Harvard Catalyst Profiles

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Ilknur Ay, M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS120594 (BONMASSAR, GIORGIO) Jun 1, 2021 - May 31, 2024
    Simultaneous functional MRI and Micro-Magnetic Nervous System Stimulation
    Role: Co-Principal Investigator
  2. R01DK109349 (AY, ILKNUR) Apr 1, 2017 - Mar 31, 2021
    Renal hypoxia in the development of glomerular fibrosis
    Role: Principal Investigator
  3. R21NS081395 (AY, ILKNUR) Sep 30, 2012 - Dec 31, 2014
    Transcutaneous vagus nerve stimulation in cerebral ischemia
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Arsava EM, Topcuoglu MA, Ay I, Ozdemir AO, Gungor IL, Togay Isikay C, Nazliel B, Kozak HH, Ozturk S, Yilmaz IA, Dora B, Ay H. Assessment of safety and feasibility of non-invasive vagus nerve stimulation for treatment of acute stroke. Brain Stimul. 2022 Nov-Dec; 15(6):1467-1474. PMID: 36356829.
    Citations:    Fields:    Translation:Humans
  2. Jeong H, Cho A, Ay I, Bonmassar G. Short-pulsed micro-magnetic stimulation of the vagus nerve. Front Physiol. 2022; 13:938101. PMID: 36277182; PMCID: PMC9585240.
  3. Izquierdo-Garcia D, Diyabalanage H, Ramsay IA, Rotile NJ, Mauskapf A, Choi JK, Witzel T, Humblet V, Jaffer FA, Brownell AL, Tawakol A, Catana C, Conrad MF, Caravan P, Ay I. Imaging High-Risk Atherothrombosis Using a Novel Fibrin-Binding Positron Emission Tomography Probe. Stroke. 2022 02; 53(2):595-604. PMID: 34965737; PMCID: PMC8792326.
    Citations:    Fields:    Translation:HumansAnimals
  4. Zhou IY, Ramsay IA, Ay I, Pantazopoulos P, Rotile NJ, Wong A, Caravan P, Gale EM. Positron Emission Tomography-Magnetic Resonance Imaging Pharmacokinetics, In Vivo Biodistribution, and Whole-Body Elimination of Mn-PyC3A. Invest Radiol. 2021 04 01; 56(4):261-270. PMID: 33136686; PMCID: PMC7933117.
    Citations:    Fields:    Translation:Animals
  5. Morais A, Liu TT, Qin T, Sadhegian H, Ay I, Yagmur D, Mendes da Silva R, Chung D, Simon B, Guedes R, Chen SP, Wang SJ, Yen JC, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression exclusively through central mechanisms. Pain. 2020 07; 161(7):1661-1669. PMID: 32142015; PMCID: PMC7305968.
    Citations: 10     Fields:    Translation:Animals
  6. Sclocco R, Garcia RG, Kettner NW, Isenburg K, Fisher HP, Hubbard CS, Ay I, Polimeni JR, Goldstein J, Makris N, Toschi N, Barbieri R, Napadow V. The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field (7T) fMRI study. Brain Stimul. 2019 Jul - Aug; 12(4):911-921. PMID: 30803865.
    Citations: 22     Fields:    Translation:HumansAnimals
  7. Park KY, Ay I, Avery R, Caceres JA, Siket MS, Pontes-Neto OM, Zheng H, Rost NS, Furie KL, Sorensen AG, Koroshetz WJ, Ay H. New biomarker for acute ischaemic stroke: plasma glycogen phosphorylase isoenzyme BB. J Neurol Neurosurg Psychiatry. 2018 04; 89(4):404-409. PMID: 29030420.
    Citations: 7     Fields:    Translation:Humans
  8. Chen SP, Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain. 2016 Apr; 157(4):797-805. PMID: 26645547; PMCID: PMC4943574.
    Citations: 41     Fields:    Translation:Animals
  9. Gale EM, Atanasova IP, Blasi F, Ay I, Caravan P. A Manganese Alternative to Gadolinium for MRI Contrast. J Am Chem Soc. 2015 Dec 16; 137(49):15548-57. PMID: 26588204; PMCID: PMC4764508.
