Harvard Catalyst Profiles

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Khalid Shah, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS121096 (SHAH, KHALID A) Apr 15, 2021 - Mar 31, 2026
    Gene Edited and Engineered Tumor Cell Therapeutics for Cancer
    Role: Principal Investigator
  2. R01NS107857 (SHAH, KHALID A) Mar 1, 2019 - Feb 29, 2024
    Engineered and Encapsulated Stem Cells for Resected Brain Tumors
    Role: Principal Investigator
  3. R01CA201148 (SHAH, KHALID A) Jul 1, 2016 - Jul 31, 2021
    Fate and efficacy of targeted therapies for metastatic tumors
    Role: Principal Investigator
  4. R01CA204720 (SHAH, KHALID A) Mar 1, 2016 - Feb 28, 2021
    In vivo imaging of the stem cell loaded oncolytic viruses for cancer therapy
    Role: Principal Investigator
  5. R01CA173077 (SHAH, KHALID A) Jan 1, 2013 - Dec 31, 2017
    In vivo imaging of encapsulated stem cells in mouse models of tumor resection
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu L, Shah K. The Potential of the Gut Microbiome to Reshape the Cancer Therapy Paradigm: A Review. JAMA Oncol. 2022 07 01; 8(7):1059-1067. PMID: 35482355.
    Citations:    Fields:    Translation:Humans
  2. Bhere D, Choi SH, van de Donk P, Hope D, Gortzak K, Kunnummal A, Khalsa J, Revai Lechtich E, Reinshagen C, Leon V, Nissar N, Bi WL, Feng C, Li H, Zhang YS, Liang SH, Vasdev N, Essayed W, Quevedo PV, Golby A, Banouni N, Palagina A, Abdi R, Fury B, Smirnakis S, Lowe A, Reeve B, Hiller A, Chiocca EA, Prestwich G, Wakimoto H, Bauer G, Shah K. Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nat Commun. 2022 05 19; 13(1):2810. PMID: 35589724; PMCID: PMC9120173.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Liu L, Huh JR, Shah K. Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS. EBioMedicine. 2022 Mar; 77:103908. PMID: 35255456; PMCID: PMC8897630.
    Citations: 2     Fields:    Translation:HumansCells
  4. Karakas N, Üçüncüoglu S, Uludag D, Karaoglan BS, Shah K, Öztürk G. Mesenchymal Stem Cell-Based COVID-19 Therapy: Bioengineering Perspectives. Cells. 2022 01 29; 11(3). PMID: 35159275; PMCID: PMC8834073.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  5. Balatsoukas A, Rossignoli F, Shah K. NK cells in the brain: implications for brain tumor development and therapy. Trends Mol Med. 2022 03; 28(3):194-209. PMID: 35078713; PMCID: PMC8882142.
    Citations:    Fields:    Translation:HumansCells
  6. Arghiani N, Shah K. Modulating microRNAs in cancer: Next-generation therapies. Cancer Biol Med. 2021 Dec 01. PMID: 34846108; PMCID: PMC8958885.
    Citations: 1     Fields:    
  7. Ishii Y, Kolluri KK, Pennycuick A, Zhang X, Nigro E, Alrifai D, Borg E, Falzon M, Shah K, Kumar N, Janes SM. BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma. J Biol Chem. 2021 11; 297(5):101223. PMID: 34597666; PMCID: PMC8545693.
    Citations: 2     Fields:    Translation:HumansCells
  8. Tawfik EA, Aldrak NA, Albrahim SH, Alzahrani DA, Alfassam HA, Alkoblan SM, Almalik AM, Chen KS, Abou-Khalil R, Shah K, Zaidan NM. Immunotherapy in hematological malignancies: recent advances and open questions. Immunotherapy. 2021 10; 13(14):1215-1229. PMID: 34498496.
