald N, Duhme C, Wildner M, Kuhn S, Fürst G, Forbes SJ, Jonas S, Robson SC, Knoefel WT, Schmelzle M, Schulte Am Esch J. HGF and SDF-1-mediated mobilization of CD133+ BMSC for hepatic regeneration following extensive liver resection. Liver Int. 2014 Jan; 34(1):89-101. PMID: 23701640.
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  91. Tapper EB, Robson SC, Malik R. Coagulopathy in cirrhosis - the role of the platelet in hemostasis. J Hepatol. 2013 Oct; 59(4):889-90. PMID: 23669288.
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  92. Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC. Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):601-9. PMID: 23349052; PMCID: PMC3707383.
  93. Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, Junger WG, Robson SC, Wu Y. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS One. 2013; 8(4):e60184. PMID: 23565201; PMCID: PMC3615040.
  94. Schmelzle M, Duhme C, Junger W, Salhanick SD, Chen Y, Wu Y, Toxavidis V, Csizmadia E, Han L, Bian S, Fürst G, Nowak M, Karp SJ, Knoefel WT, Esch JSA, Robson SC. CD39 modulates hematopoietic stem cell recruitment and promotes liver regeneration in mice and humans after partial hepatectomy. Ann Surg. 2013 Apr; 257(4):693-701. PMID: 23474584; PMCID: PMC4243517.
  95. Eltzschig HK, Sitkovsky MV, Robson SC. Purinergic signaling during inflammation. N Engl J Med. 2013 Mar 28; 368(13):1260. PMID: 23534573.
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  96. Pommey S, Lu B, McRae J, Stagg J, Hill P, Salvaris E, Robson SC, d'Apice AJ, Cowan PJ, Dwyer KM. Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells. Hepatology. 2013 Apr; 57(4):1597-606. PMID: 22829222.
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  97. Rosenberg L, Lawlor GO, Zenlea T, Goldsmith JD, Gifford A, Falchuk KR, Wolf JL, Cheifetz AS, Robson SC, Moss AC. Predictors of endoscopic inflammation in patients with ulcerative colitis in clinical remission. Inflamm Bowel Dis. 2013 Mar-Apr; 19(4):779-84. PMID: 23446338; PMCID: PMC3749843.
  98. Chia JS, McRae JL, Thomas HE, Fynch S, Elkerbout L, Hill P, Murray-Segal L, Robson SC, Chen JF, d'Apice AJ, Cowan PJ, Dwyer KM. The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice. Diabetes. 2013 Jun; 62(6):2026-35. PMID: 23364452; PMCID: PMC3661652.
  99. Yu W, Sun X, Robson SC, Hill WG. Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J. 2013 May; 27(5):1895-903. PMID: 23362118; PMCID: PMC3633826.
  100. Graubardt N, Fahrner R, Trochsler M, Keogh A, Breu K, Furer C, Stroka D, Robson SC, Slack E, Candinas D, Beldi G. Promotion of liver regeneration by natural killer cells in a murine model is dependent on extracellular adenosine triphosphate phosphohydrolysis. Hepatology. 2013 May; 57(5):1969-79. PMID: 22898900.
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  101. Schmelzle M, Splith K, Andersen LW, Kornek M, Schuppan D, Jones-Bamman C, Nowak M, Toxavidis V, Salhanick SD, Han L, Schulte am Esch J, Jonas S, Donnino MW, Robson SC. Increased plasma levels of microparticles expressing CD39 and CD133 in acute liver injury. Transplantation. 2013 Jan 15; 95(1):63-9. PMID: 23232366; PMCID: PMC3536489.
  102. Yang Z, Miao R, Li G, Wu Y, Robson SC, Yang X, Zhao Y, Zhao H, Zhong Y. Identification of recurrence related microRNAs in hepatocellular carcinoma after surgical resection. Int J Mol Sci. 2013 Jan 08; 14(1):1105-18. PMID: 23299437; PMCID: PMC3565310.
  103. Longhi MS, Robson SC, Bernstein SH, Serra S, Deaglio S. Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states. J Mol Med (Berl). 2013 Feb; 91(2):165-72. PMID: 23292173; PMCID: PMC4266600.
  104. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology. 2013 Jan; 57(1):205-16. PMID: 22859060; PMCID: PMC3505255.
  105. Eltzschig HK, Sitkovsky MV, Robson SC. Purinergic signaling during inflammation. N Engl J Med. 2012 Dec 13; 367(24):2322-33. PMID: 23234515; PMCID: PMC3675791.
  106. Bulavina L, Szulzewsky F, Rocha A, Krabbe G, Robson SC, Matyash V, Kettenmann H. NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal. 2013 Jun; 9(2):199-205. PMID: 23208703; PMCID: PMC3646122.
  107. Matar AJ, Crepeau RL, Pathiraja V, Robson S, Fishman JA, Spitzer TR, Sachs DH, Huang CA, Duran-Struuck R. Effects of mobilization regimens in donors on outcomes of hematopoietic cell transplantation in miniature Swine. Comp Med. 2012 Dec; 62(6):487-94. PMID: 23561882; PMCID: PMC3527753.
  108. Jiang ZG, Robson SC, Yao Z. Lipoprotein metabolism in nonalcoholic fatty liver disease. J Biomed Res. 2013 Jan; 27(1):1-13. PMID: 23554788; PMCID: PMC3596749.
  109. Doherty GA, Bai A, Hanidziar D, Longhi MS, Lawlor GO, Putheti P, Csizmadia E, Nowak M, Cheifetz AS, Moss AC, Robson SC. CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease. Eur J Immunol. 2012 Nov; 42(11):3062-72. PMID: 22965858; PMCID: PMC3556646.
  110. Zhao X, Yang Z, Li G, Li D, Zhao Y, Wu Y, Robson SC, He L, Xu Y, Miao R, Zhao H. The role and clinical implications of microRNAs in hepatocellular carcinoma. Sci China Life Sci. 2012 Oct; 55(10):906-19. PMID: 23108868.
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  111. Peng Q, Yeh H, Wei L, Enjyoj K, Machaidze Z, Csizmad E, Schuetz C, Lee KM, Deng S, Robson SC, Markmann J, Buhler L. Mechanisms of xenogeneic baboon platelet aggregation and phagocytosis by porcine liver sinusoidal endothelial cells. PLoS One. 2012; 7(10):e47273. PMID: 23118867; PMCID: PMC3484054.
  112. Wang X, Cui Y, Luo G, Wang Q, Hu J, He W, Yuan J, Zhou J, Wu Y, Sun X, Robson SC, Li X, Tan J, Peng Y, Xue G, Lu L, Gao W, Wu J. Activated mouse CD4(+)Foxp3(-) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity. Cell Res. 2012 Dec; 22(12):1696-706. PMID: 22945357; PMCID: PMC3515753.
  113. Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI. Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012 Sep; 42(9):2441-51. PMID: 22684996.
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  114. Ekser B, Burlak C, Waldman JP, Lutz AJ, Paris LL, Veroux M, Robson SC, Rees MA, Ayares D, Gridelli B, Tector AJ, Cooper DK. Immunobiology of liver xenotransplantation. Expert Rev Clin Immunol. 2012 Sep; 8(7):621-34. PMID: 23078060; PMCID: PMC3774271.
  115. Crepeau R, Matar A, Spitzer TR, Robson S, Pathiraja V, Sachs DH, Huang CA, Duran-Struuck R. Edema and tetraparesis in a miniature pig after allogeneic hematopoietic cell transplantation. Comp Med. 2012 Aug; 62(4):298-302. PMID: 23043783; PMCID: PMC3415372.
  116. Kim K, Schuetz C, Elias N, Veillette GR, Wamala I, Varma M, Smith RN, Robson SC, Cosimi AB, Sachs DH, Hertl M. Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons. Xenotransplantation. 2012 Jul-Aug; 19(4):256-64. PMID: 22909139; PMCID: PMC3655405.
  117. Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, Brinkoetter MT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D, Mantzoros CS. Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut. 2013 Apr; 62(4):561-70. PMID: 22735569.