    Citations: 55     Fields:    Translation:Cells
  10. Ay I, Nasser R, Simon B, Ay H. Transcutaneous Cervical Vagus Nerve Stimulation Ameliorates Acute Ischemic Injury in Rats. Brain Stimul. 2016 Mar-Apr; 9(2):166-73. PMID: 26723020.
    Citations: 29     Fields:    Translation:Animals
  11. Ay I, Napadow V, Ay H. Electrical stimulation of the vagus nerve dermatome in the external ear is protective in rat cerebral ischemia. Brain Stimul. 2015 Jan-Feb; 8(1):7-12. PMID: 25312600.
    Citations: 26     Fields:    Translation:Animals
  12. Blasi F, Oliveira BL, Rietz TA, Rotile NJ, Day H, Looby RJ, Ay I, Caravan P. Effect of Chelate Type and Radioisotope on the Imaging Efficacy of 4 Fibrin-Specific PET Probes. J Nucl Med. 2014 Jul; 55(7):1157-63. PMID: 24790217.
    Citations: 13     Fields:    Translation:Animals
  13. Ay I, Blasi F, Rietz TA, Rotile NJ, Kura S, Brownell AL, Day H, Oliveira BL, Looby RJ, Caravan P. In vivo molecular imaging of thrombosis and thrombolysis using a fibrin-binding positron emission tomographic probe. Circ Cardiovasc Imaging. 2014 Jul; 7(4):697-705. PMID: 24777937.
    Citations: 20     Fields:    Translation:Animals
  14. Ciesienski KL, Yang Y, Ay I, Chonde DB, Loving GS, Rietz TA, Catana C, Caravan P. Fibrin-targeted PET probes for the detection of thrombi. Mol Pharm. 2013 Mar 04; 10(3):1100-10. PMID: 23327109.
    Citations: 29     Fields:    Translation:Animals
  15. Ay I, Ay H. Ablation of the sphenopalatine ganglion does not attenuate the infarct reducing effect of vagus nerve stimulation. Auton Neurosci. 2013 Mar; 174(1-2):31-5. PMID: 23273773.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Ay I, Sorensen AG, Ay H. Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: an unlikely role for cerebral blood flow. Brain Res. 2011 May 25; 1392:110-5. PMID: 21458427.
    Citations: 39     Fields:    Translation:Animals
  17. Uppal R, Catana C, Ay I, Benner T, Sorensen AG, Caravan P. Bimodal thrombus imaging: simultaneous PET/MR imaging with a fibrin-targeted dual PET/MR probe--feasibility study in rat model. Radiology. 2011 Mar; 258(3):812-20. PMID: 21177389; PMCID: PMC3042637.
    Citations: 37     Fields:    Translation:Animals
  18. Uppal R, Ay I, Dai G, Kim YR, Sorensen AG, Caravan P. Molecular MRI of intracranial thrombus in a rat ischemic stroke model. Stroke. 2010 Jun; 41(6):1271-7. PMID: 20395615.
    Citations: 29     Fields:    Translation:Animals
  19. Li J, Chian RJ, Ay I, Kashi BB, Celia SA, Tamrazian E, Pepinsky RB, Fishman PS, Brown RH, Francis JW. Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS. Biochem Biophys Res Commun. 2009 Dec 18; 390(3):947-51. PMID: 19852934.
    Citations: 8     Fields:    Translation:AnimalsCells
  20. Chian RJ, Li J, Ay I, Celia SA, Kashi BB, Tamrazian E, Matthews JC, Bronson RT, Rossomando A, Pepinsky RB, Fishman PS, Brown RH, Francis JW. IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice. Brain Res. 2009 Sep 01; 1287:1-19. PMID: 19563785.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  21. Li J, Chian RJ, Ay I, Celia SA, Kashi BB, Tamrazian E, Matthews JC, Remington MP, Pepinsky RB, Fishman PS, Brown RH, Francis JW. Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells. Biochem Biophys Res Commun. 2009 Jul 31; 385(3):380-4. PMID: 19465006.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Ay I, Lu J, Ay H, Gregory Sorensen A. Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia. Neurosci Lett. 2009 Aug 14; 459(3):147-51. PMID: 19446004.