    Citations: 2     Fields:    Translation:Humans
  9. Aldrak N, Alsaab S, Algethami A, Bhere D, Wakimoto H, Shah K, Alomary MN, Zaidan N. Oncolytic Herpes Simplex Virus-Based Therapies for Cancer. Cells. 2021 06 18; 10(6). PMID: 34207386.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Karakas N, Stuckey D, Revai-Lechtich E, Shah K. IL13Ra2- and EGFR-targeted pseudomonas exotoxin potentiates the TRAIL-mediated death of GBM cells. Int J Mol Med. 2021 Jul; 48(1). PMID: 34080646.
    Citations:    Fields:    Translation:HumansCells
  11. van Schaik TA, Chen KS, Shah K. Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy? Front Oncol. 2021; 11:678562. PMID: 34141622; PMCID: PMC8204251.
    Citations: 4     
  12. Vaughan HJ, Zamboni CG, Radant NP, Bhardwaj P, Revai Lechtich E, Hassan LF, Shah K, Green JJ. Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer. Mol Ther Oncolytics. 2021 Jun 25; 21:377-388. PMID: 34189258; PMCID: PMC8208964.
    Citations: 3     
  13. Cingöz A, Ozyerli-Goknar E, Morova T, Seker-Polat F, Esai Selvan M, Gümüs ZH, Bhere D, Shah K, Solaroglu I, Bagci-Onder T. Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization. Oncogene. 2021 05; 40(18):3201-3216. PMID: 33767436.
    Citations: 2     Fields:    Translation:Humans
  14. López Vázquez M, Du W, Kanaya N, Kitamura Y, Shah K. Next-generation immunotherapies for brain metastatic cancers. Trends Cancer. 2021 09; 7(9):809-822. PMID: 33722479; PMCID: PMC8376747.
    Citations: 2     Fields:    Translation:Humans
  15. Song N, Wakimoto H, Rossignoli F, Bhere D, Ciccocioppo R, Chen KS, Khalsa JK, Mastrolia I, Samarelli AV, Dominici M, Shah K. Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID-19 related cytokine storm. Stem Cells. 2021 06; 39(6):707-722. PMID: 33586320; PMCID: PMC8014246.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
  16. Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, Bronisz A, Revai Lechtich E, Sasaki H, Mora JL, Brastianos PK, Falcone JL, Hofer AM, Franco A, Shah K. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021 03; 7(10). PMID: 33658202; PMCID: PMC7929513.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Khalsa JK, Shah K. Immune Profiling of Syngeneic Murine and Patient GBMs for Effective Translation of Immunotherapies. Cells. 2021 02 25; 10(3). PMID: 33668856; PMCID: PMC7996275.
    Citations: 2     Fields:    Translation:HumansAnimals
  18. Jiang L, Jung S, Zhao J, Kasinath V, Ichimura T, Joseph J, Fiorina P, Liss AS, Shah K, Annabi N, Joshi N, Akama TO, Bromberg JS, Kobayashi M, Uchimura K, Abdi R. Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery. Nano Today. 2021 Feb; 36. PMID: 33391389; PMCID: PMC7774643.
    Citations: 7     
  19. Kiyokawa J, Kawamura Y, Ghouse SM, Acar S, Barçin E, Martínez-Quintanilla J, Martuza RL, Alemany R, Rabkin SD, Shah K, Wakimoto H. Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma. Clin Cancer Res. 2021 02 01; 27(3):889-902. PMID: 33257429; PMCID: PMC7854507.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  20. Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R. Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. Cell. 2020 11 25; 183(5):1219-1233.e18. PMID: 33242418.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Akter F, Simon B, de Boer NL, Redjal N, Wakimoto H, Shah K. Pre-clinical tumor models of primary brain tumors: Challenges and opportunities. Biochim Biophys Acta Rev Cancer. 2021 01; 1875(1):188458. PMID: 33148506.