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  118. Vaughn BP, Robson SC, Burnstock G. Pathological roles of purinergic signaling in the liver. J Hepatol. 2012 Oct; 57(4):916-20. PMID: 22709619; PMCID: PMC3732799.
  119. Tapper E, Schmelzle M, Eltzschig HK, Robson SC. Erratum to: Role of CD73 and extracellular adenosine in disease : Presented by Maria P. Abbracchio. Purinergic Signal. 2012 Jun; 8(2):339. PMID: 22183752.
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  120. Ekser B, Lin CC, Long C, Echeverri GJ, Hara H, Ezzelarab M, Bogdanov VY, Stolz DB, Enjyoji K, Robson SC, Ayares D, Dorling A, Cooper DK, Gridelli B. Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation. Transpl Int. 2012 Aug; 25(8):882-96. PMID: 22642260; PMCID: PMC3394909.
  121. Yegutkin GG, Wieringa B, Robson SC, Jalkanen S. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J. 2012 Sep; 26(9):3875-83. PMID: 22637533; PMCID: PMC3425827.
  122. Zhang Y, Morris KL, Sparrow SK, Dwyer KM, Enjyoji K, Robson SC, Kishore BK. Defective renal water handling in transgenic mice over-expressing human CD39/NTPDase1. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F420-30. PMID: 22622462; PMCID: PMC3433867.
  123. Huttinger ZM, Milks MW, Nickoli MS, Aurand WL, Long LC, Wheeler DG, Dwyer KM, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice. Am J Pathol. 2012 Jul; 181(1):322-33. PMID: 22613024; PMCID: PMC3388153.
  124. Cooper DK, Ekser B, Burlak C, Ezzelarab M, Hara H, Paris L, Tector AJ, Phelps C, Azimzadeh AM, Ayares D, Robson SC, Pierson RN. Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation. 2012 May-Jun; 19(3):144-58. PMID: 22702466; PMCID: PMC3775598.
  125. Chalmin F, Mignot G, Bruchard M, Chevriaux A, Végran F, Hichami A, Ladoire S, Derangère V, Vincent J, Masson D, Robson SC, Eberl G, Pallandre JR, Borg C, Ryffel B, Apetoh L, Rébé C, Ghiringhelli F. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity. 2012 Mar 23; 36(3):362-73. PMID: 22406269.
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  126. Banz Y, Hess OM, Meier P, Korchagina EY, Gordeeva EA, Robson SC, Gajanayake T, Csizmadia E, Mettler D, Haeberli A, Bovin NV, Rieben R. Evaluation of multimeric tyrosine-O-sulfate as a cytoprotectant in an in vivo model of acute myocardial infarction in pigs. Cardiology. 2012; 121(1):59-70. PMID: 22398380.
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  127. Hoque R, Sohail MA, Salhanick S, Malik AF, Ghani A, Robson SC, Mehal WZ. P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice. Am J Physiol Gastrointest Liver Physiol. 2012 May 15; 302(10):G1171-9. PMID: 22383490; PMCID: PMC3362096.
  128. Longhi MS, Liberal R, Holder B, Robson SC, Ma Y, Mieli-Vergani G, Vergani D. Inhibition of interleukin-17 promotes differentiation of CD25? cells into stable T regulatory cells in patients with autoimmune hepatitis. Gastroenterology. 2012 Jun; 142(7):1526-35.e6. PMID: 22387392.
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  129. Wheeler DG, Joseph ME, Mahamud SD, Aurand WL, Mohler PJ, Pompili VJ, Dwyer KM, Nottle MB, Harrison SJ, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Transgenic swine: expression of human CD39 protects against myocardial injury. J Mol Cell Cardiol. 2012 May; 52(5):958-61. PMID: 22269791; PMCID: PMC3327755.
  130. O'Keeffe MG, Thorne PR, Housley GD, Robson SC, Vlajkovic SM. Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction. J Vestib Res. 2012; 22(5-6):213-9. PMID: 23302703.
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  131. Scalea J, Hanecamp I, Robson SC, Yamada K. T-cell-mediated immunological barriers to xenotransplantation. Xenotransplantation. 2012 Jan-Feb; 19(1):23-30. PMID: 22360750; PMCID: PMC3786340.
  132. am Esch JS, Schmelzle M, Fürst G, Robson SC, Krieg A, Duhme C, Tustas RY, Alexander A, Klein HM, Topp SA, Bode JG, Häussinger D, Eisenberger CF, Knoefel WT. Infusion of CD133+ bone marrow-derived stem cells after selective portal vein embolization enhances functional hepatic reserves after extended right hepatectomy: a retrospective single-center study. Ann Surg. 2012 Jan; 255(1):79-85. PMID: 22156926.
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  133. Robson SC. Role of CD73 and extracellular adenosine in disease : Presented by Maria P. Abbracchio. Purinergic Signal. 2011 Dec; 7(4):367-72. PMID: 22052554; PMCID: PMC3224638.
  134. Shimizu A, Yamada K, Robson SC, Sachs DH, Colvin RB. Pathologic characteristics of transplanted kidney xenografts. J Am Soc Nephrol. 2012 Feb; 23(2):225-35. PMID: 22114174; PMCID: PMC3269172.
  135. Braganhol E, Zanin RF, Bernardi A, Bergamin LS, Cappellari AR, Campesato LF, Morrone FB, Campos MM, Calixto JB, Edelweiss MI, Wink MR, Sévigny J, Robson SC, Battastini AM. Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury. Purinergic Signal. 2012 Jun; 8(2):235-43. PMID: 22038661; PMCID: PMC3350588.
  136. Serra S, Horenstein AL, Vaisitti T, Brusa D, Rossi D, Laurenti L, D'Arena G, Coscia M, Tripodo C, Inghirami G, Robson SC, Gaidano G, Malavasi F, Deaglio S. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood. 2011 Dec 01; 118(23):6141-52. PMID: 21998208; PMCID: PMC3342854.
  137. Friedman DJ, Turka LA, Robson SC. There's a goat behind door number 3: from Monty Hall to medicine. J Clin Invest. 2011 Oct; 121(10):3819-21. PMID: 21968106; PMCID: PMC3195486.
  138. Cai M, Huttinger ZM, He H, Zhang W, Li F, Goodman LA, Wheeler DG, Druhan LJ, Zweier JL, Dwyer KM, He G, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury. J Mol Cell Cardiol. 2011 Dec; 51(6):927-35. PMID: 21939667; PMCID: PMC3245748.
  139. Sun X, Imai M, Nowak-Machen M, Guckelberger O, Enjyoji K, Wu Y, Khalpey Z, Berberat P, Munasinghe J, Robson SC. Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia. Purinergic Signal. 2011 Dec; 7(4):427-34. PMID: 21656186; PMCID: PMC3224647.
  140. Shalev I, Schmelzle M, Robson SC, Levy G. Making sense of regulatory T cell suppressive function. Semin Immunol. 2011 Aug; 23(4):282-92. PMID: 21592823; PMCID: PMC3158951.
  141. Eltzschig HK, Robson SC. NT5E mutations and arterial calcifications. N Engl J Med. 2011 Apr 21; 364(16):1577-8; author reply 1579-80. PMID: 21506753.
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  142. Yu W, Robson SC, Hill WG. Expression and distribution of ectonucleotidases in mouse urinary bladder. PLoS One. 2011 Apr 14; 6(4):e18704. PMID: 21533188; PMCID: PMC3077397.
  143. Künzli BM, Bernlochner MI, Rath S, Käser S, Csizmadia E, Enjyoji K, Cowan P, d'Apice A, Dwyer K, Rosenberg R, Perren A, Friess H, Maurer CA, Robson SC. Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer. Purinergic Signal. 2011 Jun; 7(2):231-41. PMID: 21484085; PMCID: PMC3146639.
  144. Cowan PJ, Robson SC, d'Apice AJ. Controlling coagulation dysregulation in xenotransplantation. Curr Opin Organ Transplant. 2011 Apr; 16(2):214-21. PMID: 21415824; PMCID: PMC3094512.