    Citations: 37     Fields:    Translation:Animals
  23. Ay I, Francis JW, Brown RH. VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice. Brain Res. 2008 Oct 09; 1234:198-205. PMID: 18725212.
    Citations: 23     Fields:    Translation:AnimalsCells
  24. Larsen KE, Benn SC, Ay I, Chian RJ, Celia SA, Remington MP, Bejarano M, Liu M, Ross J, Carmillo P, Sah D, Phillips KA, Sulzer D, Pepinsky RB, Fishman PS, Brown RH, Francis JW. A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice. Brain Res. 2006 Nov 20; 1120(1):1-12. PMID: 17020749.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  25. Ay I, Tuncer M. Both endothelium and afferent nerve endings play a role in acetylcholine-induced renal vasodilation. Life Sci. 2006 Jul 24; 79(9):877-82. PMID: 16616212.
    Citations: 1     Fields:    Translation:AnimalsCells
  26. Benn SC, Ay I, Bastia E, Chian RJ, Celia SA, Pepinsky RB, Fishman PS, Brown RH, Francis JW. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. J Neurochem. 2005 Nov; 95(4):1118-31. PMID: 16271047.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  27. Broom WJ, Ay I, Pasinelli P, Brown RH. Inhibition of SOD1 expression by mitomycin C is a non-specific consequence of cellular toxicity. Neurosci Lett. 2006 Jan 30; 393(2-3):184-8. PMID: 16242241.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  28. Kabakus N, Ay I, Aysun S, Söylemezoglu F, Ozcan A, Celasun B. Protective effects of valproic acid against hypoxic-ischemic brain injury in neonatal rats. J Child Neurol. 2005 Jul; 20(7):582-7. PMID: 16159524.
    Citations: 15     Fields:    Translation:Animals
  29. Ay I, Tuncer M. Mechanism of CGRP-induced vasodilation in the rat isolated perfused kidney. Pharmacology. 2004 Aug; 71(4):209-15. PMID: 15240997.
    Citations: 1     Fields:    Translation:Animals
  30. Ay I, Sugimori H, Finklestein SP. Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):71-80. PMID: 11223161.
    Citations: 19     Fields:    Translation:AnimalsCells
  31. Ay I, Emre S, Tuncer M. Factors responsible for acetylcholine-induced dilatation in the isolated perfused rat kidney. Gen Pharmacol. 2000 Mar; 34(3):175-81. PMID: 11120379.
    Citations:    Fields:    Translation:Animals
  32. Emre S, Ay I, Tuncer M. The relaxation induced by nicotine in the rat isolated renal artery. Gen Pharmacol. 1999 Jul; 33(1):23-7. PMID: 10428012.
    Citations: 1     Fields:    Translation:Animals
  33. Ay H, Ay I, Koroshetz WJ, Finklestein SP. Potential usefulness of basic fibroblast growth factor as a treatment for stroke. Cerebrovasc Dis. 1999 May-Jun; 9(3):131-5. PMID: 10207203.
    Citations: 17     Fields:    Translation:AnimalsCells
  34. Ay I, Tuncer M. Vasodilatation induced by nicotine in the isolated perfused rat kidney. Gen Pharmacol. 1998 May; 30(5):651-4. PMID: 9559314.
    Citations: 1     Fields:    Translation:Animals
  35. Yildiz O, Ciçek S, Ay I, Demirkiliç U, Tuncer M. Hypertension increases the contractions to sumatriptan in the human internal mammary artery. Ann Thorac Surg. 1996 Nov; 62(5):1392-5; discussion 1396. PMID: 8893574.
    Citations: 4     Fields:    Translation:Humans
  36. Yildiz O, Ciçek S, Ay I, Tatar H, Tuncer M. 5-HT1-like receptor-mediated contraction in the human internal mammary artery. J Cardiovasc Pharmacol. 1996 Jul; 28(1):6-10. PMID: 8797129.
    Citations: 4     Fields:    Translation:Humans
  37. Ay I, Tuncer M, Onur R. Effects of Androctonus crassicauda scorpion venom on endothelium-dependent and -independent vascular responses of rabbit aorta. Gen Pharmacol. 1996 Apr; 27(3):519-23. PMID: 8723537.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.