    Citations: 6     Fields:    Translation:HumansAnimals
  22. Khalsa JK, Cheng N, Keegan J, Chaudry A, Driver J, Bi WL, Lederer J, Shah K. Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types. Nat Commun. 2020 08 06; 11(1):3912. PMID: 32764562; PMCID: PMC7411074.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  23. Deng D, Shah K. TRAIL of Hope Meeting Resistance in Cancer. Trends Cancer. 2020 12; 6(12):989-1001. PMID: 32718904.
    Citations: 23     Fields:    Translation:HumansCells
  24. Yang EY, Shah K. Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics. Front Oncol. 2020; 10:1182. PMID: 32793488; PMCID: PMC7390931.
    Citations: 39     
  25. Levy O, Kuai R, Siren EMJ, Bhere D, Milton Y, Nissar N, De Biasio M, Heinelt M, Reeve B, Abdi R, Alturki M, Fallatah M, Almalik A, Alhasan AH, Shah K, Karp JM. Shattering barriers toward clinically meaningful MSC therapies. Sci Adv. 2020 07; 6(30):eaba6884. PMID: 32832666.
    Citations: 114     Fields:    Translation:HumansCellsPHPublic Health
  26. Song N, Scholtemeijer M, Shah K. Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential. Trends Pharmacol Sci. 2020 09; 41(9):653-664. PMID: 32709406.
    Citations: 86     Fields:    Translation:Cells
  27. Mineo M, Lyons SM, Zdioruk M, von Spreckelsen N, Ferrer-Luna R, Ito H, Alayo QA, Kharel P, Giantini Larsen A, Fan WY, Auduong S, Grauwet K, Passaro C, Khalsa JK, Shah K, Reardon DA, Ligon KL, Beroukhim R, Nakashima H, Ivanov P, Anderson PJ, Lawler SE, Chiocca EA. Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8. PMID: 32504554.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  28. Karakas N, Bay S, Türkel N, Öztunç N, Öncül M, Bilgen H, Shah K, Sahin F, Öztürk G. Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity. PLoS One. 2020; 15(5):e0228510. PMID: 32407317; PMCID: PMC7224507.
    Citations: 3     Fields:    Translation:HumansCells
  29. Lee YH, Pang SW, Revai Lechtich E, Shah K, Simon SE, Ponnusamy S, Narayanan R, Poh CL, Tan KO. Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1. J Cancer Res Clin Oncol. 2020 Jul; 146(7):1751-1764. PMID: 32377840.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  30. Bhere D, Arghiani N, Lechtich ER, Yao Y, Alsaab S, Bei F, Matin MM, Shah K. Simultaneous downregulation of miR-21 and upregulation of miR-7 has anti-tumor efficacy. Sci Rep. 2020 02 04; 10(1):1779. PMID: 32019988.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Kavari SL, Shah K. Engineered stem cells targeting multiple cell surface receptors in tumors. Stem Cells. 2020 01; 38(1):34-44. PMID: 31381835.