  145. Feng L, Sun X, Csizmadia E, Han L, Bian S, Murakami T, Wang X, Robson SC, Wu Y. Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate. Neoplasia. 2011 Mar; 13(3):206-16. PMID: 21390184; PMCID: PMC3050864.
  146. Schmelzle M, Cowan PJ, Robson SC. Which anti-platelet therapies might be beneficial in xenotransplantation? Xenotransplantation. 2011 Mar-Apr; 18(2):79-87. PMID: 21496115; PMCID: PMC3733105.
  147. Fisicaro N, Londrigan SL, Brady JL, Salvaris E, Nottle MB, O'Connell PJ, Robson SC, d'Apice AJ, Lew AM, Cowan PJ. Versatile co-expression of graft-protective proteins using 2A-linked cassettes. Xenotransplantation. 2011 Mar-Apr; 18(2):121-30. PMID: 21496119; PMCID: PMC3785253.
  148. Deaglio S, Robson SC. Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity. Adv Pharmacol. 2011; 61:301-32. PMID: 21586363.
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  149. Rajakumar SV, Lu B, Crikis S, Robson SC, d'Apice AJ, Cowan PJ, Dwyer KM. Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injury. Transplantation. 2010 Dec 27; 90(12):1260-4. PMID: 21063242.
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  150. Künzli BM, Berberat PO, Dwyer K, Deaglio S, Csizmadia E, Cowan P, d'Apice A, Moore G, Enjyoji K, Friess H, Robson SC. Variable impact of CD39 in experimental murine colitis. Dig Dis Sci. 2011 May; 56(5):1393-403. PMID: 20936356.
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  151. Sun X, Wu Y, Gao W, Enjyoji K, Csizmadia E, Müller CE, Murakami T, Robson SC. CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. Gastroenterology. 2010 Sep; 139(3):1030-40. PMID: 20546740; PMCID: PMC2930043.
  152. O'Keeffe MG, Thorne PR, Housley GD, Robson SC, Vlajkovic SM. Distribution of NTPDase5 and NTPDase6 and the regulation of P2Y receptor signalling in the rat cochlea. Purinergic Signal. 2010 Jun; 6(2):249-61. PMID: 20806016; PMCID: PMC2912994.
  153. Ho KJ, Do NL, Otu HH, Dib MJ, Ren X, Enjyoji K, Robson SC, Terwilliger EF, Karp SJ. Tob1 is a constitutively expressed repressor of liver regeneration. J Exp Med. 2010 Jun 07; 207(6):1197-208. PMID: 20513747; PMCID: PMC2882843.
  154. Beldi G, Banz Y, Kroemer A, Sun X, Wu Y, Graubardt N, Rellstab A, Nowak M, Enjyoji K, Li X, Junger WG, Candinas D, Robson SC. Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology. 2010 May; 51(5):1702-11. PMID: 20146261; PMCID: PMC2903010.
  155. Lévesque SA, Kukulski F, Enjyoji K, Robson SC, Sévigny J. NTPDase1 governs P2X7-dependent functions in murine macrophages. Eur J Immunol. 2010 May; 40(5):1473-85. PMID: 20201036; PMCID: PMC3045779.
  156. Schmelzle M, Schulte Esch J, Robson SC. Coagulation, platelet activation and thrombosis in xenotransplantation. Curr Opin Organ Transplant. 2010 Apr; 15(2):212-8. PMID: 20154620.
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  157. Robson SC, Schuppan D. Adenosine: tipping the balance towards hepatic steatosis and fibrosis. J Hepatol. 2010 Jun; 52(6):941-3. PMID: 20395005; PMCID: PMC2875264.
  158. O'Keeffe MG, Thorne PR, Housley GD, Robson SC, Vlajkovic SM. Developmentally regulated expression of ectonucleotidases NTPDase5 and NTPDase6 and UDP-responsive P2Y receptors in the rat cochlea. Histochem Cell Biol. 2010 Apr; 133(4):425-36. PMID: 20217113.
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  159. Hart ML, Gorzolla IC, Schittenhelm J, Robson SC, Eltzschig HK. SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J Immunol. 2010 Apr 01; 184(7):4017-24. PMID: 20207994; PMCID: PMC2846294.
  160. Schulte am Esch J, Akyildiz A, Tustas RY, Ganschow R, Schmelzle M, Krieg A, Robson SC, Topp SA, Rogiers X, Knoefel WT, Fischer L. ADP-dependent platelet function prior to and in the early course of pediatric liver transplantation and persisting thrombocytopenia are positively correlated with ischemia/reperfusion injury. Transpl Int. 2010 Jul; 23(7):745-52. PMID: 20136783.
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  161. Buffon A, Casali EA, Cardoso VV, Zerbini LF, Robson SC, Sarkis JJ, Wink MR. Differential expression of nucleotide pyrophosphatase/phosphodiesterases by Walker 256 mammary cancer cells in solid tumors and malignant ascites. Life Sci. 2010 Mar 13; 86(11-12):435-40. PMID: 20117116.
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  162. Friedman DJ, Künzli BM, A-Rahim YI, Sevigny J, Berberat PO, Enjyoji K, Csizmadia E, Friess H, Robson SC. From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16788-93. PMID: 19805374; PMCID: PMC2757811.
  163. Di Virgilio F, Boeynaems JM, Robson SC. Extracellular nucleotides as negative modulators of immunity. Curr Opin Pharmacol. 2009 Aug; 9(4):507-13. PMID: 19628431; PMCID: PMC4158611.
  164. Di Virgilio F, Robson SC. Identification of novel immunosuppressive pathways paves the way for drug discovery. Curr Opin Pharmacol. 2009 Aug; 9(4):445-6. PMID: 19625216; PMCID: PMC2756158.
  165. Sun X, Cárdenas A, Wu Y, Enjyoji K, Robson SC. Vascular stasis, intestinal hemorrhage, and heightened vascular permeability complicate acute portal hypertension in cd39-null mice. Am J Physiol Gastrointest Liver Physiol. 2009 Aug; 297(2):G306-11. PMID: 19520738; PMCID: PMC2724088.
  166. Braganhol E, Morrone FB, Bernardi A, Huppes D, Meurer L, Edelweiss MI, Lenz G, Wink MR, Robson SC, Battastini AM. Selective NTPDase2 expression modulates in vivo rat glioma growth. Cancer Sci. 2009 Aug; 100(8):1434-42. PMID: 19558578.
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  167. Sheth S, Bleibel W, Thukral C, A-Rahim Y, Beldi G, Csizmadia E, Robson SC. Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis. Purinergic Signal. 2009 Sep; 5(3):321-6. PMID: 19337853; PMCID: PMC2717313.
  168. Vlajkovic SM, Housley GD, Thorne PR, Gupta R, Enjyoji K, Cowan PJ, Charles Liberman M, Robson SC. Preservation of cochlear function in Cd39 deficient mice. Hear Res. 2009 Jul; 253(1-2):77-82. PMID: 19327391.
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  169. Behdad A, Sun X, Khalpey Z, Enjyoji K, Wink M, Wu Y, Usheva A, Robson SC. Vascular smooth muscle cell expression of ectonucleotidase CD39 (ENTPD1) is required for neointimal formation in mice. Purinergic Signal. 2009 Sep; 5(3):335-42. PMID: 19308674; PMCID: PMC2717316.
  170. Lu B, Rajakumar SV, Robson SC, Lee EK, Crikis S, d'Apice AJ, Cowan PJ, Dwyer KM. The impact of purinergic signaling on renal ischemia-reperfusion injury. Transplantation. 2008 Dec 27; 86(12):1707-12. PMID: 19104409.
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  171. Friedman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, Robson SC. Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease. Diabetes. 2009 Apr; 58(4):999-1006. PMID: 19095759; PMCID: PMC2661602.
  172. Sansom FM, Robson SC, Hartland EL. Possible effects of microbial ecto-nucleoside triphosphate diphosphohydrolases on host-pathogen interactions. Microbiol Mol Biol Rev. 2008 Dec; 72(4):765-81, Table of Contents. PMID: 19052327; PMCID: PMC2593569.
