Harvard Catalyst Profiles

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Michael N. Starnbach, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21AI178272 (STARNBACH, MICHAEL N) Jun 6, 2023 - May 31, 2025
    NIH
    Identifying Chlamydia trachomatis factors that mediate PD-L1 upregulation
    Role: Principal Investigator
  2. U19AI113187 (WHEELER, COSETTE MARIE) Jul 1, 2014 - Jun 30, 2019
    NIH/NIAID
    Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Inf
    Role: Co-Principal Investigator
  3. R21AI097691 (STARNBACH, MICHAEL N) Jul 1, 2012 - Jun 30, 2015
    NIH
    Interferon gamma-mediated restriction of Shigella flexneri replication
    Role: Principal Investigator
  4. R21AI096101 (STARNBACH, MICHAEL N) Jun 1, 2011 - May 31, 2013
    NIH
    Alteration of host protein stability by Legionella
    Role: Principal Investigator
  5. R13AI084190 (STARNBACH, MICHAEL N) Jul 13, 2009 - Jun 30, 2010
    NIH
    2009 Gordon Conference on Microbial Adhesion and Signal Transduction
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 87 total Publications Show all
  1. Mao H, Dumas EK, Starnbach MN. Chlamydia trachomatis impairs T cell priming by inducing dendritic cell death. Infect Immun. 2025 Jan 08; e0040224. PMID: 39772728.
    Citations:
    Fields: AllAllergy and ImmunologyComCommunicable Diseases
  2. Olivas J, Nogueira C, Helble J, Starnbach MN. Cytotoxic CD4+ T Cells Are Induced during Infection with Chlamydia trachomatis. J Immunol. 2024 Aug 01; 213(3):328-338. PMID: 38905023; PMCID: PMC11279525.
    Citations:
    Fields: AllAllergy and ImmunologyTranslation:HumansAnimalsCells
  3. Helble JD, McCarthy JE, Sawden M, Starnbach MN, Hu LT. The PD-1/PD-L1 pathway is induced during Borrelia burgdorferi infection and inhibits T cell joint infiltration without compromising bacterial clearance. PLoS Pathog. 2022 10; 18(10):e1010903. PMID: 36265003; PMCID: PMC9624412.
    Citations: 7
    Fields: MicMicrobiologyTranslation:AnimalsCells
  4. Helble JD, Starnbach MN. T cell responses to Chlamydia. Pathog Dis. 2021 03 31; 79(4). PMID: 33693620; PMCID: PMC8012111.
    Citations: 12
    Fields: ComCommunicable DiseasesMicMicrobiologyTranslation:HumansAnimalsCells
  5. Laborde RJ, Ishimura ME, Abreu-Butin L, Nogueira CV, Grubaugh D, Cruz-Leal Y, Luzardo MC, Fernández A, Mesa C, Pazos F, Álvarez C, Alonso ME, Starnbach MN, Higgins DE, Fernández LE, Longo-Maugéri IM, Lanio ME. Sticholysins, pore-forming proteins from a marine anemone can induce maturation of dendritic cells through a TLR4 dependent-pathway. Mol Immunol. 2021 03; 131:144-154. PMID: 33422341.
    Citations: 3
    Fields: AllAllergy and ImmunologyMolMolecular BiologyTranslation:AnimalsCells
  6. Helble JD, Mann AO, Starnbach MN. Antigen-specific memory and naïve CD4+ T cells following secondary Chlamydia trachomatis infection. PLoS One. 2020; 15(10):e0240670. PMID: 33091023; PMCID: PMC7580951.
    Citations: 2
    Fields: MedMedicine (General)SciScienceTranslation:AnimalsCells
  7. Helble JD, Gonzalez RJ, von Andrian UH, Starnbach MN. Gamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract. mBio. 2020 03 17; 11(2). PMID: 32184237; PMCID: PMC7078466.
    Citations: 14
    Fields: MicMicrobiologyTranslation:AnimalsCells
  8. Starnbach MN. The well-evolved pathogen. Curr Opin Microbiol. 2020 04; 54:33-36. PMID: 32018150.
    Citations: 1
    Fields: MicMicrobiologyTranslation:HumansAnimalsCells
  9. Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22. PMID: 31813624; PMCID: PMC6954329.
    Citations: 146
    Fields: CelCell BiologyTranslation:AnimalsCells
  10. Helble JD, Reinhold-Larsson NV, Starnbach MN. Early Colonization of the Upper Genital Tract by Chlamydia muridarum Is Associated with Enhanced Inflammation Later in Infection. Infect Immun. 2019 09; 87(9). PMID: 31285254; PMCID: PMC6704611.
    Citations: 3
    Fields: AllAllergy and ImmunologyComCommunicable DiseasesTranslation:AnimalsCells
  11. Helble JD, Starnbach MN. A Chlamydia trachomatis Strain Expressing Ovalbumin Stimulates an Antigen-Specific CD4+ T Cell Response in Mice. Infect Immun. 2019 07; 87(7). PMID: 30988057; PMCID: PMC6589065.
    Citations: 3
    Fields: AllAllergy and ImmunologyComCommunicable DiseasesTranslation:AnimalsCells
  12. Park JS, Helble JD, Lazarus JE, Yang G, Blondel CJ, Doench JG, Starnbach MN, Waldor MK. A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion. iScience. 2019 Jan 25; 11:71-84. PMID: 30590252; PMCID: PMC6308251.