    Citations: 1     Fields:    Translation:HumansCells
  32. Martinez-Quintanilla J, Seah I, Chua M, Shah K. Oncolytic viruses: overcoming translational challenges. J Clin Invest. 2019 03 04; 129(4):1407-1418. PMID: 30829653; PMCID: PMC6436848.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  33. Tanaka S, Luk S, Kiyokawa J, Onozato ML, Iafrate AJ, Shah K, Martuza RL, Rabkin SD, Batchelor TT, Cahill DP, Chi AS, Wakimoto H. Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy. Sci Rep. 2019 01 15; 9(1):139. PMID: 30644426.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  34. Kuruppu D, Bhere D, Farrar CT, Shah K, Brownell AL, Tanabe KK. A model of breast cancer meningeal metastases: characterization with in vivo molecular imaging. Cancer Gene Ther. 2019 05; 26(5-6):145-156. PMID: 30420717.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  35. Passaro C, Alayo Q, De Laura I, McNulty J, Grauwet K, Ito H, Bhaskaran V, Mineo M, Lawler SE, Shah K, Speranza MC, Goins W, McLaughlin E, Fernandez S, Reardon DA, Freeman GJ, Chiocca EA, Nakashima H. Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 01 01; 25(1):290-299. PMID: 30279232; PMCID: PMC6800097.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  36. Reinshagen C, Bhere D, Choi SH, Hutten S, Nesterenko I, Wakimoto H, Le Roux E, Rizvi A, Du W, Minicucci C, Shah K. CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors. Sci Transl Med. 2018 07 11; 10(449). PMID: 29997250.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  37. Heidari P, Kunawudhi A, Martinez-Quintanilla J, Szretter A, Shah K, Mahmood U. Somatostatin receptor type 2 as a radiotheranostic PET reporter gene for oncologic interventions. Theranostics. 2018; 8(12):3380-3391. PMID: 29930736.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  38. Bhere D, Khajuria RK, Hendriks WT, Bandyopadhyay A, Bagci-Onder T, Shah K. Stem Cells Engineered During Different Stages of Reprogramming Reveal Varying Therapeutic Efficacies. Stem Cells. 2018 06; 36(6):932-942. PMID: 29451340.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  39. Bhere D, Tamura K, Wakimoto H, Choi SH, Purow B, Debatisse J, Shah K. microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis. Neuro Oncol. 2018 01 22; 20(2):215-224. PMID: 29016934; PMCID: PMC5777493.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  40. Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM. TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov. 2017 11; 7(11):1336-1353. PMID: 28974511.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  41. Choi SH, Stuckey DW, Pignatta S, Reinshagen C, Khalsa JK, Roozendaal N, Martinez-Quintanilla J, Tamura K, Keles E, Shah K. Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFNß in Glioblastomas. Clin Cancer Res. 2017 Nov 15; 23(22):7047-7058. PMID: 28912136; PMCID: PMC6818096.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  42. Jahan N, Lee JM, Shah K, Wakimoto H. Therapeutic targeting of chemoresistant and recurrent glioblastoma stem cells with a proapoptotic variant of oncolytic herpes simplex virus. Int J Cancer. 2017 10 15; 141(8):1671-1681. PMID: 28567859; PMCID: PMC5796532.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  43. Du W, Seah I, Bougazzoul O, Choi G, Meeth K, Bosenberg MW, Wakimoto H, Fisher D, Shah K. Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):E6157-E6165. PMID: 28710334; PMCID: PMC5544283.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  44. Ignatius MS, Hayes MN, Lobbardi R, Chen EY, McCarthy KM, Sreenivas P, Motala Z, Durbin AD, Molodtsov A, Reeder S, Jin A, Sindiri S, Beleyea BC, Bhere D, Alexander MS, Shah K, Keller C, Linardic CM, Nielsen PG, Malkin D, Khan J, Langenau DM. The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep. 2017 06 13; 19(11):2304-2318. PMID: 28614716.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  45. Zhu Y, Bassoff N, Reinshagen C, Bhere D, Nowicki MO, Lawler SE, Roux J, Shah K. Bi-specific molecule against EGFR and death receptors simultaneously targets proliferation and death pathways in tumors. Sci Rep. 2017 06 01; 7(1):2602. PMID: 28572590.
    Citations: 15     Fields:    Translation:HumansCells
  46. Choi SH, Shah K. Engineered bifunctional proteins and stem cells: next generation of targeted cancer therapeutics. Discov Med. 2016 09; 22(120):157-166. PMID: 27755970.
    Citations: 1     Fields:    Translation:HumansCells
  47. Shah K. Stem cell-based therapies for tumors in the brain: are we there yet? Neuro Oncol. 2016 08; 18(8):1066-78. PMID: 27282399; PMCID: PMC4933489.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  48. Zhu Y, Choi SH, Shah K. Multifunctional receptor-targeting antibodies for cancer therapy. Lancet Oncol. 2015 Nov; 16(15):e543-e554. PMID: 26545843.