  173. Yano K, Okada Y, Beldi G, Shih SC, Bodyak N, Okada H, Kang PM, Luscinskas W, Robson SC, Carmeliet P, Karumanchi SA, Aird WC. Elevated levels of placental growth factor represent an adaptive host response in sepsis. J Exp Med. 2008 Oct 27; 205(11):2623-31. PMID: 18852292; PMCID: PMC2571936.
  174. Langer D, Hammer K, Koszalka P, Schrader J, Robson S, Zimmermann H. Distribution of ectonucleotidases in the rodent brain revisited. Cell Tissue Res. 2008 Nov; 334(2):199-217. PMID: 18843508.
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  175. Eltzschig HK, Köhler D, Eckle T, Kong T, Robson SC, Colgan SP. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood. 2009 Jan 01; 113(1):224-32. PMID: 18812468; PMCID: PMC2614635.
  176. Beldi G, Wu Y, Banz Y, Nowak M, Miller L, Enjyoji K, Haschemi A, Yegutkin GG, Candinas D, Exley M, Robson SC. Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis. Hepatology. 2008 Sep; 48(3):841-52. PMID: 18752325; PMCID: PMC2929828.
  177. Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17; 283(42):28480-6. PMID: 18713747; PMCID: PMC2568933.
  178. Beldi G, Wu Y, Sun X, Imai M, Enjyoji K, Csizmadia E, Candinas D, Erb L, Robson SC. Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration. Gastroenterology. 2008 Nov; 135(5):1751-60. PMID: 18804472; PMCID: PMC2900919.
  179. Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes. 2008 Sep; 57(9):2311-20. PMID: 18567823; PMCID: PMC2518482.
  180. Banz Y, Beldi G, Wu Y, Atkinson B, Usheva A, Robson SC. CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation. Br J Haematol. 2008 Aug; 142(4):627-37. PMID: 18537971; PMCID: PMC2886720.
  181. Shimizu A, Hisashi Y, Kuwaki K, Tseng YL, Dor FJ, Houser SL, Robson SC, Schuurman HJ, Cooper DK, Sachs DH, Yamada K, Colvin RB. Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol. 2008 Jun; 172(6):1471-81. PMID: 18467706; PMCID: PMC2408408.
  182. Lee KF, Salvaris EJ, Roussel JC, Robson SC, d'Apice AJ, Cowan PJ. Recombinant pig TFPI efficiently regulates human tissue factor pathways. Xenotransplantation. 2008 May-Jun; 15(3):191-7. PMID: 18611227; PMCID: PMC2517609.
  183. Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G. The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res. 2008 Apr 15; 68(8):2813-9. PMID: 18413749; PMCID: PMC2386271.
  184. Sansom FM, Riedmaier P, Newton HJ, Dunstone MA, Müller CE, Stephan H, Byres E, Beddoe T, Rossjohn J, Cowan PJ, d'Apice AJ, Robson SC, Hartland EL. Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence. J Biol Chem. 2008 May 09; 283(19):12909-18. PMID: 18337253; PMCID: PMC2442346.
  185. Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann J. Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F965-70. PMID: 18256308.
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  186. Färber K, Markworth S, Pannasch U, Nolte C, Prinz V, Kronenberg G, Gertz K, Endres M, Bechmann I, Enjyoji K, Robson SC, Kettenmann H. The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia. 2008 Feb; 56(3):331-41. PMID: 18098126.
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  187. Beldi G, Enjyoji K, Wu Y, Miller L, Banz Y, Sun X, Robson SC. The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism. Front Biosci. 2008 Jan 01; 13:2588-603. PMID: 17981736; PMCID: PMC2892180.
  188. Künzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D, Berberat PO, Friess H, Robson SC. Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice. Gastroenterology. 2008 Jan; 134(1):292-305. PMID: 18036594; PMCID: PMC2189558.
  189. Köhler D, Eckle T, Faigle M, Grenz A, Mittelbronn M, Laucher S, Hart ML, Robson SC, Müller CE, Eltzschig HK. CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation. 2007 Oct 16; 116(16):1784-94. PMID: 17909107.
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  190. Jackson SW, Hoshi T, Wu Y, Sun X, Enjyoji K, Cszimadia E, Sundberg C, Robson SC. Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice. Am J Pathol. 2007 Oct; 171(4):1395-404. PMID: 17823293; PMCID: PMC1988887.
  191. Iandiev I, Wurm A, Pannicke T, Wiedemann P, Reichenbach A, Robson SC, Zimmermann H, Bringmann A. Ectonucleotidases in Müller glial cells of the rodent retina: Involvement in inhibition of osmotic cell swelling. Purinergic Signal. 2007 Sep; 3(4):423-33. PMID: 18404455; PMCID: PMC2072913.
  192. Banz Y, Hess OM, Robson SC, Csizmadia E, Mettler D, Meier P, Haeberli A, Shaw S, Smith RA, Rieben R. Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1. Cardiovasc Res. 2007 Dec 01; 76(3):482-93. PMID: 17825275.
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  193. Sachs DH, Yamada K, Robson SC, Fishman JA, Shimizu A, Colvin RB, Sykes M. GalT-KO pigs: is the cup half empty or half full? Transplantation. 2007 Jul 15; 84(1):12-4. PMID: 17627230.
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  194. Buffon A, Wink MR, Ribeiro BV, Casali EA, Libermann TA, Zerbini LF, Robson SC, Sarkis JJ. NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor. Biochim Biophys Acta. 2007 Aug; 1770(8):1259-65. PMID: 17574764.
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  195. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65. PMID: 17502665; PMCID: PMC2118603.
  196. Friedman DJ, Rennke HG, Csizmadia E, Enjyoji K, Robson SC. The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy. Diabetes. 2007 Sep; 56(9):2371-9. PMID: 17473221.
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  197. Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE. Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 01; 178(9):5921-9. PMID: 17442976.
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  198. Grenz A, Zhang H, Hermes M, Eckle T, Klingel K, Huang DY, Müller CE, Robson SC, Osswald H, Eltzschig HK. Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 2007 Sep; 21(11):2863-73. PMID: 17442731.
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  199. Kruskal JB, Azouz A, Korideck H, El-Hallak M, Robson SC, Thomas P, Goldberg SN. Hepatic colorectal cancer metastases: imaging initial steps of formation in mice. Radiology. 2007 Jun; 243(3):703-11. PMID: 17431127.
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  200. Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC. CD39 and control of cellular immune responses. Purinergic Signal. 2007 Mar; 3(1-2):171-80. PMID: 18404431; PMCID: PMC2096766.
  201. Eltzschig HK, Eckle T, Mager A, Küper N, Karcher C, Weissmüller T, Boengler K, Schulz R, Robson SC, Colgan SP. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006 Nov 10; 99(10):1100-8. PMID: 17038639.
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  202. Robson S. The therapeutic potential of CD39: interview with Dr Simon Robson by Emma Quigley. Expert Opin Ther Targets. 2006 Oct; 10(5):649-52. PMID: 16981822.
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  203. Künzli BM, Berberat PO, Giese T, Csizmadia E, Kaczmarek E, Baker C, Halaceli I, Büchler MW, Friess H, Robson SC. Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G223-30. PMID: 16920697.
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  204. Dwyer KM, Mysore TB, Crikis S, Robson SC, Nandurkar H, Cowan PJ, D'Apice AJ. The transgenic expression of human CD39 on murine islets inhibits clotting of human blood. Transplantation. 2006 Aug 15; 82(3):428-32. PMID: 16906044.
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  205. Vlajkovic SM, Vinayagamoorthy A, Thorne PR, Robson SC, Wang CJ, Housley GD. Noise-induced up-regulation of NTPDase3 expression in the rat cochlea: Implications for auditory transmission and cochlear protection. Brain Res. 2006 Aug 09; 1104(1):55-63. PMID: 16815340.
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  206. Bleibel W, Thukral C, Robson SC. Overlap between systemic lupus erythematosus and nonalcoholic steatohepatitis. J Clin Gastroenterol. 2006 Jul; 40(6):561-2; author reply 562. PMID: 16825945.