    Citations: 12
  13. Cruz-Leal Y, Grubaugh D, Nogueira CV, Lopetegui-González I, Del Valle A, Escalona F, Laborde RJ, Alvarez C, Fernández LE, Starnbach MN, Higgins DE, Lanio ME. The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes. Front Immunol. 2018; 9:2473. PMID: 30455685; PMCID: PMC6230584.
    Citations: 6
    Fields: AllAllergy and ImmunologyTranslation:AnimalsCells
  14. Starnbach MN. Action Needed on Chlamydia Vaccines. Trends Microbiol. 2018 08; 26(8):639-640. PMID: 29858127.
    Citations: 11
    Fields: MicMicrobiologyTranslation:HumansCellsPHPublic Health
  15. Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Viehmann Milam A, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW. LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. J Biol Chem. 2018 04 20; 293(16):6022-6038. PMID: 29496999; PMCID: PMC5912457.
    Citations: 8
    Fields: BioBiochemistryTranslation:Animals
  16. Lijek RS, Helble JD, Olive AJ, Seiger KW, Starnbach MN. Pathology after Chlamydia trachomatis infection is driven by nonprotective immune cells that are distinct from protective populations. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2216-2221. PMID: 29440378; PMCID: PMC5834673.
    Citations: 31
    Fields: SciScienceTranslation:AnimalsCells
  17. Ramírez-Peinado S, Ignashkova TI, van Raam BJ, Baumann J, Sennott EL, Gendarme M, Lindemann RK, Starnbach MN, Reiling JH. TRAPPC13 modulates autophagy and the response to Golgi stress. J Cell Sci. 2017 Jul 15; 130(14):2251-2265. PMID: 28536105; PMCID: PMC6518214.
    Citations: 22
    Fields: CelCell BiologyTranslation:HumansCells
  18. Laborde RJ, Sanchez-Ferras O, Luzardo MC, Cruz-Leal Y, Fernández A, Mesa C, Oliver L, Canet L, Abreu-Butin L, Nogueira CV, Tejuca M, Pazos F, Álvarez C, Alonso ME, Longo-Maugéri IM, Starnbach MN, Higgins DE, Fernández LE, Lanio ME. Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response. J Immunol. 2017 04 01; 198(7):2772-2784. PMID: 28258198; PMCID: PMC5686032.
    Citations: 9
    Fields: AllAllergy and ImmunologyTranslation:AnimalsCells
  19. Zhang X, Starnbach MN. An Excess of the Proinflammatory Cytokines IFN-? and IL-12 Impairs the Development of the Memory CD8+ T Cell Response to Chlamydia trachomatis. J Immunol. 2015 Aug 15; 195(4):1665-75. PMID: 26179901; PMCID: PMC4530050.
    Citations: 10
    Fields: AllAllergy and ImmunologyTranslation:AnimalsCells
  20. Mirrashidi KM, Elwell CA, Verschueren E, Johnson JR, Frando A, Von Dollen J, Rosenberg O, Gulbahce N, Jang G, Johnson T, Jäger S, Gopalakrishnan AM, Sherry J, Dunn JD, Olive A, Penn B, Shales M, Cox JS, Starnbach MN, Derre I, Valdivia R, Krogan NJ, Engel J. Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. Cell Host Microbe. 2015 Jul 08; 18(1):109-21. PMID: 26118995; PMCID: PMC4540348.
    Citations: 117
    Fields: MicMicrobiologyTranslation:HumansCells
  21. Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015 Jun 19; 348(6241):aaa8205. PMID: 26089520; PMCID: PMC4605428.
    Citations: 211
    Fields: SciScienceTranslation:AnimalsCellsPHPublic Health
  22. López-Abarrategui C, McBeth C, Mandal SM, Sun ZJ, Heffron G, Alba-Menéndez A, Migliolo L, Reyes-Acosta O, García-Villarino M, Nolasco DO, Falcão R, Cherobim MD, Dias SC, Brandt W, Wessjohann L, Starnbach M, Franco OL, Otero-González AJ. Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae). FASEB J. 2015 Aug; 29(8):3315-25. PMID: 25921828; PMCID: PMC4763977.
    Citations: 20
    Fields: BioBiologyPhyPhysiologyTranslation:AnimalsCells
  23. Nogueira CV, Zhang X, Giovannone N, Sennott EL, Starnbach MN. Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosae. J Immunol. 2015 Mar 01; 194(5):2319-29. PMID: 25637024; PMCID: PMC4340718.
    Citations: 22
    Fields: AllAllergy and ImmunologyTranslation:HumansAnimalsCellsPHPublic Health
  24. Davila SJ, Olive AJ, Starnbach MN. Integrin a4ß1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection. J Immunol. 2014 May 01; 192(9):4284-93. PMID: 24659687; PMCID: PMC3995848.
    Citations: 19
    Fields: AllAllergy and ImmunologyTranslation:AnimalsCells
  25. Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. Cell Host Microbe. 2014 Jan 15; 15(1):113-24. PMID: 24439903.
    Citations: 23
    Fields: MicMicrobiologyTranslation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.