    Citations: 14     Fields:    Translation:Humans
  49. Wehrenberg-Klee E, Redjal N, Leece A, Turker NS, Heidari P, Shah K, Mahmood U. PET imaging of glioblastoma multiforme EGFR expression for therapeutic decision guidance. Am J Nucl Med Mol Imaging. 2015; 5(4):379-89. PMID: 26269775; PMCID: PMC4529591.
    Citations: 8     
  50. Bhere D, Shah K. Stem Cell-Based Therapies for Cancer. Adv Cancer Res. 2015; 127:159-89. PMID: 26093900.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  51. Bagci-Onder T, Du W, Figueiredo JL, Martinez-Quintanilla J, Shah K. Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells. Brain. 2015 Jun; 138(Pt 6):1710-21. PMID: 25910782; PMCID: PMC4542623.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  52. Stuckey DW, Hingtgen SD, Karakas N, Rich BE, Shah K. Engineering toxin-resistant therapeutic stem cells to treat brain tumors. Stem Cells. 2015 Feb; 33(2):589-600. PMID: 25346520.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  53. Redjal N, Zhu Y, Shah K. Combination of systemic chemotherapy with local stem cell delivered S-TRAIL in resected brain tumors. Stem Cells. 2015 Jan; 33(1):101-10. PMID: 25186100.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  54. Martinez-Quintanilla J, Shah K. Response. J Natl Cancer Inst. 2015 Jan; 107(1):370. PMID: 25473105.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  55. Choi SH, Tamura K, Khajuria RK, Bhere D, Nesterenko I, Lawler J, Shah K. Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas. Mol Ther. 2015 Feb; 23(2):235-43. PMID: 25358253; PMCID: PMC4445617.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  56. Martinez-Quintanilla J, He D, Wakimoto H, Alemany R, Shah K. Encapsulated stem cells loaded with hyaluronidase-expressing oncolytic virus for brain tumor therapy. Mol Ther. 2015 Jan; 23(1):108-18. PMID: 25352242.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  57. Stuckey DW, Shah K. Stem cell-based therapies for cancer treatment: separating hope from hype. Nat Rev Cancer. 2014 10; 14(10):683-91. PMID: 25176333.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  58. Sullivan JP, Nahed BV, Madden MW, Oliveira SM, Springer S, Bhere D, Chi AS, Wakimoto H, Rothenberg SM, Sequist LV, Kapur R, Shah K, Iafrate AJ, Curry WT, Loeffler JS, Batchelor TT, Louis DN, Toner M, Maheswaran S, Haber DA. Brain tumor cells in circulation are enriched for mesenchymal gene expression. Cancer Discov. 2014 Nov; 4(11):1299-309. PMID: 25139148; PMCID: PMC4221467.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  59. Srivastava J, Robertson CL, Rajasekaran D, Gredler R, Siddiq A, Emdad L, Mukhopadhyay ND, Ghosh S, Hylemon PB, Gil G, Shah K, Bhere D, Subler MA, Windle JJ, Fisher PB, Sarkar D. AEG-1 regulates retinoid X receptor and inhibits retinoid signaling. Cancer Res. 2014 Aug 15; 74(16):4364-77. PMID: 25125681.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  60. Kuruppu D, Brownell AL, Shah K, Mahmood U, Tanabe KK. Molecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability. Cancer Res. 2014 Aug 01; 74(15):4111-21. PMID: 24876106.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  61. Duebgen M, Martinez-Quintanilla J, Tamura K, Hingtgen S, Redjal N, Wakimoto H, Shah K. Stem cells loaded with multimechanistic oncolytic herpes simplex virus variants for brain tumor therapy. J Natl Cancer Inst. 2014 Jun; 106(6):dju090. PMID: 24838834.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  62. Du W, Uslar L, Sevala S, Shah K. Targeting c-Met receptor overcomes TRAIL-resistance in brain tumors. PLoS One. 2014; 9(4):e95490. PMID: 24748276.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  63. Zhu Y, Shah K. Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384. Cancer Biol Ther. 2014 Jun 01; 15(6):815-22. PMID: 24658109; PMCID: PMC4049797.