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  207. Robson SC, Sévigny J, Zimmermann H. The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signal. 2006 Jun; 2(2):409-30. PMID: 18404480; PMCID: PMC2254478.
  208. Wu Y, Sun X, Kaczmarek E, Dwyer KM, Bianchi E, Usheva A, Robson SC. RanBPM associates with CD39 and modulates ecto-nucleotidase activity. Biochem J. 2006 May 15; 396(1):23-30. PMID: 16478441; PMCID: PMC1449986.
  209. Bilban M, Bach FH, Otterbein SL, Ifedigbo E, d'Avila JC, Esterbauer H, Chin BY, Usheva A, Robson SC, Wagner O, Otterbein LE. Carbon monoxide orchestrates a protective response through PPARgamma. Immunity. 2006 May; 24(5):601-10. PMID: 16713977.
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  210. Robson SC, Zimmermann H. Editorial. Purinergic Signal. 2006 Jun; 2(2):325-6. PMID: 18404471; PMCID: PMC2096526.
  211. Haller CA, Cui W, Wen J, Robson SC, Chaikof EL. Reconstitution of CD39 in liposomes amplifies nucleoside triphosphate diphosphohydrolase activity and restores thromboregulatory properties. J Vasc Surg. 2006 Apr; 43(4):816-23. PMID: 16616242.
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  212. Atkinson B, Dwyer K, Enjyoji K, Robson SC. Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):217-22. PMID: 16476557.
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  213. Mishra SK, Braun N, Shukla V, Füllgrabe M, Schomerus C, Korf HW, Gachet C, Ikehara Y, Sévigny J, Robson SC, Zimmermann H. Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Development. 2006 Feb; 133(4):675-84. PMID: 16436623.
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  214. Wink MR, Braganhol E, Tamajusuku AS, Lenz G, Zerbini LF, Libermann TA, Sévigny J, Battastini AM, Robson SC. Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes. Neuroscience. 2006; 138(2):421-32. PMID: 16414200.
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  215. Tseng YL, Kuwaki K, Dor FJ, Shimizu A, Houser S, Hisashi Y, Yamada K, Robson SC, Awwad M, Schuurman HJ, Sachs DH, Cooper DK. alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation. 2005 Nov 27; 80(10):1493-500. PMID: 16340796.
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  216. am Esch JS, Tustas RY, Robson SC, Hosch SB, Akyildiz A, Bröring DC, Fischer L, Knoefel WT, Rogiers X. Recipient levels and function of von Willebrand factor prior to liver transplantation and its consumption in the course of grafting correlate with hepatocellular damage and outcome. Transpl Int. 2005 Nov; 18(11):1258-65. PMID: 16221156.
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  217. Banz Y, Hess OM, Robson SC, Mettler D, Meier P, Haeberli A, Csizmadia E, Korchagina EY, Bovin NV, Rieben R. Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury. Eur Heart J. 2005 Nov; 26(21):2334-43. PMID: 16055495.
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  218. Shimizu A, Yamada K, Yamamoto S, Lavelle JM, Barth RN, Robson SC, Sachs DH, Colvin RB. Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. J Am Soc Nephrol. 2005 Sep; 16(9):2732-45. PMID: 16049072.
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  219. Shukla V, Zimmermann H, Wang L, Kettenmann H, Raab S, Hammer K, Sévigny J, Robson SC, Braun N. Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus. J Neurosci Res. 2005 Jun 01; 80(5):600-10. PMID: 15884037.
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  220. Kaczmarek E, Erb L, Koziak K, Jarzyna R, Wink MR, Guckelberger O, Blusztajn JK, Trinkaus-Randall V, Weisman GA, Robson SC. Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways. Thromb Haemost. 2005 Apr; 93(4):735-42. PMID: 15841322; PMCID: PMC2830093.
  221. Robson SC, Wu Y, Sun X, Knosalla C, Dwyer K, Enjyoji K. Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. Semin Thromb Hemost. 2005 Apr; 31(2):217-33. PMID: 15852225.
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  222. Berberat PO, A-Rahim YI, Yamashita K, Warny MM, Csizmadia E, Robson SC, Bach FH. Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis. Inflamm Bowel Dis. 2005 Apr; 11(4):350-9. PMID: 15803024.
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  223. Wang CJ, Vlajkovic SM, Housley GD, Braun N, Zimmermann H, Robson SC, Sévigny J, Soeller C, Thorne PR. C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation. Biochem J. 2005 Feb 01; 385(Pt 3):729-36. PMID: 15362980; PMCID: PMC1134748.
  224. Kishore BK, Isaac J, Fausther M, Tripp SR, Shi H, Gill PS, Braun N, Zimmermann H, Sévigny J, Robson SC. Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling. Am J Physiol Renal Physiol. 2005 May; 288(5):F1032-43. PMID: 15632415.
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  225. Schulte Am Esch J, Robson SC, Knoefel WT, Hosch SB, Rogiers X. O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors. Xenotransplantation. 2005 Jan; 12(1):30-7. PMID: 15598271.
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  226. Schulte am Esch J, Robson SC, Knoefel WT, Eisenberger CF, Peiper M, Rogiers X. Impact of O-linked glycosylation of the VWF-A1-domain flanking regions on platelet interaction. Br J Haematol. 2005 Jan; 128(1):82-90. PMID: 15606553.
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  227. Dor FJ, Kuwaki K, Tseng YL, Shimizu A, Houser SL, Yamada K, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Sachs DH, Schuurman HJ, Cooper DK. Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons. Transplant Proc. 2005 Jan-Feb; 37(1):489-90. PMID: 15808685.
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  228. Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, Lancos CJ, Prabharasuth DD, Cheng J, Moran K, Hisashi Y, Mueller N, Yamada K, Greenstein JL, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Schuurman HJ, Sachs DH, Cooper DK. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med. 2005 Jan; 11(1):29-31. PMID: 15619628.
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  229. Eltzschig HK, Thompson LF, Karhausen J, Cotta RJ, Ibla JC, Robson SC, Colgan SP. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood. 2004 Dec 15; 104(13):3986-92. PMID: 15319286.
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  230. Kittel A, Pelletier J, Bigonnesse F, Guckelberger O, Kordás K, Braun N, Robson SC, Sévigny J. Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary gland. J Histochem Cytochem. 2004 Jul; 52(7):861-71. PMID: 15208353.
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  231. Kittel A, Csapó ZS, Csizmadia E, Jackson SW, Robson SC. Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta. Eur J Histochem. 2004 Jul-Sep; 48(3):253-9. PMID: 15590415.
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  232. Gollackner B, Qawi I, Daniel S, Kaczmarek E, Cooper DK, Robson SC. Potential target molecules on pig kidneys recognized by naïve and elicited baboon antibodies. Xenotransplantation. 2004 Jul; 11(4):380-1. PMID: 15196135.
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  233. Gollackner B, Goh SK, Qawi I, Buhler L, Knosalla C, Daniel S, Kaczmarek E, Awwad M, Cooper DK, Robson SC. Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. Transplantation. 2004 Jun 15; 77(11):1735-41. PMID: 15201675.
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  234. Bigonnesse F, Lévesque SA, Kukulski F, Lecka J, Robson SC, Fernandes MJ, Sévigny J. Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8. Biochemistry. 2004 May 11; 43(18):5511-9. PMID: 15122917.
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  235. Dwyer KM, Robson SC, Nandurkar HH, Campbell DJ, Gock H, Murray-Segal LJ, Fisicaro N, Mysore TB, Kaczmarek E, Cowan PJ, d'Apice AJ. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest. 2004 May; 113(10):1440-6. PMID: 15146241; PMCID: PMC406523.
  236. Guckelberger O, Sun XF, Sévigny J, Imai M, Kaczmarek E, Enjyoji K, Kruskal JB, Robson SC. Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury. Thromb Haemost. 2004 Mar; 91(3):576-86. PMID: 14983235.
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  237. Dranoff JA, Ogawa M, Kruglov EA, Gaça MD, Sévigny J, Robson SC, Wells RG. Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G417-24. PMID: 14764443.
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  238. Braun N, Sévigny J, Robson SC, Hammer K, Hanani M, Zimmermann H. Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system. Glia. 2004 Jan 15; 45(2):124-32. PMID: 14730706.
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  239. Vlajkovic SM, Housley GD, Muñoz DJ, Robson SC, Sévigny J, Wang CJ, Thorne PR. Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea. Neuroscience. 2004; 126(3):763-73. PMID: 15183524.
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  240. Knosalla C, Giovino MA, Harper D, Kaczmarek E, Gollackner B, Cooper DK, Robson SC. Relative effects of GAL+ and GALlow/- porcine hematopoietic cells on primate platelet aggregation and endothelial cell activation: implications for the induction of mixed hematopoietic chimerism in the pig-to-primate model. Xenotransplantation. 2004 Jan; 11(1):72-7. PMID: 14962295.
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  241. Cardenas A, Robson S. Clinical differentiation between secondary and spontaneous bacterial peritonitis. J Clin Gastroenterol. 2004 Jan; 38(1):89. PMID: 14679339.
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  242. Knosalla C, Gollackner B, Bühler L, Mueller NJ, Houser S, Mauiyyedi S, Sachs DH, Robson SC, Fishman J, Schuurman HJ, Awwad M, Cooper DK. Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons. Am J Transplant. 2003 Dec; 3(12):1510-9. PMID: 14629281.
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  243. Eltzschig HK, Ibla JC, Furuta GT, Leonard MO, Jacobson KA, Enjyoji K, Robson SC, Colgan SP. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med. 2003 Sep 01; 198(5):783-96. PMID: 12939345; PMCID: PMC2194189.
  244. Teranishi K, Apitz-Castro R, Robson SC, Romano E, Cooper DK. Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene. Xenotransplantation. 2003 Jul; 10(4):374-9. PMID: 12795687.
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  245. Gollackner B, Mueller NJ, Houser S, Qawi I, Soizic D, Knosalla C, Buhler L, Dor FJ, Awwad M, Sachs DH, Cooper DK, Robson SC, Fishman JA. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. Transplantation. 2003 Jun 15; 75(11):1841-7. PMID: 12811243.
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  246. Pfeiffer S, Zorn GL, Zhang JP, Giorgio TD, Robson SC, Azimzadeh AM, Pierson RN. Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. Transplantation. 2003 Apr 15; 75(7):953-9. PMID: 12698079.
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  247. Braun N, Sévigny J, Mishra SK, Robson SC, Barth SW, Gerstberger R, Hammer K, Zimmermann H. Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain. Eur J Neurosci. 2003 Apr; 17(7):1355-64. PMID: 12713638.
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  248. Schulte am Esch J, Robson SC, Cruz MA. Platelet aggregation by membrane-expressed A1 domains of von Willebrand Factor is dependent on residues Asp 560 and Gly 561. Biochem Biophys Res Commun. 2003 Mar 21; 302(4):873-7. PMID: 12646253.
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  249. Dranoff JA, Kruglov EA, Robson SC, Braun N, Zimmermann H, Sévigny J. The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Hepatology. 2002 Nov; 36(5):1135-44. PMID: 12395323.
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  250. Vlajkovic SM, Thorne PR, Sévigny J, Robson SC, Housley GD. NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: implications for regulation of p2 receptor signaling. J Histochem Cytochem. 2002 Nov; 50(11):1435-42. PMID: 12417608.
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  251. Wang N, Lee JM, Tobiasch E, Csizmadia E, Smith NR, Gollackes B, Robson SC, Bach FH, Lin Y. Induction of xenograft accommodation by modulation of elicited antibody responses1 2. Transplantation. 2002 Aug 15; 74(3):334-45. PMID: 12177611.
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  252. Vlajkovic SM, Thorne PR, Sévigny J, Robson SC, Housley GD. Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea. Hear Res. 2002 Aug; 170(1-2):127-38. PMID: 12208547.
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  253. Cowan PJ, Aminian A, Barlow H, Brown AA, Dwyer K, Filshie RJ, Fisicaro N, Francis DM, Gock H, Goodman DJ, Katsoulis J, Robson SC, Salvaris E, Shinkel TA, Stewart AB, d'Apice AJ. Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation. Am J Transplant. 2002 Jul; 2(6):520-5. PMID: 12118895.
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  254. Appel JZ, Newman D, Awwad M, Kruger Gray HS, Down J, Cooper DK, Robson SC. Activation of human endothelial cells by mobilized porcine leukocytes in vitro: implications for mixed chimerism in xenotransplantation. Transplantation. 2002 Apr 27; 73(8):1302-9. PMID: 11981426.
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  255. Sévigny J, Sundberg C, Braun N, Guckelberger O, Csizmadia E, Qawi I, Imai M, Zimmermann H, Robson SC. Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation. Blood. 2002 Apr 15; 99(8):2801-9. PMID: 11929769.
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  256. Mizumoto N, Kumamoto T, Robson SC, Sévigny J, Matsue H, Enjyoji K, Takashima A. CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med. 2002 Apr; 8(4):358-65. PMID: 11927941.
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  257. Goepfert C, Sundberg C, Sévigny J, Enjyoji K, Hoshi T, Csizmadia E, Robson S. Disordered cellular migration and angiogenesis in cd39-null mice. Circulation. 2001 Dec 18; 104(25):3109-15. PMID: 11748109.
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  258. Bühler L, Yamada K, Kitamura H, Alwayn IP, Basker M, Appel JZ, Colvin RB, White-Scharf ME, Sachs DH, Robson SC, Awwad M, Cooper DK. Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. Transplantation. 2001 Dec 15; 72(11):1743-52. PMID: 11740383.
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  259. Appel JZ, Alwayn IP, Buhler L, DeAngelis HA, Robson SC, Cooper DK. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells. Transplantation. 2001 Oct 15; 72(7):1299-305. PMID: 11602859.
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  260. Appel JZ, Alwayn IP, Correa LE, Cooper DK, Robson SC. Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. II. The effects of cyclophosphamide on pig peripheral blood progenitor cell-induced aggregation. Transplantation. 2001 Oct 15; 72(7):1306-10. PMID: 11602860.
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  261. Gangadharan SP, Imai M, Rhynhart KK, Sévigny J, Robson SC, Conte MS. Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries. Surgery. 2001 Aug; 130(2):296-303. PMID: 11490363.
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  262. Robson SC. Thromboregulation by endothelial cells: significance for occlusive vascular diseases. Arterioscler Thromb Vasc Biol. 2001 Jul; 21(7):1251-2. PMID: 11451760.
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  263. Alwayn IP, Buhler L, Appel JZ, Goepfert C, Csizmadia E, Correa L, Harper D, Kitamura H, Down J, Awwad M, Sackstein R, Cooper DK, Robson SC. Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation. Transplantation. 2001 Jun 15; 71(11):1601-9. PMID: 11435972.
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  264. Qawi I, Robson SC. New developments in anti-platelet therapies: potential use of CD39/vascular ATP diphosphohydrolase in thrombotic disorders. Curr Drug Targets. 2001 Jun; 2(2):213-4. PMID: 11469720.
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  265. Bühler L, Goepfert C, Kitamura H, Basker M, Gojo S, Alwayn IP, Chang Q, Down JD, Tsai H, Wise R, Sachs DH, Cooper DK, Robson SC, Sackstein R. Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy. Bone Marrow Transplant. 2001 Jun; 27(12):1227-36. PMID: 11548840.
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  266. Warny M, Aboudola S, Robson SC, Sévigny J, Communi D, Soltoff SP, Kelly CP. P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem. 2001 Jul 13; 276(28):26051-6. PMID: 11349132.
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  267. Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, Choi AM, Bach FH, Soares MP. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol. 2001 Mar 15; 166(6):4185-94. PMID: 11238670.
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  268. Buhler L, Alwayn IP, Appel JZ, Robson SC, Cooper DK. Anti-CD154 monoclonal antibody and thromboembolism. Transplantation. 2001 Feb 15; 71(3):491. PMID: 11233918.
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  269. Wang N, Lee JM, Soares MP, Csizmadia E, Robson SC, Smith N, Bach FH, Lin Y. Long-term survival of hamster hearts in presensitized rats. Transplant Proc. 2001 Feb-Mar; 33(1-2):747-8. PMID: 11267051.