    Citations: 22     Fields:    Translation:HumansCells
  64. Stuckey DW, Shah K. TRAIL on trial: preclinical advances in cancer therapy. Trends Mol Med. 2013 Nov; 19(11):685-94. PMID: 24076237.
    Citations: 111     Fields:    Translation:HumansAnimals
  65. Martinez-Quintanilla J, Bhere D, Heidari P, He D, Mahmood U, Shah K. Therapeutic efficacy and fate of bimodal engineered stem cells in malignant brain tumors. Stem Cells. 2013 Aug; 31(8):1706-14. PMID: 23389839.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  66. Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L. High efficiency diffusion molecular retention tumor targeting. PLoS One. 2013; 8(3):e58290. PMID: 23505478.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  67. Shah K. Encapsulated stem cells for cancer therapy. Biomatter. 2013 Jan-Mar; 3(1). PMID: 23507920.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  68. Hingtgen S, Figueiredo JL, Farrar C, Duebgen M, Martinez-Quintanilla J, Bhere D, Shah K. Real-time multi-modality imaging of glioblastoma tumor resection and recurrence. J Neurooncol. 2013 Jan; 111(2):153-61. PMID: 23242736.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  69. Nesterenko I, Wanningen S, Bagci-Onder T, Anderegg M, Shah K. Evaluating the effect of therapeutic stem cells on TRAIL resistant and sensitive medulloblastomas. PLoS One. 2012; 7(11):e49219. PMID: 23145127.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  70. Srivastava J, Siddiq A, Emdad L, Santhekadur PK, Chen D, Gredler R, Shen XN, Robertson CL, Dumur CI, Hylemon PB, Mukhopadhyay ND, Bhere D, Shah K, Ahmad R, Giashuddin S, Stafflinger J, Subler MA, Windle JJ, Fisher PB, Sarkar D. Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology. 2012 Nov; 56(5):1782-91. PMID: 22689379; PMCID: PMC3449036.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  71. van de Water JA, Bagci-Onder T, Agarwal AS, Wakimoto H, Roovers RC, Zhu Y, Kasmieh R, Bhere D, Van Bergen en Henegouwen PM, Shah K. Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16642-7. PMID: 23012408.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  72. Tamura K, Wakimoto H, Agarwal AS, Rabkin SD, Bhere D, Martuza RL, Kuroda T, Kasmieh R, Shah K. Multimechanistic tumor targeted oncolytic virus overcomes resistance in brain tumors. Mol Ther. 2013 Jan; 21(1):68-77. PMID: 22929661.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  73. Hingtgen S, Kasmieh R, Elbayly E, Nesterenko I, Figueiredo JL, Dash R, Sarkar D, Hall D, Kozakov D, Vajda S, Fisher PB, Shah K. A first-generation multi-functional cytokine for simultaneous optical tracking and tumor therapy. PLoS One. 2012; 7(7):e40234. PMID: 22808125.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  74. Kauer TM, Figueiredo JL, Hingtgen S, Shah K. Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas. Nat Neurosci. 2011 Dec 25; 15(2):197-204. PMID: 22197831.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  75. Shah K. Mesenchymal stem cells engineered for cancer therapy. Adv Drug Deliv Rev. 2012 Jun 01; 64(8):739-48. PMID: 21740940.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  76. Shah K. Imaging fate of stem cells at a cellular resolution in the brains of mice. Methods Mol Biol. 2011; 680:91-101. PMID: 21153375.