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  270. Sachs DH, Sykes M, Robson SC, Cooper DK. Xenotransplantation. Adv Immunol. 2001; 79:129-223. PMID: 11680007.
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  271. Abraham EH, Sterling KM, Kim RJ, Salikhova AY, Huffman HB, Crockett MA, Johnston N, Parker HW, Boyle WE, Hartov A, Demidenko E, Efird J, Kahn J, Grubman SA, Jefferson DM, Robson SC, Thakar JH, Lorico A, Rappa G, Sartorelli AC, Okunieff P. Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis. Blood Cells Mol Dis. 2001 Jan-Feb; 27(1):165-80. PMID: 11358378.
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  272. Heine P, Braun N, Sévigny J, Robson SC, Servos J, Zimmermann H. The C-terminal cysteine-rich region dictates specific catalytic properties in chimeras of the ectonucleotidases NTPDase1 and NTPDase2. Eur J Biochem. 2001 Jan; 268(2):364-73. PMID: 11168371.
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  273. Braun N, Sévigny J, Robson SC, Enjyoji K, Guckelberger O, Hammer K, Di Virgilio F, Zimmermann H. Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain. Eur J Neurosci. 2000 Dec; 12(12):4357-66. PMID: 11122346.
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  274. Bühler L, Basker M, Alwayn IP, Goepfert C, Kitamura H, Kawai T, Gojo S, Kozlowski T, Ierino FL, Awwad M, Sachs DH, Sackstein R, Robson SC, Cooper DK. Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation. 2000 Nov 15; 70(9):1323-31. PMID: 11087147.
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  275. Alwayn IP, Appel JZ, Goepfert C, Buhler L, Cooper DK, Robson SC. Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation. Xenotransplantation. 2000 Nov; 7(4):247-57. PMID: 11081759.
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  276. Qawi I, Robson SC. New developments in anti-platelet therapies: potential use of CD39/vascular ATP diphosphohydrolase in thrombotic disorders. Curr Drug Targets. 2000 Nov; 1(3):285-96. PMID: 11465076.
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  277. Imai M, Takigami K, Guckelberger O, Kaczmarek E, Csizmadia E, Bach FH, Robson SC. Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival. Transplantation. 2000 Sep 27; 70(6):864-70. PMID: 11014639.
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  278. Imai M, Takigami K, Guckelberger O, Lin Y, Sevigny J, Kaczmarek E, Goepfert C, Enjyoji K, Bach FH, Rosenberg RD, Robson SC. CD39/vascular ATP diphosphohydrolase modulates xenograft survival. Transplant Proc. 2000 Aug; 32(5):969. PMID: 10936301.
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  279. Robson SC, Cooper DK, d'Apice AJ. Disordered regulation of coagulation and platelet activation in xenotransplantation. Xenotransplantation. 2000 Aug; 7(3):166-76. PMID: 11021661.
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  280. Alwayn IP, Buhler L, Basker M, Goepfert C, Kawai T, Kozlowski T, Ierino F, Sachs DH, Sackstein R, Robson SC, Cooper DK. Coagulation/thrombotic disorders associated with organ and cell xenotransplantation. Transplant Proc. 2000 Aug; 32(5):1099. PMID: 10936376.
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  281. Gopfert C, Buhler L, Wise R, Basker M, Gojo S, Imai M, Alwayn I, Sachs DH, Sackstein R, Cooper DK, Robson SC. Von willebrand factor concentration, multimeric patterns, and cleaving protease activity in baboons undergoing xenogeneic peripheral blood stem cell transplantation. Transplant Proc. 2000 Aug; 32(5):990. PMID: 10936315.
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  282. Goepfert C, Imai M, Brouard S, Csizmadia E, Kaczmarek E, Robson SC. CD39 modulates endothelial cell activation and apoptosis. Mol Med. 2000 Jul; 6(7):591-603. PMID: 10997340; PMCID: PMC1949966.
  283. Lin Y, Soares MP, Sato K, Csizmadia E, Robson SC, Smith N, Bach FH. Long-term survival of hamster hearts in presensitized rats. J Immunol. 2000 May 01; 164(9):4883-92. PMID: 10779798.
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  284. Imai M, Goepfert C, Kaczmarek E, Robson SC. CD39 modulates IL-1 release from activated endothelial cells. Biochem Biophys Res Commun. 2000 Apr 02; 270(1):272-8. PMID: 10733939.
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  285. Sévigny J, Robson SC, Waelkens E, Csizmadia E, Smith RN, Lemmens R. Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase. J Biol Chem. 2000 Feb 25; 275(8):5640-7. PMID: 10681547.
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  286. Koziak K, Kaczmarek E, Kittel A, Sévigny J, Blusztajn JK, Schulte Am Esch J, Imai M, Guckelberger O, Goepfert C, Qawi I, Robson SC. Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae. J Biol Chem. 2000 Jan 21; 275(3):2057-62. PMID: 10636909.
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  287. Koziak K, Sévigny J, Robson SC, Siegel JB, Kaczmarek E. Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes. Thromb Haemost. 1999 Nov; 82(5):1538-44. PMID: 10595651.
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  288. Imai M, Takigami K, Guckelberger O, Enjyoji K, Smith RN, Lin Y, Csizmadia E, Sévigny J, Rosenberg RD, Bach FH, Robson SC. Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection. Mol Med. 1999 Nov; 5(11):743-52. PMID: 10656876; PMCID: PMC2230486.
  289. Palmetshofer A, Robson SC, Nehls V. Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells. Thromb Haemost. 1999 Nov; 82(5):1532-7. PMID: 10595650.
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  290. Imai M, Kaczmarek E, Koziak K, Sévigny J, Goepfert C, Guckelberger O, Csizmadia E, Schulte Am Esch J, Robson SC. Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells. Biochemistry. 1999 Oct 12; 38(41):13473-9. PMID: 10521254.
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  291. Kittel A, Kaczmarek E, Sevigny J, Lengyel K, Csizmadia E, Robson SC. CD39 as a caveolar-associated ectonucleotidase. Biochem Biophys Res Commun. 1999 Sep 07; 262(3):596-9. PMID: 10471369.
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  292. Enjyoji K, Sévigny J, Lin Y, Frenette PS, Christie PD, Esch JS, Imai M, Edelberg JM, Rayburn H, Lech M, Beeler DL, Csizmadia E, Wagner DD, Robson SC, Rosenberg RD. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med. 1999 Sep; 5(9):1010-7. PMID: 10470077.
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  293. Robson SC, Schulte am Esch J, Bach FH. Factors in xenograft rejection. Ann N Y Acad Sci. 1999 Jun 18; 875:261-76. PMID: 10415573.
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  294. Schulte am Esch J, Sévigny J, Kaczmarek E, Siegel JB, Imai M, Koziak K, Beaudoin AR, Robson SC. Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity. Biochemistry. 1999 Feb 23; 38(8):2248-58. PMID: 10029517.
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  295. Kozlowski T, Shimizu A, Lambrigts D, Yamada K, Fuchimoto Y, Glaser R, Monroy R, Xu Y, Awwad M, Colvin RB, Cosimi AB, Robson SC, Fishman J, Spitzer TR, Cooper DK, Sachs DH. Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption. Transplantation. 1999 Jan 15; 67(1):18-30. PMID: 9921791.
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  296. Ierino FL, Kozlowski T, Siegel JB, Shimizu A, Colvin RB, Banerjee PT, Cooper DK, Cosimi AB, Bach FH, Sachs DH, Robson SC. Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts. Transplantation. 1998 Dec 15; 66(11):1439-50. PMID: 9869084.
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  297. von Albertini M, Palmetshofer A, Kaczmarek E, Koziak K, Stroka D, Grey ST, Stuhlmeier KM, Robson SC. Extracellular ATP and ADP activate transcription factor NF-kappa B and induce endothelial cell apoptosis. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):822-9. PMID: 9704012.
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  298. Kopp CW, Grey ST, Siegel JB, McShea A, Vetr H, Wrighton CJ, Schulte am Esch J, Bach FH, Robson SC. Expression of human thrombomodulin cofactor activity in porcine endothelial cells. Transplantation. 1998 Jul 27; 66(2):244-51. PMID: 9701273.
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  299. Palmetshofer A, Galili U, Dalmasso AP, Robson SC, Bach FH. Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells: type II activation. Transplantation. 1998 Apr 15; 65(7):971-8. PMID: 9565103.
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  300. Palmetshofer A, Galili U, Dalmasso AP, Robson SC, Bach FH. Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells: type I activation. Transplantation. 1998 Mar 27; 65(6):844-53. PMID: 9539098.
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  301. Kopp CW, Robson SC, Siegel JB, Anrather J, Winkler H, Grey S, Kaczmarek E, Bach FH, Geczy CL. Regulation of monocyte tissue factor activity by allogeneic and xenogeneic endothelial cells. Thromb Haemost. 1998 Mar; 79(3):529-38. PMID: 9531035.
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  302. Palmetshofer A, Robson SC, Bach FH. Tyrosine phosphorylation following lectin mediated endothelial cell stimulation. Xenotransplantation. 1998 Feb; 5(1):61-6. PMID: 9507735.
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  303. Bach FH, Fishman JA, Daniels N, Proimos J, Anderson B, Carpenter CB, Forrow L, Robson SC, Fineberg HV. Uncertainty in xenotransplantation: individual benefit versus collective risk. Nat Med. 1998 Feb; 4(2):141-4. PMID: 9461178.
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  304. Anrather D, Millan MT, Palmetshofer A, Robson SC, Geczy C, Ritchie AJ, Bach FH, Ewenstein BM. Thrombin activates nuclear factor-kappaB and potentiates endothelial cell activation by TNF. J Immunol. 1997 Dec 01; 159(11):5620-8. PMID: 9548505.
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  305. Schulte am Esch J, Cruz MA, Siegel JB, Anrather J, Robson SC. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. Blood. 1997 Dec 01; 90(11):4425-37. PMID: 9373253.
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  306. Siegel JB, Grey ST, Lesnikoski BA, Kopp CW, Soares M, Schulte am Esch J, Bach FH, Robson SC. Xenogeneic endothelial cells activate human prothrombin. Transplantation. 1997 Sep 27; 64(6):888-96. PMID: 9326416.
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  307. Bach FH, Ferran C, Soares M, Wrighton CJ, Anrather J, Winkler H, Robson SC, Hancock WW. Modification of vascular responses in xenotransplantation: inflammation and apoptosis. Nat Med. 1997 Sep; 3(9):944-8. PMID: 9288711.
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  308. Kopp CW, Siegel JB, Hancock WW, Anrather J, Winkler H, Geczy CL, Kaczmarek E, Bach FH, Robson SC. Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation. 1997 Mar 15; 63(5):749-58. PMID: 9075849.
    View in: PubMed
  309. von Albertini MA, Stroka DM, Brostjan C, Stuhlmeier KM, Bach FH, Robson SC. Adenosine nucleotides induce E-selectin expression in porcine endothelial cells. Transplant Proc. 1997 Feb-Mar; 29(1-2):1062. PMID: 9123199.
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  310. Koyamada N, Miyatake T, Candinas D, Hechenleitner P, Siegel J, Hancock WW, Bach FH, Robson SC. Apyrase administration prolongs discordant xenograft survival. Transplantation. 1996 Dec 27; 62(12):1739-43. PMID: 8990354.
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  311. Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J Biol Chem. 1996 Dec 20; 271(51):33116-22. PMID: 8955160.
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  312. Candinas D, Lesnikoski BA, Robson SC, Miyatake T, Scesney SM, Marsh HC, Ryan US, Dalmasso AP, Hancock WW, Bach FH. Effect of repetitive high-dose treatment with soluble complement receptor type 1 and cobra venom factor on discordant xenograft survival. Transplantation. 1996 Aug 15; 62(3):336-42. PMID: 8779679.
    View in: PubMed
  313. Bach FH, Winkler H, Ferran C, Hancock WW, Robson SC. Delayed xenograft rejection. Immunol Today. 1996 Aug; 17(8):379-84. PMID: 8783499.
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  314. Candinas D, Lesnikoski BA, Hancock WW, Otsu I, Koyamada N, Dalmasso AP, Robson SC, Bach FH. Inhibition of platelet integrin GPIIbIIIa prolongs survival of discordant cardiac xenografts. Transplantation. 1996 Jul 15; 62(1):1-5. PMID: 8693522.
    View in: PubMed
  315. Robson SC, Candinas D, Winkler H, Kopp C, Hancock WW, Bach FH. Immunobiology of discordant xenograft rejection and potential therapeutic modalities. Transplant Proc. 1996 Jun; 28(3):1154-5. PMID: 8658607.
    View in: PubMed
  316. Lesnikoski BA, Candinas D, Hancock WW, Otsu I, Siegel J, Bach FH, Robson SC. Inhibition of platelet GPIIbIIIa prolongs survival of discordant cardiac xenografts. Transplant Proc. 1996 Apr; 28(2):703. PMID: 8623355.
    View in: PubMed
  317. Robson SC, Candinas D, Siegel JB, Kopp C, Millan M, Hancock WW, Bach FH. Potential mechanism of abnormal thromboregulation in xenograft rejection: loss of ecto-ATPases upon endothelial cell activation. Transplant Proc. 1996 Apr; 28(2):536. PMID: 8623252.
    View in: PubMed
  318. Candinas D, Lesnikoski BA, Robson SC, Scesney SM, Otsu I, Myiatake T, Marsh HC, Ryan US, Hancock WW, Bach FH. Soluble complement receptor type 1 and cobra venom factor in discordant xenotransplantation. Transplant Proc. 1996 Apr; 28(2):581. PMID: 8623282.
    View in: PubMed
  319. Robson SC, Young VK, Cook NS, Metternich R, Kasper-Konig W, Lesnikoski BA, Pierson RN, Hancock WW, Candinas D, White DJ, Bach FH. Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation. 1996 Mar 27; 61(6):862-8. PMID: 8623150.
    View in: PubMed
  320. Robson SC, Siegel JB, Kirsch RE. Inhibition of T cell mitogenesis by a novel anti-CD45R monoclonal antibody. Immunol Cell Biol. 1996 Feb; 74(1):65-71. PMID: 8934656.
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  321. Bach FH, Robson SC, Wrighton CJ, Stuhlmeier K, Ferran C, Winkler H. Genetic engineering of endothelial cells to ameliorate xenograft rejection. Clin Transplant. 1996 Feb; 10(1 Pt 2):124-7. PMID: 8680048.
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  322. Bach FH, Winkler H, Wrighton CJ, Robson SC, Stuhlmeier K, Ferran C. Xenotransplantation: a possible solution to the shortage of donor organs. Transplant Proc. 1996 Feb; 28(1):416-7. PMID: 8644298.
    View in: PubMed
  323. Bach FH, Robson SC, Winkler H, Ferran C, Stuhlmeier KM, Wrighton CJ, Hancock WW. Barriers to xenotransplantation. Nat Med. 1995 Sep; 1(9):869-73. PMID: 7585204.
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  324. Robson SC, Candinas D, Hancock WW, Wrighton C, Winkler H, Bach FH. Role of endothelial cells in transplantation. Int Arch Allergy Immunol. 1995 Apr; 106(4):305-22. PMID: 7719148.
    View in: PubMed
  325. Bach FH, Robson SC, Ferran C, Millan M, Anrather J, Kopp C, Lesnikoski B, Goodman DJ, Hancock WW, Wrighton C, et al. Xenotransplantation: endothelial cell activation and beyond. Transplant Proc. 1995 Feb; 27(1):77-9. PMID: 7879178.
    View in: PubMed
  326. Bach FH, Robson SC, Ferran C, Winkler H, Millan MT, Stuhlmeier KM, Vanhove B, Blakely ML, van der Werf WJ, Hofer E, et al. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev. 1994 Oct; 141:5-30. PMID: 7868157.
    View in: PubMed
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