    Citations:    Fields:    Translation:HumansAnimalsCells
  77. Shah K. In vivo imaging of the dynamics of different variants of EGFR in glioblastomas. Methods Mol Biol. 2011; 680:153-64. PMID: 21153380.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  78. Bagci-Onder T, Wakimoto H, Anderegg M, Cameron C, Shah K. A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell-delivered TRAIL in experimental glioma models. Cancer Res. 2011 Jan 01; 71(1):154-63. PMID: 21084267.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  79. Yoo BK, Chen D, Su ZZ, Gredler R, Yoo J, Shah K, Fisher PB, Sarkar D. Molecular mechanism of chemoresistance by astrocyte elevated gene-1. Cancer Res. 2010 Apr 15; 70(8):3249-58. PMID: 20388796.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  80. Hingtgen SD, Kasmieh R, van de Water J, Weissleder R, Shah K. A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy. Stem Cells. 2010 Apr; 28(4):832-41. PMID: 20127797.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  81. van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K. Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors. Oncogene. 2010 Jun 03; 29(22):3185-95. PMID: 20305695.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  82. Hamed HA, Yacoub A, Park MA, Eulitt PJ, Dash R, Sarkar D, Dmitriev IP, Lesniak MS, Shah K, Grant S, Curiel DT, Fisher PB, Dent P. Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma. Mol Ther. 2010 Jun; 18(6):1130-42. PMID: 20179672.
    Citations: 27     Fields:    Translation:HumansCells
  83. Emdad L, Sarkar D, Lee SG, Su ZZ, Yoo BK, Dash R, Yacoub A, Fuller CE, Shah K, Dent P, Bruce JN, Fisher PB. Astrocyte elevated gene-1: a novel target for human glioma therapy. Mol Cancer Ther. 2010 Jan; 9(1):79-88. PMID: 20053777.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  84. Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D. Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12938-43. PMID: 19622726.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  85. Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA. Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Opt Lett. 2009 Jul 01; 34(13):2066-8. PMID: 19572001.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  86. Wakimoto H, Kesari S, Farrell CJ, Curry WT, Zaupa C, Aghi M, Kuroda T, Stemmer-Rachamimov A, Shah K, Liu TC, Jeyaretna DS, Debasitis J, Pruszak J, Martuza RL, Rabkin SD. Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors. Cancer Res. 2009 Apr 15; 69(8):3472-81. PMID: 19351838.
    Citations: 203     Fields:    Translation:HumansAnimalsCells
  87. Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, Figueiredo JL, Martuza RL, Weissleder R, Shah K. Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4822-7. PMID: 19264968.
    Citations: 206     Fields:    Translation:HumansAnimalsCells
  88. Shah K. Imaging neural stem cell fate in mouse model of glioma. Curr Protoc Stem Cell Biol. 2009 Mar; Chapter 5:Unit 5A.1. PMID: 19306259.
    Citations: 6     Fields:    Translation:AnimalsCells
  89. Hingtgen S, Ren X, Terwilliger E, Classon M, Weissleder R, Shah K. Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide. Mol Cancer Ther. 2008 Nov; 7(11):3575-85. PMID: 19001440.
    Citations: 46     Fields:    Translation:HumansCells
  90. Dent P, Yacoub A, Park M, Sarkar D, Shah K, Curiel DT, Grant S, Fisher PB. Searching for a cure: gene therapy for glioblastoma. Cancer Biol Ther. 2008 Sep; 7(9):1335-40. PMID: 18708757.
    Citations: 11     Fields:    Translation:Cells
  91. Yip S, Shah K. Stem-cell based therapies for brain tumors. Curr Opin Mol Ther. 2008 Aug; 10(4):334-42. PMID: 18683097.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  92. Deliolanis NC, Kasmieh R, Wurdinger T, Tannous BA, Shah K, Ntziachristos V. Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications. J Biomed Opt. 2008 Jul-Aug; 13(4):044008. PMID: 19021336.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  93. Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R. Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model. J Neurosci. 2008 Apr 23; 28(17):4406-13. PMID: 18434519.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  94. Corsten MF, Shah K. Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfare. Lancet Oncol. 2008 Apr; 9(4):376-84. PMID: 18374291.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  95. Yacoub A, Hamed H, Emdad L, Dos Santos W, Gupta P, Broaddus WC, Ramakrishnan V, Sarkar D, Shah K, Curiel DT, Grant S, Fisher PB, Dent P. MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors. Cancer Biol Ther. 2008 Jun; 7(6):917-33. PMID: 18376144.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  96. Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res. 2007 Oct 01; 67(19):8994-9000. PMID: 17908999.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  97. Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K. Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo. Cancer Res. 2007 Aug 01; 67(15):7335-42. PMID: 17671203.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  98. Kock N, Kasmieh R, Weissleder R, Shah K. Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL. Neoplasia. 2007 May; 9(5):435-42. PMID: 17534449.
    Citations: 39     Fields:    Translation:AnimalsCells
  99. Ismail S, Khan FA, Ahmed A, Shah KA. Premedication in surgical day care patients. J Pak Med Assoc. 2007 Jan; 57(1):37-8. PMID: 17319419.
    Citations:    Fields:    Translation:Humans
  100. Shah K, Breakefield XO. HSV amplicon vectors for cancer therapy. Curr Gene Ther. 2006 Jun; 6(3):361-70. PMID: 16787187.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  101. Shah K, Tung CH, Breakefield XO, Weissleder R. In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis. Mol Ther. 2005 Jun; 11(6):926-31. PMID: 15922963.
    Citations: 35     Fields:    Translation:HumansAnimals
  102. Shah K. Current advances in molecular imaging of gene and cell therapy for cancer. Cancer Biol Ther. 2005 May; 4(5):518-23. PMID: 15908803.
    Citations: 7     Fields:    Translation:HumansAnimals
  103. Shah K, Weissleder R. Molecular optical imaging: applications leading to the development of present day therapeutics. NeuroRx. 2005 Apr; 2(2):215-25. PMID: 15897946.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  104. Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO. Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol. 2005 Jan; 57(1):34-41. PMID: 15622535.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  105. Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO. Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy. Cancer Res. 2004 May 01; 64(9):3236-42. PMID: 15126365.
    Citations: 38     Fields:    Translation:AnimalsCells
  106. Shah K, Hsich G, Breakefield XO. Neural precursor cells and their role in neuro-oncology. Dev Neurosci. 2004 Mar-Aug; 26(2-4):118-30. PMID: 15711055.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  107. Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R. In vivo imaging of beta-galactosidase activity using far red fluorescent switch. Cancer Res. 2004 Mar 01; 64(5):1579-83. PMID: 14996712.
    Citations: 51     Fields:    Translation:AnimalsCells
  108. Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, Weissleder R, Breakefield XO, Tung CH. A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe. Neoplasia. 2004 Mar-Apr; 6(2):95-105. PMID: 15140398.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  109. Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R. Imaging of stem cell recruitment to ischemic infarcts in a murine model. Stroke. 2004 Apr; 35(4):952-7. PMID: 14988578.
    Citations: 42     Fields:    Translation:AnimalsCells
  110. Ahmed A, Shah KA. Peri-operative management of a patient with uncontrolled Polycythemia Vera for above knee amputation. J Pak Med Assoc. 2004 Jan; 54(1):34-6. PMID: 15058642.
    Citations:    Fields:    Translation:Humans
  111. Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R. In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas. Cancer Res. 2004 Jan 01; 64(1):273-8. PMID: 14729634.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  112. Shah K, Tang Y, Breakefield X, Weissleder R. Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo. Oncogene. 2003 Oct 09; 22(44):6865-72. PMID: 14534533.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  113. Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R. In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther. 2003 Sep 01; 14(13):1247-54. PMID: 12952596.
    Citations: 87     Fields:    Translation:AnimalsCells
  114. Shah K, Vervoort J, de Vries SC. Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation. J Biol Chem. 2001 Nov 02; 276(44):41263-9. PMID: 11509554.
    Citations: 47     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.